<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype C
Gene PR
Mutation L10F
Rx >= 1 PI
IncludeMixtures No
References 12
Patients 72
Isolates 81
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG8686_w82 NFV65D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
 DMG9191_w22 NFV22D30NL10F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36L, N37E, K45R, D60E, L63P, H69K, I93LC
Grossman (2004)IL370IL370AY529592NFV55D30DN, N88NDGSL10FT12S, L19V, K20KM, M36I, R41K, L63LP, H69K, T74S, L89IM, I93LC
 IL433IL433bAY529601IDV174M46L, V82A, L90LML10F, Q58QEI15V, K20R, M36I, L63PT, H69K, L89M, I93LC
 IL477IL477AY529602NFV208D30NL10F, N88DT12S, I15V, L19V, K20T, E35D, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93LC
Non-B Workgroup (2005)UK1447bUK1447bAY900833IDV, NFV, SQV, RTV, APV, LPV175M46I, I50V, I54V, V82A, L90ML10F, L23I, K43TI15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, A71V, T74S, L89I, I93LC
 SA75_DR16SA75_DR16AY901099NFV D30NL10F, V32VA, N88DI15IL, G16E, L19I, E35D, M36IV, R41K, Y59YF, Q61E, I62IV, H69K, T74S, L89M, I93L, N98KC
 TK1021TK1021 IDV, RTV, LPV331M46I, I54V, V82AL10F, L24I, Q58ET12S, L19I, E35D, M36I, N37D, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, L89M, I93LC
 TK3015TK3015a SQV, IDV, LPV264I54V, V82A, L90ML10F, K43TT12S, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
  TK3015b SQV, IDV, LPV283I54V, V82A, L90ML10F, K43TT12P, I15V, L19K, K20I, E35D, M36I, R41K, D60E, Q61E, L63P, H69K, A71V, I85V, I93LC
 PL4205672786 IDV, RTV275V82AL10F, L24I, I54CT12TS, I13IV, G17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93LC
  91776 IDV, RTV, LPV340V82AL10F, L24I, I54CG17D, L19I, K20R, M36I, R41K, K45R, L63P, H69K, A71V, L89I, I93LC
Rhee (2005)CA7907CA24813AY797580IDV, NFV260D30NL10F, N88DT12P, K14R, I15V, G16E, K20IT, E35G, M36V, R41K, L63T, H69Q, T74S, V77VI, I85IV, L89M, I93LC
Weber (2005)M72003M72003AY677426NFV, RTV, IDV212I54IV, L90ML10FI13V, K14N, I15V, L19I, K20T, E35N, M36I, R41K, K45R, I62IV, L63P, I64V, H69K, K70R, T74S, L89M, I93LC
 F36402F36402AY714443IDV, SQV, Unknown>65M46I, I84V, L90ML10F, T74PI15V, L19I, K20IMT, M36I, R41K, K43R, Q61H, I62V, L63T, I64V, H69K, L89M, I93LC
Baxter (2006)48-24052405-30826DQ877890PINAM46I, V82AL10F, K43T, T74PT12S, I15V, L19T, K20R, M36I, Q61E, I62V, L63P, H69K, L89M, I93LC
 48-32293229-30523DQ878136PINAM46I, I54V, V82A, I84VL10F, L24I, L33F, K43TT12S, I13V, L19I, K20M, E35D, M36I, R41K, L63V, I64V, H69K, T74S, L89I, T91SC
 48-50015001-30415DQ878534PINAM46I, L76V, V82AL10F, L33LFI13IV, I15V, G16A, L19I, E34EQ, M36L, N37S, R41K_K, G51A, K55N, I62V, H69K, T74S, L89I, I93ILC
 48-71017101-30723DQ878954PINAM46I, I54V, V82AL10F, L24IT12P, I13V, L19I, K20I, E35D, M36I, R41K, L63P, H69K, T74AS, L89M, I93LC
 48-93029302-30918DQ877587PINAI54V, V82A, L90ML10F, G73GS, L89IMVI15V, K20I, E35D, M36I, N37K, R41N, Q61H, L63P, H69K, A71V, I85V, I93LC
Doualla-Bell (2006)Pt13FDB_Pt13 NFV D30N, M46IL10F, N88DI15V, M36I, R41K, L63P, H69K, I93LC
 Pt5FDB_Pt5 NFV N88SL10FI15V, L19I, K20T, E35D, M36I, R41K, Q61H, L63T, H69K, T74S, L89M, I93LC
 Pt6FDB_Pt6 NFV M46I, N88SL10FT12S, I15V, L19V, K20I, M36I, R41K, L63V, I64V, H69K, T74V, L89M, I93LC
Pillay (2008)DR37DR37AY589894NFV M46I, N88S, L90ML10FT12S, I13V, I15V, L19I, K20T, M36I, R41K, L63P, H69K, L89I, I93LC
 DR51DR51AY589904IDV78V82TL10FT12S, I15V, L19T, M36L, N37S, K45R, L63P, H69K, L89M, I93L, C95FC
 DR1602ZA.DR16AY589877NFV D30NL10F, V32VA, N88DI15IL, G16E, L19I, E35D, M36IV, R41K, Y59YF, Q61E, I62IV, H69K, T74S, L89M, I93L, N98KC
Sylla (2008)B7173B7173_C1EF525661IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
  B7173_C2EF525662IDV M46I, I84VL10F, T74PT12S, I13V, I15V, L19V, M36I, L63V, I64V, H69K, L89M, I93LC
Barber (2012)6957669576JQ361677LPV I54V, V82AL10FT12S, I15V, L19I, M36I, R41K, L63T, H69K, L89M, I93LC
 5657256572JQ361684LPV V82AL10FI15V, G17D, L19I, M36I, D60E, L63P, H69K, L89M, I93LC
Van Zyl (2013)833156KC423232LPV26V82AL10FT12S, I15V, L19I, M36I, R41K, L63P, H69K, L89M, I93LC
 504904KC424348LPV26I54V, V82AL10F, L33FT12S, I15V, L19T, K20KT, M36IL, R41K, L63P, H69K, L89IM, I93LC
 15672032KC423577LPV26M46L, I54V, L76V, V82AL10FI15V, G16E, L19I, K20R, E35D, M36I, R41K, Q61N, L63H, H69K, L89I, I93LC
 16271466KC423161LPV26I54V, I84VL10F, L23I, G73S, L89VT4S, T12S, I15V, L19I, K20T, E35D, M36I, N37D, R41K, K45V, R57K, L63P, H69K, K70E, A71V, I72IM, P79PS, Q92K, I93LC
 14602908KC423889LPV26M46I, I54V, V82AL10F, L24LI, L33F, T74PI13V, G16E, L19T, K20M, E35D, M36I, R41K, Q61N, L63H, H69K, I72IV, L89M, I93LC
 14532172KC423667LPV26M46I, I54V, V82AL10FT12S, I15V, L19T, K20R, M36I, R41K, K43R, L63V, H69K, L89I, I93LC
 14522906KC423888LPV26M46I, I54V, L76V, V82AL10FT12TS, I15V, L19T, K20R, M36I, R41K, L63V, H69K, L89I, I93LC
 1576168KC423322LPV26M46I, I54V, L76V, V82AL10F, L24I, L33FT12S, I13V, L19T, K20M, E35D, M36I, R41K, Q61N, L63P, H69K, T74S, L89M, I93L, L97IC
 74934KC424377LPV26V82VAL10FT12S, I15V, L19I, M36I, G40GR, R41K, D60E, Q61E, L63LP, H69K, L89M, I93LC
 12001390KC423114LPV26M46L, I54V, V82AL10F, L24LI, L33FI15V, L19I, K20R, E35D, M36I, N37E, R41K, D60E, I62IV, H69K, L89M, I93LC
 1002865KC424321LPV104M46I, I54V, V82AL10FT12P, I15V, G16E, L19P, K20T, M36I, L63T, H69K, I93LC
  2427KC423704LPV208M46I, I54V, L76V, V82AL10FT12P, I15V, G16E, L19P, K20M, M36I, L63T, I64IV, H69K, L89M, I93LC
 402656KC423765LPV26M46I, I54V, V82C, I84VL10FT12S, I15V, L19T, K20R, A22T, M36I, H69K, L89M, I93L, N98KC
 202459KC423723LPV26M46I, I54V, L76V, I84VL10FI15V, L19I, K20R, M36I, R41K, Q61QH, L63PS, H69K, A71V, I93LC
 13933002KC423927LPV130M46I, I54V, V82AL10FT12S, I15V, L19T, K20R, E35D, M36I, R41K, H69K, L89I, I93LC
 16361248KC422997LPV26M46MI, I54V, V82A, L90ML10F, L33F, K43T, G73ST12S, I13V, I15V, L19V, K20R, E35D, M36I, R41K, Q61H, L63P, H69K, K70KR, A71V, I93LC
 17502453KC423718LPV26M46I, I54V, L76V, V82AL10FI15V, L19IT, K20R, E35D, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, H69K, A71V, L89M, I93LC
 16801795KC423414LPV26M46I, I50V, I54V, V82AL10F, L33FT12TS, I15IV, G16E, L19I, K20R, E35D, M36I, R41K, R57K, Q61H, L63S, H69K, A71V, L89M, I93LC
 7071503KC423192LPV26I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, K14R, G16A, M36I, N37D, R41K, L63P, H69K, V77I, L89MC
 15822753KC423813LPV26M46I, I54V, L76V, V82AL10FI13V, G16E, L19I, K20R, M36I, N37Q, R41K, D60E, L63T, H69K, L89M, I93LC
 8441031KC422820LPV78I54V, V82AL10F, L24IT12S, I15V, L19I, E34Q, M36I, R41K, K45R, L63P, H69K, L89M, I93LC
 11281379KC423106LPV26I54V, V82AL10F, L24I, L33F, N83DG16GA, L19I, K20R, E35D, M36I, R41K, L63P, H69K, T74S, I85V, L89I, T91S, I93LC
Grossman (2014)471471KF135082IDV, LPV52M46I, I54V, V82AL10F, L24I, L33FI13V, K14R, I15V, K20KT, M36I, R41K, L63P, H69K, T74TS, L89M, I93LC
 255255KF135031SQV, LPV52I54V, V82AL10F, N88D, L89VT12S, I13V, I15V, L19I, K20R, E35D, M36I, R57K, L63P, H69K, A71V, T74S, I93LC
  255KF135032SQV, LPV90M46I, I54V, V82AL10F, L33F, N88D, L89VT12S, I13V, I15V, L19I, E35D, M36I, N37D, R57K, L63P, H69K, T74S, I93LC
 4949KF135089NFV, LPV52I54V, V82A, L90ML10F, L33F, T74PI13V, I15V, G16E, K20MT, E35N, M36I, R41K, R57K, Q61QHKN, I62IV, L63T, H69K, A71V, I93LC
 633633KF135116RTV, IDV, LPV52I54V, V82AL10FI15V, K20R, E35D, M36I, R41K, I62V, L63P, H69K, T74E, L89M, I93LC
 9797KF135173IDV, LPV52M46I, I54V, V82A, I84V, L90ML10FI13IV, I15V, K20R, M36I, R41K, L63P, H69K, A71V, L89LM, I93LC
  97KF135174IDV, LPV133M46I, I54V, L76V, V82C, I84V, L90ML10FT12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93LC
  97KF135175IDV, LPV228M46I, I54V, L76V, V82C, I84V, L90ML10FT12Q, I15V, K20R, M36I, R41K, L63P, H69K, A71V, I93LC
 354354KF135060SQV, LPV52M46I, I54V, L90ML10F, Q58E, G73A, V82G, L89VW6WL, I15V, L19I, K20T, M36I, R41K, L63LP, H69K, N83H, I85V, I93LC
  354KF135061SQV, LPV128M46I, I54V, V82A, L90ML10F, Q58E, G73A, L89VI15V, L19I, K20T, M36I, R41K, I62V, L63P, H69K, I85V, I93LC
 101101KF134930IDV, LPV156M46L, V82AL10F, L33F, K43T, F53FL, T74PT12S, G16E, L19T, K20R, E35D, M36I, N37NY, R41K, K55R, L63T, E65ED, H69K, L89M, I93LC
 946946KF135166NFV, LPV177M46MI, I54V, L76V, V82AL10FT12S, I15V, L19I, K20R, M36I, N37ND, R41K, K55R, R57RK, I62V, L63P, H69K, A71V, I93LC
 389389KF135067SQV, LPV52I54IV, V82A, L90ML10F, N88NDQ7X, R8~, I15V, L19I, K20KR, M36I, R41K, Q61H, I62V, L63P, H69K, A71V, L89IM, I93LC
 5050KF135091SQV, LPV52M46L, I54V, V82AL10F, L23IT12S, I15V, L19I, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LC
 488488KF135085SQV, LPV52G48A, I54V, V82AL10F, L24I, Q58EK20R, M36I, R41K, L63P, H69K, A71V, I72V, N83S, L89I, I93LC
 943943 LPV379M46I, L90ML10F, N88DT12S, I15V, L19I, K20R, E35D, M36I, R41K, K55R, L63P, H69K, L89M, I93LC
 849849KF135154NFV, LPV134M46I, I54V, L76V, V82AL10F, L33FI13V, I15V, G16E, K20R, M36I, R41K, L63Q, H69K, L89I, I93LC
 781781KF135142IDV, LPV106I54V, V82AL10F, L33FG16E, M36I, R41K, H69K, L89M, I93LC
 465465KF135080IDV, LPV52M46I, I54V, I84V, L90ML10F, Q58E, T74PI13V, I15V, K20V, M36I, R41K, K55R, L63P, H69KR, L89IM, I93LC
 852852KF135155SQV, LPV52M46I, I54V, V82AL10F, L33FL19Q, K20R, G27GR, E35D, M36I, N37ND, P39Q, R41K, I62IV, L63P, H69K, L89M, Q92QK, I93LC
 155155KF134987IDV, LPV52M46I, I54V, V82AL10FI13X, I15V, K20T, M36I, R41K, I62IV, L63P, H69K, T74S, L89M, I93LC
 260260KF135035IDV, LPV384I54V, V82A, L90ML10FI15V, G16E, K20M, M36I, R41K, I62V, L63T, H69K, A71V, T74TS, L89I, I93LC
 20632063KF135018LPV52M46I, I54V, V82AL10F, G73S, L89VT12S, I15V, G16E, L19I, K20I, M36I, N37D, R41K, L63R, H69K, I85V, I93LC
 401401 NFV, LPV52I54V, V82AL10FI15IM, M36AV, R41K, L63P, H69K, A71V, I93LC
 18961896 LPV52V82AL10FI15L, L19I, E34Q, M36I, N37D, R41K, Q61E, L63P, H69K, L89M, I93LC
 952952 IDV, LPV52M46I, I54V, L76V, V82AL10FI15V, K20R, E35ED, M36I, N37D, R41K, R57K, I62V, L63P, I64M, H69K, K70KQ, A71AV, I72IV, L89M, I93LC
 283283 SQV, RTV, IDV, LPV52I54V, V82AL10F, D30DET12S, I13IV, K14R, I15V, K20I, E35D, M36I, Q61H, H69K, T74A, L89I, I93LC
 610610 NFV, IDV, LPV52M46I, I54V, V82A, L90ML10F, T74PST12S, I13V, I15V, L19Q, K20I, E35D, M36I, N37ND, R41K, Q61H, I62V, L63T, I64V, I66L, H69K, L89M, I93LC
  610 NFV, IDV, LPV69M46I, I54V, L76V, V82A, L90ML10FT12S, I13V, I15V, L19Q, K20I, E35D, M36I, R41K, Q61N, I62V, L63T, I64V, I66L, H69K, T74S, L89M, I93L, C95FC