Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	I93M
Rx	>= 1 PI
IncludeMixtures	No

References	17
Patients	58
Isolates	65

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Rousseau (2000)	MNR16	MNRMP1305	AJ405966	SQV, RTV, NFV	87	I84V, L90M		L19I, N37E, L63P, C67Y, H69N, A71V, V77I, Q92K, I93M	B
Sevin (2000)	SA-231025c	SA-231025c	AF226129	SQV	121	G48V, I54V, V82C, L90M		L10I, L19IM, N37S, L63P, H69Q, A71V, I72IT, I93M	B
Shulman (2000)	CA1600	CA10013	AY798402	SQV, IDV, RTV	92	G48V, I54T, V82A		L10I, R57K, L63P, I64L, A71V, I72V, I93M	B
Kempf (2001)	DK-4305	DK-4305		IDV, NFV, RTV	161	M46I, I54V, V82A	L24I	L10I, K14R, L63P, H69Q, A71V, V77I, I93M	B
		6351_d140		IDV, NFV, RTV, LPV	181	M46I, I54V, V82A	L24I	L10I, K14R, L63P, H69Q, A71V, I72IV, V77I, I93M	B
		6351_d287		IDV, NFV, RTV, LPV	202	M46I, I54V, V82A	L24I	L10I, K14R, L63P, H69Q, A71V, I72IV, V77I, I93M	B
		6351_d434		IDV, NFV, RTV, LPV	223	M46I, I54V, V82A	L24I, L33LF	L10I, K14KR, L63P, H69Q, A71V, I72IV, V77I, I93M	B
		6351_d679		IDV, NFV, RTV, LPV	258	M46I, I54V, V82AS	L24I, L33F	L10I, K14KR, I62IV, L63P, H69Q, A71V, I72V, V77I, I93M	B
Clevenbergh (2002)	CP0720	CP0720	AF519421	NFV	52	M46I, I54V, V82A, L90M		W6L, L10LV, K20M, M36V, K55R, R57K, I62V, L63P, H69K, A71I, I93M, C95F	B
Gibb (2002)	DMG60	60_w57		NFV	57			I62V, L63P, G68E, H69K, V77I, I93M	B
Romano (2002)	MZ-pt31	pt31-t0	AF493366	IDV, SQV, RTV		G48V, I54V, V82C, I84V	Q58E	L10I, E35D, M36I, D60E, I62V, L63P, H69N, A71V, V77I, I93M	B
		pt31-t1	AF493405	IDV, SQV, RTV, LPV		G48V, I54V, V82C, I84V	Q58E	L10I, E35D, D60E, I62V, L63P, H69N, A71V, V77I, I93M	B
Tural (2002)	880509	880509		SQV, IDV, NFV	204	M46I, L90M		L10I, L19I, L63P, I64L, A71I, I72K, V77I, V82I, R87S, I93M, C95F	B
Monno (2003)	ML_Pat70	ML_Pat70		PI	NA	M46L, L90M		L10R, L63P, C67Y, H69K, A71V, I93M	B
	ML_Pat95	ML_Pat95		PI	NA	G48V, I54T, V82A, L90M		L10I, I13V, K20R, E34K, M36I, R41K, K55KR, I62V, L63P, I64M, H69R, A71V, T74S, I93M, C95F	B
Wu (2003)	CA1268	CA9659	AF544449	Unknown, SQV, IDV, RTV, NFV	>128	G48V, I54T, V82A, L90M	M46V	L10I, I15V, K20R, E35D, M36I, I62V, L63P, A71V, I93M	B
Mueller (2004)	MSM_pat2	MLpat2_a		PI	NA	M46I, I54V, L76V, V82A, L90M	Q58E	L10I, I15V, K20R, M36I, R41K, K55R, R57K, I62V, L63P, A71V, T74KR, L89M, I93M	B
Rhee (2005)	SWC-6037	6037-2952		Unknown, IDV	>88	M46I, I84V, L90M		L10I, K20I, E35D, M36I, N37D, L63P, H69Q, A71V, I72V, L89M, Q92R, I93M	B
	CA5204	CA33687	AY797264	NFV, SQV, RTV	184	I84V, L90M	L23I, N88D	G16A, K20R, M36I, R57K, Q61H, L63P, H69Q, A71I, I93M	B
Baxter (2006)	12-1928	1928-30818	DQ876004	PI	NA	M46I, I54L, I84V, L90M	L33LF	L10I, N37NS, R41K, F53Y, I62V, L63P, I64V, H69Q, V77I, Q92R, I93M, C95F	B
	12-1947	1947-30527	DQ876050	PI	NA	V32I, M46I, I47V, I54L, I84V, L90M	L33F, G73T	L10I, R41RK, L63P, H69HR, K70KR, A71I, I93M	B
	12-1767	1767-30522	DQ876073	PI	NA	M46I, V82F, I84V, L90M	V11I, Q58E, G73C	L10I, I15V, K20I, E35D, M36I, F53Y, I62V, L63P, H69Q, A71I, I72L, Q92QK, I93M	B
	12-2165	2165-30821	DQ876354	PI	NA	G48V, I54T, V82A	K43KT	L10I, L19LI, K20R, E35D, M36I, N37D, L63P, A71I, I72V, I93M	B
	12-2037	2037-30702	DQ876358	PI	NA	V32I, M46I, I54V, V82A, L90M	G73S, L89V	L10IV, I15V, L19I, K20R, M36I, G51A, K55R, L63P, H69Q, A71IV, I93M	B
	12-1876	1876-30529	DQ876535	PI	NA	M46L, I54V, V82A, L90M	Q58E	L10IV, K20R, M36I, K55R, L63P, A71V, I72IT, Q92K, I93M	B
	12-2139	2139-30818	DQ876544	PI	NA	M46L, V82VA, I84V, L90M	L33F, F53L, T74P	L5V, L10I, I13V, N37D, R41K, I62IV, L63P, A71V, I72IV, I93M	B
	12-1611	1611-30626	DQ876752	PI	NA	M46I, I50V, I54V, L76V, L90M	L10F, G73S, L89LV	I15IV, K20I, E34Q, E35D, M36I, N37D, I62V, L63P, H69QR, A71FI, I93M	B
	12-1717	1717-30424	DQ876855	PI	NA	V32I, M46I, I54V, V82A, L90M		L10IV, I13IV, K14KR, K20R, M36I, N37ND, L63P, A71V, I72V, I93M	B
	12-1508	1508-30515	DQ876903	PI	NA	M46L, G48V, I54T, V82A		L10I, K20KR, M36MI, L63P, A71V, I72V, I93M	B
	12-1689	1689-30428	DQ876975	PI	NA	V32I, I47V, I54V, V82A, L90M	L10F, V11VI, L33F, G73S, L89V	T12TS, I13V, K14KR, I15V, L19V, K20R, M36I, I62V, L63P, H69Q, A71V, I93M	B
	12-1238	1238-30512	DQ877022	PI	NA	M46I, I84V, L90M	L10FI, Q58E, G73S	I62V, L63P, I64L, I66V, H69Q, A71V, I72T, V77I, I93M	B
	12-1893	1893-30611	DQ877100	PI	NA	M46I, I54IV, V82VCFG, I84V, L90M	L10F, Q58E, G73GAST	L19I, L63P, H69R, K70R, I93M, C95F	B
	12-3027	3027-30310	DQ877238	PI	NA	I54V, I84V, L90M	G73S	L10I, I15V, L19LQ, K20I, E35D, M36I, N37E, R57K, D60DE, I62V, L63P, H69Q, A71I, Q92K, I93M	B
	48-1270	1270-30923	DQ877791	PI	NA	M46I, I84V, L90M	Q58E	L10V, L63P, I66V, H69R, I72IT, T74K, L89M, Q92K, I93M, C95F	B
	48-2018	2018-30514	DQ877848	PI	NA	G48V, I54T, V82A	K43KT	L10I, N37ND, D60E, Q61DE, L63P, H69HQ, A71I, V77I, I93M	B
	48-2616	2616-30806	DQ877906	PI	NA	G48V, I50V, I54S, V82A, L90M	L33F	L10IV, I13V, E34Q, I62V, L63P, I64L, I66IV, H69R, A71L, I72V, V77I, I93M	B
	48-2617	2617-30630	DQ877907	PI	NA	I54V, V82A, I84V, L90M	L23I, K43T	L10I, T12E, L19V, K20R, E35D, M36IV, I62V, L63P, H69Q, A71I, Q92K, I93M	B
	48-3022	3022-30313	DQ877932	PI	NA	I54A, V82F, L90M	L33LF	L10I, L19I, E34Q, N37D, D60E, I62IV, L63P, I64LV, A71V, V77I, Q92K, I93M	B
	48-3097	3097-30325	DQ878004	PI	NA	M46L, I54L, L76V, I84V, L90M	L10F	I13V, K20I, E34K, M36I, K55R, I62V, L63P, H69K, A71V, P79D, I93M	B
	48-3142	3142-30414	DQ878053	PI	NA	G48V, I54V, V82S, I84V, L90M	Q58E	L10I, K14KR, I15V, L19I, K20R, M36I, I62V, L63P, H69Q, A71I, I93M	B
	48-3260	3260-30630	DQ878164	PI	NA	G48V, I50V, I54S, V82A		L10I, I15V, L19I, K20R, E35D, M36I, N37DE, I64IV, A71V, I93M	B
	48-3262	3262-30729	DQ878166	PI	NA	M46I, I54V, I84V, L90M	G73S	L10I, I15V, Q18H, K20I, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, C67F, H69K, A71V, I85V, Q92E, I93M, C95CG	B
	48-3296	3296-30728	DQ878201	PI	NA	M46I, I54V, V82A, L90M	K43T, G73S	L10V, T12K, I15V, L19P, K20M, E34EQ, M36LV, L38W, K55R, R57K, I62V, L63P, H69K, A71L, I93M, C95L	B
		3296-40226	DQ878202	PI, RTV, TPV	>30	M46I, I54V, V82A, I84V, L90M	K43T, G73S, L89V	L10V, T12P, I15V, L19P, K20M, E34Q, M36A, K55R, R57K, D60E, I62V, L63P, H69K, A71I, I93M, C95L	B
	48-3297	3297-30930	DQ878203	PI	NA	M46I, I54V, I84V, L90M	G73S	L10I, I15V, Q18H, K20I, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, C67F, H69K, A71V, I85V, Q92E, I93M, C95V	B
	48-6108	6108-30930	DQ878700	PI	NA	M46L, G48A, I54V, V82A	L23I, F53L, Q58E	L10I, I15V, K20R, E21K, E35D, M36I, N37D, K55R, R57K, I62V, L63V, G68E, H69K, A71V, I93M	B
	48-6207	6207-30715	DQ878780	PI	NA	V32I, I47V, I54M, L90M	L33F, G73S, L89V	E34EQ, N37NI, R57KN, L63P, H69K, A71LV, I93M	B
	48-6212	6212-30904	DQ878785	PI	NA	M46I, G48V, I54S, V82A, I84IV, L90LM	L33F, K43T, T74P	L10I, I13V, K20R, E34Q, M36I, I62V, L63P, H69K, A71V, I93M	B
	48-6307	6307-30924	DQ878846	PI	NA	L90M		L63P, H69K, V77I, I93M	B
	48-7140	7140-30730	DQ878978	PI	NA	M46I, I54A, V82T, L90M		L10V, I15V, L19I, K20R, E35D, M36I, K55R, L63P, H69Q, A71V, Q92K, I93M, C95F	B
	48-9085	9085-30827	DQ877657	PI	NA	M46I, I54V, V82VA, L90M	L33F, G73GS	L10I, T12K, I13V, L19I, Q61QH, L63P, E65ED, H69Q, A71AV, V77I, I93M	B
	48-9102	9102-30908	DQ877691	PI	NA	M46I, I54V, I84V, L90M	G73S	L10I, Q18H, L19P, K20I, L24F, L33V, M36I, N37S, I62V, L63P, H69L, A71T, I72R, I93M	B
	48-8002	8002-30415	DQ879047	PI	NA	M46L, G48V, I50V, I54A, V82A, L90M	L33F	L10I, I13V, N37S, I62V, L63H, A71V, I72V, V77I, I93M	B
	48-8003	8003-30501	DQ879048	PI	NA	G48V, I54T, V82A, L90M	L33F, Q58E	L10I, I13V, K20R, E34N, E35D, M36I, N37D, I62V, L63P, A71T, I93M	B
Santos (2006)	026	026PR_RT	AY275731	RTV, IDV	82			N37S, L63P, H69K, V77I, I93M	B
Rhee (2009)	CA5204	CA50796	FJ983179	NFV, SQV, RTV, LPV	304	I84V, L90M	L10LF, L23I, N88D	I13IV, G16A, K20R, M36I, R57K, Q61H, L63P, H69Q, A71I, I93M	B
Dau (2010)	06070A	06070A	GU581701	PI	NA	V32I, M46I, I47V, I54M, V82A, L90M	L33F, K43T, G73T	L10I, I13V, E34Q, E35D, M36I, I62V, L63P, H69Q, A71MV, I72V, V77I, I93M	B
	06566A	06566A	GU581761	PI	NA	M46I, I54V, V82F, I84V, L90M	F53L	L10I, I13V, K20I, E35N, M36I, N37S, D60E, L63P, A71V, I93M	B
	06908A	06908A	GU581795	PI	NA	M46I, I54IL, I84V, L90M	L10F	K14R, Q18R, K20I, L63P, H69Q, A71V, Q92R, I93M	B
	10256A	10256A	GU581997	PI	NA	M46I, I54V, I84V, L90M	L89V	L10I, I15V, K20I, E35D, M36I, N37D, L63P, I64IM, H69Q, A71V, I72IV, I85V, T91TCS, Q92QL, I93M	B
Jones (2012)	158406	158406	JN669917	PI	NA	I84V, L90M	L10F, T74P	I13V, I15V, K20I, E35G, M36I, I62V, L63P, A71V, I72T, I93M	B
	171474	171474	JN670261	PI	NA	G48IM, I54V, V82A, L90M	L33LF, F53L, Q58E	L10V, K14KR, L19I, R57RK, I62V, L63P, H69Q, A71V, I72V, I93M	B
	181449	181449	JN670577	PI	NA	G48V, I54V, V82A, L90M		L10I, K14R, L19IV, I62V, L63P, A71IV, V77I, Q92E, I93M	B
	184151	184151	JN670674	PI	NA	M46I, I54V, I84V, L90M	G73GS, L89LV	L10I, K14R, I15V, Q18QH, K20I, E35D, M36I, N37D, I62IV, L63P, H69R, K70E, A71I, Q92K, I93M, C95L	B
	190870	190870	JN670806	PI	NA	M46I, I54V, V82F, I84V, L90M		L10I, I13V, I15V, K20I, E35D, M36I, N37D, I62V, L63P, A71V, P79A, L89LI, I93M	B

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