<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation G48M
Rx >= 1 PI
IncludeMixtures No
References 15
Patients 84
Isolates 90
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Balotta (2000)CB-223CB-223AF252078SQV, IDV M46I, G48M, V82A, L90M L10I, N37H, R41K, R57K, L63S, H69K, A71T, I93LB
Gonzales (2001)CA5067CA12630AY031636Unknown, PINAG48M, I54V, V82A, L90MF53LL10I, R41K, L63P, A71T, I72VB
Ceccherini-Silberstein (2004)1660-842A1660-842AAY855461PINAG48M, V82A, L90MF53LL10I, L19I, K20KR, E35D, M36I, L63P, H69Q, A71VB
Garcia-Bujalance (2005)GBS_42GBS_42AY872323RTV, NFV, SQV, LPV I47V, G48M, I54L, V82A, I84V, L90ML33F, F53LP9S, L10R, K14N, I15K, E34Q, N37D, L63P, A71V, V77I, I93LB
Rhee (2005)CA1141CA39291AY796514IDV, SQV, RTV276G48M, I50V, I54V, V82TG73CL10I, I15V, K20R, M36I, N37D, I62V, L63P, A71AITV, I72E, I85VB
  CA39293AY796515IDV, SQV, RTV, LPV333G48M, I50V, I54V, V82TG73CL10I, I15V, K20R, M36I, N37D, K55KR, I62V, L63P, A71AITV, I72E, I85VB
 CA1165CA33431AY796542SQV, NFV, IDV, RTV, Unknown, APV, LPV>282G48M, I54V, V82AF53FLL10I, T12P, K14R, E35D, M36MI, N37D, L63P, C67D, A71ATB
  CA42621AY796543SQV, NFV, IDV, RTV, Unknown, APV, LPV>347I47IV, G48M, I54V, V82ASK43T, F53FLL10I, T12P, K14R, K20KR, E35D, M36I, N37D, L63P, C67D, A71ATB
 CA1833CA33923AY796829IDV, NFV, SQV, RTV, APV330M46L, G48M, I54M, V82A, I84VL33FL10I, T12P, L19V, L23LV, L63T, A71V, I72T, T74A, I93LB
 CA5177CA38076AY798433IDV, NFV, SQV, RTV, LPV, APV251G48M, I54V, V82A, L90ML33F, K43T, F53L, G73SQ7R, L10V, I15V, K20T, E35D, M36I, R57RK, I62V, L63P, I66F, H69HR, A71V, I72LB
 SHNY-13SHNY-13 PINAM46L, G48M, I54S, V82AL33FL10I, I13IV, L63P, A71V, I93LB
Baxter (2006)12-40494049-30724DQ876155PINAG48M, I54A, V82TL24I, F53LL10I, K14R, N37ND, I62V, L63E, I64V, E65D, A71T, I72V, T74S, V77I, I93LB
 12-17691769-30430DQ876202PINAG48M, I54A, V82A, L90ML33F, K43KTL10I, E35ED, M36L, N37D, R57RK, I62V, L63P, A71I, I72V, Q92QK, I93LB
 12-10161016-30428DQ876233PINAM46L, G48M, I54S, V82A, L90LML33FL10I, G16A, L19LV, E34Q, N37D, Q61K, I62V, L63P, A71I, T74S, V77I, Q92S, I93LB
 12-10491049-30304DQ876306PINAI47V, G48M, I54M, V82A, I84V, L90ML33F, F53L, L89VL10I, I13V, L19I, E34Q, N37NS, R57K, L63M, I64IM, I66F, A71V, G73D, Q92K, C95LB
 12-15031503-30619DQ876625PINAV32I, M46I, I47V, G48M, I54M, V82AL33F, F53LL10V, K14R, G16E, K20R, E35D, M36I, K43I, K55R, R57K, I62V, L63S, A71V, I72VB
 12-21332133-30820DQ876743PINAG48M, I50V, I54V, V82A, L90ML33F, F53LL10I, I13M, L19I, E34Q, I62V, L63H, I64M, H69Q, A71V, V77I, T91S, I93L, C95FB
 12-11171117-30310DQ876773PINAG48M, I54S, V82FL33F, Q58EL10V, I13V, K20Q, M36I, I62V, L63P, A71V, V77I, I93LB
 12-14661466-30606DQ876863PINAM46I, G48M, I50V, I54S, V82A, L90MK43TL10IV, E34Q, F53Y, I62V, L63P, I64V, A71V, I72V, V77I, I85V, I93LB
 12-16401640-30320DQ876971PINAM46L, G48M, I54S, V82AL24I, L33F, K43TL10I, I13V, L19LI, M36L, F53Y, K55KR, I62V, L63V, I64V, T74AB
 12-12311231-30310DQ877014PINAI47V, G48M, I54M, V82A, L90ML33F, F53LL10I, E34Q, N37NS, L63P, A71V, I72IT, I93LB
 12-15591559-30603DQ877060PINAG48M, I54S, V82AL33LF, Q58QEL10I, L19T, K20R, M36I, I62IV, L63Q, I64V, A71V, T91AB
 12-15651565-30225DQ877065PINAG48M, I54V, L76V, V82A, L90MF53LL10I, I15V, K20R, M36I, I62V, L63AP, A71V, I72V, I93LB
 12-16501650-30324DQ877087PINAG48M, I54V, V82AL24I, F53LL10I, K20KR, M36I, N37D, L63P, A71TB
 12-16541654-30407DQ877089PINAG48M, I54V, V82A, L90MF53L, N88DL10IV, L19I, K20R, E35D, M36I, N37D, R41K, K55KR, R57K, D60E, I62V, L63S, A71V, I93L, C95FB
 12-12671267-30314DQ877134PINAG48M, I50V, I54V, V82AL33F, K43T, F53L, Q58EL10I, K20R, E35D, M36I, D60E, I62V, L63P, T74S, I85V, L89MB
 12-30023002-30219DQ877179PINAG48M, I54V, V82A, L90MF53LL10I, T12Q, I15V, L19P, K20M, E35ED, M36IV, R41K, I62V, L63P, A71I, T74S, I93LB
 12-30873087-30417DQ877189PINAG48M, I54V, V82A, L90MF53L, Q58E, G73SL10I, T12I, I13V, I15V, K20I, E35D, M36I, N37D, I62V, L63P, A71V, I72IMTB
 12-31743174-30812DQ877203PINAG48M, I54V, V82AL24I, L33F, F53LL10I, K20T, R41K, L63P, A71V, I93LB
 48-12581258-30610DQ877784PINAG48M, I54V, V82A, L90MF53LL10I, K20KR, M36MI, I62V, L63P, I64V, H69HY, A71AT, T74S, V77VI, I85V, T91TCSB
 48-14251425-30224DQ877814PINAM46L, G48M, I54A, V82AL24IL10I, L63P, A71V, I72IT, T74S, V77I, I93LB
 48-22372237-30624DQ877876PINAG48M, I54V, V82A, L90MF53L, G73TL10I, G17D, K20R, M36I, I62IV, L63P, A71V, I93LB
 48-31473147-30409DQ878058PINAM46L, G48M, I54T, V82A, L90ML33FL10I, E34Q, R41K, K55R, R57K, I62V, L63P, A71L, I93LB
 48-32273227-30521DQ878134PINAV32I, I47V, G48M, I54M, V82A, L90ML33F, F53LL10I, I13V, Q18H, L19T, K20KT, M36MI, N37S, L63P, A71V, I93L, C95FB
 48-33153315-30911DQ878216PINAG48M, I54V, V82S, L90ML10F, L33FE34Q, M36L, N37D, R41K, D60E, I62V, L63P, A71I, I72L, I93LB
 48-40564056-30307DQ878288PINAG48M, I50V, I54V, V82A, L90ML33LF, Q58QEL10I, E34Q, M36MI, K43KE, D60DN, I62V, L63P, C67CW, H69Q, A71V, I93LB
 48-40944094-30410DQ878324PINAG48M, I54V, V82A, L90MF53L, G73GS, T74PSL10V, I15V, K20R, E35D, M36I, Q61E, I62V, L63P, A71V, I93LB
 48-41524152-30327DQ878384PINAG48M, I50V, I54S, V82A, L90MQ58EL10I, K20R, E34R, E35D, M36I, N37S, R41K, D60DE, I62V, L63P, A71V, V77I, I93LB
  4152-30626DQ878386PI, RTV, TPV>13G48M, I50IV, I54S, V82AT, L90MQ58EL10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93LB
  4152-40205DQ878385PI, RTV, TPV>45G48M, I54S, V82AT, I84V, L90MQ58QEL10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93LB
 48-41994199-30507DQ878431PINAV32I, I47V, G48M, I54M, V82A, L90ML33F, M46VL10V, I13IV, K14T, L19Q, K20R, E35D, M36I, N37D, I62V, L63PS, I64IM, K70KE, A71V, T74E, V77VI, L89IM, I93LB
 48-42204220-40504DQ878455PI, RTV, TPV>54M46L, G48M, I54S, V82T, I84VL33FL10I, I13V, F53Y, I62V, L63P, A71F, I72V, T74S, V77VI, P79PHSY, I93LB
 48-43024302-30806DQ878520PINAG48M, I54V, L76V, V82A, I84VL33F, F53LL10I, I13V, G16E, K20M, M36V, I62V, L63T, H69R, A71V, T74A, I93LB
 48-60576057-30709DQ878656PINAI47V, G48M, I54A, V82AF53LL10I, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63P, A71V, I93LB
 48-60756075-30717DQ878674PINAG48M, I50V, I54V, V82A, L90ML33F, F53FL, L89VT4S, L10I, I13V, L19I, K20T, E35D, M36I, N37D, I62V, L63H, H69Q, A71V, I72V, T74S, I93L, C95FB
 48-60856085-30526DQ878680PINAG48M, I54V, V82C, L90MF53L, G73SL10I, I13V, I15V, K20T, E34EQ, M36I, N37ND, Q61QE, I62V, L63P, A71V, C95LB
 48-61816181-30721DQ878753PINAG48M, I50V, I54A, V82A L10I, L19I, K20R, M36I, N37D, I62V, L63P, I64M, A71V, I72V, Q92KB
 48-62296229-30808DQ878796PINAG48M, I54S, V82A L10I, I13V, K20I, M36I, R41K, A71VB
 48-62796279-30826DQ878832PINAI47V, G48M, I54M, V82A, I84VV11I, Q58EL10I, I15V, L19P, K20I, A22V, E34Q, M36I, D60DANT, Q61H, I62V, L63P, A71I, I72T, I85V, I93LB
 48-63416341-30918DQ878864PINAM46MI, G48M, I54S, V82A, L90M L10IV, K20R, M36I, N37D, Q61QHKN, I62V, L63T, I64V, H69K, A71V, T74S, I93LB
 48-70207020-30825DQ878904PINAM46L, G48M, I54ST, V82A, I84IVL24IM, Q58EL10I, I15V, Q18I, K20RT, E35D, M36I, R41K, D60E, Q61DN, L63P, I64V, A71V, T91TA, Q92QKB
  7020-31216DQ878903PI, RTV, TPV>16M46L, G48M, I54T, V82AL24IM, Q58EL10I, I15V, Q18I, K20R, E35D, M36I, R41K, D60E, Q61D, L63P, I64V, A71V, T91TA, Q92QKB
 48-70217021-30825DQ878905PINAG48M, I54S, V82SL24I, L33F, Q58EL10I, G16A, E34Q, E35D, M36I, N37D, R57RK, I62V, L63P, A71V, I72IV, Q92KB
 48-71677167-30613DQ879004PINAM46L, G48M, I54S, V82A, L90ML33FL10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I72V, I93LB
 48-72067206-30911DQ879031PINAG48M, I54V, V82AL24IL10I, T12N, L19I, K20KR, M36MI, N37D, L63P, A71T, V77VI, N83S, T91TAB
Rosen-Zvi (2008)7408p74-5 SQV, NFV, LPV503G48M, I50V, I54V, V82A, L90MK43T, F53L, G73SL10I, I15V, K20R, E35D, M36I, N37D, R57K, Q61QR, I62V, L63P, A71M, I93LB
Waleria-Aleixo (2008)08RJ0409308RJ04093FJ591577PINAM46L, G48M, I54S, V82AL33F, Q58E, N83DL10I, I13V, M36L, R57K, Q61QH, I62V, L63P, I64VB
Rhee (2009)CA1524CA63895FJ983143SQV, RTV, APV, LPV429G48M, I54V, V82A, I84VF53LL10I, V11L, I13V, K14KR, A22V, E35D, M36I, N37D, I62V, L63P, A71V, T74S, T91S, Q92KB
 CA1833CA50894GQ208286IDV, NFV, SQV, RTV, APV440M46L, G48M, I54M, V82A, I84VV11VI, L33FL10I, T12P, I13V, K14R, L19V, L63T, A71V, I72T, T74A, P79PS, I93LB
Charpentier (2010)T063010T063010HQ717823PI, DRV, RTVNAG48M, I50V, I54V, V82C, L90ML33F, Q58EL10V, K14R, K20R, E35D, N37D, D60E, L63P, H69Y, I72V, V77I, T80I, L89IB
Dau (2010)06467A06467AGU581750PINAM46I, G48M, I54S, V82A, L90ML33FL10I, L19LI, E34Q, I62V, L63P, I64M, A71V, V77I, I93LB
Rhee (2010)CA7849CA68594GQ212322IDV, APV, SQV, LPV486I47V, G48M, I54V, V82T, I84VK43T, F53LL10I, K20R, E35D, M36I, I62V, L63P, I66F, A71V, Q92RB
Jones (2012)175671175671JN670367PINAG48M, I84VN83DI13V, E35D, M36I, R57K, I62V, I64V, T74SB
 176766176766JN670411PINAG48M, I54V, V82A, L90MF53LL10I, I15V, M36MI, N37ND, L63P, A71V, I93LB
 181681181681JN670580PINAM46L, G48M, I54A, V82A, L90ML33LF, F53LL10I, T12S, K14R, E34EK, N37E, K55R, I62V, L63P, A71I, I72V, V77I, Q92K, I93LB
 203414203414JN671310PINAG48M, I50V, I54A, V82AK43T, F53L, G73SL10V, I15V, L19P, K20I, E35D, M36I, R41K, R57RK, I62V, L63P, A71V, I85IV, Q92KB
Diaz (2015)RenG15594RenG15594KT746622PINAG48M, I54V, V82SL24I, F53LL10I, K20R, E35D, M36I, N37E, K43PQ, R57K, L63P, H69R, A71V, I72IV, V77VIB
 RenG17214RenG17214KT748242PINAM46L, G48M, I54L, V82A, I84VL33F, K43TL10I, I13V, L23V, E34Q, F53Y, D60E, I62V, L63S, I64V, H69Y, A71T, I72E, V75VI, T91A, I93LB
 RenG14292RenG14292KT745320PINAG48M, I54T, V82A, L90ML33F, F53L, L89LVL10V, I13V, I15V, Q18QL, L19I, K20R, E35D, M36IL, N37D, I62V, L63P, I64IV, T74AS, V77VIB
 RenG15048RenG15048KT746076PINAG48M, I54IATV, V82SL24LI, K43TL10I, I15V, K20R, E35D, M36I, R41K, F53IV, D60E, Q61N, I62IV, L63P, T74TA, I85IVB
 RenG13921RenG13921KT744949PINAM46I, G48M, I54V, L76V, V82A, I84VL33F, N83DL10IV, I13V, K20R, E35ED, M36I, N37EK, R41P, R57K, Y59YF, Q61N, L63P, L89IM, I93N, T96XB
 RenG14381RenG14381KT745409PINAM46L, G48M, I54A, V82T, L90ML33IL10I, E34D, M36I, N37E, P39Q, I62V, L63P, A71V, I72V, V77VI, I93LB
 RenG14836RenG14836KT745864PINAM46L, G48M, I54S, V82AL33F, Q58E, N83DL10I, I13V, M36L, K55KR, R57RK, Q61N, I62V, L63T, I64IV, I72IATVB
 RenG15002RenG15002KT746030PINAG48M, I54V, V82AL24I, K43KT, F53LL5LF, L10I, K20KR, E35D, M36I, R41K, I62V, L63P, T74SB
 RenG13837RenG13837KT744865PINAG48M, I54V, V82AL24I, F53LL10I, T12A, I13V, K20I, L33L_L, M36IV, N37NY, R57K, I62V, L63P, I64VB
 RenG13729RenG13729KT744757PINAG48M, I54L, V82A, I84VL24I, F53LL10I, I13M, E34EQ, L63P, K70R, A71V, I72V, V77I, I93LB
 RenG13746RenG13746KT744774PINAM46I, G48M, I50V, I54T, V82AQ58EL10I, I15V, G16E, K20R, M36I, F53C, L63T, A71V, I93LB
 RenG14626RenG14626KT745654PINAG48M, I84V, L90MF53LL10V, G16GE, K20R, E35D, M36V, N37T, Q61D, L63P, A71V, T74S, I93LB
 RenG12321RenG12321KT743349PINAG48M, I54L, V82A, I84VL24I, L33F, F53LL10I, T12P, K14R, I15V, G16E, K20T, E35H, M36L, N37D, R41K, K55R, R57K, I62V, L63N, A71TB
 RenG12337RenG12337KT743365PINAM46L, G48M, I54V, V82A, L90ML33F, F53LL10V, I15IV, N37D, K55R, R57K, Q61E, I62V, L63P, A71V, I72IR, I93LB
 RenG13370RenG13370KT744398PINAI47V, G48M, I54V, V82A, L90MV11I, F53LL10I, I13V, I15IV, L19P, K20I, E35D, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, I64V, I72IM, T74S, V75IB
 RenG12992RenG12992KT744020PINAG48M, I54V, V82A, I84VK43T, F53LL10I, I15V, G16GA, K20R, E35D, M36I, N37E, R57K, I62V, L63T, A71V, I72T, T74A, I85V, I93LB
 RenG12385RenG12385KT743413PINAI47V, G48M, I54V, V82A, L90ML33F, K43T, T74PL10V, I13V, L19I, K20R, E35D, M36I, N37D, I62V, L63P, L89I, I93LB
 RenG10019RenG10019KT741047PINAG48M, I54V, V82A, L90MF53LL10I, I13V, K20I, E34E*, M36I, N37NI, K43K*, R57RK, D60E, I62V, L63P, C67F, H69K, A71I, I72L, T74TI, N83H, C95LB
 RenG10193RenG10193KT741221PINAM46I, G48M, I54V, V82SL24I, L33F, K43T, T74PL10I, I13V, K20V, E35N, M36I, F53Y, I62V, L63A, I72V, L89M, I93LB
 RenG11050RenG11050KT742078PINAG48M, I54S, V82A, L90ML33F, K43TL10I, G16A, L19I, K20R, E35D, M36I, N37Q, R41K, R57RK, Q61HN, I62IV, L63C, C67CY, A71V, I72V, T74S, L89LF, Q92QK, I93LB
 RenG11069RenG11069KT742097PINAG48M, I50V, I54AV, V82A, L90M L10I, I15V, K20R, E35D, M36I, R41K, L63P, I64V, A71V, I93LB
 RenG11244RenG11244KT742272PINAM46I, G48M, I54V, L76V, V82A, I84VL33F, N83DL10I, I13V, K20R, E35D, M36I, N37E, R41K, R57K, Q61N, L63PB
 RenG11392RenG11392KT742420PINAG48M, I50V, V82C, L90ML33F, G73AL10I, I13V, G16A, L19V, F53I, Q61QH, L63P, H69HY, K70KE, A71T, I72E, I93LB
Lopez (2016)2002-1522002-152KT374616PINAM46I, G48M, I54S, V82F, L90ML33II15IV, Q18H, K20R, M36I, F53Y, I62V, L63P, I64V, K70T, A71V, T74E, I93LB