Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	B
Gene	PR
Mutation	L89M
Rx	PI-naive
IncludeMixtures	No

References	109
Patients	338
Isolates	348

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Condra (1996)	pt-J	ptJW0		None		Q18E, L33V, E35D, N37S, L63P, L89M, I93L	B
Hammer (1997)	ACTG320_1132	1132		None		T12I, I62IV, V77I, L89M, I93L	B
	ACTG320_1321	1321		None		L63AT, I72T, V77I, L89M	B
	ACTG320_2348	2348		None		I13V, I15IV, L19LI, I72IV, V77I, L89M	B
Patick (1998)	503-242	503-242B		None		I13V, V77I, L89M	B
Carr (1999)	SE7108	SE7108	AF071473	None		I13V, E35D, M36I, R41K, R57K, H69K, L89M	B
Bacheler (2000)	LB4-P149	P149-0		None		L33V, L89M	B
Caumont (2001)	AC7	AC7	AF326172	None		G16GE, E35D, M36I, R41K, L63C, H69K, L89M	B
Eshleman (2001)	A024	AF357627	AF357627	None		G16E, R41K, I62V, L63R, E65D, L89M	B
Gonzales (2001)	CA4824	CA11885	AY031483	None		T4S, W6W*, I15V, K20R, E35D, M36I, H69Y, L89M, I93L	B
	CA5373	CA13258	AY031928	None		E35ED, N37S, V77I, L89M	B
	CA5627	CA13971	AY032093	None		I13V, L38LI, R41RK, L63P, V77I, V82I, L89M	B
	CA6556	CA16480	AY032462	None		I13V, I15V, K20I, M36I, N37D, L63V, I64M, L89M	B
Perno (2001)	PCF_Pat20	PCF1881	AF376597	None		L10I, I13V, L19I, M36L, N37T, I62V, L63P, L89M, C95F	B
	PCF_Pat116	PCF1624	AF376591	None		I13V, N37T, V77I, L89M	B
	PCF_Pat130	PCF218	AF376523	None		K14R, N37D, E65D, I72V, V77I, L89M	B
	PCF_Pat153	PCF1929	AF376602	None	L33F, Q58E	G16E, N37S, R57K, I62V, L63A, K70R, L89M	B
Servais (2001)	JS8	JS96378	AJ401870	None	V11I, L33F	I13V, K20I, E35D, M36I, N37D, R41K, H69K, L89M	B
	JS10	JS96172	AJ401847	None		L10I, I62V, L63S, C67D, H69K, V77I, L89M	B
Servais (2001)	JS92415	JS92415	AJ279642	None		I13V, L19V, L63P, L89M	B
	JS97510	JS97510	AJ279673	None		I15X, L19T, N37K, R41N, H69K, L89M	B
Dumans (2002)	AD-02	AD-02	AF413831	None		I13V, N37S, R41K, H69Y, V77I, V82I, L89M	B
	AD-05	AD-05	AF413824	None		I13V, E35D, N37S, R41K, H69Y, V77I, V82I, L89M	B
	AD-49	AD-49	AF413861	None		I13V, E35D, N37S, R41K, H69Y, V77I, V82I, L89M	B
	AD-54	AD-54	AF413821	None		I13V, L19I, D60E, L63P, K70E, V77I, L89M	B
Machado (2002)	178	cdpol178	AF373719	None		M36I, L63S, L89M	B
Thomson (2002)	A025	A025	AF408626	None		V11F, I15V, E35D, M36I, R41K, R57K, Q61N, L89M	B
Yang (2002)	DH016	DH016	AB078713	None		T12S, G16E, L19I, E35D, M36I, R41K, L63A, H69Q, L89M, I93L	B
Brindeiro (2003)	BRP2138	BRP2138	AY213435	None		T4S, L5P, Q7Y, L10N, E35D, M36I, R41K, R57K, D60E, Q61N, I62V, L63S, L89M	B
	BRP2148	BRP2148	AY213453	None		L10I, L19I, E35D, K43R, I62V, L63S, I72V, V77I, L89M, I93L	B
	BRP2124	BRP2124	AY213411	None		L10I, T12A, K14R, I15V, G16E, M36I, N37K, R41N, Q61K, L63T, H69K, L89M, I93L	B
	BRP2118	BRP2118	AY213399	None		L19I, N37T, R41K, H69K, V82I, L89M	B
	BRP2137	BRP2137	AY213433	None		E35D, R57K, Q61H, L63V, L89M	B
	BRC1561	BRC1561	AY213549	None		I13V, E35D, M36I, R41K, R57K, Q61D, L63LP, K70Q, V77I, L89M	B
Gittens (2003)	MVG_BB2	MVG_BB2	AY048559	None		N37S, R41K, L63P, V77I, L89M, L90V, I93L	B
	MVG_BB5	MVG_BB5	AY048571	None		K14R, R41K, D60E, L63T, I72V, V77I, L89M, I93L	B
Lan (2003)	NTHvr199	NTHvr199	AY238291	None		I13IV, L19LM, E35D, M36I, N37D, L89M	B
Shafer (2003)	A384_0242	0242a	EF548203	None	L33I	N37S, L63P, L89M, I93L	B
	A384_3092	3092a	EF548287	None		I15V, E35D, M36I, I72V, R87RT, L89M	B
	A384_0800	0800a	EF549072	None		R57RK, V77I, L89M, I93L	B
	A384_4859	4859a	EF549311	None		L10I, K14R, N37C, L63AT, H69Q, V77I, I85V, L89M	B
	A384_0783	0783a	EF549042	None		K14R, E35D, M36MI, R41KN, R57K, L89M	B
Soares (2003)	BRBS470	BRBS470	AF527185	None		I13V, L33V, N37S, L89M, C95S	B
	BRBS535	BRBS535	AF527193	None		L10V, E35D, M36I, R41K, R57K, D60E, Q61D, L89M, C95S	B
	BRP2035	BRP2035	AF527225	None		L10I, M36I, H69K, L89M, I93L	B
	BRP2399	BRP2399	AF527319	None		I13V, N37S, L89M, C95S	B
	BRRJ884	BRRJ884	AF527361	None		L10I, I15V, N37K, R41N, L63I, H69K, T74S, L89M, I93L	B
Eshleman (2004)	ESH_Pat21	ESH471	AY435278	None		I13V, R41K, H69K, L89M	B
Gulick (2004)	RG175	RG175w0		None		L10I, R41K, K45R, L63Q, I64V, V77I, L89M, I93L	B
		RG175w61		None	V11VI	L10IV, M36MI, R41K, K45R, L63Q, I64V, V77I, L89M, I93L	B
	RG295	RG295w0		None		I13V, E35D, R41RK, L63T, H69R, V77I, L89M	B
		RG295w79		None		T12TS, I13V, N37S, R41K, L63T, H69R, V77I, L89M	B
	RG376	RG376w0		None		E35D, R57RK, I62IV, T74S, V77I, L89M	B
	RG501	RG501w0		None		L38I, I62V, L63P, H69Q, L89M	B
Kuritzkes (2004)	KDR_pat239	A0312	AY528129	None		E35D, M36I, L89M, I93L	B
		A0313	AY528130	None		E35D, M36I, L89M, I93L	B
		A0315	AY528132	None		E35D, M36I, L89M, I93L	B
		A0316	AY528133	None		E35D, M36I, L89M, I93L	B
Machado (2004)	N34	N34	AY569870	None		T12P, L19Q, N37S, I64V, V77I, L89M	B
	N39	N39	AY569875	None		L19I, N37S, R41K, I72V, V77I, L89M	B
	N77	N77	AY569902	None		T12S, L33V, M36I, N37S, R41K, R57K, L63P, K70R, V82I, L89M	B
Pariente (2004)	pt5	5	AY315952	None		N37S, V77I, L89M	B
Rhee (2004)	CA14155	CA33252		None		L89M, I93L	B
Bernardin (2005)	PRB959	PRB959-03	AY331296	None		L63P, K70R, V77I, L89M, I93L	B
		PRB959-05	AY331297	None		L63P, K70R, V77I, L89M, I93L	B
Rhee (2005)	AFF143P8	AFFP8W0	AF078580	None		L19I, M36X, L89M, I93L	B
		AFFP8W104		None		K14R, L19I, L89M, I93L	B
	CA9911	CA24476	AY797924	None		I13V, K20X, E35D, M36I, N37D, L63P, L89M	B
	CA14655	CA34066	AY798139	None		T12I, G16E, R41K, I62V, L63IM, I72V, L89M	B
Vazquez de Parga (2005)	RU01035	RU01035	EU345742	None		T12P, L19I, M36L, I62V, L63P, G68D, H69I, L89M, I93L	B
Babic (2006)	DB_SI3942-02	SI3942-02	AJ971124	None		I15V, N37S, I62IV, L63P, L89M, I93L	B
de Sa Filho (2006)	BREPM11871	BREPM11871	DQ085867	None		I15V, E35D, M36I, R41K, R57K, Q61N, I72T, L89M	B
Jayaraman (2006)	4-00-0001	4-00-0001		None		L89M	B
	4-00-0015	4-00-0015		None		L89M	B
Lama (2006)	Pt1562	1562		None		L10I, T12TS, I13IV, M36I, I62V, L63A, E65ED, L89M	B
	Pt3042	3042		None		L10V, I13V, G16E, L63A, V77I, L89M	B
	Pt3092	3092		None		L10V, G16E, E35D, L63H, L89M	B
	Pt3093	3093		None		L10V, G16E, E35D, L63H, L89M	B
	Pt3131	3131		None		L10V, I15V, K20KT, L63P, H69Q, V75I, V77I, L89M	B
	Pt3241	3241		None		L10V, I15V, E35D, H69Q, V77I, L89M	B
	Pt3316	3316		None		I3V, L10V, I13V, G17E, L33V, K45R, L63A, V82I, L89M	B
	Pt3598	3598		None		L10V, T12P, I15V, L19LV, K20KR, M36I, L63T, L89M, I93L	B
	Pt3759	3759		None		I13V, E35D, M36I, R41K, I62V, L63S, I64M, L89M	B
	Pt3784	3784		None		K14KR, I15V, Q18H, I64L, V82I, L89M	B
	Pt3831	3831		None		L10IV, I13V, L19LI, L63T, E65D, V77I, L89M	B
	Pt4055	4055		None		L10V, M36I, I62V, L63A, I64M, L89M	B
	Pt4059	4059		None		L10I, G16E, M36I, P39S, L63LP, I72V, L89M	B
	Pt4071	4071		None		L10I, I15IV, G16E, E35D, L63H, L89M	B
	Pt4234	4234		None		I13V, K20R, M36I, N37D, I62V, L89M, I93L	B
	Pt5005	5005		None		L10V, E35E_TN, M36L, L63A, L89M	B
	Pt5033	5033		None		L10V, I13V, L33V, L63T, I72T, T74A, P79Q, L89M	B
	Pt5060	5060		None		L10V, E35D, L63AV, K70KN, V77I, L89M	B
	Pt5066	5066		None		L10V, K14R, E35D, M36I, N37D, D60E, I62V, L63P, H69Y, L89M	B
	Pt5092	5092		None		L10V, Q18H, L63P, P79D, L89M	B
	Pt5100	5100		None		L10IV, D60E, Q61E, L63P, K70R, I72IV, V77I, L89M, I93L	B
	Pt5143	5143		None		L10I, I13IV, K14KM, I15IV, G16E, E35D, L63H, H69H*QY, I72IT, L89M	B
	Pt5152	5152		None		I3IV, L10IV, E35D, I62IV, L63AV, I64IM, V77I, L89M	B
	Pt5162	5162		None		L10V, T12I, R57RK, L63P, I72T, L89M	B
	Pt5170	5170		None		Q61E, L63P, I64L, L89M, I93L	B
	Pt5195	5195		None	L33F	T12P, I13V, E35D, I62V, L63G, C67CS, L89M	B
	Pt5234	5234		None		L10V, I13V, G17E, K20R, M36I, I62V, L63P, E65D, K70R, I72V, L89M	B
	Pt5603	5603		None		T12P, K14R, E35ED, R41K, Q61E, I62V, L63S, I64M, L89M, I93L	B
	Pt5801	5801		None		T12P, K14R, M36MI, R41K, Q61E, I62V, L63S, I64M, L89M, I93L	B
	Pt6030	6030		None		L10V, K14KR, L19LI, K43R, T74A, L89M	B
	Pt6162	6162		None		L10V, K43R, V77I, L89M	B
	Pt6171	6171		None		L10V, K43R, Q61E, L63P, V77I, L89M	B
	Pt6201	6201		None		L10V, T12S, L63P, I64M, V82VI, L89M	B
	Pt6223	6223		None		L10V, T12A, I13V, K14R, M36I, D60E, Q61E, L63P, K70R, V82I, L89M	B
	Pt6241	6241		None		L10V, L63P, I64M, L89M	B
	Pt6281	6281		None		L10V, M36I, L63P, I64M, L89M	B
	Pt7537	7537		None		L10V, L63V, K70R, I72T, L89M	B
	Pt7846	7846		None		L10V, L19LV, L33V, L63LP, L89M	B
	Pt7848	7848		None		L10V, K14R, I72V, L89M	B
Lindstrom (2006)	SIIDC0220	SIIDC0220		None		I13V, K14R, I15IV, R41K, V77I, L89M	B
	SIIDC0248	SIIDC0248		None		N37CS, R41RK, V77I, L89M, I93L	B
Marechal (2006)	JF_091	JF_091	DQ443687	None		I15V, G16A, K20R, M36I, N37D, I62V, L63T, E65Q, G68D, H69K, L89M, I93L	B
Rodrigues (2006)	BR04RS177	BR04RS177	DQ070575	None		G17E, K45R, D60E, I62V, L63P, V77I, L89M	B
Valle-Bahena (2006)	RT-25	PROT-RT-25	DQ150703	None		K14R, N37K, R57K, V77I, L89M	B
	RT-44	PROT-RT-44	DQ150714	None	L33F	I13V, N37E, R57K, E65D, K70R, V77I, L89M	B
Brumme (2007)	1080	PR_1080	EF368390	None	D30DE	L33V, E35D, N37H, R57K, Q61E, L63P, C67E, V82I, L89M	B
	1344	PRRT_1344	EF368654	None		E35D, I62V, L63P, I72M, L89M, I93L	B
	1790	PRRT_1790	EF369100	None		R41K, L89M	B
Dilernia (2007)	F042	F042	EF120103	None		L10I, I15V, L63T, V77I, L89M, I93L	B
	F111	F111	EF120339	None		L10V, I15V, H69Q, V77I, L89M	B
Gatanaga (2007)	F04-5110-1	F04-5110-1	AB640600	None		L10I, I13V, M36I, L63P, H69Q, L89M	B
Gonsalez (2007)	14	HIV_14	GU288715	None		L63PS, V77I, L89M, I93L	B
	31	HIV_31	GU288709	None		N37S, D60E, I62V, L63T, I72T, V77I, L89M	B
	62	HIV_62	GU288741	None	L33F	P39S, L63LIPT, V77I, I85V, L89M	B
Holguin (2007)	585075	585075	EF583196	None		E35D, L63P, L89M	B
	589769	589769	EF583208	None		P39Q, K45R, D60E, Q61E, L63P, V77I, L89M	B
	613096	613096	EF583262	None		L10LI, N37ND, P39PQ, K45KR, D60E, Q61E, L63P, L89M, I93L	B
	614116	614116	EF583266	None		I13V, I15V, E35D, R41K, R57K, T74A, L89M	B
McGrath (2007)	8	DMG_8		None		L10I, I15V, G16E, E35D, L63H, V77VI, L89M	B
Rios (2007)	CH130	MR_CH130	EF194034	None		L10V, L63P, L89M	B
Sa-Filho (2007)	BREPM1033	BREPM1033	EF637050	None		K14R, I15V, G17D, K20R, M36I, R41K, I62V, L63P, I72V, V77I, L89M, I93L	B
Sanchez Onoro (2007)	589769	589769		None		P39Q, K45R, D60E, Q61E, L63P, V77I, L89M	B
	614116	614116		None		I13V, I15V, E35D, R41K, R57K, T74A, L89M	B
	722213	722213		None		L10I, I13V, K14KR, M36I, L63P, E65D, K70R, L89M	B
Vicenti (2007)	3240	39502R	EF376394	None		L5LV, I13IV, E35D, M36I, D60E, Q61E, I62V, L63P, V77I, L89M, I93IM	B
	5351	73191R	EF376555	None		K14R, G17E, K20M, E35D, M36MI, R41K, R57K, Q61N, L63H, V77I, L89M, I93L	B
Chang (2008)	TW0220a	TW0220a		None		T12S, N37S, L63P, V77I, L89M	B
Ferreira (2008)	53	BR06PR53	EU340741	None		I13V, E35D, I62V, I64M, L89M	B
Holguin (2008)	11339	99SP-11339	DQ926899	None		I13V, K14R, I15L, K20I, M36I, N37D, L63P, H69K, V82I, L89M	B
Holguin (2008)	SP23-350232	SP23-350232	EU255508	None		L10I, I13V, K14KR, I15V, M36I, N37T, R41K, R57K, L63T, C67S, V82I, L89M	B
	SP32-356942	SP32-356942	EU255517	None		T4A, T12N, L19I, N37IT, V77I, L89M	B
	SP18-13077	SP18-13077	EU362921	None		T12S, I13V, L19N, N37S, L63P, H69N, K70R, V77I, L89M	B
	SP10-315669	SP10-315669	EU342794	None		G16A, M36I, N37D, D60E, Q61E, C67V, H69K, L89M, T96TI	B
Ibe (2008)	264	264	AB356279	None		L10LI, T12TA, I13IV, K14KR, I15IV, E35D, M36I, R41K, R57K, Q61N, I64IM, L89M	B
	318	318	AB356319	None		L10IV, I13V, E35D, M36I, K43R, L63P, I72IT, L89M	B
Lloyd (2008)	TX057	03HN_TX057	EU312776	None		E35D, L63LP, L89M	B
McConnell (2008)	NV24	NV24	EU288109	None		M36I, L63P, L89M	B
Miura (2008)	BEC36	BEC36	EU517906	None		G16E, L63T, L89M, Q92K	B
Ndembi (2008)	IAEAM016	IAEAM016	EU306754	None		I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89M	B
Palacios (2008)	12488	12488		None		I13V, N37T, L63S, I64M, L89M	B
	12810	12810		None		I15V, K20M, E35D, M36I, R41K, I62V, L63T, I64M, I72T, T74S, L89M	B
	41056	41056		None		W6F, R8P, G16E, E35D, M36I, I62V, L89M	B
Riddler (2008)	62994	461515Ib		None		I13V, R41K, L63P, L89M	B
	RG84443	RG84443w0		None		I13V, D60E, Q61E, L63P, L89M	B
Sirivichayakul (2008)	NBC-7	NBC-7Pr	JQ364307	None		I13V, I15V, M36V, L89M	B
	NBC-26	NBC-26Pr	JQ364326	None		K14R, I15V, R41K, L63A, V77I, L89M	B
Somi (2008)	KG-05-429	KG-05-429	JQ616977	None		I13V, K14R, K20M, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93IL	B
Aghokeng (2009)	CYV75	CYV75	GU191551	None		I13V, L19P, K20I, E34EQ, M36I, R41K, L63P, H69K, K70KR, L89M	B
	CDL26	CDL26	GU191611	None		L10I, V11A, I13V, I15V, G16E, K20I, E35D, M36I, R41K, I64M, H69K, K70R, L89M	B
	DC036	DC036	GU191636	None		I13V, G17E, K20I, M36I, R41RK, L63S, I64M, H69K, K70KR, L89M	B
	SK_0304	SK_0304	GU191681	None		L10V, T12K, I13V, I15IL, G17E, K20I, M36I, R41K, L63S, H69K, L89M	B
Ayouba (2009)	0.610	0.610-VPR	GQ351826	None		I13V, K14R, I15V, K20I, E35K, M36I, N37D, R41K, H69K, L89M	B
	FD0456	FD0456PI	GQ352066	None		L10V, I13V, E35D, M36I, R41K, H69K, L89M	B
	FD0606	FD0606PI	GQ352085	None		I13V, E35D, M36I, R41K, H69K, L89M	B
Brennan (2009)	A38	ARC-A38	EU711446	None		L33V, N37T, L63H, K70R, L89M	B
Brown (2009)	CAS_362_3_1598	CAS_362_3_1598	FJ030750	None		D60E, I62V, I72V, T74S, V77I, L89M	B
	CAS_544_3_2220	CAS_544_3_2220	FJ030773	None		I13V, D60E, I62V, I72V, T74S, V77I, L89M	B
	CAS_438_3_1871	CAS_438_3_1871	FJ030765	None		D60E, I62V, I72V, T74S, V77I, L89M	B
Brumme (2009)	D3521	D3521	GQ371818	None	V11I	L10V, I13GV, K14I, G16E, K20I, M36I, R41K, G52GR, L63C, H69K, K70R, L89M	B
	L2529	L2529	GQ371981	None		L33V, N37A, R41K, H69Y, I72IV, L89M	B
	N1576	N1576	GQ372029	None		I13V, K14R, G17E, K20I, E35K, M36I, R41K, L63P, H69K, L89M	B
	Q3531	Q3531	GQ372106	None		I13V, K20K*, R41K, L63P, L89M	B
	Q4515	Q4515	GQ372109	None		K14R, I15V, G16A, K20R, M36I, N37D, R41K, D60E, Q61E, I62IV, C67E, H69K, V77I, G86GE, L89M, I93L	B
	R9523	R9523	GQ372143	None		I13V, E35ED, D60E, Q61QE, L63P, L89M	B
	PRRT_4178	PRRT_4178	GQ303867	None		L10V, T12P, N37S, R41K, W42W*, G51GE, L63V, G68GE, R87RK, L89M, I93L	B
Cardoso (2009)	BRGO3011	BRGO3011	FJ548795	None		T12N, K20R, E35D, M36I, R41K, R57K, D60E, Q61E, I62V, L89M	B
	BRGO3013	BRGO3013	FJ548797	None		I15V, L38IM, I62V, L63P, V77I, L89M, I93L	B
Castillo (2009)	27	27PROT	GQ202909	None		K14R, M36I, R57K, L63P, L89M	B
Cuevas (2009)	X2622_2	X2622_2	GU326154	None		I13V, I15V, E35D, L89M	B
	X2697_1	X2697_1	GU326179	None		I13V, N37S, R41K, L63P, E65D, H69K, L89M, I93L	B
Cuevas (2009)	P0976	P0976.1	EU822537	None		I15V, G16E, N37P, P39S, R41K, I62V, L63P, T74S, V77I, L89M, I93L	B
	P1132	P1132.1	EU822580	None		T12S, K14R, E35ED, N37A, V77I, L89M, I93L	B
	P1214	P1214.1	EU822602	None		Q18L, R41K, L63P, I64L, H69K, L89M, I93L	B
	P1408	P1408.1	EU822645	None		T12S, E35D, N37A, V77I, L89M, I93L	B
	P1446	P1446.1	EU822659	None		I13V, N37D, R41K, D60E, Q61N, L63T, I64M, L89M, Q92K	B
	P1563	P1563.1	EU822699	None		T12A, I13V, L19I, N37S, L63P, L89M	B
	P1713	P1713.1	EU822754	None		L10V, N37D, L89M	B
	P1716	P1716.1	EU822757	None		I15V, E35D, M36I, R57K, L63P, L89M	B
	P1748	P1748.1	EU822769	None		I13V, I15V, N37S, P39S, I62V, L63P, V77I, L89M	B
de Sa-Filho (2009)	57635	57635Cub	GQ294606	None		I13IV, G16E, E35D, M36I, N37ND, R41K, K55R, R57K, D60E, Q61D, I72T, L89M	B
	57639	57639Cub	GQ294617	None		L89M	B
	57349	57349Cub	GQ294623	None		I13V, G16E, K20R, E35D, M36I, R41K, K45R, R57K, D60E, Q61D, I72T, L89M	B
Hawkins (2009)	R476	ZZR476	FJ931438	None		L10V, L33V, E35D, R41K, L63P, L89M, I93L	B
Kousiappa (2009)	CY006	CY006	EU673376	None		I15V, K20R, E35D, M36I, R41K, L89M	B
Machado (2009)	A111	BRPA111	GQ200774	None	T74P	I15V, N37S, R41K, L89M	B
Nadai (2009)	109795	109795	EU439718	None		D60E, Q61E, L63H, K70R, L89M	B
	129696	129696	EU839601	None		K14R, M36I, R41K, I62V, L63C, L89M	B
Rhee (2009)	CA18329	CA42805	FJ983457	None		E35D, N37D, R41K, L63P, K70R, L89M, I93L	B
Smith (2009)	PI39	US2001PI39		None		E35D, V77I, L89M	B
	PI46	US2002PI46		None		L10V, T12E, I13V, L33V, N37Y, P39Q, D60E, L63P, L89M	B
	PI64	US2002PI64		None		E35D, V77I, L89M	B
	PI74	US2002PI74		None		E35D, V77I, L89M	B
	PI117	US2001PI117		None		E35D, I62IV, L63LP, T74S, V77I, L89M	B
	PI118	US2000PI118		None		E35D, I62IV, L63LP, T74S, V77I, L89M	B
	PI120	US2000PI120		None		E35D, I62V, T74S, V77I, L89M	B
	PI126	US2001PI126		None		E35D, I62V, T74S, V77I, L89M	B
	PI131	US2000PI131		None		E35D, N37T, R41K, I62IV, L63APT, E65ED, L89M	B
	CR62	US2007CR62		None		I13V, I15V, E35D, N37E, L63P, K70R, I72E, L89M	B
	CR99	US2006CR99		None		I15V, H69Q, L89M	B
	CR234	US2006CR234		None		E35D, I62V, L63LP, T74S, V77I, L89M	B
	CR259	US2006CR259		None		L63P, V77I, L89M, I93L	B
Vercauteren (2009)	pt1926	1726370083	GQ399098	None		I13V, N37S, Q61E, I62V, L63Q, I64M, C67Y, H69K, T74K, V77I, L89M	B
	pt1917	1816895762	GQ399107	None		I13R, E35D, M36I, N37D, I64M, L89M	B
	pt1904	1882156273	GQ399120	None		M36I, N37NT, R41K, I62V, T74A, L89M	B
	pt1831	2331166869	GQ399193	None		I13V, K14R, E35ED, N37D, I64M, I72V, L89M	B
	pt1737	2980766243	GQ399287	None		I13V, I15V, E35D, M36I, N37T, R41K, K45R, L63T, I72V, L89M	B
	pt1504	4240391012	GQ399520	None	V11I	L10M, T12E, I13V, E35D, R57K, L63P, L89M	B
	pt1301	5404184529	GQ399723	None		I13V, L19I, L63S, V77I, L89M	B
	pt1279	5502205538	GQ399745	None		M36MI, L63P, I72T, L89M	B
	pt1230	5812709885	GQ399794	None		L10V, I13V, I15V, M36I, N37S, R41K, L89M	B
	pt1027	7034414849	GQ399997	None		T12I, I15V, G16E, K20KR, E35DN, M36I, P39S, R41K, I62V, L63T, I64L, I72IATV, L89M	B
	pt966	7450959057	GQ400058	None		E35D, K55KR, L89M	B
	pt888	7911033950	GQ400136	None		N37S, R41K, L63HP, H69K, L89M, I93L	B
	pt791	8426162717	GQ400233	None		T4S, I13IV, L33V, N37C, L63C, L89M	B
	pt715	8842627387	GQ400309	None		L33V, N37C, D60E, I62V, L63P, H69T, L89M	B
	pt653	9108056276	GQ400371	None		L33V, N37C, I62V, L63P, H69HN, L89M	B
	pt639	9189285198	GQ400385	None		I13V, E35D, M36I, N37D, I64M, L89M	B
	pt532	9728276635	GQ400492	None		L10V, I13V, G16E, K20R, E35D, M36I, N37T, P39S, R41K, D60E, I62V, C67Y, L89M	B
	pt512	9848994613	GQ400512	None		E35D, M36I, I62V, L63P, L89M	B
	pt430	DpLacaqNS9	GQ400594	None		E35D, M36I, R57K, L63P, L89M	B
	pt336	jachp0IrVU	GQ400688	None		D60E, I62V, I72V, T74S, V77I, L89M	B
	pt317	kdnOnSsSkb	GQ400707	None		I15V, L19IT, E35D, N37S, R41K, Q61E, I62V, V82I, L89M, I93L	B
	pt308	KsUdJC7Ik9	GQ400716	None		I13IV, D60E, I62V, L63LIPT, I72V, T74S, V77I, L89M	B
	pt289	LKmMdtPqRH	GQ400735	None		D60E, I62V, L63P, I72V, T74S, V77I, L89M	B
	pt286	lOphMSEzwJ	GQ400738	None		L63P, I72V, V77I, L89M, I93L	B
	pt134	suS2SKr4KX	GQ400890	None		R41RK, K55KQ, D60E, I62V, L63PT, I72V, T74S, V77I, L89M	B
	pt8	ZPB80QmTIS	GQ401016	None		D60E, I62V, I72V, T74S, V77I, L89M	B
Wallis (2009)	TJC2393700	TJC2393700		None		T12S, K14N, I15V, L19T, K20R, M36I, R41K, Q61D, H69K, L89M, I93L	B
	GT00237954	GT00237954		None		I15V, L19V, E35D, M36I, R41K, K45R, L63P, H69K, V77VI, L89M, I93L	B
	GT00349623	GT00349623		None		K14R, I15V, L19V, M36I, R41K, L63V, H69K, V82I, L89M, I93L	B
Brennan (2010)	Pat111	ARC-A120	JN697268	None		L10I, E35D, R41K, K45R, L63Q, I64V, V77I, L89M, I93L	B
	Pat063	ARC-A175	JN697316	None		L10I, N37S, R41K, L63Q, I64V, V77I, L89M, I93L	B
	Pat035	ARC-A204	JN697344	None		I15V, E35D, M36I, R41K, L89M, Q92K	B
Ndembi (2010)	13025D_P1	13025	GQ409547	None		I13V, R41K, K55R, Y59C, H69Q, L89M	B
Ragonnet-Cronin (2010)	PHAC_308	PHAC_308	HM468806	None		L33V, N37T, L63C, L89M, I93L	B
	PHAC_366	PHAC_366	HM468864	None		Q7QR, T12N, L19I, N37T, P39S, R41K, D60E, L63P, V77I, L89M	B
	PHAC_597	PHAC_597	HM469095	None		M36L, N37S, I62IV, L63C, L89M	B
	PHAC_824	PHAC_824	HM469322	None		I13V, L33V, P39Q, D60E, L63P, L89M	B
Tovanabutra (2010)	KECst_014	14-strain2	FJ623495	None		I13V, K14R, L19I, K20I, E35Q, M36I, R41K, R57K, C67E, H69K, V82I, L89M	B
Yebra (2010)	4369443	07SP4369443	FJ481709	None		I3V, W6S, R8P, R41K, L63S, H69K, K70R, L89M	B
	369443	07SP369443	FJ481712	None		I3V, W6S, R8P, R41K, L63S, H69K, K70R, L89M	B
	176984	04SP176984	FJ481731	None		L33V, N37S, R41K, R57K, L63P, I64L, H69K, L89M, I93L	B
	256081	05SP0256081	FJ481773	None		G16E, E35D, P39Q, K45R, D60E, I62V, L63C, I72V, V77I, L89M	B
	256085	05SP0256085	FJ481777	None		E35D, K43R, R57K, D60E, L63P, A71V, V77I, L89M, I93L	B
	256100	05SP0256100	FJ481796	None		T12TP, I13V, I15IV, M36I, N37E, R57RK, L63V, H69HY, V77VI, L89M	B
	303106	06SP0303106	FJ481844	None		L10V, I15V, E35D, M36I, L89M	B
Carvalho (2011)	O22-83	O22-83	GU214102	None		N37S, R41K, R57K, L89M	B
Chibo (2011)	S194	S194	JF895381	None		E35D, M36I, R57K, L63P, E65ED, H69HR, I72IV, L89M, I93L	B
de Medeiros (2011)	Pat029	RS101	JF487858	None	V32E, I84L	Q7E, E21G, E35N, M36L, N37S, R41K, L89M	B
	Pat035	RS077	JF487864	None		I15V, E35D, N37S, R41K, L63V, H69K, L89M	B
	Pat041	RS118	JF487870	None	I47M	E21K, G27E, N37D, R41K, Q61R, L63P, V77I, L89M	B
	Pat047	RS103	JF487876	None		K14R, I15V, R41K, R57K, H69E, V77E, L89M	B
	Pat073	RS113	JF487902	None	V82G	K20R, E21K, A22T, A28S, D29Y, R41K, R57S, I62V, L63P, I72E, V77I, L89M, I93L	B
	Pat097	RS012	JF487926	None		N37S, R41K, H69K, T74A, V77I, R87K, L89M, I93L	B
Hamers (2011)	CP076300814	CP076300814	HQ994946	None		I13V, K14R, I15V, R41K, H69K, L89M	B
	CP076303108	CP076303108	HQ995284	None		I13V, E35D, M36I, R41K, L89M	B
	CP076300736	CP076300736	HQ995325	None		L10V, T12S, L19K, R41K, H69Y, I72T, V82I, L89M	B
Mezei (2011)	3084	HU3084	JF419419	None		Q18H, L19I, E35D, N37S, L63P, I64ILM, L89M	B
Ng (2011)	HM157	HM157	HQ539181	None		T12P, D60E, L63P, G68E, H69K, L89M, I93L	B
Rolland (2011)	1799	consensus_1799	JF320427	None		I13V, K14R, N37E, Q61E, L63Q, E65D, T74S, V77I, L89M	B
Santos (2011)	J158	J158_PR	JN010547	None		M36I, N37KR, R41N, H69HKNQ, L89M, I93L	B
	J202	J202_PR_RT_CN_RH	JN010611	None		L10V, I15V, E35D, M36I, R41K, R57K, L89M	B
	J265	J265_PR_RT_CN_RH	JN010671	None		L10V, I15V, E35D, M36I, N37E, R41K, K45R, R57K, L89M, I93L	B
Avila-Rios (2012)	JF00FD1OUH	JF00FD1OUH	KC169127	None		L10LV, I13IV, R41K, L63S, I64M, I72V, V77I, L89M, I93L	B
	JV00FG3MTW	JV00FG3MTW	KC169142	None		I13V, L19I, N37S, R41K, K45R, R57K, L63P, I64L, V77I, L89M, I93L	B
	M000M87GT6	M000M87GT6	KC169188	None		I13V, M36I, K43E, R57K, L63P, L89M	B
	M000M95MTE	M000M95MTE	KC169196	None		I13V, I15IV, M36I, L63PS, L89M	B
	CZ00M8_KSK	CZ00M8_KSK	KC168234	None		T12P, N37D, R57K, D60E, L63P, I72V, V77I, L89M, I93L	B
	O000MB9NSS	O000MB9NSS	KC169426	None		T12S, L19V, E35D, N37S, L63P, L89M	B
	D000FDFISX	D000FDFISX	KC168247	None		R57RK, I64ILM, L89M	B
	D000M6BIT9	D000M6BIT9	KC168259	None		I13V, K14R, M36MI, L63P, C67Y, K70X, L89M	B
	VE00M8BDSG	VE00M8BDSG	KC169735	None		L10I, N37T, K45KR, I62V, L63T, I64M, V77I, L89M, I93L	B
	VE00MA9JSH	VE00MA9JSH	KC169736	None		L10I, N37T, K45R, I62V, L63T, V77I, L89M, I93L	B
	VE00MB6JEI	VE00MB6JEI	KC169737	None		L10I, I15IV, N37T, K45KR, I62V, L63T, I64M, V77I, L89M, I93L	B
	E000FB5FT2	E000FB5FT2	KC168502	None		I13V, L19I, K20R, M36I, I62V, L63H, L89M	B
	J000MG1TQL	J000MG1TQL	KC168987	None		M36L, N37S, I62V, L63P, L89M	B
	C100MGGGSP	C100MGGGSP	KC168203	None		T12A, Q61N, I62M, L63T, A71T, L89M, I93L	B
Chow (2012)	11FIR164	11FIR164	JX390610	None		I15V, G16A, D60E, I64L, H69K, L89M, I93L	B
	10MYKJ079	10MYKJ079	JX390611	None		I13V, E35D, M36I, R41K, H69K, L89M	B
	10MYKJ067	10MYKJ067	JX390612	None		K14E, G16E, E35D, M36I, N37D, I62V, E65K, H69K, L89M	B
da Silveira (2012)	BRMS41	BRMS41	JF342294	None		L10V, N37S, P39PS, R41K, K45KR, R57K, L63P, V77I, L89M, I93L	B
De Gascun (2012)	IRL16554	IRL16554	JN622410	None		E35D, N37S, L63P, V77I, L89M, I93L	B
	IRL23295	IRL23295	JN622461	None		T12TS, K14KR, L33V, N37NS, R41RK, L63P, I72V, L89M	B
	IRL49474	IRL49474	JN622604	None		G16E, N37S, I62V, V77I, L89M, I93L	B
	IRL01329	IRL01329	JN622710	None		G16A, N37S, R41RK, I62V, V77I, L89M, I93L	B
	IRL13646	IRL13646	JN622728	None		T12TS, I15V, L19I, E35D, M36I, N37ND, R41RK, I72IV, L89M	B
	IRL34495	IRL34495	JN622763	None		N37S, L63S, V77I, L89M, I93L	B
Delwart (2012)	476-6954-6	476-6954-6	JN214894	None		L33V, M36I, L63P, L89M	B
	478-8950-8	478-8950-8	JN215032	None		E35D, N37S, L63T, V77I, L89M, F99FI	B
	478-9328-6	478-9328-6	JN215180	None		L33V, M36I, L63P, L89M	B
	479-3198-7	479-3198-7	JN215186	None		L10I, E35D, R41K, K45R, L63Q, I64V, V77I, L89M, I93L	B
El Annaz (2012)	14575	14575.PR	JN185271	None		T12P, K14R, E35D, R41K, L63P, L89M, I93L	B
Gaspareto (2012)	CLPG59	CLPG59PT	HM752181	None		L10I, T12I, I13V, G16E, E35D, M36I, R41K, R57K, Q61N, L63S, E65D, I72T, L89M	B
Karlsson (2012)	SE_205	SE_205	JQ698810	None		I15V, L19IT, E35D, N37S, R41K, Q61E, I62V, V82I, L89M, I93L	B
Machado (2012)	CUPL1034	CUPL1034	JN000006	None		I13L, P39S, I64V, L89M	B
	CUPL1035	CUPL1035	JN000007	None	L33I	R41K, L89M	B
	CUPL1036	CUPL1036	JN000008	None	L33I	I3F, I13V, P39S, I62V, L89M	B
	CUPL1075	CUPL1075	JN000047	None		K14R, E35D, R41RK, I64M, L89M	B
	CUPL1102	CUPL1102	JX194181	None	L33I	V11F, D25E, P39S, I62IV, L89M	B
Murillo (2012)	11374	11374	KC412763	None		I13V, I15IV, M36MI, R41K, L63P, I72V, V77I, L89M	B
	11379	11379	KC412765	None		I13V, I15V, R41K, L63P, E65ED, I72IV, V77I, L89M	B
	11406	11406	KC412771	None		L33V, M36I, N37S, R41K, L63P, P81PH, L89M	B
	12013	12013	KC412787	None		I13V, N37D, L63P, V77I, L89M	B
	31024	31024	KC412811	None		L63P, V77I, V82I, L89M, I93L	B
	31174	31174	KC412823	None		L10I, N37Q, R41K, K70R, V77I, L89M, I93L	B
Nazziwa (2012)	5134130	5134130	JX499009	None		L19I, R41K, I62V, L63S, E65D, L89M	B
Ragonnet-Cronin (2012)	A10_187	A10_187	JX014756	None		L10I, I15V, M36L, N37S, L63T, I72T, L89M, I93L	B
	A10_390	A10_390	JX014830	None		L10I, I13V, G16E, E35EK, M36I, N37NDEK, Q61E, L63T, E65D, H69K, I72T, L89M, I93L	B
	F09_439	F09_439	JX015109	None		L10I, I13V, G16E, M36I, L63T, E65D, H69K, L89M, I93L	B
Ragonnet-Cronin (2012)	PHAC09_225	PHAC09_225	JQ675283	None		E35D, N37S, R57K, L63C, I72V, V77I, L89M	B
Yang (2012)	KN-72	KN-72	JQ616935	None	L33F	T12S, I13V, K14N, P39S, Q61H, L89M	B
Alencar (2013)	SP2-0006	SP2-0006	JQ237961	None		I13V, G16E, K20R, M36I, N37S, R41K, R57K, D60E, I62V, L63A, E65D, K70R, L89M	B
	PE2-0029	PE2-0029	JQ238021	None		T12R, I13V, I15IV, E35D, N37E, R57K, L63Y, I64M, C67E, H69R, L89M	B
	RJ2-0053	RJ2-0053	JQ238042	None		T12I, I13V, I15V, G16E, E35D, M36I, P39T, R41K, D60E, I72V, L89M	B
	SP2-0001	SP2-0001	JQ238046	None		K14KR, I15V, G17D, K20R, M36I, R41K, I62V, L63P, I72V, V77I, L89M, I93L	B
	MG2-0024	MG2-0024	JQ238100	None		N37S, L63S, V77I, L89M, I93L	B
	RJ2-0084	RJ2-0084	JQ238178	None		K14R, R41K, H69Q, V77I, L89M	B
Ferreira (2013)	BR09SP85	BR09SP85	HM534068	None		I13V, G16E, N37CS, P39S, K43R, Q61E, I62K, V77I, L89M	B
	BR09SP187	BR09SP187	HM534106	None		T12TA, G16E, E35D, P39S, D60DE, Q61D, L63LI, I72R, V77I, V82I, L89M	B
	BR09SP189	BR09SP189	HM534107	None		I15V, G16E, P39S, Q61D, L63LH, I72T, V77I, L89M, Q92K	B
	BR09SP293	BR09SP293	HM534152	None		I13V, N37S, L63P, H69Q, V77I, L89M	B
Frentz (2013)	EHR-00112	EHR-00112	JX299535	None		L19I, E35D, V82I, L89M	B
	EHR-19349	EHR-19349	JX299862	None		L10I, G16E, E35D, M36I, R41K, L63T, E65D, I72T, L89M, I93IL	B
	EHR-22067	EHR-22067	JX299912	None		L10V, D60E, I62V, L63N, T74K, V77I, L89M, I93L	B
	EHR-27847	EHR-27847	JX300022	None		T12A, K14R, I62V, L63T, I72V, T74S, V77I, L89M	B
	EHR-38722	EHR-38722	JX300192	None		E35D, M36I, R41K, D60E, I62V, L63P, I72V, T74S, V77I, L89M	B
	EHR-57214	EHR-57214	JX300495	None	V11VI	L10IM, I13V, K14R, M36I, L63P, E65D, K70R, L89M	B
	EHR-67300	EHR-67300	JX300670	None		I13V, K14KR, I15V, M36I, R41K, K45R, I62V, L89M	B
	EHR-84742	EHR-84742	JX300974	None		I13V, I62V, L63T, I72V, T74S, V77I, L89M	B
Hawke (2013)	11274405	11274405	KC237888	None		T12P, E35D, M36I, N37ND, L63P, V77I, L89M, I93L	B
	12189532	12189532	KC237906	None		E35D, M36I, K55R, I62V, L63P, L89M, Q92QR	B
	2279067 H	2279067 H	KC238074	None		T12A, K14R, E35D, L63P, L89M, I93L	B
	3579797 H	3579797 H	KC238126	None		N37S, I62V, L63A, V77I, L89M, I93L	B
	3896556 H	3896556 H	KC238143	None		L10I, E35D, L63LFPS, I64ILM, V77VI, L89M, I93L	B

Protease Inhibitors

Database

Resources

Team