Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	B
Gene	PR
Mutation	L89M
Rx	>= 1 PI
IncludeMixtures	No

References	43
Patients	156
Isolates	193

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Condra (1996)	pt-P	ptPW48		IDV	48	M46I, V82F, I84V	L33I	L10I, T12S, I13V, M36I, I64V, L89M	B
	pt-J	ptJW24		IDV	24	I54V, V82F	L33I	L10I, Q18E, K20R, E35D, M36I, N37S, L63P, L89M, I93L	B
		ptJW32		IDV	32	I54V, V82F	L33I	L10I, Q18E, K20R, E35D, M36I, N37S, D60E, L63P, L89M, I93L	B
		ptJW36		IDV	36	I54V, V82F, L90M	L33I	L10I, Q18E, K20R, E35D, M36I, N37S, L63P, L89M, I93L	B
Zhang (1997)	6HeBV	6HeBV71		IDV	71	M46L, I54V, V82A	L24I	L10I, I15V, K20R, M36I, L63P, K70Q, L89M	B
Patick (1998)	503-242	503-242W13		NFV	13	D30N		I13V, V77I, L89M	B
Palmer (1999)	CA1446	CA9848	AY798336	IDV, SQV, NFV	57	M46I, I54IV, V82T, L90M	L10F	M36I, N37D, R57K, L63P, A71V, L89M, I93L	B
Zolopa (1999)	CA1159	CA2635	AF085113	IDV, SQV, RTV	51	M46I, V82A, I84V		L10Y, I15V, D60E, L63P, K70T, T74A, L89M	B
		CA24139	AY798347	IDV, SQV, RTV	256	M46IV, V82T, I84V	T74P	L10Y, I15V, L19LI, K20M, K55N, D60E, L63P, H69R, K70T, L89M	B
Balotta (2000)	CB-264	CB-264	AF252018	SQV, IDV		L90LM		E35D, M36I, R57K, L63LP, H69K, L89M	B
Falloon (2000)	JF03	JF03-(-)4w	AF227691	IDV, SQV	136	M46L, I54V, V82A	L24I	L10I, I15V, K20R, M36I, I62V, L63P, K70Q, L89M	B
		JF03-8w	AF227692	IDV, SQV, APV	144	M46L, I54V, V82A	L24I	L10I, I15V, K20R, M36I, I62V, L63P, K70Q, L89M	B
Walter (2000)	HW6	HW6_2	AF288801	IDV, SQV, NFV	16			I13V, N37S, L63T, E65X, V77I, L89M	B
Brun (2001)	SB-PtE	SB-PtE-BL		SQV, RTV, IDV		I54V, L90M		L10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, I62V, L63H, I64M, K70R, L89M, Q92K	B
Gonzales (2001)	CA1159	CA3148	AY030468	IDV	24			I15V, D60E, L63P, K70T, L89M	B
	CA2099	CA7749	AY030806	IDV, SQV, NFV	99	M46L, I54V, V82A	L10FI, L24LI	I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63C, A71V, L89M, I93L	B
	CA4125	CA9832	AY031114	IDV, SQV, NFV	138	M46I, I54V, V82A	L10F, F53L	L63C, L89M	B
	CA4345	CA10753	AY031208	IDV, NFV, SQV, RTV	148	M46I, G48Q, I54T, V82F, L90M	K43T	L10I, E35D, M36I, N37D, I62V, L63T, I72V, V77I, L89M, I93L	B
	CA4354	CA10762	AY031215	IDV	166	M46I, V82VA, I84IV	L10F, T74TP	V32X, L63PT, I64V, A71AV, L89M	B
	CA4566	CA11217	AY031363	IDV	168	M46I, I54V, V82A	L10F, L33I	N37C, K43KN, K55R, R57K, L63Q, I64V, K70R, I85V, L89M	B
Kempf (2001)	DK-1884	DK-1884		RTV, IDV, SQV, NFV	159			L10I, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63P, H69QK, L89M	B
	DK-3184	DK-3184		RTV, IDV, NFV	185	I54V, V82A	L24I	L10I, I15V, N37D, K45V, L63P, L89M	B
	DK-8284	DK-8284		SQV, IDV, NFV	149	M46I, I84IV, L90LM	T74P	L10I, I13V, L19I, E35D, M36I, R41K, I62V, I64V, H69K, N88Y, L89M	B
	DK-9415	DK-9415		SQV, RTV, IDV	133	I54IV, L90LM		L10LI, I15V, G16GE, K20R, E35D, M36I, R41K, R57K, Q61N, L63LH, I64IM, K70KR, L89M	B
Servais (2001)	JS11	JS99289	AJ401975	IDV	144	M46I, I54V, V82F	Q58E	L10I, I13V, K20R, E35D, M36I, G49V, R57K, Y59E, L63P, H69K, L89M	B
	JS14	JS98060	AJ401920	SQV, RTV, IDV	96	I54V, V82A	Q58E	I15V, K20R, E35D, M36I, N37D, R41K, G51K, K55N, L63Q, H69Y, I85V, L89M	B
		JS98119	AJ401925	SQV, RTV, IDV	112	M46L, I54V, V82A	Q58E	I15V, K20R, E35D, M36I, N37D, R41K, G51K, K55N, L63Q, H69Y, I85V, L89M	B
		JS98231	AJ401937	SQV, RTV, IDV	136	M46L, I54V, V82A	Q58E	I15V, K20R, E35D, M36I, N37D, R41K, G51K, K55N, L63Q, H69Y, I85V, L89M	B
		JS99285	AJ401974	SQV, RTV, IDV	156	M46L, I54V, V82A	L24I, Q58E	L10I, I15V, K20R, E35D, M36I, N37D, R41K, G51K, K55N, L63Q, H69Y, I85V, L89M	B
	JS23	JS99284	AJ401973	SQV, IDV	96	G48GV	L10F, N88T	I15V, K20R, E35D, M36I, R41K, M46X, I62V, L63S, A71V, I72V, L89M, I93L	B
Brindeiro (2002)	TVSP15	TVSP15	AY145821	RTV, NFV	92	V82L	L24I, K43T	L10I, E35D, M36I, R41K, R57K, Q61N, L89M	B
Margot (2002)	MM-206436796	2064367961		PI	NA	V32I, M46I, V82A		L10I, I13V, I15V, R41K, H69Q, I72V, T74S, L89M	B
	MM-371436656	3714366561		PI	NA	M46I, I54V, V82AT		L10I, K14KR, G16E, K20R, E35D, M36I, R41K, K55KR, I62V, L63T, I72V, P79A, L89M, I93L	B
	MM-214336565	2143365651		PI	NA	M46L, V82A	L10F, T74P	I62V, L63P, L89M	B
de Sa Filho (2003)	BREPM138	BREPM138	AY182819	IDV				P9S, I13V, G16E, N37S, V77I, I85IS, L89M	B
	BREPM181	BREPM181	AY182831	IDV				I13V, N37S, A71AV, V77I, L89M	B
Holguin (2003)	SP_LP20	SP_LP20	AF455617	PI	NA			I13V, K20I, M36I, R41K, H69K, A71G, L89M	B
Monno (2003)	ML_Pat10	ML_Pat10		PI	NA			K14R, I15V, E35D, M36I, N37D, L89M	B
Shafer (2003)	A384_0783	0783b	EF549043	NFV	21			K14R, E35D, M36I, R41K, R57K, L89M	B
Wu (2003)	CA1850	CA10733	AF544519	IDV, RTV	136	V32I, M46I, V82A, L90M	F53L	L10I, L63P, I64M, A71V, L89M, I93L	B
	CA4125	CA16200	AF544549	IDV, SQV, NFV	184	M46I, I54V, V82A	L10F, F53L	R41RK, K43KE, L63C, T74S, L89M	B
	CA4354	CA16176	AF544554	IDV, NFV	211	V32I, M46I, V82A	L10F	I3IN, W6WL, L63P, I64V, L89M	B
Colonno (2004)	RC-009-014-023	014-02321		NFV, SQV, ATV	68	M46I, I84V, N88S	L23I	L10I, I13V, E35D, N37Y, R41K, L63X, A71T, V77I, L89M	B
	RC-007-020-517	020-51721		NFV	60	M46I, L90M		I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89M	B
	RC-007-020-432	020-43221		NFV	65	I84C		I13V, K14R, K20I, E35D, R41K, H69K, V82I, L89M	B
	RC-034-040-486	040-4861	AY461499	ATV		I50L		L10V, K14R, M36I, A71AV, L89M	B
Dumans (2004)	RES075	RES075	AY390202	IDV, SQV, NFV, RTV, APV, Unknown	>317	I54IV		L10V, I13V, I15V, K20T, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, L63LP, T74TA, V82I, I85V, L89M, I93IL	B
Gomez-Carrillo (2004)	99055	99055	AY365594	PI	NA			L33V, N37S, L63C, I72V, L89M	B
Gulick (2004)	RG376	RG376w60		ATV	5			E35D, R57RK, I62IV, T74S, V77I, L89M	B
Mueller (2004)	MSM_pat2	MLpat2_a		PI	NA	M46I, I54V, L76V, V82A, L90M	Q58E	L10I, I15V, K20R, M36I, R41K, K55R, R57K, I62V, L63P, A71V, T74KR, L89M, I93M	B
		MLpat2_b		PI	NA	M46I, I54V, V82T, I84V, L90M	Q58E	L10I, I15V, L19I, K20R, M36I, R41K, K55R, I62V, L63T, I64V, I72V, T74K, L89M, I93LM	B
		MLpat2_c		PI	NA	M46I, I54V, V82T, I84V, L90M	Q58E	L10I, I15V, L19I, K20R, M36I, R41K, K55R, I62V, L63T, I64V, I72V, T74K, L89M, I93LM	B
	MSM_pat3	MLpat3_c		PI	NA	M46I, I54V, L76V, V82A, I84V	L33F, K43T	L10V, I13V, N37ND, L63P, L89M	B
Nukoolkarn (2004)	267	267		RTV, IDV		M46I		L63T, I72T, L89M	B
Rhee (2004)	CA14470	CA34189	AY798496	Unknown, IDV, RTV	>47	M46I, I54V, V82A	L33I, K43T, T74TP	Q7R, L10I, K20R, M36I, K55R, I62V, L63X, I64V, I85V, L89M	B
de Sa Filho (2005)	BREPM269	BREPM269	AY771591	PI	NA			K70R, L89M	B
Mo (2005)	9231	9231_d1		PI	NA	I54IV, V82A	Q58QE	L10LI, L19I, K20R, M36I, R41K, Q61DEKN, L63P, H69K, T74S, L89M, I93L	B
		9231_d268		PI, LPV	NA	M46I, I54V, L76LV, V82A	Q58QE	L10I, L19I, K20R, M36I, R41RK, Q61DEKN, L63P, H69K, T74S, L89M, I93L	B
Non-B Workgroup (2005)	TK4010	TK4010		SQV, RTV, NFV	54	L90M		I13V, I15V, K20T, E35D, M36I, R41K, R57K, L63P, H69K, V77I, L89M	B
Rhee (2005)	CA1159	CA7496	AY796533	IDV, SQV, RTV	35	M46I, V82A, I84V		D60E, L63P, K70T, L89M	B
		CA7500	AY796534	IDV, SQV, RTV	39	M46I, V82A, I84V	L10FY	I15V, D60E, L63P, K70T, L89M	B
		CA42689	AY796535	IDV, SQV, RTV, LPV, Unknown	>332	M46I, V82IT, I84V	T74P	L10Y, I15V, L19I, K20R, M36MI, K55N, D60E, L63PST, H69R, K70T, L89M	B
	CA4125	CA34059	AY797022	IDV, SQV, NFV, RTV, APV	319	M46I, I54V, V82A	L10F, F53L	N37D, L63C, T74S, L89M	B
		CA40820	AY798426	IDV, SQV, NFV, RTV, APV	371	M46I, I54V, V82A	L10F, F53L	N37D, L63C, T74S, L89M	B
	CA4345	CA17500	AY797059	IDV, NFV, SQV, RTV	212	M46I, G48Q, I54T, V82F, L90M	K43T	R8RQ, L10I, K20R, E35D, M36I, N37D, R41RK, I62V, L63T, I64M, I72V, V77I, L89M, I93L	B
	SWC-6037	6037-2952		Unknown, IDV	>88	M46I, I84V, L90M		L10I, K20I, E35D, M36I, N37D, L63P, H69Q, A71V, I72V, L89M, Q92R, I93M	B
	SWC-5550	P5550-236		IDV	25			E35D, N37S, K45R, L63P, I72T, L89M	B
		P5550-769		IDV, SQV, NFV	60	I84V, L90M		E35D, M36I, N37S, K45R, L63P, L89M	B
		5550-1850		IDV, SQV, NFV	125	I84V, L90M	L10F	E35D, M36I, N37S, K45R, L63P, I64X, L89M, I93L	B
		5550-2063		IDV, SQV, NFV	137	I84V, L90M	L10F	K20M, E35D, M36I, N37S, K45R, L63P, I64V, L89M, I93X	B
		5550-2777		IDV, SQV, NFV, APV	173	I84V, L90M	L10F	I13IV, K20KM, E35D, M36I, N37S, K45R, Q61QR, L63P, L89M, I93L	B
	CA5373	CA17022	AY797309	NFV	24			N37S, V77I, L89M	B
		CA21377	AY797310	NFV	27			N37S, V77I, L89M	B
		CA33373	AY797311	NFV	27			N37S, R41RK, V77I, L89M	B
		CA37740	AY797312	NFV, LPV	32			N37S, V77I, L89M	B
	CA7101	CA17570	AY797519	SQV, RTV	154	M46L, G48T, I54V, V82A, I84V	L24I	L10I, T12TI, I13V, G16E, K20I, L63T, I72T, T74S, V77I, L89M, T91A	B
		CA33576	AY797520	SQV, RTV	239	M46L, G48T, I54V, V82A, I84V	L24I	L10I, I13V, G16E, K20I, L63T, I72T, T74S, V77I, L89M, T91A	B
		CA37746	AY797521	SQV, RTV	299	M46L, G48T, I54V, V82A, I84V	L24I	L10I, I13V, G16E, K20I, L63T, I72T, T74S, V77I, L89M, T91A	B
	CA7859	CA38104	AY797549	NFV, IDV, APV	331	M46IL, I54M, I84V, L90M	L33F	L10I, I13V, K20T, L63P, A71V, T74S, V77I, L89M, I93L	B
	CA14227	CA33356	AY798014	LPV	12		L33F	I13V, N37S, P39S, L63A, I72IV, V77I, L89M	B
		CA33720	AY798015	LPV	30		L33F	I13V, N37S, P39S, L63A, I72IV, V77I, L89M	B
	CA14470	CA33761	AY798088	Unknown, IDV	>22	M46I, I54V, V82A	L33I, K43T	Q7R, L10I, K20KR, M36I, K55KR, D60DE, I62V, L63LV, I64V, I85V, L89M	B
	CA16426	CA39012	AY798251	PI	NA	M46L, I84V	Q58E	L10Y, R41RK, L63A, T74K, L89M	B
	CA17599	CA41438	AY798266	RTV, IDV, LPV	330	M46L, I54V, L76V, V82A	L23I	L10I, I15V, I62V, L63V, H69R, A71V, I72K, L89M, I93L	B
Baxter (2006)	12-1024	1024-30513	DQ876266	PI, RTV, TPV	>8	M46I, L76LV, V82F, L90LM	L33F, Q58E	L10V, I13V, E35D, M36I, R57K, I62V, L63S, L89M	B
	12-1495	1495-30527	DQ876046	PI	NA	M46L, I54V, V82C, I84V	L24I, V32V_F, T74P	L10I, I13V, K14KR, L19LI, M36L, R41K, K55R, I62V, L63P, L89M	B
	12-1203	1203-30325	DQ876063	PI	NA	M46L, G48V, I54V, V82A	L33F	L10V, I13V, N37HY, R41I, I62V, L63T, T74A, I85V, L89M, T91A	B
	12-1308	1308-30408	DQ876223	PI	NA	M46L, G48V, I54T, V82A	L24LI, L33F, K43T	L10I, I13V, K20R, E35D, M36I, N37D, I62V, L63Q, I72V, T74S, I85V, L89M	B
	12-1020	1020-30317	DQ876258	PI	NA	V32I, M46L, I47V, G48L, I54M, V82A	L24I, L33F, F53L, Q58E	L10V, I13V, L63A, I72EV, T74S, V77I, L89M	B
	12-1019	1019-30317	DQ876260	PI	NA	M46I, V82F, L90LM	L33F, Q58E	L10V, I13V, E35D, M36I, R57K, I62V, L63PS, L89M	B
	12-1678	1678-30331	DQ876270	PI	NA	M46I, I54V, I84V, L90M	L33F, Q58E, N83D	L10I, I13V, M36L, I62V, L63P, I64V, L89M	B
	12-1730	1730-30424	DQ876275	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	L10F, L33F, Q58E	T12A, I13IV, G16A, L19I, E34Q, I62V, L63P, A71L, V77I, L89M, I93L	B
	12-1069	1069-30528	DQ876395	PI	NA	M46I, I54V, L76V, V82A	K43T	L10IV, T12I, I15V, K20R, E35D, M36I, R41K, K55R, D60DE, Q61N, I62IV, L63T, E65D, H69HR, I72T, T74S, L89M	B
	12-2093	2093-30814	DQ876413	PI	NA	M46I, I54V, L76V, V82A	L10F, L24I, L33F	I13V, M36I, I62V, L63P, L89M	B
	12-1931	1931-30508	DQ876426	PI	NA	M46L, I54V, V82A	L24I, F53L	L10V, I15V, K20R, E35D, M36I, N37E, K55R, I62V, L63P, T74S, L89M	B
	12-2107	2107-30626	DQ876434	PI	NA	M46I, I54IL, N88S	L10F, Q58E	I13V, M36MI, N37E, I62IV, L63S, V77I, L89M, I93L	B
	12-1810	1810-30512	DQ876447	PI	NA	I54M, I84V, L90M	L33F, G73T	L10I, I13V, N37D, L63P, C67Y, H69R, K70T, A71V, P79A, L89M	B
	12-1969	1969-30626	DQ876454	PI	NA	D30N, V32I, M46I, I47V, I54L, I84V, L90M	L10F, L33F, F53L, N88D	I13V, E34Q, I62V, L63C, T74E, V77I, P79A, L89M	B
	12-1853	1853-30428	DQ876668	PI	NA	M46I, I54V, I84V	L10F, L24I, F53L	I62IV, L63P, T74S, L89M, T91A	B
	12-1857	1857-30527	DQ876669	PI	NA	I54L, I84V	L33F	L10I, I13V, N37S, I62V, L63A, T74S, V77I, L89M, I93L	B
	12-2150	2150-30818	DQ876682	PI	NA	M46I, I54LV, L76V, V82A	L33F	L10I, I13V, G16E, M36IV, P39P_EK, K43KQ, K55R, D60E, Q61D, L63T, C67Y, I72T, T74TS, L89M	B
	12-1594	1594-30822	DQ876688	PI	NA	M46MI, I54V, I84V, L90M	L10F, Q58E	K20R, E35D, M36I, N37S, R41RK, I62V, L63T, A71V, I72T, T74S, L89M, Q92K, I93L	B
	12-1441	1441-30527	DQ876844	PI	NA	M46L, I54V, V82A	L10F, L24I, L33F, Q58E	E35D, M36I, N37DE, D60E, I62V, L63P, L89M	B
	12-1166	1166-30317	DQ876934	PI	NA	M46I, I54V, L76V, I84V, L90M	L33F	L10I, I13V, K20R, E35D, M36I, N37ND, R41RK, K55KR, D60E, I62IV, L63P, I64V, K70T, A71V, I72T, L89M, I93L	B
	12-1958	1958-30606	DQ876990	PI	NA	I54V, L76V, V82F	L23I, L33I, Q58E	L10I, Q18E, K20KR, E34D, E35D, M36I, N37C, I62V, L63P, H69R, L89M	B
	12-1562	1562-30610	DQ877062	PI	NA	M46I, I54V, L76V, V82A	L10F, L24I, L33F, K43T	T12Q, I13V, L19I, M36MI, K55KR, I62V, L63P, C67E, L89M, T91V	B
	12-1267	1267-30314	DQ877134	PI	NA	G48M, I50V, I54V, V82A	L33F, K43T, F53L, Q58E	L10I, K20R, E35D, M36I, D60E, I62V, L63P, T74S, I85V, L89M	B
	12-3004	3004-30219	DQ877177	PI	NA	M46L, G48V, I54V, V82A, L90M	Q58E	L10I, I15V, L19I, K20R, E35D, M36I, N37D, R57RK, I62V, L63V, I72V, T74S, L89M	B
		3004-30716	DQ876728	PI, RTV, TPV	>21	M46L, I47IV, G48V, I54V, V82A, L90M	Q58E	L10I, I15V, L19I, K20R, E35D, M36I, N37D, I62V, L63V, I72V, T74S, I85IV, L89M	B
	12-3173	3173-30812	DQ877202	PI	NA	M46I, I84V, L90M		L10I, I62IV, L63C, I64V, V77VI, P79ADNT, L89M	B
	12-3034	3034-30306	DQ877214	PI	NA	M46L, V82A	L24I	L10I, K55R, I62V, L63C, T74S, L89M	B
	48-1162	1162-30814	DQ877267	PI	NA	M46L, I54V, L76V, V82A	L23I	L10I, I15V, K20R, E35D, M36I, N37D, R57K, Q61N, L63C, L89M	B
	48-1139	1139-30814	DQ877399	PI	NA	M46L, G48V, I54T, V82A	L24I	L10I, K20R, E35D, M36I, N37DE, R41K, K43R, R57K, Q61N, L63C, T74S, L89M	B
	48-1247	1247-30610	DQ877770	PI	NA	M46I, I54V, L76V	L23I, L24I, F53L, Q58E	L10I, T12P, L19LI, N37S, I62V, L63Q, I64V, H69R, A71V, V77I, L89M, I93L	B
	48-1270	1270-30923	DQ877791	PI	NA	M46I, I84V, L90M	Q58E	L10V, L63P, I66V, H69R, I72IT, T74K, L89M, Q92K, I93M, C95F	B
	48-2013	2013-30324	DQ877845	PI	NA	M46L, I54V, V82A	L24I, Q58QE	L10V, I15V, K20R, E35D, M36I, I62V, L63T, I72T, T74A, L89M	B
	48-2233	2233-30929	DQ877874	PI	NA			I13V, K14R, K20I, E35D, M36I, R41K, H69K, V82I, L89M	B
	48-3012	3012-30305	DQ877922	PI	NA	V32I, M46I, I47V, I54M, V82A, L90M	L10F, K43T, F53LW	M36A, P39T, I62V, L63P, I64V, A71IV, V77VI, L89M, I93L	B
	48-3018	3018-30725	DQ877928	PI	NA	G48V, I50V, I54A, V82A	K43T	L10I, I13V, G16E, K20I, E35D, M36I, N37E, D60N, I62V, L63T, I72T, T74A, L89M	B
	48-3059	3059-30401	DQ877971	PI	NA	M46L, V82A, I84V	V11I, L24I, L33F	L10I, I13V, K20R, E35D, M36I, N37E, I62V, L63PT, E65ED, T74S, I85IV, L89M	B
	48-3099	3099-30721	DQ878006	PI	NA	M46I, I54V, L76V, I84V, L90M	L10F, Q58E	I13V, I15V, L19I, K20IT, E34Q, E35D, M36I, N37K, R57K, L63P, I64V, L89M	B
	48-3139	3139-30414	DQ878050	PI	NA	V32I, I47V, I54M, I84V	L10FI, L33F, M46V, Q58E	I13V, K14R, I15V, E34Q, I62V, L63P, I72M, G73V, L89M, I93L	B
	48-3165	3165-30507	DQ878074	PI	NA	M46L, I54V, L76V, V82A, L90M	L33F, K43T	L10I, I13V, K20R, E35D, M36I, K55R, R57RK, D60E, I62V, L63P, A71V, L89M, I93L	B
	48-3189	3189-30506	DQ878097	PI	NA	M46I, I54V, L76V, V82A, L90M	K43T	L10V, I15V, N37D, K55R, R57K, D60E, I62V, L63P, H69R, A71V, L89M, I93L	B
		3189-40401	DQ878098	PI, RTV, TPV	>47	M46I, I47V, I54M, L76V, V82A, L90M	K43T	L10V, I15V, N37D, K55R, R57K, D60E, I62V, L63P, H69R, A71V, L89M, I93L	B
		3189-40604	DQ878099	PI, RTV, TPV	>56	M46I, I47V, I54M, L76V, V82AT, L90M	K43T	L10V, I15V, N37D, K55R, R57K, D60E, I62V, L63P, H69R, A71V, L89M, I93L	B
	48-3225	3225-30521	DQ878132	PI	NA	M46L, I54V, V82A, L90M	L23I, L33F, K43T, F53L, T74P	L10I, I13V, L19I, K20R, E35D, M36I, N37T, K55R, I62V, L63T, C67E, I72T, L89M	B
	48-3239	3239-30521	DQ878146	PI	NA	M46I, L76V, I84V, L90M	L10F, L33F, Q58E	I13V, K20R, E35D, M36I, N37DE, R57RK, I62V, L63Q, I64V, L89M	B
	48-3282	3282-30916	DQ878189	PI	NA	M46L, I54V, V82AT	L10F, L24I	I15V, K20R, E35D, M36I, R41K, K55R, R57K, I62V, L63Q, I64V, A71V, L89M	B
	48-3292	3292-30924	DQ878197	PI	NA	M46I, I47A, I84V	F53L	L10I, I13V, K20M, E34Q, N37D, L63P, I64V, V77I, L89M	B
	48-3294	3294-30729	DQ878199	PI	NA	M46L, I54V, L76V, V82F, L90M	L23I, L33F, Q58E	L10I, I13V, K14KR, D60DN, Q61QH, L63P, C67DE, A71AV, V77I, L89M, I93L	B
	48-3320	3320-30829	DQ878219	PI	NA	M46I, I54V, L76V, V82M, L90M	L33I, Q58E	L10V, K20R, E35D, M36I, N37D, K55R, R57K, Q61QE, I62V, L63P, K70T, A71V, L89M, I93L	B
		3320-30917	DQ878220	PI, RTV, TPV	>3	M46I, I54V, L76V, V82M, L90M	L33I, Q58E	L10V, K20R, E35D, M36I, N37D, K55R, R57K, Q61QE, I62V, L63P, K70T, A71V, L89M, I93L	B
	48-4009	4009-40802	DQ878244	PI, RTV, TPV	>68	M46I, I47V, I54V, V82T	L33F, K43T	L10I, I13V, I15V, E34Q, E35D, M36L, R41RK, G51A, K55R, I62V, L63P, A71V, V77I, L89M	B
	48-4011	4011-30331	DQ878247	PI	NA	M46I, I54V, V82A, I84V	L24I, Q58E	L10I, I15V, K20R, M36I, L63P, T74K, L89M, T91S	B
	48-4052	4052-30218	DQ878285	PI	NA	I54V, V82A	L24I, L33F	L10I, G16E, K20R, M36I, N37D, K45V, R57K, I62V, L63R, C67Y, K70T, L89M	B
	48-4078	4078-30225	DQ878307	PI	NA	M46L, I54L, V82F, I84V, L90M	L23I, L33F	L10V, I13V, L19V, E35D, M36L, N37D, F53FY, Q61QE, I62V, T74E, L89M	B
	48-4121	4121-30407	DQ878352	PI	NA	M46I, I54V, V82ST, I84V	L24I, L33F	L10I, T12P, I13IV, L63P, A71I, L89M, Q92R, I93L	B
	48-4206	4206-30415	DQ878439	PI	NA	M46L, I54V, V82A, I84V	L10F, L24I, L33F	I13V, G16GA, I62V, L63P, T74S, L89M	B
	48-4232	4232-30428	DQ878464	PI	NA	M46L, I54V, V82A	L24I, Q58QE	L10I, I15V, K20R, E35D, M36I, N37E, R57RK, I62V, L63P, L89M, Q92K	B
	48-4249	4249-30721	DQ878482	PI	NA	M46L, I54V, V82A	K43T, T74P	L10V, I13V, I15V, L19V, K20M, E35D, M36I, N37NK, R41K, I62V, L63Q, I64V, L89M	B
	48-4392	4392-30722	DQ878532	PI	NA	M46I, L76V, V82A, L90M	V32A, L33F, Q58E	L10V, I13V, G16A, K20R, E35D, M36I, N37E, K55R, D60E, Q61E, I62V, L63P, A71V, L89M, I93L	B
	48-5017	5017-30530	DQ878552	PI	NA	M46I, I54V, L76V, I84V	Q58E	L10I, T12P, K20KR, E35D, M36I, R57K, D60E, I62V, L63P, A71V, V82I, L89M, I93L	B
	48-6038	6038-30428	DQ878637	PI	NA	M46MI, G48AV, I54V, L76V, V82S	L24I, L33F, F53FL, Q58E	L10I, I13V, G16E, R41RK, K55R, L63C, V77I, L89M	B
	48-6048	6048-30515	DQ878647	PI	NA	M46IV, I54V, V82A, L90M	F53L	L10Y, I13V, K20I, E35D, M36I, N37D, R41K, K55R, D60E, Q61E, I62V, L63P, I64V, E65EQ, T74TA, L89M	B
	48-6071	6071-30604	DQ878669	PI	NA	M46I, L76V, V82F, L90M	L23I, L33F	L10I, T12K, I13V, K14KR, I62V, L63P, T74A, V77I, L89M	B
	48-6088	6088-30603	DQ878683	PI	NA	M46I, I54V, L76V, V82F, I84V, L90M	L23I, L33F, G48E, Q58E	L10I, I13V, E34K, N37T, I62V, L63P, V77I, L89M	B
	48-6249	6249-30929	DQ878808	PI	NA	V32I, M46I, I47V, I54M, V82A	L10FV, L33LF, K43T	I15V, G16E, K20M, E34EQ, M36V, I62IMV, L63T, I72T, T74A, L89M	B
	48-6265	6265-30806	DQ878822	PI	NA	I54V, V82F	L33F, Q58E	L10IV, E35D, M36I, N37S, R41K, R57K, Q61E, I62V, L63P, L89M	B
	48-6304	6304-30910	DQ878843	PI	NA	M46I, I47A, I84V		L10V, I13V, I15V, G16GE, K20I, R41K, H69K, T74A, V77I, L89M	B
	48-6371	6371-30930	DQ878881	PI	NA	M46I, I50L, L90M	K43T	T12S, K20M, E34EA, E35EG, M36I, I62V, L63P, I64V, L89M, I93L	B
	48-7105	7105-30910	DQ878959	PI	NA	M46I, I50V, I54V, V82C	V11VI, L33F, Q58E	L10I, K20R, E35D, M36I, K55R, D60E, I62V, L63P, I64L, A71V, I85V, L89M	B
	48-7181	7181-30904	DQ879017	PI	NA	M46L, V82A, I84V	L24I, L33F	L10I, T12P, I13V, K14R, L63P, I66V, T74S, V77VI, L89M, I93L	B
	48-9324	9324-30929	DQ877304	PI	NA	I54V, V82A		L10V, K14EQ, I15V, L19IT, K20R, E35D, M36I, R41K, R57K, Q61N, L63V, E65D, H69Y, I72T, L89M	B
	48-9205	9205-30917	DQ877486	PI	NA	M46I, I54V, L76V, V82A		L10I, I13V, G16E, L19I, L63T, H69K, T74A, L89M	B
	48-9028	9028-30825	DQ877497	PI	NA	M46I, I47V, I54V, V82F	Q58E	L10I, K20I, E35N, M36I, N37D, I62V, L63T, I72T, V77I, I85V, L89M	B
	48-9273	9273-30918	DQ877521	PI	NA	M46I, G48V, I50V, I54T, V82A, L90M	L33F, K43T	L10IV, K20R, E34N, E35D, M36I, N37NS, R41K, Q61EG, I62V, L63ADHP, I64IL, A71V, I72IT, T74S, L89M, I93L	B
	48-9182	9182-30901	DQ877535	PI	NA	M46I, I54A, I84V, L90M	L10F, L33F, Q58E, T74P	T12K, I13V, I15V, K20T, E35G, M36L, R41K, I62V, L63Q, I64V, A71V, L89M, I93L	B
	48-9248	9248-30922	DQ877547	PI	NA			I15V, D29DV, E35D, M36I, R41K, K45KR, R57RK, Q61DN, L63HP, L89M	B
	48-9334	9334-30929	DQ877553	PI	NA			E35D, N37S, V77VI, L89M	B
	48-9308	9308-30918	DQ877567	PI	NA	M46I, I54V, V82A, L90M	Q58E	L10I, T12E, I15V, K20R, M36I, N37NDEK, R41RK, K55R, R57K, D60E, Q61N, L63P, L89M, I93L	B
	48-9375	9375-30929	DQ877684	PI	NA	L90M		L10V, I13V, Q18L, E35D, M36I, R41K, R57K, Q61N, I62V, T74S, V77I, L89M	B
	48-9120	9120-30925	DQ877707	PI	NA			L10LV, I15V, K20KT, E35DN, M36I, R41K, R57K, D60E, Q61D, L89M	B
	48-9129	9129-30918	DQ877727	PI	NA	M46L, I54V, V82A, L90M	K43KT	R8RG, L10IV, L19I, K20R, E35D, M36I, R41K, K55KR, R57K, D60E, Q61N, I62V, L63P, E65D, I72V, L89M	B
	48-9044	9044-30925	DQ877737	PI	NA	M46I, I54IV, V82F, I84V	L33F, T74P	L10I, I15V, G16E, Q18R, L19P, K20L, N37S, I62IV, V77VI, I85V, L89M	B
	48-8033	8033-30514	DQ879071	PI	NA	M46I, I50V, I54V, V82A	Q58QE	L10I, I13IV, I15V, K20R, E35D, M36I, R41K, D60E, L63P, L89M, I93L	B
Lama (2006)	Pt3130	3130		PI	NA	M46MI, L90M		L10V, L63P, H69Q, V77I, L89M, Q92QK, I93IL	B
Rhee (2006)	CA1850	CA63813		IDV, RTV, APV, FPV	472	V32I, M46I, I54M, V82A, L90M	L33F, K43T	L10I, D60E, L63P, I64M, A71V, L89M, I93L	B
Sanabani (2006)	02BR006	02BR006	DQ358807	PI	NA	I54V, V82F, L90M		L10I, L19V, E35D, M36I, L63P, L89M, I93L	B
Santos (2006)	098	098PR_RT	AY275758	LPV	13	I54V, V82T, L90M		L10I, I15V, L19I, K20R, M36I, N37D, K45R, R57K, L63P, A71V, I85V, L89M, I93L	B
Eyer-Silva (2007)	BRSQ06	04BRSQ06	EF042630	LPV			L33F	L10I, I13V, L63I, V77I, L89M	B
McGrath (2007)	8	DMG_8a		ATV	48	I50L, N88NS	L33LF	L10I, I15V, G16E, K20KIT, L23LP, E35D, M36MV, L63H, A71AV, V77VI, L89M	B
Riddler (2008)	RG84443	RG84443w12		LPV	12			I13V, E35ED, D60E, Q61E, L63P, L89M	B
Cardoso (2009)	3064	BRGO3064	FJ638433	PI	NA			T12A, I15V, L19I, E35D, M36I, I62V, L63T, I72V, V77I, V82I, L89M	B
	3096	BRGO3096	FJ638443	PI	NA			R57K, L63P, V77I, L89M	B
	3115	BRGO3115	FJ638453	PI	NA	M46I, I54V, L76V, V82A	L24I, Q58E	L10I, T12P, I15V, G16E, K20M, E35D, M36I, N37NK, Q61D, L63C, L89M	B
Rhee (2009)	CA1850	CA50800	FJ983150	IDV, RTV, APV	416	V32I, M46I, I54M, V82A, L90M	L33F, K43T	L10I, D60E, L63P, I64M, A71V, L89M, I93L	B
	CA7889	CA20332	FJ983241	IDV, NFV, SQV, RTV, APV	183	M46I, I84V	L10F, L33F, F53L, T74P	L63T, L89M	B
Dau (2010)	08472A	08472A	GU581915	PI	NA	I54IV		L10V, I15V, E35D, M36I, I62V, L63A, L89M	B
	12739A	12739A	GU582064	PI	NA			L10I, R41K, I62IV, L63S, E65D, I72T, V77I, V82VI, L89M, I93L	B
Rhee (2010)	CA17599	CA64053	GQ211895	RTV, IDV, LPV, APV, Unknown	>415	M46L, I54V, L76V, V82A	L23I, F53L	L10I, I15V, I62V, L63V, H69R, A71V, I72K, L89M, I93L	B
Jones (2012)	133405	133405	JN669522	PI	NA		L33I	I13V, K14KN, I15IV, L19V, M36I, N37D, D60E, L63P, L89M, Q92K	B
	147705	147705	JN669697	PI	NA	M46L, I54V, V82A, L90M	F53FL	L10I, K20R, E35D, M36I, N37ND, R41K, R57K, Q61N, L63A, A71V, L89M, I93L	B
	157536	157536	JN669889	PI	NA			L63P, L89M	B
	157544	157544	JN669891	PI	NA	M46L, V82A	L24I	L10I, T12P, K14R, I15V, G16E, N37D, R41R_R, I62V, L63H, T74S, L89M	B
	166819	166819	JN670135	PI	NA	M46L, I54L, I84V	L24I, K43T, T74P	L10I, T12P, I15V, G16E, K20R, E35D, M36I, I62V, L63H, I72V, L89M	B
	168160	168160	JN670171	PI	NA			P1PS, L10V, T12I, I13V, A22AT, L63P, V77I, L89M	B
	173392	173392	JN670326	PI	NA	L90M	Q58E	L10LV, T12PQ, I13IV, L19LI, K20IR, E35D, M36I, N37NT, I62V, L63P, I64V, A71T, V82VI, L89M, Q92K, I93L	B
	179865	179865	JN670529	PI	NA	M46L, G48S, I54V, V82A, L90M	F53L	L10I, G17GE, K20R, E35D, M36I, N37D, R41K, R57K, Q61DN, L63A, A71V, T74S, L89M, I93L	B
	185252	185252	JN670699	PI	NA	I54V, V82C	L33F	T12K, I13V, K14N, G16A, Q18H, L19I, K20KR, M36I, I62IV, L63C, I72IV, T74A, L89M	B
	193454	193454	JN670900	PI	NA	I54V, L76V, V82A		L10I, T12P, K20R, M36I, R41K, I62IV, L63P, A71V, L89M, I93L	B
	197471	197471	JN671074	PI	NA	M46I, I84V	L10F, F53L, T74P	I13V, G16E, L19I, K20T, E35D, M36I, P39Q, K55R, R57K, D60E, Q61N, L63T, I64IV, E65D, L89M	B
	199398	199398	JN671166	PI	NA			N37A, L63P, V77I, L89M, I93L	B

Protease Inhibitors

Database

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