<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L10I
Rx >= 1 PI
IncludeMixtures No
References 19
Patients 41
Isolates 50
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Kantor (2002)TCDD-30TCDD-30_1AY090856NFV, IDV14  L10I, T12A, I15V, L19I, E35D, M36I, N37ND, R41K, H69KQ, L89M, I93ILC
Johnston (2003)TC-71TC-71 IDV52G48V, I54T, V82A L10I, I15V, L19I, K20R, E35D, M36I, R41K, L63V, H69K, A71V, T74S, L89M, I93LC
Weber (2003)85H610185H-12AY140821RTV13  L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69K, T74S, V77I, L89M, I93LC
  610185H-48AY140823RTV48I54V, V82A L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63V, H69R, T74S, V77I, L89M, I93LC
Grossman (2004)IL201IL201aAY529564IDV16  L10I, T12S, I15V, L19T, M36I, R41K, L63P, I64L, H69K, K70KE, L89M, I93LC
  IL201bAY529565IDV55  W6S, L10I, T12S, I15V, L19T, M36I, R41K, L63X, I64IL, H69KC
  IL201cAY529566IDV83  L10I, T12S, I15V, L19T, M36I, L63P, I64L, H69K, L89T, I93LC
 IL217IL217AY529576NFV104D30NN88DL10I, I13V, K14R, I15V, K20R, E35D, M36I, R41K, L63Q, I64IV, H69Q, L89IM, I93LC
 IL266IL266AY529621SQV, RTV, IDV, NFV180I54IL, I84V, L90MT74TPR8RG, L10I, I15V, K20KI, E35EG, M36I, R41RK, L63P, H69K, A71V, L89M, Q92QR, I93LC
 IL287IL287AY529620SQV, RTV, IDV, NFV184I84V, L90M L5LI, L10I, T12S, I15V, L19I, E35D, M36I, R41K, L63T, H69K, A71V, T74S, I93LC
Montes (2004)MB_patCOU02_COUL707AJ577870SQV, RTV, IDV, NFV221L90MG73SL10I, T12S, I15V, K20T, M36I, R41K, L63P, H69K, A71V, I93LC
Snoeck (2004)BE59BE59AY900757SQV, IDV, RTV, NFV217G48V, I54A, V82AL33F, K43KTL10I, I13V, I15V, L19I, M36L, N37EQ, L38M, I62V, L63V, H69K, I72V, T74S, L89LI, I93LC
Non-B Workgroup (2005)UK186bUK186bAY900763SQV, RTV183I84V, L90MV11VI, G73GSL10I, I15V, G16E, L19I, R41K, L63H, H69K, A71V, V77I, I93LC
 UK955UK955AY900786SQV, RTV, IDV137I54V, I84V, L90MG73S, L89VL10I, I15V, L19I, K20X, E35D, M36I, R41K, D60E, I62IV, L63P, H69K, A71V, I85V, I93LC
 IL257IL257AY900818IDV, RTV110V82A L10I, I15V, L19I, D29DV, M36I, R41K, L63P, H69K, I85V, I93LC
 TK1020TK1020 SQV, RTV, IDV211I54V, V82C, L90MF53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, K55H, L63P, H69K, T74A, L89M, I93LC
  TK1020a SQV, RTV, IDV, LPV229M46L, I54V, V82C, L90ML23I, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, K55H, L63P, H69K, T74A, L89M, I93LC
  TK1020b SQV, RTV, IDV, LPV392M46I, I47V, I54V, V82C, L90ML23I, K43T, F53LL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41RK, K55H, I62V, L63P, H69K, T74E, L89M, I93LC
 TK2023TK2023 RTV, IDV, SQV173  L10I, I15V, L19I, M36I, R41K, L63V, H69K, T74S, V75I, L89M, I93LC
 TK3015TK3015 SQV, IDV204I54V, V82A, L90MK43TL10I, T12S, I15V, L19I, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015c SQV, IDV, LPV, RTV, TPV375I54V, V82T, I84IV, L90MK43TL10I, T12S, I15V, L19I, K20IR, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, L89LM, I93LC
 TK3019TK3019 SQV, NFV, RTV143I54V, I84IV, L90MV11VI, G73SL10I, I13V, I15V, L19I, K20R, E35D, M36I, R41K, K45R, I62V, L63P, H69T, A71V, I72L, I93LC
 TK3035TK3035 IDV, NFV, RTV202I54A, V82A L10I, T12S, I15V, L19I, K20R, E35D, M36I, R41K, K45KR, D60E, L63P, H69K, A71V, L89M, I93LC
 TK5007TK5007 IDV, RTV261 G73STL10I, T12S, I15V, L19I, E35D, M36I, N37S, R41K, K45R, I62V, L63P, H69K, I85V, I93LC
 PL3670560970 IDV98V82A, L90LMT74PL10I, T12TS, I15V, L19I, K20KR, M36I, N37NS, R41K, K45R, Q61N, L63S, H69K, I72V, L89M, I93LC
 PL472558294 Unknown, LPV>4G48V, I54V, V82T, L90MQ58EL10I, I15V, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71T, T74S, I85V, L89I, I93LC
 PL833877353 IDV, RTV304I54V, V82A L10I, I13IV, I15V, L19I, M36L, R41K, I62V, L63P, I64V, H69K, L89M, I93L, C95FC
Weber (2005)F16446F16446AY677447SQV, NFV, APV, LPV208M46I, I54V, I84V, L90M L10I, T12S, L19I, K20M, M36I, R41K, D60E, L63P, H69K, L89M, I93LC
 F30356F30356AY677479Unknown, NFV>201I54V, V82A, L90M L10I, T12S, I15V, L19T, K20R, E35D, M36I, N37H, P39PS, R41K, K45R, L63P, H69KQ, A71I, I93LC
Baxter (2006)12-10071007-30519DQ875953PINAM46L, I54IV, V82A, L90ML33F, K43KTL10I, I15V, L19T, K20R, E35D, M36I, R41K, Q61E, I62IV, L63P, H69K, T74S, L89M, I93LC
 12-17161716-30421DQ876854PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10I, I15V, K20R, E35D, M36I, N37ND, R41K, I62V, L63T, H69K, T74S, L89M, I93LC
 12-30823082-30430DQ877155PINAM46I, I84V, L90MG73SL10I, T12S, I13N, I15V, L19I, M36I, R41RK, Q61H, L63P, H69K, A71V, I72L, I93LC
 12-31023102-30610DQ877250PINAL90ML23I, L33F, F53L, Q58EL10I, T12P, I15V, G16E, L19V, K20R, E35D, M36I, N37T, I62V, L63T, H69K, T74A, V82I, I85V, L89M, I93LC
 48-12291229-30428DQ877762PINAM46I, I54A, V82F, L90M L10I, T12S, I13V, Q18R, L19I, K20I, E34EQ, E35E_PSDGNS, M36L, I62V, L63P, H69K, T74A, V77I, L89M, I93LC
 48-30583058-30401DQ877970PINAI54L, V82A, L90ML33F, K43KTL10I, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63P, H69K, T74S, L89M, I93LC
 48-41344134-30317DQ878365PINAG48V, I54V, V82A, I84VL33F, K43TL10I, I15V, G16E, L19I, K20V, E35DN, M36I, L63C, H69K, T74S, I85V, L89M, I93LC
 48-80568056-30930DQ879080PINAV32I, I47AL33F, Q58EL10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93LC
Sanabani (2006)04BR01304BR013AY727522PINAM46I, G48V, V82AL24IL10I, K20R, M36I, N37E, R41K, K55R, I62V, L63P, H69K, T74A, L89M, I93LC
McGrath (2007)7DMG_7a ATV48  L10I, I13V, G16GE, L19T, K20R, M36I, R41K, L63AITV, I64IM, E65D, H69K, T74TA, L89M, I93LC
Sen (2007)T076NPT76-PLEF186980NFV, RTV M46LT74PL10I, T12S, L19I, K20R, M36I, K55N, L63P, H69K, A71V, L89M, I93LC
 T002NPT2EF186926RTV, IDV M46I, I54V, V82VAL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, L89M, I93LC
  NPT2-PLEF186983RTV, IDV M46I, I54V, V82AL24IL10I, T12S, I15V, L19I, M36L, N37S, R41K, Q61H, L63P, H69K, A71AV, L89M, I93LC
Pillay (2008)DR44DR44AY589899RTV M46I, I54V, V82A L10I, I15V, L19I, K20R, M36I, N37S, H69K, L89M, I93LC
Kandathil (2009)VL07_103VL07_103EU781835PINAM46I, I54V, V82AL24IL10I, T12S, I15V, L19T, M36I, R41K, L63P, H69K, L89M, I93LC
Kassaye (2009)TCDD-30TC30_2003FJ445708NFV, IDV99I54V, I84V L10I, T12A, I15V, L19I, K20KR, E35D, M36I, R41K, L63P, H69Q, L89M, I93LC
Dau (2010)06552A06552AGU581760PINAM46I, I54V, L76V, V82A L10I, I13V, G16GE, L19I, K20R, M36I, N37ND, R41K, Q61N, L63PS, H69K, T74S, L89M, I93LC
Knops (2010)ID2137ID2137-GT1GU271172IDV, LPV V32I, I47A, V82A L10I, T12S, I15V, L19AP, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93LC
  ID2137-GT2GU271173IDV, LPV, DRV, RTV33V32I, I54L, L76V, V82AL89VL5F, L10I, T12S, I15V, L19T, K20R, M36I, R41K, L63P, H69K, A71V, I85V, I93LC
Green (2011)707PKE19F707PKE19FHM623509RTV, LPV131M46I, I54V, L76V, V82AQ58EL10I, T12S, I15V, L19T, K20R, E35D, M36I, R41K, I62V, L63P, H69K, L89M, I93LC
Barber (2012)6599465994JQ361682LPV M46MI, I54V, V82A L10I, T12S, I15V, L19V, M36I, R41K, K45KR, L63P, H69K, T74S, I93LC

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