<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation T74A
Rx >= 1 PI
IncludeMixtures No
References 30
Patients 85
Isolates 97
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Molla (1996)RTV-224RTV224W32 RTV32I54L, V82SL33FI13V, I15V, I64V, T74AB
Schapiro (1996)EV10EV10_W24AF013844SQV24L90M T31X, R41K, K55R, L63Q, I64V, T74AB
 CA378CA691AF013892SQV, IDV313G48V L10I, L38F, R41K, L63P, T74AB
Patick (1998)503-42503-42W12 NFV12D30N L10I, I13V, I15V, I62V, L63I, I64P, A71T, T74A, I93LB
Shafer (1998)HMDR-33-896AF047316SQV, IDV, RTV54G48V, I54IT, V82A L10I, R41K, Q61H, I62V, L63Q, A71V, T74A, V77I, I93LB
  3-1196AF047313SQV, IDV, RTV67G48V, I54T, V82A L10I, R41K, Q61H, L63Q, A71V, T74A, V77I, I93LB
  3-197CAF047320SQV, IDV, RTV76G48V, I54T, V82A L10I, G16A, R41K, Q61H, I62V, L63Q, A71V, T74A, V77I, I93LB
Zolopa (1999)CA1159CA2635AF085113IDV, SQV, RTV51M46I, V82A, I84V L10Y, I15V, D60E, L63P, K70T, T74A, L89MB
Rousseau (2000)MNR17MNR714malAJ405961IDV, SQV, RTV, NFV102G48V, I54V, V82A L10I, R41K, L63T, H69Y, A71V, I72T, T74A, V77I, I93LB
Sevin (2000)SA-130333aSA-130333aAF226123SQV179G48V, V82A L10I, I13V, K14KR, N37D, Q61E, I64V, T74A, V77IB
Gonzales (2001)CA5235CA12909AY031792IDV, NFV135M46I, L90M I13V, R57K, I62V, L63P, A71AV, T74A, V77I, I93LB
 CA5277CA12985AY031834IDV, NFV193M46I, I54V, V82AL24I, K43TL10I, R41K, K55R, I62V, L63P, A71V, I72M, T74A, V77I, I93LB
 CA5386CA13275AY031941IDV174  I15V, R41K, I62V, I64V, T74A, V77I, I93LB
 CA5719CA14247AY032111NFV119M46I, L90LM T12S, L19I, K20I, D60DE, I62V, L63X, I64V, H69Q, T74A, V77I, I93ILB
 CA5949CA14859AY032198SQV, RTV, APV57I84V, L90M L10I, I62V, L63A, A71V, I72V, T74A, V77I, I93LB
 CA6444CA16220AY032397IDV, SQV222L90MK43KT, G73GCL10I, I13V, I62V, L63P, I64V, T74AB
 CA6595CA16537AY032501IDV, NFV215M46L, I54V, V82AL24IL10I, K14KR, Q18QH, N37D, I62V, L63P, A71V, T74AB
Kempf (2001)DK-3823DK-3823 IDV147M46L, I54V, V82AF53LL10I, T12K, I15V, I62V, L63P, A71V, T74AB
 DK-5615DK-5615 SQV, IDV166M46L, V82AL24IL10I, I15V, L19I, K55KR, I62V, L63PA, T74A, L89LMB
Kantor (2002)HMDR-3HMDR3-395AY047378SQV25G48V R41K, Q61H, I62V, L63H, A71V, T74A, V77I, I93LB
Margot (2002)MM-2042365082042365081 PINAV32VI, M46MI, V82VAL10LHFY, K43KTT12TA, R41K, I62IV, L63P, T74A, V77VI, I93LB
Romano (2002)MZ-pt26pt26-t1AF493400RTV, SQV, NFV, IDV, LPV G48V, I54A, V82AL33FL10I, K14I, I15V, G16E, L19Q, K20M, E35D, M36I, N37D, I62V, L63C, I64V, T74A, I85VB
Venturi (2002)GV-7GV-7.1AF517259SQV24  K14KR, L19V, E21EV, L38LF, I62V, L63T, T74A, V77IB
 GV-24GV-24.1AF517276SQV130  I13V, L63P, H69Q, T74A, V77IB
Monno (2003)ML_Pat43ML_Pat43 PINAD30NN88DK20I, E35D, M36I, I62V, L63P, A71V, T74AB
Saah (2003)AS-41AS-41 NFV68L90M I15V, K20T, M36I, D60E, I62V, T74A, L89IB
Wu (2003)CA5235CA16983AF544583IDV, NFV170M46I, L90M I13V, K43KN, R57K, I62V, L63P, A71V, T74A, V77I, I93LB
 CA6800CA21370AF544598SQV, RTV, APV, IDV, LPV221M46L, I84VL33F, N83DT4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89IB
Gomez-Carrillo (2004)9649096490AY365530PINAM46L, I54V, V82ML24I, L33FL10V, T12S, K14R, T26TP, N37S, R41K, I62V, L63P, I64V, T74AB
 9837198371AY365576PINA  L10V, I15V, L19T, L63V, T74A, V77IB
 118156118156AY365945PINA  L10V, I13V, I15V, L19T, L63V, T74A, V77IB
Montes (2004)MB_patRON00_RON713AJ577984NFV125I54V K20T, E35D, M36I, R41K, I62V, I64V, T74AB
Garcia-Bujalance (2005)GBS_35GBS_35AY872316SQV, NFV D30N L10LI, M36MI, I62V, L63P, I64V, T74A, V77VIB
Mo (2005)91139113_d1 PINAM46L, I54V, V82AL24IL10LI, R41K, I62V, L63P, A71V, T74A, V77I, I93LB
  9113_d339 PI, LPVNAM46L, I54V, V82AL10FVI, L24IR41K, I62V, L63P, A71V, T74A, V77VI, I93LB
Rhee (2005)CA1833CA33923AY796829IDV, NFV, SQV, RTV, APV330M46L, G48M, I54M, V82A, I84VL33FL10I, T12P, L19V, L23LV, L63T, A71V, I72T, T74A, I93LB
 CA4067CA41314AY797006NFV, UnknownNA  N37D, K43R, I62V, L63A, A71T, T74A, V77I, I93LB
 CA4565CA11216AY797125SQV, NFV132D30NN88NDI13V, I62V, L63P, I64V, T74AB
 SWC-40034003-1993 SQV, NFV104  I15V, L19I, D60X, I64V, I72M, T74AB
  4003-2848 SQV, NFV151D30N I13IV, I15V, L19I, K45KI, I64V, A71AV, I72M, T74AB
 CA5719CA42643AY797354NFV332M46I, L90M T12S, L19IT, K20I, D60E, I62V, L63P, I64V, H69Q, T74A, V77IB
 CA6452CA41242AY797408IDV, NFV, LPV179  I62V, L63P, K70R, T74A, V77IB
 CA6595CA23578AY797433IDV, NFV, RTV, APV289M46L, I54L, V82AL24I, L33FL10I, K14KR, I15IV, Q18QH, N37D, I62V, L63P, A71V, T74A, T91TAB
  CA33875AY797434IDV, NFV, RTV, APV328M46ML, I54IL, V82VAL24LI, L33LFL10LI, I15IV, Q18QH, N37ND, I62V, L63LP, A71AV, T74A, I93ILB
 CA6800CA21302AY797446SQV, RTV, APV, IDV, LPV217M46L, I84VL33F, N83DT4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89IB
 CA7988CA20471AY797629IDV, NFV241M46I, I54V, V82AL24IL10I, T12P, K14R, L63P, A71V, T74A, I93LB
 SWC-79207920-1697 IDV, NFV74  I64V, T74A, Q92HB
 CA14571CA33944AY798121NFV211  I13V, L63P, T74AB
Rodrigues (2005)BR0336801AY643195NFV, APV, LPV135G48V, I54V, V82A, I84VK43TL10I, I13V, L19LR, K20M, M36I, I62V, L63P, I64V, T74A, T91SB
Baxter (2006)12-12031203-30325DQ876063PINAM46L, G48V, I54V, V82AL33FL10V, I13V, N37HY, R41I, I62V, L63T, T74A, I85V, L89M, T91AB
 12-31253125-30501DQ876096PINAM46L, G48V, V82A L10V, T12I, I15V, G16A, N37D, R41K, K43KR, L63T, I72T, T74A, V77IB
 12-10611061-30325DQ876376PINAV32I, M46L, I47V, I54M, I84V, L90ML33FI13V, E34EQ, R41K, L63T, I64L, I66L, A71V, I72T, T74A, V77I, I93LB
 12-13811381-30423DQ876552PINAG48V, I54T, V82A L10I, T12E, I13V, K14R, G16A, N37D, Q61D, L63P, I64V, T74A, V77IB
 12-21212121-30715DQ876784PINAV32I, M46I, V82AL24I, K43TL10I, L33M, L63P, K70T, A71V, I72T, T74A, I93LB
 12-16401640-30320DQ876971PINAM46L, G48M, I54S, V82AL24I, L33F, K43TL10I, I13V, L19LI, M36L, F53Y, K55KR, I62V, L63V, I64V, T74AB
 12-17371737-30519DQ877140PINAM46L, I54V, V82AL24IL10I, I15V, N37D, I62V, I64V, A71V, T74A, I93LB
 48-10331033-30922DQ877273PINAM46L, I54V, V82A, I84VL24I, K43TL10I, I15V, K20R, E35D, M36I, N37D, I62V, L63P, A71AV, I72V, T74AB
 48-20132013-30324DQ877845PINAM46L, I54V, V82AL24I, Q58QEL10V, I15V, K20R, E35D, M36I, I62V, L63T, I72T, T74A, L89MB
 48-30183018-30725DQ877928PINAG48V, I50V, I54A, V82AK43TL10I, I13V, G16E, K20I, E35D, M36I, N37E, D60N, I62V, L63T, I72T, T74A, L89MB
 48-31333133-30428DQ878044PINAM46I, V82A, I84VL10F, L24I, Q58ET12N, I15V, L19P, K20M, L33L_L, E35ED, M36I, I62V, L63E, I64V, T74A, T91AB
 48-31753175-30422DQ878084PINAM46L, I54V, V82F, L90MV11I, L23I, L33F, F53LL10I, I13V, K43S, I62V, L63P, A71V, I72V, T74A, V77I, I93LB
 48-41944194-30502DQ878427PINAM46L, G48V, I54V, V82A, I84VL33FL10I, I64V, T74A, T91SB
 48-42834283-30919DQ878506PINAM46L, G48V, I54V, V82A, I84V L10I, I13V, Q18H, R41K, L63P, I64V, T74A, V77IB
 48-43024302-30806DQ878520PINAG48M, I54V, L76V, V82A, I84VL33F, F53LL10I, I13V, G16E, K20M, M36V, I62V, L63T, H69R, A71V, T74A, I93LB
 48-50125012-30509DQ878547PINAI54V, V82A, L90ML33F, K43T, G48W, F53LL10I, T12N, I13V, M36L, I62V, L63T, T74A, L89IB
 48-50165016-30516DQ878551PINAM46L, I54V, V82A, I84VL24I, L33F, K43TL10V, T12P, I15V, G16E, K20M, N37H, I64V, A71T, I72IR, T74A, T91AB
 48-60286028-30409DQ878627PINAI54V, V82F, L90MV11VI, L33LF, F53LL10V, I13IV, R41K, K45V, I62V, L63P, H69K, A71V, I72V, T74A, V77IB
 48-60696069-30925DQ878667PINAM46L, V82AL24IL10I, I13IV, N37D, K55KR, D60E, Q61QE, I62V, L63T, I64MV, C67E, A71V, I72T, T74A, V77I, I93LB
 48-60716071-30604DQ878669PINAM46I, L76V, V82F, L90ML23I, L33FL10I, T12K, I13V, K14KR, I62V, L63P, T74A, V77I, L89MB
 48-61896189-30723DQ878761PINAM46L, G48V, I54V, V82A L10I, N37D, I62IV, I64V, T74AB
 48-62496249-30929DQ878808PINAV32I, M46I, I47V, I54M, V82AL10FV, L33LF, K43TI15V, G16E, K20M, E34EQ, M36V, I62IMV, L63T, I72T, T74A, L89MB
 48-63046304-30910DQ878843PINAM46I, I47A, I84V L10V, I13V, I15V, G16GE, K20I, R41K, H69K, T74A, V77I, L89MB
 48-70887088-30627DQ878942PINAM46L, G48V, I54S, V82AL33F, K43TL10V, I13V, N37S, I62V, L63Q, I64V, I72V, T74A, V77IB
 48-92059205-30917DQ877486PINAM46I, I54V, L76V, V82A L10I, I13V, G16E, L19I, L63T, H69K, T74A, L89MB
 48-91599159-30924DQ877674PINAM46L, I54V, I84V, L90ML33I, L89VL10I, I15V, L19P, K20I, M36I, I62V, L63P, H69HY, A71V, T74A, I85V, I93LB
 48-93729372-30929DQ877681PINAM46L, G48V, I54V, V82T, I84V L10I, I13V, K14KN, G16E, K20R, M36I, L63T, H69Q, T74A, L89IB
 48-91039103-30908DQ877692PINAG48V, I54S, V82AL33FL10I, I13V, E35D, M36MIL, N37D, I62V, I64V, T74A, I93LB
 48-72317231-30930DQ879044PINAI54AV, V82AL24I, L33F, F53LL10I, I13V, G16E, E34EQ, M36L, N37NS, K55KR, I62V, L63C, A71AV, I72V, T74A, L89IB
 48-80498049-30819DQ879076PINAM46I, G48V, I50V, I54S, V82AL33FL10I, I13V, E34Q, R41K, I62V, L63P, A71V, I72V, T74A, V77I, I93LB
von Wyl (2007)1385233964EF449909PINA  T12S, I15V, R41K, L63P, T74AB
Riddler (2008)RG32935RG32935w99 LPV99  I13V, N37D, I62V, L63P, T74AB
Rosen-Zvi (2008)2201p22-1 SQV, IDV130L90M L10I, K20I, M36I, R41K, K43R, I62V, L63P, A71V, I72T, T74A, I93LB
Rhee (2009)CA1833CA50894GQ208286IDV, NFV, SQV, RTV, APV440M46L, G48M, I54M, V82A, I84VV11VI, L33FL10I, T12P, I13V, K14R, L19V, L63T, A71V, I72T, T74A, P79PS, I93LB
 CA5235CA57707FJ983181IDV, NFV, LPV174M46I, L90M I13V, R57K, I62V, L63P, A71V, T74A, V77I, I93LB
 CA6356CA48093FJ983196IDV, SQV, NFV364M46I I13V, E35D, I62V, L63P, A71V, T74A, V77I, I93LB
 CA14311CA64023FJ983359APV, RTV, ATV, LPV369V32I, M46IV, I47V, I54M, I84V, L90ML10F, V11I, G73T, L89VI13V, L19Q, K20M, L33V, E35A, M36I, R57K, I62V, L63P, I64V, T74AB
Dau (2010)06749A06749AGU581776PINAM46I, G48V, I54T, V82SL24I, L33F, Q58EL10I, I13V, Q61N, L63T, I64V, I72V, T74A, V77IB
 07314A07314AGU581836PINAM46I, I54V, L76V, V82A, I84V L10I, I15V, K20R, M36I, N37D, K43S, I62V, L63C, A71V, I72T, T74A, I93LB
Rhee (2010)CA25597CA87355 SQV, RTV, APV, ATV474G48V, I54V, V82A, I84V L10IV, K14R, I15V, M36I, D60E, I62V, I64V, T74AB
Jones (2012)130777130777JN669495PINAM46LL10FI13V, I15V, G16Q, K20T, P39S, L63A, I64V, I72V, T74A, V77IB
 142526142526JN669617PINAM46ML I13V, I15V, N37T, I62V, L63P, T74AB
 148146148146JN669707PINAM46I, V82TK43TT12KN, L19I, K20I, E35D, M36I, R41K, K55R, I62IV, L63T, I64IV, E65D, A71AV, I72T, T74A, I93ILB
 165823165823JN670116PINAM46L, V82TL10FT12K, I15V, G16E, L19I, K55R, L63C, I64V, T74A, V77I, I85VB
 173237173237JN670318PINAV32I, M46I, G48A, I54V, V82AK43T, F53LL10V, K14R, N37S, L63T, A71V, I72T, T74A, V77I, I93LB
 185252185252JN670699PINAI54V, V82CL33FT12K, I13V, K14N, G16A, Q18H, L19I, K20KR, M36I, I62IV, L63C, I72IV, T74A, L89MB
 198624198624JN671126PINAV32VI, M46L, I47IV, I54IATV, V82AK43TL10IV, I13V, I15V, K20I, M36I, N37ND, I62V, L63P, I64V, A71AV, T74AB
 206357206357JN671399PINAM46L, I54V, V82AL24I, K43T, F53LL10I, I15V, K20R, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, T74AB