Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	G48M
Rx	>= 1 PI
IncludeMixtures	No

References	10
Patients	56
Isolates	62

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Balotta (2000)	CB-223	CB-223	AF252078	SQV, IDV		M46I, G48M, V82A, L90M		L10I, N37H, R41K, R57K, L63S, H69K, A71T, I93L	B
Gonzales (2001)	CA5067	CA12630	AY031636	Unknown, PI	NA	G48M, I54V, V82A, L90M	F53L	L10I, R41K, L63P, A71T, I72V	B
Garcia-Bujalance (2005)	GBS_42	GBS_42	AY872323	RTV, NFV, SQV, LPV		I47V, G48M, I54L, V82A, I84V, L90M	L33F, F53L	P9S, L10R, K14N, I15K, E34Q, N37D, L63P, A71V, V77I, I93L	B
Rhee (2005)	CA1141	CA39291	AY796514	IDV, SQV, RTV	276	G48M, I50V, I54V, V82T	G73C	L10I, I15V, K20R, M36I, N37D, I62V, L63P, A71AITV, I72E, I85V	B
		CA39293	AY796515	IDV, SQV, RTV, LPV	333	G48M, I50V, I54V, V82T	G73C	L10I, I15V, K20R, M36I, N37D, K55KR, I62V, L63P, A71AITV, I72E, I85V	B
	CA1165	CA33431	AY796542	SQV, NFV, IDV, RTV, Unknown, APV, LPV	>282	G48M, I54V, V82A	F53FL	L10I, T12P, K14R, E35D, M36MI, N37D, L63P, C67D, A71AT	B
		CA42621	AY796543	SQV, NFV, IDV, RTV, Unknown, APV, LPV	>347	I47IV, G48M, I54V, V82AS	K43T, F53FL	L10I, T12P, K14R, K20KR, E35D, M36I, N37D, L63P, C67D, A71AT	B
	CA1833	CA33923	AY796829	IDV, NFV, SQV, RTV, APV	330	M46L, G48M, I54M, V82A, I84V	L33F	L10I, T12P, L19V, L23LV, L63T, A71V, I72T, T74A, I93L	B
	CA5177	CA38076	AY798433	IDV, NFV, SQV, RTV, LPV, APV	251	G48M, I54V, V82A, L90M	L33F, K43T, F53L, G73S	Q7R, L10V, I15V, K20T, E35D, M36I, R57RK, I62V, L63P, I66F, H69HR, A71V, I72L	B
	SHNY-13	SHNY-13		PI	NA	M46L, G48M, I54S, V82A	L33F	L10I, I13IV, L63P, A71V, I93L	B
Baxter (2006)	12-4049	4049-30724	DQ876155	PI	NA	G48M, I54A, V82T	L24I, F53L	L10I, K14R, N37ND, I62V, L63E, I64V, E65D, A71T, I72V, T74S, V77I, I93L	B
	12-1769	1769-30430	DQ876202	PI	NA	G48M, I54A, V82A, L90M	L33F, K43KT	L10I, E35ED, M36L, N37D, R57RK, I62V, L63P, A71I, I72V, Q92QK, I93L	B
	12-1016	1016-30428	DQ876233	PI	NA	M46L, G48M, I54S, V82A, L90LM	L33F	L10I, G16A, L19LV, E34Q, N37D, Q61K, I62V, L63P, A71I, T74S, V77I, Q92S, I93L	B
	12-1049	1049-30304	DQ876306	PI	NA	I47V, G48M, I54M, V82A, I84V, L90M	L33F, F53L, L89V	L10I, I13V, L19I, E34Q, N37NS, R57K, L63M, I64IM, I66F, A71V, G73D, Q92K, C95L	B
	12-1503	1503-30619	DQ876625	PI	NA	V32I, M46I, I47V, G48M, I54M, V82A	L33F, F53L	L10V, K14R, G16E, K20R, E35D, M36I, K43I, K55R, R57K, I62V, L63S, A71V, I72V	B
	12-2133	2133-30820	DQ876743	PI	NA	G48M, I50V, I54V, V82A, L90M	L33F, F53L	L10I, I13M, L19I, E34Q, I62V, L63H, I64M, H69Q, A71V, V77I, T91S, I93L, C95F	B
	12-1117	1117-30310	DQ876773	PI	NA	G48M, I54S, V82F	L33F, Q58E	L10V, I13V, K20Q, M36I, I62V, L63P, A71V, V77I, I93L	B
	12-1466	1466-30606	DQ876863	PI	NA	M46I, G48M, I50V, I54S, V82A, L90M	K43T	L10IV, E34Q, F53Y, I62V, L63P, I64V, A71V, I72V, V77I, I85V, I93L	B
	12-1640	1640-30320	DQ876971	PI	NA	M46L, G48M, I54S, V82A	L24I, L33F, K43T	L10I, I13V, L19LI, M36L, F53Y, K55KR, I62V, L63V, I64V, T74A	B
	12-1231	1231-30310	DQ877014	PI	NA	I47V, G48M, I54M, V82A, L90M	L33F, F53L	L10I, E34Q, N37NS, L63P, A71V, I72IT, I93L	B
	12-1559	1559-30603	DQ877060	PI	NA	G48M, I54S, V82A	L33LF, Q58QE	L10I, L19T, K20R, M36I, I62IV, L63Q, I64V, A71V, T91A	B
	12-1565	1565-30225	DQ877065	PI	NA	G48M, I54V, L76V, V82A, L90M	F53L	L10I, I15V, K20R, M36I, I62V, L63AP, A71V, I72V, I93L	B
	12-1650	1650-30324	DQ877087	PI	NA	G48M, I54V, V82A	L24I, F53L	L10I, K20KR, M36I, N37D, L63P, A71T	B
	12-1654	1654-30407	DQ877089	PI	NA	G48M, I54V, V82A, L90M	F53L, N88D	L10IV, L19I, K20R, E35D, M36I, N37D, R41K, K55KR, R57K, D60E, I62V, L63S, A71V, I93L, C95F	B
	12-1267	1267-30314	DQ877134	PI	NA	G48M, I50V, I54V, V82A	L33F, K43T, F53L, Q58E	L10I, K20R, E35D, M36I, D60E, I62V, L63P, T74S, I85V, L89M	B
	12-3002	3002-30219	DQ877179	PI	NA	G48M, I54V, V82A, L90M	F53L	L10I, T12Q, I15V, L19P, K20M, E35ED, M36IV, R41K, I62V, L63P, A71I, T74S, I93L	B
	12-3087	3087-30417	DQ877189	PI	NA	G48M, I54V, V82A, L90M	F53L, Q58E, G73S	L10I, T12I, I13V, I15V, K20I, E35D, M36I, N37D, I62V, L63P, A71V, I72IMT	B
	12-3174	3174-30812	DQ877203	PI	NA	G48M, I54V, V82A	L24I, L33F, F53L	L10I, K20T, R41K, L63P, A71V, I93L	B
	48-1258	1258-30610	DQ877784	PI	NA	G48M, I54V, V82A, L90M	F53L	L10I, K20KR, M36MI, I62V, L63P, I64V, H69HY, A71AT, T74S, V77VI, I85V, T91TCS	B
	48-1425	1425-30224	DQ877814	PI	NA	M46L, G48M, I54A, V82A	L24I	L10I, L63P, A71V, I72IT, T74S, V77I, I93L	B
	48-2237	2237-30624	DQ877876	PI	NA	G48M, I54V, V82A, L90M	F53L, G73T	L10I, G17D, K20R, M36I, I62IV, L63P, A71V, I93L	B
	48-3147	3147-30409	DQ878058	PI	NA	M46L, G48M, I54T, V82A, L90M	L33F	L10I, E34Q, R41K, K55R, R57K, I62V, L63P, A71L, I93L	B
	48-3227	3227-30521	DQ878134	PI	NA	V32I, I47V, G48M, I54M, V82A, L90M	L33F, F53L	L10I, I13V, Q18H, L19T, K20KT, M36MI, N37S, L63P, A71V, I93L, C95F	B
	48-3315	3315-30911	DQ878216	PI	NA	G48M, I54V, V82S, L90M	L10F, L33F	E34Q, M36L, N37D, R41K, D60E, I62V, L63P, A71I, I72L, I93L	B
	48-4094	4094-30410	DQ878324	PI	NA	G48M, I54V, V82A, L90M	F53L, G73GS, T74PS	L10V, I15V, K20R, E35D, M36I, Q61E, I62V, L63P, A71V, I93L	B
	48-4152	4152-30327	DQ878384	PI	NA	G48M, I50V, I54S, V82A, L90M	Q58E	L10I, K20R, E34R, E35D, M36I, N37S, R41K, D60DE, I62V, L63P, A71V, V77I, I93L	B
		4152-30626	DQ878386	PI, RTV, TPV	>13	G48M, I50IV, I54S, V82AT, L90M	Q58E	L10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93L	B
		4152-40205	DQ878385	PI, RTV, TPV	>45	G48M, I54S, V82AT, I84V, L90M	Q58QE	L10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93L	B
	48-4199	4199-30507	DQ878431	PI	NA	V32I, I47V, G48M, I54M, V82A, L90M	L33F, M46V	L10V, I13IV, K14T, L19Q, K20R, E35D, M36I, N37D, I62V, L63PS, I64IM, K70KE, A71V, T74E, V77VI, L89IM, I93L	B
	48-4220	4220-40504	DQ878455	PI, RTV, TPV	>54	M46L, G48M, I54S, V82T, I84V	L33F	L10I, I13V, F53Y, I62V, L63P, A71F, I72V, T74S, V77VI, P79PHSY, I93L	B
	48-4302	4302-30806	DQ878520	PI	NA	G48M, I54V, L76V, V82A, I84V	L33F, F53L	L10I, I13V, G16E, K20M, M36V, I62V, L63T, H69R, A71V, T74A, I93L	B
	48-6057	6057-30709	DQ878656	PI	NA	I47V, G48M, I54A, V82A	F53L	L10I, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63P, A71V, I93L	B
	48-6075	6075-30717	DQ878674	PI	NA	G48M, I50V, I54V, V82A, L90M	L33F, F53FL, L89V	T4S, L10I, I13V, L19I, K20T, E35D, M36I, N37D, I62V, L63H, H69Q, A71V, I72V, T74S, I93L, C95F	B
	48-6085	6085-30526	DQ878680	PI	NA	G48M, I54V, V82C, L90M	F53L, G73S	L10I, I13V, I15V, K20T, E34EQ, M36I, N37ND, Q61QE, I62V, L63P, A71V, C95L	B
	48-6181	6181-30721	DQ878753	PI	NA	G48M, I50V, I54A, V82A		L10I, L19I, K20R, M36I, N37D, I62V, L63P, I64M, A71V, I72V, Q92K	B
	48-6229	6229-30808	DQ878796	PI	NA	G48M, I54S, V82A		L10I, I13V, K20I, M36I, R41K, A71V	B
	48-6279	6279-30826	DQ878832	PI	NA	I47V, G48M, I54M, V82A, I84V	V11I, Q58E	L10I, I15V, L19P, K20I, A22V, E34Q, M36I, D60DANT, Q61H, I62V, L63P, A71I, I72T, I85V, I93L	B
	48-6341	6341-30918	DQ878864	PI	NA	M46MI, G48M, I54S, V82A, L90M		L10IV, K20R, M36I, N37D, Q61QHKN, I62V, L63T, I64V, H69K, A71V, T74S, I93L	B
	48-7020	7020-30825	DQ878904	PI	NA	M46L, G48M, I54ST, V82A, I84IV	L24IM, Q58E	L10I, I15V, Q18I, K20RT, E35D, M36I, R41K, D60E, Q61DN, L63P, I64V, A71V, T91TA, Q92QK	B
		7020-31216	DQ878903	PI, RTV, TPV	>16	M46L, G48M, I54T, V82A	L24IM, Q58E	L10I, I15V, Q18I, K20R, E35D, M36I, R41K, D60E, Q61D, L63P, I64V, A71V, T91TA, Q92QK	B
	48-7021	7021-30825	DQ878905	PI	NA	G48M, I54S, V82S	L24I, L33F, Q58E	L10I, G16A, E34Q, E35D, M36I, N37D, R57RK, I62V, L63P, A71V, I72IV, Q92K	B
	48-7167	7167-30613	DQ879004	PI	NA	M46L, G48M, I54S, V82A, L90M	L33F	L10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I72V, I93L	B
	48-7206	7206-30911	DQ879031	PI	NA	G48M, I54V, V82A	L24I	L10I, T12N, L19I, K20KR, M36MI, N37D, L63P, A71T, V77VI, N83S, T91TA	B
Rosen-Zvi (2008)	74	08p74-5		SQV, NFV, LPV	503	G48M, I50V, I54V, V82A, L90M	K43T, F53L, G73S	L10I, I15V, K20R, E35D, M36I, N37D, R57K, Q61QR, I62V, L63P, A71M, I93L	B
Rhee (2009)	CA1524	CA63895	FJ983143	SQV, RTV, APV, LPV	429	G48M, I54V, V82A, I84V	F53L	L10I, V11L, I13V, K14KR, A22V, E35D, M36I, N37D, I62V, L63P, A71V, T74S, T91S, Q92K	B
	CA1833	CA50894	GQ208286	IDV, NFV, SQV, RTV, APV	440	M46L, G48M, I54M, V82A, I84V	V11VI, L33F	L10I, T12P, I13V, K14R, L19V, L63T, A71V, I72T, T74A, P79PS, I93L	B
Dau (2010)	06467A	06467A	GU581750	PI	NA	M46I, G48M, I54S, V82A, L90M	L33F	L10I, L19LI, E34Q, I62V, L63P, I64M, A71V, V77I, I93L	B
Rhee (2010)	CA7849	CA68594	GQ212322	IDV, APV, SQV, LPV	486	I47V, G48M, I54V, V82T, I84V	K43T, F53L	L10I, K20R, E35D, M36I, I62V, L63P, I66F, A71V, Q92R	B
Jones (2012)	175671	175671	JN670367	PI	NA	G48M, I84V	N83D	I13V, E35D, M36I, R57K, I62V, I64V, T74S	B
	176766	176766	JN670411	PI	NA	G48M, I54V, V82A, L90M	F53L	L10I, I15V, M36MI, N37ND, L63P, A71V, I93L	B
	181681	181681	JN670580	PI	NA	M46L, G48M, I54A, V82A, L90M	L33LF, F53L	L10I, T12S, K14R, E34EK, N37E, K55R, I62V, L63P, A71I, I72V, V77I, Q92K, I93L	B
	203414	203414	JN671310	PI	NA	G48M, I50V, I54A, V82A	K43T, F53L, G73S	L10V, I15V, L19P, K20I, E35D, M36I, R41K, R57RK, I62V, L63P, A71V, I85IV, Q92K	B

Protease Inhibitors

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