<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation I47A
Rx >= 1 PI
IncludeMixtures No
References 16
Patients 80
Isolates 82
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Kempf (2001)DK-90148359_d742 IDV, LPV253V32I, M46I, I47A L10I, I62V, L63P, V77I, Q92K, I93L, C95FB
  8359_d1091 IDV, LPV302V32I, M46I, I47A L10I, I62V, L63P, V77I, V82I, Q92K, I93L, C95FB
Friend (2004)PNT_pat1PNT_pat1 LPV34V32I, M46MI, I47A T12S, I13V, I15V, L19I, Q61NB
Gomez-Carrillo (2004)118789118789AY365957PINAI47A, L90ML33F, G73T, L89VL10IV, I13V, N37H, R41N, I62V, L63P, H69Y, V77IB
Kagan (2005)166701166701 PINAV32I, I47A, L90M K20R, E35D, M36I, N37D, I62V, L63P, A71AT, I93LB
 164917164917 PINAV32I, I47A, L90ML10FT12P, K14R, I15V, G16E, K20T, E34Q, I62V, L63H, A71T, V77I, I93LB
 165220165220 PINAM46L, I47A T12P, I13V, N37D, R57K, L63P, A71T, V82IB
 175236175236 PINAV32I, I47A, L90ML33F, G73AI13V, R41K, K43R, K45R, L63P, A71T, V77I, I93LB
 175848175848 PINAV32I, M46I, I47A, L90ML10F, L89VT4A, I13V, K20T, L33V, I62V, L63P, H69Y, A71V, I93LB
Rhee (2005)CA5951CA37761AY797366IDV, LPV99V32I, M46ML, I47A L10LI, T12PS, L19I, E35D, M36I, R41RK, Q61QH, L63P, I64V, A71AV, I93LB
 CA8033CA33558AY797661IDV, SQV, RTV, LPV, Unknown>180V32I, M46I, I47A, V82A, L90M L10I, G16A, L19Q, N37S, R41K, K45R, L63P, A71V, I72V, Q92K, I93LB
Baxter (2006)12-13371337-30414DQ875978PINAV32I, I47A, L90ML10F, F53LK20R, E35D, M36I, R41K, K45KR, I62V, L63P, H69Y, A71V, V77IB
 12-11371137-30528DQ876831PINAV32I, M46I, I47A I13V, L63P, I72TB
 12-11611161-30529DQ876929PINAV32I, M46I, I47A, L90ML23LI, F53FLL10V, K20R, E35D, M36I, N37E, L63P, A71LV, V77I, I93LB
 12-30633063-30325DQ877224PINAM46I, I47A, I84V, L90ML33I, G73GSL10I, L24F, N37D, K45R, I62V, L63P, A71V, I72L, V77I, I93LB
 48-12031203-30703DQ877747PINAV32I, M46I, I47A, V82A, L90M L10V, I15IV, K20R, M36I, K45R, K55N, D60DE, I62V, L63P, A71V, I93LB
 48-22032203-30401DQ877856PINAV32I, M46I, I47AQ58QEL10V, L63P, A71T, I72V, V77I, I85V, Q92KB
 48-26062606-30623DQ877898PINAV32I, M46I, I47A, L90M L10I, R41K, I62V, L63P, I64V, I85V, I93LB
 48-30963096-30415DQ878003PINAV32I, M46I, I47A, L90ML10F, Q58EI15V, E35D, M36I, I62V, L63P, A71TB
 48-32543254-30610DQ878158PINAV32I, M46I, I47A, L90ML23I, F53FLL10I, I15V, K20T, E35N, M36I, N37D, I62V, L63P, I66IV, A71L, I72V, V77I, I93LB
 48-32923292-30924DQ878197PINAM46I, I47A, I84VF53LL10I, I13V, K20M, E34Q, N37D, L63P, I64V, V77I, L89MB
 48-60356035-30423DQ878634PINAV32I, M46I, I47A, V82T L10V, T12S, L19T, M36MIV, Q61E, L63P, A71V, I72VB
 48-62606260-30828DQ878817PINAV32I, M46I, I47A, V82AK43TL10I, K20R, M36I, I62V, L63T, I64V, E65D, A71V, I93ILB
 48-62766276-30826DQ878829PINAM46I, I47A, I84V, L90MV11IL10I, I15V, L19Q, K20I, N37D, K45R, R57K, I62V, L63P, A71V, I72R, I85V, I93LB
 48-63046304-30910DQ878843PINAM46I, I47A, I84V L10V, I13V, I15V, G16GE, K20I, R41K, H69K, T74A, V77I, L89MB
 48-71027102-30728DQ878955PINAM46MI, I47A, I84V I13V, K20KT, L33V, N37C, R57K, L63P, I64VB
 48-71047104-30818DQ878958PINAV32I, I47A, V82A I15IV, K20R, M36I, N37D, I62V, L63P, A71AV, I72V, I93LB
 48-71097109-30922DQ878962PINAV32I, M46MIL, I47A, L90ML33FL10I, E34Q, R41K, I62V, L63P, C67X, A71T, I72T, V77I, I93LB
 48-71697169-30617DQ879006PINAV32I, I47A, V82VA L10V, I13V, L19I, K20R, E35D, M36I, N37E, R57RK, L63P, A71TB
 48-92679267-30915DQ877518PINAV32I, M46I, I47A L10V, G16A, E35D, M36MIV, N37T, I62V, L63Q, I64V, A71AV, I93LB
 48-92649264-30923DQ877613PINAV32I, M46I, I47A, V82A L10I, L63P, A71T, V77I, I93LB
 48-72297229-30930DQ879042PINAV32I, I47A, L90MV11I, G73SL10I, T12S, I13V, I15V, K20I, E34K, M36I, N37S, R41K, I62V, L63P, A71T, I72TB
Waleria-Aleixo (2008)08PR04021008PR040210FJ591240PINAV32I, M46I, I47A, I54V, V82AL33FL10I, L19I, N37D, R41T, K45R, I66F, A71VB
 RES317RES317FJ592006PINAV32I, M46I, I47A, V82A, L90MK43TL10V, I15V, M36MI, K55R, I62V, L63P, I64IM, H69Q, A71V, I93LB
 08PR05022608PR050226FJ591256PINAV32I, I47A L10I, T12P, L19I, E35D, M36I, L63P, A71ATB
De Meyer (2009)LPV08LPV08-48w PI, LPV>48V32I, M46I, I47A, I54M, V82A, L90M L10I, L63P, I64V, A71V, V77I, I85V, I93LB
 LPV15LPV15-48w PI, LPV>48M46I, I47A, I50VL33FL10I, I64M, A71VB
Rhee (2009)CA5951CA50780FJ983192IDV, LPV175V32I, M46L, I47A, V82AL33FL10I, T12P, L19I, E35D, M36I, L63P, I64V, A71V, I72V, I93LB
Dau (2010)06333A06333AGU581733PINAV32I, I47A, L90MV11I, L89VL10I, I13V, K20V, M36I, I62V, L63P, A71IB
 07867A07867AGU581877PINAV32I, M46I, I47A, L90ML10F, L89VT4A, I13V, K20T, L33V, I62V, L63P, H69Y, A71V, I93LB
 08063A08063AGU581895PINAV32I, I47A, V82VAIT, L90LMQ58QEL10I, K20R, E35D, M36I, N37D, I62V, L63P, A71AITV, I93LB
Rhee (2010)CA27759CA64169GQ211963Unknown, LPV>104V32I, M46MIL, I47A, V82A, L90ML33FL10IT, I13V, M36I, R41RK, L63P, K70E, A71V, I93LB
Rodrigues (2010)316_07BR07SC316GQ401334NFV, LPV V32VI, I47A T12P, I13V, I15V, Q18L, K20T, M36I, K45R, D60E, Q61E, I62V, L63P, C67Y, L89IMB
Jones (2012)146265146265JN669674PINAV32I, M46I, I47A, V82AL33FL10I, G16GA, M36I, N37NS, I62V, L63P, A71V, I72T, I85V, I93LB
Diaz (2015)RenG16424RenG16424KT747452PINAV32I, M46I, I47A, L90M L10I, I15L, L19I, E34EQ, L63P, I64V, A71AV, I72V, V77I, I93LB
 RenG16056RenG16056KT747084PINAV32I, M46I, I47A, V82VCFG L10LV, T12P, K14R, I15V, G16E, K20T, P39S, L63P, A71V, V77VIB
 RenG16146RenG16146KT747174PINAV32I, I47A T12P, I15V, L19Q, K20R, E35D, M36I, R41K, I62V, L63P, I64L, I72EB
 RenG15665RenG15665KT746693PINAV32I, M46I, I47A, V82CQ58EK55R, L63PB
 RenG16843RenG16843KT747871PINAV32I, M46L, I47A, V82A, L90LM L10I, T12N, G16GA, E35D, M36I, N37D, I62IV, L63P, A71V, I93LB
 RenG16722RenG16722KT747750PINAV32I, I47A, V82C L10V, T12K, L19I, E34Q, M36MI, K55N, L63P, K70TB
 RenG16510RenG16510KT747538PINAV32I, M46I, I47A, V82AL10FL63P, A71V, I72IVB
 RenG15980RenG15980KT747008PINAV32I, M46I, I47AL89VI13V, I15V, K20T, N37S, L63P, K70R, A71V, V77I, V82I, I93LB
 RenG14475RenG14475KT745503PINAV32I, M46ML, I47A I13V, E35ED, M36I, I62V, L63P, I64V, E65D, I72V, V82IB
 RenG13633RenG13633KT744661PINAM46I, I47A, I84V, L90ML10F, V11I, F53L, G73S, L89VI13V, I15V, K20T, E35N, M36I, R41K, K55R, R57K, Q61N, L63P, A71V, T74S, T91S, I93LB
 RenG13761RenG13761KT744789PINAD30N, M46L, I47AN88DI13V, K20T, L33V, E35G, M36I, R41K, K45R, K55N, Q61H, I62V, L63PB
 RenG14345RenG14345KT745373PINAD30N, M46I, I47AF53L, G73GS, N83D, N88DL10I, K20R, A22V, E34D, E35N, M36I, N37E, R41K, Q61QH, I62V, L63P, A71V, I72KT, I85V, I93LB
 RenG13663RenG13663KT744691PINAV32I, M46I, I47AL24LIE35D, M36I, N37E, R41K, Q61QE, I62V, L63P, I64V, K70R, V77VI, V82VIB
 RenG13798RenG13798KT744826PINAV32I, M46I, I47A I13V, I15V, K20T, M36I, R41K, L63P, I64V, V82VIB
 RenG14765RenG14765KT745793PINAV32I, M46L, I47A I13V, E35D, M36I, I62V, L63P, I64V, E65D, I72V, V82IB
 RenG14425RenG14425KT745453PINAV32I, I47A, L90M L10I, I13V, L19I, E35D, M36I, N37E, K43R, R57K, Q61N, L63P, V82I, L89IB
 RenG13924RenG13924KT744952PINAV32I, M46L, I47A, V82A L10V, I15V, G16E, L19V, K20T, E34Q, M36I, N37E, R57K, I62V, L63H, A71T, I72VB
 RenG14760RenG14760KT745788PINAV32I, I47A L10I, I13V, L19V, K20T, M36L, N37D, R57RK, I62V, L63T, I64V, E65ED, A71V, I72V, V82IB
 RenG12008RenG12008KT743036PINAV32I, M46IL, I47A E35D, M36I, I62V, L63P, I64IV, H69Q, I72IV, V77VI, V82VIB
 RenG12120RenG12120KT743148PINAV32I, M46I, I47A, L90M L10I, G17D, K20V, E35D, M36I, N37D, R57K, Q61N, L63T, I64V, E65D, A71V, I72T, T74S, I93LB
 RenG11829RenG11829KT742857PINAM46I, I47A, I84V, L90MF53LL10Y, I13V, I15V, K20IT, E35DG, M36I, R41K, R57K, Q61N, L63P, A71V, T74S, L89I, I93LB
 RenG12410RenG12410KT743438PINAV32I, M46I, I47A, I50VQ58EE34Q, M36A, P39S, I62V, L63T, I64L, A71V, I72T, V77I, I93LB
 RenG12007RenG12007KT743035PINAM46I, I47A, I84V, L90MF53L, Q58EL10I, E34Q, N37S, R41K, D60E, I62V, L63P, K70KR, A71V, V77I, L89M, I93LB
 RenG10496RenG10496KT741524PINAV32I, M46I, I47A, L90M I13V, I15V, L19K, K20I, M36V, N37S, R57K, L63P, A71V, V82I, L89I, I93MB
 RenG10951RenG10951KT741979PINAV32I, I47AM46VN37D, L63P, H69YB
 RenG10855RenG10855KT741883PINAV32I, M46I, I47A, V82C E21K, L63P, V77IB
 RenG11517RenG11517KT742545PINAV32I, I47AG73TL10I, I13V, I15V, L19I, K20R, E35D, M36I, N37E, I62V, L63P, V82IB
 RenG11552RenG11552KT742580PINAD30N, M46L, I47AN88DI13V, K20T, L33V, E35G, M36I, R41K, K45R, K55N, Q61H, I62V, L63PB
 RenG10588RenG10588KT741616PINAD30N, I47AN88DL10I, I13V, K20I, E35N, M36I, N37T, R41K, K45R, K55Q, L63P, I64V, A71V, I72V, T74SB
 RenG10846RenG10846KT741874PINAD30N, M46L, I47AN88DL10V, T12K, I13V, I15V, L19M, K20IM, E35G, M36I, N37E, I62V, L63P, K70EB
 RenG10315RenG10315KT741343PINAM46L, I47A, L90M L10V, T12E, K55KR, R57RK, L63P, H69Q, A71V, I72V, V77I, I93LB
 RenG11271RenG11271KT742299PINAV32I, I47A L10V, T12K, L19I, E34Q, K55N, L63P, K70TB
Ramkissoon (2015)4UH00144UH0014JQ237865LPV V32I, I47A, V82AK43TL10V, T12Q, I15V, L19T, K20R, M36I, L63P, A71TB
Lopez (2016)2003-1602003-160KT374794PINAV32I, I47A K14R, I15V, G16GW, L19I, K20T, M36I, R41K, I62V, I64V, T74AB
 2003-1422003-142KT374777PINAV32I, M46L, I47A L19I, M36V, N37D, L63P, I64ITB
 2003-0132003-013KT374642PINAV32I, M46I, I47A, L90LM K20KT, E35D, M36MV, N37Q, L63P, A71V, V77VI, V82VI, I93LB
 2002-0732002-073KT374547PINAV32I, M46I, I47A, V82A I15V, L63PB
 2001-1052001-105KT374470PINAM46I, I47A, L90M K20R, V32X, E35D, M36I, N37D, L63P, C67W, G68E, A71V, V77I, I93LB