<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation I93M
Rx >= 1 PI
IncludeMixtures No
References 20
Patients 85
Isolates 92
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Rousseau (2000)MNR16MNRMP1305AJ405966SQV, RTV, NFV87I84V, L90M L19I, N37E, L63P, C67Y, H69N, A71V, V77I, Q92K, I93MB
Sevin (2000)SA-231025cSA-231025cAF226129SQV121G48V, I54V, V82C, L90M L10I, L19IM, N37S, L63P, H69Q, A71V, I72IT, I93MB
Shulman (2000)CA1600CA10013AY798402SQV, IDV, RTV92G48V, I54T, V82A L10I, R57K, L63P, I64L, A71V, I72V, I93MB
Kempf (2001)DK-4305DK-4305 IDV, NFV, RTV161M46I, I54V, V82AL24IL10I, K14R, L63P, H69Q, A71V, V77I, I93MB
  6351_d140 IDV, NFV, RTV, LPV181M46I, I54V, V82AL24IL10I, K14R, L63P, H69Q, A71V, I72IV, V77I, I93MB
  6351_d287 IDV, NFV, RTV, LPV202M46I, I54V, V82AL24IL10I, K14R, L63P, H69Q, A71V, I72IV, V77I, I93MB
  6351_d434 IDV, NFV, RTV, LPV223M46I, I54V, V82AL24I, L33LFL10I, K14KR, L63P, H69Q, A71V, I72IV, V77I, I93MB
  6351_d679 IDV, NFV, RTV, LPV258M46I, I54V, V82ASL24I, L33FL10I, K14KR, I62IV, L63P, H69Q, A71V, I72V, V77I, I93MB
Clevenbergh (2002)CP0720CP0720AF519421NFV52M46I, I54V, V82A, L90M W6L, L10LV, K20M, M36V, K55R, R57K, I62V, L63P, H69K, A71I, I93M, C95FB
Gibb (2002)DMG6060_w57 NFV57  I62V, L63P, G68E, H69K, V77I, I93MB
Romano (2002)MZ-pt31pt31-t0AF493366IDV, SQV, RTV G48V, I54V, V82C, I84VQ58EL10I, E35D, M36I, D60E, I62V, L63P, H69N, A71V, V77I, I93MB
  pt31-t1AF493405IDV, SQV, RTV, LPV G48V, I54V, V82C, I84VQ58EL10I, E35D, D60E, I62V, L63P, H69N, A71V, V77I, I93MB
Tural (2002)880509880509 SQV, IDV, NFV204M46I, L90M L10I, L19I, L63P, I64L, A71I, I72K, V77I, V82I, R87S, I93M, C95FB
Monno (2003)ML_Pat70ML_Pat70 PINAM46L, L90M L10R, L63P, C67Y, H69K, A71V, I93MB
 ML_Pat95ML_Pat95 PINAG48V, I54T, V82A, L90M L10I, I13V, K20R, E34K, M36I, R41K, K55KR, I62V, L63P, I64M, H69R, A71V, T74S, I93M, C95FB
Wu (2003)CA1268CA9659AF544449Unknown, SQV, IDV, RTV, NFV>128G48V, I54T, V82A, L90MM46VL10I, I15V, K20R, E35D, M36I, I62V, L63P, A71V, I93MB
Mueller (2004)MSM_pat2MLpat2_a PINAM46I, I54V, L76V, V82A, L90MQ58EL10I, I15V, K20R, M36I, R41K, K55R, R57K, I62V, L63P, A71V, T74KR, L89M, I93MB
Rhee (2005)SWC-60376037-2952 Unknown, IDV>88M46I, I84V, L90M L10I, K20I, E35D, M36I, N37D, L63P, H69Q, A71V, I72V, L89M, Q92R, I93MB
 CA5204CA33687AY797264NFV, SQV, RTV184I84V, L90ML23I, N88DG16A, K20R, M36I, R57K, Q61H, L63P, H69Q, A71I, I93MB
Baxter (2006)12-19281928-30818DQ876004PINAM46I, I54L, I84V, L90ML33LFL10I, N37NS, R41K, F53Y, I62V, L63P, I64V, H69Q, V77I, Q92R, I93M, C95FB
 12-19471947-30527DQ876050PINAV32I, M46I, I47V, I54L, I84V, L90ML33F, G73TL10I, R41RK, L63P, H69HR, K70KR, A71I, I93MB
 12-17671767-30522DQ876073PINAM46I, V82F, I84V, L90MV11I, Q58E, G73CL10I, I15V, K20I, E35D, M36I, F53Y, I62V, L63P, H69Q, A71I, I72L, Q92QK, I93MB
 12-21652165-30821DQ876354PINAG48V, I54T, V82AK43KTL10I, L19LI, K20R, E35D, M36I, N37D, L63P, A71I, I72V, I93MB
 12-20372037-30702DQ876358PINAV32I, M46I, I54V, V82A, L90MG73S, L89VL10IV, I15V, L19I, K20R, M36I, G51A, K55R, L63P, H69Q, A71IV, I93MB
 12-18761876-30529DQ876535PINAM46L, I54V, V82A, L90MQ58EL10IV, K20R, M36I, K55R, L63P, A71V, I72IT, Q92K, I93MB
 12-21392139-30818DQ876544PINAM46L, V82VA, I84V, L90ML33F, F53L, T74PL5V, L10I, I13V, N37D, R41K, I62IV, L63P, A71V, I72IV, I93MB
 12-16111611-30626DQ876752PINAM46I, I50V, I54V, L76V, L90ML10F, G73S, L89LVI15IV, K20I, E34Q, E35D, M36I, N37D, I62V, L63P, H69QR, A71FI, I93MB
 12-17171717-30424DQ876855PINAV32I, M46I, I54V, V82A, L90M L10IV, I13IV, K14KR, K20R, M36I, N37ND, L63P, A71V, I72V, I93MB
 12-15081508-30515DQ876903PINAM46L, G48V, I54T, V82A L10I, K20KR, M36MI, L63P, A71V, I72V, I93MB
 12-16891689-30428DQ876975PINAV32I, I47V, I54V, V82A, L90ML10F, V11VI, L33F, G73S, L89VT12TS, I13V, K14KR, I15V, L19V, K20R, M36I, I62V, L63P, H69Q, A71V, I93MB
 12-12381238-30512DQ877022PINAM46I, I84V, L90ML10FI, Q58E, G73SI62V, L63P, I64L, I66V, H69Q, A71V, I72T, V77I, I93MB
 12-18931893-30611DQ877100PINAM46I, I54IV, V82VCFG, I84V, L90ML10F, Q58E, G73GASTL19I, L63P, H69R, K70R, I93M, C95FB
 12-30273027-30310DQ877238PINAI54V, I84V, L90MG73SL10I, I15V, L19LQ, K20I, E35D, M36I, N37E, R57K, D60DE, I62V, L63P, H69Q, A71I, Q92K, I93MB
 48-12701270-30923DQ877791PINAM46I, I84V, L90MQ58EL10V, L63P, I66V, H69R, I72IT, T74K, L89M, Q92K, I93M, C95FB
 48-20182018-30514DQ877848PINAG48V, I54T, V82AK43KTL10I, N37ND, D60E, Q61DE, L63P, H69HQ, A71I, V77I, I93MB
 48-26162616-30806DQ877906PINAG48V, I50V, I54S, V82A, L90ML33FL10IV, I13V, E34Q, I62V, L63P, I64L, I66IV, H69R, A71L, I72V, V77I, I93MB
 48-26172617-30630DQ877907PINAI54V, V82A, I84V, L90ML23I, K43TL10I, T12E, L19V, K20R, E35D, M36IV, I62V, L63P, H69Q, A71I, Q92K, I93MB
 48-30223022-30313DQ877932PINAI54A, V82F, L90ML33LFL10I, L19I, E34Q, N37D, D60E, I62IV, L63P, I64LV, A71V, V77I, Q92K, I93MB
 48-30973097-30325DQ878004PINAM46L, I54L, L76V, I84V, L90ML10FI13V, K20I, E34K, M36I, K55R, I62V, L63P, H69K, A71V, P79D, I93MB
 48-31423142-30414DQ878053PINAG48V, I54V, V82S, I84V, L90MQ58EL10I, K14KR, I15V, L19I, K20R, M36I, I62V, L63P, H69Q, A71I, I93MB
 48-32603260-30630DQ878164PINAG48V, I50V, I54S, V82A L10I, I15V, L19I, K20R, E35D, M36I, N37DE, I64IV, A71V, I93MB
 48-32623262-30729DQ878166PINAM46I, I54V, I84V, L90MG73SL10I, I15V, Q18H, K20I, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, C67F, H69K, A71V, I85V, Q92E, I93M, C95CGB
 48-32963296-30728DQ878201PINAM46I, I54V, V82A, L90MK43T, G73SL10V, T12K, I15V, L19P, K20M, E34EQ, M36LV, L38W, K55R, R57K, I62V, L63P, H69K, A71L, I93M, C95LB
  3296-40226DQ878202PI, RTV, TPV>30M46I, I54V, V82A, I84V, L90MK43T, G73S, L89VL10V, T12P, I15V, L19P, K20M, E34Q, M36A, K55R, R57K, D60E, I62V, L63P, H69K, A71I, I93M, C95LB
 48-32973297-30930DQ878203PINAM46I, I54V, I84V, L90MG73SL10I, I15V, Q18H, K20I, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, C67F, H69K, A71V, I85V, Q92E, I93M, C95VB
 48-61086108-30930DQ878700PINAM46L, G48A, I54V, V82AL23I, F53L, Q58EL10I, I15V, K20R, E21K, E35D, M36I, N37D, K55R, R57K, I62V, L63V, G68E, H69K, A71V, I93MB
 48-62076207-30715DQ878780PINAV32I, I47V, I54M, L90ML33F, G73S, L89VE34EQ, N37NI, R57KN, L63P, H69K, A71LV, I93MB
 48-62126212-30904DQ878785PINAM46I, G48V, I54S, V82A, I84IV, L90LML33F, K43T, T74PL10I, I13V, K20R, E34Q, M36I, I62V, L63P, H69K, A71V, I93MB
 48-63076307-30924DQ878846PINAL90M L63P, H69K, V77I, I93MB
 48-71407140-30730DQ878978PINAM46I, I54A, V82T, L90M L10V, I15V, L19I, K20R, E35D, M36I, K55R, L63P, H69Q, A71V, Q92K, I93M, C95FB
 48-90859085-30827DQ877657PINAM46I, I54V, V82VA, L90ML33F, G73GSL10I, T12K, I13V, L19I, Q61QH, L63P, E65ED, H69Q, A71AV, V77I, I93MB
 48-91029102-30908DQ877691PINAM46I, I54V, I84V, L90MG73SL10I, Q18H, L19P, K20I, L24F, L33V, M36I, N37S, I62V, L63P, H69L, A71T, I72R, I93MB
 48-80028002-30415DQ879047PINAM46L, G48V, I50V, I54A, V82A, L90ML33FL10I, I13V, N37S, I62V, L63H, A71V, I72V, V77I, I93MB
 48-80038003-30501DQ879048PINAG48V, I54T, V82A, L90ML33F, Q58EL10I, I13V, K20R, E34N, E35D, M36I, N37D, I62V, L63P, A71T, I93MB
Santos (2006)026026PR_RTAY275731RTV, IDV82  N37S, L63P, H69K, V77I, I93MB
Waleria-Aleixo (2008)RES322RES322FJ592008PINAI54V, L90ML10FR8Q, I15V, L19V, K20R, E35D, M36V, N37D, R41K, L63P, A71V, T74S, V75I, I93MB
 08PR05029308PR050293FJ591321PINAI54V, V82A, L90M L10I, L19I, K20R, E35D, M36I, N37E, R57K, L63P, I64M, A71V, I72V, T74S, Q92K, I93MB
Rhee (2009)CA5204CA50796FJ983179NFV, SQV, RTV, LPV304I84V, L90ML10LF, L23I, N88DI13IV, G16A, K20R, M36I, R57K, Q61H, L63P, H69Q, A71I, I93MB
Dau (2010)06070A06070AGU581701PINAV32I, M46I, I47V, I54M, V82A, L90ML33F, K43T, G73TL10I, I13V, E34Q, E35D, M36I, I62V, L63P, H69Q, A71MV, I72V, V77I, I93MB
 06566A06566AGU581761PINAM46I, I54V, V82F, I84V, L90MF53LL10I, I13V, K20I, E35N, M36I, N37S, D60E, L63P, A71V, I93MB
 06908A06908AGU581795PINAM46I, I54IL, I84V, L90ML10FK14R, Q18R, K20I, L63P, H69Q, A71V, Q92R, I93MB
 10256A10256AGU581997PINAM46I, I54V, I84V, L90ML89VL10I, I15V, K20I, E35D, M36I, N37D, L63P, I64IM, H69Q, A71V, I72IV, I85V, T91TCS, Q92QL, I93MB
Jones (2012)158406158406JN669917PINAI84V, L90ML10F, T74PI13V, I15V, K20I, E35G, M36I, I62V, L63P, A71V, I72T, I93MB
 171474171474JN670261PINAG48IM, I54V, V82A, L90ML33LF, F53L, Q58EL10V, K14KR, L19I, R57RK, I62V, L63P, H69Q, A71V, I72V, I93MB
 181449181449JN670577PINAG48V, I54V, V82A, L90M L10I, K14R, L19IV, I62V, L63P, A71IV, V77I, Q92E, I93MB
 184151184151JN670674PINAM46I, I54V, I84V, L90MG73GS, L89LVL10I, K14R, I15V, Q18QH, K20I, E35D, M36I, N37D, I62IV, L63P, H69R, K70E, A71I, Q92K, I93M, C95LB
 190870190870JN670806PINAM46I, I54V, V82F, I84V, L90M L10I, I13V, I15V, K20I, E35D, M36I, N37D, I62V, L63P, A71V, P79A, L89LI, I93MB
Kouri (2012)CU459-10CU459-10JQ585396PINAV32I, M46I, I47V, I54M, V82A, L90ML33F, K43T, Q58ET4P, L10I, I13V, G16E, K20R, E35D, M36I, L63H, K70E, A71V, I72T, I93MB
 CU1009-09CU1009-09JQ585270PINAM46I, I84V, L90MG73AL10I, Q18E, N37S, F53Y, I62V, L63P, H69Q, I72M, V77I, I93M, C95FB
Diaz (2015)RenG15997RenG15997KT747025PINAM46I, I54V, V82A, L90ML10F, L33F, G73TT12K, I13V, L19I, L24F, E34K, K43KQ, I62V, L63P, H69Q, A71V, V77VI, I93MB
 RenG15752RenG15752KT746780PINAM46I, L90MT74PL10IV, I13V, K20T, E34EQ, R41K, I62V, L63P, H69K, A71I, V77I, I93MB
 RenG17489RenG17489KT748517PINAI54V, V82A, L90ML33F, G73SL10I, I13V, G17D, N37T, K45R, L63P, H69K, A71I, I93MB
 RenG17398RenG17398KT748426PINAM46I, I47V, I54V, I84V, L90ML10F, V11VI, F53FL, G73TI13V, Q18H, K20I, M36I, N37D, L63P, H69R, A71I, I93MB
 RenG16978RenG16978KT748006PINAL90M L10V, E35D, M36I, N37E, I62V, L63P, H69K, A71V, I72IT, T74S, V77VI, I93MB
 RenG16751RenG16751KT747779PINAL90M I13V, I15V, K20M, E35D, M36I, R57K, L63P, H69K, A71V, I93MB
 RenG14387RenG14387KT745415PINAI50L, V82M, L90ML33F, K43T, Q58E, G73SI13V, I15V, L19I, K45R, L63P, H69K, A71I, T74S, I93MB
 RenG14390RenG14390KT745418PINAI54V, V82A, L90ML33F, Q58E, T74PL10I, I13V, E35E_ND, M36L, N37K, P39T, I62V, L63P, I64M, H69K, A71V, V75I, I93MB
 RenG14875RenG14875KT745903PINAG48A, I54AV, V82A, L90M L10IV, K20R, E35D, M36I, R41K, K43KN, I62V, L63P, H69Q, A71V, I72V, T74S, Q92K, I93MB
 RenG15441RenG15441KT746469PINAV32I, M46I, I47V, I54M, V82A, L90ML33F, K43TL10V, E34Q, K55R, D60E, L63P, A71I, I93MB
 RenG14697RenG14697KT745725PINAM46L, I54L, I84V, L90ML10F, L33F, T74PI13V, L19T, K20M, E35G, M36I, I62V, L63P, H69Q, A71IV, Q92K, I93MB
 RenG15057RenG15057KT746085PINAI54IV, V82A, L90M L10V, K14R, N37ND, I62IV, L63P, H69Q, A71V, T74TS, V77I, I93MB
 RenG14672RenG14672KT745700PINAM46L, G48V, I54V, V82A, L90MK43KT, Q58EL10V, K20R, E35D, M36I, N37D, R57RK, I62V, L63PT, C67E, H69K, A71V, I93M, L97IB
 RenG14419RenG14419KT745447PINAL90M T12K, I13V, K14R, R41K, K43R, I62V, L63P, I64IM, H69Q, A71V, I72IL, V77I, I93MB
 RenG15007RenG15007KT746035PINAM46I, I47V, I54A, V82F, L90M L10I, G16A, K20R, E35D, M36I, L63P, I64L, H69K, A71V, I93MB
 RenG13340RenG13340KT744368PINAV32I, G48V, I54V, V82A, I84V, L90ML33F, K43IMT, G73SL10I, I13IV, K20R, E34K, E35D, M36I, N37E, L38I, I62V, L63P, A71V, I72V, I93MB
 RenG12487RenG12487KT743515PINA  I13V, K14R, G17N, L19V, K20T, M36I, N37D, D60E, I62IV, L63P, I64V, H69K, A71AV, I72V, T74S, T91TS, I93MB
 RenG13099RenG13099KT744127PINAM46I, I50L, V82A, L90MG73SL10I, I15IV, G16GR, K20I, N37E, R41RK, K45R, Q61H, L63P, H69K, A71I, V77I, I93MB
 RenG13441RenG13441KT744469PINAM46I, I54V, V82A, L90MK43T, F53L, G73TL10I, I13M, K20I, M36I, N37D, K55R, Q61E, I62V, L63P, H69Q, A71I, T74S, I93MB
 RenG12056RenG12056KT743084PINAG48V, I54T, V82A, L90ML33FL10V, I13V, E34Q, I62V, L63P, H69K, A71L, V77VI, T91S, I93MB
 RenG10496RenG10496KT741524PINAV32I, M46I, I47A, L90M I13V, I15V, L19K, K20I, M36V, N37S, R57K, L63P, A71V, V82I, L89I, I93MB
 RenG11387RenG11387KT742415PINAD30N, I54L, L90MK43KT, N88DL10V, I13V, L19LV, K20R, E35D, M36I, N37ST, I62V, L63P, H69Q, A71I, T74S, V77I, I93MB
 RenG10551RenG10551KT741579PINAM46I, I54V, I84V, L90ML10F, G73TL19Q, K20I, L24M, E35D, M36I, K55KR, D60E, Q61DN, I62IV, L63P, I66IV, H69Q, K70KE, A71V, I93MB