<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation A71L
Rx >= 1 PI
IncludeMixtures No
References 11
Patients 45
Isolates 52
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Shafer (1998)HMDR-44AF047321SQV, RTV69M46I, G48V, I54T, V82A, L90MI84IML10LI, N37D, L63P, A71L, V77I, I93LB
Brun (2001)SB-PtCSB-PtC-w48 NFV, LPV48M46I, I54V, L76V, L90ML33F, N88GL10I, I13V, G16A, Q18H, N37D, Q61H, L63P, A71L, I72T, V77I, I93LB
  SB-PtC-w71 NFV, LPV71M46I, I54V, L76V, V82A, L90MN88GL10I, I13V, G16A, Q18H, N37D, Q61H, I62V, L63P, A71L, I72T, V77I, I93LB
Gonzales (2001)CA3936CA9710AY030935IDV, NFV, SQV, RTV152G48V, V82A, I84V, L90M L10I, R57K, I62V, L63P, I64L, A71L, V77I, I93LB
 CA5023CA12562AY031598Unknown, NFV>69V32I, M46I, I54V, V82A L10I, N37S, I62V, L63P, A71L, I72TB
Kempf (2001)DK-23148362_d168 NFV, LPV157M46I, I54IV, L76V, L90ML33F, N88GL10I, I13V, Q18H, N37D, Q61H, L63P, A71L, I72T, V77I, I93ILB
  8362_d337 NFV, LPV181M46I, I54V, L76V, L90ML33F, N88GL10I, I13V, G16GA, Q18H, N37D, Q61H, L63P, A71L, I72T, V77I, I93LB
  8362_d501 NFV, LPV204M46I, I54V, L76V, V82VA, L90ML33F, N88GL10I, I13V, G16A, Q18H, N37D, Q61H, I62IV, L63P, A71L, I72T, V77I, I93LB
 DK-8805DK-8805 IDV, SQV, RTV169M46L, G48V, I54T, V82A L10I, R41K, L63P, A71L, I72IT, V77I, I93LB
  6359_d93 IDV, SQV, RTV, LPV182M46L, G48V, I54T, V82A L10I, R41K, L63P, H69HY, A71L, V77I, I93LB
Gonzales (2003)CA3936CA24815AY305994IDV, NFV, SQV, RTV, APV246M46I, I54IM, V82A, I84V, L90M L10I, R57K, I62V, L63P, I64L, A71L, V77I, I85IV, I93LB
Baxter (2006)12-20772077-30609DQ876018PINAV32I, M46I, I47V, I54M, V82T, L90MV11IL10R, I13V, K20I, L33V, K55R, I62V, L63P, A71L, I72L, Q92RB
 12-12181218-30707DQ876064PINAV32I, M46I, I47V, I54M, V82A, L90ML33F, F53LL10V, I13V, L24LF, E35D, M36L, N37T, L63P, A71L, V77I, I93LB
 12-17301730-30424DQ876275PINAV32I, M46I, I47V, I54M, I84V, L90ML10F, L33F, Q58ET12A, I13IV, G16A, L19I, E34Q, I62V, L63P, A71L, V77I, L89M, I93LB
 12-19011901-30605DQ876279PINAI54A, V82A, L90ML33F, G73TL10I, G16GA, E34Q, D60E, I62V, L63P, C67F, A71L, I72E, V77I, I93LB
 12-23712371-30730DQ876343PINAG48V, I54S, V82A, L90ML33F, Q58EL5F, L10I, I13V, E34Q, N37NS, D60E, I62V, L63P, H69R, A71L, V77I, I93LB
 12-19201920-30529DQ876481PINAV32I, I47V, I54M, V82A, L90ML23I, L33F, K43T, G73S, L89VL10I, K14R, G16R, E34Q, E35D, M36L, N37D, I62V, L63P, A71L, I72L, V77I, I93LB
 12-16911691-30421DQ876524PINAG48V, I54T, V82A, L90M L10I, K20R, M36I, N37D, I62V, L63P, I64L, A71L, I93LB
 12-18911891-30619DQ876579PINAM46I, G48V, I54T, V82S L10I, I15V, K20M, E35D, M36I, R41K, I62V, L63P, A71L, I93LB
 12-19981998-40316DQ879119PI, RTV, TPV>37I54A, V82AL33FL10I, I62V, L63P, A71L, I72V, V77I, I93LB
 12-20222022-30709DQ876699PINAV32I, M46I, I47V, I54L, V82A, L90ML33F, K43T, F53LL10V, G16A, L63P, A71L, I93LB
 12-15981598-30711DQ876702PINAV32I, M46I, I54V, L90ML10F, K43T, F53LV11L, K20V, E35D, M36I, N37K, L63P, A71LB
 12-11511151-30514DQ876893PINAM46L, I54V, V82A, I84VL10F, V11VI, L24I, L33F, L89LVI13V, K55R, R57K, D60DE, L63P, A71L, I72IT, T91TCS, I93LB
 12-15401540-30708DQ877004PINAM46IL, I54M, V82A, I84V, L90MQ58QEL10I, I15V, G16GA, K55R, R57K, D60DE, L63P, A71L, I93LB
 12-15911591-30618DQ877106PINAM46I, I54T, V82A, L90MK43KT, G73GSL10I, I15V, G16A, K20L, N37D, L63P, A71L, T74S, V77I, I85V, I93LB
 12-20622062-30623DQ877142PINAM46I, I47V, I54L, L76V, I84V, L90MG73S, L89VL10I, V11L, I13V, I15V, Q18H, K20I, E34Q, E35D, M36I, N37ND, D60E, I62V, L63P, A71L, I72L, I93LB
 48-18231823-30924DQ877433PINAM46I, G48V, I50V, I54ST, V82A, L90M L10I, E34Q, R41K, I62V, L63P, A71L, I72V, V77I, I93LB
 48-22042204-30401DQ877857PINAM46I, I54V, L76V, I84V, L90ML10FK20I, E34Q, E35E_G, M36I, G51A, K55R, R57RK, I62V, L63P, I66F, C67Y, A71L, I72V, Q92KB
 48-26162616-30806DQ877906PINAG48V, I50V, I54S, V82A, L90ML33FL10IV, I13V, E34Q, I62V, L63P, I64L, I66IV, H69R, A71L, I72V, V77I, I93MB
 48-30063006-30226DQ877916PINAM46L, G48V, I54S, V82A, I84VL33FL10I, R41K, D60E, I62V, L63P, A71L, V77I, T91TAGS, I93LB
 48-30163016-30408DQ877926PINAI54V, V82A, I84V, L90MQ58EL10I, L19I, K20R, E35D, M36I, N37D, I62V, L63P, A71L, I85V, T91S, I93LB
 48-31473147-30409DQ878058PINAM46L, G48M, I54T, V82A, L90ML33FL10I, E34Q, R41K, K55R, R57K, I62V, L63P, A71L, I93LB
 48-32543254-30610DQ878158PINAV32I, M46I, I47A, L90ML23I, F53FLL10I, I15V, K20T, E35N, M36I, N37D, I62V, L63P, I66IV, A71L, I72V, V77I, I93LB
 48-32963296-30728DQ878201PINAM46I, I54V, V82A, L90MK43T, G73SL10V, T12K, I15V, L19P, K20M, E34EQ, M36LV, L38W, K55R, R57K, I62V, L63P, H69K, A71L, I93M, C95LB
 48-33133313-30929DQ878215PINAG48V, I54T, V82A, L90MV11I, L33F, K43TL10I, I13V, L19T, K20KR, Q61E, I62V, L63P, A71L, I72IT, V77I, I93LB
 48-40074007-30327DQ878241PINAV32I, M46I, I47V, I50V, I54V, V82A, L90MF53LL10V, I15V, K20R, E34Q, E35D, M36V, N37E, I62V, L63P, A71L, V77L, I93LB
 48-40394039-30317DQ878273PINAI50V, I54V, I84V, L90MV11I, L89VL10I, I13V, K20I, E35D, M36I, N37D, L63P, C67F, H69R, A71L, T91TS, Q92KB
 48-40744074-30219DQ878303PINAM46L, I54V, L76V, L90ML33F, F53LT4P, T12P, I13V, K14R, K20R, E35D, M36I, N37S, R41K, I62V, L63P, A71L, I72M, V82I, I93L, C95FB
 48-40914091-30331DQ878321PINAG48L, I50V, I54S, V82A L10I, K14R, E34K, I62V, L63P, H69HY, A71L, I72IV, V77I, I93LB
 48-41424142-30325DQ878374PINAV32I, M46L, I47V, I54V, V82A, L90ML33F, F53LL10V, I15IV, K20R, E35D, M36I, N37D, R41K, K55R, R57K, L63P, A71L, I93LB
 48-42594259-30530DQ878491PINAV32I, M46I, I47V, I54M, I84V, L90ML33FL10I, V11L, N37S, L63P, A71L, I72IV, V77I, I93LB
 48-60186018-30321DQ878617PINAM46I, I54V, V82A, L90ML10FI, L33F, F53LV11VL, G16A, E34Q, G51A, K55R, Q61N, L63P, A71L, I72IM, V77I, C95LB
 48-61356135-30904DQ878716PINAV32I, I47V, I54M, I84V, L90ML33F, G73T, L89VL10I, I13V, I62V, L63P, I66F, H69N, A71L, I72T, V77IB
 48-70927092-30930DQ878946PINAM46I, I47V, I54T, V82F, L90ML33LF, K43TL10I, R41K, I62V, L63P, I64IL, A71L, V77I, I85V, L89F, I93LB
 48-92709270-30918DQ877520PINAM46L, G48V, I54S, V82A, L90MK43TL10I, I13V, I15V, Q18H, K20I, M36I, N37D, I62V, L63P, A71L, I93LB
Rosen-Zvi (2008)7705p77-3 SQV, IDV, NFV, RTV, APV, LPV368M46I, I54IL, I84V, L90ML10F, L33F, G73SL5F, I13IM, G16A, L24F, E34Q, R41K, F53Y, I62V, L63P, I64IM, A71L, I72K, V77I, I93LB
  06p77-4 SQV, IDV, NFV, RTV, APV, LPV429M46I, I54L, I84V, L90ML10F, L33F, G73SL5F, I13V, G16A, L24F, E34Q, R41K, F53Y, I62IV, L63P, I64IM, A71L, I72K, I93LB
  07p77-5 SQV, IDV, NFV, RTV, APV, LPV475M46I, I54L, I84V, L90ML10F, L33F, G73SL5F, I13V, G16A, L24F, E34Q, R41K, F53Y, I62IV, L63P, I64IM, A71L, I72K, I93LB
Rhee (2009)CA23800CA84293FJ983508IDV, NFV, RTV, APV, LPV, ATV381V32I, M46I, I47V, I50L, V82T, L90M L10R, N37H, R41K, L63P, A71L, I72V, V75VI, V77I, I93LB
Dau (2010)07033A07033AGU581811PINAV32I, M46I, I47V, I50V, V82A, L90MK43TT12P, L19I, E34Q, K55R, L63P, C67D, A71L, V77I, I93LB
Rhee (2010)CA1317CA71566 IDV, SQV, RTV, LPV, Unknown>235M46I, I54V, L90ML10F, V11I, L33LI, N88GI13L, I15V, K20T, E35N, M36I, N37D, R41K, V56A, R57K, Y59YH, I62V, L63P, C67Y, A71L, I93LB
Jones (2012)192419192419JN670850PINAV32I, M46I, I54V, L90MF53LQ18K, L19*Q, K20R, E35D, M36I, N37D, L63P, A71L, V77I, I93LB