<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation L90M
Rx PI-naive
IncludeMixtures No
References 44
Patients 126
Isolates 132
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Tanuri (1999)BRAM-27BRAM-27AF076446None L90M I13V, M36I, L63P, I72T, I85S, Q92HB
Gonzales (2001)CA1817CA4874AY030731None L90M L10I, I13V, K20T, R57RK, L63A, A71VB
 CA5375CA13261AY031930None L90M L10I, N37NT, L63P, I64L, A71I, V77IB
 CA6604CA16553AY032509None L90M L63P, I72V, V77IB
Clevenbergh (2002)CP1201CP1201AF519439None L90M E35D, M36I, N37S, R41K, I62IV, L63P, I64V, I93LB
Hanna (2003)HG034HG034AY049659None L90M L19V, L63P, I72M, V77IB
Shafer (2003)A384_17681768aEF548787None L90ML33IL19Q, M36I, I62V, L63P, K70R, A71T, I72TB
Gulick (2004)RG171RG171w0 None L90M I13V, E35D, N37S, L63P, A71V, I72M, V77I, I93LB
 RG197RG197w0 None L90M T12K, L19I, M36I, I62V, L63HB
 RG198RG198w0 None L90M L63P, V77I, I93LB
  RG198w60 None L90M L63P, V77I, I93LB
 RG277RG277w0 None L90M I13V, M36I, R41K, R57K, D60E, I62V, L63P, I64V, K70RB
  RG277w22 None L90ML33LII13V, M36I, R41K, R57K, D60E, I62V, L63P, I64V, K70RB
 RG450RG450w0 None L90M E35D, M36I, I62IV, L63PB
  RG450w23 None L90M E35D, M36I, I62V, L63PB
Garcia-Bujalance (2005)GBS_18GBS_18AY872299None L90M R57RK, L63P, A71V, I72E, V77I, I93LB
Lama (2006)Pt33223322 None L90M L10I, L19I, M36MI, R57RK, L63P, I93LB
 Pt40434043 None L90M T12S, L19Q, R41K, L63P, I93LB
Santos (2006)PA237PA237DQ343996None L90M K20R, R41K, D60E, L63P, V77IB
 B060PRB060PRDQ190969None L90M  B
 B042PRB042PRDQ190984None L90M L10I, E35D, L63A, A71V, V77I, I93LB
 PA111PA111DQ343965None L90M Q2KB
 PA169PA169DQ343972None L90M M36I, N37S, R41K, I62V, L63A, T74SB
Brumme (2007)1258PR_1258EF368568None L90M L10R, A28AS, N37S, L63P, I64VB
 1501PRRT_1501EF368811None L90M N37S, R41K, L63P, I64V, E65DB
Dilernia (2007)N04N04EF120267None L90M L10I, L63P, I93LB
Lin (2007)4V1004V100EF078161None L90M I15V, Q18L, K20R, N37D, L63P, A71T, V77I, I93LB
Parker (2007)RW0507bRW0507bAY701363None L90M E35D, M36I, N37E, R41RK, D60E, L63P, I64V, I93LB
Vicenti (2007)398454929REF376618None L90ML89VL10I, K14R, I15V, Q18H, L19Q, K20I, M36I, L63P, A71TB
Chang (2008)TW216TW216EU164856None L90M I15V, Q18L, N37D, L63P, A71T, V77I, I93LB
 TW10365TW10365EU164869None L90M I15V, Q18L, K20T, N37D, L63P, A71I, V77I, I93LB
 TW1974TW1974EU164886None L90M L5S, L63P, K70T, A71V, I93LB
 TW2926TW2926EU164888None L90M L10I, K14R, Q18L, N37D, L63P, A71T, V77VI, I93LB
Holguin (2008)SP70-372830SP70-372830EU255555None L90M L10V, K20M, M36I, L63P, I64V, I93LB
Ibe (2008)134134AB428552None L90M R41K, D60E, I62V, L63P, I93LB
Lloyd (2008)CR04203HN_CR042EU312651None L90M L10I, I13V, K14R, I15V, N37E, L63P, I64V, I72V, V77I, I93LB
Palacios (2008)1277712777 None L90M W6L, L63P, V77I, L97*B
Brennan (2009)N11ARC-N11EU711484None L90M N37S, R41K, L63P, V77I, I93LB
Brown (2009)CAS_749_16_33349CAS_749_16_33349FJ030789None L90M T12P, K14R, L19I, E35D, N37E, K43R, L63A, A71T, V77I, I93LB
 CAS_70_1_7172CAS_70_1_7172FJ030781None L90M I13V, E35D, L63P, I64V, V77I, L89LRB
 CAS_111_1_7597CAS_111_1_7597FJ030655None L90M L10I, E35D, M36I, N37T, I62V, L63P, T74SB
Brumme (2009)G8500G8500GQ371902None L90M E35G, M36I, I62V, L63PB
 H8523H8523GQ371926None L90M I62V, L63P, I64M, A71V, P79AB
 M8528M8528GQ372020None L90M L10I, I15V, L19I, M36I, N37E, R57K, D60E, L63P, H69K, I85VB
Cuevas (2009)P1209P1209.1EU822600None L90M L10I, I15V, E35D, M36I, I62V, L63T, I64V, C67S, I93LB
 P1626P1626.1EU822721None L90M I13V, I15V, I62V, L63S, I64V, V77IB
 P0036P0036.1EU822773None L90M L10I, I15V, E35D, M36I, R57K, L63P, I93LB
 P0556P0556.3EU822776None L90M L10I, I15V, E35D, M36I, I62V, L63T, I64V, C67S, I72IV, I93LB
Rhee (2009)CA20997CA48303FJ983459None L90M I13V, N37D, I62V, L63P, I64V, C67Y, V77IB
Smith (2009)PI11US2001PI11 None L90M K14R, L19I, L63P, A71T, I72V, I93LB
 PI172US2004PI172 None L90M Q61DE, I62IV, L63APS, I64IL, A71T, V77I, I93ILB
 PI226US2005PI226 None L90M L10I, T12P, R41K, L63P, I93LB
 PI229US2005PI229 None L90M L10I, T12P, K14R, R41K, L63P, I93LB
 PI322US2002PI322 None L90M E35D, M36I, I62V, L63PB
 CR51US2007CR51 None L90M R57K, L63P, K70KR, V77IB
 CR119US2006CR119 None L90M Q61E, I62V, L63P, I64L, A71T, V77I, I93ILB
 CR249US2006CR249 None L90M I15V, K20I, P39T, L63P, A71AITV, V77I, I93ILB
Vercauteren (2009)pt2124552060772GQ398900None L90M E35D, I62V, L63P, Q92QE, I93ILB
 pt18712032999465GQ399153None L90M T12P, K14R, L19I, E35D, N37E, K43R, I62V, L63A, A71T, V77I, I93LB
 pt13724x8zRXPiiaGQ399652None L90M L19I, N37S, P39S, I62V, L63P, H69HQ, A71V, V77I, I93LB
 pt7128847015175GQ400312None L90M T12P, K14R, L19I, E35D, N37E, K43R, I62V, L63A, A71T, V77I, I93LB
 pt61792J4VmlBq7GQ400407None L90M L19I, N37S, I62V, L63P, I64M, H69Q, A71V, I93LB
 pt57894CzehKRvVGQ400446None L90M T12P, K14R, L63P, V77I, I93LB
 pt332JFbXgs9qR4GQ400692None L90M L19I, N37NS, I62V, L63P, H69Q, A71V, V77I, I93LB
 pt79VPbr4gk1nlGQ400945None L90M L19I, E34EQ, N37RS, Y59YH, I62V, L63P, H69Q, A71V, V77VI, I93LB
Wang (2009)CR0339XCR0339XFJ469721None L90M M36I, N37T, R57K, I62V, L63PB
Bonura (2010)1080_121080_12GU969498None L90M L10I, N37ND, D60E, I62V, L63P, V77I, I93LB
 1132_971132_97GU969512None L90M I13V, G16A, K20V, N37D, R57RK, I62IV, I64IL, H69K, K70R, A71V, V77IB
Ragonnet-Cronin (2010)PHAC_156PHAC_156HM468654None L90ML33II13V, K14R, L63P, I93LB
 PHAC_219PHAC_219HM468717None L90M I13V, I15V, K20T, E35G, M36I, N37S, R57K, Q61N, L63P, I64V, T74S, V82I, I93LB
 PHAC_229PHAC_229HM468727None L90M L10I, L19I, E35D, M36I, N37E, L63P, V77VI, I93LB
 PHAC_370PHAC_370HM468868None L90M E35D, N37D, D60E, I62V, L63P, I93LB
 PHAC_467PHAC_467HM468965None L90M E35D, N37D, D60E, I62V, L63P, I93LB
 PHAC_533PHAC_533HM469031None L90M T12TP, D25DN, E35D, M36I, N37D, D60E, Q61D, I62V, L63P, I93LB
 PHAC_593PHAC_593HM469091None L90M K14KR, N37D, R41RK, R57RK, I62V, L63H, A71T, I72V, V77IB
 PHAC_736PHAC_736HM469234None L90ML33II13V, L63P, A71V, I72T, I93LB
 PHAC_845PHAC_845HM469343None L90M E35D, M36I, R57K, L63P, I64V, I93LB
 PHAC_856PHAC_856HM469354None L90M T12P, E35D, M36I, N37S, R57K, L63P, I64V, I93LB
Yebra (2010)22414004SP0224140FJ481755None L90M N37S, I62IV, L63PB
 24393705SP0243937FJ481804None L90M I13V, N37D, R41K, R57RK, D60E, Q61E, I62V, L63P, E65D, A71V, V77I, I93LB
Chibo (2011)S178S178JF895365None L90M T12P, K14R, L19I, E35D, N37E, K43R, R57K, L63T, A71T, I72V, V77I, I93LB
Ferreira (2011)BRMT2358BRMT2358HQ638792None L90M L10V, E35D, M36I, N37D, L63P, A71T, I93LB
Kao (2011)Pat17535934HQ657865None L90M I15V, Q18IL, K20T, N37D, R57K, L63P, A71V, V77I, I93LB
 Pat12336329HQ657917None L90M I15V, Q18L, K20T, N37D, R57K, L63P, A71V, V77I, I93LB
Truong (2011)0700150807001508 None L90M L10I, L63D, I64L, A71T, I72K, V77I, I93LB
 0600113806001138 None L90M I62V, L63P, A71V, I72V, V77I, I93LB
 0600131606001316 None L90M I13V, Q18I, E35D, N37D, D60E, L63P, I64V, V77IB
Avila-Rios (2012)JI00M79LXOJI00M79LXOKC169134None L90M T12P, K14R, L63P, V77I, I93LB
 PEI0M63RXEPEI0M63RXEKC169590None L90M L10I, I15V, G16A, E35D, M36I, R41K, I62V, L63P, I64IL, I93LB
 V2I0MB1RSYV2I0MB1RSYKC169717None L90M E35D, M36I, R41K, I62V, L63T, A71V, I93LB
 D2INM86MSQD2INM86MSQKC168419None L90M I3A, T12TS, P39S, R57K, I62V, L63P, I64L, A71V, V77I, I93LB
 B24EM6AFT1B24EM6AFT1KC168143None L90M L10I, I13V, I15V, K20I, M36I, R41K, L63P, C67D, A71V, I93LB
 E15EM95IWLE15EM95IWLKC168663None L90M L10I, K14R, I15V, K20T, E35N, M36I, P39T, R41K, I62V, L63P, A71T, I72V, I93LB
 E2EIM79LXAE2EIM79LXAKC168724None L90M L10V, I15V, N37D, R57K, D60E, L63P, A71V, V77I, I93LB
 E2IQM84NUCE2IQM84NUCKC168726None L90M R57K, L63P, I64L, A71V, I72E, V77I, I93LB
 E2IWMD0OSDE2IWMD0OSDKC168727None L90M R57K, L63P, I64L, A71V, V77I, I93LB
 J1BEM9AISSJ1BEM9AISSKC169030None L90M L10LI, K20KM, E35D, M36I, R57K, I62V, L63P, A71T, I72V, I93LB
Mollan (2012)MK141MK141w-1 None L90M E35D, M36MI, I62V, L63P, I72LB
 MK158MK158w0 None L90M L10I, M36I, P39S, K45R, Q61E, L63D, A71T, I72K, V77I, I93LB
  MK158w30 None L90M L10I, M36I, P39S, K45R, Q61E, L63D, A71T, I72K, V77I, I93LB
Ragonnet-Cronin (2012)A10_146A10_146JX014737None L90ML33II13V, R41K, L63P, A71V, I93LB
Brooks (2013)CAN2013-188CAN13-188KF727761None L90M L10I, L19T, E35D, M36I, R41K, R57K, L63P, A71T, I93LB
 CAN2013-031CAN13-031KF727855None L90ML33II13V, R41K, L63P, A71V, I93LB
 CAN2013-035CAN13-035KF727853None L90M I13V, N37E, K45R, L63T, H69Y, A71V, V77I, I93LB
 CAN2013-050CAN13-050KF727854None L90ML33II13V, E35EQ, N37D, R41RK, W42W*CY, K43R, L63P, A71V, I72T, I93LB
 CAN2013-051CAN13-051KF727856None L90ML33IT12A, I13V, N37D, L63P, A71V, I93LB
Ferreira (2013)BR09SP355BR09SP355HM534181None L90M L10I, L19V, L63S, I72V, V77I, I93LB
Frentz (2013)EHR-01797EHR-01797JX299572None L90M I13V, M36I, N37D, I62IV, L63H, I64L, A71V, I72T, I93LB
 EHR-45678EHR-45678JX300300None L90M I13V, I15V, E35D, M36I, R41K, I62V, L63S, I64L, A71V, I93LB
 EHR-54354EHR-54354JX300445None L90ML33FL10I, I13V, G16E, K43KR, I62V, L63S, A71T, V75I, I93LB
 EHR-62467EHR-62467JX300582None L90M L10I, T12TI, R41K, D60E, I62V, L63P, I72M, V77I, I93LB
 EHR-95577EHR-95577JX301115None L90M T12P, K14R, L19I, E35D, N37E, K43R, I62V, L63A, A71T, V77I, I93LB
Hawke (2013)2095976820959768KC238056None L90M L10I, N37S, R41K, L63D, A71T, I72K, V77I, I93LB
 3594043 H3594043 HKC238130None L90MQ58EL10I, K20I, M36V, N37S, R57K, I62V, L63Q, I64V, T74SB
 3651991 H3651991 HKC238134None L90MQ58QEL10LI, K20IM, M36V, I62V, L63Q, I64V, T74S, V75VI, F99FLB
 5496126 H5496126 HKC238178None L90MQ58EL10I, I13IV, K20I, M36V, R41RK, I62V, L63Q, I64V, T74SB
 5799833 H5799833 HKC238186None L90M L33V, L63Q, I64VB
Heipertz (2013)306340_RT306340_RTJX863947None L90M T12S, I13V, L19I, K20I, Q61H, L63P, K70E, A71V, V77IB
 306415_RT306415_RTJX863957None L90M T12S, I13V, L19I, K20I, Q61H, L63P, K70E, A71V, V77IB
Meixenberger (2014)09-0139909-01399KJ770992None L90M L19I, N37S, I62V, L63P, I64M, H69Q, A71V, V75I, V77I, I93LB
 03-0029303-00293KJ769835None L90M L19I, N37S, P39S, I62V, L63P, H69HQ, A71V, V77I, I93LB
 03-0033803-00338KJ769844None L90M L19I, E34EQ, N37RS, Y59YH, I62V, L63P, H69Q, A71V, V77VI, I93LB
 09-0442809-04428KJ771179None L90M I13V, L19IT, M36MI, R57K, L63P, I64M, A71V, V77VI, I93LB
 03-0026003-00260KJ769824None L90M L19I, N37NS, I62V, L63P, H69Q, A71V, V77I, I93LB
 10-0237010-02370KJ771354None L90M L19I, N37S, R41G, I62V, L63P, I64M, H69Q, A71V, V75I, V77I, I93LB
 12-0398912-03989KJ771840None L90M L10I, T12P, L19T, L33LV, N37S, P39Q, I62V, L63P, A71TB
 09-0373309-03733KJ771134None L90M L10I, E35D, N37D, L63P, I93LB
 08-0123208-01232KJ770733None L90M I13V, L19I, R57K, L63P, I64M, A71V, I93LB
 05-0012605-00126KJ769991None L90M L19I, N37NS, P39PS, I62V, L63P, A71V, I72IT, V77I, I93LB
Porter (2014)STaR1STaR1_B None L90M I13V, L19I, K20T, E35G, M36I, R41K, R57G, I62V, L63T, I64V, I72T, T74S, V77IB
  STaR1_WK12 None L90M I13V, L19T, K20T, E35G, M36I, R41K, R57G, I62V, L63T, I64V, I72T, T74S, V77IB
  STaR1_WK24 None L90M I13V, L19IT, K20T, E35G, M36I, R41K, R57G, I62V, L63T, I64V, I72T, T74S, V77IB