<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation N83D
Rx >= 1 PI
IncludeMixtures No
References 12
Patients 96
Isolates 105
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Rousseau (2000)MNR10MNR4415AJ405955SQV, IDV, NFV, RTV, Unknown>142M46I, I84V, L90MN83DL10I, E35D, M36I, N37D, R41K, R57K, I62V, L63P, I64V, A71V, I93LB
Gonzales (2001)CA1624CA4605AY030712IDV, SQV, RTV136I54IVL24I, L33F, F53L, G73CS, N83DI15V, E34Q, M36L, N37S, L38W, R57K, D60DE, I62V, L63P, A71VB
 CA1886CA5087AY030777SQV, NFV139D30NN83DI13V, E35D, M36I, N37T, L63PB
 CA4140CA9987AY031119IDV, NFV125V32I, M46I, L90LML33F, K43T, N83DL10N, I13V, M36L, N37S, P39Q, R41K, K55R, I62V, L63P, I64VB
 CA5239CA12913AY031796IDV, NFV186L90MN83DW6WL, L19I, E35G, M36I, N37E, D60E, I62V, L63P, I64V, I93LB
Romano (2002)MZ-pt19pt19-t0AF493354SQV, NFV, IDV, RTV M46I, I84V, L90ML10F, L33I, G73S, N83DA22V, E35G, M36I, R41K, I62V, L63P, A71V, I72L, I85VB
Shafer (2003)A384_09010901bEF548333NFV15I54V, I84V, L90MN83DL10I, K20R, E35D, M36I, N37D, I62V, L63P, A71VB
  0901cEF548334NFV16I54V, I84V, L90MN83DL10I, K20R, E35D, M36I, N37D, I62V, L63P, A71VB
  0901d NFV, RTV, APV160I54L, I84V, L90ML33F, N83DL10I, K20R, E35N, M36L, N37D, I62V, L63P, A71V, L89IB
Wu (2003)CA1624CA17101AF544506IDV, SQV, RTV, NFV, APV209I54IL, I84IVL24I, L33F, F53L, G73C, N83DI15V, A22AV, E34Q, M36L, L38W, P39S, R57K, D60E, I62V, L63P, A71VB
 CA6800CA21370AF544598SQV, RTV, APV, IDV, LPV221M46L, I84VL33F, N83DT4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89IB
 CA9428CA23148AF544617RTV, NFV, LPV199I54V, V82AL24I, L33F, K43T, F53L, N83DL10I, I13V, K20R, M36I, D60E, I62V, L63P, I64VB
Gomez-Carrillo (2004)9937699376AY365598PINAV32I, I54V, L90ML33F, N83DL10I, I13V, K14R, M36V, N37S, R41K, L63Q, I64V, A71VB
 104668104668AY365710PINAI54V, V82SL33F, F53FL, N83DL10I, I13V, K14R, M36L, N37D, I62V, L63P, I64V, T74ASB
Rhee (2005)CA1624CA11023AY796811IDV, SQV, RTV157I54VL24I, L33F, F53L, G73C, N83DI15V, E34Q, M36L, N37NS, L38W, P39PS, R57K, D60E, I62V, L63P, A71VB
 CA6800CA21302AY797446SQV, RTV, APV, IDV, LPV217M46L, I84VL33F, N83DT4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89IB
 CA7108CA41294AY797531IDV, NFV, Unknown, LPV>207M46I, I84V, L90ML10F, G73T, N83DK20R, E34Q, M36I, R41K, I62V, L63P, I64V, I93LB
 CA7982CA20462AY797623IDV, SQV, RTV, APV195I54L, I84V, L90ML10F, L33LF, N83DR8Q, T12S, K20R, E34K, E35D, M36I, R41K, I62V, L63P, A71VB
Baxter (2006)12-22992299-30818DQ876048PINAV32I, M46I, L90ML10F, V11I, L33F, G73S, N83DT12S, I13V, L19I, E34V, M36L, N37ND, I62V, L63P, A71VB
 12-16781678-30331DQ876270PINAM46I, I54V, I84V, L90ML33F, Q58E, N83DL10I, I13V, M36L, I62V, L63P, I64V, L89MB
 12-20912091-30711DQ876411PINAM46L, I54A, V82AL24I, L33F, K43T, N83DL10I, I13V, K20KR, M36L, N37D, Q61QHKN, I62V, L63Q, I64V, I72IV, T74ASB
 12-10811081-30417DQ876421PINAM46I, I84VN83DL10I, I13V, G16A, K20R, A22V, E35D, M36I, I62V, L63P, A71TB
 12-12851285-30311DQ876614PINAM46I, I54L, L76V, I84V, L90MN83DL10I, K20R, E34Q, M36D_*, R41K, D60E, I62V, L63P, A71V, I93LB
 12-23842384-30815DQ876642PINAM46I, I84VL10F, N83D, N88DI13V, G16A, A22V, E34Q, N37ND, R57K, L63P, A71V, T91AB
 12-21362136-30821DQ876744PINAM46L, I54V, I84V, L90ML10F, L33F, N83DK20R, E35D, M36L, R41K, K45V, K55Q, I62V, L63P, I64VB
 12-15021502-30604DQ876900PINAM46L, I54A, V82AL24I, L33F, K43T, N83DL10I, I13V, K20KR, M36L, N37D, Q61QHKN, I62V, L63Q, I64V, I72IV, T74ASB
 12-11811181-30507DQ876950PINAI54V, V82AL24I, L33F, F53L, N83DL10I, I13V, K14R, E35D, M36L, R41K, K55KR, I62IV, L63P, A71VB
 12-11931193-30305DQ876960PINAI54A, V82AL33F, I47IK, N83DL10I, I13V, K20R, M36L, R41N, K45I, D60E, I62V, L63P, I64VB
 12-31483148-30506DQ877158PINAV32I, M46I, I54V, V82AL33I, F53L, N83DL10I, I13V, K14M, K20R, M36I, N37D, L63P, I64V, A71V, T91SB
 12-30603060-30415DQ877165PINAM46I, I84V, L90ML10F, L33F, N83D, N88DT4S, I13V, G16A, L19I, L24L*, E35N, M36I, P39S, I62V, L63P, A71V, I72VB
 48-12591259-31208DQ877787PI, RTV, TPV>25I54V, I84V, L90MN83DL10I, E34Q, M36L, N37D, L38W, R57K, I62V, L63P, A71V, I93LB
  1259-40720DQ877786PI, RTV, TPV>57I54V, I84V, L90MN83DL10I, T31TA, E34Q, M36L, N37D, L38W, R57K, I62V, L63P, A71V, I93LB
 48-14331433-30220DQ877823PINAM46I, I54V, I84V, L90MQ58E, N83DL10I, T12N, I13A, K14KI, L19M, K20R, A22V, M36I, R41RK, K55R, R57K, I62V, L63P, I64V, I66V, H69R, T74S, Q92K, I93L, C95FB
 48-31273127-30401DQ878035PINAM46L, G48GA, I54V, V82A, L90ML33F, K43T, N83DT4TS, L10I, T12P, L19EV, K20R, M36L, N37D, K55KR, R57K, I62V, L63P, A71V, T91TS, Q92KB
 48-32093209-30519DQ878119PINAI54V, V82AL24I, L33F, K43T, F53L, N83DL10I, L19I, K20R, E35D, M36L, N37D, R41K, R57K, I62V, L63P, A71VB
 48-40464046-30408DQ878278PINAM46I, I54V, I84VL10F, L33F, K43T, N83DT4A, T12P, I13V, K14R, A22V, E34R, M36A, P39Q, D60E, I62V, L63P, H69Y, A71V, T91AS, Q92K, I93LB
  4046-40304DQ878279PI, RTV, TPV>47M46I, I54V, I84VL33F, K43T, N83DT4A, T12P, I13V, K14R, A22V, E34R, M36A, P39Q, D60E, I62V, L63P, H69Y, A71V, T91AS, Q92K, I93LB
 48-40584058-30311DQ878290PINAM46I, I54V, I84VL24I, Q58E, N83DL10I, I13IV, K20R, A22V, E35D, M36I, N37Q, I62V, L63P, I64V, A71V, I72V, T91S, I93LB
 48-41084108-30304DQ878338PINAV32I, M46I, I47V, I54M, L90ML33F, F53L, N83DL10I, T12P, I15IV, E34Q, R41K, I62V, L63P, C67W, A71I, I72V, G73D, V77I, V82I, Q92K, I93LB
 48-41404140-30424DQ878372PINAM46I, I54V, I84V, L90ML10FI, L33LI, N83D, L89VV11VL, I13V, K20R, A22V, E34A, E35D, M36I, N37D, I62V, L63P, A71I, I72L, T91TCS, Q92K, I93LB
 48-42014201-30724DQ878433PINAM46I, I54V, V82A, I84V, L90MN83DL10I, T12P, K14R, K20R, E34R, M36I, N37S, R41K, I62V, L63P, H69HY, A71AT, I72EV, I93LB
 48-50115011-31014DQ878546PI, RTV, TPV>22M46I, I54V, I84VV11I, L24I, N83DI13V, K20R, A22V, E35D, M36I, K55R, R57K, Q61E, I62V, L63P, A71T, I72V, T91TCSB
  5011-40722DQ878545PI, RTV, TPV>63M46I, I47V, I54V, I84VV11I, N83DL10I, I13V, K20R, A22V, L24M, E35D, M36I, K55KR, R57K, Q61E, I62V, L63P, A71T, I72V, T91SB
 48-61666166-30729DQ878742PINAI54V, I84V, L90MV11VI, L33I, G73GS, N83D, L89VL10I, I13V, L19LV, K20R, A22V, E35D, M36I, N37E, I62IV, L63P, A71AITV, Q92QKB
 48-63296329-30924DQ878862PINAI54IL, I84VL33I, N83DL10IV, T12IV, I13AV, A22V, E35D, M36I, Q61HN, I62V, L63Q, I64V, A71AT, I72IT, T74S, V75VI, T91TSB
 48-63446344-30918DQ878867PINAM46I, I47IV, I54IL, L76LV, I84V, L90ML10FI, L33I, N83D, L89VI13V, Q18H, A22V, E35N, M36I, N37D, R41RK, K55KR, I62V, L63P, A71VB
 48-90719071-30901DQ877285PINAM46I, I47V, I54V, V82A, L90ML33F, F53L, Q58E, N83DL10V, G16A, K20R, E35D, M36I, N37D, R57K, D60E, Q61N, L63P, L89IB
 48-91849184-30901DQ877532PINAM46L, I54V, V82A, L90ML33F, K43T, F53L, N83DL10I, I13V, K20R, M36L, N37T, K55KR, R57RK, D60DE, I62V, L63P, I64V, L89LMB
 48-90889088-30827DQ877659PINAG48V, I54V, V82AL33F, K43KT, F53L, N83DL10I, I13V, L19I, K20R, E35D, M36I, N37C, R57K, I62V, L63Q, I64V, C67Y, I72V, V75I, T91TAB
De Meyer (2009)DRV01DRV01-48w PI, DRV, RTV>48V32I, M46I, I47V, I54M, I84VL10F, V11I, L24I, L33F, Q58E, N83DI13V, G16E, M36I, L63P, I64VB
 DRV02DRV02BL PINAV32I, M46I, I84V, L90ML33F, N83DL10I, I13V, M36L, I62V, I64VB
  DRV02-48w PI, DRV, RTV>48V32I, M46I, L76V, I84V, L90ML33F, N83DL10I, I13V, M36L, I62V, I64VB
Dau (2010)08383A08383AGU581908PINAM46I, I54V, I84VL24I, N83D, L89VL10I, I13V, K14KN, L19Q, A22V, M36L, N37D, D60E, I62V, L63P, A71V, I72T, T91TS, Q92KB
 10604A10604AGU582013PINAV32I, M46I, I84VL33F, F53L, N83DL10V, I13V, E34EQ, E35D, M36L, N37D, L63LP, I64V, A71AV, G73GV, T74SB
Jones (2012)156312156312JN669860PINAM46MI, I47V, G48A, I54V, V82AL24I, L33F, K43T, N83DL10I, K20R, M36L, N37S, R41K, D60E, I62V, L63P, I64V, A71T, T91SB
 175671175671JN670367PINAG48M, I84VN83DI13V, E35D, M36I, R57K, I62V, I64V, T74SB
 207115207115JN671422PINAV32I, L90ML33F, M46MV, F53L, N83D, L89VL10I, I13V, M36V, N37S, R41K, I62IV, L63Q, A71VB
Diaz (2015)RenG16129RenG16129KT747157PINAD30N, M46I, I54V, V82AL10F, L33F, N83D, N88DT4S, I13V, M36L, K45R, I62V, L63P, I64V, A71V, Q92KB
 RenG16218RenG16218KT747246PINAN88SL33F, N83D, L89LVI13V, I15V, M36L, R41K, H69R, A71AVB
 RenG15977RenG15977KT747005PINAM46L, I54V, V82AL24I, L33F, N83DL10V, I13V, I15V, Q18H, L19I, M36L, N37D, K55R, I62V, L63P, I64IVB
 RenG15558RenG15558KT746586PINAD30N, M46L, I54V, V82AL10F, L33I, K43T, F53L, N83D, N88DI13V, E21K, A22V, E35D, M36L, N37Q, R41K, Q61N, L63P, A71V, T74S, V75I, Q92KB
 RenG15598RenG15598KT746626PINAG48Q, I84VL33I, G73S, N83D, L89VL10I, I13V, A22V, E35D, M36I, N37E, K43E, D60E, Q61N, I62V, L63P, A71T, I72R, I93LB
 RenG15567RenG15567KT746595PINAI50LQ58E, N83DI13V, K20R, E34K, M36I, R41K, D60E, I62V, L63P, H69Y, A71T, I72EB
 RenG15842RenG15842KT746870PINAV32I, I47V, I54M, L90ML10F, L33I, N83D, L89VI13V, E35N, M36I, N37S, R41K, R57K, L63P, A71TB
 RenG17051RenG17051KT748079PINAD30N, M46I, I50LL10F, L33F, N83D, N88DE34Q, M36V, R41K, I62V, L63P, A71V, T74SB
 RenG15662RenG15662KT746690PINAI50L, L90ML33F, Q58E, G73S, N83DI13EGKR, I15V, E34Q, M36L, N37NS, P39PS, I62V, L63P, A71VB
 RenG16990RenG16990KT748018PINAV32I, M46I, I47VL10F, N83DA22V, M36MIV, N37S, R41K, I62IV, L63P, I64V, A71V, I93LB
 RenG15288RenG15288KT746316PINAM46I, I54V, V82AV11I, L24I, L33F, F53L, N83DL10I, I15V, L19I, K20KR, M36L, N37D, L38W, K55R, R57K, I62V, L63P, G68DE, A71I, I72IV, I93LB
 RenG15490RenG15490KT746518PINAI50LL33F, K43T, N83DR8H, L10X, M36L, N37S, I62V, L63E, I64V, E65DB
 RenG14345RenG14345KT745373PINAD30N, M46I, I47AF53L, G73GS, N83D, N88DL10I, K20R, A22V, E34D, E35N, M36I, N37E, R41K, Q61QH, I62V, L63P, A71V, I72KT, I85V, I93LB
 RenG15476RenG15476KT746504PINAD30N, I54LL33F, G73GS, N83D, N88DL10Y, E35D, M36L, N37D, K43R, R57K, Q61N, L63P, A71V, T74S, I93LB
 RenG13921RenG13921KT744949PINAM46I, G48M, I54V, L76V, V82A, I84VL33F, N83DL10IV, I13V, K20R, E35ED, M36I, N37EK, R41P, R57K, Y59YF, Q61N, L63P, L89IM, I93N, T96XB
 RenG13742RenG13742KT744770PINAM46ML, G48A, I54V, V82AL24I, L33F, K43KT, N83DL10I, I13V, K14KR, M36L, N37S, D60E, I62V, L63P, I64IV, I72IMVB
 RenG14992RenG14992KT746020PINAI50LL33F, F53FL, Q58E, N83DL10V, I13V, I15V, E34Q, M36L, N37S, R57K, I64V, H69Y, A71ATB
 RenG14984RenG14984KT746012PINAD30N, I84VL10F, L33LI, N83D, N88DI13V, L19I, K20KR, E34EQ, E35DN, M36I, N37S, L63P, A71IT, T74S, I93LB
 RenG14836RenG14836KT745864PINAM46L, G48M, I54S, V82AL33F, Q58E, N83DL10I, I13V, M36L, K55KR, R57RK, Q61N, I62V, L63T, I64IV, I72IATVB
 RenG15483RenG15483KT746511PINAM46I, I84VL10F, L33I, N83D, L89VI13V, K20R, A22V, M36I, R57K, I62V, L63P, A71T, T91SB
 RenG14340RenG14340KT745368PINAI50LL33F, N83DI13V, I15V, M36L, N37T, K45I, Q61E, I62V, I64VB
 RenG15354RenG15354KT746382PINAD30N, M46I, I54L, V82AL10F, L33F, N83DI13V, I15V, Q18I, M36L, N37D, R41K, L63P, A71V, L89I, Q92KB
 RenG15315RenG15315KT746343PINAD30N, I50LL10F, L33I, N83D, N88DI13V, A22V, E35D, M36I, N37S, K45R, I62IV, L63P, A71V, N98NIB
 RenG15328RenG15328KT746356PINAM46L, I50L, V82AL24I, L33F, Q58E, N83DL10LI, I13V, I15V, E34Q, M36V, P39Q, R41K, D60E, L63P, I64V, A71V, I93LB
 RenG15100RenG15100KT746128PINAM46I, I50V, I54V, V82AL33F, K43T, T74P, N83DL10I, I13V, K20R, E35D, M36I, R41K, K55R, R57K, D60E, Q61D, I62V, L63P, L89IB
 RenG15116RenG15116KT746144PINAV32I, M46I, I47V, I50V, I54V, V82VA, L90ML10F, L33F, Q58E, N83DI13V, I15V, E34Q, M36L, R41K, K55R, R57K, D60E, I62V, L63P, T74A, I85IV, L89MB
 RenG15436RenG15436KT746464PINAV32I, I47V, I54L, V82M, L90ML33F, K43T, N83DL10I, K20R, E35N, M36L, N37S, R57K, I62V, L63P, A71I, V77I, Q92KB
 RenG14732RenG14732KT745760PINAV32I, M46I, I47V, L90ML33LI, G73S, N83DL10I, L19I, E35DN, M36I, N37D, I62V, L63P, A71V, I93LB
 RenG12719RenG12719KT743747PINAV32I, I47V, I84VL33F, M46V, N83D, L89VL10R, I13V, K20KR, E35D, M36L, Q61HY, L63P, G68GE, A71T, T91SB
 RenG12824RenG12824KT743852PINAD30N, M46L, I54V, V82AL33I, F53L, N83D, N88DL10I, I13V, G16E, K20R, A22V, E35N, M36I, N37T, K45R, R57K, Q61N, L63T, E65D, A71V, I72T, T74S, V75I, L89M, Q92KB
 RenG12175RenG12175KT743203PINAG48Q, I54L, I84VL33F, K43KT, F53L, N83DL10I, T12I, I13V, E35D, M36I, N37D, R41K, R57K, Q61N, L63V, I64V, A71V, I93LB
 RenG13143RenG13143KT744171PINAV32I, M46I, I47V, I54M, V82A, I84V, L90ML33F, K43T, G73GCFV, N83D, L89VL10I, I13V, I15V, K20R, E35D, M36I, N37E, K55R, L63P, A71V, I72VB
 RenG13312RenG13312KT744340PINAM46L, I84VL33F, N83DL10I, I15V, K20R, A22V, E34N, E35D, M36I, N37E, K55R, R57K, I62V, L63P, H69Q, A71TB
 RenG12933RenG12933KT743961PINAD30NF53L, N83D, N88DL10V, I13V, A22V, E35D, M36I, N37E, R57K, Q61N, I62V, L63P, I64V, A71V, T74S, V75IB
 RenG13348RenG13348KT744376PINAI54V, V82AL33I, K43T, F53L, N83DW6C, Q7K, L10I, I13V, K20KR, E35D, M36I, N37E, D60DE, I62V, L63EQ, I64V, A71T, I72VB
 RenG11877RenG11877KT742905PINAM46L, I54V, V82AL24I, L33F, N83DL10I, I15IV, K20R, E35D, M36I, N37E, R57K, I62V, L63P, I64V, A71T, T91SB
 RenG12524RenG12524KT743552PINAG48A, I54V, L76V, V82A, I84VV11VI, L24I, L33F, K43T, M46V, F53L, N83DL10Y, L19I, K20R, E35N, M36I, N37D, K55R, R57K, D60E, Q61N, I62V, L63P, H69Y, A71V, I72K, L89I, T91A, Q92KB
 RenG12528RenG12528KT743556PINAV32I, I84VL10F, L33F, K43KT, Q58QE, N83DT12N, L19I, E34KR, M36I, L63P, H69Q, K70R, A71VB
 RenG13083RenG13083KT744111PINAM46L, I54V, V82AL24I, L33F, Q58E, N83DL10I, T12K, L19I, K20R, M36L, N37E, K55R, R57K, D60E, I62V, L63P, I64V, E65D, K70R, I72V, T74S, V75IB
 RenG10370RenG10370KT741398PINAM46I, L76V, V82A, I84VL33F, K43T, N83DL10I, I13V, K20R, E35D, M36I, K55KR, R57K, I62V, L63P, L89MB
 RenG10189RenG10189KT741217PINAV32I, M46I, I47V, I54M, V82A, L90ML33F, K43KT, N83D, L89LVL10I, I13V, I15V, K20KR, E35ED, M36I, N37E, K55R, L63P, A71V, I72VB
 RenG11355RenG11355KT742383PINAM46I, I47V, I54V, V82A, L90ML33F, K43T, F53L, N83DL10V, I13V, K14R, K20R, M36L, R41K, I62V, L63P, I64VB
 RenG11539RenG11539KT742567PINAV32I, M46I, I47V, I54L, V82AL10FI, L33LF, N83DI13V, G16A, K20R, A22V, E35D, M36I, R41K, R57K, Q61N, I64V, A71V, T74S, T91S, I93LB
 RenG11634RenG11634KT742662PINAV32I, M46I, I47V, I84VL10F, N83DI13V, K20KR, A22V, E35D, M36L, N37NT, R57K, I62V, L63P, G68GD, A71V, I72IVB
 RenG11244RenG11244KT742272PINAM46I, G48M, I54V, L76V, V82A, I84VL33F, N83DL10I, I13V, K20R, E35D, M36I, N37E, R41K, R57K, Q61N, L63PB
 RenG11592RenG11592KT742620PINAM46L, G48A, I54V, V82AL33I, N83DL10I, T12P, I13V, K20R, M36I, N37T, R41K, R57K, I62V, L63V, I64V, A71T, T74A, T91AB
 RenG11550RenG11550KT742578PINAM46I, I50V, V82A, L90ML33F, F53L, Q58E, N83DI13V, I15V, E34EQ, E35D, M36L, N37S, R57K, I62V, L63P, A71V, L89IB
 RenG11799RenG11799KT742827PINAM46L, G48AS, I54V, V82AL24I, L33F, N83DL10I, I13V, M36L, N37Q, R41RK, K43I, K55R, Q61QE, L63P, A71I, I72IT, L89I, I93LB