Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	G73A
Rx	>= 1 PI
IncludeMixtures	No

References	14
Patients	53
Isolates	65

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Gonzales (2001)	CA1825	CA4912	AY030738	IDV, NFV	57	M46L, L90M	Q58E, G73A	L10I, L63P, A71T, I72T, V77I, I93L	B
	CA3923	CA9698	AY030924	Unknown, IDV, SQV, RTV, NFV	>151	M46I, I54IL, I84V, L90M	G73A	L10I, R57K, I62V, L63P, A71T, I72R, V77T, I93L	B
	CA5964	CA14877	AY032211	SQV, RTV, IDV, NFV, APV	197	M46I, L90M	K43T, G73A	L10I, Q18QH, K20I, L63P, A71T	B
	CA6583	CA16501	AY032489	SQV, IDV, RTV	156	M46MI, L90M	G73A	L10I, K20KM, R41K, L63P, A71T, I72R, V77I, I93L	B
Kempf (2001)	DK-8594	DK-8594		IDV	116	M46I, L90M	G73A	L10I, I13V, I15V, E35D, N37D, K55KR, R57K, I62IV, L63P, A71T, I72E, V77I, I93L	B
Kantor (2002)	CA1149	CA12790	AY047407	SQV, NFV, IDV	172	M46I, L90M	G73A	L63P, I64IV, T74S, V77I	B
Romano (2002)	MZ-pt14	pt14-t0	AF493349	SQV, IDV, NFV, RTV, APV		M46L, L90M	L33F, Q58E, G73A	L10I, E35D, M36I, N37E, D60E, I62V, L63P, A71T, I72E, V82I, I93L	B
	MZ-pt16	pt16-t0	AF493351	SQV, RTV, NFV		M46I, L90M	Q58E, G73A	L10I, N37D, I62V, L63P, I64L, A71T, I72IV, V77I, I93L	B
Wu (2003)	CA1825	CA17054	AF544514	IDV, NFV, APV	153	M46L, L90M	L33F, Q58E, G73A	L10I, L19X, I54X, L63P, H69HY, A71T, I72T, V77I, I93L	B
	CA4401	CA16514	AF544557	NFV, APV	123	L90M	G73A	L10I, L63P, V77I	B
Gomez-Carrillo (2004)	100143	100143	AY365607	PI	NA	M46I, L90M	G73A	L10I, Q18R, K20I, E35D, R41K, D60E, I62V, L63P, A71T, I72R, I93L	B
	111529	111529	AY365849	PI	NA	L90M	L33LF, G73A	L10I, L19I, N37S, R41RK, I62V, L63P, H69HY, A71AT, I72L, V77I	B
Kagan (2005)	175236	175236		PI	NA	V32I, I47A, L90M	L33F, G73A	I13V, R41K, K43R, K45R, L63P, A71T, V77I, I93L	B
Rhee (2005)	CA1341	CA48551	AY796641	IDV, SQV, RTV, NFV, APV, LPV	304	M46L, I54V, V82A, L90M	L33F, Q58E, G73A	L10I, V11L, G16A, L19I, R41K, K55R, D60E, I62V, L63P, I64M, A71I, I72M, V77I, I93L	B
	CA1825	CA38014	AY796825	IDV, NFV, APV, LPV	266	M46L, I54M, L90M	L33F, Q58E, G73A	L10I, L19LV, L63P, A71T, I72T, V77I, I93L	B
	CA4401	CA24103	AY797082	NFV, APV	172	I54M, L90M	L33F, G73A	L10I, I13V, K14KR, L63P, V77I	B
	CA5990	CA38036	AY797375	SQV, NFV, RTV, APV	395	M46I, I50V, L90M	L10F, G73A, L89LV	I13V, K20V, M36I, I62V, L63P, I64V, T74S	B
	CA6583	CA33639	AY797425	SQV, IDV, RTV, APV, LPV	256	M46I, I54IL, L90M	G73A	L10I, K20KM, R41KT, L63P, A71T, I72R, V77I, I93L	B
		CA33935	AY797426	SQV, IDV, RTV, APV, LPV	271	M46I, L90M	G73A	L10I, K20KM, R41K, L63P, A71T, I72R, V77I, I93L	B
		CA37722	AY797427	SQV, IDV, RTV, APV, LPV	298	V32I, M46I, I47V, I54L, L90M	L10F, L33F, G73A	R41T, L63P, A71T, I72R, V77I, I93L	B
	CA6602	CA38092	AY797436	Unknown, APV, LPV	>86	M46I, I54V, V82F, L90M	L33F, K43T, G73A	L10I, K20R, E35D, M36I, R57K, Q61E, I62V, L63P, I64V, I93L	B
		CA42705	AY797437	Unknown, APV, LPV	>141	M46I, I54V, V82F, L90M	L33F, K43T, G73A	L10I, K20R, E35D, M36I, R57K, Q61E, I62V, L63P, I64V, I72IT, I93L	B
Baxter (2006)	12-1970	1970-30604	DQ875975	PI	NA	M46I, I47V, I54M, I84V, L90M	L10F, G73A	I15V, L19V, K20I, E34Q, E35D, M36I, N37S, R57K, Q61H, L63P, I64V, I85IV, Q92K	B
	12-2137	2137-30723	DQ876000	PI	NA	V32I, M46I, I47V, I54M, L90M	L33F, G73A	L10I, I13V, N37NS, I62V, L63P, I66F, V77I	B
		2137-31022	DQ879122	PI, RTV, TPV	>13	V32I, M46I, I47V, I54M, L90M	L33F, G73A	L10I, I13V, I62V, L63P, I66F, I72IT, V77I	B
		2137-40728	DQ879121	PI, RTV, TPV	>53	V32IL, M46I, I47V, I54M, V82L, L90M	L33F, G73A	L10I, I13V, K55KR, I62IV, L63P, I66F, V77I, I85L	B
	12-2127	2127-30729	DQ876029	PI	NA	V32I, M46I, I47V, L90M	G73A, L89V	I13V, N37T, K43R, R57K, L63P, I64V	B
	12-1474	1474-30512	DQ876037	PI	NA	M46I, I54V, V82F, L90M	L33F, G73A	L10I, N37S, R41K, K55R, D60E, Q61QH, L63P, I64V, I72L, V77I, I93L	B
	12-1191	1191-30228	DQ876061	PI	NA	M46I, I54IV, I84V, L90M	L10F, G73A	K20I, E35D, R41K, K55R, R57K, I62V, L63P, H69C, A71T, I72T, Q92QK, I93L	B
	12-2267	2267-30820	DQ876363	PI	NA	V32I, M46I, I47V, I54M, L90M	F53L, G73A, L89V	L10I, I13V, L19P, K20V, A22AV, E35G, M36I, D60E, I62V, L63P, I64V, A71I, I72T, V77I, V82I, I85V	B
	12-1660	1660-30528	DQ876386	PI	NA	M46I, I47V, I54V, V82C, I84V, L90M	L10F, V11I, F53L, G73A, L89V	I13V, I15V, G16A, K20I, K55R, R57K, L63P, T74S, P79A	B
	12-1398	1398-30623	DQ876766	PI	NA	M46I, I47V, I54V, V82C, L90M	L33F, F53L, Q58E, G73A	L10I, L19I, E34T, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93L	B
		1398-31001	DQ879106	PI, RTV, TPV	>14	M46I, I47V, I54V, V82C, L90M	L33F, F53L, Q58E, G73A	L10IV, L19I, E34T, K55KR, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93L	B
		1398-40712	DQ879105	PI, RTV, TPV	>55	M46I, I47V, I54V, V82C, L90M	L33F, Q58E, G73A	L10V, I13V, I15V, L19I, E34T, L38LW, R41RK, K55R, Q61H, I62V, L63P, C67CW, A71T, I72E, V77I, I93L	B
	12-2042	2042-30604	DQ876918	PI	NA	I54L, V82A, L90M	L10F, L33F, K43T, G73A	I13V, G16GA, K20R, E35D, M36I, R57RK, I62V, L63P, A71V, I93L	B
	12-1690	1690-30501	DQ876976	PI	NA	V32I, M46I, I47V, I54M, L90M	L10F, L33F, G73A	I13V, E34Q, L63P, I66F, H69Q, V77I	B
	12-1750	1750-30418	DQ876984	PI	NA	M46L, G48V, V82A	L24I, Q58E, G73A, T74P, L89V	L10IV, L33M, N37D, K55R, I62V, L63P	B
	12-3033	3033-30304	DQ877213	PI	NA	M46I, L90M	L33F, G73A	L10V, T12V, I13V, R41K, D60E, I62M, L63P, A71T, I72L, V77I, I93L	B
	12-3022	3022-30304	DQ877234	PI	NA	M46I, I54L, L76V, I84V, L90M	V11VI, L33F, G73A, L89V	L10I, I13V, G16A, E34EQ, N37D, K55KR, L63P, I72M, V77I, I93L	B
	48-2201	2201-30331	DQ877854	PI	NA	I54L, I84V, L90M	L33F, G73A	L10I, V11L, I13V, N37H, R41K, K45R, L63P, A71V, V77I, I93L	B
	48-3024	3024-30303	DQ877934	PI	NA	M46I, I54M, I84V, L90M	G73A, L89V	L10I, I13A, Q18H, K20I, L63P, I64V, A71T, I72IL	B
		3024-40430	DQ877935	PI, RTV, TPV	>61	M46I, I47V, I54M, I84V, L90M	G73A, L89V	L10I, I13A, Q18H, K20I, E35EG, M36I, N37D, L63P, I64V, I66F, A71T, I72IL	B
	48-3107	3107-30507	DQ878013	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	F53L, G73A	L10Y, L19I, L33M, E34Q, R41K, D60E, L63P, A71V	B
	48-3176	3176-30425	DQ878085	PI	NA	I47V, G48V, I54M, L76V, V82C, L90M	F53L, G73A, L89V	L10I, V11L, I13V, G16A, K20V, E34Q, N37D, L63P, H69Y, A71V, V77I, I93L	B
	48-3277	3277-30731	DQ878184	PI	NA	M46I, I54V, I84V, L90M	L10F, Q58E, G73A	I13M, L19I, K20I, M36MI, K55R, D60E, L63P, I64V, A71T, I72L	B
	48-4099	4099-30218	DQ878329	PI	NA	M46L, I54V, V82A, I84V, L90M	L33F, Q58E, G73A	L10I, I13V, K20R, E35D, M36I, K55R, I62V, L63P, I66IF, A71V, I72L, Q92QR	B
	48-4200	4200-30515	DQ878432	PI	NA	M46L, I54L, V82A, L90M	L10F, L33F, K43T, F53L, G73A	G16A, L19I, L24F, E34Q, K55R, D60E, I62V, L63P, I64M, A71I, I72L, I93L	B
	48-5022	5022-30606	DQ878556	PI	NA	M46I, I54V, L76V, I84V, L90M	L10F, V11I, Q58E, G73A, L89V	I13V, K20I, L33V, E35K, M36I, K55R, D60E, I62V, L63P, I64V, A71V, T91S, I93L	B
	48-6100	6100-30618	DQ878695	PI	NA	V32I, M46I, I47V, V82VA, L90M	Q58E, G73A	L10I, I13V, I15V, G16A, K20I, E34EA, M36MI, D60E, L63P, I93L	B
	48-6223	6223-30730	DQ878790	PI	NA	M46I, I84V, L90M	G73A	L10I, L63P, C67CF, I72L, V77I, I93L	B
	48-6230	6230-30904	DQ878797	PI	NA	M46I, I84V, L90M	L33F, F53L, G73A	L10V, I13V, G16A, E35D, M36I, R41K, D60E, Q61E, L63P, G68E, A71V, I72L	B
	48-6258	6258-30902	DQ878815	PI	NA	M46I, I50IV, I54V, V82C, L90M	L10F, G73A	I13IV, Q18QH, L19LP, K20I, M36MI, N37D, L63P, I66IF, C67FY, H69K, A71T, I72R, I93L	B
	48-6342	6342-30918	DQ878865	PI	NA	V32I, M46I, I47V, I84V, L90M	L33F, G73A, L89V	L10I, N37D, L63P, I64L, A71T, P79S, I93L	B
	48-7129	7129-30915	DQ878970	PI	NA	V32I, M46I, I47V, V82S	L10F, K43T, G73A	I13V, K14KR, I15V, K20I, E35D, M36I, N37D, L63P, A71T, I72KR, I93L	B
	48-9377	9377-30930	DQ877686	PI	NA	M46I, V82T, L90M	G73A	L10I, K55R, I62V, L63P, A71T, I72E, V77I, I85V, I93L	B
Rosen-Zvi (2008)	65	00p65-1		RTV, SQV, NFV, IDV	206	M46I, I54GV, V82A, I84V, L90M	G73A	L10I, V11A, Q18QR, N37D, R41K, L63P, V75VA	B
Cardoso (2009)	3095	BRGO3095	FJ638442	PI	NA	I50V, I54V, V82A, L90M	K43T, F53L, G73A, L89V	L10IV, V11L, I13V, I15V, G16A, L19I, K20I, E35D, M36I, K55R, D60E, I62V, L63P, A71V	B
Dau (2010)	05603A	05603A	GU581676	PI	NA	I47V, I54M, L90M	V11I, L33F, K43T, G73A	L10I, I13V, N37D, I62V, L63P, I64V, A71T, I72T, V77I, I93L	B
	05892A	05892A	GU581691	PI	NA	M46I, I54V, L76V, V82A, L90M	L33F, G73A, L89V	L10I, I13V, N37D, R57K, L63P, V77I, I93L	B
	06261A	06261A	GU581722	PI	NA	M46I, I54V, L76V, V82A, L90M	L33F, G73A, L89V	L10I, I13V, N37D, R57K, L63P, V77I, I93L	B
	08882A	08882A	GU581953	PI	NA	G48V, I50IV, I54T, V82A	K43T, G73A, L89V	P9PR, L10I, I13V, L19P, K20M, E35G, M36I, I62V, L63P, C67CY, A71V	B
Rhee (2010)	CA7118	CA84197	GQ213098	SQV, RTV, APV, LPV, ATV, DRV	431	M46L, I54M, I84V, L90M	L10F, V11I, L33F, G73A	I13V, G16A, L19LV, E34Q, K43I, G51A, L63P, I64M, C67Y, A71V, I72M	B
Jones (2012)	135338	135338	JN669541	PI	NA	M46I, I54V, L76V, V82C, L90M	L10FI, Q58E, G73A	I13V, Q18H, K20I, M36MI, K55R, I62V, L63P, I64V, C67CF, K70R, A71V, I72L	B
	142746	142746	JN669624	PI	NA	M46I, I54V, L76V, V82C, L90M	L10F, Q58E, G73A	I13V, Q18H, K20I, M36I, K55R, I62V, L63P, I64V, K70R, A71V, I72L	B
	177303	177303	JN670433	PI	NA	M46I, I54V, L90M	G73A	L10I, K20I, E35D, N37D, D60E, I62V, L63P, I66F, A71T, I72T, I93L	B

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