<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation V82C
Rx >= 1 PI
IncludeMixtures No
References 14
Patients 110
Isolates 117
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Sevin (2000)SA-231025cSA-231025cAF226129SQV121G48V, I54V, V82C, L90M L10I, L19IM, N37S, L63P, H69Q, A71V, I72IT, I93MB
Margot (2002)MM-2087365092087365091 PINAG48V, V82C, L90M I15V, E35D, L63P, A71V, I93LB
Romano (2002)MZ-pt31pt31-t0AF493366IDV, SQV, RTV G48V, I54V, V82C, I84VQ58EL10I, E35D, M36I, D60E, I62V, L63P, H69N, A71V, V77I, I93MB
  pt31-t1AF493405IDV, SQV, RTV, LPV G48V, I54V, V82C, I84VQ58EL10I, E35D, D60E, I62V, L63P, H69N, A71V, V77I, I93MB
 MZ-pt32pt32-t0AF493367SQV, IDV, NFV, RTV M46L, G48V, V82C, L90MQ58EL10I, I62V, L63P, I64L, A71T, V77I, I93LB
  pt32-t1AF493406SQV, IDV, NFV, RTV, LPV M46L, G48V, I54V, V82C, L90MQ58EL10I, I62V, L63P, I64L, A71T, V77I, I93LB
Tural (2002)288789288789 SQV, RTV118I54V, V82C, L90M I15V, L63P, A71VB
Wu (2003)CA4514CA20511AF544565IDV, RTV, NFV233I54V, V82C, L90MN88DL10I, E34Q, R41K, Q61N, L63P, V77I, I93LB
Baxter (2006)12-14951495-30527DQ876046PINAM46L, I54V, V82C, I84VL24I, V32V_F, T74PL10I, I13V, K14KR, L19LI, M36L, R41K, K55R, I62V, L63P, L89MB
 12-12611261-30320DQ876085PINAM46L, I54V, V82C, I84V, L90ML10F, L33F, F53L, T74PI13V, K55R, D60E, I62V, L63P, I66F, A71V, I72V, T91TSB
  1261-30417DQ877129PI, RTV, TPV>4M46L, I54V, V82C, I84V, L90ML10F, L33F, F53L, T74PI13V, K55R, D60E, I62V, L63P, I66F, A71V, I72V, T91SB
 12-10131013-30228DQ876230PINAM46L, I54V, V82C, I84VL10F, L24I, L33F, K43TI13V, G16A, Y59YF, Q61R, L63P, I64V, K70KR, A71V, I72E, T74S, V77I, P79Q, T91S, I93LB
 12-13221322-30423DQ876328PINAM46I, I54V, V82C, I84V, L90ML33F, G73S, L89VL10I, V11L, G16A, E34Q, K55R, R57K, L63P, H69Q, K70E, A71V, I72L, T91S, I93LB
 12-10631063-30425DQ876378PINAM46L, I54V, V82C, I84V, L90ML10FR41K, D60E, L63P, A71V, P79N, I93LB
 12-16601660-30528DQ876386PINAM46I, I47V, I54V, V82C, I84V, L90ML10F, V11I, F53L, G73A, L89VI13V, I15V, G16A, K20I, K55R, R57K, L63P, T74S, P79AB
 12-20922092-30724DQ876412PINAD30N, I54V, V82C, I84V, L90ML10F, L33F, N88DT12S, I13V, K45R, Q61QH, I62V, L63P, I66V, A71T, I72T, P79X, Q92R, I93L, C95FB
 12-16931693-30423DQ876525PINAI54M, V82C, I84VL24I, L33F, K43TL10I, I13V, K20KR, E35D, M36I, L63P, K70KE, A71VB
 12-17621762-30417DQ876621PINAM46L, I54V, V82C, I84V, L90MV11VI, L33F, T74PL10I, I13V, R41K, I62V, L63P, A71T, L89R, I93LB
 12-24272427-30820DQ876660PINAM46LV, I54V, L76V, V82CL10FI15V, N37D, I62V, L63P, I93LB
 12-12621262-30324DQ876710PINAV32I, M46I, I47V, I54L, V82C, L90MK43T, L89VL10I, V11L, I15V, L19LQ, K20I, E35D, M36I, N37ND, R41K, L63P, A71V, I85V, Q92KB
 12-13981398-30623DQ876766PINAM46I, I47V, I54V, V82C, L90ML33F, F53L, Q58E, G73AL10I, L19I, E34T, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93LB
  1398-31001DQ879106PI, RTV, TPV>14M46I, I47V, I54V, V82C, L90ML33F, F53L, Q58E, G73AL10IV, L19I, E34T, K55KR, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93LB
  1398-40712DQ879105PI, RTV, TPV>55M46I, I47V, I54V, V82C, L90ML33F, Q58E, G73AL10V, I13V, I15V, L19I, E34T, L38LW, R41RK, K55R, Q61H, I62V, L63P, C67CW, A71T, I72E, V77I, I93LB
 12-11471147-30325DQ876850PINAM46I, I54V, V82C, L90ML10F, G73ST12A, I13V, I15V, L19P, K20I, E35DN, M36I, N37E, R41K, K55R, L63P, A71V, I72R, I93LB
 12-17581758-30710DQ876871PINAM46MI, I54V, L76V, V82C, I84IV L10IV, I15IV, L19I, K20R, E35D, M36I, N37D, D60E, Q61EK, I62IV, L63P, A71V, I93LB
 12-16331633-30313DQ876967PINAM46I, G48V, I54S, V82C, L90ML33LFL10I, R41K, L63GS, A71V, V77I, I93LB
 12-17681768-30522DQ877075PINAD30N, I54L, V82C, L90ML10F, L33F, K43T, N88DI13V, I15V, K20T, E35D, M36I, N37D, R41RK, R57K, I62V, L63P, K70KN, A71V, I85IV, L89LM, Q92QK, T96SB
 12-30013001-30219DQ877178PINAV32I, M46I, I47V, I54L, V82C, L90ML10F, L33F, G73CT12E, G16A, L19I, N37T, R41RK, L63P, I64V, I72L, I93LB
 12-30963096-30513DQ877196PINAI54V, V82C, L90ML10F, G73SI13M, I15V, G17E, K20V, L24F, M36I, N37D, K43KR, R57K, D60E, I62V, L63P, A71V, I72RB
 12-30713071-40708DQ879129PI, RTV, TPV>60M46L, I54V, V82C, I84V, L90ML33F, Q58E, T74PI13V, L19I, K45R, L63P, A71V, V77I, I93LB
 48-11111111-30630DQ877377PINAM46I, I54V, V82C, I84V, L90ML10F, L33F, G73CN37S, R41K, K55R, R57K, I62V, L63P, I64V, I66FL, C67Y, A71T, I72T, I93LB
 48-10261026-30623DQ877404PINAM46I, V82C, I84VL24I, Q58E, T74PL10I, I15V, L19T, K55R, L63P, A71AV, I72IR, V77IB
 48-12591259-30616DQ877785PINAI54V, L76V, V82C, L90ML10F, Q58QEI13V, L19LI, E34Q, M36L, N37D, L38W, R57K, Q61E, I62V, L63P, A71IV, I72IATV, I93LB
 48-22402240-30722DQ877879PINAM46I, I54L, L76V, V82C, I84IV, L90MV11I, Q58QE, G73AT, L89LVL10V, I13V, I15V, Q18H, K20I, M36I, N37D, D60E, I62V, L63P, A71V, I72L, T80TASB
 48-30233023-30303DQ877933PINAM46I, V82C, I84V, L90MF53L, T74PL10I, R41K, I62V, L63P, I64V, A71V, V77I, I93LB
 48-31063106-30425DQ878012PINAM46L, I54V, V82C, L90ML10F, L33I, Q58EK20R, L24F, E35D, M36I, N37DE, K55R, R57K, I62IV, L63P, A71V, I93LB
 48-31433143-30430DQ878054PINAM46I, G48V, I54S, V82C, L90M T4TS, L10V, R41K, I62V, L63A, I64V, A71V, I72V, V77I, I93LB
 48-31763176-30425DQ878085PINAI47V, G48V, I54M, L76V, V82C, L90MF53L, G73A, L89VL10I, V11L, I13V, G16A, K20V, E34Q, N37D, L63P, H69Y, A71V, V77I, I93LB
 48-31953195-30512DQ878105PINAM46L, I54V, V82C, L90MG73C, L89VI13V, K20I, E35D, M36I, N37D, I62V, L63P, I64V, H69R, T74SB
 48-31973197-30507DQ878107PINAM46I, I54V, V82C, I84V, L90ML10F, L33F, G73TL19I, E34Q, R41K, L63P, A71V, I93LB
 48-32123212-30731DQ878122PINAM46L, I54V, V82C, L90MV11I, G73C, L89VI13V, K20I, E35DN, M36I, N37D, I62V, L63P, I64V, H69R, T74SB
 48-33093309-30902DQ878213PINAI47V, G48MV, I54V, V82C, L90ML33F, K43T, G73AT, L89VL10IV, E35D, M36I, Q61QE, I62V, L63P, A71T, I72IT, I93LB
 48-40714071-30218DQ878300PINAV32I, M46I, I47V, I54V, V82C, L90ML10F, V11VI, F53LK14R, I15V, I62V, L63P, A71V, I72L, I85VB
 48-40964096-30422DQ878326PINAM46L, I54V, V82C, I84V, L90ML10F, V11VI, L33F, G73ST4TA, L19LI, E34Q, Q61H, I62V, L63P, A71V, V77VI, P79DB
 48-42454245-30513DQ878476PINAM46I, I54V, V82C, I84V, L90MG73SL10I, N37D, K55R, R57RK, L63P, I66IV, A71VB
 48-42794279-30919DQ878503PINAI54V, V82C, I84V, L90ML10F, L33F, F53L, T74PK14R, E34Q, N37D, R41K, K55R, Q61E, I62V, L63P, A71V, V77I, P79D, I93LB
 48-60146014-30313DQ878611PINAM46L, I54V, V82C, I84VL24I, L33F, K43T, T74PL10I, I13V, I15IV, K20R, E35D, M36I, N37D, L63P, I72V, T91TSB
 48-60176017-30320DQ878616PINAM46I, I54V, L76V, V82C, L90ML10FT12S, I13M, I15V, L19Q, K20I, M36I, N37D, K55R, I62IV, L63P, H69K, A71V, I93LB
 48-60456045-30515DQ878644PINAV32I, M46I, I47V, V82C, L90MG73SI15V, K20T, E35D, N37T, I62V, L63P, A71V, V77I, C95LB
 48-60836083-30521DQ878678PINAM46I, I54V, V82C, I84V, L90ML10F, V11I, K43T, G73TI13V, I15V, K20I, L24M, M36I, L63P, C67Y, H69R, A71VB
 48-60856085-30526DQ878680PINAG48M, I54V, V82C, L90MF53L, G73SL10I, I13V, I15V, K20T, E34EQ, M36I, N37ND, Q61QE, I62V, L63P, A71V, C95LB
 48-61986198-30728DQ878770PINAG48V, I54V, V82C, L90ML33F, G73SL10I, T12V, G16A, R57K, I62V, L63P, A71V, I72L, V77VI, I93LB
 48-62026202-30729DQ878774PINAM46I, I54V, V82C, L90MG73SL10V, I13V, I15V, L19I, K20T, I62V, L63P, A71TB
  6202-40421DQ878775PI, RTV, TPV>38M46I, I54V, V82C, I84VG73SL10V, I13V, I15V, L19I, K20T, M36I, I62V, L63P, A71TB
 48-62586258-30902DQ878815PINAM46I, I50IV, I54V, V82C, L90ML10F, G73AI13IV, Q18QH, L19LP, K20I, M36MI, N37D, L63P, I66IF, C67FY, H69K, A71T, I72R, I93LB
 48-63776377-30930DQ878887PINAM46L, I54V, L76V, V82C, L90MF53LL10V, I15V, G16A, R41N, L63P, H69K, A71VB
 48-70817081-30910DQ878936PINAI54V, V82C, I84V, L90ML10F, Q58E, G73TI62IV, L63P, A71V, I93LB
 48-71057105-30910DQ878959PINAM46I, I50V, I54V, V82CV11VI, L33F, Q58EL10I, K20R, E35D, M36I, K55R, D60E, I62V, L63P, I64L, A71V, I85V, L89MB
 48-71427142-30731DQ878980PINAM46L, G48V, I54V, V82C, I84V, L90ML33F, Q58EL10I, G16GAE, N37C, I62V, L63PS, A71V, I72IK, I93LB
 48-90619061-30820DQ877475PINAM46I, I54V, V82C, I84VL10F, L24I, L33FL63P, A71I, I72T, P79N, T91S, I93LB
 48-93549354-30924DQ877527PINAM46I, I54V, V82C, I84V, L90ML10F, L33F, G73TI13V, L63P, K70T, A71V, P79A, I93LB
 48-93099309-30918DQ877568PINAM46MI, I54AS, V82CL24I, L33F, K43TL10I, I13V, I15V, K20R, E35D, M36I, N37D, R41K, I62V, L63P, I64V, A71V, T74S, I85V, I93LB
 48-93749374-30929DQ877682PINAM46L, I54ST, V82C, L90ML10F, L33F, K43T, T74PI13V, L19T, I62V, L63P, A71T, V77I, L89R, I93LB
 48-91139113-30918DQ877699PINAV32I, M46I, I47V, V82C, L90ML10F, F53FL, G73TI62V, L63P, V77I, I93LB
 48-91259125-30918DQ877730PINAM46L, I54A, V82C, I84VL24I, L33F, K43TL10I, L19I, K20R, E34EQ, E35D, M36I, N37S, I62V, L63P, I64V, A71V, Q92KB
Rhee (2009)CA37887CA84415FJ983564SQV, RTV445I54V, V82C, L90MF53LL10LV, K20R, E35D, M36I, R41K, D60E, I62V, L63P, I64L, A71VB
Dau (2010)06682A06682AGU581765PINAM46L, I54V, V82C, I84V, L90ML33FL10I, L63P, A71V, V77I, I93LB
 06928A06928AGU581800PINAI54V, V82C, I84V, L90MV11VI, L33F, K43T, G73T, L89VL10I, I13V, K20R, E35D, M36I, N37D, I62V, L63P, A71T, P79SB
 07783A07783AGU581869PINAM46I, I54V, V82C, L90MG73SL10I, K20I, M36I, I62IV, L63P, I66F, C67CY, A71V, I93LB
 10498A10498AGU582003PINAI54V, V82C, I84VK43KTL10I, I13V, L19I, K20R, E35D, M36I, N37D, R41RK, D60E, Q61E, L63P, A71AV, L89LM, I93LB
 11917A11917AGU582055PINAI54V, V82C L10I, N37NSTY, I62V, L63HP, A71AV, I93LB
Rhee (2010)CA25655CA84315GQ213176PI, Unknown, RTV, APV>74M46ML, I54V, V82C, L90ML10F, L33F, G73S, L89VI13IV, N37S, R41K, K43R, K55R, R57K, I62V, L63P, I64IM, A71V, I93LB
Barber (2012)5606956069JQ361666LPV M46I, I54V, L76V, V82C L10V, I13V, K14R, L63P, I64VB
Jones (2012)135338135338JN669541PINAM46I, I54V, L76V, V82C, L90ML10FI, Q58E, G73AI13V, Q18H, K20I, M36MI, K55R, I62V, L63P, I64V, C67CF, K70R, A71V, I72LB
 142746142746JN669624PINAM46I, I54V, L76V, V82C, L90ML10F, Q58E, G73AI13V, Q18H, K20I, M36I, K55R, I62V, L63P, I64V, K70R, A71V, I72LB
 149974149974JN669742PINAM46I, I54V, V82C, L90ML10F, K43KT, N88DK14GR, I15V, K20I, R41K, I62V, L63P, A71V, I72L, V77I, I85VB
 185252185252JN670699PINAI54V, V82CL33FT12K, I13V, K14N, G16A, Q18H, L19I, K20KR, M36I, I62IV, L63C, I72IV, T74A, L89MB
 194881194881JN670954PINAM46I, I54V, V82C, L90MK43TI15V, K20IV, N37NS, R41RK, I62V, L63P, C67F, A71V, I72R, V77I, I85V, N88EB
Kouri (2012)CU1383-10CU1383-10JQ585426PINAG48V, I54V, V82C, L90M L10I, E34K, R41K, I62V, L63H, H69Y, A71V, I72V, V77I, I93LB
 CU1916-10CU1916-10JQ585443PINAG48V, V82C, L90ML33LF, G73SL10I, I62V, L63PS, A71V, I72IV, V77IB
Grossman (2014)2121KF135026SQV, RTV, LPV52I47IV, G48V, I54A, V82C, L90ML33F, G73GSL10I, I62V, L63P, A71I, I72R, V77I, I93LB
  21KF135027SQV, RTV, LPV102I47V, G48V, I54A, V82C, L90ML33F, G73SL10I, E34Q, N37D, I62V, L63P, A71I, I72R, V77I, I93LB
Diaz (2015)RenG16511RenG16511KT747539PINAM46I, I54V, V82C, L90MV11VI, L33F, G73TT4TS, L10V, T12K, I15V, L19LM, K20T, E35N, M36I, N37E, R41K, K43R, R57K, Q61H, I62V, L63P, A71T, I72L, I85VB
 RenG15934RenG15934KT746962PINAM46I, V82C, I84V, L90ML33F, Q58E, G73ATL10I, T12E, G16A, N37D, K55R, I62V, L63P, I72M, I93LB
 RenG15585RenG15585KT746613PINAV32I, I54V, V82C, I84V, L90ML10F, V11I, L33F, F53L, G73AITV, T74AP, L89VI13V, L19V, K20M, M36I, K55R, I62V, C67F, H69HY, K70E, A71V, I72T, T91SB
 RenG16625RenG16625KT747653PINAM46I, I54L, L76V, V82CL10F, L24IT12D, I13M, L19I, K20I, M36I, N37ND, L63P, I64V, H69K, I72VB
 RenG16799RenG16799KT747827PINAM46I, I54A, V82C, I84V, L90ML10F, Q58E, G73A, L89VV11L, I13V, I15V, G16A, L19T, K20I, M36I, L63P, A71I, I72E, I93LB
 RenG16334RenG16334KT747362PINAM46I, I54V, L76V, V82CL24IL10I, T12EK, I13V, I15V, K20I, E35DN, M36I, N37E, R41RK, K55R, R57K, I62V, L63P, I64V, T74SB
 RenG15665RenG15665KT746693PINAV32I, M46I, I47A, V82CQ58EK55R, L63PB
 RenG16684RenG16684KT747712PINAM46I, I50L, V82C, N88SQ58EL10I, N37S, I62V, L63P, H69Q, A71IV, V77I, I93LB
 RenG15903RenG15903KT746931PINAM46I, I54V, V82C, L90ML10F, G73TT12N, L19LIM, K20I, M36MI, R41K, I62V, L63P, I66F, C67CY, A71T, I72T, V77VI, I93L, C95VB
 RenG16722RenG16722KT747750PINAV32I, I47A, V82C L10V, T12K, L19I, E34Q, M36MI, K55N, L63P, K70TB
 RenG16094RenG16094KT747122PINAM46L, I54IV, V82C, L90ML33I, G73GSL10LR, I13V, Q18H, K20T, E35D, M36I, N37ND, R41RK, I62IV, L63P, A71IV, I93LB
 RenG17406RenG17406KT748434PINAM46I, I54V, V82CL10F, F53FL, L89VI13V, K20M, E35ED, M36V, N37E, K55KR, R57RK, D60E, L63P, A71T, Q92RB
 RenG16623RenG16623KT747651PINAM46I, I54V, V82C, I84V, L90ML10F, Q58E, G73T, T74TPI13M, I15V, G16A, K20I, M36I, R41K, L63P, I64V, I66V, P79PS, I93LB
 RenG14699RenG14699KT745727PINAV32I, M46L, I54L, L76V, V82C, I84VV11I, L33F, K43TL10I, I13V, K14R, G16E, K55KR, L63R, A71V, I72V, P79PS, L89MB
 RenG14664RenG14664KT745692PINAV32I, M46I, I47V, I54AV, V82C, L90ML10F, F53FL, L89VI15V, K20IT, E35D, N37H, R41K, I62IV, L63P, A71IV, G73E, I85VB
 RenG15407RenG15407KT746435PINAM46I, I54V, V82C, I84V, L90ML10F, V11I, L33F, G73SK20R, E34Q, E35D, M36V, N37D, L38I, R41K, K55N, I62V, L63P, A71V, I72IT, V77I, I93LB
 RenG13888RenG13888KT744916PINAM46I, I54V, L76V, V82C, L90MQ58EL10V, I13V, I15V, G16A, K20MT, M36MI, R41K, K55R, L63P, A71V, I93LB
 RenG15207RenG15207KT746235PINAM46I, I54V, V82C, L90ML10F, G73SI13V, I15V, K20I, E35D, M36I, N37E, Q61H, L63P, H69K, A71T, I72TB
 RenG14585RenG14585KT745613PINAM46I, I47V, I54V, V82CL10F, N88D, L89VT4S, T12K, I13V, K20T, N37D, L63P, A71V, I72M, V77IB
 RenG15204RenG15204KT746232PINAM46I, I54V, V82C, L90M L10LI, T12N, I15V, L19P, K20I, E21EQ, M36I, N37E, H69K, A71AT, L89IB
 RenG13780RenG13780KT744808PINAM46I, I54V, V82C, I84V, L90ML10F, Q58E, G73STL19LI, K20R, M36I, F53FY, L63P, I66V, H69K, A71V, I72ITB
 RenG12594RenG12594KT743622PINAM46I, I54V, V82CL24I, L33LF, Q58E, G73SQ7E, L10I, E35D, M36MIV, N37S, K55KR, R57RK, I62V, L63P, A71V, I72T, V77I, I93LB
 RenG12094RenG12094KT743122PINAV32VI, M46I, I47IV, I50IV, I54IM, V82CL10F, Q58EK14R, Q61H, L63AP, L89M, I93LB
 RenG12060RenG12060KT743088PINAM46I, I54V, L76V, V82C, L90M L10V, K20R, E35D, M36I, N37D, R41K, K55KR, R57K, I62V, L63P, A71V, I72IV, I93LB
 RenG13430RenG13430KT744458PINAM46I, I54V, V82C, I84V, L90ML33F, K43T, G73SL10IV, V11L, I13V, G16A, N37S, D60E, Q61E, I62V, L63P, A71V, I72T, I93LB
 RenG12646RenG12646KT743674PINAM46I, I54IV, V82C, N88S, L90M L10I, K55KR, L63P, H69Q, A71IV, T74S, V77I, I93LB
 RenG13307RenG13307KT744335PINAV82C, L90M N37S, I62M, L63P, A71V, V77IB
 RenG10560RenG10560KT741588PINAM46I, I50V, I54V, V82C, L90ML10F, L23I, L33I, K43T, N88D, L89VI13V, K14R, E35D, M36I, I62V, L63P, A71IB
 RenG11049RenG11049KT742077PINAV32I, M46I, I54M, V82C, I84V, L90MV11I, L23I, L33F, F53L, Q58E, T74P, L89VL10I, T12N, I13V, I15V, K20R, E34Q, E35D, M36L, R41K, D60E, I62V, L63P, I64V, G73V, V77IB
 RenG11684RenG11684KT742712PINAM46I, I54V, V82C, I84V, L90M L10I, T12P, P39Q, R41K, D60E, I62V, L63P, A71T, I72K, I93L, C95FB
 RenG10855RenG10855KT741883PINAV32I, M46I, I47A, V82C E21K, L63P, V77IB
 RenG10511RenG10511KT741539PINAM46I, I54V, V82C, L90M L10I, I13M, I15V, L19V, K20L, M36I, N37D, L63P, K70R, A71T, I72L, I85V, Q92R, I93L, C95FB
 RenG11392RenG11392KT742420PINAG48M, I50V, V82C, L90ML33F, G73AL10I, I13V, G16A, L19V, F53I, Q61QH, L63P, H69HY, K70KE, A71T, I72E, I93LB
 RenG10214RenG10214KT741242PINAM46I, I54V, V82C, I84V, L90MV11I, G73GSL10I, T12S, I13V, I15V, L19P, K20L, L33L_L, M36V, P39T, I62V, L63P, H69K, A71V, I72L, P79PAB
 RenG11303RenG11303KT742331PINAM46I, I54V, V82C, N88S, L90M L10V, T12P, K14R, I15V, G16A, K20I, R41K, L63P, A71I, T74S, V77I, I93LB