<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation I47A
Rx >= 1 PI
IncludeMixtures No
References 12
Patients 39
Isolates 42
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Kempf (2001)DK-90148359_d742 IDV, LPV253V32I, M46I, I47A L10I, I62V, L63P, V77I, Q92K, I93L, C95FB
  8359_d1091 IDV, LPV302V32I, M46I, I47A L10I, I62V, L63P, V77I, V82I, Q92K, I93L, C95FB
Friend (2004)PNT_pat1PNT_pat1 LPV34V32I, M46MI, I47A T12S, I13V, I15V, L19I, Q61NB
Gomez-Carrillo (2004)118789118789AY365957PINAI47A, L90ML33F, G73T, L89VL10IV, I13V, N37H, R41N, I62V, L63P, H69Y, V77IB
Kagan (2005)166701166701 PINAV32I, I47A, L90M K20R, E35D, M36I, N37D, I62V, L63P, A71AT, I93LB
 164917164917 PINAV32I, I47A, L90ML10FT12P, K14R, I15V, G16E, K20T, E34Q, I62V, L63H, A71T, V77I, I93LB
 165220165220 PINAM46L, I47A T12P, I13V, N37D, R57K, L63P, A71T, V82IB
 175236175236 PINAV32I, I47A, L90ML33F, G73AI13V, R41K, K43R, K45R, L63P, A71T, V77I, I93LB
 175848175848 PINAV32I, M46I, I47A, L90ML10F, L89VT4A, I13V, K20T, L33V, I62V, L63P, H69Y, A71V, I93LB
Rhee (2005)CA5951CA37761AY797366IDV, LPV99V32I, M46ML, I47A L10LI, T12PS, L19I, E35D, M36I, R41RK, Q61QH, L63P, I64V, A71AV, I93LB
 CA8033CA33558AY797661IDV, SQV, RTV, LPV, Unknown>180V32I, M46I, I47A, V82A, L90M L10I, G16A, L19Q, N37S, R41K, K45R, L63P, A71V, I72V, Q92K, I93LB
Baxter (2006)12-13371337-30414DQ875978PINAV32I, I47A, L90ML10F, F53LK20R, E35D, M36I, R41K, K45KR, I62V, L63P, H69Y, A71V, V77IB
 12-11371137-30528DQ876831PINAV32I, M46I, I47A I13V, L63P, I72TB
 12-11611161-30529DQ876929PINAV32I, M46I, I47A, L90ML23LI, F53FLL10V, K20R, E35D, M36I, N37E, L63P, A71LV, V77I, I93LB
 12-30633063-30325DQ877224PINAM46I, I47A, I84V, L90ML33I, G73GSL10I, L24F, N37D, K45R, I62V, L63P, A71V, I72L, V77I, I93LB
 48-11691169-30910DQ877355PINAV32I, M46L, I47A, L90M I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61Y, V77I, V82IB
 48-12031203-30703DQ877747PINAV32I, M46I, I47A, V82A, L90M L10V, I15IV, K20R, M36I, K45R, K55N, D60DE, I62V, L63P, A71V, I93LB
 48-22032203-30401DQ877856PINAV32I, M46I, I47AQ58QEL10V, L63P, A71T, I72V, V77I, I85V, Q92KB
 48-26062606-30623DQ877898PINAV32I, M46I, I47A, L90M L10I, R41K, I62V, L63P, I64V, I85V, I93LB
 48-30963096-30415DQ878003PINAV32I, M46I, I47A, L90ML10F, Q58EI15V, E35D, M36I, I62V, L63P, A71TB
 48-32543254-30610DQ878158PINAV32I, M46I, I47A, L90ML23I, F53FLL10I, I15V, K20T, E35N, M36I, N37D, I62V, L63P, I66IV, A71L, I72V, V77I, I93LB
 48-32923292-30924DQ878197PINAM46I, I47A, I84VF53LL10I, I13V, K20M, E34Q, N37D, L63P, I64V, V77I, L89MB
 48-60356035-30423DQ878634PINAV32I, M46I, I47A, V82T L10V, T12S, L19T, M36MIV, Q61E, L63P, A71V, I72VB
 48-62606260-30828DQ878817PINAV32I, M46I, I47A, V82AK43TL10I, K20R, M36I, I62V, L63T, I64V, E65D, A71V, I93ILB
 48-62766276-30826DQ878829PINAM46I, I47A, I84V, L90MV11IL10I, I15V, L19Q, K20I, N37D, K45R, R57K, I62V, L63P, A71V, I72R, I85V, I93LB
 48-63046304-30910DQ878843PINAM46I, I47A, I84V L10V, I13V, I15V, G16GE, K20I, R41K, H69K, T74A, V77I, L89MB
 48-71027102-30728DQ878955PINAM46MI, I47A, I84V I13V, K20KT, L33V, N37C, R57K, L63P, I64VB
  7102-40225DQ878956PI, RTV, TPV>30M46I, I47A, I84V L10V, I13V, K20T, L33V, M36I, N37C, R57K, L63P, I64VB
 48-71047104-30818DQ878958PINAV32I, I47A, V82A I15IV, K20R, M36I, N37D, I62V, L63P, A71AV, I72V, I93LB
 48-71097109-30922DQ878962PINAV32I, M46MIL, I47A, L90ML33FL10I, E34Q, R41K, I62V, L63P, C67X, A71T, I72T, V77I, I93LB
 48-71697169-30617DQ879006PINAV32I, I47A, V82VA L10V, I13V, L19I, K20R, E35D, M36I, N37E, R57RK, L63P, A71TB
 48-92679267-30915DQ877518PINAV32I, M46I, I47A L10V, G16A, E35D, M36MIV, N37T, I62V, L63Q, I64V, A71AV, I93LB
 48-92649264-30923DQ877613PINAV32I, M46I, I47A, V82A L10I, L63P, A71T, V77I, I93LB
 48-72297229-30930DQ879042PINAV32I, I47A, L90MV11I, G73SL10I, T12S, I13V, I15V, K20I, E34K, M36I, N37S, R41K, I62V, L63P, A71T, I72TB
De Meyer (2009)LPV08LPV08-48w PI, LPV>48V32I, M46I, I47A, I54M, V82A, L90M L10I, L63P, I64V, A71V, V77I, I85V, I93LB
 LPV15LPV15-48w PI, LPV>48M46I, I47A, I50VL33FL10I, I64M, A71VB
Rhee (2009)CA5951CA50780FJ983192IDV, LPV175V32I, M46L, I47A, V82AL33FL10I, T12P, L19I, E35D, M36I, L63P, I64V, A71V, I72V, I93LB
Dau (2010)06333A06333AGU581733PINAV32I, I47A, L90MV11I, L89VL10I, I13V, K20V, M36I, I62V, L63P, A71IB
 08063A08063AGU581895PINAV32I, I47A, V82VAIT, L90LMQ58QEL10I, K20R, E35D, M36I, N37D, I62V, L63P, A71AITV, I93LB
Rhee (2010)CA27759CA64169GQ211963Unknown, LPV>104V32I, M46MIL, I47A, V82A, L90ML33FL10IT, I13V, M36I, R41RK, L63P, K70E, A71V, I93LB
Rodrigues (2010)316_07BR07SC316GQ401334NFV, LPV V32VI, I47A T12P, I13V, I15V, Q18L, K20T, M36I, K45R, D60E, Q61E, I62V, L63P, C67Y, L89IMB
Jones (2012)146265146265JN669674PINAV32I, M46I, I47A, V82AL33FL10I, G16GA, M36I, N37NS, I62V, L63P, A71V, I72T, I85V, I93LB