Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	L63V
Rx	PI-naive
IncludeMixtures	No

References	66
Patients	131
Isolates	136

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Schapiro (1996)	EV37	EV37_W0	AF013885	None		I62V, L63V, I93L	B
Patick (1998)	503-283	503-283B		None		L10I, I15V, L63V, I93L	B
Bacheler (2000)	LB4-P113	P113-0		None		L10I, I15V, L63V, I93L	B
Albrecht (2001)	ACTG364_1202	1202		None		E35D, R41K, L63V, A71V, I72IM, I93L	B
Gonzales (2001)	CA2106	CA7766	AY030813	None		L10I, L19I, M36I, L63V, H69HQ	B
	CA4794	CA11840	AY031453	None		R41K, I62IV, L63V, A71V, I72EV, V77I, I93L	B
	CA6556	CA16480	AY032462	None		I13V, I15V, K20I, M36I, N37D, L63V, I64M, L89M	B
Perno (2001)	PCF_Pat77	PCF1107	AF376564	None		I15V, M36I, L38LF, L63V, H69K	B
	PCF_Pat86	PCF272	AF376529	None		K14KR, G16GE, M36I, R41K, R57K, D60E, L63V, I64V, E65D	B
Servais (2001)	JS98395	JS98395	AJ279674	None		N37A, L63V	B
Dumans (2002)	AD-14	AD-14	AF413833	None		Q18L, L63V, V77I	B
Gibb (2002)	DMG54	54_w0		None		K14KR, I15V, L19LI, L63V, H69IM, I93IL	B
		54_w25		None		K14R, I15IV, Q18QH, L19LI, L63V, H69IM, I93IL	B
		54_w48		None		K14R, I15V, Q18QHL, L63V, H69M	B
Machado (2002)	183	cdpol183	AF373720	None		T12S, K14R, I62V, L63V, I64V	B
	185	cdpol185	AF373722	None		I15V, L63V	B
Brindeiro (2003)	BRP2137	BRP2137	AY213433	None		E35D, R57K, Q61H, L63V, L89M	B
Maljkovic (2003)	MI_Pat61	00SE19853	AY165238	None		L10LI, T12TI, I13IV, K14KR, L33V, L63V, I64V, I93L	B
Shafer (2003)	A384_0917	0917a	EF548344	None		L10I, I15V, E35D, N37D, R57K, I62V, L63V, I66IM, A71T, V82I, I93L	B
	A384_0845	0845a	EF548460	None		L10I, I13V, L19T, L63V, A71T, V77I	B
	A384_1141	1141a	EF548990	None		L10I, I15V, L63V, H69Q	B
	A384_2531	2531a	EF549201	None		T12A, M36I, N37D, L38LF, L63V, I93L	B
Soares (2003)	BRRJ877	BRRJ877	AF527358	None		L10I, I15V, G16R, M36I, L63V, H69Q	B
Gulick (2004)	RG137	RG137w0		None		L10I, K14R, L33LV, E35ED, N37AT, R41K, R57RK, L63V, I64V, I93L	B
		RG137w18		None		L10I, K14R, L33V, E35ED, N37A, R41K, L63V, I64V, I93L	B
		RG137w27		None		L10I, K14R, L33V, N37A, R41K, L63V, I64V, I93L	B
	RG385	RG385w0		None		T12S, L19I, I62V, L63V, A71V, I72T, I93L	B
Kuritzkes (2004)	KDR_pat158	A0207	AY528024	None		N37D, L63V, V77VI	B
Grossman (2005)	24888	24888PR372		None		T12N, G16GR, L19I, Q61QH, L63V, K70R	B
Podzamczer (2005)	DP_401	DP_401m5		None		I15V, L63V, V77I, N83NY	B
Rhee (2005)	CA16543	CA39275	AY798264	None		L10I, L63V, I64V, C67S	B
Weber (2005)	WJ_pat7728	7728_W0	AY736114	None		L10I, I15V, L19I, R41K, D60E, Q61E, L63V, H69Q, V77I	B
		7728_W32	AY736115	None		L10I, I15V, L19I, R41K, D60E, Q61E, L63V, H69Q, V77I	B
Jayaraman (2006)	3-00-0111	3-00-0111		None		I15V, E35D, N37D, L63V, I93L	B
Lama (2006)	Pt3593	3593		None		T12K, I62V, L63V, V77I	B
	Pt5260	5260		None		L10I, T12P, L19I, L63V, C67Y, H69Q, A71V, I72T, I93L	B
	Pt7537	7537		None		L10V, L63V, K70R, I72T, L89M	B
Lindstrom (2006)	SIIDC0277	SIIDC0277		None		I15V, N37Q, L63V	B
	SIIDC0104	SIIDC0104		None		L10I, L63V, I93L	B
	SIIDC0154	SIIDC0154		None		L10I, L63V, I64V, I93L	B
	SIIDC0197	SIIDC0197		None		L10I, T12TA, I15V, G16GE, P39PT, L63V, I93L	B
Petroni (2006)	AP_ARRP021	AP_ARRP021	DQ206670	None		N37H, R41K, L63V	B
Brumme (2007)	1426	PRRT_1426	EF368736	None		I15V, I62V, L63V, C67S, I72V, V77I	B
Dilernia (2007)	F278	F278	EF120207	None		L10I, T12A, K14R, L63V, I64V, H69Q, V77I	B
Gonsalez (2007)	60	HIV_60	GU288774	None		L10I, I15V, N37E, R57RK, D60DE, L63V, C67S	B
	61	HIV_61	GU288742	None		L10I, I15V, G16A, N37E, L63V, C67S	B
Rios (2007)	CH46	MR_CH46	EF193937	None		L10I, T12P, I15IV, G16E, E35D, P39S, L63V, C67CG, I93L	B
Holguin (2008)	SP107-329080	SP107-329080	EU255453	None		N37NS, I62V, L63V, I72V, V77I	B
Lloyd (2008)	TX171	03HN_TX171	EU312909	None		L19I, L63V, I64V, I72V	B
	TX196	03HN_TX196	EU312926	None		T12S, L19I, N37S, L63V, K70R, V77VI	B
	TX205	03HN_TX205	EU312934	None		G16GE, L63V	B
	TX249	03HN_TX249	EU312969	None		T12TP, I15V, L19IT, L63V, I72T, V77I	B
Ndembi (2008)	IAEAM016	IAEAM016	EU306754	None		I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89M	B
Somi (2008)	KG-05-429	KG-05-429	JQ616977	None		I13V, K14R, K20M, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93IL	B
Brennan (2009)	A46	ARC-A46	EU711461	None		Q18E, L63V, I64V, K70R, V75I, V77I	B
Brumme (2009)	O9574	O9574	GQ372074	None		R41K, I62V, L63V, I93L	B
	P4576	P4576	GQ372086	None		I15V, M36V, I62V, L63V, T74S	B
	PRRT_4085	PRRT_4085	GQ303774	None		K14R, N37D, L63V	B
	PRRT_4142	PRRT_4142	GQ303831	None		L10V, T12P, L19I, E35D, N37NS, R41K, L63V, A71T, I93L	B
	PRRT_4178	PRRT_4178	GQ303867	None		L10V, T12P, N37S, R41K, W42W*, G51GE, L63V, G68GE, R87RK, L89M, I93L	B
Cardoso (2009)	BRGO3109	BRGO3109	FJ594159	None		G17D, R41K, I62V, L63V, H69K, A71T, I93L	B
Castillo (2009)	51	51PROT	GQ202971	None		K14R, N37DE, L63V, C67S, A71V, I72T, V77I, I93L	B
Cuevas (2009)	X2513_1	X2513_1	GU326117	None		L10S, T12P, L63V, I64V	B
	X2689_1	X2689_1	GU326173	None		T12P, K14R, R41K, L63V, A71V, I72M, V77I, I93L	B
de Sa-Filho (2009)	55361	55361Pgr	GQ294613	None		L10V, I15V, G16E, L19I, N37E, P39S, L63V	B
Dumans (2009)	97_05	97_05	FJ405103	None		Q2L, L10V, I13V, K14R, L33V, N37A, P39Q, L63V, I64V	B
Fujisaki (2009)	608	608	AB442274	None		L10I, T12P, I15V, M36L, N37S, R41RK, I62V, L63V, I64V, I93L	B
Nadai (2009)	129517	129517	EU839600	None		L19V, N37S, R41K, R57K, L63V	B
Smith (2009)	PI62	US2002PI62		None		L10I, K14R, N37D, R41K, L63V, V77I, I93L	B
	PI242	US1999PI242		None		L10I, K14R, I15V, N37D, R41K, L63V, V77I, I93L	B
	CR82	US2006CR82		None		L10I, T12P, I13V, I62V, L63V, A71T	B
	CR173	US2006CR173		None		G16E, I62V, L63V, I64IM, V77I, I93L	B
Vercauteren (2009)	pt2021	1214439289	GQ399003	None		L63V	B
	pt1892	1947360640	GQ399132	None		G16E, M36MI, N37S, I62V, L63V	B
	pt1873	1xa4qSFZvv	GQ399151	None		L10I, Q18R, N37S, R41K, I62V, L63V, A71T, I72T, V77I, I93L	B
	pt1556	3993935960	GQ399468	None		N37T, L63V	B
	pt1530	4093797321	GQ399494	None		L63V	B
	pt1385	4961244561	GQ399639	None		L10I, T12A, I13V, M36I, I62V, L63V, I64V	B
	pt1057	6897180640	GQ399967	None		L10V, E35D, R41K, L63V, A71V, I93L	B
	pt983	7369234238	GQ400041	None		L10I, K14R, L19I, N37S, R41K, I62V, L63V, I93L	B
	pt940	7604935324	GQ400084	None		I15V, L63V	B
	pt919	7741425074	GQ400105	None	T74TP	E35D, M36I, N37D, D60E, I62V, L63V, I64V, I72T	B
	pt452	Bz6I1lHzBf	GQ400572	None		T12P, L19I, L63V, I93L	B
Wallis (2009)	GT00349623	GT00349623		None		K14R, I15V, L19V, M36I, R41K, L63V, H69K, V82I, L89M, I93L	B
Wang (2009)	L8180	L8180	FJ469743	None		L19I, N37S, L63V, H69Q, V77I	B
Brennan (2010)	Pat088	ARC-A146	JN697291	None		N37D, R41K, D60E, L63V, E65D, V77I	B
Ragonnet-Cronin (2010)	PHAC_154	PHAC_154	HM468652	None		I15V, E35D, N37D, R57RK, L63V, A71T, V77I, I93L	B
	PHAC_287	PHAC_287	HM468785	None	V11VI	T12P, I15V, M36I, N37D, R57K, L63V, C67W	B
	PHAC_377	PHAC_377	HM468875	None		L10I, T12TKPQ, I15V, R41K, L63V, V77I, I93L	B
	PHAC_392	PHAC_392	HM468890	None		L10V, I15V, R41K, L63V, V77I, I93L	B
Yebra (2010)	256100	05SP0256100	FJ481796	None		T12TP, I13V, I15IV, M36I, N37E, R57RK, L63V, H69HY, V77VI, L89M	B
Chibo (2011)	S4	S4	JF895191	None		L10V, I15V, L19I, N37S, R41K, Y59YF, L63V, E65D, H69Y	B
	S150	S150	JF895337	None		L10V, T12A, I15V, L19I, E35D, N37E, L63V, E65D, H69Y	B
de Medeiros (2011)	Pat006	RS072	JF487835	None		T4H, L5F, L10I, T12K, I15V, E21G, L24F, M36I, N37K, R41N, L63V, H69K, I93L	B
	Pat035	RS077	JF487864	None		I15V, E35D, N37S, R41K, L63V, H69K, L89M	B
Ferreira (2011)	BRMT2244	BRMT2244	HQ638790	None		L10V, T12Q, K14R, I15V, M36I, N37E, R41K, L63V, H69R, K70R	B
Graf (2011)	SC142	SC142	JF774061	None		L19I, N37T, R41K, L63V, H69K, V77I	B
Hamers (2011)	CP076300708	CP076300708	HQ994921	None		L10I, I13V, I15IV, G16E, E35D, D60E, L63V, I64V, H69Q, I72V	B
Rolland (2011)	1400	consensus_1400	JF320043	None		T12P, I15V, L19I, P39S, L63V, T91V, I93L	B
Santos (2011)	J159	J159_PR_RT	JN010549	None		L10I, I13V, L19I, N37S, R41K, I62V, L63V	B
	J350	J350_PR_RT_CN	JN010733	None		L10I, G16E, N37A, P39S, R41K, I62K, L63V, V77I, I93L	B
Avila-Rios (2012)	JC00MG0OTW	JC00MG0OTW	KC169106	None		M36MI, N37ND, R41RK, L63V, I64V, K70R	B
	M800FE4I7F	M800FE4I7F	KC169269	None		I15IV, N37D, L63V, I93L	B
	ME00M9ILO1	ME00M9ILO1	KC169291	None		L10I, M36I, L63V, I64V, H69Q	B
	OE00M77IUB	OE00M77IUB	KC169481	None		L10I, M36MI, R41K, L63V, I64V, I93L	B
	PCT0X98TJ7	PCT0X98TJ7	KC169583	None		I15V, M36MI, R41K, L63V, K70R	B
	V000MU4ET9	V000MU4ET9	KC169692	None		T12S, I15V, L19I, M36MI, N37S, R41K, L63V	B
	D000MD1OJX	D000MD1OJX	KC168318	None		T4TN, L19I, R41K, L63V, I72V, V77I, R87RK	B
	D000MIBCUV	D000MIBCUV	KC168352	None		I15V, L63V, V77I, I93L	B
	E2E0MF5QU9	E2E0MF5QU9	KC168723	None		L10I, I13V, M36MI, N37D, R57K, L63V, H69Y, A71V, I72T, I93L	B
	GA00MF8IRP	GA00MF8IRP	KC168883	None		I15V, L63V, K70R, V77I	B
	J800MBEKV4	J800MBEKV4	KC169078	None		Q18E, M36I, N37HQ, I62V, L63V	B
De Gascun (2012)	IRL35902	IRL35902	JN622487	None		I15V, E35D, N37E, L38LW, D60DA, Q61QP, I62V, L63V, H69K, A71T	B
	IRL41024	IRL41024	JN622502	None		K14KR, I15IV, E35D, N37E, I62V, L63V, E65ED, H69K, A71T	B
Delwart (2012)	477-0278-4	477-0278-4	JN214906	None		T12TI, I15V, G16GE, R41K, I62V, L63V, V77I, I93L	B
	479-1062-6	479-1062-6	JN215039	None		I15V, M36I, R41K, L63V, I72V	B
	477-3191-5	477-3191-5	JN215130	None		N37S, R41K, L63V	B
Escobar (2012)	ES90	ES90	JX466963	None		K14M, L19R, R41K, D60E, L63V, E65D, V77I, L89I	B
	ES146	ES146	JX467010	None		L10I, I13V, I15V, L63V, I64V, I72T, V77I, I93L	B
Gaspareto (2012)	LBS41	LBS41PT	HM752172	None		T4S, T12K, I15V, M36L, R41K, Q61N, I62V, L63V, I64M, E65D	B
Murillo (2012)	11157	11157	KC412745	None		I15V, L19I, N37T, R41K, L63V, E65D, V77I	B
Ragonnet-Cronin (2012)	C05_017	C05_017	JX014981	None		I15V, E35D, N37D, L63V, P81T, I93L	B
	C06_045	C06_045	JX015004	None		I15V, E35D, N37D, L63V, G68E, A71V, I93L	B
	E10_054	E10_054	JX015062	None		T12I, I15V, E35ED, N37D, L63V, I93L	B
	F06_021	F06_021	JX015071	None		L10LIV, K14KR, L19LQ, R57RK, L63V, E65ED, A71AT	B
Alencar (2013)	SP2-0016	SP2-0016	JQ237971	None		K14KR, E35ED, N37NK, R41K, L63V, I64V, K70R	B
	PE2-0041	PE2-0041	JQ238055	None		T12N, I15V, L19I, M36MIL, R41K, L63V, V77VI	B
	PE2-0095	PE2-0095	JQ238211	None		I15V, L19V, E35D, L63V	B
Ferreira (2013)	BR09SP107	BR09SP107	HM534012	None		L10I, K14R, I15V, L19I, M36I, N37E, L63V, V77I, I93L	B
	BR09SP78	BR09SP78	HM534061	None		L10I, L63V, H69Q, I93L	B
Frentz (2013)	EHR-07738	EHR-07738	JX299667	None		L63V	B
	EHR-35815	EHR-35815	JX300140	None		L63V	B
	EHR-58877	EHR-58877	JX300524	None		E35D, L63V, I64V, E65D	B
	EHR-64740	EHR-64740	JX300629	None		L10I, N37S, R41K, L63V, K70R, I93L	B
	EHR-81373	EHR-81373	JX300928	None		I15V, R57K, L63V, I72V, V77I	B
Hawke (2013)	2547988 H	2547988 H	KC238089	None		L10I, I15V, E35D, N37NT, I62V, L63V, I93L	B

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