<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation L89I
Rx >= 1 PI
IncludeMixtures No
References 19
Patients 57
Isolates 65
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cabana (1999)Cab-bB41AF102281IDV40M46I, L76V, V82A, I84V L10I, I13V, Q18H, L63P, L89IB
  B44AF102282IDV, SQV, RTV74L76V L10I, I13V, L63P, L89IB
  B47AF102283IDV, SQV, RTV122M46I, L76V, V82A L10I, I13V, Q18H, I62V, L63P, L89IB
  B58AF102284IDV, SQV, RTV136M46I, L76V, I84V L10I, I13V, K14R, L63P, L89IB
Brun (2001)SB-PtESB-PtE-w16 SQV, RTV, IDV, LPV16I54V, V82A, L90M L10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61D, A71V, I72R, L89I, Q92KB
Gonzales (2001)CA3871CA9643AY030878SQV, IDV158I54A, V82F L10I, I13V, K14R, I15V, K20M, M36V, N37T, I62V, I64V, A71V, L89IB
 CA4118CA9810AY031108NFV39D30N E35D, M36I, R57K, L63P, L89I, I93LB
Kempf (2001)DK-3604DK-3604 SQV80I84V, L90MF53LL10I, N37NS, L63P, A71V, L89IB
 DK-94156367_d112 SQV, RTV, IDV, LPV149I54AV, V82A, L90M L10LI, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61D, A71V, I72R, L89I, Q92KB
  6367_d140 SQV, RTV, IDV, LPV153I54A, V82A, L90M L10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61D, A71V, I72R, L89I, Q92KB
  6367_d168 SQV, RTV, IDV, LPV157I54A, V82A, L90M L10I, I15V, G16E, K20R, E35D, M36I, R41K, R57K, Q61D, A71V, I72R, L89I, Q92KB
  6367_d427 SQV, RTV, IDV, LPV194M46I, I50V, I54V, V82A, L90M L10V, I15V, G16E, K20R, E35D, M36I, R41K, K55R, R57K, Q61N, I64IL, A71V, I72R, L89I, Q92KB
Brindeiro (2002)TVGG38TVGG38AY145801RTV, IDV, Unknown, NFV>66M46L, I54V, V82AL10F, I50FI15V, L63P, L89IB
Tural (2002)881506881506 RTV, IDV152M46I, L76V L10V, I13V, I15V, K20T, R41K, L63P, I64V, L89IB
Monno (2003)ML_Pat59ML_Pat59 PINAD30NL10F, N88DI13V, K20R, E35D, M36I, I62V, L63P, I64L, T74S, L89IB
Saah (2003)AS-41AS-41 NFV68L90M I15V, K20T, M36I, D60E, I62V, T74A, L89IB
Shafer (2003)A384_09010901d NFV, RTV, APV160I54L, I84V, L90ML33F, N83DL10I, K20R, E35N, M36L, N37D, I62V, L63P, A71V, L89IB
Wu (2003)CA3871CA11039AF544533SQV, IDV177I54A, V82F L10I, I13V, K14R, I15V, K20M, M36V, N37T, I62V, I64V, A71V, L89IB
 CA6800CA21370AF544598SQV, RTV, APV, IDV, LPV221M46L, I84VL33F, N83DT4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89IB
Colonno (2004)RC-008-039-230039-23021 NFV79D30NL10F, N88DT12S, L19Q, K20R, L63P, V77I, L89IB
Mueller (2004)MSM_pat5MLpat5_c PINAM46IT, I50V, I54V, L76VL10FT4S, L63P, H69Q, A71V, L89IB
Garcia-Bujalance (2005)GBS_04GBS_04AY872285RTV, NFV135M46LL23II13V, I15V, K20T, M36I, L63P, H69K, A71T, L89I, Q92RB
Rhee (2005)CA4345CA23508AY797060IDV, NFV, SQV, RTV, LPV277M46I, G48Q, I54T, V82F, L90ML33F, K43TL10I, K20R, E35D, M36I, N37D, R41K, Q61QE, I62V, L63T, I72V, V77I, L89I, I93LB
 CA6800CA21302AY797446SQV, RTV, APV, IDV, LPV217M46L, I84VL33F, N83DT4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89IB
Weber (2005)M62717M62717AY677383IDV, SQV, RTV, LPV142I54V, I84V, L90M I13AV, K14R, I15IV, K20IV, L24X, E35D, M36I, N37D, R41K, K45V, L63LP, I64IV, H69K, V82I, L89I, Q92QKB
Baxter (2006)12-10011001-30227DQ875949PINAG48GASW, I54T, V82AL33FL10I, V11L, G16A, L19V, K20R, E34Q, E35D, M36I, N37E, D60E, L63P, I64IL, A71V, V77I, L89I, I93LB
 12-12431243-30312DQ876074PINAM46I, I54M, L76V, V82T, L90MV11IL10I, T12IV, I15V, G16E, L19P, K20I, M36I, N37S, R41K_K, K55R, R57K, I62V, L63R, K70I, A71V, I85V, L89IB
 12-12491249-30304DQ876080PINAM46L, I54L, V82A, L90ML10F, L33F, K43TI13V, L24F, K55R, I62V, L63P, A71V, V77I, L89I, I93LB
 12-10031003-30303DQ876195PINAM46I, V82F, I84V, L90MQ58EL10I, I13V, I15V, K20I, D25DH, E35D, M36I, N37D, L63P, L89IB
 12-17741774-30708DQ876205PINAG48V, I54V, V82A, I84VV11I, L24I, K43TL10I, T12P, I13V, K20I, M36I, D60E, L63P, I64V, C67Y, L89IB
 12-23992399-30818DQ876221PINAV32I, M46I, I47V, I54L, I84V, L90ML10FYI15V, G16A, K20V, E34Q, L63Q, I64V, H69Q, T74S, V77I, I85V, L89I, T91S, Q92KB
 12-21512151-30623DQ876318PINAM46L, I54A, V82AL10F, K43KTI13V, Q18H, K20M, M36I, N37D, R41K, I62V, L63P, I64V, T74S, L89IB
 12-22142214-30722DQ876457PINAM46L, I54V, V82VA, I84IV, L90ML10FI13V, K20I, L24*, E35D, M36I, I62V, L63C, I64V, T74S, L89I, T91SB
 12-30533053-30402DQ876723PINAM46I, I54A, V82A, L90M L10I, I13V, K20I, L33L_L, E35D, M36I, N37D, I62V, L63P, A71V, L89IB
 12-22022202-30717DQ876901PINAM46I, I54V, I84V, L90ML10F, T74PI13V, L33M, K55R, R57K, I62V, L63P, C67CY, L89I, T91SB
 12-11901190-30310DQ876965PINAV32I, I47V, I54M, I84V, L90ML10F, L33FI13V, L19IT, K20R, E34A, E35D, M36I, K43Q, I62IV, L63P, A71I, P79S, L89IB
 12-20142014-30619DQ877078PINAM46L, I54V, L76V, V82A, L90M L10V, T12P, I15V, G16A, L19P, K20M, N37D, R41RK, I62V, L63P, A71V, I72T, L89I, Q92KB
 12-21492149-30813DQ877081PINAM46L, I54V, V82A, L90ML10F, V11II13V, K20I, M36I, N37S, R41K, I62V, L63P, A71I, I72L, L89I, T91MB
 12-30213021-30303DQ877232PINAM46I, I54V, I84V, L90ML10FI13V, I15V, K20T, E35D, M36I, I72V, L89IB
 48-11681168-30911DQ877356PINAI54V, V82A, I84VF53LL10V, T12E, I15V, K20R, E35D, M36I, R41K, K45R, R57K, Q61N, A71V, T74S, I85V, L89IB
 48-22272227-30430DQ877869PINAI54V, I84V, L90M L10LI, I13AV, K14R, K20IV, A22AV, E35D, M36I, N37D, R41K, K45V, L63LP, I64IV, I66IV, H69K, A71AT, V82I, L89I, Q92KB
 48-31383138-30416DQ878049PINAM46I, I54V, L76V, V82AK43T, Q58EL10V, I13V, K14R, G16E, K55R, R57RK, Q61H, L63H, K70E, L89IB
 48-31593159-30402DQ878068PINAI50V, I54V, V82AL10F, F53LK14R, I15V, L19P, K20I, E35N, M36I, N37D, R41T, K45V, I62V, I64V, A71V, I85V, L89IB
 48-32553255-30625DQ878159PINAI54S, V82M, L90ML33FL10V, I13V, I15V, K20R, E34EV, E35D, M36I, N37S, R41K, K55N, L63PT, A71V, V77VI, L89I, I93LB
 48-40984098-30521DQ878328PINAV32I, M46L, I54V, V82A, L90M T4TP, L10V, K14R, I15V, L19Q, K20R, M36I, L63P, A71V, L89I, Q92KB
 48-41044104-30224DQ878334PINAM46I, I54V, V82A, I84V, L90ML33F, F53FL, Q58ET4S, L10I, V11L, I13V, G16E, L19I, M36I, Q61R, L63T, L89I, T91SB
 48-50125012-30509DQ878547PINAI54V, V82A, L90ML33F, K43T, G48W, F53LL10I, T12N, I13V, M36L, I62V, L63T, T74A, L89IB
 48-61056105-30613DQ878697PINAM46L, G48V, I54T, V82A, L90LML24LI, L33F, K43TL10IV, E35D, M36L, N37D, Q61N, L63P, A71V, T74S, V77I, L89I, T91S, I93LB
 48-63186318-30925DQ878855PINAM46L, I84V, L90ML10F, L33I, Q58ET12AE, I13V, L19P, K20I, E35D, M36I, L63P, I64V, A71V, P79R, L89I, T91S, I93LB
 48-63196319-30925DQ878856PINAG48V, I54V, V82S, L90ML33I, Q58QEL10I, I13V, K20M, M36I, I62IV, L63P, C67C*WY, L89IB
 48-71757175-30806DQ879012PINAM46I, I54V, L76V, V82A L10I, I13V, G16E, K20R, M36I, L63C, L89I, I93ILB
 48-71967196-30729DQ879023PINAM46L, G48V, I54V, V82AK43TL10V, I13V, I15V, Q18E, M36I, L38W, I62V, L63P, L89IB
 48-90719071-30901DQ877285PINAM46I, I47V, I54V, V82A, L90ML33F, F53L, Q58E, N83DL10V, G16A, K20R, E35D, M36I, N37D, R57K, D60E, Q61N, L63P, L89IB
 48-92139213-30908DQ877287PINAI54T, V82A, L90ML33F, G48I, F53LL10V, T12TI, I15V, G16A, K20R, E34EQ, E35D, M36I, N37D, R41K, R57K, I62V, L63P, A71I, I72V, L89I, I93LB
 48-92869286-30929DQ877301PINAM46I, L76V, I84VL10F, L33FI15V, G16E, K20V, M36L, N37NI, P39S, K55KR, I62V, T74S, I85V, L89I, T91AB
 48-90629062-30820DQ877477PINAM46I, I47IV, I54IL, L76V, I84V L10V, I13V, I15V, G17E, Q18H, K20L, E35D, M36I, F53Y, D60DE, I62V, L63P, A71T, I72T, L89I, I93LB
 48-92879287-30930DQ877626PINAI54V, V82A, L90ML10FL19I, N37S, R57K, L63P, A71V, V77I, L89I, I93LB
 48-93729372-30929DQ877681PINAM46L, G48V, I54V, V82T, I84V L10I, I13V, K14KN, G16E, K20R, M36I, L63T, H69Q, T74A, L89IB
 48-91169116-30923DQ877704PINAM46L, I54A, V82A, L90M Q7K, L10I, I15V, K20R, E35D, M36I, N37NT, R41K, K55R, R57K, Q61N, L63V, A71V, I72T, I85V, L89I, Q92K, I93LB
 48-72317231-30930DQ879044PINAI54AV, V82AL24I, L33F, F53LL10I, I13V, G16E, E34EQ, M36L, N37NS, K55KR, I62V, L63C, A71AV, I72V, T74A, L89IB
Santos (2006)055055PR_RTAY275744SQV, Unknown, IDV>266  I15V, G17E, K20M, E35D, M36I, L63P, L89IB
Dau (2010)07946A07946AGU581883PINAM46I, I50V, I54V, L76VL10FT4S, L63P, H69Q, A71V, L89IB
Jones (2012)140306140306JN669588PINAM46I, I54L, L76V, I84V, L90LM L10I, I15V, K20T, E35G, M36I, N37ND, D60E, I62V, L63P, A71V, I85V, L89I, I93LB
 195155195155JN670966PINAD30N E35D, M36V, K45R, I62V, L63A, A71T, V77I, L89IB
 195200195200JN670969PINAM46I, I54A, V82F, L90M L10V, T12P, I13V, I15V, Q18H, K20T, E35N, M36I, N37S, L63P, I64V, A71V, T74S, V77I, L89I, I93LB