<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation G73A
Rx >= 1 PI
IncludeMixtures No
References 20
Patients 72
Isolates 84
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gonzales (2001)CA1825CA4912AY030738IDV, NFV57M46L, L90MQ58E, G73AL10I, L63P, A71T, I72T, V77I, I93LB
 CA3923CA9698AY030924Unknown, IDV, SQV, RTV, NFV>151M46I, I54IL, I84V, L90MG73AL10I, R57K, I62V, L63P, A71T, I72R, V77T, I93LB
 CA5964CA14877AY032211SQV, RTV, IDV, NFV, APV197M46I, L90MK43T, G73AL10I, Q18QH, K20I, L63P, A71TB
 CA6583CA16501AY032489SQV, IDV, RTV156M46MI, L90MG73AL10I, K20KM, R41K, L63P, A71T, I72R, V77I, I93LB
Kempf (2001)DK-8594DK-8594 IDV116M46I, L90MG73AL10I, I13V, I15V, E35D, N37D, K55KR, R57K, I62IV, L63P, A71T, I72E, V77I, I93LB
Kantor (2002)CA1149CA12790AY047407SQV, NFV, IDV172M46I, L90MG73AL63P, I64IV, T74S, V77IB
Romano (2002)MZ-pt14pt14-t0AF493349SQV, IDV, NFV, RTV, APV M46L, L90ML33F, Q58E, G73AL10I, E35D, M36I, N37E, D60E, I62V, L63P, A71T, I72E, V82I, I93LB
 MZ-pt16pt16-t0AF493351SQV, RTV, NFV M46I, L90MQ58E, G73AL10I, N37D, I62V, L63P, I64L, A71T, I72IV, V77I, I93LB
Wu (2003)CA1825CA17054AF544514IDV, NFV, APV153M46L, L90ML33F, Q58E, G73AL10I, L19X, I54X, L63P, H69HY, A71T, I72T, V77I, I93LB
 CA4401CA16514AF544557NFV, APV123L90MG73AL10I, L63P, V77IB
Gomez-Carrillo (2004)100143100143AY365607PINAM46I, L90MG73AL10I, Q18R, K20I, E35D, R41K, D60E, I62V, L63P, A71T, I72R, I93LB
 111529111529AY365849PINAL90ML33LF, G73AL10I, L19I, N37S, R41RK, I62V, L63P, H69HY, A71AT, I72L, V77IB
Kagan (2005)175236175236 PINAV32I, I47A, L90ML33F, G73AI13V, R41K, K43R, K45R, L63P, A71T, V77I, I93LB
Rhee (2005)CA1341CA48551AY796641IDV, SQV, RTV, NFV, APV, LPV304M46L, I54V, V82A, L90ML33F, Q58E, G73AL10I, V11L, G16A, L19I, R41K, K55R, D60E, I62V, L63P, I64M, A71I, I72M, V77I, I93LB
 CA1825CA38014AY796825IDV, NFV, APV, LPV266M46L, I54M, L90ML33F, Q58E, G73AL10I, L19LV, L63P, A71T, I72T, V77I, I93LB
 CA4401CA24103AY797082NFV, APV172I54M, L90ML33F, G73AL10I, I13V, K14KR, L63P, V77IB
 CA5990CA38036AY797375SQV, NFV, RTV, APV395M46I, I50V, L90ML10F, G73A, L89LVI13V, K20V, M36I, I62V, L63P, I64V, T74SB
 CA6583CA33639AY797425SQV, IDV, RTV, APV, LPV256M46I, I54IL, L90MG73AL10I, K20KM, R41KT, L63P, A71T, I72R, V77I, I93LB
  CA33935AY797426SQV, IDV, RTV, APV, LPV271M46I, L90MG73AL10I, K20KM, R41K, L63P, A71T, I72R, V77I, I93LB
  CA37722AY797427SQV, IDV, RTV, APV, LPV298V32I, M46I, I47V, I54L, L90ML10F, L33F, G73AR41T, L63P, A71T, I72R, V77I, I93LB
 CA6602CA38092AY797436Unknown, APV, LPV>86M46I, I54V, V82F, L90ML33F, K43T, G73AL10I, K20R, E35D, M36I, R57K, Q61E, I62V, L63P, I64V, I93LB
  CA42705AY797437Unknown, APV, LPV>141M46I, I54V, V82F, L90ML33F, K43T, G73AL10I, K20R, E35D, M36I, R57K, Q61E, I62V, L63P, I64V, I72IT, I93LB
Baxter (2006)12-19701970-30604DQ875975PINAM46I, I47V, I54M, I84V, L90ML10F, G73AI15V, L19V, K20I, E34Q, E35D, M36I, N37S, R57K, Q61H, L63P, I64V, I85IV, Q92KB
 12-21372137-30723DQ876000PINAV32I, M46I, I47V, I54M, L90ML33F, G73AL10I, I13V, N37NS, I62V, L63P, I66F, V77IB
  2137-31022DQ879122PI, RTV, TPV>13V32I, M46I, I47V, I54M, L90ML33F, G73AL10I, I13V, I62V, L63P, I66F, I72IT, V77IB
  2137-40728DQ879121PI, RTV, TPV>53V32IL, M46I, I47V, I54M, V82L, L90ML33F, G73AL10I, I13V, K55KR, I62IV, L63P, I66F, V77I, I85LB
 12-21272127-30729DQ876029PINAV32I, M46I, I47V, L90MG73A, L89VI13V, N37T, K43R, R57K, L63P, I64VB
 12-14741474-30512DQ876037PINAM46I, I54V, V82F, L90ML33F, G73AL10I, N37S, R41K, K55R, D60E, Q61QH, L63P, I64V, I72L, V77I, I93LB
 12-11911191-30228DQ876061PINAM46I, I54IV, I84V, L90ML10F, G73AK20I, E35D, R41K, K55R, R57K, I62V, L63P, H69C, A71T, I72T, Q92QK, I93LB
 12-22672267-30820DQ876363PINAV32I, M46I, I47V, I54M, L90MF53L, G73A, L89VL10I, I13V, L19P, K20V, A22AV, E35G, M36I, D60E, I62V, L63P, I64V, A71I, I72T, V77I, V82I, I85VB
 12-16601660-30528DQ876386PINAM46I, I47V, I54V, V82C, I84V, L90ML10F, V11I, F53L, G73A, L89VI13V, I15V, G16A, K20I, K55R, R57K, L63P, T74S, P79AB
 12-13981398-30623DQ876766PINAM46I, I47V, I54V, V82C, L90ML33F, F53L, Q58E, G73AL10I, L19I, E34T, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93LB
  1398-31001DQ879106PI, RTV, TPV>14M46I, I47V, I54V, V82C, L90ML33F, F53L, Q58E, G73AL10IV, L19I, E34T, K55KR, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93LB
  1398-40712DQ879105PI, RTV, TPV>55M46I, I47V, I54V, V82C, L90ML33F, Q58E, G73AL10V, I13V, I15V, L19I, E34T, L38LW, R41RK, K55R, Q61H, I62V, L63P, C67CW, A71T, I72E, V77I, I93LB
 12-20422042-30604DQ876918PINAI54L, V82A, L90ML10F, L33F, K43T, G73AI13V, G16GA, K20R, E35D, M36I, R57RK, I62V, L63P, A71V, I93LB
 12-16901690-30501DQ876976PINAV32I, M46I, I47V, I54M, L90ML10F, L33F, G73AI13V, E34Q, L63P, I66F, H69Q, V77IB
 12-17501750-30418DQ876984PINAM46L, G48V, V82AL24I, Q58E, G73A, T74P, L89VL10IV, L33M, N37D, K55R, I62V, L63PB
 12-30333033-30304DQ877213PINAM46I, L90ML33F, G73AL10V, T12V, I13V, R41K, D60E, I62M, L63P, A71T, I72L, V77I, I93LB
 12-30223022-30304DQ877234PINAM46I, I54L, L76V, I84V, L90MV11VI, L33F, G73A, L89VL10I, I13V, G16A, E34EQ, N37D, K55KR, L63P, I72M, V77I, I93LB
 48-22012201-30331DQ877854PINAI54L, I84V, L90ML33F, G73AL10I, V11L, I13V, N37H, R41K, K45R, L63P, A71V, V77I, I93LB
 48-30243024-30303DQ877934PINAM46I, I54M, I84V, L90MG73A, L89VL10I, I13A, Q18H, K20I, L63P, I64V, A71T, I72ILB
  3024-40430DQ877935PI, RTV, TPV>61M46I, I47V, I54M, I84V, L90MG73A, L89VL10I, I13A, Q18H, K20I, E35EG, M36I, N37D, L63P, I64V, I66F, A71T, I72ILB
 48-31073107-30507DQ878013PINAV32I, M46I, I47V, I54M, I84V, L90MF53L, G73AL10Y, L19I, L33M, E34Q, R41K, D60E, L63P, A71VB
 48-31763176-30425DQ878085PINAI47V, G48V, I54M, L76V, V82C, L90MF53L, G73A, L89VL10I, V11L, I13V, G16A, K20V, E34Q, N37D, L63P, H69Y, A71V, V77I, I93LB
 48-32773277-30731DQ878184PINAM46I, I54V, I84V, L90ML10F, Q58E, G73AI13M, L19I, K20I, M36MI, K55R, D60E, L63P, I64V, A71T, I72LB
 48-40994099-30218DQ878329PINAM46L, I54V, V82A, I84V, L90ML33F, Q58E, G73AL10I, I13V, K20R, E35D, M36I, K55R, I62V, L63P, I66IF, A71V, I72L, Q92QRB
 48-42004200-30515DQ878432PINAM46L, I54L, V82A, L90ML10F, L33F, K43T, F53L, G73AG16A, L19I, L24F, E34Q, K55R, D60E, I62V, L63P, I64M, A71I, I72L, I93LB
 48-50225022-30606DQ878556PINAM46I, I54V, L76V, I84V, L90ML10F, V11I, Q58E, G73A, L89VI13V, K20I, L33V, E35K, M36I, K55R, D60E, I62V, L63P, I64V, A71V, T91S, I93LB
 48-61006100-30618DQ878695PINAV32I, M46I, I47V, V82VA, L90MQ58E, G73AL10I, I13V, I15V, G16A, K20I, E34EA, M36MI, D60E, L63P, I93LB
 48-62236223-30730DQ878790PINAM46I, I84V, L90MG73AL10I, L63P, C67CF, I72L, V77I, I93LB
 48-62306230-30904DQ878797PINAM46I, I84V, L90ML33F, F53L, G73AL10V, I13V, G16A, E35D, M36I, R41K, D60E, Q61E, L63P, G68E, A71V, I72LB
 48-62586258-30902DQ878815PINAM46I, I50IV, I54V, V82C, L90ML10F, G73AI13IV, Q18QH, L19LP, K20I, M36MI, N37D, L63P, I66IF, C67FY, H69K, A71T, I72R, I93LB
 48-63426342-30918DQ878865PINAV32I, M46I, I47V, I84V, L90ML33F, G73A, L89VL10I, N37D, L63P, I64L, A71T, P79S, I93LB
 48-71297129-30915DQ878970PINAV32I, M46I, I47V, V82SL10F, K43T, G73AI13V, K14KR, I15V, K20I, E35D, M36I, N37D, L63P, A71T, I72KR, I93LB
 48-93779377-30930DQ877686PINAM46I, V82T, L90MG73AL10I, K55R, I62V, L63P, A71T, I72E, V77I, I85V, I93LB
Rosen-Zvi (2008)6500p65-1 RTV, SQV, NFV, IDV206M46I, I54GV, V82A, I84V, L90MG73AL10I, V11A, Q18QR, N37D, R41K, L63P, V75VAB
Waleria-Aleixo (2008)08RJ06068508RJ060685FJ591799PINAM46I, I54V, V82F, I84V, L90ML33LF, Q58E, G73AL10I, G16A, F53Y, D60E, L63P, A71V, I72M, V77I, I93LB
Banke (2009)2807u2807uGQ334952PINAM46L, I54V, L90MG73AL10I, K20R, M36I, I62V, L63P, A71T, I72E, I93LB
Cardoso (2009)3095BRGO3095FJ638442PINAI50V, I54V, V82A, L90MK43T, F53L, G73A, L89VL10IV, V11L, I13V, I15V, G16A, L19I, K20I, E35D, M36I, K55R, D60E, I62V, L63P, A71VB
Dau (2010)05603A05603AGU581676PINAI47V, I54M, L90MV11I, L33F, K43T, G73AL10I, I13V, N37D, I62V, L63P, I64V, A71T, I72T, V77I, I93LB
 05892A05892AGU581691PINAM46I, I54V, L76V, V82A, L90ML33F, G73A, L89VL10I, I13V, N37D, R57K, L63P, V77I, I93LB
 06261A06261AGU581722PINAM46I, I54V, L76V, V82A, L90ML33F, G73A, L89VL10I, I13V, N37D, R57K, L63P, V77I, I93LB
 08882A08882AGU581953PINAG48V, I50IV, I54T, V82AK43T, G73A, L89VP9PR, L10I, I13V, L19P, K20M, E35G, M36I, I62V, L63P, C67CY, A71VB
Rhee (2010)CA7118CA84197GQ213098SQV, RTV, APV, LPV, ATV, DRV431M46L, I54M, I84V, L90ML10F, V11I, L33F, G73AI13V, G16A, L19LV, E34Q, K43I, G51A, L63P, I64M, C67Y, A71V, I72MB
Jones (2012)135338135338JN669541PINAM46I, I54V, L76V, V82C, L90ML10FI, Q58E, G73AI13V, Q18H, K20I, M36MI, K55R, I62V, L63P, I64V, C67CF, K70R, A71V, I72LB
 142746142746JN669624PINAM46I, I54V, L76V, V82C, L90ML10F, Q58E, G73AI13V, Q18H, K20I, M36I, K55R, I62V, L63P, I64V, K70R, A71V, I72LB
 177303177303JN670433PINAM46I, I54V, L90MG73AL10I, K20I, E35D, N37D, D60E, I62V, L63P, I66F, A71T, I72T, I93LB
Kouri (2012)CU1009-09CU1009-09JQ585270PINAM46I, I84V, L90MG73AL10I, Q18E, N37S, F53Y, I62V, L63P, H69Q, I72M, V77I, I93M, C95FB
Grossman (2014)3131KF135050SQV, LPV52M46MI, I54V, I84V, L90ML10F, L33F, G73AE34EQ, L63P, C67F, H69HQ, A71T, I72L, V77I, I93LB
Diaz (2015)RenG16799RenG16799KT747827PINAM46I, I54A, V82C, I84V, L90ML10F, Q58E, G73A, L89VV11L, I13V, I15V, G16A, L19T, K20I, M36I, L63P, A71I, I72E, I93LB
 RenG15971RenG15971KT746999PINAV32I, M46I, I47V, V82A, L90ML33F, K43T, G73AL10I, K14R, K20R, E35D, M36I, K55R, I62V, L63P, I66V, H69Q, K70E, A71T, I72L, I93L, C95FB
 RenG15795RenG15795KT746823PINAI50V, I54LL33F, G73A, L89VE35D, M36V, N37E, R57K, I62IV, L63P, I64L, K70KT, A71V, V82I, I93L, N98IB
 RenG15621RenG15621KT746649PINAD30N, I54LG73A, N88DL10I, I15V, E35D, M36V, N37T, I62V, L63P, I64V, I66V, A71T, I72IV, V75IB
 RenG15975RenG15975KT747003PINAM46I, I54V, V82T, I84VL10FI, L33F, G73AG16GA, I62V, L63P, A71T, I72E, V77I, I85V, I93LB
 RenG15113RenG15113KT746141PINAI54L, V82A, L90MV11I, L33F, F53L, G73AL10I, I15V, G16A, L19V, K20V, E35N, M36I, N37E, K55R, I62V, L63P, A71V, I72V, I85VB
 RenG13926RenG13926KT744954PINAI54V, V82A, L90ML23I, L33F, F53L, G73AL10I, I13V, K14R, I15V, K20T, E34Q, E35D, M36V, N37S, P39S, R41K, K55R, I62V, L63P, I64V, K70E, A71V, T74S, V77I, I93LB
 RenG12386RenG12386KT743414PINAM46I, I47V, I50IL, I54V, L90MF53L, G73A, T74PSL10V, T12K, I13V, I15V, Q18QH, K20KI, E35G, M36I, N37D, R41K, I62V, L63V, C67F, H69R, A71V, Q92EB
 RenG12552RenG12552KT743580PINAV32I, M46I, I54IV, V82AT, I84IV, L90LMG73AL10I, I15V, L19I, K20R, M36I, N37DE, I62V, L63P, I72IM, Q92R, I93L, C95FB
 RenG12862RenG12862KT743890PINAM46I, I54IV, L90MG73AL10I, I13IV, E35D, N37H, R57RK, I62V, L63P, C67L, H69Q, I72V, V77IB
 RenG11888RenG11888KT742916PINAV32I, M46L, I54IL, V82T, I84VL33F, G73AL10I, T12P, I13IV, N37Y, Q61HN, L63LP, I66V, K70E, A71I, C95FB
 RenG11392RenG11392KT742420PINAG48M, I50V, V82C, L90ML33F, G73AL10I, I13V, G16A, L19V, F53I, Q61QH, L63P, H69HY, K70KE, A71T, I72E, I93LB
Lopez (2016)2003-1692003-169KT374801PINAG48V, L90MG73AL19I, D60E, L63PB
 2001-0692001-069KT374440PINAM46I, I84V, L90MQ58E, G73AF53Y, L63P, I64V, I66VB
 2012-0242012-024KT385936PINAM46I, I54M, L90ML33I, Q58E, G73AL19LV, K20V, K55R, D60E, Q61E, I62V, L63P, I64V, I66V, A71T, I72V, V77IB