<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation G48M
Rx >= 1 PI
IncludeMixtures No
References 11
Patients 57
Isolates 63
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Balotta (2000)CB-223CB-223AF252078SQV, IDV M46I, G48M, V82A, L90M L10I, N37H, R41K, R57K, L63S, H69K, A71T, I93LB
Gonzales (2001)CA5067CA12630AY031636Unknown, PINAG48M, I54V, V82A, L90MF53LL10I, R41K, L63P, A71T, I72VB
Garcia-Bujalance (2005)GBS_42GBS_42AY872323RTV, NFV, SQV, LPV I47V, G48M, I54L, V82A, I84V, L90ML33F, F53LP9S, L10R, K14N, I15K, E34Q, N37D, L63P, A71V, V77I, I93LB
Rhee (2005)CA1141CA39291AY796514IDV, SQV, RTV276G48M, I50V, I54V, V82TG73CL10I, I15V, K20R, M36I, N37D, I62V, L63P, A71AITV, I72E, I85VB
  CA39293AY796515IDV, SQV, RTV, LPV333G48M, I50V, I54V, V82TG73CL10I, I15V, K20R, M36I, N37D, K55KR, I62V, L63P, A71AITV, I72E, I85VB
 CA1165CA33431AY796542SQV, NFV, IDV, RTV, Unknown, APV, LPV>282G48M, I54V, V82AF53FLL10I, T12P, K14R, E35D, M36MI, N37D, L63P, C67D, A71ATB
  CA42621AY796543SQV, NFV, IDV, RTV, Unknown, APV, LPV>347I47IV, G48M, I54V, V82ASK43T, F53FLL10I, T12P, K14R, K20KR, E35D, M36I, N37D, L63P, C67D, A71ATB
 CA1833CA33923AY796829IDV, NFV, SQV, RTV, APV330M46L, G48M, I54M, V82A, I84VL33FL10I, T12P, L19V, L23LV, L63T, A71V, I72T, T74A, I93LB
 CA5177CA38076AY798433IDV, NFV, SQV, RTV, LPV, APV251G48M, I54V, V82A, L90ML33F, K43T, F53L, G73SQ7R, L10V, I15V, K20T, E35D, M36I, R57RK, I62V, L63P, I66F, H69HR, A71V, I72LB
 SHNY-13SHNY-13 PINAM46L, G48M, I54S, V82AL33FL10I, I13IV, L63P, A71V, I93LB
Baxter (2006)12-40494049-30724DQ876155PINAG48M, I54A, V82TL24I, F53LL10I, K14R, N37ND, I62V, L63E, I64V, E65D, A71T, I72V, T74S, V77I, I93LB
 12-17691769-30430DQ876202PINAG48M, I54A, V82A, L90ML33F, K43KTL10I, E35ED, M36L, N37D, R57RK, I62V, L63P, A71I, I72V, Q92QK, I93LB
 12-10161016-30428DQ876233PINAM46L, G48M, I54S, V82A, L90LML33FL10I, G16A, L19LV, E34Q, N37D, Q61K, I62V, L63P, A71I, T74S, V77I, Q92S, I93LB
 12-10491049-30304DQ876306PINAI47V, G48M, I54M, V82A, I84V, L90ML33F, F53L, L89VL10I, I13V, L19I, E34Q, N37NS, R57K, L63M, I64IM, I66F, A71V, G73D, Q92K, C95LB
 12-15031503-30619DQ876625PINAV32I, M46I, I47V, G48M, I54M, V82AL33F, F53LL10V, K14R, G16E, K20R, E35D, M36I, K43I, K55R, R57K, I62V, L63S, A71V, I72VB
 12-21332133-30820DQ876743PINAG48M, I50V, I54V, V82A, L90ML33F, F53LL10I, I13M, L19I, E34Q, I62V, L63H, I64M, H69Q, A71V, V77I, T91S, I93L, C95FB
 12-11171117-30310DQ876773PINAG48M, I54S, V82FL33F, Q58EL10V, I13V, K20Q, M36I, I62V, L63P, A71V, V77I, I93LB
 12-14661466-30606DQ876863PINAM46I, G48M, I50V, I54S, V82A, L90MK43TL10IV, E34Q, F53Y, I62V, L63P, I64V, A71V, I72V, V77I, I85V, I93LB
 12-16401640-30320DQ876971PINAM46L, G48M, I54S, V82AL24I, L33F, K43TL10I, I13V, L19LI, M36L, F53Y, K55KR, I62V, L63V, I64V, T74AB
 12-12311231-30310DQ877014PINAI47V, G48M, I54M, V82A, L90ML33F, F53LL10I, E34Q, N37NS, L63P, A71V, I72IT, I93LB
 12-15591559-30603DQ877060PINAG48M, I54S, V82AL33LF, Q58QEL10I, L19T, K20R, M36I, I62IV, L63Q, I64V, A71V, T91AB
 12-15651565-30225DQ877065PINAG48M, I54V, L76V, V82A, L90MF53LL10I, I15V, K20R, M36I, I62V, L63AP, A71V, I72V, I93LB
 12-16501650-30324DQ877087PINAG48M, I54V, V82AL24I, F53LL10I, K20KR, M36I, N37D, L63P, A71TB
 12-16541654-30407DQ877089PINAG48M, I54V, V82A, L90MF53L, N88DL10IV, L19I, K20R, E35D, M36I, N37D, R41K, K55KR, R57K, D60E, I62V, L63S, A71V, I93L, C95FB
 12-12671267-30314DQ877134PINAG48M, I50V, I54V, V82AL33F, K43T, F53L, Q58EL10I, K20R, E35D, M36I, D60E, I62V, L63P, T74S, I85V, L89MB
 12-30023002-30219DQ877179PINAG48M, I54V, V82A, L90MF53LL10I, T12Q, I15V, L19P, K20M, E35ED, M36IV, R41K, I62V, L63P, A71I, T74S, I93LB
 12-30873087-30417DQ877189PINAG48M, I54V, V82A, L90MF53L, Q58E, G73SL10I, T12I, I13V, I15V, K20I, E35D, M36I, N37D, I62V, L63P, A71V, I72IMTB
 12-31743174-30812DQ877203PINAG48M, I54V, V82AL24I, L33F, F53LL10I, K20T, R41K, L63P, A71V, I93LB
 48-12581258-30610DQ877784PINAG48M, I54V, V82A, L90MF53LL10I, K20KR, M36MI, I62V, L63P, I64V, H69HY, A71AT, T74S, V77VI, I85V, T91TCSB
 48-14251425-30224DQ877814PINAM46L, G48M, I54A, V82AL24IL10I, L63P, A71V, I72IT, T74S, V77I, I93LB
 48-22372237-30624DQ877876PINAG48M, I54V, V82A, L90MF53L, G73TL10I, G17D, K20R, M36I, I62IV, L63P, A71V, I93LB
 48-31473147-30409DQ878058PINAM46L, G48M, I54T, V82A, L90ML33FL10I, E34Q, R41K, K55R, R57K, I62V, L63P, A71L, I93LB
 48-32273227-30521DQ878134PINAV32I, I47V, G48M, I54M, V82A, L90ML33F, F53LL10I, I13V, Q18H, L19T, K20KT, M36MI, N37S, L63P, A71V, I93L, C95FB
 48-33153315-30911DQ878216PINAG48M, I54V, V82S, L90ML10F, L33FE34Q, M36L, N37D, R41K, D60E, I62V, L63P, A71I, I72L, I93LB
 48-40944094-30410DQ878324PINAG48M, I54V, V82A, L90MF53L, G73GS, T74PSL10V, I15V, K20R, E35D, M36I, Q61E, I62V, L63P, A71V, I93LB
 48-41524152-30327DQ878384PINAG48M, I50V, I54S, V82A, L90MQ58EL10I, K20R, E34R, E35D, M36I, N37S, R41K, D60DE, I62V, L63P, A71V, V77I, I93LB
  4152-30626DQ878386PI, RTV, TPV>13G48M, I50IV, I54S, V82AT, L90MQ58EL10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93LB
  4152-40205DQ878385PI, RTV, TPV>45G48M, I54S, V82AT, I84V, L90MQ58QEL10I, K20R, E34R, E35D, M36I, N37S, R41K, R57RK, D60DE, I62V, L63P, A71V, V77I, I93LB
 48-41994199-30507DQ878431PINAV32I, I47V, G48M, I54M, V82A, L90ML33F, M46VL10V, I13IV, K14T, L19Q, K20R, E35D, M36I, N37D, I62V, L63PS, I64IM, K70KE, A71V, T74E, V77VI, L89IM, I93LB
 48-42204220-40504DQ878455PI, RTV, TPV>54M46L, G48M, I54S, V82T, I84VL33FL10I, I13V, F53Y, I62V, L63P, A71F, I72V, T74S, V77VI, P79PHSY, I93LB
 48-43024302-30806DQ878520PINAG48M, I54V, L76V, V82A, I84VL33F, F53LL10I, I13V, G16E, K20M, M36V, I62V, L63T, H69R, A71V, T74A, I93LB
 48-60576057-30709DQ878656PINAI47V, G48M, I54A, V82AF53LL10I, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63P, A71V, I93LB
 48-60756075-30717DQ878674PINAG48M, I50V, I54V, V82A, L90ML33F, F53FL, L89VT4S, L10I, I13V, L19I, K20T, E35D, M36I, N37D, I62V, L63H, H69Q, A71V, I72V, T74S, I93L, C95FB
 48-60856085-30526DQ878680PINAG48M, I54V, V82C, L90MF53L, G73SL10I, I13V, I15V, K20T, E34EQ, M36I, N37ND, Q61QE, I62V, L63P, A71V, C95LB
 48-61816181-30721DQ878753PINAG48M, I50V, I54A, V82A L10I, L19I, K20R, M36I, N37D, I62V, L63P, I64M, A71V, I72V, Q92KB
 48-62296229-30808DQ878796PINAG48M, I54S, V82A L10I, I13V, K20I, M36I, R41K, A71VB
 48-62796279-30826DQ878832PINAI47V, G48M, I54M, V82A, I84VV11I, Q58EL10I, I15V, L19P, K20I, A22V, E34Q, M36I, D60DANT, Q61H, I62V, L63P, A71I, I72T, I85V, I93LB
 48-63416341-30918DQ878864PINAM46MI, G48M, I54S, V82A, L90M L10IV, K20R, M36I, N37D, Q61QHKN, I62V, L63T, I64V, H69K, A71V, T74S, I93LB
 48-70207020-30825DQ878904PINAM46L, G48M, I54ST, V82A, I84IVL24IM, Q58EL10I, I15V, Q18I, K20RT, E35D, M36I, R41K, D60E, Q61DN, L63P, I64V, A71V, T91TA, Q92QKB
  7020-31216DQ878903PI, RTV, TPV>16M46L, G48M, I54T, V82AL24IM, Q58EL10I, I15V, Q18I, K20R, E35D, M36I, R41K, D60E, Q61D, L63P, I64V, A71V, T91TA, Q92QKB
 48-70217021-30825DQ878905PINAG48M, I54S, V82SL24I, L33F, Q58EL10I, G16A, E34Q, E35D, M36I, N37D, R57RK, I62V, L63P, A71V, I72IV, Q92KB
 48-71677167-30613DQ879004PINAM46L, G48M, I54S, V82A, L90ML33FL10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I72V, I93LB
 48-72067206-30911DQ879031PINAG48M, I54V, V82AL24IL10I, T12N, L19I, K20KR, M36MI, N37D, L63P, A71T, V77VI, N83S, T91TAB
Rosen-Zvi (2008)7408p74-5 SQV, NFV, LPV503G48M, I50V, I54V, V82A, L90MK43T, F53L, G73SL10I, I15V, K20R, E35D, M36I, N37D, R57K, Q61QR, I62V, L63P, A71M, I93LB
Rhee (2009)CA1524CA63895FJ983143SQV, RTV, APV, LPV429G48M, I54V, V82A, I84VF53LL10I, V11L, I13V, K14KR, A22V, E35D, M36I, N37D, I62V, L63P, A71V, T74S, T91S, Q92KB
 CA1833CA50894GQ208286IDV, NFV, SQV, RTV, APV440M46L, G48M, I54M, V82A, I84VV11VI, L33FL10I, T12P, I13V, K14R, L19V, L63T, A71V, I72T, T74A, P79PS, I93LB
Dau (2010)06467A06467AGU581750PINAM46I, G48M, I54S, V82A, L90ML33FL10I, L19LI, E34Q, I62V, L63P, I64M, A71V, V77I, I93LB
Rhee (2010)CA7849CA68594GQ212322IDV, APV, SQV, LPV486I47V, G48M, I54V, V82T, I84VK43T, F53LL10I, K20R, E35D, M36I, I62V, L63P, I66F, A71V, Q92RB
Jones (2012)175671175671JN670367PINAG48M, I84VN83DI13V, E35D, M36I, R57K, I62V, I64V, T74SB
 176766176766JN670411PINAG48M, I54V, V82A, L90MF53LL10I, I15V, M36MI, N37ND, L63P, A71V, I93LB
 181681181681JN670580PINAM46L, G48M, I54A, V82A, L90ML33LF, F53LL10I, T12S, K14R, E34EK, N37E, K55R, I62V, L63P, A71I, I72V, V77I, Q92K, I93LB
 203414203414JN671310PINAG48M, I50V, I54A, V82AK43T, F53L, G73SL10V, I15V, L19P, K20I, E35D, M36I, R41K, R57RK, I62V, L63P, A71V, I85IV, Q92KB
Grossman (2014)2727KF135038LPV52G48M, I54V, V82AL24I, F53LL10I, K20R, E35D, M36I, R41RK, R57K, D60E, Q61D, L63PB