<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation T74A
Rx PI-naive
IncludeMixtures No
References 36
Patients 132
Isolates 136
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Hammer (1997)ACTG320_17241724 None   N37D, T74A, V77IB
Craig (1998)Craig-pt2626B None   E35D, N37E, I62V, L63P, T74AB
Bacheler (2000)LB4-P138P138-0 None   I13V, L63P, T74AB
  P138-32 None   I13V, L63P, T74AB
Gonzales (2001)CA6352CA16099AY032311None   E35D, N37H, R41K, Q61E, I62V, I64V, T74AB
Cuevas (2002)CU82CU82AF425463None   L10I, I64V, T74A, I93LB
Gulick (2004)RG489RG489w0 None   K14KR, I15IV, N37D, I62IV, L63P, T74AB
Rhee (2005)CA6352CA23522AY797387None   E35D, N37H, R41K, Q61E, I62V, I64V, T74AB
 CA9968CA24699AY797961None   I13V, M36I, R41K, I62V, L63P, T74AB
 CA16425CA39010AY798250None   I15V, D60E, I62IV, L63T, I72T, T74A, V77IB
Lama (2006)Pt45834583 None   T12P, K14R, L19LI, R41RK, D60DN, Q61E, I62V, L63P, I64IL, I72IV, T74A, V77I, I93LB
 Pt50335033 None   L10V, I13V, L33V, L63T, I72T, T74A, P79Q, L89MB
 Pt60306030 None   L10V, K14KR, L19LI, K43R, T74A, L89MB
Rey (2006)H3680DR_H3680 None   I62V, L63P, T74AB
Valle-Bahena (2006)RT-34PROT-RT-34DQ150710None   I15V, I62V, L63Q, T74AB
Gatanaga (2007)C03-51110017-1C03-51110017-1AB640117None   Q7E, I62V, L63P, T74A, V77IB
 C03-51110030-1C03-51110030-1AB640130None   L10LI, E35D, N37D, I62V, L63P, A71AV, T74A, V77VI, I93LB
 C03-51110053-1C03-51110053-1AB640153None   L10I, I13K, R41K, I62V, L63P, T74A, V77I, I93LB
 C03-51110097-1C03-51110097-1AB640197None   T12P, K14R, I62V, L63PS, A71AV, T74A, V77I, I93LB
 C03-51110112-1C03-51110112-1AB640212None   I15V, E35D, R41K, I62V, L63P, A71V, T74A, I93LB
 C04-51110124-1C04-51110124-1AB640224None   L10I, N37S, I62V, L63T, I72V, T74A, I93LB
 C03-5555-5485-1C03-5555-5485-1AB640383None   L10I, N37S, I62V, L63T, I72V, T74A, I93LB
 C04-5555-5675-1C04-5555-5675-1AB640391None   R41K, I62V, L63P, A71AT, T74A, V77I, I93LB
 C04-5555-5794-1C04-5555-5794-1AB640396None  Q58ET12TAIV, E35D, M36I, R41K, I62V, L63P, A71V, T74A, I93LB
 C04-2066224-1C04-2066224-1AB640490None   L10I, N37S, I62V, L63T, I72V, T74A, I93LB
 H04-201112-1H04-201112-1AB640566None   T12P, I62V, L63P, T74A, I93LB
Holguin (2007)614116614116EF583266None   I13V, I15V, E35D, R41K, R57K, T74A, L89MB
Lin (2007)4V764V76EF078237None   Q7R, I13V, M36L, P39S, R41K, P44S, K45T, R57K, I62V, L63P, C67F, H69Y, K70N, T74A, N83I, Q92H, F99YB
Sanchez Onoro (2007)534657534657 None   R57K, I62V, L63P, T74AB
 614116614116 None   I13V, I15V, E35D, R41K, R57K, T74A, L89MB
Chang (2008)TW4074aTW4074a None   I62V, L63P, T74A, I93LB
Ibe (2008)124124AB356178None   I62V, L63P, T74AB
 143143AB356194None   R41RK, I62V, L63P, T74AB
 157157AB356205None   I62V, L63P, T74A, I93LB
 219219AB356249None   T12A, I62V, L63P, A71V, T74A, V77I, I93LB
 337337AB356334None   T12P, R41RK, I62V, L63P, A71V, T74A, V77I, I93LB
 350350AB356344None   T12P, I62V, L63P, T74A, I93LB
 393393AB356372None   N37NS, P39PL, I62V, L63P, A71V, T74A, V77I, L90LW, I93LB
 434434AB356404None   T12AEPQ, N37ND, R41RK, I62V, L63PT, A71V, T74A, V77VI, I93LB
 445445AB356412None  L33LIP39T, R41K, K43KR, K45KR, I62V, L63P, A71V, T74A, V77I, I93LB
 487487AB356438None   P39T, R41K, I62V, L63P, A71V, T74A, V77VIM, I93LB
 522522AB356461None   E34EG, E35ED, M36ML, P39PT, R41K, W42WC, I62V, L63P, H69HQ, A71V, T74A, V77I, I93LB
 538538AB356472None   T12A, R41K, I62V, L63P, A71V, T74A, V77I, I93LB
Brumme (2009)S1579S1579GQ372152None   M36MT, N37ND, I62V, L63IT, K70KT, I72IV, T74A, V77I, L89LFB
Dumans (2009)35_0535_05FJ405105None   K14R, L19I, N37D, L63S, I64L, H69S, I72T, T74A, N98TB
Fujisaki (2009)607607AB442273None   N37S, I62V, L63P, T74AB
 687687AB442339None   K14KR, I15V, R41K, L63AT, T74A, V77VIB
 694694AB442342None   I15IV, E35D, I62V, L63P, I64V, I72IV, T74AB
 714714AB442357None  Q58QEQ7QE, T12TA, I62V, L63P, A71V, T74A, V77I, I93LB
Machado (2009)P027BRAP027GQ200801None   G40R, R41K, K55I, L63P, T74A, V77I, L97FB
Smith (2009)CR100US2006CR100 None   L10V, I13V, I15V, G16E, K20T, N37S, R41K, R57K, I62V, L63R, I64V, E65D, K70IT, T74A, V77IB
 CR128US2006CR128 None   T12TK, I15V, L19I, E35ED, M36L, N37NS, R41K, I62V, L63P, T74AB
 CR189US2006CR189 None   L10V, I13V, I15V, G16E, K20T, N37S, R41K, K43KR, R57K, I62V, L63R, I64V, E65D, K70IT, T74A, V77IB
Vercauteren (2009)pt19041882156273GQ399120None   M36I, N37NT, R41K, I62V, T74A, L89MB
 pt147s9XIq0VPK3GQ400877None   T12P, I15V, L19T, E35D, N37S, R41K, L63T, A71V, I72T, T74A, I93LB
Hattori (2010)C06-51110328C06-51110328AB864735None   T12A, R41K, D60E, I62V, L63P, K70R, T74AB
 C05-51110247C05-51110247AB864654None   E35D, I62V, L63P, A71V, T74A, V77I, I93LB
 C06-51110350C06-51110350AB864757None   L10I, E35D, R41K, I62V, L63P, T74A, I93LB
 C05-2069073C05-2069073AB867784None   T12A, R41K, D60E, I62V, L63P, K70R, T74AB
 C07-2069081C07-2069081AB868072None   T12A, I62V, L63P, A71V, T74A, V77I, I93LB
 C06-51110346C06-51110346AB864753None   T12A, R41K, D60E, I62V, L63P, K70R, T74AB
 C05-20201736C05-20201736AB863991None   L10I, E35D, R41K, I62V, L63P, T74A, I93LB
 C05-2069126C05-2069126AB867890None   T12A, E35D, N37D, I62V, L63P, A71V, T74A, I93LB
 C05-51110288C05-51110288AB864695None   E35D, N37D, I62V, L63P, A71V, T74A, I93LB
 C05-2069081C05-2069081AB867800None   K14R, R41K, D60E, I62V, L63P, K70R, T74A, I93LB
 C07-2069009C07-2069009AB867999None   N37D, I62V, L63P, T74A, V77I, I93LB
 B05-511019PN235B05-511019PN235AB863884None   L10I, I15V, N37S, I62V, L63T, I72V, T74A, I93LB
 C06-51110409C06-51110409AB864816None   R41K, I62V, L63P, T74A, I93LB
 C06-2066320C06-2066320AB864048None   I15V, E35D, N37D, I62V, L63T, A71V, T74A, V77I, I93LB
 C04-2069045C04-2069045AB867634None   L10I, I62V, L63P, T74A, I93LB
 C05-504605C05-504605AB864584None   I15V, N37S, R41K, I62V, L63T, I72V, T74AB
 C06-2069028C06-2069028AB867948None   Q7E, N37S, Q61E, I62V, L63P, T74A, V77I, I93LB
 C05-2069085C05-2069085AB867808None   E35D, N37D, I62V, L63P, A71V, T74A, I93LB
 C07-51110460C07-51110460AB864867None   N37D, I62V, L63P, T74A, V77I, I93LB
 C05-51110238C05-51110238AB864645None   K14R, R41K, I62V, L63P, A71V, T74A, V77I, I93LB
 C06-51110369C06-51110369AB864776None   K14R, I15V, E35D, N37D, I62V, L63P, A71V, T74A, I93LB
 C07-2066364C07-2066364AB864096None   L10I, I15V, M36I, R41K, I62V, L63P, T74A, I93LB
 C05-2069106C05-2069106AB867850None   T12A, R41K, D60E, I62V, L63P, K70R, T74AB
 F07-5103213F07-5103213AB866461None   T12K, I15V, L19I, M36V, I62V, L63P, T74AB
 C08-51110641C08-51110641AB865048None   Q7E, Q61E, I62V, L63P, A71V, T74A, V77I, I93LB
 C07-51110629C07-51110629AB865036None   Q7E, N37S, Q61E, I62V, L63P, T74A, V77I, I93LB
 C07-51110470C07-51110470AB864877None   R41K, D60E, I62V, L63P, T74AB
 C08-51110686C08-51110686AB865093None   L10I, R57K, I62V, L63P, T74A, V77I, I93LB
 F08-5112152F08-5112152AB866788None   I62V, L63P, T74A, V77I, Q92QKB
 F08-5112170F08-5112170AB866801None   L10I, R41K, I62V, L63P, T74A, V77VI, I93LB
 C07-51110515C07-51110515AB864922None   I15V, R41K, K43R, L63A, T74AB
 C08-2069148C08-2069148AB868296None   K14R, E35D, N37D, I62V, L63P, A71V, T74A, I93LB
 C07-51110626C07-51110626AB865033None   I15V, R41K, L63A, T74AB
 C07-51110475C07-51110475AB864882None   I13V, R41K, D60E, I62V, L63P, K70R, T74AB
 E08-50910732E08-50910732AB865923None   T12TP, L19LI, N37S, R41K, I62V, L63S, I64V, T74A, V77I, I93ILB
 F06-5112046F06-5112046AB866682None   T12AS, M36I, N37ND, I62V, L63P, A71V, T74A, V77I, I93LB
 C08-2069105C08-2069105AB868257None   R41K, D60E, I62V, L63P, K70R, T74AB
 C07-51110468C07-51110468AB864875None   I13V, R41K, D60E, I62V, L63P, K70R, T74AB
 C08-2069163C08-2069163AB868310None   P39S, I62V, L63P, A71V, T74A, V77I, I93LB
 C07-51110580C07-51110580AB864987None   L10I, E35D, R41K, I62V, L63P, T74A, I93LB
 C07-51110616C07-51110616AB865023None  Q58EI15V, E35D, N37D, I62V, L63P, A71V, T74A, I93LB
 C08-2069071C08-2069071AB868223None   K14R, I15V, R41K, R57K, L63T, A71T, I72T, T74A, I93LB
 C08-51110796C08-51110796AB865202None   T12A, M36I, I62V, L63P, A71V, T74A, V77I, I93LB
 C08-51110800C08-51110800AB865206None   T12P, K14R, I15V, E35D, M36I, N37D, I62V, L63T, A71V, T74A, I93LB
Ragonnet-Cronin (2010)PHAC_006PHAC_006HM468504None   L63T, I72T, T74A, V77I, R87RK, I93LB
 PHAC_726PHAC_726HM469224None   L33V, N37C, R41K, I62V, L63S, I64V, T74AB
Chibo (2011)S31S31JF895218None   E35D, N37E, K43R, I62V, L63Q, H69F, A71V, I72T, T74A, V77I, R87RK, I93LB
 S113S113JF895300None   I13V, E35D, N37E, I62V, L63P, T74AB
de Medeiros (2011)Pat097RS012JF487926None   N37S, R41K, H69K, T74A, V77I, R87K, L89M, I93LB
El Annaz (2011)1186311863HQ393310None   I13V, I15V, L63P, I72M, T74AB
Santos (2011)J184J184_PR_RT_CN_RHJN010585None   L10V, I15V, G16E, L19I, E35ED, M36I, N37E, K45R, R57K, I62V, L63Q, T74AB
Avila-Rios (2012)M000ME4RU0M000ME4RU0KC169218None   Q2X, I13V, L33V, R41K, I62V, L63H, I64V, K70R, T74AB
 O000M97MKMO000M97MKMKC169420None   T12A, I13V, L33V, P39PS, R41K, I62V, I64V, T74A, V82VIB
 O000MD5FTYO000MD5FTYKC169432None   L10LHP, T12TP, K14R, L33V, R41K, I62V, I64V, T74AB
 O000ME9HK0O000ME9HK0KC169434None   T12A, I13V, L33V, P39PS, R41K, I62V, L63LFV, I64V, T74AB
 VJ00MF5IUMVJ00MF5IUMKC169741None   I15V, R41K, L63P, T74AB
 D200FF6CUVD200FF6CUVKC168388None  L33IN37S, R41K, I62V, L63H, A71V, T74A, I93LB
 E000MD2JT0E000MD2JT0KC168607None   I15V, M36I, I62V, L63C, T74AB
Delwart (2012)479-2871-0479-2871-0JN215044None   G16E, N37D, I62V, L63S, T74A, V77IB
 479-7626-4479-7626-4JN215198None   E35D, N37D, I62V, L63P, T74AB
Mollan (2012)MK236MK236w0 None  L10LFI15V, I62V, T74AB
  MK236w24 None   I15V, I62V, T74AB
Ragonnet-Cronin (2012)B07_391B07_391JX014947None   I13V, Q61E, I62V, T74AB
Frentz (2013)EHR-51743EHR-51743JX300400None   I15V, Q18I, R41K, W42W*, I62V, T74A, V82I, I93LB
Pircher (2013)B1117B1117JX110304None   I64V, C67S, T74AB
Chikata (2014)KI-817KI-817AB874142None   R41K, I62V, L63P, T74AB
 KI-665KI-665AB874020None   T12P, K14R, I15V, E35D, M36I, N37D, I62V, L63T, A71V, T74A, I93LB
 KI-541KI-541AB873979None   Q7E, I62V, L63P, T74A, V77IB
 KI-693KI-693AB874043None   I15V, E35D, I62V, L63P, T74AB
 KI-951KI-951AB874237None   L10I, I15V, N37D, W42Y, I62V, L63P, A71T, T74A, V77I, I93LB
 KI-773KI-773AB874099None   I62V, L63P, A71T, T74A, V77IB
 KI-585KI-585AB873925None  Q58EI15V, E35D, N37D, I62V, L63P, A71V, T74A, I93LB
 KI-758KI-758AB874085None   L10I, N37D, W42Y, I62V, L63A, A71T, T74A, V77I, I93L, L97FB
 KI-757KI-757AB874084None   R41K, I62V, L63P, K70R, T74AB
Meixenberger (2014)09-0288209-02882KJ771084None   I13V, E35D, N37E, R57K, I62V, L63P, I72IV, T74AB
 12-0208312-02083KJ771762None   I13IV, N37NS, R41K, L63P, A71AV, T74A, V77IB
 11-0327911-03279KJ771589None   T12P, K14R, L33V, N37T, R41K, I62V, L63P, T74A, I93LB
 11-0069711-00697KJ771492None   I13IV, M36MIL, N37NS, R41K, L63P, A71AV, T74A, V77I, I93IVB
 10-0264610-02646KJ771402None   T12P, K14R, L33V, N37T, R41K, I62V, L63P, T74A, I93LB
 08-0084108-00841KJ770707None   I13V, N37NS, R41K, L63P, T74A, V77I, I93LB
 08-0157708-01577KJ770754None   I13V, E35D, N37E, R57K, L63P, T74AB