Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	B
Gene	PR
Mutation	N83D
Rx	>= 1 PI
IncludeMixtures	No

References	11
Patients	48
Isolates	57

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Rousseau (2000)	MNR10	MNR4415	AJ405955	SQV, IDV, NFV, RTV, Unknown	>142	M46I, I84V, L90M	N83D	L10I, E35D, M36I, N37D, R41K, R57K, I62V, L63P, I64V, A71V, I93L	B
Gonzales (2001)	CA1624	CA4605	AY030712	IDV, SQV, RTV	136	I54IV	L24I, L33F, F53L, G73CS, N83D	I15V, E34Q, M36L, N37S, L38W, R57K, D60DE, I62V, L63P, A71V	B
	CA1886	CA5087	AY030777	SQV, NFV	139	D30N	N83D	I13V, E35D, M36I, N37T, L63P	B
	CA4140	CA9987	AY031119	IDV, NFV	124	V32I, M46I, L90LM	L33F, K43T, N83D	L10N, I13V, M36L, N37S, P39Q, R41K, K55R, I62V, L63P, I64V	B
	CA5239	CA12913	AY031796	IDV, NFV	186	L90M	N83D	W6WL, L19I, E35G, M36I, N37E, D60E, I62V, L63P, I64V, I93L	B
Romano (2002)	MZ-pt19	pt19-t0	AF493354	SQV, NFV, IDV, RTV		M46I, I84V, L90M	L10F, L33I, G73S, N83D	A22V, E35G, M36I, R41K, I62V, L63P, A71V, I72L, I85V	B
Shafer (2003)	A384_0901	0901b	EF548333	NFV	15	I54V, I84V, L90M	N83D	L10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V	B
		0901c	EF548334	NFV	16	I54V, I84V, L90M	N83D	L10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V	B
		0901d		NFV, RTV, APV	160	I54L, I84V, L90M	L33F, N83D	L10I, K20R, E35N, M36L, N37D, I62V, L63P, A71V, L89I	B
Wu (2003)	CA1624	CA17101	AF544506	IDV, SQV, RTV, NFV, APV	209	I54IL, I84IV	L24I, L33F, F53L, G73C, N83D	I15V, A22AV, E34Q, M36L, L38W, P39S, R57K, D60E, I62V, L63P, A71V	B
	CA6800	CA21370	AF544598	SQV, RTV, APV, IDV, LPV	221	M46L, I84V	L33F, N83D	T4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89I	B
	CA9428	CA23148	AF544617	RTV, NFV, LPV	199	I54V, V82A	L24I, L33F, K43T, F53L, N83D	L10I, I13V, K20R, M36I, D60E, I62V, L63P, I64V	B
Gomez-Carrillo (2004)	99376	99376	AY365598	PI	NA	V32I, I54V, L90M	L33F, N83D	L10I, I13V, K14R, M36V, N37S, R41K, L63Q, I64V, A71V	B
	104668	104668	AY365710	PI	NA	I54V, V82S	L33F, F53FL, N83D	L10I, I13V, K14R, M36L, N37D, I62V, L63P, I64V, T74AS	B
Rhee (2005)	CA1624	CA11023	AY796811	IDV, SQV, RTV	157	I54V	L24I, L33F, F53L, G73C, N83D	I15V, E34Q, M36L, N37NS, L38W, P39PS, R57K, D60E, I62V, L63P, A71V	B
	CA6800	CA21302	AY797446	SQV, RTV, APV, IDV, LPV	217	M46L, I84V	L33F, N83D	T4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89I	B
	CA7108	CA41294	AY797531	IDV, NFV, Unknown, LPV	>207	M46I, I84V, L90M	L10F, G73T, N83D	K20R, E34Q, M36I, R41K, I62V, L63P, I64V, I93L	B
	CA7982	CA20462	AY797623	IDV, SQV, RTV, APV	195	I54L, I84V, L90M	L10F, L33LF, N83D	R8Q, T12S, K20R, E34K, E35D, M36I, R41K, I62V, L63P, A71V	B
Baxter (2006)	12-2299	2299-30818	DQ876048	PI	NA	V32I, M46I, L90M	L10F, V11I, L33F, G73S, N83D	T12S, I13V, L19I, E34V, M36L, N37ND, I62V, L63P, A71V	B
	12-1678	1678-30331	DQ876270	PI	NA	M46I, I54V, I84V, L90M	L33F, Q58E, N83D	L10I, I13V, M36L, I62V, L63P, I64V, L89M	B
	12-2091	2091-30711	DQ876411	PI	NA	M46L, I54A, V82A	L24I, L33F, K43T, N83D	L10I, I13V, K20KR, M36L, N37D, Q61QHKN, I62V, L63Q, I64V, I72IV, T74AS	B
	12-1081	1081-30417	DQ876421	PI	NA	M46I, I84V	N83D	L10I, I13V, G16A, K20R, A22V, E35D, M36I, I62V, L63P, A71T	B
	12-1285	1285-30311	DQ876614	PI	NA	M46I, I54L, L76V, I84V, L90M	N83D	L10I, K20R, E34Q, M36D_*, R41K, D60E, I62V, L63P, A71V, I93L	B
	12-2384	2384-30815	DQ876642	PI	NA	M46I, I84V	L10F, N83D, N88D	I13V, G16A, A22V, E34Q, N37ND, R57K, L63P, A71V, T91A	B
	12-2136	2136-30821	DQ876744	PI	NA	M46L, I54V, I84V, L90M	L10F, L33F, N83D	K20R, E35D, M36L, R41K, K45V, K55Q, I62V, L63P, I64V	B
	12-1502	1502-30604	DQ876900	PI	NA	M46L, I54A, V82A	L24I, L33F, K43T, N83D	L10I, I13V, K20KR, M36L, N37D, Q61QHKN, I62V, L63Q, I64V, I72IV, T74AS	B
	12-1181	1181-30507	DQ876950	PI	NA	I54V, V82A	L24I, L33F, F53L, N83D	L10I, I13V, K14R, E35D, M36L, R41K, K55KR, I62IV, L63P, A71V	B
	12-1193	1193-30305	DQ876960	PI	NA	I54A, V82A	L33F, I47IK, N83D	L10I, I13V, K20R, M36L, R41N, K45I, D60E, I62V, L63P, I64V	B
	12-3148	3148-30506	DQ877158	PI	NA	V32I, M46I, I54V, V82A	L33I, F53L, N83D	L10I, I13V, K14M, K20R, M36I, N37D, L63P, I64V, A71V, T91S	B
	12-3060	3060-30415	DQ877165	PI	NA	M46I, I84V, L90M	L10F, L33F, N83D, N88D	T4S, I13V, G16A, L19I, L24L*, E35N, M36I, P39S, I62V, L63P, A71V, I72V	B
	48-1259	1259-31208	DQ877787	PI, RTV, TPV	>25	I54V, I84V, L90M	N83D	L10I, E34Q, M36L, N37D, L38W, R57K, I62V, L63P, A71V, I93L	B
		1259-40720	DQ877786	PI, RTV, TPV	>57	I54V, I84V, L90M	N83D	L10I, T31TA, E34Q, M36L, N37D, L38W, R57K, I62V, L63P, A71V, I93L	B
	48-1433	1433-30220	DQ877823	PI	NA	M46I, I54V, I84V, L90M	Q58E, N83D	L10I, T12N, I13A, K14KI, L19M, K20R, A22V, M36I, R41RK, K55R, R57K, I62V, L63P, I64V, I66V, H69R, T74S, Q92K, I93L, C95F	B
	48-3127	3127-30401	DQ878035	PI	NA	M46L, G48GA, I54V, V82A, L90M	L33F, K43T, N83D	T4TS, L10I, T12P, L19EV, K20R, M36L, N37D, K55KR, R57K, I62V, L63P, A71V, T91TS, Q92K	B
	48-3209	3209-30519	DQ878119	PI	NA	I54V, V82A	L24I, L33F, K43T, F53L, N83D	L10I, L19I, K20R, E35D, M36L, N37D, R41K, R57K, I62V, L63P, A71V	B
	48-4046	4046-30408	DQ878278	PI	NA	M46I, I54V, I84V	L10F, L33F, K43T, N83D	T4A, T12P, I13V, K14R, A22V, E34R, M36A, P39Q, D60E, I62V, L63P, H69Y, A71V, T91AS, Q92K, I93L	B
		4046-40304	DQ878279	PI, RTV, TPV	>47	M46I, I54V, I84V	L33F, K43T, N83D	T4A, T12P, I13V, K14R, A22V, E34R, M36A, P39Q, D60E, I62V, L63P, H69Y, A71V, T91AS, Q92K, I93L	B
	48-4058	4058-30311	DQ878290	PI	NA	M46I, I54V, I84V	L24I, Q58E, N83D	L10I, I13IV, K20R, A22V, E35D, M36I, N37Q, I62V, L63P, I64V, A71V, I72V, T91S, I93L	B
	48-4108	4108-30304	DQ878338	PI	NA	V32I, M46I, I47V, I54M, L90M	L33F, F53L, N83D	L10I, T12P, I15IV, E34Q, R41K, I62V, L63P, C67W, A71I, I72V, G73D, V77I, V82I, Q92K, I93L	B
	48-4140	4140-30424	DQ878372	PI	NA	M46I, I54V, I84V, L90M	L10FI, L33LI, N83D, L89V	V11VL, I13V, K20R, A22V, E34A, E35D, M36I, N37D, I62V, L63P, A71I, I72L, T91TCS, Q92K, I93L	B
	48-4201	4201-30724	DQ878433	PI	NA	M46I, I54V, V82A, I84V, L90M	N83D	L10I, T12P, K14R, K20R, E34R, M36I, N37S, R41K, I62V, L63P, H69HY, A71AT, I72EV, I93L	B
	48-5011	5011-31014	DQ878546	PI, RTV, TPV	>22	M46I, I54V, I84V	V11I, L24I, N83D	I13V, K20R, A22V, E35D, M36I, K55R, R57K, Q61E, I62V, L63P, A71T, I72V, T91TCS	B
		5011-40722	DQ878545	PI, RTV, TPV	>63	M46I, I47V, I54V, I84V	V11I, N83D	L10I, I13V, K20R, A22V, L24M, E35D, M36I, K55KR, R57K, Q61E, I62V, L63P, A71T, I72V, T91S	B
	48-6166	6166-30729	DQ878742	PI	NA	I54V, I84V, L90M	V11VI, L33I, G73GS, N83D, L89V	L10I, I13V, L19LV, K20R, A22V, E35D, M36I, N37E, I62IV, L63P, A71AITV, Q92QK	B
	48-6329	6329-30924	DQ878862	PI	NA	I54IL, I84V	L33I, N83D	L10IV, T12IV, I13AV, A22V, E35D, M36I, Q61HN, I62V, L63Q, I64V, A71AT, I72IT, T74S, V75VI, T91TS	B
	48-6344	6344-30918	DQ878867	PI	NA	M46I, I47IV, I54IL, L76LV, I84V, L90M	L10FI, L33I, N83D, L89V	I13V, Q18H, A22V, E35N, M36I, N37D, R41RK, K55KR, I62V, L63P, A71V	B
	48-9071	9071-30901	DQ877285	PI	NA	M46I, I47V, I54V, V82A, L90M	L33F, F53L, Q58E, N83D	L10V, G16A, K20R, E35D, M36I, N37D, R57K, D60E, Q61N, L63P, L89I	B
	48-9184	9184-30901	DQ877532	PI	NA	M46L, I54V, V82A, L90M	L33F, K43T, F53L, N83D	L10I, I13V, K20R, M36L, N37T, K55KR, R57RK, D60DE, I62V, L63P, I64V, L89LM	B
	48-9088	9088-30827	DQ877659	PI	NA	G48V, I54V, V82A	L33F, K43KT, F53L, N83D	L10I, I13V, L19I, K20R, E35D, M36I, N37C, R57K, I62V, L63Q, I64V, C67Y, I72V, V75I, T91TA	B
De Meyer (2009)	DRV01	DRV01-48w		PI, DRV, RTV	>48	V32I, M46I, I47V, I54M, I84V	L10F, V11I, L24I, L33F, Q58E, N83D	I13V, G16E, M36I, L63P, I64V	B
	DRV02	DRV02BL		PI	NA	V32I, M46I, I84V, L90M	L33F, N83D	L10I, I13V, M36L, I62V, I64V	B
		DRV02-48w		PI, DRV, RTV	>48	V32I, M46I, L76V, I84V, L90M	L33F, N83D	L10I, I13V, M36L, I62V, I64V	B
Dau (2010)	08383A	08383A	GU581908	PI	NA	M46I, I54V, I84V	L24I, N83D, L89V	L10I, I13V, K14KN, L19Q, A22V, M36L, N37D, D60E, I62V, L63P, A71V, I72T, T91TS, Q92K	B
	10604A	10604A	GU582013	PI	NA	V32I, M46I, I84V	L33F, F53L, N83D	L10V, I13V, E34EQ, E35D, M36L, N37D, L63LP, I64V, A71AV, G73GV, T74S	B
Jones (2012)	156312	156312	JN669860	PI	NA	M46MI, I47V, G48A, I54V, V82A	L24I, L33F, K43T, N83D	L10I, K20R, M36L, N37S, R41K, D60E, I62V, L63P, I64V, A71T, T91S	B
	175671	175671	JN670367	PI	NA	G48M, I84V	N83D	I13V, E35D, M36I, R57K, I62V, I64V, T74S	B
	207115	207115	JN671422	PI	NA	V32I, L90M	L33F, M46MV, F53L, N83D, L89V	L10I, I13V, M36V, N37S, R41K, I62IV, L63Q, A71V	B

Protease Inhibitors

Database

Resources

Team