Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	B
Gene	PR
Mutation	I54S
Rx	>= 1 PI
IncludeMixtures	No

References	10
Patients	82
Isolates	97

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Balotta (2000)	CB-199	CB-199	AF252052	SQV, NFV, IDV		G48V, I54S, V82A		L10I, L63P, A71V, V77I, I93L, C95CW	B
Gonzales (2001)	CA1469	CA3917	AY030604	SQV, IDV, NFV	119	G48V, I54S, V82A	M46V	L10I, G16GA, N37D, L63P, A71I, V77I, I93L	B
	CA5478	CA13553	AY032017	PI	NA	G48V, I54S, V82A		L10I, I15V, L63Q, I64V, A71V, I93L	B
Romano (2002)	MZ-pt17	pt17-t1	AF493392	SQV, RTV, NFV, LPV		G48V, I54S, V82A, L90M		T4S, L10I, L19V, K20R, M36I, N37D, I62V, L63P, I64V, H69I	B
Holguin (2003)	SP_LP12	SP_LP12	AF455610	PI	NA	I54S	F53L	V56L, L63P, H69Q	B
Wu (2003)	CA1469	CA9609	AF544484	SQV, IDV, NFV, RTV	164	G48V, I54S, V82A	M46V	L10I, G16A, N37D, L63P, A71I, V77I, I93L	B
Mo (2005)	9124	9124_d1		PI	NA	G48V, I54S, V82A		L10I, E34Q, I62V, L63P, A71V, T74S, V77I, I93L	B
		9124_d59		PI, LPV	NA	G48V, I54S, V82A		L10I, E34Q, I62V, L63P, A71V, I72V, T74S, V77I, I93L	B
		9124_d164		PI, LPV	NA	G48V, I54S, V82A		L10I, E34Q, I62V, L63P, A71V, I72V, T74S, V77I, I93L	B
		9124_d339		PI, LPV	NA	M46MIV, G48V, I50V, I54S, V82A	L33LF	L10I, E34Q, I62V, L63P, A71V, I72V, T74S, V77I, I93L	B
Rhee (2005)	CA634	CA38020	AY796450	SQV, IDV, RTV, Unknown, APV, LPV	>355	M46I, G48V, I50V, I54S, V82A	L33F, K43T	L10I, K20R, E34T, E35D, M36I, N37D, I62V, L63P, A71V, I72V, V77I, I85V, I93L	B
		CA38022	AY796451	SQV, IDV, RTV, Unknown, APV, LPV	>355	M46I, G48V, I50V, I54S, V82A	L33F, K43T	L10I, K20R, E34T, E35D, M36I, N37D, I62V, L63P, A71V, I72V, V77I, I85V, I93L	B
		CA42683	AY796452	SQV, IDV, RTV, Unknown, APV, LPV	>355	M46I, G48V, I50V, I54S, V82A	L33F, K43T	L10I, K20R, E34T, E35D, M36I, N37D, I62V, L63P, A71V, I72V, V77I, I85V, I93L	B
	CA1469	CA11831	AY796712	SQV, IDV, NFV, RTV, APV	189	G48V, I54S, V82A		L10I, G16GA, N37D, L63P, A71I, V77I, I93L	B
		CA20270	AY796713	SQV, IDV, NFV, RTV, APV	248	M46L, G48V, I54S, V82A, I84IV	L33F	L10I, G16A, N37D, D60DE, L63P, A71I, V77I, I93L	B
	SHNY-13	SHNY-13		PI	NA	M46L, G48M, I54S, V82A	L33F	L10I, I13IV, L63P, A71V, I93L	B
Baxter (2006)	12-3088	3088-30501	DQ876101	PI	NA	M46I, G48V, I50V, I54S, V82ACGS, L90LM		L10I, E34Q, Q61H, L63P, I64V, A71V, V77I, I93L	B
	12-4046	4046-30514	DQ876151	PI	NA	G48V, I54S, V82A, L90M	L33F	L10I, I13V, K20R, E35D, M36I, R41K, I62V, L63P, A71I, I72M, I93L	B
	12-4002	4002-30124	DQ876158	PI	NA	G48MV, I54S, V82A, L90M	L33F, K43T	L10V, I13V, Q18QH, K20R, L24LF, E35D, M36I, N37D, I62V, L63P, A71I, I93L	B
	12-4013	4013-30203	DQ876169	PI	NA	M46I, G48V, I50V, I54S, V82A	L33F, L89V	L10V, I13V, Q18QH, K20R, E35D, M36L, N37D, L63P, A71V, I72M, I93L	B
		4013-30815	DQ879136	PI, RTV, TPV	>28	M46I, G48V, I54S, V82T, I84V	L33F, L89V	L10V, I13V, Q18H, K20R, E35D, M36L, N37D, L63P, A71V, I72M, I93L	B
	12-1016	1016-30428	DQ876233	PI	NA	M46L, G48M, I54S, V82A, L90LM	L33F	L10I, G16A, L19LV, E34Q, N37D, Q61K, I62V, L63P, A71I, T74S, V77I, Q92S, I93L	B
	12-1025	1025-30321	DQ876284	PI	NA	G48V, I54S, V82S	K43T	L10I, I15V, G16A, K20T, L38LF, R41K, L63P, I64V, A71V, T74S, V77I, I85V, I93L	B
	12-1804	1804-30528	DQ876295	PI	NA	M46L, G48V, I54S, V82A	L33F, Q58QE, G73S, L89V	L10I, V11VL, G16A, I62V, L63P, I64IL, A71V, T74S, I93L	B
	12-2371	2371-30730	DQ876343	PI	NA	G48V, I54S, V82A, L90M	L33F, Q58E	L5F, L10I, I13V, E34Q, N37NS, D60E, I62V, L63P, H69R, A71L, V77I, I93L	B
	12-1832	1832-30623	DQ876390	PI	NA	M46I, G48V, I54S, V82A	L33F, G73S	L10I, I13V, I15V, L63P, A71V, I72M, V77VI, I93L	B
	12-1339	1339-30416	DQ876443	PI	NA	G48V, I54S, V82A, I84V	L33F, Q58E	L10I, I13V, L63P, A71V, I93L	B
	12-1100	1100-30305	DQ876513	PI	NA	M46L, G48V, I54S, V82A	L33F	L10I, I13V, R41K, K43I, I62V, L63P, H69Y, A71V, I72IT, V77I, I93L	B
	12-1875	1875-30528	DQ876534	PI	NA	M46*L, G48V, I54S, V82A		L10I, K14KR, N37D, L63P, K70KE, A71V, V77I, I93L	B
	12-1108	1108-30624	DQ876559	PI	NA	G48V, I54S, V82A	L24I	L10I, I62V, L63P, H69R, A71V, I72V, V77I	B
	12-2423	2423-30820	DQ876748	PI	NA	G48V, I50V, I54S, V82A	L33F	L10V, I13V, E34Q, L63P, A71V, I72V, V77I, I93L	B
	12-1117	1117-30310	DQ876773	PI	NA	G48M, I54S, V82F	L33F, Q58E	L10V, I13V, K20Q, M36I, I62V, L63P, A71V, V77I, I93L	B
	12-1466	1466-30606	DQ876863	PI	NA	M46I, G48M, I50V, I54S, V82A, L90M	K43T	L10IV, E34Q, F53Y, I62V, L63P, I64V, A71V, I72V, V77I, I85V, I93L	B
		1466-31229	DQ879107	PI, RTV, TPV	>29	M46I, I54S, V82T, L90M	K43T	L10I, E34Q, I62V, L63P, I64V, A71V, I72V, V77I, I85V, I93L	B
	12-1946	1946-30528	DQ876911	PI	NA	M46I, I54S, V82A, I84V, L90M	L33F	L10I, I13V, E34Q, N37D, L63P, I66F, A71V, Q92K	B
	12-2056	2056-30616	DQ876920	PI	NA	M46I, G48V, I54S, V82A	L33LF	L10IV, R41K, L63A, A71V, V77I, T91A	B
	12-1633	1633-30313	DQ876967	PI	NA	M46I, G48V, I54S, V82C, L90M	L33LF	L10I, R41K, L63GS, A71V, V77I, I93L	B
	12-1640	1640-30320	DQ876971	PI	NA	M46L, G48M, I54S, V82A	L24I, L33F, K43T	L10I, I13V, L19LI, M36L, F53Y, K55KR, I62V, L63V, I64V, T74A	B
	12-1536	1536-30611	DQ877001	PI	NA	G48V, I54S, V82A	L33F, K43KT	L10I, I13V, R41K, K45KQ, I64V, T74S, V77I, I93L	B
	12-1984	1984-30602	DQ877030	PI	NA	M46L, G48V, I54S, V82A	L24I, L33F	L10I, I13V, I62V, L63P, I64L, A71V, I72V, T74E, V77I, I93L	B
	12-1559	1559-30603	DQ877060	PI	NA	G48M, I54S, V82A	L33LF, Q58QE	L10I, L19T, K20R, M36I, I62IV, L63Q, I64V, A71V, T91A	B
	12-1726	1726-30502	DQ877094	PI	NA	M46L, G48V, I54S, V82A, L90M	L33F, Q58E	L10I, I13V, G16E, I62V, L63T, A71V, V77I, I93L	B
	12-1738	1738-30617	DQ877141	PI	NA	G48V, I50V, I54S, V82A	L33F, K43T	Q7E, L10IV, I13IV, G16A, E34Q, R41K, L63T, A71V, V77I, I93L	B
	12-3150	3150-30610	DQ877160	PI	NA	M46L, G48V, I54S, V82A	L33F, K43T, T74TP	L10I, I13V, K14R, L19Q, R41RK, L63T, A71V, V77I, I93L	B
	12-3057	3057-30407	DQ877163	PI	NA	G48V, I54S, V82A, L90M	L33F, K43T	L10I, K20R, E34N, E35D, M36I, N37S, R57K, D60DE, I62V, L63P, K70KAET, A71V, I93L	B
	12-3013	3013-30402	DQ877183	PI	NA	G48V, I54S, V82A	Q58E	L10I, I15V, K20R, E35D, M36I, D60E, I62V, L63P, A71V, P79A, I93L	B
	12-3051	3051-30512	DQ877243	PI	NA	M46L, G48V, I54S, V82A	L24I, L33F, Q58E	L10I, I13V, D60E, L63P, V77I, L89LM	B
	12-3196	3196-30617	DQ877245	PI	NA	M46L, G48V, I50V, I54S, V82A	L33F	L10V, L19LI, E34Q, R41K, I62V, L63P, A71V, T74S, V77I, I93L	B
	48-1137	1137-30729	DQ877276	PI	NA	G48V, I54S, V82A, L90M	L33F	L10I, T12V, I13V, E34Q, N37DE, I62V, L63PS, A71I, V77I, I93L	B
	48-1069	1069-30623	DQ877329	PI	NA	G48V, I54S, V82A	L33F, K43T	Q7R, L10I, K20R, E35D, M36I, N37D, I62V, L63P, I64V, A71V, I85V, I93L	B
	48-1831	1831-30924	DQ877468	PI	NA	G48V, I54S, L76LV, V82A		L10I, K14R, I15V, I62IV, L63P, A71V, V77VI, I93L	B
	48-2021	2021-30507	DQ877851	PI	NA	M46I, G48LV, I54S, V82A	L33F, Q58E	L10I, I62V, L63P, A71V, V77I, I93L	B
	48-2616	2616-30806	DQ877906	PI	NA	G48V, I50V, I54S, V82A, L90M	L33F	L10IV, I13V, E34Q, I62V, L63P, I64L, I66IV, H69R, A71L, I72V, V77I, I93M	B
	48-3006	3006-30226	DQ877916	PI	NA	M46L, G48V, I54S, V82A, I84V	L33F	L10I, R41K, D60E, I62V, L63P, A71L, V77I, T91TAGS, I93L	B
	48-3027	3027-30304	DQ877938	PI	NA	M46L, G48V, I54S, V82A	L33F, Q58E	L10I, T12I, I13IV, G16E, I62V, L63H, A71V, V77I, I93L	B
	48-3081	3081-30311	DQ877990	PI	NA	M46L, G48V, I54S, V82A, L90M	L33F, Q58E	L10IV, I13V, E34Q, R41RK, I62V, L63PS, K70T, A71V, V77VI, I93L	B
	48-3084	3084-30520	DQ877993	PI	NA	M46L, G48V, I54S, V82A	L33F, F53L	L10IV, I13V, G16E, N37D, I62V, L63T, A71I, V77I, I93L	B
	48-3143	3143-30430	DQ878054	PI	NA	M46I, G48V, I54S, V82C, L90M		T4TS, L10V, R41K, I62V, L63A, I64V, A71V, I72V, V77I, I93L	B
	48-3154	3154-30423	DQ878065	PI	NA	M46MI, G48V, I54S, V82A, L90M	K43T	L10I, E34Q, Q61E, I62V, L63P, A71V, I72IV, V77I, I93L	B
	48-3157	3157-30424	DQ878066	PI	NA	M46L, G48V, I54S, V82A, L90M	L33F	L10I, I13V, I62V, L63P, A71V, I72V, T74S, V77I, I93L	B
	48-3206	3206-30512	DQ878116	PI	NA	M46L, G48V, I54S, V82A, L90M	L33LF	L10I, G16A, K20R, M36I, N37D, I62V, L63P, A71V, I72V, I93L	B
	48-3235	3235-30521	DQ878142	PI	NA	M46I, G48V, I54S, V82A	G73ST	L10I, N37D, F53Y, I62V, L63P, A71V, V77I, I93L	B
	48-3240	3240-30603	DQ878147	PI	NA	M46L, G48V, I54S, V82A		L10I, L63P, A71V, V77I, I93L	B
	48-3255	3255-30625	DQ878159	PI	NA	I54S, V82M, L90M	L33F	L10V, I13V, I15V, K20R, E34EV, E35D, M36I, N37S, R41K, K55N, L63PT, A71V, V77VI, L89I, I93L	B
	48-3260	3260-30630	DQ878164	PI	NA	G48V, I50V, I54S, V82A		L10I, I15V, L19I, K20R, E35D, M36I, N37DE, I64IV, A71V, I93M	B
	48-4034	4034-30218	DQ878268	PI	NA	M46I, I54S, V82A, L90M	L10F, L33F	T12P, I13V, I62IV, L63P, A71V, I72V, Q92K, I93L, C95F	B
	48-4067	4067-30402	DQ878297	PI	NA	M46I, G48V, I54S, V82A		L10I, I62V, L63P, A71V, V77I, I93L	B
	48-4091	4091-30331	DQ878321	PI	NA	G48L, I50V, I54S, V82A		L10I, K14R, E34K, I62V, L63P, H69HY, A71L, I72IV, V77I, I93L	B
	48-4125	4125-30319	DQ878356	PI	NA	G48V, I54S, V82A	L33F	L10I, I15IV, G16E, K20KR, M36MI, I62V, L63H, A71IV, T91TS, I93L	B
	48-4152	4152-30327	DQ878384	PI	NA	G48M, I50V, I54S, V82A, L90M	Q58E	L10I, K20R, E34R, E35D, M36I, N37S, R41K, D60DE, I62V, L63P, A71V, V77I, I93L	B
		4152-30626	DQ878386	PI, RTV, TPV	>13	G48M, I50IV, I54S, V82AT, L90M	Q58E	L10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93L	B
		4152-40205	DQ878385	PI, RTV, TPV	>45	G48M, I54S, V82AT, I84V, L90M	Q58QE	L10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93L	B
	48-4220	4220-30423	DQ878454	PI	NA	M46I, G48V, I50V, I54S, V82A		L10I, E34Q, F53Y, I62V, L63Q, A71V, I72V, T74S, V77I, I93L	B
		4220-40504	DQ878455	PI, RTV, TPV	>54	M46L, G48M, I54S, V82T, I84V	L33F	L10I, I13V, F53Y, I62V, L63P, A71F, I72V, T74S, V77VI, P79PHSY, I93L	B
	48-6020	6020-30328	DQ878619	PI	NA	G48V, I50IV, I54S, V82A	L33F	L10IV, I13V, G16E, K20KT, D60E, L63S, A71V, V77I, I93L	B
	48-6033	6033-30423	DQ878632	PI	NA	M46L, G48V, I54S, V82A		L10I, K20R, M36I, N37D, I62V, L63PQ, A71V, I93L	B
	48-6061	6061-30723	DQ878659	PI	NA	M46L, G48V, I50V, I54S, V82A		L10I, E34Q, N37S, F53Y, I62V, L63P, I64V, A71V, I72V, T74S, V77I, I85V, I93L	B
	48-6158	6158-30704	DQ878734	PI	NA	G48V, I50V, I54S, V82A	L33F, Q58E	Q7QE, L10I, G16A, L19I, E34Q, L63T, A71V, I72T, T74S, V77I, I93L	B
	48-6162	6162-30903	DQ878738	PI	NA	G48V, I54S, V82A, L90M	L33LF	L10IV, K20R, E34Q, E35D, M36I, N37DE, D60DE, I62IV, L63P, H69K, A71V, T91S, I93L, C95F	B
	48-6201	6201-30729	DQ878773	PI	NA	M46I, G48V, I50V, I54S, V82A		L10I, E34Q, L63P, H69Y, A71I, V77I, I93L	B
	48-6212	6212-30904	DQ878785	PI	NA	M46I, G48V, I54S, V82A, I84IV, L90LM	L33F, K43T, T74P	L10I, I13V, K20R, E34Q, M36I, I62V, L63P, H69K, A71V, I93M	B
	48-6229	6229-30808	DQ878796	PI	NA	G48M, I54S, V82A		L10I, I13V, K20I, M36I, R41K, A71V	B
	48-6286	6286-30820	DQ878834	PI	NA	G48V, I54S, V82A, I84V	L33I, Q58E	L10I, I13V, Q18H, K20M, M36I, I62V, L63P, I64V, T74S	B
	48-6310	6310-30911	DQ878848	PI	NA	M46I, I54S, V82A, L90M	L33F, K43T	L10V, I13V, L19I, E35D, M36I, K55R, L63P, A71V, T74S, I93L	B
	48-6341	6341-30918	DQ878864	PI	NA	M46MI, G48M, I54S, V82A, L90M		L10IV, K20R, M36I, N37D, Q61QHKN, I62V, L63T, I64V, H69K, A71V, T74S, I93L	B
	48-7021	7021-30825	DQ878905	PI	NA	G48M, I54S, V82S	L24I, L33F, Q58E	L10I, G16A, E34Q, E35D, M36I, N37D, R57RK, I62V, L63P, A71V, I72IV, Q92K	B
	48-7088	7088-30627	DQ878942	PI	NA	M46L, G48V, I54S, V82A	L33F, K43T	L10V, I13V, N37S, I62V, L63Q, I64V, I72V, T74A, V77I	B
	48-7167	7167-30613	DQ879004	PI	NA	M46L, G48M, I54S, V82A, L90M	L33F	L10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I72V, I93L	B
	48-9270	9270-30918	DQ877520	PI	NA	M46L, G48V, I54S, V82A, L90M	K43T	L10I, I13V, I15V, Q18H, K20I, M36I, N37D, I62V, L63P, A71L, I93L	B
	48-9172	9172-30904	DQ877557	PI	NA	M46I, G48Q, I54S, V82F, L90M	K43T, F53L	L10I, K20R, E35D, M36IV, N37S, R41RK, D60E, Q61E, I62V, L63P, H69HY, A71V, I72V, V77I, I93L	B
	48-9103	9103-30908	DQ877692	PI	NA	G48V, I54S, V82A	L33F	L10I, I13V, E35D, M36MIL, N37D, I62V, I64V, T74A, I93L	B
	48-8013	8013-30811	DQ879058	PI	NA	M46I, G48V, I54S, V82A, I84V	K43T	L10I, E34Q, I62V, L63T, I64V, E65D, I72V, T74S, V77I, I85V, T91A	B
	48-8049	8049-30819	DQ879076	PI	NA	M46I, G48V, I50V, I54S, V82A	L33F	L10I, I13V, E34Q, R41K, I62V, L63P, A71V, I72V, T74A, V77I, I93L	B
Dau (2010)	06467A	06467A	GU581750	PI	NA	M46I, G48M, I54S, V82A, L90M	L33F	L10I, L19LI, E34Q, I62V, L63P, I64M, A71V, V77I, I93L	B
Rhee (2010)	CA634	CA63963	GQ211835	SQV, IDV, RTV, Unknown, APV, LPV	>355	M46I, G48V, I50V, I54S, V82A	L33F, K43T	L10I, K20R, E34T, E35D, M36I, N37D, I62V, L63P, A71IV, I72V, V77I, I85V, I93L	B
	CA8346	CA84185	GQ213086	SQV, IDV, RTV, Unknown	>360	G48V, I54S, V82A	L33F, Q58QE	L10I, D60E, L63P, A71V, V77I, T91A	B
		CA123387	GQ213746	SQV, IDV, RTV, Unknown	>360	G48V, I54S, V82A	L33F, Q58E	L10I, I13IV, D60E, L63P, A71V, V77I, T91A	B

Protease Inhibitors

Database

Resources

Team