<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation L63V
Rx PI-naive
IncludeMixtures No
References 98
Patients 200
Isolates 205
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Schapiro (1996)EV37EV37_W0AF013885None   I62V, L63V, I93LB
Patick (1998)503-283503-283B None   L10I, I15V, L63V, I93LB
Bacheler (2000)LB4-P113P113-0 None   L10I, I15V, L63V, I93LB
Albrecht (2001)ACTG364_12021202 None   E35D, R41K, L63V, A71V, I72IM, I93LB
Gonzales (2001)CA2106CA7766AY030813None   L10I, L19I, M36I, L63V, H69HQB
 CA4794CA11840AY031453None   R41K, I62IV, L63V, A71V, I72EV, V77I, I93LB
 CA6556CA16480AY032462None   I13V, I15V, K20I, M36I, N37D, L63V, I64M, L89MB
Perno (2001)PCF_Pat77PCF1107AF376564None   I15V, M36I, L38LF, L63V, H69KB
 PCF_Pat86PCF272AF376529None   K14KR, G16GE, M36I, R41K, R57K, D60E, L63V, I64V, E65DB
Servais (2001)JS98395JS98395AJ279674None   N37A, L63VB
Dumans (2002)AD-14AD-14AF413833None   Q18L, L63V, V77IB
Gibb (2002)DMG5454_w0 None   K14KR, I15V, L19LI, L63V, H69IM, I93ILB
  54_w25 None   K14R, I15IV, Q18QH, L19LI, L63V, H69IM, I93ILB
  54_w48 None   K14R, I15V, Q18QHL, L63V, H69MB
Machado (2002)183cdpol183AF373720None   T12S, K14R, I62V, L63V, I64VB
 185cdpol185AF373722None   I15V, L63VB
Brindeiro (2003)BRP2137BRP2137AY213433None   E35D, R57K, Q61H, L63V, L89MB
Maljkovic (2003)MI_Pat6100SE19853AY165238None   L10LI, T12TI, I13IV, K14KR, L33V, L63V, I64V, I93LB
Shafer (2003)A384_09170917aEF548344None   L10I, I15V, E35D, N37D, R57K, I62V, L63V, I66IM, A71T, V82I, I93LB
 A384_08450845aEF548460None   L10I, I13V, L19T, L63V, A71T, V77IB
 A384_11411141aEF548990None   L10I, I15V, L63V, H69QB
 A384_25312531aEF549201None   T12A, M36I, N37D, L38LF, L63V, I93LB
Soares (2003)BRRJ877BRRJ877AF527358None   L10I, I15V, G16R, M36I, L63V, H69QB
Gulick (2004)RG137RG137w0 None   L10I, K14R, L33LV, E35ED, N37AT, R41K, R57RK, L63V, I64V, I93LB
  RG137w18 None   L10I, K14R, L33V, E35ED, N37A, R41K, L63V, I64V, I93LB
  RG137w27 None   L10I, K14R, L33V, N37A, R41K, L63V, I64V, I93LB
 RG385RG385w0 None   T12S, L19I, I62V, L63V, A71V, I72T, I93LB
Kuritzkes (2004)KDR_pat158A0207AY528024None   N37D, L63V, V77VIB
Grossman (2005)2488824888PR372 None   T12N, G16GR, L19I, Q61QH, L63V, K70RB
Podzamczer (2005)DP_401DP_401m5 None   I15V, L63V, V77I, N83NYB
Rhee (2005)CA16543CA39275AY798264None   L10I, L63V, I64V, C67SB
Weber (2005)WJ_pat77287728_W0AY736114None   L10I, I15V, L19I, R41K, D60E, Q61E, L63V, H69Q, V77IB
  7728_W32AY736115None   L10I, I15V, L19I, R41K, D60E, Q61E, L63V, H69Q, V77IB
Jayaraman (2006)3-00-01113-00-0111 None   I15V, E35D, N37D, L63V, I93LB
Lama (2006)Pt35933593 None   T12K, I62V, L63V, V77IB
 Pt52605260 None   L10I, T12P, L19I, L63V, C67Y, H69Q, A71V, I72T, I93LB
 Pt75377537 None   L10V, L63V, K70R, I72T, L89MB
Lindstrom (2006)SIIDC0277SIIDC0277 None   I15V, N37Q, L63VB
 SIIDC0104SIIDC0104 None   L10I, L63V, I93LB
 SIIDC0154SIIDC0154 None   L10I, L63V, I64V, I93LB
 SIIDC0197SIIDC0197 None   L10I, T12TA, I15V, G16GE, P39PT, L63V, I93LB
Petroni (2006)AP_ARRP021AP_ARRP021DQ206670None   N37H, R41K, L63VB
Brumme (2007)1426PRRT_1426EF368736None   I15V, I62V, L63V, C67S, I72V, V77IB
Dilernia (2007)F278F278EF120207None   L10I, T12A, K14R, L63V, I64V, H69Q, V77IB
Gonsalez (2007)60HIV_60GU288774None   L10I, I15V, N37E, R57RK, D60DE, L63V, C67SB
 61HIV_61GU288742None   L10I, I15V, G16A, N37E, L63V, C67SB
Rios (2007)CH46MR_CH46EF193937None   L10I, T12P, I15IV, G16E, E35D, P39S, L63V, C67CG, I93LB
Holguin (2008)SP107-329080SP107-329080EU255453None   N37NS, I62V, L63V, I72V, V77IB
Lloyd (2008)TX17103HN_TX171EU312909None   L19I, L63V, I64V, I72VB
 TX19603HN_TX196EU312926None   T12S, L19I, N37S, L63V, K70R, V77VIB
 TX20503HN_TX205EU312934None   G16GE, L63VB
 TX24903HN_TX249EU312969None   T12TP, I15V, L19IT, L63V, I72T, V77IB
Ndembi (2008)IAEAM016IAEAM016EU306754None   I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89MB
Somi (2008)KG-05-429KG-05-429JQ616977None   I13V, K14R, K20M, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93ILB
Brennan (2009)A46ARC-A46EU711461None   Q18E, L63V, I64V, K70R, V75I, V77IB
Brumme (2009)O9574O9574GQ372074None   R41K, I62V, L63V, I93LB
 P4576P4576GQ372086None   I15V, M36V, I62V, L63V, T74SB
 PRRT_4085PRRT_4085GQ303774None   K14R, N37D, L63VB
 PRRT_4142PRRT_4142GQ303831None   L10V, T12P, L19I, E35D, N37NS, R41K, L63V, A71T, I93LB
 PRRT_4178PRRT_4178GQ303867None   L10V, T12P, N37S, R41K, W42W*, G51GE, L63V, G68GE, R87RK, L89M, I93LB
Cardoso (2009)BRGO3109BRGO3109FJ594159None   G17D, R41K, I62V, L63V, H69K, A71T, I93LB
Castillo (2009)5151PROTGQ202971None   K14R, N37DE, L63V, C67S, A71V, I72T, V77I, I93LB
Cuevas (2009)X2513_1X2513_1GU326117None   L10S, T12P, L63V, I64VB
 X2689_1X2689_1GU326173None   T12P, K14R, R41K, L63V, A71V, I72M, V77I, I93LB
de Sa-Filho (2009)5536155361PgrGQ294613None   L10V, I15V, G16E, L19I, N37E, P39S, L63VB
Dumans (2009)97_0597_05FJ405103None   Q2L, L10V, I13V, K14R, L33V, N37A, P39Q, L63V, I64VB
Fujisaki (2009)608608AB442274None   L10I, T12P, I15V, M36L, N37S, R41RK, I62V, L63V, I64V, I93LB
Nadai (2009)129517129517EU839600None   L19V, N37S, R41K, R57K, L63VB
Smith (2009)PI62US2002PI62 None   L10I, K14R, N37D, R41K, L63V, V77I, I93LB
 PI242US1999PI242 None   L10I, K14R, I15V, N37D, R41K, L63V, V77I, I93LB
 CR82US2006CR82 None   L10I, T12P, I13V, I62V, L63V, A71TB
 CR173US2006CR173 None   G16E, I62V, L63V, I64IM, V77I, I93LB
Vercauteren (2009)pt18921947360640GQ399132None   G16E, M36MI, N37S, I62V, L63VB
 pt18731xa4qSFZvvGQ399151None   L10I, Q18R, N37S, R41K, I62V, L63V, A71T, I72T, V77I, I93LB
 pt15563993935960GQ399468None   N37T, L63VB
 pt13854961244561GQ399639None   L10I, T12A, I13V, M36I, I62V, L63V, I64VB
 pt10576897180640GQ399967None   L10V, E35D, R41K, L63V, A71V, I93LB
 pt9837369234238GQ400041None   L10I, K14R, L19I, N37S, R41K, I62V, L63V, I93LB
 pt9407604935324GQ400084None   I15V, L63VB
 pt9197741425074GQ400105None  T74TPE35D, M36I, N37D, D60E, I62V, L63V, I64V, I72TB
 pt452Bz6I1lHzBfGQ400572None   T12P, L19I, L63V, I93LB
Wallis (2009)GT00349623GT00349623 None   K14R, I15V, L19V, M36I, R41K, L63V, H69K, V82I, L89M, I93LB
Wang (2009)L8180L8180FJ469743None   L19I, N37S, L63V, H69Q, V77IB
Brennan (2010)Pat088ARC-A146JN697291None   N37D, R41K, D60E, L63V, E65D, V77IB
Cuevas (2010)X2689-2X2689-2GU362885None   T12P, K14R, R41K, L63V, A71V, I72M, V77I, I93LB
Hattori (2010)C07-2069089C07-2069089AB868080None   G16E, K45R, L63V, H69K, I93LB
 C07-51110588C07-51110588AB864995None   N37S, L63V, V77I, V82IB
 F08-5112188F08-5112188AB866819None   I13V, K14R, I15V, N37S, R41K, I62V, L63V, I64VB
 C07-51110543C07-51110543AB864950None   G16E, K45R, L63V, H69K, I93LB
 C08-2069152C08-2069152AB868300None   G16E, K45R, L63V, H69K, V77I, I93LB
 C07-51110586C07-51110586AB864993None   G16E, K45R, L63V, H69K, I93LB
 F06-5103205F06-5103205AB866452None   G16E, M36I, K45R, L63V, H69K, I93LB
 C07-51110517C07-51110517AB864924None   L10I, E35D, R41K, L63V, A71T, I72V, V77I, I93LB
 C08-51110775C08-51110775AB865181None   T12S, G16E, L19I, M36I, N37D, K45R, L63V, H69K, I93LB
 C08-51110748C08-51110748AB865155None   I13V, N37S, I62V, L63V, G68E, A71V, V77I, I93LB
Ragonnet-Cronin (2010)PHAC_154PHAC_154HM468652None   I15V, E35D, N37D, R57RK, L63V, A71T, V77I, I93LB
 PHAC_287PHAC_287HM468785None  V11VIT12P, I15V, M36I, N37D, R57K, L63V, C67WB
 PHAC_377PHAC_377HM468875None   L10I, T12TKPQ, I15V, R41K, L63V, V77I, I93LB
 PHAC_392PHAC_392HM468890None   L10V, I15V, R41K, L63V, V77I, I93LB
Yebra (2010)25610005SP0256100FJ481796None   T12TP, I13V, I15IV, M36I, N37E, R57RK, L63V, H69HY, V77VI, L89MB
Chibo (2011)S4S4JF895191None   L10V, I15V, L19I, N37S, R41K, Y59YF, L63V, E65D, H69YB
 S150S150JF895337None   L10V, T12A, I15V, L19I, E35D, N37E, L63V, E65D, H69YB
de Medeiros (2011)Pat006RS072JF487835None   T4H, L5F, L10I, T12K, I15V, E21G, L24F, M36I, N37K, R41N, L63V, H69K, I93LB
 Pat035RS077JF487864None   I15V, E35D, N37S, R41K, L63V, H69K, L89MB
Ferreira (2011)BRMT2244BRMT2244HQ638790None   L10V, T12Q, K14R, I15V, M36I, N37E, R41K, L63V, H69R, K70RB
Graf (2011)SC142SC142JF774061None   L19I, N37T, R41K, L63V, H69K, V77IB
Hamers (2011)CP076300708CP076300708HQ994921None   L10I, I13V, I15IV, G16E, E35D, D60E, L63V, I64V, H69Q, I72VB
Rolland (2011)1400consensus_1400JF320043None   T12P, I15V, L19I, P39S, L63V, T91V, I93LB
Santos (2011)J159J159_PR_RTJN010549None   L10I, I13V, L19I, N37S, R41K, I62V, L63VB
 J350J350_PR_RT_CNJN010733None   L10I, G16E, N37A, P39S, R41K, I62K, L63V, V77I, I93LB
Avila-Rios (2012)JC00MG0OTWJC00MG0OTWKC169106None   M36MI, N37ND, R41RK, L63V, I64V, K70RB
 M800FE4I7FM800FE4I7FKC169269None   I15IV, N37D, L63V, I93LB
 ME00M9ILO1ME00M9ILO1KC169291None   L10I, M36I, L63V, I64V, H69QB
 OE00M77IUBOE00M77IUBKC169481None   L10I, M36MI, R41K, L63V, I64V, I93LB
 PCT0X98TJ7PCT0X98TJ7KC169583None   I15V, M36MI, R41K, L63V, K70RB
 V000MU4ET9V000MU4ET9KC169692None   T12S, I15V, L19I, M36MI, N37S, R41K, L63VB
 D000MD1OJXD000MD1OJXKC168318None   T4TN, L19I, R41K, L63V, I72V, V77I, R87RKB
 D000MIBCUVD000MIBCUVKC168352None   I15V, L63V, V77I, I93LB
 E2E0MF5QU9E2E0MF5QU9KC168723None   L10I, I13V, M36MI, N37D, R57K, L63V, H69Y, A71V, I72T, I93LB
 GA00MF8IRPGA00MF8IRPKC168883None   I15V, L63V, K70R, V77IB
 J800MBEKV4J800MBEKV4KC169078None   Q18E, M36I, N37HQ, I62V, L63VB
De Gascun (2012)IRL35902IRL35902JN622487None   I15V, E35D, N37E, L38LW, D60DA, Q61QP, I62V, L63V, H69K, A71TB
 IRL41024IRL41024JN622502None   K14KR, I15IV, E35D, N37E, I62V, L63V, E65ED, H69K, A71TB
Delwart (2012)477-0278-4477-0278-4JN214906None   T12TI, I15V, G16GE, R41K, I62V, L63V, V77I, I93LB
 479-1062-6479-1062-6JN215039None   I15V, M36I, R41K, L63V, I72VB
 477-3191-5477-3191-5JN215130None   N37S, R41K, L63VB
Gaspareto (2012)LBS41LBS41PTHM752172None   T4S, T12K, I15V, M36L, R41K, Q61N, I62V, L63V, I64M, E65DB
Murillo (2012)1115711157KC412745None   I15V, L19I, N37T, R41K, L63V, E65D, V77IB
Ragonnet-Cronin (2012)C05_017C05_017JX014981None   I15V, E35D, N37D, L63V, P81T, I93LB
 C06_045C06_045JX015004None   I15V, E35D, N37D, L63V, G68E, A71V, I93LB
 E10_054E10_054JX015062None   T12I, I15V, E35ED, N37D, L63V, I93LB
 F06_021F06_021JX015071None   L10LIV, K14KR, L19LQ, R57RK, L63V, E65ED, A71ATB
Alencar (2013)SP2-0016SP2-0016JQ237971None   K14KR, E35ED, N37NK, R41K, L63V, I64V, K70RB
 PE2-0041PE2-0041JQ238055None   T12N, I15V, L19I, M36MIL, R41K, L63V, V77VIB
 PE2-0095PE2-0095JQ238211None   I15V, L19V, E35D, L63VB
Avidor (2013)787787KC184391None   E35D, M36I, R41K, R57RK, L63V, H69K, L89MB
Barrow (2013)7575 None   T12S, K14MT, L19Q, N37S, R41K, D60E, L63V, I64V, E65D, V77IB
Brooks (2013)CAN2013-063CAN13-063KF727957None   L63V, V77I, I93LB
 CAN2013-081CAN13-081KF727959None   I15V, E35D, N37D, L63V, I93LB
 CAN2013-170CAN13-170KF727960None   I15V, E35D, N37D, L63V, I93LB
Ferreira (2013)BR09SP107BR09SP107HM534012None   L10I, K14R, I15V, L19I, M36I, N37E, L63V, V77I, I93LB
 BR09SP78BR09SP78HM534061None   L10I, L63V, H69Q, I93LB
Frentz (2013)EHR-07738EHR-07738JX299667None   L63VB
 EHR-35815EHR-35815JX300140None   L63VB
 EHR-58877EHR-58877JX300524None   E35D, L63V, I64V, E65DB
 EHR-64740EHR-64740JX300629None   L10I, N37S, R41K, L63V, K70R, I93LB
 EHR-81373EHR-81373JX300928None   I15V, R57K, L63V, I72V, V77IB
Hawke (2013)2547988 H2547988HKC238089None   L10I, I15V, E35D, N37NT, I62V, L63V, I93LB
Holguin (2013)ES90ES90JX466963None   K14M, L19R, R41K, D60E, L63V, E65D, V77I, L89IB
 ES146ES146JX467010None   L10I, I13V, I15V, L63V, I64V, I72T, V77I, I93LB
Kiertiburanakul (2013)R42083R42083KC971039None   I13V, L63V, I64M, H69K, V82I, L89MB
 R51054R51054KF059635None  L33FI13V, K14R, N37S, Q61E, I62V, L63V, I64V, V77I, I93LB
Lunar (2013)pt20211214439289GQ399003None   L63VB
 pt15304093797321GQ399494None   L63VB
 6416-106416-10JX028318None   K14R, I15V, R41K, L63V, H69HN, I72V, V77IB
Manasa (2013)RES075RES075KC951685None   T12S, I15V, G16E, L19I, M36MI, N37S, L63V, H69K, I72V, L89M, I93LB
Ong (2013)09MYKL07309MYKL073KC181289None   I13V, L63V, I64M, H69K, V82I, L89MB
Theys (2013)60866086KY386679None   L10I, I13V, I15V, M36I, N37D, L63VB
Chikata (2014)KI-873KI-873AB874181None   G16E, K45R, L63V, H69K, I93LB
 KI-662KI-662AB874017None   T12S, G16E, L19I, M36I, K45KR, L63V, H69K, I93LB
Liegler (2014)90102029010202KJ586005None   K14R, N37D, K45KR, L63VB
Martin (2014)ACU111ACU111KJ870010None   I15V, E35D, N37D, L63V, I93LB
Meixenberger (2014)09-0306409-03064KJ771095None   T12P, G16E, I62V, L63V, E65D, I72V, V77VI, I93LB
 00-0016200-00162KJ769688None   L19I, R57RK, I62V, L63V, A71V, I93LB
 10-0229410-02294KJ771333None   R41K, R57K, I62V, L63V, C67CY, A71V, V77I, I93LB
 09-0290909-02909KJ771088None   L19I, K43R, L63V, V77IB
Parczewski (2014)145_GD11145_GD11KM283957None   T4S, L10I, N37T, R41K, K43KR, L63V, I64V, H69HY, K70R, I93LB
 A067_1A067_1KM284544None   L10I, N37D, R57RK, L63V, I64IL, A71T, V77I, I93LB
Ross (2014)845845KF262943None   L10I, R41K, L63V, I93LB
 858858KF262956None   K14R, I15V, E35D, N37D, L63VB
 811811KF262909None   I15V, E35D, N37D, L63V, A71AT, I93LB
 10431043KF263042None   L63V, I72V, V77I, I93LB
Stanojevic (2014)RS0466RS0466KF157468None   I15V, M36I, L63V, I64VB
Alexiev (2015)11BG145811BG1458KJ765561None   K14N, L19T, K20R, E35D, M36I, R41K, R57K, I62V, L63V, E65D, T74S, L89MB
Chin (2015)NMC20130102013010KM820301None   L10I, K14R, R41K, I62V, L63V, H69Y, V77I, I93LB
 NMC20130762013076KM820367None   I15V, N37S, L63V, V77IB
Guimaraes (2015)RDSPE367RDSPE367KT355953None   L10I, T12A, I13V, L19I, E35D, M36I, L63V, H69Q, L89MB
Guimaraes (2015)BRSP547-14BRSP547-14KP115542None   G16E, E35ED, L63V, H69K, V77I, I93ILB
Lunar (2015)SI8285-11SI8285-11KF753734None   L10I, K14R, R41K, L63V, A71T, I72T, V77I, I93LB
 SI21002-11SI21002-11KF753724None   I13V, I15V, M36I, R41K, L63V, H69RB
Moura (2015)BRMA_185BRMA_185KF782723None   L10I, I15V, Q18IL, E35D, M36I, R41K, L63V, H69QB
Moura (2015)BRPI_17BRPI_17KF700959None   L10I, I62V, L63V, I93LB
Yan (2015)SMS_VMI146SMS_VMI146KP418591None  L33FI13V, K14R, N37S, Q61E, I62V, L63V, I64V, G68D, V77IB
Boillot (2016)MAK13MAK13KT315965None   T12S, L19V, M36I, N37D, R41K, D60E, L63V, I72VB
Darcissac (2016)V25PENNV25PENNKT998210None   K14R, N37S, R41K, L63V, I64VB
 Q46XEDCQ46XEDCKU052748None   L10I, I13V, N37S, R41K, I62V, L63V, I93LB
Hoenigl (2016)V0800044V0800044KU574407None   L10I, G16E, N37S, P39S, I62V, L63V, A71T, I93LB
 V0867551V0867551KU574456None   L63V, V77I, G94GS, F99FLB
 V1023903V1023903KU574521None   I62V, L63VB
 M1200394M1200394KU574317None   L63VB
 V0875819V0875819KU574464None   L63V, V77IB
 V0780880V0780880KU574400None   L10I, G16E, M36L, N37S, P39S, I62V, L63V, I64V, A71T, I93LB
 V0878135V0878135KU574466None   L63VB
 V0839901V0839901KU574437None   L63VB
 V0921088V0921088KU574485None   L63VB
 M1313529M1313529KU574365None   L10V, T12P, I15V, G16E, M36I, I62V, L63V, I93LB
Lima (2016)08PE07408PE074KX021095None   L10I, T12K, I15V, L19I, E35D, M36I, N37D, L63VB
 09PE18809PE188KX021015None   L10I, I15V, G16E, E35D, M36I, R41K, K45R, R57K, Q61N, L63V, I72T, P81T, G86W, R87KB
Panichsillapakit (2016)3ui/200205103ui None   L10I, K14R, N37D, R41K, L63V, V77I, I93LB
Pessoa (2016)10BR_RJ10610BR_RJ106KT427751None   L10V, K14R, L19I, N37S, L63V, V77IB
 10BR_PE09510BR_PE095KT427700None   I15V, L19V, E35D, L63VB
 10BR_PE04110BR_PE041KT427724None   T12N, I15V, L19I, M36I, R41K, L63VB
Pouran Yousef (2016)309309-03064KX466215None   T12P, G16E, I62V, L63V, E65D, I72V, V77VI, I93LB
 399110-02294KX466773None   R41K, R57K, I62V, L63V, C67CY, A71V, V77I, I93LB
 404809-02909KX466811None   L19I, K43R, L63V, V77IB