<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation N88S
Rx >= 1 PI
IncludeMixtures No
References 34
Patients 117
Isolates 143
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Patick (1998)503-152503-152W28 NFV28M46I, N88SQ58EI13V, K14R, I15V, K20I, N37S, R41KB
 503-63503-63W12 NFV12N88S, L90M L10I, I13V, G16E, K20M, I62V, L63P, H69P, Q92KB
 503-223503-223W20 NFV20N88S L10I, T12X, I13V, E35D, M36V, N37D, P39X, I62V, L63P, A71V, V77I, V82IB
Zolopa (1999)CA1289CA3211AF085120SQV, NFV73N88S, L90MK43TR57K, I62V, L63P, A71XB
Atkinson (2000)BA18BA18AF247862NFV16N88S N37D, L63LP, I64IV, V77I, P81PLB
 BA19BA19AF247863NFV16M46I, N88S, L90M K20X, L63A, T74TS, V77IB
 BA4BA4AF247878NFV1N88S I15V, K20KR, M36I, I62V, L63HP, I72VB
  BA4_v3AF247898NFV11N88S P9X, R41K, I64VB
Bacheler (2000)LB3-P72P72-16 IDV16N88S L10I, E35D, L63P, H69Q, I72VB
 LB3-P80P80-36 IDV36M46I, N88S E35D, L63P, I72VB
  P80-74 IDV74M46I, N88S E35D, L63P, I72V, I93LB
  P80-100 IDV100M46I, N88S E35D, L63P, I72V, I93LB
Baxter (2000)GART-G48GART-48 PI, IDVNAM46I, N88S, L90LMQ58QEI62V, L63P, V77I, I93LB
 GART-G140GART-140 PI, IDVNAM46L, N88SL10FN37D, Q61E, K70R, V77IB
Belec (2000)nr72nr72_m12AF204393IDV52M46I, I84V, N88ST74PL10I, E35D, N37H, R41K, R57K, Y59F, L63P, A71V, I72V, V77I, I93LB
Masciotra (2000)SM5SM5AF221030PINAI54V, V82A, N88S E35G, L63P, V77I, T96SB
Rousseau (2000)MNR13MNR4705AJ405958IDV, SQV, RTV, NFV94M46I, N88S, L90ML33I, Q58EL10V, T12P, I13V, K14R, K20T, M36I, I62V, L63P, H69H_NGQCV, A71T, I72T, I93LB
Brun (2001)SB-PtCSB-PtC-BL NFV M46I, N88S, L90M L10M, I13V, Q18H, N37D, K55R, Q61H, L63P, A71T, I72T, V77I, I93LB
Gonzales (2001)CA1118CA2519AY030435PINAN88S K20T, E35D, M36I, R57K, I62V, L63P, A71T, V77I, I93LB
 CA1390CA3641AY030544SQV, IDV81M46MI, N88S L10I, E35D, N37D, D60E, L63P, I64V, V77I, I93LB
 CA1405CA3772AY030550IDV, NFV95M46MI, N88S L63A, I72V, V77IB
 CA1408CA3778AY030553IDV, NFV101M46I, N88S L10V, I13V, E35D, N37D, I62V, L63P, I64V, A71T, I72V, V77I, I93LB
 CA1625CA4607AY030713IDV101N88S L63PB
 CA1813CA4868AY030728IDV63M46L, N88S L10LI, I13V, I15V, E35D, M36I, I62V, L63P, I93LB
 CA1870CA5001AY030774Unknown, SQV, NFV, RTV>71M46I, N88S L10V, E35D, N37E, L63P, I64V, I93LB
 CA2084CA7713AY030792IDV, NFV98M46I, N88SL10F, Q58QEI13V, K14R, K20I, N37D, L63Q, I64V, I72V, I93LB
 CA2105CA7763AY030812IDV, NFV127M46I, N88S T12S, L19I, R57K, L63P, V77I, I93LB
 CA3968CA9722AY030966IDV, SQV157M46MI, N88S L10I, I15V, Q18H, L63P, T74S, I93LB
 CA3981CA9570AY030980NFV62N88S I15V, K20T, E35X, M36I, D60E, I62V, I64V, I72VB
 CA4162CA9997AY031139IDV37M46I, V82T, N88S L10V, I13V, N37D, R57RK, L63P, A71V, I93LB
 CA4325CA10725AY031189IDV, NFV157M46I, V82T, N88S L10I, L19S, I62V, L63P, A71V, I85V, I93LB
 CA4330CA10730AY031194RTV, IDV, NFV170M46I, N88S L63PB
 CA4504CA11085AY031343IDV, NFV157M46I, N88SQ58E, L89VL10I, I62V, L63P, I72V, V77I, I93LB
 CA4578CA11229AY031375IDV156N88S L10I, M46X, I62V, L63S, V77I, I93ILB
 CA4725CA11748AY031387IDV, NFV165M46I, N88S T12R, L19I, N37D, I62V, V77IB
 CA4870CA12059AY031510IDV153M46I, N88S L10V, I13V, K14R, R41K, Q61H, L63P, A71T, I93LB
 CA5056CA12620AY031626NFV, SQV, RTV105M46I, N88S, L90M L10V, R41K, Q61H, L63P, K70R, V77IB
 CA5205CA12785AY031768IDV, NFV149M46I, N88S L10I, I13V, K20I, L63P, I64V, I93LB
 CA5551CA13761AY032058NFV71M46I, N88S K20KQ, V77IB
 CA5699CA14575AY032101IDV, NFV193N88SL10LFK20I, R41K, L63P, A71T, V77VIB
 CA5773CA14321AY032163IDV, NFV190N88S I15V, L19I, N37D, L63P, V75VI, I93LB
 CA5961CA14873AY032209NFV56M46L, N88S D60E, Q61E, L63PB
 CA6339CA16055AY032298NFV43N88S R41K, L63P, V77I, I93LB
 CA6791CA17079AY032524Unknown, IDV>78N88S, L90ML10FI15V, K20T, E35D, M36I, R41K, R57K, I62V, L63P, I64IL, I66IV, A71T, I93LB
 CA6797CA17087AY032530NFV49M46MI, N88S E35D, N37D, L63P, I64V, V77I, I93LB
 CA6804CA17095AY032537IDV, NFV178M46I, N88S L10I, I13IV, K43KN, Q58QL, I62V, L63P, T74TS, V77I, Q92R, I93LB
Kempf (2001)DK-404DK-404 IDV45M46I, N88S I62V, L63P, I93LB
 DK-2314DK-2314 NFV133M46I, N88S, L90M L10IM, I13V, Q18H, N37D, K55KR, Q61QH, L63P, A71T, I72T, V77I, I93LB
 DK-2715DK-2715 IDV, RTV30M46ML, I54V, V82A, N88S, L90ML33F, Q58E, G73TSL10I, I13V, K55KR, I62IV, L63P, A71V, V77IB
 DK-6273DK-6273 NFV47N88S E35D, N37D, K45KR, L63P, I64V, I72VB
 DK-9233DK-9233 IDV43M46I, N88S L10I, I15V, Q18H, K20I, E35D, N37D, L63P, I93LB
Zachary (2001)KZ-CIDKZ-CID1 IDV, NFV139N88S I64VB
  KZ-CID2 IDV, NFV175N88S L10I, I64V, V77IB
Kantor (2002)CA793CA8012AY047394SQV, NFV, IDV186M46I, N88S I13V, I15V, E35D, M36L, N37S, R41K, I62V, L63P, A71T, I72IV, I93LB
 CA1289CA3312AY047415SQV, NFV, RTV88N88S, L90MK43TL10LI, R57K, I62V, L63P, A71TB
Margot (2002)MM-5535366295535366291 PINAN88S L10I, I13V, K20T, E35D, M36I, N37D, D60E, Q61D, I62V, L63P, C67Y, I72TB
 MM-2149365662149365661 PINAI54L, N88S, L90MG73STL10I, I15V, K20T, E35D, M36I, R41K, K45R, R57K, I62V, L63P, A71T, I72T, I93LB
 MM-2375366642375366641 PINAM46I, N88S L10I, I13V, K20I, L63P, T74S, V77IB
 MM-3727366833727366831 PINAM46I, N88S L10I, I13V, E35D, N37D, D60E, I62V, L63P, I72V, V77I, I93LB
 MM-2739365462739365461 PINAM46L, N88S K20KM, I62V, L63A, A71V, T74S, V77IB
Masquelier (2002)apv5apv5M8AY133498NFV32N88S T12I, R41K, I62V, L63P, V77VIB
  apv5M10AY133499NFV40M46ML, N88S T12I, R41K, I62V, L63P, V77IB
Tural (2002)110634110634 IDV80M46I, N88SL33IN37S, R41K, L63P, V77I, I93LB
 297033297033 IDV60M46I, N88S L10I, E35D, N37T, I62V, L63P, A71T, V77I, I93LB
 880810880810 IDV68N88S E35D, M36I, R57K, I62V, L63P, I72V, L90SB
Gonzales (2003)CA5205CA24665AY305993IDV, NFV, SQV, RTV252M46I, N88S, L90MQ58QEL10I, I13V, K20I, L63P, A71T, I93LB
Monno (2003)ML_pt10ML131AY267789IDV, NFV34N88S L10I, I13V, K20R, N37D, L63P, A71T, V77IB
Shafer (2003)A384_24362436cEF548319NFV50N88S N37S, I62V, L63P, V77IB
 A384_19561956bEF548643NFV104N88S I13V, I15V, M36I, I62V, L63PB
 A384_11521152bEF548964NFV111N88S L10I, L63P, A71T, I72TB
 A384_01360136cEF549245NFV24N88S E35D, M36V, P39Q, R41K, L63P, A71V, I93LB
 A384_16231623bEF549216NFV21M46L, N88S I13V, E35D, N37S, R57K, D60E, L63PB
Wu (2003)CA1317CA9804AF544457IDV, SQV57N88S, L90M I15V, K20T, E35D, M36I, R41RK, R57K, I62V, L63P, C67CY, A71XB
  CA35534AY798448IDV, SQV90N88S, L90ML10FI15V, K20AT, E35D, M36I, R41K, R57K, I62V, L63P, C67Y, I93LB
 CA1320CA4310AF544459NFV39N88S N37S, I64V, V77IB
 CA1405CA10744AF544467IDV, NFV, SQV157M46ML, N88S Q2Q*, L63A, I72V, V77IB
 CA1408CA8383AF544469IDV, NFV141M46I, N88S L10V, I13V, K20KR, E35D, N37D, I62V, L63P, I64V, A71T, I72V, V77I, I93LB
 CA1439CA11081AF544476SQV, RTV, NFV115N88S N37NS, I62V, A71I, I72T, V77I, I93LB
 CA1592CA9703AF544504RTV, IDV, NFV35M46I, N88S K14KR, I15IV, N37D, I62V, L63A, V77I, I93LB
 CA2084CA8472AF544524IDV, NFV, SQV112M46I, N88SL10F, Q58EI13V, K14R, K20I, N37D, L63Q, I64V, I72V, I93LB
 CA2105CA14874AF544528IDV, NFV, SQV, RTV197M46I, N88S, L90M T12S, L19I, R57K, L63P, A71T, V77I, I93LB
Colonno (2004)RC-009-012-047012-04711 NFV N88SL10FI13V, N37D, L63P, V77I, I93LB
  012-04721 NFV, SQV, ATV63M46I, I54L, I84V, N88SL10FI13V, N37D, I62V, L63P, A71X, V77G, I93LB
 RC-009-014-023014-02311 NFV D30N, M46I, N88S L10I, I13V, E35D, N37Y, R41K, L63Q, I64V, I72V, V77I, I85VB
  014-02321 NFV, SQV, ATV68M46I, I84V, N88SL23IL10I, I13V, E35D, N37Y, R41K, L63X, A71T, V77I, L89MB
Dumans (2004)252252AY390059RTV, NFV221N88S, L90M L10I, L19I, N37S, K45R, L63P, A71T, V77I, I93LB
Gomez-Carrillo (2004)106543106543AY365752PINAM46I, N88S, L90M T4P, L10I, K14R, I15V, K20V, M36I, I62V, L63P, G73D, Q92K, I93LB
 110289110289AY365834PINAN88S T12K, I15V, L19I, K20T, E35D, M36I, N37E, R57K, Q61N, L63V, I72TB
 119929119929AY365975PINAM46I, N88S I13V, I62V, L63P, A71AT, I72T, V77I, I93LB
Machado (2004)cs196cs196AY313360NFV93M46I, N88S L10I, T12S, I13V, L19I, K20I, E35D, N37H, R41K, K45R, L63P, V77IB
Garcia-Bujalance (2005)GBS_19GBS_19AY872300NFV N88S T12P, K14R, E35D, N37D, L63P, I93LB
 GBS_20GBS_20AY872301IDV, NFV N88S L10V, I13V, I15IV, G16A, K20T, K45KR, I62V, I64V, V77IB
Rhee (2005)CA1317CA7991AY796611IDV36N88S I15V, K20T, E35D, M36I, R57K, L63P, I93ILB
  CA12807AY796612IDV, SQV85N88S, L90ML10FI15V, K20T, E35D, M36I, R41K, R57K, I62V, L63P, C67CY, A71AT, I93LB
 CA1405CA9783AY796654IDV, NFV, SQV151M46ML, N88S L63A, I72V, V77IB
 CA1625CA13280AY796812IDV, NFV166N88SL10LFL5LF, E34D, M36V, L63P, I93ILB
  CA16541AF544507IDV, NFV194N88S E34D, M36V, I62V, L63P, I93LB
 CA1813CA9691AY796820IDV, SQV, RTV98M46L, N88S, L90M L10V, I13V, I15V, K20M, E35D, M36I, I62V, L63P, A71T, I93LB
 CA4301CA38056AY797042IDV, SQV, RTV, NFV, LPV, ATV350M46I, N88S N37D, V77IB
 SWC-64596459-2425 IDV, NFV110M46I, N88S L19I, R41K, V77I, Q92XB
  6459-4252 IDV, NFV212M46I, N88S L19I, R41K, V77IB
 ASRU006ASRU006 SQV, NFV91N88S L10V, I13V, K14R, I15V, K20I, M36IB
 CA4870CA21287AY797182IDV157M46I, N88S L10IV, I13V, K14KR, R41K, Q61H, L63P, A71AT, T74TS, I93LB
 CA5205CA16120AY797265IDV, NFV, SQV, RTV171M46I, N88S L10I, I13V, K20I, L63P, I64V, I93LB
 CA5551CA37827AY797347NFV, RTV241M46I, N88S, L90LMQ58EK20L, I62V, L63P, A71T, T74S, V77IB
 CA6804CA20598AY797448IDV, NFV183M46I, N88S L10IV, I62V, L63P, T74TS, V77I, Q92R, I93LB
 CA7087CA17577AY797510NFV175N88SQ58EL10V, I13V, K20I, M46X, I62V, L63P, V77IB
 CA7931CA20391AY797597NFV80N88SL10FI13V, K20T, E35D, M36IL, R41K, I62V, L63LP, I64VB
 CA8010CA33719AY797643NFV104M46MI, N88SL10LF, Q58QEK45KR, R57RK, L63P, V77I, I93ILB
  CA37781AY797644NFV142M46MI, N88SL10F, Q58QEK45KR, R57RK, L63P, V77I, I93LB
 CA8385CA21332AY797728IDV, NFV164D30DN, N88S I15IV, L63P, V77IB
 CA9937CA24568AY797943IDV134M46I, N88S I13V, N37T, I62V, L63P, I64IL, V77I, I93LB
 CA14345CA33559AY798052SQV, IDV, NFV304N88SL23LI, L33FI13V, N37S, P39S, D60E, A71V, V77IB
 CA14581CA33959AY798124NFV189N88S L10I, I13V, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I72V, I93LB
 CA14642CA34049AY798134IDV, NFV169N88SM46MVL10I, Q18H, E35D, N37S, R41K, L63P, I72V, I93LB
 CA18429CA43005AY798305NFV180N88SL10FT12P, K14R, I15V, G16E, K20T, R57RK, I62V, L63N, V77IB
Baxter (2006)12-22752275-30725DQ876026PINAM46I, I84V, N88SL10F, L33FI13V, L19V, K20T, R57K, L63P, A71T, V77IB
 12-21072107-30626DQ876434PINAM46I, I54IL, N88SL10F, Q58EI13V, M36MI, N37E, I62IV, L63S, V77I, L89M, I93LB
 48-14381438-30513DQ877828PINAM46I, N88S L10I, I15V, K20T, E35D, L63P, I93LB
 48-22112211-30526DQ877864PINAI54M, N88S, L90M L10I, K14R, I15V, L19T, K20T, E34EQ, E35DN, M36I, N37S, L63LP, A71I, G73GD, T74S, V77I, I85V, Q92K, I93LB
 48-71257125-30902DQ878968PINAM46L, N88SL33LFL10I, T12TK, I13V, K14KR, I15V, K20I, R41K, L63P, A71T, I93LB
 48-92309230-30915DQ877640PINAM46I, I84V, N88S L10I, I13V, L19V, K20I, E35ED, N37S, L63P, I66IV, A71T, I72IT, I85IV, I93LB
Rhee (2006)CA8384CA21331DQ316712IDV, RTV171N88S, L90MQ58EL10I, I15V, K20T, E35D, M36I, I62V, L63P, A71T, I85IVB
von Wyl (2007)115732708EF449791PINAN88S, L90LMM46MVL10LI, T12A, K14R, I15V, Q18I, K20T, R41K, L63P, V77IB
 975247096EF449924PINAM46L, N88S, L90M K14R, E35D, M36V, R41K, I62V, L63P, G68E, A71V, I93L, L97F, N98KB
 1081435942EF449983PINAN88SL10FV77I, I93LB
Zolopa (2007)3AZ_3 ATV24N88S T12K, L19V, K20KT, E34EQ, E35D, M36MV, N37X, R41K, K45R, R57K, L63P, I64L, A71T, V77I, I93LB
Dumans (2009)PA262PA262DQ659460SQV, IDV26N88S N37T, R41K, H69KB
Rhee (2009)CA8468CA21458FJ983301NFV175N88S I15IV, K20KM, E35D, M36IV, R41K, I62V, L63HQ, A71V, I72T, I93LB
 CA9642CA23540FJ983309IDV, NFV215N88S L10I, M36I, K45KR, R57K, L63P, I93LB
 CA14266CA33433FJ983355IDV, NFV, SQV, RTV215M46I, N88S, L90MF53FLL10I, I13V, K14R, N37D, L63P, A71IT, I72X, V77VI, I93LB
Dau (2010)08710A08710AGU581939PINAN88S I15V, N37E, L63V, K70RB
 10962A10962AGU582026PINAM46MI, N88SL23IL10I, I13V, L63P, I64IM, V77I, I93LB
 11056A11056AGU582031PINAM46I, N88S I13V, R57K, L63P, V77IB
Jones (2012)137172137172JN669560PINAN88SL10F, L33II13V, M36L, I62V, L63PB
 147928147928JN669704PINAN88S K20MR, E35D, M36I, N37D, R41RK, K43KR, K45KR, I62IV, L63P, H69K, I93LB
 152323152323JN669777PINAM46I, N88S T12N, L19I, R41K, L63P, V77I, I93LB
 154205154205JN669812PINAM46I, N88S L63S, V77IB
 156694156694JN669872PINAM46ML, N88S L10I, N37S, R41K, L63P, I93LB
 156863156863JN669875PINAM46MI, I50IL, N88S L10I, T12PS, L19T, K20LM, E21EQ, L33LV, K45R, R57RK, L63P, A71T, I85V, I93LB
 181264181264JN670572PINAM46I, N88SL89VL10I, I13V, K14R, I62V, L63P, Q92K, I93LB
 194994194994JN670958PINAI50L, N88SL33FI13IV, L19V, E34EQ, N37S, R41K, K45R, L63P, A71I, V77VI, I93LB
 196066196066JN671011PINAN88S L10I, T12K, I15V, L19M, K20T, E35D, M36I, R41K, R57K, Q61N, A71TB