Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	B
Gene	PR
Mutation	A71L
Rx	>= 1 PI
IncludeMixtures	No

References	11
Patients	45
Isolates	52

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Shafer (1998)	HMDR-4	4	AF047321	SQV, RTV	69	M46I, G48V, I54T, V82A, L90M	I84IM	L10LI, N37D, L63P, A71L, V77I, I93L	B
Brun (2001)	SB-PtC	SB-PtC-w48		NFV, LPV	48	M46I, I54V, L76V, L90M	L33F, N88G	L10I, I13V, G16A, Q18H, N37D, Q61H, L63P, A71L, I72T, V77I, I93L	B
		SB-PtC-w71		NFV, LPV	71	M46I, I54V, L76V, V82A, L90M	N88G	L10I, I13V, G16A, Q18H, N37D, Q61H, I62V, L63P, A71L, I72T, V77I, I93L	B
Gonzales (2001)	CA3936	CA9710	AY030935	IDV, NFV, SQV, RTV	152	G48V, V82A, I84V, L90M		L10I, R57K, I62V, L63P, I64L, A71L, V77I, I93L	B
	CA5023	CA12562	AY031598	Unknown, NFV	>69	V32I, M46I, I54V, V82A		L10I, N37S, I62V, L63P, A71L, I72T	B
Kempf (2001)	DK-2314	8362_d168		NFV, LPV	157	M46I, I54IV, L76V, L90M	L33F, N88G	L10I, I13V, Q18H, N37D, Q61H, L63P, A71L, I72T, V77I, I93IL	B
		8362_d337		NFV, LPV	181	M46I, I54V, L76V, L90M	L33F, N88G	L10I, I13V, G16GA, Q18H, N37D, Q61H, L63P, A71L, I72T, V77I, I93L	B
		8362_d501		NFV, LPV	204	M46I, I54V, L76V, V82VA, L90M	L33F, N88G	L10I, I13V, G16A, Q18H, N37D, Q61H, I62IV, L63P, A71L, I72T, V77I, I93L	B
	DK-8805	DK-8805		IDV, SQV, RTV	169	M46L, G48V, I54T, V82A		L10I, R41K, L63P, A71L, I72IT, V77I, I93L	B
		6359_d93		IDV, SQV, RTV, LPV	182	M46L, G48V, I54T, V82A		L10I, R41K, L63P, H69HY, A71L, V77I, I93L	B
Gonzales (2003)	CA3936	CA24815	AY305994	IDV, NFV, SQV, RTV, APV	246	M46I, I54IM, V82A, I84V, L90M		L10I, R57K, I62V, L63P, I64L, A71L, V77I, I85IV, I93L	B
Baxter (2006)	12-2077	2077-30609	DQ876018	PI	NA	V32I, M46I, I47V, I54M, V82T, L90M	V11I	L10R, I13V, K20I, L33V, K55R, I62V, L63P, A71L, I72L, Q92R	B
	12-1218	1218-30707	DQ876064	PI	NA	V32I, M46I, I47V, I54M, V82A, L90M	L33F, F53L	L10V, I13V, L24LF, E35D, M36L, N37T, L63P, A71L, V77I, I93L	B
	12-1730	1730-30424	DQ876275	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	L10F, L33F, Q58E	T12A, I13IV, G16A, L19I, E34Q, I62V, L63P, A71L, V77I, L89M, I93L	B
	12-1901	1901-30605	DQ876279	PI	NA	I54A, V82A, L90M	L33F, G73T	L10I, G16GA, E34Q, D60E, I62V, L63P, C67F, A71L, I72E, V77I, I93L	B
	12-2371	2371-30730	DQ876343	PI	NA	G48V, I54S, V82A, L90M	L33F, Q58E	L5F, L10I, I13V, E34Q, N37NS, D60E, I62V, L63P, H69R, A71L, V77I, I93L	B
	12-1920	1920-30529	DQ876481	PI	NA	V32I, I47V, I54M, V82A, L90M	L23I, L33F, K43T, G73S, L89V	L10I, K14R, G16R, E34Q, E35D, M36L, N37D, I62V, L63P, A71L, I72L, V77I, I93L	B
	12-1691	1691-30421	DQ876524	PI	NA	G48V, I54T, V82A, L90M		L10I, K20R, M36I, N37D, I62V, L63P, I64L, A71L, I93L	B
	12-1891	1891-30619	DQ876579	PI	NA	M46I, G48V, I54T, V82S		L10I, I15V, K20M, E35D, M36I, R41K, I62V, L63P, A71L, I93L	B
	12-1998	1998-40316	DQ879119	PI, RTV, TPV	>37	I54A, V82A	L33F	L10I, I62V, L63P, A71L, I72V, V77I, I93L	B
	12-2022	2022-30709	DQ876699	PI	NA	V32I, M46I, I47V, I54L, V82A, L90M	L33F, K43T, F53L	L10V, G16A, L63P, A71L, I93L	B
	12-1598	1598-30711	DQ876702	PI	NA	V32I, M46I, I54V, L90M	L10F, K43T, F53L	V11L, K20V, E35D, M36I, N37K, L63P, A71L	B
	12-1151	1151-30514	DQ876893	PI	NA	M46L, I54V, V82A, I84V	L10F, V11VI, L24I, L33F, L89LV	I13V, K55R, R57K, D60DE, L63P, A71L, I72IT, T91TCS, I93L	B
	12-1540	1540-30708	DQ877004	PI	NA	M46IL, I54M, V82A, I84V, L90M	Q58QE	L10I, I15V, G16GA, K55R, R57K, D60DE, L63P, A71L, I93L	B
	12-1591	1591-30618	DQ877106	PI	NA	M46I, I54T, V82A, L90M	K43KT, G73GS	L10I, I15V, G16A, K20L, N37D, L63P, A71L, T74S, V77I, I85V, I93L	B
	12-2062	2062-30623	DQ877142	PI	NA	M46I, I47V, I54L, L76V, I84V, L90M	G73S, L89V	L10I, V11L, I13V, I15V, Q18H, K20I, E34Q, E35D, M36I, N37ND, D60E, I62V, L63P, A71L, I72L, I93L	B
	48-1823	1823-30924	DQ877433	PI	NA	M46I, G48V, I50V, I54ST, V82A, L90M		L10I, E34Q, R41K, I62V, L63P, A71L, I72V, V77I, I93L	B
	48-2204	2204-30401	DQ877857	PI	NA	M46I, I54V, L76V, I84V, L90M	L10F	K20I, E34Q, E35E_G, M36I, G51A, K55R, R57RK, I62V, L63P, I66F, C67Y, A71L, I72V, Q92K	B
	48-2616	2616-30806	DQ877906	PI	NA	G48V, I50V, I54S, V82A, L90M	L33F	L10IV, I13V, E34Q, I62V, L63P, I64L, I66IV, H69R, A71L, I72V, V77I, I93M	B
	48-3006	3006-30226	DQ877916	PI	NA	M46L, G48V, I54S, V82A, I84V	L33F	L10I, R41K, D60E, I62V, L63P, A71L, V77I, T91TAGS, I93L	B
	48-3016	3016-30408	DQ877926	PI	NA	I54V, V82A, I84V, L90M	Q58E	L10I, L19I, K20R, E35D, M36I, N37D, I62V, L63P, A71L, I85V, T91S, I93L	B
	48-3147	3147-30409	DQ878058	PI	NA	M46L, G48M, I54T, V82A, L90M	L33F	L10I, E34Q, R41K, K55R, R57K, I62V, L63P, A71L, I93L	B
	48-3254	3254-30610	DQ878158	PI	NA	V32I, M46I, I47A, L90M	L23I, F53FL	L10I, I15V, K20T, E35N, M36I, N37D, I62V, L63P, I66IV, A71L, I72V, V77I, I93L	B
	48-3296	3296-30728	DQ878201	PI	NA	M46I, I54V, V82A, L90M	K43T, G73S	L10V, T12K, I15V, L19P, K20M, E34EQ, M36LV, L38W, K55R, R57K, I62V, L63P, H69K, A71L, I93M, C95L	B
	48-3313	3313-30929	DQ878215	PI	NA	G48V, I54T, V82A, L90M	V11I, L33F, K43T	L10I, I13V, L19T, K20KR, Q61E, I62V, L63P, A71L, I72IT, V77I, I93L	B
	48-4007	4007-30327	DQ878241	PI	NA	V32I, M46I, I47V, I50V, I54V, V82A, L90M	F53L	L10V, I15V, K20R, E34Q, E35D, M36V, N37E, I62V, L63P, A71L, V77L, I93L	B
	48-4039	4039-30317	DQ878273	PI	NA	I50V, I54V, I84V, L90M	V11I, L89V	L10I, I13V, K20I, E35D, M36I, N37D, L63P, C67F, H69R, A71L, T91TS, Q92K	B
	48-4074	4074-30219	DQ878303	PI	NA	M46L, I54V, L76V, L90M	L33F, F53L	T4P, T12P, I13V, K14R, K20R, E35D, M36I, N37S, R41K, I62V, L63P, A71L, I72M, V82I, I93L, C95F	B
	48-4091	4091-30331	DQ878321	PI	NA	G48L, I50V, I54S, V82A		L10I, K14R, E34K, I62V, L63P, H69HY, A71L, I72IV, V77I, I93L	B
	48-4142	4142-30325	DQ878374	PI	NA	V32I, M46L, I47V, I54V, V82A, L90M	L33F, F53L	L10V, I15IV, K20R, E35D, M36I, N37D, R41K, K55R, R57K, L63P, A71L, I93L	B
	48-4259	4259-30530	DQ878491	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	L33F	L10I, V11L, N37S, L63P, A71L, I72IV, V77I, I93L	B
	48-6018	6018-30321	DQ878617	PI	NA	M46I, I54V, V82A, L90M	L10FI, L33F, F53L	V11VL, G16A, E34Q, G51A, K55R, Q61N, L63P, A71L, I72IM, V77I, C95L	B
	48-6135	6135-30904	DQ878716	PI	NA	V32I, I47V, I54M, I84V, L90M	L33F, G73T, L89V	L10I, I13V, I62V, L63P, I66F, H69N, A71L, I72T, V77I	B
	48-7092	7092-30930	DQ878946	PI	NA	M46I, I47V, I54T, V82F, L90M	L33LF, K43T	L10I, R41K, I62V, L63P, I64IL, A71L, V77I, I85V, L89F, I93L	B
	48-9270	9270-30918	DQ877520	PI	NA	M46L, G48V, I54S, V82A, L90M	K43T	L10I, I13V, I15V, Q18H, K20I, M36I, N37D, I62V, L63P, A71L, I93L	B
Rosen-Zvi (2008)	77	05p77-3		SQV, IDV, NFV, RTV, APV, LPV, FPV	368	M46I, I54IL, I84V, L90M	L10F, L33F, G73S	L5F, I13IM, G16A, L24F, E34Q, R41K, F53Y, I62V, L63P, I64IM, A71L, I72K, V77I, I93L	B
		06p77-4		SQV, IDV, NFV, RTV, APV, LPV, FPV	429	M46I, I54L, I84V, L90M	L10F, L33F, G73S	L5F, I13V, G16A, L24F, E34Q, R41K, F53Y, I62IV, L63P, I64IM, A71L, I72K, I93L	B
		07p77-5		SQV, IDV, NFV, RTV, APV, LPV, FPV	475	M46I, I54L, I84V, L90M	L10F, L33F, G73S	L5F, I13V, G16A, L24F, E34Q, R41K, F53Y, I62IV, L63P, I64IM, A71L, I72K, I93L	B
Rhee (2009)	CA23800	CA84293	FJ983508	IDV, NFV, RTV, APV, LPV, ATV	381	V32I, M46I, I47V, I50L, V82T, L90M		L10R, N37H, R41K, L63P, A71L, I72V, V75VI, V77I, I93L	B
Dau (2010)	07033A	07033A	GU581811	PI	NA	V32I, M46I, I47V, I50V, V82A, L90M	K43T	T12P, L19I, E34Q, K55R, L63P, C67D, A71L, V77I, I93L	B
Rhee (2010)	CA1317	CA71566		IDV, SQV, RTV, LPV, Unknown	>235	M46I, I54V, L90M	L10F, V11I, L33LI, N88G	I13L, I15V, K20T, E35N, M36I, N37D, R41K, V56A, R57K, Y59YH, I62V, L63P, C67Y, A71L, I93L	B
Jones (2012)	192419	192419	JN670850	PI	NA	V32I, M46I, I54V, L90M	F53L	Q18K, L19*Q, K20R, E35D, M36I, N37D, L63P, A71L, V77I, I93L	B

Protease Inhibitors

Database

Resources

Team