<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation N83D
Rx >= 1 PI
IncludeMixtures No
References 11
Patients 48
Isolates 57
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Rousseau (2000)MNR10MNR4415AJ405955SQV, IDV, NFV, RTV, Unknown>142M46I, I84V, L90MN83DL10I, E35D, M36I, N37D, R41K, R57K, I62V, L63P, I64V, A71V, I93LB
Gonzales (2001)CA1624CA4605AY030712IDV, SQV, RTV136I54IVL24I, L33F, F53L, G73CS, N83DI15V, E34Q, M36L, N37S, L38W, R57K, D60DE, I62V, L63P, A71VB
 CA1886CA5087AY030777SQV, NFV139D30NN83DI13V, E35D, M36I, N37T, L63PB
 CA4140CA9987AY031119IDV, NFV125V32I, M46I, L90LML33F, K43T, N83DL10N, I13V, M36L, N37S, P39Q, R41K, K55R, I62V, L63P, I64VB
 CA5239CA12913AY031796IDV, NFV186L90MN83DW6WL, L19I, E35G, M36I, N37E, D60E, I62V, L63P, I64V, I93LB
Romano (2002)MZ-pt19pt19-t0AF493354SQV, NFV, IDV, RTV M46I, I84V, L90ML10F, L33I, G73S, N83DA22V, E35G, M36I, R41K, I62V, L63P, A71V, I72L, I85VB
Shafer (2003)A384_09010901bEF548333NFV15I54V, I84V, L90MN83DL10I, K20R, E35D, M36I, N37D, I62V, L63P, A71VB
  0901cEF548334NFV16I54V, I84V, L90MN83DL10I, K20R, E35D, M36I, N37D, I62V, L63P, A71VB
  0901d NFV, RTV, APV160I54L, I84V, L90ML33F, N83DL10I, K20R, E35N, M36L, N37D, I62V, L63P, A71V, L89IB
Wu (2003)CA1624CA17101AF544506IDV, SQV, RTV, NFV, APV209I54IL, I84IVL24I, L33F, F53L, G73C, N83DI15V, A22AV, E34Q, M36L, L38W, P39S, R57K, D60E, I62V, L63P, A71VB
 CA6800CA21370AF544598SQV, RTV, APV, IDV, LPV221M46L, I84VL33F, N83DT4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89IB
 CA9428CA23148AF544617RTV, NFV, LPV199I54V, V82AL24I, L33F, K43T, F53L, N83DL10I, I13V, K20R, M36I, D60E, I62V, L63P, I64VB
Gomez-Carrillo (2004)9937699376AY365598PINAV32I, I54V, L90ML33F, N83DL10I, I13V, K14R, M36V, N37S, R41K, L63Q, I64V, A71VB
 104668104668AY365710PINAI54V, V82SL33F, F53FL, N83DL10I, I13V, K14R, M36L, N37D, I62V, L63P, I64V, T74ASB
Rhee (2005)CA1624CA11023AY796811IDV, SQV, RTV157I54VL24I, L33F, F53L, G73C, N83DI15V, E34Q, M36L, N37NS, L38W, P39PS, R57K, D60E, I62V, L63P, A71VB
 CA6800CA21302AY797446SQV, RTV, APV, IDV, LPV217M46L, I84VL33F, N83DT4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89IB
 CA7108CA41294AY797531IDV, NFV, Unknown, LPV>207M46I, I84V, L90ML10F, G73T, N83DK20R, E34Q, M36I, R41K, I62V, L63P, I64V, I93LB
 CA7982CA20462AY797623IDV, SQV, RTV, APV195I54L, I84V, L90ML10F, L33LF, N83DR8Q, T12S, K20R, E34K, E35D, M36I, R41K, I62V, L63P, A71VB
Baxter (2006)12-22992299-30818DQ876048PINAV32I, M46I, L90ML10F, V11I, L33F, G73S, N83DT12S, I13V, L19I, E34V, M36L, N37ND, I62V, L63P, A71VB
 12-16781678-30331DQ876270PINAM46I, I54V, I84V, L90ML33F, Q58E, N83DL10I, I13V, M36L, I62V, L63P, I64V, L89MB
 12-20912091-30711DQ876411PINAM46L, I54A, V82AL24I, L33F, K43T, N83DL10I, I13V, K20KR, M36L, N37D, Q61QHKN, I62V, L63Q, I64V, I72IV, T74ASB
 12-10811081-30417DQ876421PINAM46I, I84VN83DL10I, I13V, G16A, K20R, A22V, E35D, M36I, I62V, L63P, A71TB
 12-12851285-30311DQ876614PINAM46I, I54L, L76V, I84V, L90MN83DL10I, K20R, E34Q, M36D_*, R41K, D60E, I62V, L63P, A71V, I93LB
 12-23842384-30815DQ876642PINAM46I, I84VL10F, N83D, N88DI13V, G16A, A22V, E34Q, N37ND, R57K, L63P, A71V, T91AB
 12-21362136-30821DQ876744PINAM46L, I54V, I84V, L90ML10F, L33F, N83DK20R, E35D, M36L, R41K, K45V, K55Q, I62V, L63P, I64VB
 12-15021502-30604DQ876900PINAM46L, I54A, V82AL24I, L33F, K43T, N83DL10I, I13V, K20KR, M36L, N37D, Q61QHKN, I62V, L63Q, I64V, I72IV, T74ASB
 12-11811181-30507DQ876950PINAI54V, V82AL24I, L33F, F53L, N83DL10I, I13V, K14R, E35D, M36L, R41K, K55KR, I62IV, L63P, A71VB
 12-11931193-30305DQ876960PINAI54A, V82AL33F, I47IK, N83DL10I, I13V, K20R, M36L, R41N, K45I, D60E, I62V, L63P, I64VB
 12-31483148-30506DQ877158PINAV32I, M46I, I54V, V82AL33I, F53L, N83DL10I, I13V, K14M, K20R, M36I, N37D, L63P, I64V, A71V, T91SB
 12-30603060-30415DQ877165PINAM46I, I84V, L90ML10F, L33F, N83D, N88DT4S, I13V, G16A, L19I, L24L*, E35N, M36I, P39S, I62V, L63P, A71V, I72VB
 48-12591259-31208DQ877787PI, RTV, TPV>25I54V, I84V, L90MN83DL10I, E34Q, M36L, N37D, L38W, R57K, I62V, L63P, A71V, I93LB
  1259-40720DQ877786PI, RTV, TPV>57I54V, I84V, L90MN83DL10I, T31TA, E34Q, M36L, N37D, L38W, R57K, I62V, L63P, A71V, I93LB
 48-14331433-30220DQ877823PINAM46I, I54V, I84V, L90MQ58E, N83DL10I, T12N, I13A, K14KI, L19M, K20R, A22V, M36I, R41RK, K55R, R57K, I62V, L63P, I64V, I66V, H69R, T74S, Q92K, I93L, C95FB
 48-31273127-30401DQ878035PINAM46L, G48GA, I54V, V82A, L90ML33F, K43T, N83DT4TS, L10I, T12P, L19EV, K20R, M36L, N37D, K55KR, R57K, I62V, L63P, A71V, T91TS, Q92KB
 48-32093209-30519DQ878119PINAI54V, V82AL24I, L33F, K43T, F53L, N83DL10I, L19I, K20R, E35D, M36L, N37D, R41K, R57K, I62V, L63P, A71VB
 48-40464046-30408DQ878278PINAM46I, I54V, I84VL10F, L33F, K43T, N83DT4A, T12P, I13V, K14R, A22V, E34R, M36A, P39Q, D60E, I62V, L63P, H69Y, A71V, T91AS, Q92K, I93LB
  4046-40304DQ878279PI, RTV, TPV>47M46I, I54V, I84VL33F, K43T, N83DT4A, T12P, I13V, K14R, A22V, E34R, M36A, P39Q, D60E, I62V, L63P, H69Y, A71V, T91AS, Q92K, I93LB
 48-40584058-30311DQ878290PINAM46I, I54V, I84VL24I, Q58E, N83DL10I, I13IV, K20R, A22V, E35D, M36I, N37Q, I62V, L63P, I64V, A71V, I72V, T91S, I93LB
 48-41084108-30304DQ878338PINAV32I, M46I, I47V, I54M, L90ML33F, F53L, N83DL10I, T12P, I15IV, E34Q, R41K, I62V, L63P, C67W, A71I, I72V, G73D, V77I, V82I, Q92K, I93LB
 48-41404140-30424DQ878372PINAM46I, I54V, I84V, L90ML10FI, L33LI, N83D, L89VV11VL, I13V, K20R, A22V, E34A, E35D, M36I, N37D, I62V, L63P, A71I, I72L, T91TCS, Q92K, I93LB
 48-42014201-30724DQ878433PINAM46I, I54V, V82A, I84V, L90MN83DL10I, T12P, K14R, K20R, E34R, M36I, N37S, R41K, I62V, L63P, H69HY, A71AT, I72EV, I93LB
 48-50115011-31014DQ878546PI, RTV, TPV>22M46I, I54V, I84VV11I, L24I, N83DI13V, K20R, A22V, E35D, M36I, K55R, R57K, Q61E, I62V, L63P, A71T, I72V, T91TCSB
  5011-40722DQ878545PI, RTV, TPV>63M46I, I47V, I54V, I84VV11I, N83DL10I, I13V, K20R, A22V, L24M, E35D, M36I, K55KR, R57K, Q61E, I62V, L63P, A71T, I72V, T91SB
 48-61666166-30729DQ878742PINAI54V, I84V, L90MV11VI, L33I, G73GS, N83D, L89VL10I, I13V, L19LV, K20R, A22V, E35D, M36I, N37E, I62IV, L63P, A71AITV, Q92QKB
 48-63296329-30924DQ878862PINAI54IL, I84VL33I, N83DL10IV, T12IV, I13AV, A22V, E35D, M36I, Q61HN, I62V, L63Q, I64V, A71AT, I72IT, T74S, V75VI, T91TSB
 48-63446344-30918DQ878867PINAM46I, I47IV, I54IL, L76LV, I84V, L90ML10FI, L33I, N83D, L89VI13V, Q18H, A22V, E35N, M36I, N37D, R41RK, K55KR, I62V, L63P, A71VB
 48-90719071-30901DQ877285PINAM46I, I47V, I54V, V82A, L90ML33F, F53L, Q58E, N83DL10V, G16A, K20R, E35D, M36I, N37D, R57K, D60E, Q61N, L63P, L89IB
 48-91849184-30901DQ877532PINAM46L, I54V, V82A, L90ML33F, K43T, F53L, N83DL10I, I13V, K20R, M36L, N37T, K55KR, R57RK, D60DE, I62V, L63P, I64V, L89LMB
 48-90889088-30827DQ877659PINAG48V, I54V, V82AL33F, K43KT, F53L, N83DL10I, I13V, L19I, K20R, E35D, M36I, N37C, R57K, I62V, L63Q, I64V, C67Y, I72V, V75I, T91TAB
De Meyer (2009)DRV01DRV01-48w PI, DRV, RTV>48V32I, M46I, I47V, I54M, I84VL10F, V11I, L24I, L33F, Q58E, N83DI13V, G16E, M36I, L63P, I64VB
 DRV02DRV02BL PINAV32I, M46I, I84V, L90ML33F, N83DL10I, I13V, M36L, I62V, I64VB
  DRV02-48w PI, DRV, RTV>48V32I, M46I, L76V, I84V, L90ML33F, N83DL10I, I13V, M36L, I62V, I64VB
Dau (2010)08383A08383AGU581908PINAM46I, I54V, I84VL24I, N83D, L89VL10I, I13V, K14KN, L19Q, A22V, M36L, N37D, D60E, I62V, L63P, A71V, I72T, T91TS, Q92KB
 10604A10604AGU582013PINAV32I, M46I, I84VL33F, F53L, N83DL10V, I13V, E34EQ, E35D, M36L, N37D, L63LP, I64V, A71AV, G73GV, T74SB
Jones (2012)156312156312JN669860PINAM46MI, I47V, G48A, I54V, V82AL24I, L33F, K43T, N83DL10I, K20R, M36L, N37S, R41K, D60E, I62V, L63P, I64V, A71T, T91SB
 175671175671JN670367PINAG48M, I84VN83DI13V, E35D, M36I, R57K, I62V, I64V, T74SB
 207115207115JN671422PINAV32I, L90ML33F, M46MV, F53L, N83D, L89VL10I, I13V, M36V, N37S, R41K, I62IV, L63Q, A71VB