Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	T74A
Rx	>= 1 PI
IncludeMixtures	No

References	30
Patients	85
Isolates	97

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Molla (1996)	RTV-224	RTV224W32		RTV	32	I54L, V82S	L33F	I13V, I15V, I64V, T74A	B
Schapiro (1996)	EV10	EV10_W24	AF013844	SQV	24	L90M		T31X, R41K, K55R, L63Q, I64V, T74A	B
	CA378	CA691	AF013892	SQV, Unknown, IDV	>139	G48V		L10I, L38F, R41K, L63P, T74A	B
Patick (1998)	503-42	503-42W12		NFV	12	D30N		L10I, I13V, I15V, I62V, L63I, I64P, A71T, T74A, I93L	B
Shafer (1998)	HMDR-3	3-896	AF047316	SQV, IDV, RTV	54	G48V, I54IT, V82A		L10I, R41K, Q61H, I62V, L63Q, A71V, T74A, V77I, I93L	B
		3-1196	AF047313	SQV, IDV, RTV	67	G48V, I54T, V82A		L10I, R41K, Q61H, L63Q, A71V, T74A, V77I, I93L	B
		3-197C	AF047320	SQV, IDV, RTV	76	G48V, I54T, V82A		L10I, G16A, R41K, Q61H, I62V, L63Q, A71V, T74A, V77I, I93L	B
Zolopa (1999)	CA1159	CA2635	AF085113	IDV, SQV, RTV	51	M46I, V82A, I84V		L10Y, I15V, D60E, L63P, K70T, T74A, L89M	B
Rousseau (2000)	MNR17	MNR714mal	AJ405961	IDV, SQV, RTV, NFV	102	G48V, I54V, V82A		L10I, R41K, L63T, H69Y, A71V, I72T, T74A, V77I, I93L	B
Sevin (2000)	SA-130333a	SA-130333a	AF226123	SQV	179	G48V, V82A		L10I, I13V, K14KR, N37D, Q61E, I64V, T74A, V77I	B
Gonzales (2001)	CA5235	CA12909	AY031792	IDV, NFV	135	M46I, L90M		I13V, R57K, I62V, L63P, A71AV, T74A, V77I, I93L	B
	CA5277	CA12985	AY031834	IDV, NFV	193	M46I, I54V, V82A	L24I, K43T	L10I, R41K, K55R, I62V, L63P, A71V, I72M, T74A, V77I, I93L	B
	CA5386	CA13275	AY031941	IDV	174			I15V, R41K, I62V, I64V, T74A, V77I, I93L	B
	CA5719	CA14247	AY032111	NFV	119	M46I, L90LM		T12S, L19I, K20I, D60DE, I62V, L63X, I64V, H69Q, T74A, V77I, I93IL	B
	CA5949	CA14859	AY032198	SQV, RTV, APV	57	I84V, L90M		L10I, I62V, L63A, A71V, I72V, T74A, V77I, I93L	B
	CA6444	CA16220	AY032397	IDV, SQV	222	L90M	K43KT, G73GC	L10I, I13V, I62V, L63P, I64V, T74A	B
	CA6595	CA16537	AY032501	IDV, NFV	215	M46L, I54V, V82A	L24I	L10I, K14KR, Q18QH, N37D, I62V, L63P, A71V, T74A	B
Kempf (2001)	DK-3823	DK-3823		IDV	147	M46L, I54V, V82A	F53L	L10I, T12K, I15V, I62V, L63P, A71V, T74A	B
	DK-5615	DK-5615		SQV, IDV	166	M46L, V82A	L24I	L10I, I15V, L19I, K55KR, I62V, L63PA, T74A, L89LM	B
Kantor (2002)	HMDR-3	HMDR3-395	AY047378	SQV	25	G48V		R41K, Q61H, I62V, L63H, A71V, T74A, V77I, I93L	B
Margot (2002)	MM-204236508	2042365081		PI	NA	V32VI, M46MI, V82VA	L10LHFY, K43KT	T12TA, R41K, I62IV, L63P, T74A, V77VI, I93L	B
Romano (2002)	MZ-pt26	pt26-t1	AF493400	RTV, SQV, NFV, IDV, LPV		G48V, I54A, V82A	L33F	L10I, K14I, I15V, G16E, L19Q, K20M, E35D, M36I, N37D, I62V, L63C, I64V, T74A, I85V	B
Venturi (2002)	GV-7	GV-7.1	AF517259	SQV	24			K14KR, L19V, E21EV, L38LF, I62V, L63T, T74A, V77I	B
	GV-24	GV-24.1	AF517276	SQV	130			I13V, L63P, H69Q, T74A, V77I	B
Monno (2003)	ML_Pat43	ML_Pat43		PI	NA	D30N	N88D	K20I, E35D, M36I, I62V, L63P, A71V, T74A	B
Saah (2003)	AS-41	AS-41		NFV	68	L90M		I15V, K20T, M36I, D60E, I62V, T74A, L89I	B
Wu (2003)	CA5235	CA16983	AF544583	IDV, NFV	170	M46I, L90M		I13V, K43KN, R57K, I62V, L63P, A71V, T74A, V77I, I93L	B
	CA6800	CA21370	AF544598	SQV, RTV, APV, IDV, LPV	221	M46L, I84V	L33F, N83D	T4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89I	B
Gomez-Carrillo (2004)	96490	96490	AY365530	PI	NA	M46L, I54V, V82M	L24I, L33F	L10V, T12S, K14R, T26TP, N37S, R41K, I62V, L63P, I64V, T74A	B
	98371	98371	AY365576	PI	NA			L10V, I15V, L19T, L63V, T74A, V77I	B
	118156	118156	AY365945	PI	NA			L10V, I13V, I15V, L19T, L63V, T74A, V77I	B
Montes (2004)	MB_patRON	00_RON713	AJ577984	NFV	125	I54V		K20T, E35D, M36I, R41K, I62V, I64V, T74A	B
Garcia-Bujalance (2005)	GBS_35	GBS_35	AY872316	SQV, NFV		D30N		L10LI, M36MI, I62V, L63P, I64V, T74A, V77VI	B
Mo (2005)	9113	9113_d1		PI	NA	M46L, I54V, V82A	L24I	L10LI, R41K, I62V, L63P, A71V, T74A, V77I, I93L	B
		9113_d339		PI, LPV	NA	M46L, I54V, V82A	L10FVI, L24I	R41K, I62V, L63P, A71V, T74A, V77VI, I93L	B
Rhee (2005)	CA1833	CA33923	AY796829	IDV, NFV, SQV, RTV, APV	330	M46L, G48M, I54M, V82A, I84V	L33F	L10I, T12P, L19V, L23LV, L63T, A71V, I72T, T74A, I93L	B
	CA4067	CA41314	AY797006	NFV, Unknown	NA			N37D, K43R, I62V, L63A, A71T, T74A, V77I, I93L	B
	CA4565	CA11216	AY797125	SQV, NFV	132	D30N	N88ND	I13V, I62V, L63P, I64V, T74A	B
	SWC-4003	4003-1993		SQV, NFV	104			I15V, L19I, D60X, I64V, I72M, T74A	B
		4003-2848		SQV, NFV	151	D30N		I13IV, I15V, L19I, K45KI, I64V, A71AV, I72M, T74A	B
	CA5719	CA42643	AY797354	NFV	332	M46I, L90M		T12S, L19IT, K20I, D60E, I62V, L63P, I64V, H69Q, T74A, V77I	B
	CA6452	CA41242	AY797408	IDV, NFV, LPV	179			I62V, L63P, K70R, T74A, V77I	B
	CA6595	CA23578	AY797433	IDV, NFV, RTV, APV	289	M46L, I54L, V82A	L24I, L33F	L10I, K14KR, I15IV, Q18QH, N37D, I62V, L63P, A71V, T74A, T91TA	B
		CA33875	AY797434	IDV, NFV, RTV, APV	328	M46ML, I54IL, V82VA	L24LI, L33LF	L10LI, I15IV, Q18QH, N37ND, I62V, L63LP, A71AV, T74A, I93IL	B
	CA6800	CA21302	AY797446	SQV, RTV, APV, IDV, LPV	217	M46L, I84V	L33F, N83D	T4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89I	B
	CA7988	CA20471	AY797629	IDV, NFV	241	M46I, I54V, V82A	L24I	L10I, T12P, K14R, L63P, A71V, T74A, I93L	B
	SWC-7920	7920-1697		IDV, NFV	74			I64V, T74A, Q92H	B
	CA14571	CA33944	AY798121	NFV	211			I13V, L63P, T74A	B
Rodrigues (2005)	BR033	6801	AY643195	NFV, APV, LPV	135	G48V, I54V, V82A, I84V	K43T	L10I, I13V, L19LR, K20M, M36I, I62V, L63P, I64V, T74A, T91S	B
Baxter (2006)	12-1203	1203-30325	DQ876063	PI	NA	M46L, G48V, I54V, V82A	L33F	L10V, I13V, N37HY, R41I, I62V, L63T, T74A, I85V, L89M, T91A	B
	12-3125	3125-30501	DQ876096	PI	NA	M46L, G48V, V82A		L10V, T12I, I15V, G16A, N37D, R41K, K43KR, L63T, I72T, T74A, V77I	B
	12-1061	1061-30325	DQ876376	PI	NA	V32I, M46L, I47V, I54M, I84V, L90M	L33F	I13V, E34EQ, R41K, L63T, I64L, I66L, A71V, I72T, T74A, V77I, I93L	B
	12-1381	1381-30423	DQ876552	PI	NA	G48V, I54T, V82A		L10I, T12E, I13V, K14R, G16A, N37D, Q61D, L63P, I64V, T74A, V77I	B
	12-2121	2121-30715	DQ876784	PI	NA	V32I, M46I, V82A	L24I, K43T	L10I, L33M, L63P, K70T, A71V, I72T, T74A, I93L	B
	12-1640	1640-30320	DQ876971	PI	NA	M46L, G48M, I54S, V82A	L24I, L33F, K43T	L10I, I13V, L19LI, M36L, F53Y, K55KR, I62V, L63V, I64V, T74A	B
	12-1737	1737-30519	DQ877140	PI	NA	M46L, I54V, V82A	L24I	L10I, I15V, N37D, I62V, I64V, A71V, T74A, I93L	B
	48-1033	1033-30922	DQ877273	PI	NA	M46L, I54V, V82A, I84V	L24I, K43T	L10I, I15V, K20R, E35D, M36I, N37D, I62V, L63P, A71AV, I72V, T74A	B
	48-2013	2013-30324	DQ877845	PI	NA	M46L, I54V, V82A	L24I, Q58QE	L10V, I15V, K20R, E35D, M36I, I62V, L63T, I72T, T74A, L89M	B
	48-3018	3018-30725	DQ877928	PI	NA	G48V, I50V, I54A, V82A	K43T	L10I, I13V, G16E, K20I, E35D, M36I, N37E, D60N, I62V, L63T, I72T, T74A, L89M	B
	48-3133	3133-30428	DQ878044	PI	NA	M46I, V82A, I84V	L10F, L24I, Q58E	T12N, I15V, L19P, K20M, L33L_L, E35ED, M36I, I62V, L63E, I64V, T74A, T91A	B
	48-3175	3175-30422	DQ878084	PI	NA	M46L, I54V, V82F, L90M	V11I, L23I, L33F, F53L	L10I, I13V, K43S, I62V, L63P, A71V, I72V, T74A, V77I, I93L	B
	48-4194	4194-30502	DQ878427	PI	NA	M46L, G48V, I54V, V82A, I84V	L33F	L10I, I64V, T74A, T91S	B
	48-4283	4283-30919	DQ878506	PI	NA	M46L, G48V, I54V, V82A, I84V		L10I, I13V, Q18H, R41K, L63P, I64V, T74A, V77I	B
	48-4302	4302-30806	DQ878520	PI	NA	G48M, I54V, L76V, V82A, I84V	L33F, F53L	L10I, I13V, G16E, K20M, M36V, I62V, L63T, H69R, A71V, T74A, I93L	B
	48-5012	5012-30509	DQ878547	PI	NA	I54V, V82A, L90M	L33F, K43T, G48W, F53L	L10I, T12N, I13V, M36L, I62V, L63T, T74A, L89I	B
	48-5016	5016-30516	DQ878551	PI	NA	M46L, I54V, V82A, I84V	L24I, L33F, K43T	L10V, T12P, I15V, G16E, K20M, N37H, I64V, A71T, I72IR, T74A, T91A	B
	48-6028	6028-30409	DQ878627	PI	NA	I54V, V82F, L90M	V11VI, L33LF, F53L	L10V, I13IV, R41K, K45V, I62V, L63P, H69K, A71V, I72V, T74A, V77I	B
	48-6069	6069-30925	DQ878667	PI	NA	M46L, V82A	L24I	L10I, I13IV, N37D, K55KR, D60E, Q61QE, I62V, L63T, I64MV, C67E, A71V, I72T, T74A, V77I, I93L	B
	48-6071	6071-30604	DQ878669	PI	NA	M46I, L76V, V82F, L90M	L23I, L33F	L10I, T12K, I13V, K14KR, I62V, L63P, T74A, V77I, L89M	B
	48-6189	6189-30723	DQ878761	PI	NA	M46L, G48V, I54V, V82A		L10I, N37D, I62IV, I64V, T74A	B
	48-6249	6249-30929	DQ878808	PI	NA	V32I, M46I, I47V, I54M, V82A	L10FV, L33LF, K43T	I15V, G16E, K20M, E34EQ, M36V, I62IMV, L63T, I72T, T74A, L89M	B
	48-6304	6304-30910	DQ878843	PI	NA	M46I, I47A, I84V		L10V, I13V, I15V, G16GE, K20I, R41K, H69K, T74A, V77I, L89M	B
	48-7088	7088-30627	DQ878942	PI	NA	M46L, G48V, I54S, V82A	L33F, K43T	L10V, I13V, N37S, I62V, L63Q, I64V, I72V, T74A, V77I	B
	48-9205	9205-30917	DQ877486	PI	NA	M46I, I54V, L76V, V82A		L10I, I13V, G16E, L19I, L63T, H69K, T74A, L89M	B
	48-9159	9159-30924	DQ877674	PI	NA	M46L, I54V, I84V, L90M	L33I, L89V	L10I, I15V, L19P, K20I, M36I, I62V, L63P, H69HY, A71V, T74A, I85V, I93L	B
	48-9372	9372-30929	DQ877681	PI	NA	M46L, G48V, I54V, V82T, I84V		L10I, I13V, K14KN, G16E, K20R, M36I, L63T, H69Q, T74A, L89I	B
	48-9103	9103-30908	DQ877692	PI	NA	G48V, I54S, V82A	L33F	L10I, I13V, E35D, M36MIL, N37D, I62V, I64V, T74A, I93L	B
	48-7231	7231-30930	DQ879044	PI	NA	I54AV, V82A	L24I, L33F, F53L	L10I, I13V, G16E, E34EQ, M36L, N37NS, K55KR, I62V, L63C, A71AV, I72V, T74A, L89I	B
	48-8049	8049-30819	DQ879076	PI	NA	M46I, G48V, I50V, I54S, V82A	L33F	L10I, I13V, E34Q, R41K, I62V, L63P, A71V, I72V, T74A, V77I, I93L	B
von Wyl (2007)	138	5233964	EF449909	PI	NA			T12S, I15V, R41K, L63P, T74A	B
Riddler (2008)	RG32935	RG32935w99		LPV	99			I13V, N37D, I62V, L63P, T74A	B
Rosen-Zvi (2008)	22	01p22-1		SQV, IDV	130	L90M		L10I, K20I, M36I, R41K, K43R, I62V, L63P, A71V, I72T, T74A, I93L	B
Rhee (2009)	CA1833	CA50894	GQ208286	IDV, NFV, SQV, RTV, APV	440	M46L, G48M, I54M, V82A, I84V	V11VI, L33F	L10I, T12P, I13V, K14R, L19V, L63T, A71V, I72T, T74A, P79PS, I93L	B
	CA5235	CA57707	FJ983181	IDV, NFV, LPV	174	M46I, L90M		I13V, R57K, I62V, L63P, A71V, T74A, V77I, I93L	B
	CA6356	CA48093	FJ983196	IDV, SQV, NFV	364	M46I		I13V, E35D, I62V, L63P, A71V, T74A, V77I, I93L	B
	CA14311	CA64023	FJ983359	APV, RTV, ATV, LPV, FPV	369	V32I, M46IV, I47V, I54M, I84V, L90M	L10F, V11I, G73T, L89V	I13V, L19Q, K20M, L33V, E35A, M36I, R57K, I62V, L63P, I64V, T74A	B
Dau (2010)	06749A	06749A	GU581776	PI	NA	M46I, G48V, I54T, V82S	L24I, L33F, Q58E	L10I, I13V, Q61N, L63T, I64V, I72V, T74A, V77I	B
	07314A	07314A	GU581836	PI	NA	M46I, I54V, L76V, V82A, I84V		L10I, I15V, K20R, M36I, N37D, K43S, I62V, L63C, A71V, I72T, T74A, I93L	B
Rhee (2010)	CA25597	CA87355		SQV, RTV, APV, ATV	474	G48V, I54V, V82A, I84V		L10IV, K14R, I15V, M36I, D60E, I62V, I64V, T74A	B
Jones (2012)	130777	130777	JN669495	PI	NA	M46L	L10F	I13V, I15V, G16Q, K20T, P39S, L63A, I64V, I72V, T74A, V77I	B
	142526	142526	JN669617	PI	NA	M46ML		I13V, I15V, N37T, I62V, L63P, T74A	B
	148146	148146	JN669707	PI	NA	M46I, V82T	K43T	T12KN, L19I, K20I, E35D, M36I, R41K, K55R, I62IV, L63T, I64IV, E65D, A71AV, I72T, T74A, I93IL	B
	165823	165823	JN670116	PI	NA	M46L, V82T	L10F	T12K, I15V, G16E, L19I, K55R, L63C, I64V, T74A, V77I, I85V	B
	173237	173237	JN670318	PI	NA	V32I, M46I, G48A, I54V, V82A	K43T, F53L	L10V, K14R, N37S, L63T, A71V, I72T, T74A, V77I, I93L	B
	185252	185252	JN670699	PI	NA	I54V, V82C	L33F	T12K, I13V, K14N, G16A, Q18H, L19I, K20KR, M36I, I62IV, L63C, I72IV, T74A, L89M	B
	198624	198624	JN671126	PI	NA	V32VI, M46L, I47IV, I54IATV, V82A	K43T	L10IV, I13V, I15V, K20I, M36I, N37ND, I62V, L63P, I64V, A71AV, T74A	B
	206357	206357	JN671399	PI	NA	M46L, I54V, V82A	L24I, K43T, F53L	L10I, I15V, K20R, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, T74A	B

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