Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	B
Gene	PR
Mutation	N88S
Rx	>= 1 PI
IncludeMixtures	No

References	34
Patients	117
Isolates	143

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Patick (1998)	503-152	503-152W28		NFV	28	M46I, N88S	Q58E	I13V, K14R, I15V, K20I, N37S, R41K	B
	503-63	503-63W12		NFV	12	N88S, L90M		L10I, I13V, G16E, K20M, I62V, L63P, H69P, Q92K	B
	503-223	503-223W20		NFV	20	N88S		L10I, T12X, I13V, E35D, M36V, N37D, P39X, I62V, L63P, A71V, V77I, V82I	B
Zolopa (1999)	CA1289	CA3211	AF085120	SQV, NFV	73	N88S, L90M	K43T	R57K, I62V, L63P, A71X	B
Atkinson (2000)	BA18	BA18	AF247862	NFV	16	N88S		N37D, L63LP, I64IV, V77I, P81PL	B
	BA19	BA19	AF247863	NFV	16	M46I, N88S, L90M		K20X, L63A, T74TS, V77I	B
	BA4	BA4	AF247878	NFV	1	N88S		I15V, K20KR, M36I, I62V, L63HP, I72V	B
		BA4_v3	AF247898	NFV	11	N88S		P9X, R41K, I64V	B
Bacheler (2000)	LB3-P72	P72-16		IDV	16	N88S		L10I, E35D, L63P, H69Q, I72V	B
	LB3-P80	P80-36		IDV	36	M46I, N88S		E35D, L63P, I72V	B
		P80-74		IDV	74	M46I, N88S		E35D, L63P, I72V, I93L	B
		P80-100		IDV	100	M46I, N88S		E35D, L63P, I72V, I93L	B
Baxter (2000)	GART-G48	GART-48		PI, IDV	NA	M46I, N88S, L90LM	Q58QE	I62V, L63P, V77I, I93L	B
	GART-G140	GART-140		PI, IDV	NA	M46L, N88S	L10F	N37D, Q61E, K70R, V77I	B
Belec (2000)	nr72	nr72_m12	AF204393	IDV	52	M46I, I84V, N88S	T74P	L10I, E35D, N37H, R41K, R57K, Y59F, L63P, A71V, I72V, V77I, I93L	B
Masciotra (2000)	SM5	SM5	AF221030	PI	NA	I54V, V82A, N88S		E35G, L63P, V77I, T96S	B
Rousseau (2000)	MNR13	MNR4705	AJ405958	IDV, SQV, RTV, NFV	94	M46I, N88S, L90M	L33I, Q58E	L10V, T12P, I13V, K14R, K20T, M36I, I62V, L63P, H69H_NGQCV, A71T, I72T, I93L	B
Brun (2001)	SB-PtC	SB-PtC-BL		NFV		M46I, N88S, L90M		L10M, I13V, Q18H, N37D, K55R, Q61H, L63P, A71T, I72T, V77I, I93L	B
Gonzales (2001)	CA1118	CA2519	AY030435	PI	NA	N88S		K20T, E35D, M36I, R57K, I62V, L63P, A71T, V77I, I93L	B
	CA1390	CA3641	AY030544	SQV, IDV	81	M46MI, N88S		L10I, E35D, N37D, D60E, L63P, I64V, V77I, I93L	B
	CA1405	CA3772	AY030550	IDV, NFV	95	M46MI, N88S		L63A, I72V, V77I	B
	CA1408	CA3778	AY030553	IDV, NFV	101	M46I, N88S		L10V, I13V, E35D, N37D, I62V, L63P, I64V, A71T, I72V, V77I, I93L	B
	CA1625	CA4607	AY030713	IDV	101	N88S		L63P	B
	CA1813	CA4868	AY030728	IDV	63	M46L, N88S		L10LI, I13V, I15V, E35D, M36I, I62V, L63P, I93L	B
	CA1870	CA5001	AY030774	Unknown, SQV, NFV, RTV	>71	M46I, N88S		L10V, E35D, N37E, L63P, I64V, I93L	B
	CA2084	CA7713	AY030792	IDV, NFV	98	M46I, N88S	L10F, Q58QE	I13V, K14R, K20I, N37D, L63Q, I64V, I72V, I93L	B
	CA2105	CA7763	AY030812	IDV, NFV	127	M46I, N88S		T12S, L19I, R57K, L63P, V77I, I93L	B
	CA3968	CA9722	AY030966	IDV, SQV	157	M46MI, N88S		L10I, I15V, Q18H, L63P, T74S, I93L	B
	CA3981	CA9570	AY030980	NFV	62	N88S		I15V, K20T, E35X, M36I, D60E, I62V, I64V, I72V	B
	CA4162	CA9997	AY031139	IDV	37	M46I, V82T, N88S		L10V, I13V, N37D, R57RK, L63P, A71V, I93L	B
	CA4325	CA10725	AY031189	IDV, NFV	157	M46I, V82T, N88S		L10I, L19S, I62V, L63P, A71V, I85V, I93L	B
	CA4330	CA10730	AY031194	RTV, IDV, NFV	170	M46I, N88S		L63P	B
	CA4504	CA11085	AY031343	IDV, NFV	157	M46I, N88S	Q58E, L89V	L10I, I62V, L63P, I72V, V77I, I93L	B
	CA4578	CA11229	AY031375	IDV	156	N88S		L10I, M46X, I62V, L63S, V77I, I93IL	B
	CA4725	CA11748	AY031387	IDV, NFV	165	M46I, N88S		T12R, L19I, N37D, I62V, V77I	B
	CA4870	CA12059	AY031510	IDV	153	M46I, N88S		L10V, I13V, K14R, R41K, Q61H, L63P, A71T, I93L	B
	CA5056	CA12620	AY031626	NFV, SQV, RTV	105	M46I, N88S, L90M		L10V, R41K, Q61H, L63P, K70R, V77I	B
	CA5205	CA12785	AY031768	IDV, NFV	149	M46I, N88S		L10I, I13V, K20I, L63P, I64V, I93L	B
	CA5551	CA13761	AY032058	NFV	71	M46I, N88S		K20KQ, V77I	B
	CA5699	CA14575	AY032101	IDV, NFV	193	N88S	L10LF	K20I, R41K, L63P, A71T, V77VI	B
	CA5773	CA14321	AY032163	IDV, NFV	190	N88S		I15V, L19I, N37D, L63P, V75VI, I93L	B
	CA5961	CA14873	AY032209	NFV	56	M46L, N88S		D60E, Q61E, L63P	B
	CA6339	CA16055	AY032298	NFV	43	N88S		R41K, L63P, V77I, I93L	B
	CA6791	CA17079	AY032524	Unknown, IDV	>78	N88S, L90M	L10F	I15V, K20T, E35D, M36I, R41K, R57K, I62V, L63P, I64IL, I66IV, A71T, I93L	B
	CA6797	CA17087	AY032530	NFV	49	M46MI, N88S		E35D, N37D, L63P, I64V, V77I, I93L	B
	CA6804	CA17095	AY032537	IDV, NFV	178	M46I, N88S		L10I, I13IV, K43KN, Q58QL, I62V, L63P, T74TS, V77I, Q92R, I93L	B
Kempf (2001)	DK-404	DK-404		IDV	45	M46I, N88S		I62V, L63P, I93L	B
	DK-2314	DK-2314		NFV	133	M46I, N88S, L90M		L10IM, I13V, Q18H, N37D, K55KR, Q61QH, L63P, A71T, I72T, V77I, I93L	B
	DK-2715	DK-2715		IDV, RTV	30	M46ML, I54V, V82A, N88S, L90M	L33F, Q58E, G73TS	L10I, I13V, K55KR, I62IV, L63P, A71V, V77I	B
	DK-6273	DK-6273		NFV	47	N88S		E35D, N37D, K45KR, L63P, I64V, I72V	B
	DK-9233	DK-9233		IDV	43	M46I, N88S		L10I, I15V, Q18H, K20I, E35D, N37D, L63P, I93L	B
Zachary (2001)	KZ-CID	KZ-CID1		IDV, NFV	139	N88S		I64V	B
		KZ-CID2		IDV, NFV	175	N88S		L10I, I64V, V77I	B
Kantor (2002)	CA793	CA8012	AY047394	SQV, NFV, IDV	186	M46I, N88S		I13V, I15V, E35D, M36L, N37S, R41K, I62V, L63P, A71T, I72IV, I93L	B
	CA1289	CA3312	AY047415	SQV, NFV, RTV	88	N88S, L90M	K43T	L10LI, R57K, I62V, L63P, A71T	B
Margot (2002)	MM-553536629	5535366291		PI	NA	N88S		L10I, I13V, K20T, E35D, M36I, N37D, D60E, Q61D, I62V, L63P, C67Y, I72T	B
	MM-214936566	2149365661		PI	NA	I54L, N88S, L90M	G73ST	L10I, I15V, K20T, E35D, M36I, R41K, K45R, R57K, I62V, L63P, A71T, I72T, I93L	B
	MM-237536664	2375366641		PI	NA	M46I, N88S		L10I, I13V, K20I, L63P, T74S, V77I	B
	MM-372736683	3727366831		PI	NA	M46I, N88S		L10I, I13V, E35D, N37D, D60E, I62V, L63P, I72V, V77I, I93L	B
	MM-273936546	2739365461		PI	NA	M46L, N88S		K20KM, I62V, L63A, A71V, T74S, V77I	B
Masquelier (2002)	apv5	apv5M8	AY133498	NFV	32	N88S		T12I, R41K, I62V, L63P, V77VI	B
		apv5M10	AY133499	NFV	40	M46ML, N88S		T12I, R41K, I62V, L63P, V77I	B
Tural (2002)	110634	110634		IDV	80	M46I, N88S	L33I	N37S, R41K, L63P, V77I, I93L	B
	297033	297033		IDV	60	M46I, N88S		L10I, E35D, N37T, I62V, L63P, A71T, V77I, I93L	B
	880810	880810		IDV	68	N88S		E35D, M36I, R57K, I62V, L63P, I72V, L90S	B
Gonzales (2003)	CA5205	CA24665	AY305993	IDV, NFV, SQV, RTV	252	M46I, N88S, L90M	Q58QE	L10I, I13V, K20I, L63P, A71T, I93L	B
Monno (2003)	ML_pt10	ML131	AY267789	IDV, NFV	34	N88S		L10I, I13V, K20R, N37D, L63P, A71T, V77I	B
Shafer (2003)	A384_2436	2436c	EF548319	NFV	50	N88S		N37S, I62V, L63P, V77I	B
	A384_1956	1956b	EF548643	NFV	104	N88S		I13V, I15V, M36I, I62V, L63P	B
	A384_1152	1152b	EF548964	NFV	111	N88S		L10I, L63P, A71T, I72T	B
	A384_0136	0136c	EF549245	NFV	24	N88S		E35D, M36V, P39Q, R41K, L63P, A71V, I93L	B
	A384_1623	1623b	EF549216	NFV	21	M46L, N88S		I13V, E35D, N37S, R57K, D60E, L63P	B
Wu (2003)	CA1317	CA9804	AF544457	IDV, SQV	57	N88S, L90M		I15V, K20T, E35D, M36I, R41RK, R57K, I62V, L63P, C67CY, A71X	B
		CA35534	AY798448	IDV, SQV	90	N88S, L90M	L10F	I15V, K20AT, E35D, M36I, R41K, R57K, I62V, L63P, C67Y, I93L	B
	CA1320	CA4310	AF544459	NFV	39	N88S		N37S, I64V, V77I	B
	CA1405	CA10744	AF544467	IDV, NFV, SQV	157	M46ML, N88S		Q2Q*, L63A, I72V, V77I	B
	CA1408	CA8383	AF544469	IDV, NFV	141	M46I, N88S		L10V, I13V, K20KR, E35D, N37D, I62V, L63P, I64V, A71T, I72V, V77I, I93L	B
	CA1439	CA11081	AF544476	SQV, RTV, NFV	115	N88S		N37NS, I62V, A71I, I72T, V77I, I93L	B
	CA1592	CA9703	AF544504	RTV, IDV, NFV	35	M46I, N88S		K14KR, I15IV, N37D, I62V, L63A, V77I, I93L	B
	CA2084	CA8472	AF544524	IDV, NFV, SQV	112	M46I, N88S	L10F, Q58E	I13V, K14R, K20I, N37D, L63Q, I64V, I72V, I93L	B
	CA2105	CA14874	AF544528	IDV, NFV, SQV, RTV	196	M46I, N88S, L90M		T12S, L19I, R57K, L63P, A71T, V77I, I93L	B
Colonno (2004)	RC-009-012-047	012-04711		NFV		N88S	L10F	I13V, N37D, L63P, V77I, I93L	B
		012-04721		NFV, SQV, ATV	63	M46I, I54L, I84V, N88S	L10F	I13V, N37D, I62V, L63P, A71X, V77G, I93L	B
	RC-009-014-023	014-02311		NFV		D30N, M46I, N88S		L10I, I13V, E35D, N37Y, R41K, L63Q, I64V, I72V, V77I, I85V	B
		014-02321		NFV, SQV, ATV	68	M46I, I84V, N88S	L23I	L10I, I13V, E35D, N37Y, R41K, L63X, A71T, V77I, L89M	B
Dumans (2004)	252	252	AY390059	RTV, NFV	221	N88S, L90M		L10I, L19I, N37S, K45R, L63P, A71T, V77I, I93L	B
Gomez-Carrillo (2004)	106543	106543	AY365752	PI	NA	M46I, N88S, L90M		T4P, L10I, K14R, I15V, K20V, M36I, I62V, L63P, G73D, Q92K, I93L	B
	110289	110289	AY365834	PI	NA	N88S		T12K, I15V, L19I, K20T, E35D, M36I, N37E, R57K, Q61N, L63V, I72T	B
	119929	119929	AY365975	PI	NA	M46I, N88S		I13V, I62V, L63P, A71AT, I72T, V77I, I93L	B
Machado (2004)	cs196	cs196	AY313360	NFV	93	M46I, N88S		L10I, T12S, I13V, L19I, K20I, E35D, N37H, R41K, K45R, L63P, V77I	B
Garcia-Bujalance (2005)	GBS_19	GBS_19	AY872300	NFV		N88S		T12P, K14R, E35D, N37D, L63P, I93L	B
	GBS_20	GBS_20	AY872301	IDV, NFV		N88S		L10V, I13V, I15IV, G16A, K20T, K45KR, I62V, I64V, V77I	B
Rhee (2005)	CA1317	CA7991	AY796611	IDV	36	N88S		I15V, K20T, E35D, M36I, R57K, L63P, I93IL	B
		CA12807	AY796612	IDV, SQV	85	N88S, L90M	L10F	I15V, K20T, E35D, M36I, R41K, R57K, I62V, L63P, C67CY, A71AT, I93L	B
	CA1405	CA9783	AY796654	IDV, NFV, SQV	151	M46ML, N88S		L63A, I72V, V77I	B
	CA1625	CA13280	AY796812	IDV, NFV	166	N88S	L10LF	L5LF, E34D, M36V, L63P, I93IL	B
		CA16541	AF544507	IDV, NFV	194	N88S		E34D, M36V, I62V, L63P, I93L	B
	CA1813	CA9691	AY796820	IDV, SQV, RTV	98	M46L, N88S, L90M		L10V, I13V, I15V, K20M, E35D, M36I, I62V, L63P, A71T, I93L	B
	CA4301	CA38056	AY797042	IDV, SQV, RTV, NFV, LPV, ATV	350	M46I, N88S		N37D, V77I	B
	SWC-6459	6459-2425		IDV, NFV	110	M46I, N88S		L19I, R41K, V77I, Q92X	B
		6459-4252		IDV, NFV	212	M46I, N88S		L19I, R41K, V77I	B
	ASRU006	ASRU006		SQV, NFV	91	N88S		L10V, I13V, K14R, I15V, K20I, M36I	B
	CA4870	CA21287	AY797182	IDV	157	M46I, N88S		L10IV, I13V, K14KR, R41K, Q61H, L63P, A71AT, T74TS, I93L	B
	CA5205	CA16120	AY797265	IDV, NFV, SQV, RTV	171	M46I, N88S		L10I, I13V, K20I, L63P, I64V, I93L	B
	CA5551	CA37827	AY797347	NFV, RTV	241	M46I, N88S, L90LM	Q58E	K20L, I62V, L63P, A71T, T74S, V77I	B
	CA6804	CA20598	AY797448	IDV, NFV	183	M46I, N88S		L10IV, I62V, L63P, T74TS, V77I, Q92R, I93L	B
	CA7087	CA17577	AY797510	NFV	175	N88S	Q58E	L10V, I13V, K20I, M46X, I62V, L63P, V77I	B
	CA7931	CA20391	AY797597	NFV	80	N88S	L10F	I13V, K20T, E35D, M36IL, R41K, I62V, L63LP, I64V	B
	CA8010	CA33719	AY797643	NFV	104	M46MI, N88S	L10LF, Q58QE	K45KR, R57RK, L63P, V77I, I93IL	B
		CA37781	AY797644	NFV	142	M46MI, N88S	L10F, Q58QE	K45KR, R57RK, L63P, V77I, I93L	B
	CA8385	CA21332	AY797728	IDV, NFV	164	D30DN, N88S		I15IV, L63P, V77I	B
	CA9937	CA24568	AY797943	IDV	134	M46I, N88S		I13V, N37T, I62V, L63P, I64IL, V77I, I93L	B
	CA14345	CA33559	AY798052	SQV, IDV, NFV	304	N88S	L23LI, L33F	I13V, N37S, P39S, D60E, A71V, V77I	B
	CA14581	CA33959	AY798124	NFV	189	N88S		L10I, I13V, K20R, E35D, M36I, D60E, Q61E, I62V, L63P, I72V, I93L	B
	CA14642	CA34049	AY798134	IDV, NFV	169	N88S	M46MV	L10I, Q18H, E35D, N37S, R41K, L63P, I72V, I93L	B
	CA18429	CA43005	AY798305	NFV	180	N88S	L10F	T12P, K14R, I15V, G16E, K20T, R57RK, I62V, L63N, V77I	B
Baxter (2006)	12-2275	2275-30725	DQ876026	PI	NA	M46I, I84V, N88S	L10F, L33F	I13V, L19V, K20T, R57K, L63P, A71T, V77I	B
	12-2107	2107-30626	DQ876434	PI	NA	M46I, I54IL, N88S	L10F, Q58E	I13V, M36MI, N37E, I62IV, L63S, V77I, L89M, I93L	B
	48-1438	1438-30513	DQ877828	PI	NA	M46I, N88S		L10I, I15V, K20T, E35D, L63P, I93L	B
	48-2211	2211-30526	DQ877864	PI	NA	I54M, N88S, L90M		L10I, K14R, I15V, L19T, K20T, E34EQ, E35DN, M36I, N37S, L63LP, A71I, G73GD, T74S, V77I, I85V, Q92K, I93L	B
	48-7125	7125-30902	DQ878968	PI	NA	M46L, N88S	L33LF	L10I, T12TK, I13V, K14KR, I15V, K20I, R41K, L63P, A71T, I93L	B
	48-9230	9230-30915	DQ877640	PI	NA	M46I, I84V, N88S		L10I, I13V, L19V, K20I, E35ED, N37S, L63P, I66IV, A71T, I72IT, I85IV, I93L	B
Rhee (2006)	CA8384	CA21331	DQ316712	IDV, RTV	171	N88S, L90M	Q58E	L10I, I15V, K20T, E35D, M36I, I62V, L63P, A71T, I85IV	B
von Wyl (2007)	115	732708	EF449791	PI	NA	N88S, L90LM	M46MV	L10LI, T12A, K14R, I15V, Q18I, K20T, R41K, L63P, V77I	B
	97	5247096	EF449924	PI	NA	M46L, N88S, L90M		K14R, E35D, M36V, R41K, I62V, L63P, G68E, A71V, I93L, L97F, N98K	B
	108	1435942	EF449983	PI	NA	N88S	L10F	V77I, I93L	B
Zolopa (2007)	3	AZ_3		ATV	24	N88S		T12K, L19V, K20KT, E34EQ, E35D, M36MV, N37X, R41K, K45R, R57K, L63P, I64L, A71T, V77I, I93L	B
Dumans (2009)	PA262	PA262	DQ659460	SQV, IDV	26	N88S		N37T, R41K, H69K	B
Rhee (2009)	CA8468	CA21458	FJ983301	NFV	175	N88S		I15IV, K20KM, E35D, M36IV, R41K, I62V, L63HQ, A71V, I72T, I93L	B
	CA9642	CA23540	FJ983309	IDV, NFV	215	N88S		L10I, M36I, K45KR, R57K, L63P, I93L	B
	CA14266	CA33433	FJ983355	IDV, NFV, SQV, RTV	215	M46I, N88S, L90M	F53FL	L10I, I13V, K14R, N37D, L63P, A71IT, I72X, V77VI, I93L	B
Dau (2010)	08710A	08710A	GU581939	PI	NA	N88S		I15V, N37E, L63V, K70R	B
	10962A	10962A	GU582026	PI	NA	M46MI, N88S	L23I	L10I, I13V, L63P, I64IM, V77I, I93L	B
	11056A	11056A	GU582031	PI	NA	M46I, N88S		I13V, R57K, L63P, V77I	B
Jones (2012)	137172	137172	JN669560	PI	NA	N88S	L10F, L33I	I13V, M36L, I62V, L63P	B
	147928	147928	JN669704	PI	NA	N88S		K20MR, E35D, M36I, N37D, R41RK, K43KR, K45KR, I62IV, L63P, H69K, I93L	B
	152323	152323	JN669777	PI	NA	M46I, N88S		T12N, L19I, R41K, L63P, V77I, I93L	B
	154205	154205	JN669812	PI	NA	M46I, N88S		L63S, V77I	B
	156694	156694	JN669872	PI	NA	M46ML, N88S		L10I, N37S, R41K, L63P, I93L	B
	156863	156863	JN669875	PI	NA	M46MI, I50IL, N88S		L10I, T12PS, L19T, K20LM, E21EQ, L33LV, K45R, R57RK, L63P, A71T, I85V, I93L	B
	181264	181264	JN670572	PI	NA	M46I, N88S	L89V	L10I, I13V, K14R, I62V, L63P, Q92K, I93L	B
	194994	194994	JN670958	PI	NA	I50L, N88S	L33F	I13IV, L19V, E34EQ, N37S, R41K, K45R, L63P, A71I, V77VI, I93L	B
	196066	196066	JN671011	PI	NA	N88S		L10I, T12K, I15V, L19M, K20T, E35D, M36I, R41K, R57K, Q61N, A71T	B

Protease Inhibitors

Database

Resources

Team