Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	L90M
Rx	PI-naive
IncludeMixtures	No

References	39
Patients	106
Isolates	109

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Tanuri (1999)	BRAM-27	BRAM-27	AF076446	None	L90M		I13V, M36I, L63P, I72T, I85S, Q92H	B
Gonzales (2001)	CA1817	CA4874	AY030731	None	L90M		L10I, I13V, K20T, R57RK, L63A, A71V	B
	CA5375	CA13261	AY031930	None	L90M		L10I, N37NT, L63P, I64L, A71I, V77I	B
	CA6604	CA16553	AY032509	None	L90M		L63P, I72V, V77I	B
Clevenbergh (2002)	CP1201	CP1201	AF519439	None	L90M		E35D, M36I, N37S, R41K, I62IV, L63P, I64V, I93L	B
Hanna (2003)	HG034	HG034	AY049659	None	L90M		L19V, L63P, I72M, V77I	B
Shafer (2003)	A384_1768	1768a	EF548787	None	L90M	L33I	L19Q, M36I, I62V, L63P, K70R, A71T, I72T	B
Gulick (2004)	RG171	RG171w0		None	L90M		I13V, E35D, N37S, L63P, A71V, I72M, V77I, I93L	B
	RG197	RG197w0		None	L90M		T12K, L19I, M36I, I62V, L63H	B
	RG198	RG198w0		None	L90M		L63P, V77I, I93L	B
		RG198w60		None	L90M		L63P, V77I, I93L	B
	RG277	RG277w0		None	L90M		I13V, M36I, R41K, R57K, D60E, I62V, L63P, I64V, K70R	B
		RG277w22		None	L90M	L33LI	I13V, M36I, R41K, R57K, D60E, I62V, L63P, I64V, K70R	B
	RG450	RG450w0		None	L90M		E35D, M36I, I62IV, L63P	B
		RG450w23		None	L90M		E35D, M36I, I62V, L63P	B
Garcia-Bujalance (2005)	GBS_18	GBS_18	AY872299	None	L90M		R57RK, L63P, A71V, I72E, V77I, I93L	B
Lama (2006)	Pt3322	3322		None	L90M		L10I, L19I, M36MI, R57RK, L63P, I93L	B
	Pt4043	4043		None	L90M		T12S, L19Q, R41K, L63P, I93L	B
Santos (2006)	PA237	PA237	DQ343996	None	L90M		K20R, R41K, D60E, L63P, V77I	B
	B060PR	B060PR	DQ190969	None	L90M			B
	B042PR	B042PR	DQ190984	None	L90M		L10I, E35D, L63A, A71V, V77I, I93L	B
	PA111	PA111	DQ343965	None	L90M		Q2K	B
	PA169	PA169	DQ343972	None	L90M		M36I, N37S, R41K, I62V, L63A, T74S	B
Brumme (2007)	1258	PR_1258	EF368568	None	L90M		L10R, A28AS, N37S, L63P, I64V	B
	1501	PRRT_1501	EF368811	None	L90M		N37S, R41K, L63P, I64V, E65D	B
Dilernia (2007)	N04	N04	EF120267	None	L90M		L10I, L63P, I93L	B
Lin (2007)	4V100	4V100	EF078161	None	L90M		I15V, Q18L, K20R, N37D, L63P, A71T, V77I, I93L	B
Parker (2007)	RW0507b	RW0507b	AY701363	None	L90M		E35D, M36I, N37E, R41RK, D60E, L63P, I64V, I93L	B
Vicenti (2007)	3984	54929R	EF376618	None	L90M	L89V	L10I, K14R, I15V, Q18H, L19Q, K20I, M36I, L63P, A71T	B
Chang (2008)	TW216	TW216	EU164856	None	L90M		I15V, Q18L, N37D, L63P, A71T, V77I, I93L	B
	TW10365	TW10365	EU164869	None	L90M		I15V, Q18L, K20T, N37D, L63P, A71I, V77I, I93L	B
	TW1974	TW1974	EU164886	None	L90M		L5S, L63P, K70T, A71V, I93L	B
	TW2926	TW2926	EU164888	None	L90M		L10I, K14R, Q18L, N37D, L63P, A71T, V77VI, I93L	B
Holguin (2008)	SP70-372830	SP70-372830	EU255555	None	L90M		L10V, K20M, M36I, L63P, I64V, I93L	B
Ibe (2008)	134	134	AB428552	None	L90M		R41K, D60E, I62V, L63P, I93L	B
Lloyd (2008)	CR042	03HN_CR042	EU312651	None	L90M		L10I, I13V, K14R, I15V, N37E, L63P, I64V, I72V, V77I, I93L	B
Palacios (2008)	12777	12777		None	L90M		W6L, L63P, V77I, L97*	B
Brennan (2009)	N11	ARC-N11	EU711484	None	L90M		N37S, R41K, L63P, V77I, I93L	B
Brown (2009)	CAS_749_16_33349	CAS_749_16_33349	FJ030789	None	L90M		T12P, K14R, L19I, E35D, N37E, K43R, L63A, A71T, V77I, I93L	B
	CAS_70_1_7172	CAS_70_1_7172	FJ030781	None	L90M		I13V, E35D, L63P, I64V, V77I, L89LR	B
	CAS_111_1_7597	CAS_111_1_7597	FJ030655	None	L90M		L10I, E35D, M36I, N37T, I62V, L63P, T74S	B
Brumme (2009)	G8500	G8500	GQ371902	None	L90M		E35G, M36I, I62V, L63P	B
	H8523	H8523	GQ371926	None	L90M		I62V, L63P, I64M, A71V, P79A	B
	M8528	M8528	GQ372020	None	L90M		L10I, I15V, L19I, M36I, N37E, R57K, D60E, L63P, H69K, I85V	B
Cuevas (2009)	P1209	P1209.1	EU822600	None	L90M		L10I, I15V, E35D, M36I, I62V, L63T, I64V, C67S, I93L	B
	P1626	P1626.1	EU822721	None	L90M		I13V, I15V, I62V, L63S, I64V, V77I	B
	P0036	P0036.1	EU822773	None	L90M		L10I, I15V, E35D, M36I, R57K, L63P, I93L	B
	P0556	P0556.3	EU822776	None	L90M		L10I, I15V, E35D, M36I, I62V, L63T, I64V, C67S, I72IV, I93L	B
Rhee (2009)	CA20997	CA48303	FJ983459	None	L90M		I13V, N37D, I62V, L63P, I64V, C67Y, V77I	B
Smith (2009)	PI11	US2001PI11		None	L90M		K14R, L19I, L63P, A71T, I72V, I93L	B
	PI172	US2004PI172		None	L90M		Q61DE, I62IV, L63APS, I64IL, A71T, V77I, I93IL	B
	PI226	US2005PI226		None	L90M		L10I, T12P, R41K, L63P, I93L	B
	PI229	US2005PI229		None	L90M		L10I, T12P, K14R, R41K, L63P, I93L	B
	PI322	US2002PI322		None	L90M		E35D, M36I, I62V, L63P	B
	CR51	US2007CR51		None	L90M		R57K, L63P, K70KR, V77I	B
	CR119	US2006CR119		None	L90M		Q61E, I62V, L63P, I64L, A71T, V77I, I93IL	B
	CR249	US2006CR249		None	L90M		I15V, K20I, P39T, L63P, A71AITV, V77I, I93IL	B
Vercauteren (2009)	pt2124	552060772	GQ398900	None	L90M		E35D, I62V, L63P, Q92QE, I93IL	B
	pt1871	2032999465	GQ399153	None	L90M		T12P, K14R, L19I, E35D, N37E, K43R, I62V, L63A, A71T, V77I, I93L	B
	pt1372	4x8zRXPiia	GQ399652	None	L90M		L19I, N37S, P39S, I62V, L63P, H69HQ, A71V, V77I, I93L	B
	pt712	8847015175	GQ400312	None	L90M		T12P, K14R, L19I, E35D, N37E, K43R, I62V, L63A, A71T, V77I, I93L	B
	pt617	92J4VmlBq7	GQ400407	None	L90M		L19I, N37S, I62V, L63P, I64M, H69Q, A71V, I93L	B
	pt578	94CzehKRvV	GQ400446	None	L90M		T12P, K14R, L63P, V77I, I93L	B
	pt332	JFbXgs9qR4	GQ400692	None	L90M		L19I, N37NS, I62V, L63P, H69Q, A71V, V77I, I93L	B
	pt79	VPbr4gk1nl	GQ400945	None	L90M		L19I, E34EQ, N37RS, Y59YH, I62V, L63P, H69Q, A71V, V77VI, I93L	B
Wang (2009)	CR0339X	CR0339X	FJ469721	None	L90M		M36I, N37T, R57K, I62V, L63P	B
Bonura (2010)	1080_12	1080_12	GU969498	None	L90M		L10I, N37ND, D60E, I62V, L63P, V77I, I93L	B
	1132_97	1132_97	GU969512	None	L90M		I13V, G16A, K20V, N37D, R57RK, I62IV, I64IL, H69K, K70R, A71V, V77I	B
Ragonnet-Cronin (2010)	PHAC_156	PHAC_156	HM468654	None	L90M	L33I	I13V, K14R, L63P, I93L	B
	PHAC_219	PHAC_219	HM468717	None	L90M		I13V, I15V, K20T, E35G, M36I, N37S, R57K, Q61N, L63P, I64V, T74S, V82I, I93L	B
	PHAC_229	PHAC_229	HM468727	None	L90M		L10I, L19I, E35D, M36I, N37E, L63P, V77VI, I93L	B
	PHAC_370	PHAC_370	HM468868	None	L90M		E35D, N37D, D60E, I62V, L63P, I93L	B
	PHAC_467	PHAC_467	HM468965	None	L90M		E35D, N37D, D60E, I62V, L63P, I93L	B
	PHAC_533	PHAC_533	HM469031	None	L90M		T12TP, D25DN, E35D, M36I, N37D, D60E, Q61D, I62V, L63P, I93L	B
	PHAC_593	PHAC_593	HM469091	None	L90M		K14KR, N37D, R41RK, R57RK, I62V, L63H, A71T, I72V, V77I	B
	PHAC_736	PHAC_736	HM469234	None	L90M	L33I	I13V, L63P, A71V, I72T, I93L	B
	PHAC_845	PHAC_845	HM469343	None	L90M		E35D, M36I, R57K, L63P, I64V, I93L	B
	PHAC_856	PHAC_856	HM469354	None	L90M		T12P, E35D, M36I, N37S, R57K, L63P, I64V, I93L	B
Yebra (2010)	224140	04SP0224140	FJ481755	None	L90M		N37S, I62IV, L63P	B
	243937	05SP0243937	FJ481804	None	L90M		I13V, N37D, R41K, R57RK, D60E, Q61E, I62V, L63P, E65D, A71V, V77I, I93L	B
Chibo (2011)	S178	S178	JF895365	None	L90M		T12P, K14R, L19I, E35D, N37E, K43R, R57K, L63T, A71T, I72V, V77I, I93L	B
Ferreira (2011)	BRMT2358	BRMT2358	HQ638792	None	L90M		L10V, E35D, M36I, N37D, L63P, A71T, I93L	B
Kao (2011)	Pat175	35934	HQ657865	None	L90M		I15V, Q18IL, K20T, N37D, R57K, L63P, A71V, V77I, I93L	B
	Pat123	36329	HQ657917	None	L90M		I15V, Q18L, K20T, N37D, R57K, L63P, A71V, V77I, I93L	B
Truong (2011)	07001508	07001508		None	L90M		L10I, L63D, I64L, A71T, I72K, V77I, I93L	B
	06001138	06001138		None	L90M		I62V, L63P, A71V, I72V, V77I, I93L	B
	06001316	06001316		None	L90M		I13V, Q18I, E35D, N37D, D60E, L63P, I64V, V77I	B
Avila-Rios (2012)	JI00M79LXO	JI00M79LXO	KC169134	None	L90M		T12P, K14R, L63P, V77I, I93L	B
	PEI0M63RXE	PEI0M63RXE	KC169590	None	L90M		L10I, I15V, G16A, E35D, M36I, R41K, I62V, L63P, I64IL, I93L	B
	V2I0MB1RSY	V2I0MB1RSY	KC169717	None	L90M		E35D, M36I, R41K, I62V, L63T, A71V, I93L	B
	D2INM86MSQ	D2INM86MSQ	KC168419	None	L90M		I3A, T12TS, P39S, R57K, I62V, L63P, I64L, A71V, V77I, I93L	B
	B24EM6AFT1	B24EM6AFT1	KC168143	None	L90M		L10I, I13V, I15V, K20I, M36I, R41K, L63P, C67D, A71V, I93L	B
	E15EM95IWL	E15EM95IWL	KC168663	None	L90M		L10I, K14R, I15V, K20T, E35N, M36I, P39T, R41K, I62V, L63P, A71T, I72V, I93L	B
	E2EIM79LXA	E2EIM79LXA	KC168724	None	L90M		L10V, I15V, N37D, R57K, D60E, L63P, A71V, V77I, I93L	B
	E2IQM84NUC	E2IQM84NUC	KC168726	None	L90M		R57K, L63P, I64L, A71V, I72E, V77I, I93L	B
	E2IWMD0OSD	E2IWMD0OSD	KC168727	None	L90M		R57K, L63P, I64L, A71V, V77I, I93L	B
	J1BEM9AISS	J1BEM9AISS	KC169030	None	L90M		L10LI, K20KM, E35D, M36I, R57K, I62V, L63P, A71T, I72V, I93L	B
Ragonnet-Cronin (2012)	A10_146	A10_146	JX014737	None	L90M	L33I	I13V, R41K, L63P, A71V, I93L	B
Ferreira (2013)	BR09SP355	BR09SP355	HM534181	None	L90M		L10I, L19V, L63S, I72V, V77I, I93L	B
Frentz (2013)	EHR-01797	EHR-01797	JX299572	None	L90M		I13V, M36I, N37D, I62IV, L63H, I64L, A71V, I72T, I93L	B
	EHR-45678	EHR-45678	JX300300	None	L90M		I13V, I15V, E35D, M36I, R41K, I62V, L63S, I64L, A71V, I93L	B
	EHR-54354	EHR-54354	JX300445	None	L90M	L33F	L10I, I13V, G16E, K43KR, I62V, L63S, A71T, V75I, I93L	B
	EHR-62467	EHR-62467	JX300582	None	L90M		L10I, T12TI, R41K, D60E, I62V, L63P, I72M, V77I, I93L	B
	EHR-95577	EHR-95577	JX301115	None	L90M		T12P, K14R, L19I, E35D, N37E, K43R, I62V, L63A, A71T, V77I, I93L	B
Hawke (2013)	20959768	20959768	KC238056	None	L90M		L10I, N37S, R41K, L63D, A71T, I72K, V77I, I93L	B
	3594043 H	3594043 H	KC238130	None	L90M	Q58E	L10I, K20I, M36V, N37S, R57K, I62V, L63Q, I64V, T74S	B
	3651991 H	3651991 H	KC238134	None	L90M	Q58QE	L10LI, K20IM, M36V, I62V, L63Q, I64V, T74S, V75VI, F99FL	B
	5496126 H	5496126 H	KC238178	None	L90M	Q58E	L10I, I13IV, K20I, M36V, R41RK, I62V, L63Q, I64V, T74S	B
	5799833 H	5799833 H	KC238186	None	L90M		L33V, L63Q, I64V	B

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