Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	B
Gene	PR
Mutation	V82C
Rx	>= 1 PI
IncludeMixtures	No

References	11
Patients	72
Isolates	78

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Sevin (2000)	SA-231025c	SA-231025c	AF226129	SQV	121	G48V, I54V, V82C, L90M		L10I, L19IM, N37S, L63P, H69Q, A71V, I72IT, I93M	B
Margot (2002)	MM-208736509	2087365091		PI	NA	G48V, V82C, L90M		I15V, E35D, L63P, A71V, I93L	B
Romano (2002)	MZ-pt31	pt31-t0	AF493366	IDV, SQV, RTV		G48V, I54V, V82C, I84V	Q58E	L10I, E35D, M36I, D60E, I62V, L63P, H69N, A71V, V77I, I93M	B
		pt31-t1	AF493405	IDV, SQV, RTV, LPV		G48V, I54V, V82C, I84V	Q58E	L10I, E35D, D60E, I62V, L63P, H69N, A71V, V77I, I93M	B
	MZ-pt32	pt32-t0	AF493367	SQV, IDV, NFV, RTV		M46L, G48V, V82C, L90M	Q58E	L10I, I62V, L63P, I64L, A71T, V77I, I93L	B
		pt32-t1	AF493406	SQV, IDV, NFV, RTV, LPV		M46L, G48V, I54V, V82C, L90M	Q58E	L10I, I62V, L63P, I64L, A71T, V77I, I93L	B
Tural (2002)	288789	288789		SQV, RTV	118	I54V, V82C, L90M		I15V, L63P, A71V	B
Wu (2003)	CA4514	CA20511	AF544565	IDV, RTV, NFV	233	I54V, V82C, L90M	N88D	L10I, E34Q, R41K, Q61N, L63P, V77I, I93L	B
Baxter (2006)	12-1495	1495-30527	DQ876046	PI	NA	M46L, I54V, V82C, I84V	L24I, V32V_F, T74P	L10I, I13V, K14KR, L19LI, M36L, R41K, K55R, I62V, L63P, L89M	B
	12-1261	1261-30320	DQ876085	PI	NA	M46L, I54V, V82C, I84V, L90M	L10F, L33F, F53L, T74P	I13V, K55R, D60E, I62V, L63P, I66F, A71V, I72V, T91TS	B
		1261-30417	DQ877129	PI, RTV, TPV	>4	M46L, I54V, V82C, I84V, L90M	L10F, L33F, F53L, T74P	I13V, K55R, D60E, I62V, L63P, I66F, A71V, I72V, T91S	B
	12-1013	1013-30228	DQ876230	PI	NA	M46L, I54V, V82C, I84V	L10F, L24I, L33F, K43T	I13V, G16A, Y59YF, Q61R, L63P, I64V, K70KR, A71V, I72E, T74S, V77I, P79Q, T91S, I93L	B
	12-1322	1322-30423	DQ876328	PI	NA	M46I, I54V, V82C, I84V, L90M	L33F, G73S, L89V	L10I, V11L, G16A, E34Q, K55R, R57K, L63P, H69Q, K70E, A71V, I72L, T91S, I93L	B
	12-1063	1063-30425	DQ876378	PI	NA	M46L, I54V, V82C, I84V, L90M	L10F	R41K, D60E, L63P, A71V, P79N, I93L	B
	12-1660	1660-30528	DQ876386	PI	NA	M46I, I47V, I54V, V82C, I84V, L90M	L10F, V11I, F53L, G73A, L89V	I13V, I15V, G16A, K20I, K55R, R57K, L63P, T74S, P79A	B
	12-2092	2092-30724	DQ876412	PI	NA	D30N, I54V, V82C, I84V, L90M	L10F, L33F, N88D	T12S, I13V, K45R, Q61QH, I62V, L63P, I66V, A71T, I72T, P79X, Q92R, I93L, C95F	B
	12-1693	1693-30423	DQ876525	PI	NA	I54M, V82C, I84V	L24I, L33F, K43T	L10I, I13V, K20KR, E35D, M36I, L63P, K70KE, A71V	B
	12-1762	1762-30417	DQ876621	PI	NA	M46L, I54V, V82C, I84V, L90M	V11VI, L33F, T74P	L10I, I13V, R41K, I62V, L63P, A71T, L89R, I93L	B
	12-2427	2427-30820	DQ876660	PI	NA	M46LV, I54V, L76V, V82C	L10F	I15V, N37D, I62V, L63P, I93L	B
	12-1262	1262-30324	DQ876710	PI	NA	V32I, M46I, I47V, I54L, V82C, L90M	K43T, L89V	L10I, V11L, I15V, L19LQ, K20I, E35D, M36I, N37ND, R41K, L63P, A71V, I85V, Q92K	B
	12-1398	1398-30623	DQ876766	PI	NA	M46I, I47V, I54V, V82C, L90M	L33F, F53L, Q58E, G73A	L10I, L19I, E34T, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93L	B
		1398-31001	DQ879106	PI, RTV, TPV	>14	M46I, I47V, I54V, V82C, L90M	L33F, F53L, Q58E, G73A	L10IV, L19I, E34T, K55KR, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93L	B
		1398-40712	DQ879105	PI, RTV, TPV	>55	M46I, I47V, I54V, V82C, L90M	L33F, Q58E, G73A	L10V, I13V, I15V, L19I, E34T, L38LW, R41RK, K55R, Q61H, I62V, L63P, C67CW, A71T, I72E, V77I, I93L	B
	12-1147	1147-30325	DQ876850	PI	NA	M46I, I54V, V82C, L90M	L10F, G73S	T12A, I13V, I15V, L19P, K20I, E35DN, M36I, N37E, R41K, K55R, L63P, A71V, I72R, I93L	B
	12-1758	1758-30710	DQ876871	PI	NA	M46MI, I54V, L76V, V82C, I84IV		L10IV, I15IV, L19I, K20R, E35D, M36I, N37D, D60E, Q61EK, I62IV, L63P, A71V, I93L	B
	12-1633	1633-30313	DQ876967	PI	NA	M46I, G48V, I54S, V82C, L90M	L33LF	L10I, R41K, L63GS, A71V, V77I, I93L	B
	12-1768	1768-30522	DQ877075	PI	NA	D30N, I54L, V82C, L90M	L10F, L33F, K43T, N88D	I13V, I15V, K20T, E35D, M36I, N37D, R41RK, R57K, I62V, L63P, K70KN, A71V, I85IV, L89LM, Q92QK, T96S	B
	12-3001	3001-30219	DQ877178	PI	NA	V32I, M46I, I47V, I54L, V82C, L90M	L10F, L33F, G73C	T12E, G16A, L19I, N37T, R41RK, L63P, I64V, I72L, I93L	B
	12-3096	3096-30513	DQ877196	PI	NA	I54V, V82C, L90M	L10F, G73S	I13M, I15V, G17E, K20V, L24F, M36I, N37D, K43KR, R57K, D60E, I62V, L63P, A71V, I72R	B
	12-3071	3071-40708	DQ879129	PI, RTV, TPV	>60	M46L, I54V, V82C, I84V, L90M	L33F, Q58E, T74P	I13V, L19I, K45R, L63P, A71V, V77I, I93L	B
	48-1111	1111-30630	DQ877377	PI	NA	M46I, I54V, V82C, I84V, L90M	L10F, L33F, G73C	N37S, R41K, K55R, R57K, I62V, L63P, I64V, I66FL, C67Y, A71T, I72T, I93L	B
	48-1026	1026-30623	DQ877404	PI	NA	M46I, V82C, I84V	L24I, Q58E, T74P	L10I, I15V, L19T, K55R, L63P, A71AV, I72IR, V77I	B
	48-1259	1259-30616	DQ877785	PI	NA	I54V, L76V, V82C, L90M	L10F, Q58QE	I13V, L19LI, E34Q, M36L, N37D, L38W, R57K, Q61E, I62V, L63P, A71IV, I72IATV, I93L	B
	48-2240	2240-30722	DQ877879	PI	NA	M46I, I54L, L76V, V82C, I84IV, L90M	V11I, Q58QE, G73AT, L89LV	L10V, I13V, I15V, Q18H, K20I, M36I, N37D, D60E, I62V, L63P, A71V, I72L, T80TAS	B
	48-3023	3023-30303	DQ877933	PI	NA	M46I, V82C, I84V, L90M	F53L, T74P	L10I, R41K, I62V, L63P, I64V, A71V, V77I, I93L	B
	48-3106	3106-30425	DQ878012	PI	NA	M46L, I54V, V82C, L90M	L10F, L33I, Q58E	K20R, L24F, E35D, M36I, N37DE, K55R, R57K, I62IV, L63P, A71V, I93L	B
	48-3143	3143-30430	DQ878054	PI	NA	M46I, G48V, I54S, V82C, L90M		T4TS, L10V, R41K, I62V, L63A, I64V, A71V, I72V, V77I, I93L	B
	48-3176	3176-30425	DQ878085	PI	NA	I47V, G48V, I54M, L76V, V82C, L90M	F53L, G73A, L89V	L10I, V11L, I13V, G16A, K20V, E34Q, N37D, L63P, H69Y, A71V, V77I, I93L	B
	48-3195	3195-30512	DQ878105	PI	NA	M46L, I54V, V82C, L90M	G73C, L89V	I13V, K20I, E35D, M36I, N37D, I62V, L63P, I64V, H69R, T74S	B
	48-3197	3197-30507	DQ878107	PI	NA	M46I, I54V, V82C, I84V, L90M	L10F, L33F, G73T	L19I, E34Q, R41K, L63P, A71V, I93L	B
	48-3212	3212-30731	DQ878122	PI	NA	M46L, I54V, V82C, L90M	V11I, G73C, L89V	I13V, K20I, E35DN, M36I, N37D, I62V, L63P, I64V, H69R, T74S	B
	48-3309	3309-30902	DQ878213	PI	NA	I47V, G48MV, I54V, V82C, L90M	L33F, K43T, G73AT, L89V	L10IV, E35D, M36I, Q61QE, I62V, L63P, A71T, I72IT, I93L	B
	48-4071	4071-30218	DQ878300	PI	NA	V32I, M46I, I47V, I54V, V82C, L90M	L10F, V11VI, F53L	K14R, I15V, I62V, L63P, A71V, I72L, I85V	B
	48-4096	4096-30422	DQ878326	PI	NA	M46L, I54V, V82C, I84V, L90M	L10F, V11VI, L33F, G73S	T4TA, L19LI, E34Q, Q61H, I62V, L63P, A71V, V77VI, P79D	B
	48-4245	4245-30513	DQ878476	PI	NA	M46I, I54V, V82C, I84V, L90M	G73S	L10I, N37D, K55R, R57RK, L63P, I66IV, A71V	B
	48-4279	4279-30919	DQ878503	PI	NA	I54V, V82C, I84V, L90M	L10F, L33F, F53L, T74P	K14R, E34Q, N37D, R41K, K55R, Q61E, I62V, L63P, A71V, V77I, P79D, I93L	B
	48-6014	6014-30313	DQ878611	PI	NA	M46L, I54V, V82C, I84V	L24I, L33F, K43T, T74P	L10I, I13V, I15IV, K20R, E35D, M36I, N37D, L63P, I72V, T91TS	B
	48-6017	6017-30320	DQ878616	PI	NA	M46I, I54V, L76V, V82C, L90M	L10F	T12S, I13M, I15V, L19Q, K20I, M36I, N37D, K55R, I62IV, L63P, H69K, A71V, I93L	B
	48-6045	6045-30515	DQ878644	PI	NA	V32I, M46I, I47V, V82C, L90M	G73S	I15V, K20T, E35D, N37T, I62V, L63P, A71V, V77I, C95L	B
	48-6083	6083-30521	DQ878678	PI	NA	M46I, I54V, V82C, I84V, L90M	L10F, V11I, K43T, G73T	I13V, I15V, K20I, L24M, M36I, L63P, C67Y, H69R, A71V	B
	48-6085	6085-30526	DQ878680	PI	NA	G48M, I54V, V82C, L90M	F53L, G73S	L10I, I13V, I15V, K20T, E34EQ, M36I, N37ND, Q61QE, I62V, L63P, A71V, C95L	B
	48-6198	6198-30728	DQ878770	PI	NA	G48V, I54V, V82C, L90M	L33F, G73S	L10I, T12V, G16A, R57K, I62V, L63P, A71V, I72L, V77VI, I93L	B
	48-6202	6202-30729	DQ878774	PI	NA	M46I, I54V, V82C, L90M	G73S	L10V, I13V, I15V, L19I, K20T, I62V, L63P, A71T	B
		6202-40421	DQ878775	PI, RTV, TPV	>38	M46I, I54V, V82C, I84V	G73S	L10V, I13V, I15V, L19I, K20T, M36I, I62V, L63P, A71T	B
	48-6258	6258-30902	DQ878815	PI	NA	M46I, I50IV, I54V, V82C, L90M	L10F, G73A	I13IV, Q18QH, L19LP, K20I, M36MI, N37D, L63P, I66IF, C67FY, H69K, A71T, I72R, I93L	B
	48-6377	6377-30930	DQ878887	PI	NA	M46L, I54V, L76V, V82C, L90M	F53L	L10V, I15V, G16A, R41N, L63P, H69K, A71V	B
	48-7081	7081-30910	DQ878936	PI	NA	I54V, V82C, I84V, L90M	L10F, Q58E, G73T	I62IV, L63P, A71V, I93L	B
	48-7105	7105-30910	DQ878959	PI	NA	M46I, I50V, I54V, V82C	V11VI, L33F, Q58E	L10I, K20R, E35D, M36I, K55R, D60E, I62V, L63P, I64L, A71V, I85V, L89M	B
	48-7142	7142-30731	DQ878980	PI	NA	M46L, G48V, I54V, V82C, I84V, L90M	L33F, Q58E	L10I, G16GAE, N37C, I62V, L63PS, A71V, I72IK, I93L	B
	48-9061	9061-30820	DQ877475	PI	NA	M46I, I54V, V82C, I84V	L10F, L24I, L33F	L63P, A71I, I72T, P79N, T91S, I93L	B
	48-9354	9354-30924	DQ877527	PI	NA	M46I, I54V, V82C, I84V, L90M	L10F, L33F, G73T	I13V, L63P, K70T, A71V, P79A, I93L	B
	48-9309	9309-30918	DQ877568	PI	NA	M46MI, I54AS, V82C	L24I, L33F, K43T	L10I, I13V, I15V, K20R, E35D, M36I, N37D, R41K, I62V, L63P, I64V, A71V, T74S, I85V, I93L	B
	48-9374	9374-30929	DQ877682	PI	NA	M46L, I54ST, V82C, L90M	L10F, L33F, K43T, T74P	I13V, L19T, I62V, L63P, A71T, V77I, L89R, I93L	B
	48-9113	9113-30918	DQ877699	PI	NA	V32I, M46I, I47V, V82C, L90M	L10F, F53FL, G73T	I62V, L63P, V77I, I93L	B
	48-9125	9125-30918	DQ877730	PI	NA	M46L, I54A, V82C, I84V	L24I, L33F, K43T	L10I, L19I, K20R, E34EQ, E35D, M36I, N37S, I62V, L63P, I64V, A71V, Q92K	B
Rhee (2009)	CA37887	CA84415	FJ983564	SQV, RTV	445	I54V, V82C, L90M	F53L	L10LV, K20R, E35D, M36I, R41K, D60E, I62V, L63P, I64L, A71V	B
Dau (2010)	06682A	06682A	GU581765	PI	NA	M46L, I54V, V82C, I84V, L90M	L33F	L10I, L63P, A71V, V77I, I93L	B
	06928A	06928A	GU581800	PI	NA	I54V, V82C, I84V, L90M	V11VI, L33F, K43T, G73T, L89V	L10I, I13V, K20R, E35D, M36I, N37D, I62V, L63P, A71T, P79S	B
	07783A	07783A	GU581869	PI	NA	M46I, I54V, V82C, L90M	G73S	L10I, K20I, M36I, I62IV, L63P, I66F, C67CY, A71V, I93L	B
	10498A	10498A	GU582003	PI	NA	I54V, V82C, I84V	K43KT	L10I, I13V, L19I, K20R, E35D, M36I, N37D, R41RK, D60E, Q61E, L63P, A71AV, L89LM, I93L	B
	11917A	11917A	GU582055	PI	NA	I54V, V82C		L10I, N37NSTY, I62V, L63HP, A71AV, I93L	B
Rhee (2010)	CA25655	CA84315	GQ213176	PI, Unknown, RTV, FPV	>74	M46ML, I54V, V82C, L90M	L10F, L33F, G73S, L89V	I13IV, N37S, R41K, K43R, K55R, R57K, I62V, L63P, I64IM, A71V, I93L	B
Barber (2012)	56069	56069	JQ361666	LPV		M46I, I54V, L76V, V82C		L10V, I13V, K14R, L63P, I64V	B
Jones (2012)	135338	135338	JN669541	PI	NA	M46I, I54V, L76V, V82C, L90M	L10FI, Q58E, G73A	I13V, Q18H, K20I, M36MI, K55R, I62V, L63P, I64V, C67CF, K70R, A71V, I72L	B
	142746	142746	JN669624	PI	NA	M46I, I54V, L76V, V82C, L90M	L10F, Q58E, G73A	I13V, Q18H, K20I, M36I, K55R, I62V, L63P, I64V, K70R, A71V, I72L	B
	149974	149974	JN669742	PI	NA	M46I, I54V, V82C, L90M	L10F, K43KT, N88D	K14GR, I15V, K20I, R41K, I62V, L63P, A71V, I72L, V77I, I85V	B
	185252	185252	JN670699	PI	NA	I54V, V82C	L33F	T12K, I13V, K14N, G16A, Q18H, L19I, K20KR, M36I, I62IV, L63C, I72IV, T74A, L89M	B
	194881	194881	JN670954	PI	NA	M46I, I54V, V82C, L90M	K43T	I15V, K20IV, N37NS, R41RK, I62V, L63P, C67F, A71V, I72R, V77I, I85V, N88E	B

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