Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	B
Gene	PR
Mutation	T74P
Rx	>= 1 PI
IncludeMixtures	No

References	26
Patients	158
Isolates	181

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Patick (1998)	510-35	510-35W14		NFV	14	M46I	T74P	T12K, I15V, L19I, M36I, N37S, R41K, D60E, I62V	B
Cabana (1999)	Cab-l	L47	AF102330	RTV, SQV	92	M46I, I84V, L90M	L33F, F53L, T74P	E34Q, N37H, R41K, I62V, L63P, I72L, G73V, V77I	B
Gatanaga (1999)	Gat-NR4	agaNR4	AB020919	SQV, NFV	64	M46I, I84V, L90M	T74P	L10I, R41K, I62V, L63P, A71V, V77I, I93L	B
Zolopa (1999)	CA1159	CA24139	AY798347	IDV, SQV, RTV	256	M46IV, V82T, I84V	T74P	L10Y, I15V, L19LI, K20M, K55N, D60E, L63P, H69R, K70T, L89M	B
Atkinson (2000)	BA1	BA1_v3	AF247884	NFV	34		T74P	I13V, L19V, L63P	B
Balotta (2000)	CB-128	CB-128	AF251999	RTV, IDV		I54V, V82S	L33F, T74P	I13V, N37D, L63P, C67Y, H69K, A71V, V77I	B
Belec (2000)	nr72	nr72_m12	AF204393	IDV	52	M46I, I84V, N88S	T74P	L10I, E35D, N37H, R41K, R57K, Y59F, L63P, A71V, I72V, V77I, I93L	B
Sevin (2000)	SA-630474a	SA-630474a	AF226148	SQV	105	L90M	T74P	L10I, M36MI, I62V, L63P, A71V, I93L	B
Brun (2001)	SB-PtB	SB-PtB-BL		SQV		I84V, L90M	T74P	L10X, E35D, N37D, L63P, A71V, I93L	B
		SB-PtB-w36		SQV, LPV	36	I84V, L90M	L10F, T74P	E35D, N37D, L63P, A71V, I93L	B
		SB-PtB-w48		SQV, LPV	48	M46I, I84V, L90M	L10F, T74P	T4A, E35D, N37E, L63P, K70R, A71V, I93L	B
Gonzales (2001)	CA1581	CA4511	AY030680	SQV, IDV, NFV, RTV	153	M46I, I84V	L24I, T74P	L10I, K43R, D60E, I62V, L63Q, I64V, H69R, A71V, V77I, I93L	B
	CA3914	CA9457	AY030917	NFV	77	M46I	L33I, T74P	L10LI, R41K, I62V, L63P, A71T, I72V, V77I, I93L	B
	CA5755	CA14294	AY032145	NFV	100	M46I, L90M	T74P	K43R, I62V, L63P, A71V, I72T, V77I, Q92QR, I93L	B
Kempf (2001)	DK-5204	DK-5204		SQV	57	I84V, L90M	L10F, T74P	E35D, L63P, A71V, I93L	B
		8347_d253		SQV, LPV	93	I84V, L90M	L10F, T74P	E35D, N37D, L63P, A71V, I93L	B
		8347_d341		SQV, LPV	105	M46I, I84V, L90M	L10F, T74P	T4TA, E35ED, N37D, L63P, K70KR, A71V, I93L	B
		8347_d763		SQV, LPV	166	M46I, I54V, I84V, L90M	L10FI, L33LF, T74P	E35D, M36MI, N37D, L63P, A71V, I93L	B
		8347_d922		SQV, LPV	188	M46I, I54V, I84V, L90M	L10F, L33F, T74P	N37D, L63P, A71V, I93L	B
		8347_d1170		SQV, LPV	224	M46I, I54V, I84V, L90M	L33F, T74P	L10I, L63P, A71V, I93L	B
	DK-6215	DK-6215		SQV, RTV	258	M46MI, L90M	F53L, T74P	K14R, L19T, K20M, E35EG, M36I, I62V, L63P, A71T, Q92K	B
	DK-8284	DK-8284		SQV, IDV, NFV	149	M46I, I84IV, L90LM	T74P	L10I, I13V, L19I, E35D, M36I, R41K, I62V, I64V, H69K, N88Y, L89M	B
Kantor (2002)	CA597	CA11230	AY047372	SQV, IDV	63	L90M	T74P	L10I, K20R, M36I, N37D, L38I, I62V, L63P, A71V, I93L	B
	CA1492	CA11757	AY047432	IDV, SQV, NFV	130	L90M	T74P	I15V, K43R, Q61E, I62V, L63P, I72V, I93L	B
	CA3914	CA20474	AY047453	NFV, APV	185	M46I, L90M	L33I, T74P	L10LI, R41RK, I62V, L63P, H69HY, A71T, I72V, V77I, I93L	B
Margot (2002)	MM-214336565	2143365651		PI	NA	M46L, V82A	L10F, T74P	I62V, L63P, L89M	B
Tural (2002)	20619	20619		IDV, SQV, RTV, NFV	92	M46I, I54V, V82T, I84V	L24I, K43T, T74P	L10I, E35D, M36I, N37D, L63P, A71V, I93L	B
	368428	368428		IDV, SQV, RTV	195	M46I, I84V, L90M	T74P	L10I, K14R, E35D, N37D, D60E, I62V, L63P, A71I, V77I, I93L	B
	880906	880906		SQV, IDV, NFV	138	M46I, I84V, L90M	T74P	L10I, I13V, I15V, K20M, M36I, D60E, I62V, L63P, A71I, R87S, I93L	B
Saah (2003)	AS-38	AS-38		NFV	33	M46L	L10F, T74P	T12I, I15V, L19T, L63T, I72V	B
Wu (2003)	CA1480	CA9765	AF544486	IDV, SQV, NFV, RTV	126	M46I, I84V, L90M	F53FL, Q58E, T74P	L10I, K20M, E35ED, M36I, R41K, K55R, I62V, L63A, A71V, I93L	B
	CA1492	CA13222	AF544489	IDV, SQV, NFV	147	M46I, L90M	T74P	R8RG, I15V, D25DV, A28AP, K43R, Q61E, I62V, L63P, I72V, I93L	B
Gomez-Carrillo (2004)	98272	98272	AY365573	PI	NA	I54V, I84V, L90M	L33F, T74P	L10I, L19V, I62V, L63P, H69Q, A71V, T91S	B
	110073	110073	AY365830	PI	NA	M46I, I84IV, L90M	G73GC, T74P	L10LI, K14R, I15V, K20I, M36I, I62V, L63Q, I64V, A71V, I72V, I93L	B
	114723	114723	AY365910	PI	NA	I84V, L90M	L10F, T74P	I13V, I15V, K20I, E35EG, M36I, K55KR, I62V, L63P, A71V	B
Garcia-Bujalance (2005)	GBS_25	GBS_25	AY872306	SQV, NFV, LPV		V32I, M46I, I54V, V82A, I84V, L90M	V11VI, L33F, K43T, T74P	L10I, I13V, I15V, Q18H, L19I, K20R, E35D, M36I, K55N, I62V, L63P, I64V, A71V, Q92R	B
Rhee (2005)	CA597	CA20608	AY796435	SQV, IDV, RTV	114	L90M	T74P	L10I, K20R, M36I, N37D, L38I, I62V, L63P, A71V, I93L	B
	CA1159	CA42689	AY796535	IDV, SQV, RTV, LPV, Unknown	>332	M46I, V82IT, I84V	T74P	L10Y, I15V, L19I, K20R, M36MI, K55N, D60E, L63PST, H69R, K70T, L89M	B
	CA1161	CA23194	AY796540	SQV, RTV, IDV, NFV, APV, LPV	254	V32I, M46I, I47V, I54L, I84V, L90M	L33F, K43T, F53L, T74P	E34Q, M36L, I62V, L63A, A71V, I93L	B
	CA1461	CA17537	AY796709	SQV, IDV, RTV, NFV	250	M46I, I84V, L90M	L10F, L33F, F53L, T74P	G16A, I62V, L63P, A71V, V77I, I93L	B
		CA20335	AY798418	SQV, IDV, RTV, NFV	250	M46I, I84V, L90M	L10F, L33F, F53L, T74P	G16A, I62V, L63P, A71V, V77I, I93L	B
	CA1855	CA48127	AY796843	Unknown, NFV, SQV, RTV, APV, LPV	>227	M46L, I54V, V82A, I84V, L90M	L33F, T74P	L10I, I13V, N37D, D60E, L63P, A71V, V77I, I93L	B
	CA3914	CA17503	AY796945	NFV	168	M46I, L90M	L33I, T74P	R41K, I62V, L63P, H69HY, A71T, I72V, V77I, I93L	B
	CA3972	CA42601	AY796969	IDV, SQV, NFV, RTV, APV, ATV	470	M46I, L90M	L10FI, V11VI, G73S, T74P	I13IV, K20I, L33LV, E35D, M36MIV, I62V, L63P, A71V, I93L	B
	CA4465	CA14941	AY797107	Unknown, SQV, NFV, RTV, APV	>90	M46L, I54V, V82A, L90M	T74P	L10I, K20R, E35D, M36I, N37D, R41K, Q61N, I62V, L63X, I64M, A71V, I93L	B
	CA5111	CA37930	AY797234	IDV, SQV, RTV, APV, LPV	317	G48L, I54T, V82A, I84V, L90M	L33F, K43T, T74P	L10I, I13V, K20R, E34Q, E35D, M36I, N37S, R41K, I62V, L63P, I64V, A71T, I93L	B
	CA5755	CA33455	AY797361	NFV, Unknown	>100	M46I, L90M	T74P	K43S, I62V, L63P, A71V, I72T, V77I, Q92R, I93L	B
	CA8334	CA37793	AY797705	SQV, RTV, APV	374	M46I, I50V, L90M	K43T, F53L, T74P	L10I, I15V, K20I, M36I, D60E, I62V, L63P, A71V	B
	CA8341	CA21259	AY797707	Unknown, NFV	>4	M46I, I84V, L90LM	L10F, T74P	K55KR, D60E, I62IV, L63P	B
Baxter (2006)	12-1645	1645-30313	DQ875952	PI	NA	M46L, I54L, V82A, I84V, L90M	L33F, K43T, T74P	L10V, V11VL, I13V, K20R, E34DY, E35D, M36I, N37D, R41RK, K55R, R57K, I62V, L63P, A71V, I93L	B
	12-1150	1150-30408	DQ876034	PI	NA	I54L, V82A, I84V, L90M	L33F, K43T, T74P	L10I, I13V, E35D, M36IL, N37ND, I62V, L63P, A71V, I72V, I93L	B
	12-1495	1495-30527	DQ876046	PI	NA	M46L, I54V, V82C, I84V	L24I, V32V_F, T74P	L10I, I13V, K14KR, L19LI, M36L, R41K, K55R, I62V, L63P, L89M	B
	12-1686	1686-30401	DQ876062	PI	NA	V32I, I54V, I84V, L90M	L10F, L33F, K43KT, T74P	V11VL, T12K, K14R, I15V, K20T, E34N, M36I, R41K, I62V, L63P, A71V	B
	12-1261	1261-30320	DQ876085	PI	NA	M46L, I54V, V82C, I84V, L90M	L10F, L33F, F53L, T74P	I13V, K55R, D60E, I62V, L63P, I66F, A71V, I72V, T91TS	B
		1261-30417	DQ877129	PI, RTV, TPV	>4	M46L, I54V, V82C, I84V, L90M	L10F, L33F, F53L, T74P	I13V, K55R, D60E, I62V, L63P, I66F, A71V, I72V, T91S	B
	12-3006	3006-30219	DQ876098	PI	NA	V32I, M46I, I47IV, I54L, I84V, L90M	L10F, L33F, K43T, G73AITV, T74P	I13V, L19I, K20KR, E35D, M36MI, N37E, K55R, R57K, I62V, L63P, K70R, A71AV, V77VI, I85IL	B
	12-4010	4010-30130	DQ876166	PI	NA	M46I, V82T, I84V	L10F, T74P	I15V, K20R, M36I, I62V, L63P, A71V	B
	12-4011	4011-30130	DQ876167	PI	NA	V32I, M46MI, I47V, I54L, I84V, L90M	L33F, K43T, T74P	L10I, I13V, K20KR, E35ED, M36MIL, K55KR, I62V, L63P, A71V, G73GV, P79PS, I93L	B
	12-1475	1475-30723	DQ876186	PI	NA	M46I, I84V, L90M	L10F, D30Y, L33F, Q58E, T74P	I13V, I62V, L63P, A71V, V77I, P79D, I93L	B
	12-1648	1648-30424	DQ876201	PI	NA	M46I, I50V, I54V, V82A, L90M	L33F, K43T, F53L, T74P	L10I, I13V, K20R, E35D, M36I, N37T, K55R, R57K, I62V, L63P, A71IV	B
	12-1022	1022-30317	DQ876261	PI	NA	M46L, I54V, V82A, L90M	L10F, L33F, K43T, T74P	I13V, E35D, M36I, I62V, L63P, A71V, I72V, I93L	B
	12-1028	1028-30325	DQ876286	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	V11I, L33F, G73GCFV, T74P, L89AV	L10I, T12P, G16A, K20IV, E34EA, M36MI, R41K, Q61D, I62V, L63P, C67Y, A71V, I72L, V77I, I93L	B
	12-1054	1054-30410	DQ876311	PI	NA	M46L, I54V, V82A, I84V, L90M	L33F, K43T, T74P	L10I, I13V, K20R, E35D, M36I, N37D, K55R, I62V, L63P, A71V, I72IMV, I93L	B
	12-1975	1975-30520	DQ876314	PI	NA	M46I, I84V, L90M	T74P	L10V, L19I, M36I, N37D, I62V, L63P, A71V, I93L	B
	12-2376	2376-30821	DQ876348	PI	NA	M46I, I50L, I54V, V82L, L90M	L33F, G73C, T74P	L10I, V11L, I13V, G16A, K20R, E35D, M36I, N37D, R41K, I62V, L63P, A71V, L89A, I93L	B
	12-1078	1078-30409	DQ876401	PI	NA	V32I, M46L, I54V, V82A, L90M	L33F, T74P	L10I, I13V, G16A, K20R, L24F, M36I, K55R, I62V, L63P, I66V, G73V, I85L	B
	12-1932	1932-30513	DQ876428	PI	NA	M46L, I54V, I84V, L90M	L10F, L33F, Q58QE, T74P	I13V, K14R, E35D, M36I, I62V, L63P, I64V, Q92K	B
	12-1342	1342-30423	DQ876445	PI	NA	M46L, I54V, I84V, L90M	L10F, L33F, K43T, T74P	I13V, E34Q, M36MI, L63T, A71V, I72V, T91S, I93L	B
	12-1811	1811-30513	DQ876448	PI	NA	M46L, G48V, I54V, V82S, I84V	L33F, T74P	L10I, I13V, G16E, K55R, L63T, V77I	B
	12-2347	2347-30806	DQ876461	PI	NA	M46I, I54L, I84V, L90M	L33F, T74P	L10I, I13V, E35D, N37P, R41K, I62V, L63LP, A71V, V77I, I93L	B
	12-1344	1344-30430	DQ876465	PI	NA	G48L, I54T, V82A, I84V, L90M	L33F, K43T, T74P	L10I, I13V, K20R, E34Q, E35D, M36I, N37S, R41K, I62V, L63P, I64V, A71T, I93L	B
	12-1360	1360-30813	DQ876499	PI	NA	V32VI, M46L, I54V, I84V	L33F, T74P	L10IV, T12TP, I13V, I15V, K20R, E35ED, M36I, R41K, I62V, L63P, I64V, A71AV	B
	12-2139	2139-30818	DQ876544	PI	NA	M46L, V82VA, I84V, L90M	L33F, F53L, T74P	L5V, L10I, I13V, N37D, R41K, I62IV, L63P, A71V, I72IV, I93M	B
	12-2257	2257-30818	DQ876574	PI	NA	I54L, I84V, L90M	L33F, T74P	L10I, V11L, I13V, K20R, E34Q, E35D, M36I, N37D, D60E, I62V, L63P, A71V, I93L	B
	12-1842	1842-30731	DQ876592	PI	NA	I54L, V82A, I84V, L90M	L33F, T74P	L10I, I13V, G16A, K20R, E34Q, M36I, N37D, R41K, I62V, L63P, A71V, I72T, I93L	B
	12-2232	2232-30715	DQ876607	PI	NA	M46I, I54V, V82A, L90M	T74P	L10I, I13V, K14KR, I15V, Q18K, K20I, M36I, R41K, K55KR, D60E, Q61D, L63P, A71V, I93L	B
	12-1762	1762-30417	DQ876621	PI	NA	M46L, I54V, V82C, I84V, L90M	V11VI, L33F, T74P	L10I, I13V, R41K, I62V, L63P, A71T, L89R, I93L	B
	12-2155	2155-30721	DQ876685	PI	NA	I54V, I84V	L10F, V11I, L33F, T74P	I13V, I15V, K20T, E35D, M36I, R41K, K55R, I62V, L63P, L89T	B
	12-2342	2342-30730	DQ876709	PI	NA	M46I, I54V, V82A, L90LM	L10F, L33F, T74P	I13V, I15V, G16E, L19I, K20T, E35G, M36I, P39T, R41RK, R57K, I62V, L63C, A71V, I72T, I93L	B
	12-3161	3161-30822	DQ876727	PI	NA	M46I, I54V, I84V, L90M	L10F, T74P	T12Q, I13IV, I15IV, L19K, K20I, E34EV, M36MI, R41K, K55R, Q61QH, L63P, A71V, T91S, I93L	B
	12-1404	1404-30424	DQ876787	PI	NA	M46L, I54V, I84V, L90M	G73GS, T74P	L10I, R41K, K55R, I62V, L63P, C67CF, A71V, V77I, L89LM, I93L	B
	12-1412	1412-30821	DQ876795	PI	NA	M46I, I54V, V82ACGS, I84V, L90M	L33F, K43T, G73C, T74P	L10I, K14R, M36L, I62V, L63P, I66F, C67Y, H69HR, I72M, I93L, C95F	B
	12-1128	1128-30311	DQ876824	PI	NA	M46L, I54V, V82A, I84V, L90M	L33F, K43T, T74P	L10I, I13V, K20R, E35D, M36I, N37D, I62IV, L63P, A71V, I93L	B
	12-1135	1135-30512	DQ876828	PI	NA	M46L, I84V, L90M	L33F, G73S, T74P	N37D, I62V, L63P, A71V	B
	12-1471	1471-30424	DQ876876	PI	NA	M46I, I54A, V82VA, I84V, L90M	L10FY, L33F, T74P	Q18H, L19I, K20R, E34Q, E35D, M36I, N37D, I62V, L63P, A71V, I72IT, Q92QK	B
	12-1761	1761-30410	DQ876887	PI	NA	M46I, I54V, V82A, I84V, L90M	V11VIL, L33F, K43T, T74P	L10I, I13V, K20R, E35D, M36I, N37E, K55R, I62V, L63P, A71V, I93L	B
	12-1493	1493-30502	DQ876889	PI	NA	I54V, V82S, L90M	L10FY, L33F, K43T, F53L, T74P	I13V, L19I, K20R, E35D, M36I, N37E, R41K, I62V, L63P, I66F, A71V, I72IV	B
	12-2202	2202-30717	DQ876901	PI	NA	M46I, I54V, I84V, L90M	L10F, T74P	I13V, L33M, K55R, R57K, I62V, L63P, C67CY, L89I, T91S	B
	12-1918	1918-30520	DQ876909	PI	NA	M46I, I50V, I54V, V82A, L90M	L33F, T74P	L10V, I13V, G16A, K55R, Q61E, L63P, A71V, I72V, V77I, I93L	B
	12-2043	2043-30609	DQ876919	PI	NA	G48V, I54T, V82S	L33F, T74P	L10I, I13V, E34Q, N37S, I62V, L63P, A71V, V77I	B
	12-1750	1750-30418	DQ876984	PI	NA	M46L, G48V, V82A	L24I, Q58E, G73A, T74P, L89V	L10IV, L33M, N37D, K55R, I62V, L63P	B
	12-1237	1237-30519	DQ877025	PI	NA	M46I, I50V, I54V, V82A, L90M	L33F, K43T, F53L, T74P	L10IV, I13V, K14R, E21EQ, K55R, D60E, I62V, L63P, A71V, V77I	B
	12-1940	1940-30521	DQ877026	PI	NA	M46L, I54V, I84V, L90M	L33F, T74P	L10I, V11L, I13V, R41K, K55KR, D60E, L63P, A71V, V77VI, I93L	B
	12-2475	2475-30819	DQ877040	PI	NA	M46L, I54V, V82A, I84V, L90M	L33F, K43T, T74P	L10V, I13V, K20R, E35D, M36I, L63P, K70KT, A71V, I72V, I93L	B
	12-1546	1546-30424	DQ877047	PI	NA	M46L, G48GA, I54V, V82A	L24I, L33F, K43T, T74P	L10I, I13V, K20R, E35D, M36I, N37T, K55R, R57K, I62V, L63P, A71IV, I93L	B
	12-1652	1652-30328	DQ877088	PI	NA	M46I, I47V, I54M, I84V, L90M	L10F, T74P	I13M, K20I, E34Q, M36MI, R57RK, I62IV, L63P, I64V, I66IV, G73V, I93L	B
	12-1577	1577-30507	DQ877104	PI	NA	M46I, I54V, I84V, L90M	L10F, L33F, F53L, T74P, L89V	I13V, K20R, E35D, M36I, G51A, I62V, K70E, A71V, G73V	B
	12-3071	3071-30514	DQ877209	PI	NA	M46I, I84V, L90M	L10F, Q58E, T74P	I13V, L19I, L63P, A71V, V77VI, I93L	B
		3071-31002	DQ879130	PI, RTV, TPV	>20	M46L, I54V, I84V, L90M	L33F, Q58E, T74P	I13V, L19I, K45R, L63P, A71V, V77I, I93L	B
		3071-40708	DQ879129	PI, RTV, TPV	>60	M46L, I54V, V82C, I84V, L90M	L33F, Q58E, T74P	I13V, L19I, K45R, L63P, A71V, V77I, I93L	B
	12-3024	3024-30306	DQ877237	PI	NA	M46I, I54V, V82A, I84V, L90M	L33F, T74P	L10I, V11L, I13V, N37D, R41K, I62V, L63P, A71V, I72V, V77VI, I93L	B
	48-1004	1004-30609	DQ877311	PI	NA		T74P	I15V, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, I72T	B
	48-1026	1026-30623	DQ877404	PI	NA	M46I, V82C, I84V	L24I, Q58E, T74P	L10I, I15V, L19T, K55R, L63P, A71AV, I72IR, V77I	B
	48-1228	1228-30417	DQ877761	PI	NA	V32I, I47V, I54M, I84V, L90M	L33F, T74P	L10I, I13V, I15V, R41K, K45R, R57K, L63P, A71V, G73V, I93L	B
	48-1422	1422-30311	DQ877811	PI	NA	I54V, V82A, I84V, L90M	L33F, Q58E, T74P	L10I, T12I, I13V, K20R, E34Q, E35D, M36I, N37T, R41K, R57K, I62V, L63P, A71V, I72V, I93L	B
	48-2206	2206-30409	DQ877859	PI	NA	V32VI, I47IV, I54V, I84V	L10F, L33F, T74P	I13V, K45KR, I62V, L63P, I93L	B
	48-3023	3023-30303	DQ877933	PI	NA	M46I, V82C, I84V, L90M	F53L, T74P	L10I, R41K, I62V, L63P, I64V, A71V, V77I, I93L	B
	48-3040	3040-30304	DQ877951	PI	NA	M46I, I54T, V82A	L24I, L33F, K43T, T74P	L10I, I13V, E34Q, N37S, R41K, I62V, L63P, A71V, V77I	B
	48-3044	3044-30306	DQ877956	PI	NA	M46L, I54V, V82A, I84V, L90M	L23I, L33F, Q58E, T74P	L10I, I13V, K14KR, G49GE, L63P, A71V, I93L	B
	48-3121	3121-30514	DQ878029	PI	NA	I54L, V82F, L90M	L33F, K43T, F53L, T74P	L10I, I13V, I15IV, K20R, E35D, M36I, N37E, D60E, I62IV, L63PT, I64V, C67Y	B
	48-3125	3125-30410	DQ878033	PI	NA	M46I, V82A, I84V, L90M	L10F, L33F, Q58E, T74P	I13V, I62IV, L63P, A71V, V77I, I93L	B
	48-3215	3215-30514	DQ878125	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	L10F, L33F, F53L, T74P, L89V	I13V, L19V, K20R, E35D, M36I, N37D, L63C, I66F, A71V	B
	48-3225	3225-30521	DQ878132	PI	NA	M46L, I54V, V82A, L90M	L23I, L33F, K43T, F53L, T74P	L10I, I13V, L19I, K20R, E35D, M36I, N37T, K55R, I62V, L63T, C67E, I72T, L89M	B
	48-3261	3261-30728	DQ878165	PI	NA	I54V, V82F	K43T, T74P	L10I, I13V, I15V, L19I, K20T, E35N, M36I, N37S, I62V, L63V, I64V	B
	48-3265	3265-30711	DQ878170	PI	NA	V32I, M46I, I47V, I54L, I84V	L33F, T74P	L10I, I13V, K14R, K20R, E35D, Q61D, L63V, I64V, I66F, H69V, V77L, T91S	B
	48-4003	4003-30314	DQ878236	PI	NA	M46I, I54V, I84V, L90M	L33F, F53L, T74P	L10I, K20R, E34T, E35D, M36I, N37D, R57K, I62V, L63P, A71V, I93L	B
	48-4025	4025-30318	DQ878259	PI	NA	I54V, V82T, I84V, L90M	L33F, T74P	L10I, I13V, K20R, M36I, I62V, L63P, I64M, A71V, I93L, C95F	B
	48-4026	4026-30318	DQ878260	PI	NA	M46I, I54V, V82T, I84V, L90M	L10F, L33F, K43T, G73S, T74P, L89V	G16E, N37D, G40G_KR, K55R, I62V, L63H, C67F, H69HR, K70R, A71V	B
	48-4089	4089-30306	DQ878319	PI	NA	V32I, M46L, I54L, I84V, L90M	V11I, L33F, K43T, G73S, T74P, L89V	L5F, L10I, I13V, E34Q, L63P, A71V, V77I, I93L	B
	48-4120	4120-30403	DQ878351	PI	NA	M46L, I54V, V82A, L90M	L33F, K43T, F53L, T74P	L10I, I13V, L24F, I62V, L63P, A71V, V77I, I93L	B
	48-4129	4129-30318	DQ878360	PI, RTV, TPV	>1	V32I, M46I, I47V, I54L, I84V, L90M	L33F, F53FL, Q58E, T74P	L10I, V11L, I13V, K20R, E34Q, E35D, M36I, R41Q, K55KR, L63P, A71V, I72V, V77I, I93L	B
	48-4146	4146-30324	DQ878378	PI	NA	M46L, I54V, I84V, L90M	L33F, T74P, L89LV	T4TA, L10I, I13V, K20T, E34Q, E35D, M36I, R41K, I62V, L63P, A71T, I72IL, I85V, Q92K, I93L, C95CF	B
	48-4163	4163-30403	DQ878396	PI	NA	M46I, I54V, I84V, L90M	L33I, Q58E, T74P	L10I, V11L, I13V, Q18H, A22V, E35D, M36I, N37D, I62V, L63P, H69R, A71V, Q92K	B
	48-4238	4238-30513	DQ878469	PI	NA	M46L, I54L, V82A, L90M	L33F, K43T, F53L, T74P	L10V, I13V, L19I, K20R, E35D, M36I, N37D, K55R, I62V, L63P, A71V, I93L	B
	48-4240	4240-30513	DQ878471	PI	NA	M46L, I54L, V82A, L90M	L33F, K43T, F53L, T74P	L10V, I13V, L19LI, K20R, E35D, M36I, N37D, K55R, I62V, L63P, A71V, I93L	B
	48-4249	4249-30721	DQ878482	PI	NA	M46L, I54V, V82A	K43T, T74P	L10V, I13V, I15V, L19V, K20M, E35D, M36I, N37NK, R41K, I62V, L63Q, I64V, L89M	B
	48-4279	4279-30919	DQ878503	PI	NA	I54V, V82C, I84V, L90M	L10F, L33F, F53L, T74P	K14R, E34Q, N37D, R41K, K55R, Q61E, I62V, L63P, A71V, V77I, P79D, I93L	B
	48-4295	4295-30722	DQ878517	PI	NA	M46L, I54V, I84V, L90M	L10F, V11I, L33F, T74P	I13V, K20T, E35N, M36I, N37D, K55R, I62V, L63P, A71V, T91S, C95C*	B
	48-5018	5018-30606	DQ878553	PI	NA	M46L, I54IV, I84V, L90M	L10FI, L33F, F53FL, T74P, L89LV	I13V, L19LI, N37HY, K55R, D60E, I62V, L63P, I66F, H69I, A71T, I72E, V77I, Q92K	B
	48-5046	5046-30424	DQ878568	PI	NA	M46I, I54V, V82S	L24I, T74P	L10I, T12P, K14R, K20M, R41K, Q61N, I62V, L63PQ, I64V, E65D, A71V, I72V, V77I, I93L	B
	48-6014	6014-30313	DQ878611	PI	NA	M46L, I54V, V82C, I84V	L24I, L33F, K43T, T74P	L10I, I13V, I15IV, K20R, E35D, M36I, N37D, L63P, I72V, T91TS	B
	48-6141	6141-30909	DQ878722	PI	NA	M46I, I47V, I54V, I84V, L90M	V11I, T74P, L89V	L10I, I15V, G16AE, L19P, K20IV, M36I, R41K, I62V, L63H, H69R, K70E, I72V, G73V, I85V	B
	48-6212	6212-30904	DQ878785	PI	NA	M46I, G48V, I54S, V82A, I84IV, L90LM	L33F, K43T, T74P	L10I, I13V, K20R, E34Q, M36I, I62V, L63P, H69K, A71V, I93M	B
	48-7086	7086-30612	DQ878940	PI	NA	I54V, V82A, L90M	L33F, K43T, F53L, T74P	L10V, I13V, K20R, E35D, M36I, N37E, K55R, R57K, I62V, L63A, A71V, I72V, V77I, T91S	B
	48-7095	7095-30930	DQ878949	PI	NA	M46I, I54V, I84V	L24I, L33F, T74P	L10I, T12P, K20T, E35D, M36I, N37Q, R57K, L63P, A71V, V77I, I93L	B
	48-7162	7162-30609	DQ879000	PI	NA	V32I, M46I, I54V, V82A, L90M	L33F, F53L, T74P	L10I, I13V, K43I, K55R, L63C, A71V, T91S	B
	48-7166	7166-30611	DQ879003	PI	NA	M46I, I47V, I54V, V82A, L90M	K43T, F53L, T74P	L10I, I15V, L19I, K20R, E35D, M36I, R41K, I62V, L63P, H69HR, A71V, I93L	B
	48-9182	9182-30901	DQ877535	PI	NA	M46I, I54A, I84V, L90M	L10F, L33F, Q58E, T74P	T12K, I13V, I15V, K20T, E35G, M36L, R41K, I62V, L63Q, I64V, A71V, L89M, I93L	B
	48-9240	9240-30915	DQ877540	PI	NA	I54V, I84V, L90M	L10F, V11I, L33F, T74P	I13V, K20T, E35D, M36I, N37E, R57K, Q61N, I62V, L63P, A71V, I72M	B
	48-9255	9255-30911	DQ877606	PI	NA	M46I, I47V, I54L, I84V, L90M	L10F, L33F, K43KT, T74P	V11L, I13V, E34Q, I62V, L63P, H69R, A71V, I72V, V77VI, I93L	B
	48-9089	9089-30827	DQ877654	PI	NA	M46I, V82F, I84V, L90M	L33F, K43T, T74P	L10I, I13V, L19I, M36L, N37ND, I62V, I64V, I72V, I93L	B
	48-9374	9374-30929	DQ877682	PI	NA	M46L, I54ST, V82C, L90M	L10F, L33F, K43T, T74P	I13V, L19T, I62V, L63P, A71T, V77I, L89R, I93L	B
	48-9115	9115-30924	DQ877706	PI	NA	M46I, V82A, I84V	L33F, Q58E, T74P	L10V, I13V, K20R, M36I, N37D, R41RK, I62V, L63T, I64V, E65D	B
	48-9044	9044-30925	DQ877737	PI	NA	M46I, I54IV, V82F, I84V	L33F, T74P	L10I, I15V, G16E, Q18R, L19P, K20L, N37S, I62IV, V77VI, I85V, L89M	B
	48-8008	8008-30715	DQ879053	PI	NA	M46I, G48A, I50V, I54V, V82A	L33F, F53L, Q58QE, T74P	L10I, L19I, E34Q, I62V, L63P, A71V, I93L	B
	48-8024	8024-30815	DQ879066	PI	NA	V32I, M46I, I47V, I54V, V82A, L90M	L33F, K43T, F53L, T74P	L10V, I13V, K20R, E35D, M36I, R41K, K55R, I62V, L63P, A71V	B
De Meyer (2009)	DRV03	DRV03-48w		PI, DRV, RTV	>48	V32I, I54L, I84V	L10F, V11I, L33F, Q58E, T74P	I13V, L63P	B
	DRV05	DRV05-48w		PI, DRV, RTV	>48	V32I, I54L, I84V, L90M	L10F, V11I, L33F, F53L, G73S, T74P, L89V	I13V, K20T, M36I, D60E, I62V, L63P, A71V	B
	LPV06	LPV06BL		PI	NA	M46I, I54L, L90M	L33F, T74P	L10I, I13V, D60E, I62V, L63P, I64L, V77I, I85V, I93L	B
		LPV06-48w		PI, LPV	>48	M46I, I54L, L76V, L90M	L33F, T74P	L10I, I13V, D60E, I62V, L63P, I64V, V77I, I85V, I93L	B
	LPV24	LPV24BL		PI	NA	M46L, V82A, L90M	F53L, T74P	L10V, K20R, M36I, I62V, L63P, A71V, I93L	B
		LPV24-48w		PI, LPV	>48	M46L, I54V, V82A, L90M	F53L, T74P	L10V, K20R, M36I, I62V, L63P, A71V, I93L	B
	LPV25	LPV25BL		PI	NA	I54V, V82A, L90M	T74P	L10I, K20R, M36I, I62V, I64L, H69K, A71V, I93L	B
		LPV25-48w		PI, LPV	>48	I54V, V82A, L90M	T74P	L10I, K20R, M36I, I62V, I64L, H69K, A71V, I93L	B
Rhee (2009)	CA3914	CA68560	FJ983158	NFV, APV, LPV, RTV, ATV	407	V32VI, M46I, L90M	G73GC, T74P	L10LI, L33M, R41K, K43KR, I62V, L63P, C67CF, A71IT, I72V, V77I, I93L	B
	CA7889	CA20332	FJ983241	IDV, NFV, SQV, RTV, APV	183	M46I, I84V	L10F, L33F, F53L, T74P	L63T, L89M	B
	CA8402	CA68638	FJ983283	IDV, LPV, APV, FPV, RTV, TPV	449	M46L, I54V, V82A, L90M	L33F, T74P	L10I, I13V, N37ND, I62V, L63P, I93L	B
Dau (2010)	06268A	06268A	GU581726	PI	NA	M46L, I54V, V82A, I84V, L90M	V11I, L33F, K43T, T74P	L10I, I13V, K55R, I62IV, L63P, A71V, I72V, V77VI, I93L	B
	06331A	06331A	GU581731	PI	NA	M46I, I54V, V82T, I84V, L90M	L10F, L33F, G73GS, T74P	I13V, G16A, I62V, L63P, A71T, Q92K, I93L, C95F	B
	06692A	06692A	GU581767	PI	NA	I84V, L90M	T74P	I15V, I62V, L63P, A71V, I93L	B
	06833A	06833A	GU581784	PI	NA	I54V, V82A, I84IV, L90M	L33F, K43KT, F53FL, T74P	L10I, I13V, G16A, K20R, E35D, M36I, I62V, L63P, A71V, Q92QK, I93L	B
	07157A	07157A	GU581823	PI	NA	M46L, I54V, V82A, I84V, L90M	L33F, T74P	L10I, I13V, N37D, L63P, A71V	B
	08177A	08177A	GU581899	PI	NA	L90M	T74P	L10I, I62V, L63P, A71V, V77I, I93L	B
	08757A	08757A	GU581943	PI	NA	M46L, I54V, I84V, L90M	K43T, T74P	L10I, G16GA, K20R, E35D, M36V, N37E, I62V, L63P, A71V, Q92QK, I93L	B
	10025A	10025A	GU581992	PI	NA	M46I, I54V, V82A, I84V, L90M	L33F, T74P	L10I, V11L, I13V, N37D, R41K, I62V, L63P, A71V, I72V, V77VI, I93L	B
	10985A	10985A	GU582028	PI	NA	M46MI, L90M	L33LI, Q58E, T74P	L10I, I13IV, I15V, L19V, K20M, M36I, R41K, L63P, A71AT, Q92QR	B
	11057A	11057A	GU582032	PI	NA	V32I, I47IV, I54L, I84V, L90M	L10F, L33F, T74P	I13V, E35ED, M36L, K55KR, I62V, L63P, A71V, I72IM	B
	11677A	11677A	GU582048	PI	NA	M46L, I54V, V82A, I84V	L24I, L33F, K43T, T74P	L10I, I13V, K20R, E35D, M36I, L63P, H69K, L89LM	B
	13335A	13335A	GU582071	PI	NA	M46L, I54V, I84V, L90M	L10F, L33F, T74P	I13V, K20R, E35D, M36I, N37DE, L63P, A71V, I72V, I93L	B
Rangel (2010)	HIV260p	HIV260p	GU807511	PI	NA	M46I, I50V, I54V, I84V, L90M	L10F, L33F, T74P	I13V, E35EK, L63P, K70N, A71T, L89R	B
	HIV249b	HIV249b	GU807507	PI	NA	V32I, I47V, I54L, I84V, L90M	L33F, T74P	L10I, V11L, I13V, G16A, K20R, E35D, M36I, K55N, R57K, I62V, L63P, A71V, I72V, V82I	B
Rhee (2010)	CA3972	CA68568	GQ212298	IDV, SQV, NFV, RTV, APV, ATV, TPV	599	M46I, I54V, V82L, L90M	Q58QE, T74P	L10I, I13V, K20I, L33V, E35D, M36I, N37T, I62V, L63P, I64IV, A71V, I93L	B
	CA8334	CA63821		SQV, RTV, APV, ATV	508	M46I, I50V, I54IL, L90M	L10F, K43T, F53L, T74P	I15V, K20I, M36I, D60E, I62V, L63P, A71V	B
Jones (2012)	133460	133460	JN669525	PI	NA		L10FI, Q58E, T74P	T12S, I15V, L63P	B
	146327	146327	JN669676	PI	NA	I54V, V82A, L90M	L33F, F53L, T74P	L10I, I13V, G16E, L19I, K20R, E35D, M36I, N37D, R41K, I62V, L63H, K70E, A71V, Q92QKR	B
	157897	157897	JN669902	PI	NA	M46L, I54V, I84V, L90M	L33F, Q58E, T74P, L89V	T4TS, L10R, I13V, K14R, K20T, E35D, M36I, I62V, L63P, A71V, I72V, Q92K, I93L	B
	158406	158406	JN669917	PI	NA	I84V, L90M	L10F, T74P	I13V, I15V, K20I, E35G, M36I, I62V, L63P, A71V, I72T, I93M	B
	160597	160597	JN669985	PI	NA	M46I, I54V, V82A, I84V, L90M	L33F, T74P	L10I, I13V, K20KR, M36I, I62V, L63P, H69K, K70T, A71V, T91S	B
	166819	166819	JN670135	PI	NA	M46L, I54L, I84V	L24I, K43T, T74P	L10I, T12P, I15V, G16E, K20R, E35D, M36I, I62V, L63H, I72V, L89M	B
	197471	197471	JN671074	PI	NA	M46I, I84V	L10F, F53L, T74P	I13V, G16E, L19I, K20T, E35D, M36I, P39Q, K55R, R57K, D60E, Q61N, L63T, I64IV, E65D, L89M	B
	199214	199214	JN671155	PI	NA	M46I, I50V, I54V, V82A, L90M	K43T, F53L, T74P	L10V, I13IL, K14KM, K20R, E34R, E35D, M36I, R41K, K55R, R57K, I62V, L63T, I64M, A71V, I72T, I93L	B

Protease Inhibitors

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