<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation L63C
Rx >= 1 PI
IncludeMixtures No
References 32
Patients 121
Isolates 149
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Molla (1996)RTV-305RTV305W12 RTV12V82T I15V, N37E, L63CB
Craig (1998)Craig-pt1616W44 SQV44L90M L10I, T12A, K14R, D60E, L63C, I64V, A71V, I93LB
Murphy (1999)ACTG347_0129129_PR_w12 APV12  L10LV, K14R, R41K, D60E, I62V, L63CB
Atkinson (2000)BA20BA20AF247865NFV16D30N, M46IN88DM36I, K45R, L63C, I64VB
Balotta (2000)CB-142CB-142AF251962SQV, RTV M46MI, I54IV, V82M, L90MQ58EI13V, M36I, G52GS, I62V, L63C, I64VB
 CB-161CB-161AF251978SQV, RTV, IDV M46I, I54V, V82A, I84VL24IL10I, E35D, M36I, I62V, L63C, I64V, A71AV, N83XB
Baxter (2000)GART-NG69GART-69 PI, IDVNAI54IV, V82A L10I, R41K, L63CB
Sevin (2000)SA-140860dSA-140860dAF226106SQV121L90LM L19E, N37NS, D60DE, I62IV, L63C, A71V, T74TA, V77I, I93LB
Delgado (2001)ED_V16ED_V16AY016827SQV   K14R, L19I, N37S, L63C, V77IB
Fitzgibbon (2001)JF-11JF11-M5AF442163IDV, NFV   N37D, I62V, L63C, T74S, V77IB
  JF11-M13AF442173IDV, NFV M46I, L90M I13V, N37D, I62V, L63C, T74S, V77IB
Gonzales (2001)CA798CA1440AY030428SQV, IDV96I54V, V82F, L90MG73CL10I, I15V, K20I, E35D, M36I, R57K, Q61N, I62V, L63C, T74SB
 CA1171CA3179AY030477SQV, NFV56D30N I15V, M36I, L63C, A71V, I93LB
 CA1259CA3027AY030488IDV, SQV, RTV65M46L, G48V, I54V, V82AQ58EL10I, L63C, A71V, V77I, Q92K, I93LB
 CA1440CA3850AY030578SQV, NFV, RTV, IDV, APV13G48V, I54T, V82A, L90ML33F, F53FLL10I, I13V, E35D, M36I, N37Q, R41K, I62V, L63C, I64V, A71T, T74TS, V77I, I93LB
 CA1545CA4418AY030662IDV115  N37T, R41K, L63C, I64V, I93LB
 CA1867CA4997AY030771SQV, IDV152M46L, G48V, I54V, V82A L10I, L19I, R41K, K55R, L63C, V77I, I93LB
 CA2099CA7749AY030806IDV, SQV, NFV99M46L, I54V, V82AL10FI, L24LII15V, K20R, E35D, M36I, R41K, R57K, I62V, L63C, A71V, L89M, I93LB
 CA2193CA7963AY030818NFV, IDV84M46I, V82AL24I, Q58EL10LI, L63C, I64V, T74R, V77IB
 CA3955CA9513AY030953IDV54M46L, V82T K20I, L63C, A71AV, V77IB
 CA3966CA9729AY030964NFV, UnknownNA  I15IV, E35D, M36I, N37D, I62IV, L63CB
 CA4088CA9790AY031082IDV, NFV140M46L, V82AL10FI, L24I, Q58QEI15V, M36I, L63C, I64V, T74TSB
 CA4125CA9832AY031114IDV, SQV, NFV138M46I, I54V, V82AL10F, F53LL63C, L89MB
 CA4888CA12084AY031528NFV49D30DN, M46MIL10LF, T74TPI15V, E35D, N37S, D60E, I62V, L63CB
 CA4990CA12578AY031565SQV, IDV156I54M, L90M L10I, E35D, N37D, D60E, I62V, L63C, A71T, V77I, I93L, C95FB
 CA6790CA17078AY032523SQV, RTV17  E35D, R41K, L63C, H69Q, V82IB
Kempf (2001)DK-594DK-594 SQV, IDV, NFV, RTV150M46I, L90MG73SL10LI, K20X, I62IV, L63C, H69X, A71V, V77I, I93LB
Kantor (2002)CA2193CA10793AY047447NFV, IDV, SQV111M46I, V82A, I84IVL24I, Q58EL10I, L63C, I64V, T74R, V77IB
 CA3955CA11046AY047457IDV, NFV72M46I, V82AT K20I, K55KR, L63C, A71X, V77I, I93ILB
Margot (2002)MM-2420366222420366221 PINAG48V, I54V, V82A L10I, E35D, L63C, I64VB
 MM-4341366504341366501 PINA  T12A, I62V, L63CB
Romano (2002)MZ-pt26pt26-t0AF493361RTV, SQV, NFV, IDV   Q7R, K14V, L19Q, L24LV, L63CB
  pt26-t1AF493400RTV, SQV, NFV, IDV, LPV G48V, I54A, V82AL33FL10I, K14I, I15V, G16E, L19Q, K20M, E35D, M36I, N37D, I62V, L63C, I64V, T74A, I85VB
Tural (2002)880723880723 IDV29  L10V, E35D, N37D, L63CB
Shafer (2003)A384_17691769bEF548774NFV24  L63CB
 A384_39183918cEF549181NFV19  L10I, T12S, N37C, I62V, L63CB
Wu (2003)CA798CA35544AY798445SQV, IDV123I54V, V82F, L90MG73CL10I, I15V, K20I, E35D, M36I, R57K, Q61N, I62IV, L63C, T74SB
  CA13183AF544420SQV, IDV, RTV146I54V, V82F, L90MG73CL10I, I13IV, I15V, K20I, E35D, M36I, R57K, Q61N, I62V, L63C, T74SB
 CA1545CA7721AF544500IDV130  N37T, R41K, L63C, I64V, I93LB
 CA1867CA12603AF544520SQV, IDV204M46L, G48V, I54V, V82AF53FLL10I, L19I, R41K, K55R, L63C, A71AT, V77I, I93LB
 CA4125CA16200AF544549IDV, SQV, NFV184M46I, I54V, V82AL10F, F53LR41RK, K43KE, L63C, T74S, L89MB
 CA7088CA17556AF544603SQV, IDV, NFV188D30N I15V, K20R, E35D, M36V, N37S, D60E, I62V, L63CB
Dumans (2004)222222AY390040RTV19  L63C, E65G, I72V, V77IB
 225225AY390056NFV, SQV, RTV, APV83  L10I, I13V, N37S, R41K, L63C, I64V, V77IB
 250250AY390042NFV125L90M N37C, L63C, V77IB
 197197AY390041SQV, RTV65  N37S, L63C, I64V, V77IB
Gomez-Carrillo (2004)9427394273AY365497PINA  L10I, T12TP, I13V, I15V, T26TP, T31TP, M36I, L63C, I64V, H69QB
 9905599055AY365594PINA  L33V, N37S, L63C, I72V, L89MB
 107168107168AY365765PINAM46L, I54IV, V82TL10FT12K, I15V, G16E, L19I, L63C, I64V, H69HR, T74AS, V77I, I85VB
 108438108438AY365787PINA V11VIL10I, G16GE, K20KR, M36I, R41K, R57K, Q61N, L63C, I93LB
Rhee (2004)CA1171CA2659AF085128SQV, NFV66D30N I15V, M36I, L63C, A71V, I93LB
Rhee (2005)CA798CA9536AY796479SQV, IDV131V82F, L90MG73CL10I, I15V, G16E, K20I, E35D, M36I, R57K, Q61N, I62V, L63C, C67Y, T74SB
  CA23644AY796480SQV, IDV, RTV, LPV218I54V, V82A, L90MG73CL10I, I15V, G16E, K20M, E35D, M36I, R57K, Q61N, L63C, T74S, I85V, I93LB
 CA1259CA13627AY796562IDV, SQV, RTV, NFV169M46I, G48V, I54V, V82A, I84VQ58EL10I, L63C, H69HY, A71V, V77I, Q92K, I93LB
  CA37783AY796563IDV, SQV, RTV, NFV, LPV336M46L, G48V, I54V, V82A, I84VQ58EL10I, K20R, M36I, L63C, A71V, Q92K, I93LB
 CA2193CA37795AY796883NFV, IDV, SQV, APV, LPV324M46MI, V82VA, I84IVL24LI, Q58QEL10LI, R57RK, L63C, I64IV, T74TR, V77VIB
 CA3955CA33338AY796962IDV, NFV, SQV, RTV, APV207M46IL, G48GV, V82A, I84V, L90LM L10I, K20I, L63C, A71V, V77I, T91TSB
 CA3966CA16231AY796966NFV, Unknown, APV>34  I15IV, E35D, M36I, N37D, I62V, L63CB
  CA33312AY796967NFV, Unknown, APV>34  E35D, M36I, N37D, I62IV, L63CB
 CA4125CA34059AY797022IDV, SQV, NFV, RTV, APV319M46I, I54V, V82AL10F, F53LN37D, L63C, T74S, L89MB
  CA40820AY798426IDV, SQV, NFV, RTV, APV371M46I, I54V, V82AL10F, F53LN37D, L63C, T74S, L89MB
 SWC-0835P835-823 IDV27M46L, V82A L10I, L63C, I72VB
  0835-2529 IDV, NFV, Unknown>93  L63C, V77I, I93LB
 SWC-66596659-1914 IDV, Unknown>6  N37S, L63C, I64V, E65DB
 SWC-3834P3834-170 IDV24V32I, M46I, I47V, V82A T12K, L19I, E35D, N37E, L63CB
  P3834-368 IDV36V32I, M46I, I47V, V82A T12K, L19I, E35D, M36X, N37E, L63CB
  P3834-641 IDV, SQV, RTV53M46I, G48GV, I54IV, V82A, L90M L10I, L19I, E35D, M36X, N37E, L63CB
  3834-1270 IDV, SQV, RTV, NFV93M46I, I54V, V82A, L90M L10I, T12K, L19I, E35D, M36I, N37E, I62V, L63C, I93L, C95FB
  3834-2248 IDV, SQV, RTV, NFV150M46I, I54V, V82A, L90M L10I, T12K, L19I, K20R, E35D, M36I, N37E, R41K, I62V, L63CB
 CA6883CA17061AY797480IDV, NFV113D30NL10LF, N88DK14R, I15V, E34D, M36I, N37D, R57K, L63C, A71VB
 CA8082CA20621AY797691SQV152L90LM L10LI, I15V, G16E, L63C, T74TA, V77I, I93LB
  CA33584AY797692SQV, APV214V82AQ58QEL10I, I15V, G16E, K20KT, R41RK, I54X, L63C, T74X, V77I, I93LB
 CA9942CA24592AY797945IDV, SQV, RTV66  L63C, A71TB
  CA42731AY797946IDV, SQV, RTV66  E35ED, L63C, A71TB
 CA18431CA43009AY798306IDV123  L63CB
Baxter (2006)12-11431143-30403DQ876028PINA  L10LI, G16GE, K20KR, E35D, L63C, I64VB
 12-21002100-30613DQ876031PINAV32VI, M46I, I54L, V82VAIT, I84VQ58EL10I, T12K, I15V, G16A, L19I, K20R, M36I, N37A, G51A, L63C, I66F, A71V, T91SB
 12-30033003-30219DQ876097PINAM46I, I54V, V82A, L90MV11I, G73SL10I, I15V, G16E, L19Q, K20I, E35D, M36I, N37E, K55R, I62V, L63C, A71I, I72R, I93LB
 12-13091309-30505DQ876224PINAG48V, I54V, L90MK43TL10I, I15V, G16E, K20R, E35D, M36I, P39S, R41K, I62V, L63C, I93LB
 12-18291829-30529DQ876388PINAM46ML, I50IV, V82VAL23LIL10LV, T12K, L19LI, R41K, L63C, A71AV, V77VI, I93LB
 12-21962196-30630DQ876436PINAM46I, G48V, I54T, V82S L10V, I15V, G16GE, K20R, E35D, M36I, N37S, P39PS, R41K, R57K, I62V, L63C, A71V, I72V, T74S, V77I, I93LB
 12-19691969-30626DQ876454PINAD30N, V32I, M46I, I47V, I54L, I84V, L90ML10F, L33F, F53L, N88DI13V, E34Q, I62V, L63C, T74E, V77I, P79A, L89MB
 12-22142214-30722DQ876457PINAM46L, I54V, V82VA, I84IV, L90ML10FI13V, K20I, L24*, E35D, M36I, I62V, L63C, I64V, T74S, L89I, T91SB
 12-13551355-30527DQ876495PINAM46L, I54V, V82AV11I, L24I, L33F, F53L, G73SL10I, I13IV, I15V, G16E, M36ML, N37S, K55R, I62V, L63C, A71VB
 12-21082108-30619DQ876636PINAM46I, I54V, L76V, V82A, I84V L10I, I15V, K20R, M36I, N37D, K43S, Q61QK, I62V, L63C, H69R, A71V, I72T, T74AS, I93LB
 12-21752175-30730DQ876674PINAI54V, V82A, L90M L10I, K20KLMQ, N37D, R41K, D60E, I62V, L63C, I64V, A71V, V77I, I93LB
 12-20172017-30701DQ876696PINAM46L, I54V, V82FG48E, F53LL10I, E35D, M36V, N37H, R41N, L63C, I64V, V77I, I93LB
 12-23422342-30730DQ876709PINAM46I, I54V, V82A, L90LML10F, L33F, T74PI13V, I15V, G16E, L19I, K20T, E35G, M36I, P39T, R41RK, R57K, I62V, L63C, A71V, I72T, I93LB
 12-20942094-30717DQ876931PINAM46L, G48V, I54CST, V82A L10I, N37ND, R41RK, L63C, A71V, V77I, I93LB
 12-31513151-30815DQ877161PINAV32VI, M46MI, I47IV, V82VAIT, I84VL10LF, Q58QEI15V, K20R, E35D, M36I, N37D, K45KI, L63CB
 12-31733173-30812DQ877202PINAM46I, I84V, L90M L10I, I62IV, L63C, I64V, V77VI, P79ADNT, L89MB
 12-30343034-30306DQ877214PINAM46L, V82AL24IL10I, K55R, I62V, L63C, T74S, L89MB
 12-30663066-30407DQ877225PINAM46I, I54V, I84V, L90ML10F, V11VI, Q58E, G73TL19IT, K20I, M36I, I62V, L63C, I64IV, H69R, A71V, V77VI, I93LB
 48-10121012-30618DQ877260PINA  L63C, V77VIB
 48-11621162-30814DQ877267PINAM46L, I54V, L76V, V82AL23IL10I, I15V, K20R, E35D, M36I, N37D, R57K, Q61N, L63C, L89MB
 48-10721072-30625DQ877333PINAM46I, I54V, V82AL24I, F53LL10I, I15V, G16E, K20R, E35D, M36I, R41K, K43I, K55R, R57K, Q61D, L63CB
 48-11061106-30625DQ877395PINAD30DN K14R, I15IV, G17E, K20KR, E35D, M36I, R41K, R57K, Q61N, L63C, E65ED, A71AV, V75VI, I93ILB
 48-11391139-30814DQ877399PINAM46L, G48V, I54T, V82AL24IL10I, K20R, E35D, M36I, N37DE, R41K, K43R, R57K, Q61N, L63C, T74S, L89MB
 48-32153215-30514DQ878125PINAV32I, M46I, I47V, I54M, I84V, L90ML10F, L33F, F53L, T74P, L89VI13V, L19V, K20R, E35D, M36I, N37D, L63C, I66F, A71VB
 48-32363236-30526DQ878143PINAI54LV, V82F, L90ML33F, Q58EL10V, I13V, I15V, G16E, K20R, E35D, M36I, R41RK, K55Q, I62V, L63C, I64V, V77VI, I93LB
 48-33103310-30909DQ878214PINAM46L, I54V, V82AL24IL10I, I15V, K20R, E35D, M36I, N37D, K55KR, I62V, L63C, I64V, T74SB
 48-60386038-30428DQ878637PINAM46MI, G48AV, I54V, L76V, V82SL24I, L33F, F53FL, Q58EL10I, I13V, G16E, R41RK, K55R, L63C, V77I, L89MB
 48-61366136-30924DQ878717PINAV32I, M46L, I47IV, I54M, V82A, L90MV11VI, K43T, L89VL10I, I15V, G16A, N37D, L63C, A71V, I72M, G73D, I85V, Q92KB
 48-70177017-30716DQ878900PINAV32I, M46I, I47V, I54V, V82A, L90ML33F, F53L, G73SL10V, I13V, K14R, G16E, K55R, L63C, A71V, I72IK, V77IB
 48-71577157-30604DQ878995PINA  I15V, N37C, I62V, L63C, V77IB
 48-71627162-30609DQ879000PINAV32I, M46I, I54V, V82A, L90ML33F, F53L, T74PL10I, I13V, K43I, K55R, L63C, A71V, T91SB
 48-71757175-30806DQ879012PINAM46I, I54V, L76V, V82A L10I, I13V, G16E, K20R, M36I, L63C, L89I, I93ILB
 48-72047204-30829DQ879029PINAG48V, I54T, V82A, L90ML33FL10I, G16GE, K20R, E34Q, E35D, M36I, N37E, R41K, I62V, L63C, A71V, I93LB
 48-90999099-30930DQ877663PINAM46I, I54V, V82A L10V, T12N, I15V, L19S, K20I, E21K, E35D, M36I, N37E, R57K, Y59F, Q61N, I62V, L63C, T74SB
 48-91399139-30925DQ877733PINAM46L, G48A, I54V, V82S L10V, G16A, K20R, E35D, M36I, I62V, L63C, A71V, T74S, I93LB
 48-72317231-30930DQ879044PINAI54AV, V82AL24I, L33F, F53LL10I, I13V, G16E, E34EQ, M36L, N37NS, K55KR, I62V, L63C, A71AV, I72V, T74A, L89IB
Mo (2006)HM_V4HM_V4 SQV, RTV M46L, I84V L10I, L63C, V77I, P79ASB
Eyer-Silva (2007)BRSQ4804BRSQ48EF042653LPV35  K14R, G17E, N37S, L63C, V77I, L89F, I93LB
von Wyl (2007)1374822140EF449869PINA  T12V, I15V, R41K, L63C, V77I, I93LB
 1405868658EF449959RTV, PINA  T12M, I15V, R41K, L63C, V77I, I93LB
Riddler (2008)RG1791RG1791w74 LPV74  I15V, R41K, L63CB
 RG29397RG29397w32 LPV32 L33FI13V, K14KE, D60E, L63C, V77IB
  RG29397w44 LPV44 L33FI13V, D60E, I62V, L63C, V77IB
Cardoso (2009)3115BRGO3115FJ638453PINAM46I, I54V, L76V, V82AL24I, Q58EL10I, T12P, I15V, G16E, K20M, E35D, M36I, N37NK, Q61D, L63C, L89MB
Dau (2010)05502A05502AGU581665PINA  K20R, M36I, I62V, L63C, V82IB
 06167A06167AGU581714PINAI84V, L90ML33LI, G73SL10I, I15IV, K20I, M36I, R41K, I62V, L63C, A71V, I72L, I85IVB
 06549A06549AGU581758PINA  I13V, I15V, G16E, N37S, L63CB
 07314A07314AGU581836PINAM46I, I54V, L76V, V82A, I84V L10I, I15V, K20R, M36I, N37D, K43S, I62V, L63C, A71V, I72T, T74A, I93LB
 12960A12960AGU582068PINAI54V, V82A L10V, I15V, K20R, M36I, N37D, I62IV, L63C, H69R, K70R, A71V, I93LB
Rangel (2010)HIV247pHIV247pGU807506PINAD30NN88DL10I, I13V, K20R, E35D, M36I, R57K, I62V, L63C, I64MV, I66F, A71V, I72VB
Jones (2012)128054128054JN669448PINA  L63C, V77I, I93LB
 141149141149JN669596PINA  K14R, K20R, M36I, N37D, I62V, L63C, H69HRB
 143099143099JN669637PINA  L10V, T12N, K14R, I15V, E35ED, M36I, N37E, R57K, D60E, Q61D, L63C, I72TB
 143731143731JN669645PINAM46I Q7H, L10V, I13IV, E34D, M36I, L63C, I64V, V77I, I93LB
 144783144783JN669649PINA  I15V, G16GE, Q18QE, E35D, M36I, L63C, I72VB
 148401148401JN669712PINA  T12K, L63C, V77IB
 155276155276JN669837PINA  K20R, M36I, N37D, L63CB
 165823165823JN670116PINAM46L, V82TL10FT12K, I15V, G16E, L19I, K55R, L63C, I64V, T74A, V77I, I85VB
 169084169084JN670193PINA  G16E, K20KR, R41RG, I62V, L63C, I72M, V77VIB
 172624172624JN670295PINA  K14R, K20R, M36I, N37D, I62V, L63CB
 177499177499JN670448PINA  T12N, I15V, G17E, L19M, K20M, M36I, N37E, L63CB
 181333181333JN670573PINAV32I, M46L, I47V, I54M, V82A, I84IVL24I, K43TL10Y, I15V, G16E, L19I, K20R, E35D, M36I, I62IV, L63C, I64V, A71V, V77VIB
 182834182834JN670626PINAV32I, M46I, I47V, I54M, V82AL10F, K43TK14R, K20R, E35D, M36I, N37D, K55R, R57K, L63C, I64V, A71V, I72TB
 185252185252JN670699PINAI54V, V82CL33FT12K, I13V, K14N, G16A, Q18H, L19I, K20KR, M36I, I62IV, L63C, I72IV, T74A, L89MB
 189585189585JN670778PINAD30NL33F, N88DI13V, I15V, L19I, K20R, E35D, M36I, P39PL, R41K, R57K, D60E, Q61D, L63C, A71V, I93LB
 193241193241JN670889PINAI54L, I84V L10V, E35D, M36I, R41K, L63C, A71V, I72T, I93LB
 197151197151JN671062PINA  L10V, T12TAEK, E35D, M36MI, R41K, L63C, A71V, I72IT, V77I, I93LB
 201914201914JN671243PINA  L10V, I15V, E35D, M36I, L63CB
 202750202750JN671292PINA  L10I, I13V, E35D, M36I, N37D, R41K, R57K, D60DN, Q61D, I62V, L63C, C67DB
 203290203290JN671306PINAM46L E35D, N37H, R41K, I62IV, L63C, I64VB
 207625207625JN671441PINA  K14R, M36I, R57K, L63C, I64IVB
Mollan (2012)MK104MK104w25 RTV, ATV25  L19I, E35D, L63C, V77I, I93LB
 MK247MK247w116 RTV, ATV116  I15IV, E35ED, M36I, L63CB
Grossman (2014)16951695KC213607LPV52  I15S, G16R, M36IL, I62V, L63CB