Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	I47A
Rx	>= 1 PI
IncludeMixtures	No

References	12
Patients	39
Isolates	42

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Kempf (2001)	DK-9014	8359_d742		IDV, LPV	253	V32I, M46I, I47A		L10I, I62V, L63P, V77I, Q92K, I93L, C95F	B
		8359_d1091		IDV, LPV	302	V32I, M46I, I47A		L10I, I62V, L63P, V77I, V82I, Q92K, I93L, C95F	B
Friend (2004)	PNT_pat1	PNT_pat1		LPV	34	V32I, M46MI, I47A		T12S, I13V, I15V, L19I, Q61N	B
Gomez-Carrillo (2004)	118789	118789	AY365957	PI	NA	I47A, L90M	L33F, G73T, L89V	L10IV, I13V, N37H, R41N, I62V, L63P, H69Y, V77I	B
Kagan (2005)	166701	166701		PI	NA	V32I, I47A, L90M		K20R, E35D, M36I, N37D, I62V, L63P, A71AT, I93L	B
	164917	164917		PI	NA	V32I, I47A, L90M	L10F	T12P, K14R, I15V, G16E, K20T, E34Q, I62V, L63H, A71T, V77I, I93L	B
	165220	165220		PI	NA	M46L, I47A		T12P, I13V, N37D, R57K, L63P, A71T, V82I	B
	175236	175236		PI	NA	V32I, I47A, L90M	L33F, G73A	I13V, R41K, K43R, K45R, L63P, A71T, V77I, I93L	B
	175848	175848		PI	NA	V32I, M46I, I47A, L90M	L10F, L89V	T4A, I13V, K20T, L33V, I62V, L63P, H69Y, A71V, I93L	B
Rhee (2005)	CA5951	CA37761	AY797366	IDV, LPV	99	V32I, M46ML, I47A		L10LI, T12PS, L19I, E35D, M36I, R41RK, Q61QH, L63P, I64V, A71AV, I93L	B
	CA8033	CA33558	AY797661	IDV, SQV, RTV, LPV, Unknown	>180	V32I, M46I, I47A, V82A, L90M		L10I, G16A, L19Q, N37S, R41K, K45R, L63P, A71V, I72V, Q92K, I93L	B
Baxter (2006)	12-1337	1337-30414	DQ875978	PI	NA	V32I, I47A, L90M	L10F, F53L	K20R, E35D, M36I, R41K, K45KR, I62V, L63P, H69Y, A71V, V77I	B
	12-1137	1137-30528	DQ876831	PI	NA	V32I, M46I, I47A		I13V, L63P, I72T	B
	12-1161	1161-30529	DQ876929	PI	NA	V32I, M46I, I47A, L90M	L23LI, F53FL	L10V, K20R, E35D, M36I, N37E, L63P, A71LV, V77I, I93L	B
	12-3063	3063-30325	DQ877224	PI	NA	M46I, I47A, I84V, L90M	L33I, G73GS	L10I, L24F, N37D, K45R, I62V, L63P, A71V, I72L, V77I, I93L	B
	48-1169	1169-30910	DQ877355	PI	NA	V32I, M46L, I47A, L90M		I15V, K20R, E35D, M36I, N37D, R41K, R57K, Q61Y, V77I, V82I	B
	48-1203	1203-30703	DQ877747	PI	NA	V32I, M46I, I47A, V82A, L90M		L10V, I15IV, K20R, M36I, K45R, K55N, D60DE, I62V, L63P, A71V, I93L	B
	48-2203	2203-30401	DQ877856	PI	NA	V32I, M46I, I47A	Q58QE	L10V, L63P, A71T, I72V, V77I, I85V, Q92K	B
	48-2606	2606-30623	DQ877898	PI	NA	V32I, M46I, I47A, L90M		L10I, R41K, I62V, L63P, I64V, I85V, I93L	B
	48-3096	3096-30415	DQ878003	PI	NA	V32I, M46I, I47A, L90M	L10F, Q58E	I15V, E35D, M36I, I62V, L63P, A71T	B
	48-3254	3254-30610	DQ878158	PI	NA	V32I, M46I, I47A, L90M	L23I, F53FL	L10I, I15V, K20T, E35N, M36I, N37D, I62V, L63P, I66IV, A71L, I72V, V77I, I93L	B
	48-3292	3292-30924	DQ878197	PI	NA	M46I, I47A, I84V	F53L	L10I, I13V, K20M, E34Q, N37D, L63P, I64V, V77I, L89M	B
	48-6035	6035-30423	DQ878634	PI	NA	V32I, M46I, I47A, V82T		L10V, T12S, L19T, M36MIV, Q61E, L63P, A71V, I72V	B
	48-6260	6260-30828	DQ878817	PI	NA	V32I, M46I, I47A, V82A	K43T	L10I, K20R, M36I, I62V, L63T, I64V, E65D, A71V, I93IL	B
	48-6276	6276-30826	DQ878829	PI	NA	M46I, I47A, I84V, L90M	V11I	L10I, I15V, L19Q, K20I, N37D, K45R, R57K, I62V, L63P, A71V, I72R, I85V, I93L	B
	48-6304	6304-30910	DQ878843	PI	NA	M46I, I47A, I84V		L10V, I13V, I15V, G16GE, K20I, R41K, H69K, T74A, V77I, L89M	B
	48-7102	7102-30728	DQ878955	PI	NA	M46MI, I47A, I84V		I13V, K20KT, L33V, N37C, R57K, L63P, I64V	B
		7102-40225	DQ878956	PI, RTV, TPV	>30	M46I, I47A, I84V		L10V, I13V, K20T, L33V, M36I, N37C, R57K, L63P, I64V	B
	48-7104	7104-30818	DQ878958	PI	NA	V32I, I47A, V82A		I15IV, K20R, M36I, N37D, I62V, L63P, A71AV, I72V, I93L	B
	48-7109	7109-30922	DQ878962	PI	NA	V32I, M46MIL, I47A, L90M	L33F	L10I, E34Q, R41K, I62V, L63P, C67X, A71T, I72T, V77I, I93L	B
	48-7169	7169-30617	DQ879006	PI	NA	V32I, I47A, V82VA		L10V, I13V, L19I, K20R, E35D, M36I, N37E, R57RK, L63P, A71T	B
	48-9267	9267-30915	DQ877518	PI	NA	V32I, M46I, I47A		L10V, G16A, E35D, M36MIV, N37T, I62V, L63Q, I64V, A71AV, I93L	B
	48-9264	9264-30923	DQ877613	PI	NA	V32I, M46I, I47A, V82A		L10I, L63P, A71T, V77I, I93L	B
	48-7229	7229-30930	DQ879042	PI	NA	V32I, I47A, L90M	V11I, G73S	L10I, T12S, I13V, I15V, K20I, E34K, M36I, N37S, R41K, I62V, L63P, A71T, I72T	B
De Meyer (2009)	LPV08	LPV08-48w		PI, LPV	>48	V32I, M46I, I47A, I54M, V82A, L90M		L10I, L63P, I64V, A71V, V77I, I85V, I93L	B
	LPV15	LPV15-48w		PI, LPV	>48	M46I, I47A, I50V	L33F	L10I, I64M, A71V	B
Rhee (2009)	CA5951	CA50780	FJ983192	IDV, LPV	175	V32I, M46L, I47A, V82A	L33F	L10I, T12P, L19I, E35D, M36I, L63P, I64V, A71V, I72V, I93L	B
Dau (2010)	06333A	06333A	GU581733	PI	NA	V32I, I47A, L90M	V11I, L89V	L10I, I13V, K20V, M36I, I62V, L63P, A71I	B
	08063A	08063A	GU581895	PI	NA	V32I, I47A, V82VAIT, L90LM	Q58QE	L10I, K20R, E35D, M36I, N37D, I62V, L63P, A71AITV, I93L	B
Rhee (2010)	CA27759	CA64169	GQ211963	Unknown, LPV	>104	V32I, M46MIL, I47A, V82A, L90M	L33F	L10IT, I13V, M36I, R41RK, L63P, K70E, A71V, I93L	B
Rodrigues (2010)	316_07	BR07SC316	GQ401334	NFV, LPV		V32VI, I47A		T12P, I13V, I15V, Q18L, K20T, M36I, K45R, D60E, Q61E, I62V, L63P, C67Y, L89IM	B
Jones (2012)	146265	146265	JN669674	PI	NA	V32I, M46I, I47A, V82A	L33F	L10I, G16GA, M36I, N37NS, I62V, L63P, A71V, I72T, I85V, I93L	B

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