<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation I54S
Rx >= 1 PI
IncludeMixtures No
References 11
Patients 83
Isolates 98
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Balotta (2000)CB-199CB-199AF252052SQV, NFV, IDV G48V, I54S, V82A L10I, L63P, A71V, V77I, I93L, C95CWB
Gonzales (2001)CA1469CA3917AY030604SQV, IDV, NFV119G48V, I54S, V82AM46VL10I, G16GA, N37D, L63P, A71I, V77I, I93LB
 CA5478CA13553AY032017PINAG48V, I54S, V82A L10I, I15V, L63Q, I64V, A71V, I93LB
Romano (2002)MZ-pt17pt17-t1AF493392SQV, RTV, NFV, LPV G48V, I54S, V82A, L90M T4S, L10I, L19V, K20R, M36I, N37D, I62V, L63P, I64V, H69IB
Holguin (2003)SP_LP12SP_LP12AF455610PINAI54SF53LV56L, L63P, H69QB
Wu (2003)CA1469CA9609AF544484SQV, IDV, NFV, RTV164G48V, I54S, V82AM46VL10I, G16A, N37D, L63P, A71I, V77I, I93LB
Mo (2005)91249124_d1 PINAG48V, I54S, V82A L10I, E34Q, I62V, L63P, A71V, T74S, V77I, I93LB
  9124_d59 PI, LPVNAG48V, I54S, V82A L10I, E34Q, I62V, L63P, A71V, I72V, T74S, V77I, I93LB
  9124_d164 PI, LPVNAG48V, I54S, V82A L10I, E34Q, I62V, L63P, A71V, I72V, T74S, V77I, I93LB
  9124_d339 PI, LPVNAM46MIV, G48V, I50V, I54S, V82AL33LFL10I, E34Q, I62V, L63P, A71V, I72V, T74S, V77I, I93LB
Rhee (2005)CA634CA38020AY796450SQV, IDV, RTV, Unknown, APV, LPV>355M46I, G48V, I50V, I54S, V82AL33F, K43TL10I, K20R, E34T, E35D, M36I, N37D, I62V, L63P, A71V, I72V, V77I, I85V, I93LB
  CA38022AY796451SQV, IDV, RTV, Unknown, APV, LPV>355M46I, G48V, I50V, I54S, V82AL33F, K43TL10I, K20R, E34T, E35D, M36I, N37D, I62V, L63P, A71V, I72V, V77I, I85V, I93LB
  CA42683AY796452SQV, IDV, RTV, Unknown, APV, LPV>355M46I, G48V, I50V, I54S, V82AL33F, K43TL10I, K20R, E34T, E35D, M36I, N37D, I62V, L63P, A71V, I72V, V77I, I85V, I93LB
 CA1469CA11831AY796712SQV, IDV, NFV, RTV, APV189G48V, I54S, V82A L10I, G16GA, N37D, L63P, A71I, V77I, I93LB
  CA20270AY796713SQV, IDV, NFV, RTV, APV248M46L, G48V, I54S, V82A, I84IVL33FL10I, G16A, N37D, D60DE, L63P, A71I, V77I, I93LB
 SHNY-13SHNY-13 PINAM46L, G48M, I54S, V82AL33FL10I, I13IV, L63P, A71V, I93LB
Baxter (2006)12-30883088-30501DQ876101PINAM46I, G48V, I50V, I54S, V82ACGS, L90LM L10I, E34Q, Q61H, L63P, I64V, A71V, V77I, I93LB
 12-40464046-30514DQ876151PINAG48V, I54S, V82A, L90ML33FL10I, I13V, K20R, E35D, M36I, R41K, I62V, L63P, A71I, I72M, I93LB
 12-40024002-30124DQ876158PINAG48MV, I54S, V82A, L90ML33F, K43TL10V, I13V, Q18QH, K20R, L24LF, E35D, M36I, N37D, I62V, L63P, A71I, I93LB
 12-40134013-30203DQ876169PINAM46I, G48V, I50V, I54S, V82AL33F, L89VL10V, I13V, Q18QH, K20R, E35D, M36L, N37D, L63P, A71V, I72M, I93LB
  4013-30815DQ879136PI, RTV, TPV>28M46I, G48V, I54S, V82T, I84VL33F, L89VL10V, I13V, Q18H, K20R, E35D, M36L, N37D, L63P, A71V, I72M, I93LB
 12-10161016-30428DQ876233PINAM46L, G48M, I54S, V82A, L90LML33FL10I, G16A, L19LV, E34Q, N37D, Q61K, I62V, L63P, A71I, T74S, V77I, Q92S, I93LB
 12-10251025-30321DQ876284PINAG48V, I54S, V82SK43TL10I, I15V, G16A, K20T, L38LF, R41K, L63P, I64V, A71V, T74S, V77I, I85V, I93LB
 12-18041804-30528DQ876295PINAM46L, G48V, I54S, V82AL33F, Q58QE, G73S, L89VL10I, V11VL, G16A, I62V, L63P, I64IL, A71V, T74S, I93LB
 12-23712371-30730DQ876343PINAG48V, I54S, V82A, L90ML33F, Q58EL5F, L10I, I13V, E34Q, N37NS, D60E, I62V, L63P, H69R, A71L, V77I, I93LB
 12-18321832-30623DQ876390PINAM46I, G48V, I54S, V82AL33F, G73SL10I, I13V, I15V, L63P, A71V, I72M, V77VI, I93LB
 12-13391339-30416DQ876443PINAG48V, I54S, V82A, I84VL33F, Q58EL10I, I13V, L63P, A71V, I93LB
 12-11001100-30305DQ876513PINAM46L, G48V, I54S, V82AL33FL10I, I13V, R41K, K43I, I62V, L63P, H69Y, A71V, I72IT, V77I, I93LB
 12-18751875-30528DQ876534PINAM46*L, G48V, I54S, V82A L10I, K14KR, N37D, L63P, K70KE, A71V, V77I, I93LB
 12-11081108-30624DQ876559PINAG48V, I54S, V82AL24IL10I, I62V, L63P, H69R, A71V, I72V, V77IB
 12-24232423-30820DQ876748PINAG48V, I50V, I54S, V82AL33FL10V, I13V, E34Q, L63P, A71V, I72V, V77I, I93LB
 12-11171117-30310DQ876773PINAG48M, I54S, V82FL33F, Q58EL10V, I13V, K20Q, M36I, I62V, L63P, A71V, V77I, I93LB
 12-14661466-30606DQ876863PINAM46I, G48M, I50V, I54S, V82A, L90MK43TL10IV, E34Q, F53Y, I62V, L63P, I64V, A71V, I72V, V77I, I85V, I93LB
  1466-31229DQ879107PI, RTV, TPV>29M46I, I54S, V82T, L90MK43TL10I, E34Q, I62V, L63P, I64V, A71V, I72V, V77I, I85V, I93LB
 12-19461946-30528DQ876911PINAM46I, I54S, V82A, I84V, L90ML33FL10I, I13V, E34Q, N37D, L63P, I66F, A71V, Q92KB
 12-20562056-30616DQ876920PINAM46I, G48V, I54S, V82AL33LFL10IV, R41K, L63A, A71V, V77I, T91AB
 12-16331633-30313DQ876967PINAM46I, G48V, I54S, V82C, L90ML33LFL10I, R41K, L63GS, A71V, V77I, I93LB
 12-16401640-30320DQ876971PINAM46L, G48M, I54S, V82AL24I, L33F, K43TL10I, I13V, L19LI, M36L, F53Y, K55KR, I62V, L63V, I64V, T74AB
 12-15361536-30611DQ877001PINAG48V, I54S, V82AL33F, K43KTL10I, I13V, R41K, K45KQ, I64V, T74S, V77I, I93LB
 12-19841984-30602DQ877030PINAM46L, G48V, I54S, V82AL24I, L33FL10I, I13V, I62V, L63P, I64L, A71V, I72V, T74E, V77I, I93LB
 12-15591559-30603DQ877060PINAG48M, I54S, V82AL33LF, Q58QEL10I, L19T, K20R, M36I, I62IV, L63Q, I64V, A71V, T91AB
 12-17261726-30502DQ877094PINAM46L, G48V, I54S, V82A, L90ML33F, Q58EL10I, I13V, G16E, I62V, L63T, A71V, V77I, I93LB
 12-17381738-30617DQ877141PINAG48V, I50V, I54S, V82AL33F, K43TQ7E, L10IV, I13IV, G16A, E34Q, R41K, L63T, A71V, V77I, I93LB
 12-31503150-30610DQ877160PINAM46L, G48V, I54S, V82AL33F, K43T, T74TPL10I, I13V, K14R, L19Q, R41RK, L63T, A71V, V77I, I93LB
 12-30573057-30407DQ877163PINAG48V, I54S, V82A, L90ML33F, K43TL10I, K20R, E34N, E35D, M36I, N37S, R57K, D60DE, I62V, L63P, K70KAET, A71V, I93LB
 12-30133013-30402DQ877183PINAG48V, I54S, V82AQ58EL10I, I15V, K20R, E35D, M36I, D60E, I62V, L63P, A71V, P79A, I93LB
 12-30513051-30512DQ877243PINAM46L, G48V, I54S, V82AL24I, L33F, Q58EL10I, I13V, D60E, L63P, V77I, L89LMB
 12-31963196-30617DQ877245PINAM46L, G48V, I50V, I54S, V82AL33FL10V, L19LI, E34Q, R41K, I62V, L63P, A71V, T74S, V77I, I93LB
 48-11371137-30729DQ877276PINAG48V, I54S, V82A, L90ML33FL10I, T12V, I13V, E34Q, N37DE, I62V, L63PS, A71I, V77I, I93LB
 48-10691069-30623DQ877329PINAG48V, I54S, V82AL33F, K43TQ7R, L10I, K20R, E35D, M36I, N37D, I62V, L63P, I64V, A71V, I85V, I93LB
 48-18311831-30924DQ877468PINAG48V, I54S, L76LV, V82A L10I, K14R, I15V, I62IV, L63P, A71V, V77VI, I93LB
 48-20212021-30507DQ877851PINAM46I, G48LV, I54S, V82AL33F, Q58EL10I, I62V, L63P, A71V, V77I, I93LB
 48-26162616-30806DQ877906PINAG48V, I50V, I54S, V82A, L90ML33FL10IV, I13V, E34Q, I62V, L63P, I64L, I66IV, H69R, A71L, I72V, V77I, I93MB
 48-30063006-30226DQ877916PINAM46L, G48V, I54S, V82A, I84VL33FL10I, R41K, D60E, I62V, L63P, A71L, V77I, T91TAGS, I93LB
 48-30273027-30304DQ877938PINAM46L, G48V, I54S, V82AL33F, Q58EL10I, T12I, I13IV, G16E, I62V, L63H, A71V, V77I, I93LB
 48-30813081-30311DQ877990PINAM46L, G48V, I54S, V82A, L90ML33F, Q58EL10IV, I13V, E34Q, R41RK, I62V, L63PS, K70T, A71V, V77VI, I93LB
 48-30843084-30520DQ877993PINAM46L, G48V, I54S, V82AL33F, F53LL10IV, I13V, G16E, N37D, I62V, L63T, A71I, V77I, I93LB
 48-31433143-30430DQ878054PINAM46I, G48V, I54S, V82C, L90M T4TS, L10V, R41K, I62V, L63A, I64V, A71V, I72V, V77I, I93LB
 48-31543154-30423DQ878065PINAM46MI, G48V, I54S, V82A, L90MK43TL10I, E34Q, Q61E, I62V, L63P, A71V, I72IV, V77I, I93LB
 48-31573157-30424DQ878066PINAM46L, G48V, I54S, V82A, L90ML33FL10I, I13V, I62V, L63P, A71V, I72V, T74S, V77I, I93LB
 48-32063206-30512DQ878116PINAM46L, G48V, I54S, V82A, L90ML33LFL10I, G16A, K20R, M36I, N37D, I62V, L63P, A71V, I72V, I93LB
 48-32353235-30521DQ878142PINAM46I, G48V, I54S, V82AG73STL10I, N37D, F53Y, I62V, L63P, A71V, V77I, I93LB
 48-32403240-30603DQ878147PINAM46L, G48V, I54S, V82A L10I, L63P, A71V, V77I, I93LB
 48-32553255-30625DQ878159PINAI54S, V82M, L90ML33FL10V, I13V, I15V, K20R, E34EV, E35D, M36I, N37S, R41K, K55N, L63PT, A71V, V77VI, L89I, I93LB
 48-32603260-30630DQ878164PINAG48V, I50V, I54S, V82A L10I, I15V, L19I, K20R, E35D, M36I, N37DE, I64IV, A71V, I93MB
 48-40344034-30218DQ878268PINAM46I, I54S, V82A, L90ML10F, L33FT12P, I13V, I62IV, L63P, A71V, I72V, Q92K, I93L, C95FB
 48-40674067-30402DQ878297PINAM46I, G48V, I54S, V82A L10I, I62V, L63P, A71V, V77I, I93LB
 48-40914091-30331DQ878321PINAG48L, I50V, I54S, V82A L10I, K14R, E34K, I62V, L63P, H69HY, A71L, I72IV, V77I, I93LB
 48-41254125-30319DQ878356PINAG48V, I54S, V82AL33FL10I, I15IV, G16E, K20KR, M36MI, I62V, L63H, A71IV, T91TS, I93LB
 48-41524152-30327DQ878384PINAG48M, I50V, I54S, V82A, L90MQ58EL10I, K20R, E34R, E35D, M36I, N37S, R41K, D60DE, I62V, L63P, A71V, V77I, I93LB
  4152-30626DQ878386PI, RTV, TPV>13G48M, I50IV, I54S, V82AT, L90MQ58EL10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93LB
  4152-40205DQ878385PI, RTV, TPV>45G48M, I54S, V82AT, I84V, L90MQ58QEL10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93LB
 48-42204220-30423DQ878454PINAM46I, G48V, I50V, I54S, V82A L10I, E34Q, F53Y, I62V, L63Q, A71V, I72V, T74S, V77I, I93LB
  4220-40504DQ878455PI, RTV, TPV>54M46L, G48M, I54S, V82T, I84VL33FL10I, I13V, F53Y, I62V, L63P, A71F, I72V, T74S, V77VI, P79PHSY, I93LB
 48-60206020-30328DQ878619PINAG48V, I50IV, I54S, V82AL33FL10IV, I13V, G16E, K20KT, D60E, L63S, A71V, V77I, I93LB
 48-60336033-30423DQ878632PINAM46L, G48V, I54S, V82A L10I, K20R, M36I, N37D, I62V, L63PQ, A71V, I93LB
 48-60616061-30723DQ878659PINAM46L, G48V, I50V, I54S, V82A L10I, E34Q, N37S, F53Y, I62V, L63P, I64V, A71V, I72V, T74S, V77I, I85V, I93LB
 48-61586158-30704DQ878734PINAG48V, I50V, I54S, V82AL33F, Q58EQ7QE, L10I, G16A, L19I, E34Q, L63T, A71V, I72T, T74S, V77I, I93LB
 48-61626162-30903DQ878738PINAG48V, I54S, V82A, L90ML33LFL10IV, K20R, E34Q, E35D, M36I, N37DE, D60DE, I62IV, L63P, H69K, A71V, T91S, I93L, C95FB
 48-62016201-30729DQ878773PINAM46I, G48V, I50V, I54S, V82A L10I, E34Q, L63P, H69Y, A71I, V77I, I93LB
 48-62126212-30904DQ878785PINAM46I, G48V, I54S, V82A, I84IV, L90LML33F, K43T, T74PL10I, I13V, K20R, E34Q, M36I, I62V, L63P, H69K, A71V, I93MB
 48-62296229-30808DQ878796PINAG48M, I54S, V82A L10I, I13V, K20I, M36I, R41K, A71VB
 48-62866286-30820DQ878834PINAG48V, I54S, V82A, I84VL33I, Q58EL10I, I13V, Q18H, K20M, M36I, I62V, L63P, I64V, T74SB
 48-63106310-30911DQ878848PINAM46I, I54S, V82A, L90ML33F, K43TL10V, I13V, L19I, E35D, M36I, K55R, L63P, A71V, T74S, I93LB
 48-63416341-30918DQ878864PINAM46MI, G48M, I54S, V82A, L90M L10IV, K20R, M36I, N37D, Q61QHKN, I62V, L63T, I64V, H69K, A71V, T74S, I93LB
 48-70217021-30825DQ878905PINAG48M, I54S, V82SL24I, L33F, Q58EL10I, G16A, E34Q, E35D, M36I, N37D, R57RK, I62V, L63P, A71V, I72IV, Q92KB
 48-70887088-30627DQ878942PINAM46L, G48V, I54S, V82AL33F, K43TL10V, I13V, N37S, I62V, L63Q, I64V, I72V, T74A, V77IB
 48-71677167-30613DQ879004PINAM46L, G48M, I54S, V82A, L90ML33FL10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I72V, I93LB
 48-92709270-30918DQ877520PINAM46L, G48V, I54S, V82A, L90MK43TL10I, I13V, I15V, Q18H, K20I, M36I, N37D, I62V, L63P, A71L, I93LB
 48-91729172-30904DQ877557PINAM46I, G48Q, I54S, V82F, L90MK43T, F53LL10I, K20R, E35D, M36IV, N37S, R41RK, D60E, Q61E, I62V, L63P, H69HY, A71V, I72V, V77I, I93LB
 48-91039103-30908DQ877692PINAG48V, I54S, V82AL33FL10I, I13V, E35D, M36MIL, N37D, I62V, I64V, T74A, I93LB
 48-80138013-30811DQ879058PINAM46I, G48V, I54S, V82A, I84VK43TL10I, E34Q, I62V, L63T, I64V, E65D, I72V, T74S, V77I, I85V, T91AB
 48-80498049-30819DQ879076PINAM46I, G48V, I50V, I54S, V82AL33FL10I, I13V, E34Q, R41K, I62V, L63P, A71V, I72V, T74A, V77I, I93LB
Dau (2010)06467A06467AGU581750PINAM46I, G48M, I54S, V82A, L90ML33FL10I, L19LI, E34Q, I62V, L63P, I64M, A71V, V77I, I93LB
Rhee (2010)CA634CA63963GQ211835SQV, IDV, RTV, Unknown, APV, LPV>355M46I, G48V, I50V, I54S, V82AL33F, K43TL10I, K20R, E34T, E35D, M36I, N37D, I62V, L63P, A71IV, I72V, V77I, I85V, I93LB
 CA8346CA84185GQ213086SQV, IDV, RTV, Unknown>360G48V, I54S, V82AL33F, Q58QEL10I, D60E, L63P, A71V, V77I, T91AB
  CA123387GQ213746SQV, IDV, RTV, Unknown>360G48V, I54S, V82AL33F, Q58EL10I, I13IV, D60E, L63P, A71V, V77I, T91AB
Aulicino (2011)ARL908RABARL908RABFJ525820PINAI47V, G48V, I54S, V82SL33F, F53FL, Q58EL10I, I13V, G16E, K20R, E35D, M36I, R41K, R57K, Q61N, L63T, E65D, H69Y, A71V, I72T, L89M, I93LB