Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	L89I
Rx	>= 1 PI
IncludeMixtures	No

References	19
Patients	57
Isolates	65

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Cabana (1999)	Cab-b	B41	AF102281	IDV	40	M46I, L76V, V82A, I84V		L10I, I13V, Q18H, L63P, L89I	B
		B44	AF102282	IDV, SQV, RTV	74	L76V		L10I, I13V, L63P, L89I	B
		B47	AF102283	IDV, SQV, RTV	122	M46I, L76V, V82A		L10I, I13V, Q18H, I62V, L63P, L89I	B
		B58	AF102284	IDV, SQV, RTV	136	M46I, L76V, I84V		L10I, I13V, K14R, L63P, L89I	B
Brun (2001)	SB-PtE	SB-PtE-w16		SQV, RTV, IDV, LPV	16	I54V, V82A, L90M		L10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61D, A71V, I72R, L89I, Q92K	B
Gonzales (2001)	CA3871	CA9643	AY030878	SQV, IDV	158	I54A, V82F		L10I, I13V, K14R, I15V, K20M, M36V, N37T, I62V, I64V, A71V, L89I	B
	CA4118	CA9810	AY031108	NFV	39	D30N		E35D, M36I, R57K, L63P, L89I, I93L	B
Kempf (2001)	DK-3604	DK-3604		SQV	80	I84V, L90M	F53L	L10I, N37NS, L63P, A71V, L89I	B
	DK-9415	6367_d112		SQV, RTV, IDV, LPV	149	I54AV, V82A, L90M		L10LI, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61D, A71V, I72R, L89I, Q92K	B
		6367_d140		SQV, RTV, IDV, LPV	153	I54A, V82A, L90M		L10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61D, A71V, I72R, L89I, Q92K	B
		6367_d168		SQV, RTV, IDV, LPV	157	I54A, V82A, L90M		L10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61D, A71V, I72R, L89I, Q92K	B
		6367_d427		SQV, RTV, IDV, LPV	194	M46I, I50V, I54V, V82A, L90M		L10V, I15V, G16E, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I64IL, A71V, I72R, L89I, Q92K	B
Brindeiro (2002)	TVGG38	TVGG38	AY145801	RTV, IDV, Unknown, NFV	>66	M46L, I54V, V82A	L10F, I50F	I15V, L63P, L89I	B
Tural (2002)	881506	881506		RTV, IDV	152	M46I, L76V		L10V, I13V, I15V, K20T, R41K, L63P, I64V, L89I	B
Monno (2003)	ML_Pat59	ML_Pat59		PI	NA	D30N	L10F, N88D	I13V, K20R, E35D, M36I, I62V, L63P, I64L, T74S, L89I	B
Saah (2003)	AS-41	AS-41		NFV	68	L90M		I15V, K20T, M36I, D60E, I62V, T74A, L89I	B
Shafer (2003)	A384_0901	0901d		NFV, RTV, APV	160	I54L, I84V, L90M	L33F, N83D	L10I, K20R, E35N, M36L, N37D, I62V, L63P, A71V, L89I	B
Wu (2003)	CA3871	CA11039	AF544533	SQV, IDV	177	I54A, V82F		L10I, I13V, K14R, I15V, K20M, M36V, N37T, I62V, I64V, A71V, L89I	B
	CA6800	CA21370	AF544598	SQV, RTV, APV, IDV, LPV	221	M46L, I84V	L33F, N83D	T4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89I	B
Colonno (2004)	RC-008-039-230	039-23021		NFV	79	D30N	L10F, N88D	T12S, L19Q, K20R, L63P, V77I, L89I	B
Mueller (2004)	MSM_pat5	MLpat5_c		PI	NA	M46IT, I50V, I54V, L76V	L10F	T4S, L63P, H69Q, A71V, L89I	B
Garcia-Bujalance (2005)	GBS_04	GBS_04	AY872285	RTV, NFV	135	M46L	L23I	I13V, I15V, K20T, M36I, L63P, H69K, A71T, L89I, Q92R	B
Rhee (2005)	CA4345	CA23508	AY797060	IDV, NFV, SQV, RTV, LPV	277	M46I, G48Q, I54T, V82F, L90M	L33F, K43T	L10I, K20R, E35D, M36I, N37D, R41K, Q61QE, I62V, L63T, I72V, V77I, L89I, I93L	B
	CA6800	CA21302	AY797446	SQV, RTV, APV, IDV, LPV	217	M46L, I84V	L33F, N83D	T4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89I	B
Weber (2005)	M62717	M62717	AY677383	IDV, SQV, RTV, LPV	142	I54V, I84V, L90M		I13AV, K14R, I15IV, K20IV, L24X, E35D, M36I, N37D, R41K, K45V, L63LP, I64IV, H69K, V82I, L89I, Q92QK	B
Baxter (2006)	12-1001	1001-30227	DQ875949	PI	NA	G48GASW, I54T, V82A	L33F	L10I, V11L, G16A, L19V, K20R, E34Q, E35D, M36I, N37E, D60E, L63P, I64IL, A71V, V77I, L89I, I93L	B
	12-1243	1243-30312	DQ876074	PI	NA	M46I, I54M, L76V, V82T, L90M	V11I	L10I, T12IV, I15V, G16E, L19P, K20I, M36I, N37S, R41K_K, K55R, R57K, I62V, L63R, K70I, A71V, I85V, L89I	B
	12-1249	1249-30304	DQ876080	PI	NA	M46L, I54L, V82A, L90M	L10F, L33F, K43T	I13V, L24F, K55R, I62V, L63P, A71V, V77I, L89I, I93L	B
	12-1003	1003-30303	DQ876195	PI	NA	M46I, V82F, I84V, L90M	Q58E	L10I, I13V, I15V, K20I, D25DH, E35D, M36I, N37D, L63P, L89I	B
	12-1774	1774-30708	DQ876205	PI	NA	G48V, I54V, V82A, I84V	V11I, L24I, K43T	L10I, T12P, I13V, K20I, M36I, D60E, L63P, I64V, C67Y, L89I	B
	12-2399	2399-30818	DQ876221	PI	NA	V32I, M46I, I47V, I54L, I84V, L90M	L10FY	I15V, G16A, K20V, E34Q, L63Q, I64V, H69Q, T74S, V77I, I85V, L89I, T91S, Q92K	B
	12-2151	2151-30623	DQ876318	PI	NA	M46L, I54A, V82A	L10F, K43KT	I13V, Q18H, K20M, M36I, N37D, R41K, I62V, L63P, I64V, T74S, L89I	B
	12-2214	2214-30722	DQ876457	PI	NA	M46L, I54V, V82VA, I84IV, L90M	L10F	I13V, K20I, L24*, E35D, M36I, I62V, L63C, I64V, T74S, L89I, T91S	B
	12-3053	3053-30402	DQ876723	PI	NA	M46I, I54A, V82A, L90M		L10I, I13V, K20I, L33L_L, E35D, M36I, N37D, I62V, L63P, A71V, L89I	B
	12-2202	2202-30717	DQ876901	PI	NA	M46I, I54V, I84V, L90M	L10F, T74P	I13V, L33M, K55R, R57K, I62V, L63P, C67CY, L89I, T91S	B
	12-1190	1190-30310	DQ876965	PI	NA	V32I, I47V, I54M, I84V, L90M	L10F, L33F	I13V, L19IT, K20R, E34A, E35D, M36I, K43Q, I62IV, L63P, A71I, P79S, L89I	B
	12-2014	2014-30619	DQ877078	PI	NA	M46L, I54V, L76V, V82A, L90M		L10V, T12P, I15V, G16A, L19P, K20M, N37D, R41RK, I62V, L63P, A71V, I72T, L89I, Q92K	B
	12-2149	2149-30813	DQ877081	PI	NA	M46L, I54V, V82A, L90M	L10F, V11I	I13V, K20I, M36I, N37S, R41K, I62V, L63P, A71I, I72L, L89I, T91M	B
	12-3021	3021-30303	DQ877232	PI	NA	M46I, I54V, I84V, L90M	L10F	I13V, I15V, K20T, E35D, M36I, I72V, L89I	B
	48-1168	1168-30911	DQ877356	PI	NA	I54V, V82A, I84V	F53L	L10V, T12E, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, A71V, T74S, I85V, L89I	B
	48-2227	2227-30430	DQ877869	PI	NA	I54V, I84V, L90M		L10LI, I13AV, K14R, K20IV, A22AV, E35D, M36I, N37D, R41K, K45V, L63LP, I64IV, I66IV, H69K, A71AT, V82I, L89I, Q92K	B
	48-3138	3138-30416	DQ878049	PI	NA	M46I, I54V, L76V, V82A	K43T, Q58E	L10V, I13V, K14R, G16E, K55R, R57RK, Q61H, L63H, K70E, L89I	B
	48-3159	3159-30402	DQ878068	PI	NA	I50V, I54V, V82A	L10F, F53L	K14R, I15V, L19P, K20I, E35N, M36I, N37D, R41T, K45V, I62V, I64V, A71V, I85V, L89I	B
	48-3255	3255-30625	DQ878159	PI	NA	I54S, V82M, L90M	L33F	L10V, I13V, I15V, K20R, E34EV, E35D, M36I, N37S, R41K, K55N, L63PT, A71V, V77VI, L89I, I93L	B
	48-4098	4098-30521	DQ878328	PI	NA	V32I, M46L, I54V, V82A, L90M		T4TP, L10V, K14R, I15V, L19Q, K20R, M36I, L63P, A71V, L89I, Q92K	B
	48-4104	4104-30224	DQ878334	PI	NA	M46I, I54V, V82A, I84V, L90M	L33F, F53FL, Q58E	T4S, L10I, V11L, I13V, G16E, L19I, M36I, Q61R, L63T, L89I, T91S	B
	48-5012	5012-30509	DQ878547	PI	NA	I54V, V82A, L90M	L33F, K43T, G48W, F53L	L10I, T12N, I13V, M36L, I62V, L63T, T74A, L89I	B
	48-6105	6105-30613	DQ878697	PI	NA	M46L, G48V, I54T, V82A, L90LM	L24LI, L33F, K43T	L10IV, E35D, M36L, N37D, Q61N, L63P, A71V, T74S, V77I, L89I, T91S, I93L	B
	48-6318	6318-30925	DQ878855	PI	NA	M46L, I84V, L90M	L10F, L33I, Q58E	T12AE, I13V, L19P, K20I, E35D, M36I, L63P, I64V, A71V, P79R, L89I, T91S, I93L	B
	48-6319	6319-30925	DQ878856	PI	NA	G48V, I54V, V82S, L90M	L33I, Q58QE	L10I, I13V, K20M, M36I, I62IV, L63P, C67C*WY, L89I	B
	48-7175	7175-30806	DQ879012	PI	NA	M46I, I54V, L76V, V82A		L10I, I13V, G16E, K20R, M36I, L63C, L89I, I93IL	B
	48-7196	7196-30729	DQ879023	PI	NA	M46L, G48V, I54V, V82A	K43T	L10V, I13V, I15V, Q18E, M36I, L38W, I62V, L63P, L89I	B
	48-9071	9071-30901	DQ877285	PI	NA	M46I, I47V, I54V, V82A, L90M	L33F, F53L, Q58E, N83D	L10V, G16A, K20R, E35D, M36I, N37D, R57K, D60E, Q61N, L63P, L89I	B
	48-9213	9213-30908	DQ877287	PI	NA	I54T, V82A, L90M	L33F, G48I, F53L	L10V, T12TI, I15V, G16A, K20R, E34EQ, E35D, M36I, N37D, R41K, R57K, I62V, L63P, A71I, I72V, L89I, I93L	B
	48-9286	9286-30929	DQ877301	PI	NA	M46I, L76V, I84V	L10F, L33F	I15V, G16E, K20V, M36L, N37NI, P39S, K55KR, I62V, T74S, I85V, L89I, T91A	B
	48-9062	9062-30820	DQ877477	PI	NA	M46I, I47IV, I54IL, L76V, I84V		L10V, I13V, I15V, G17E, Q18H, K20L, E35D, M36I, F53Y, D60DE, I62V, L63P, A71T, I72T, L89I, I93L	B
	48-9287	9287-30930	DQ877626	PI	NA	I54V, V82A, L90M	L10F	L19I, N37S, R57K, L63P, A71V, V77I, L89I, I93L	B
	48-9372	9372-30929	DQ877681	PI	NA	M46L, G48V, I54V, V82T, I84V		L10I, I13V, K14KN, G16E, K20R, M36I, L63T, H69Q, T74A, L89I	B
	48-9116	9116-30923	DQ877704	PI	NA	M46L, I54A, V82A, L90M		Q7K, L10I, I15V, K20R, E35D, M36I, N37NT, R41K, K55R, R57K, Q61N, L63V, A71V, I72T, I85V, L89I, Q92K, I93L	B
	48-7231	7231-30930	DQ879044	PI	NA	I54AV, V82A	L24I, L33F, F53L	L10I, I13V, G16E, E34EQ, M36L, N37NS, K55KR, I62V, L63C, A71AV, I72V, T74A, L89I	B
Santos (2006)	055	055PR_RT	AY275744	SQV, Unknown, IDV	>266			I15V, G17E, K20M, E35D, M36I, L63P, L89I	B
Dau (2010)	07946A	07946A	GU581883	PI	NA	M46I, I50V, I54V, L76V	L10F	T4S, L63P, H69Q, A71V, L89I	B
Jones (2012)	140306	140306	JN669588	PI	NA	M46I, I54L, L76V, I84V, L90LM		L10I, I15V, K20T, E35G, M36I, N37ND, D60E, I62V, L63P, A71V, I85V, L89I, I93L	B
	195155	195155	JN670966	PI	NA	D30N		E35D, M36V, K45R, I62V, L63A, A71T, V77I, L89I	B
	195200	195200	JN670969	PI	NA	M46I, I54A, V82F, L90M		L10V, T12P, I13V, I15V, Q18H, K20T, E35N, M36I, N37S, L63P, I64V, A71V, T74S, V77I, L89I, I93L	B

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