<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation M36L
Rx PI-naive
IncludeMixtures No
References 70
Patients 191
Isolates 203
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Hammer (1997)ACTG320_36113611 None   L19I, K20R, L33V, M36L, R41K, Q61H, I64IV, E65ED, V82VI, L89LM, I93ILMB
Eshleman (2001)A107AF357708AF357708None   M36L, I64VB
Gonzales (2001)CA2205CA7989AY030827None   M36L, N37A, I62V, L63P, I64V, I72VB
 CA4462CA11024AY031306None   I13V, K14R, I15V, M36L, N37E, I62V, L63S, I64VB
 CA4912CA12109AY031552None   L10V, I15V, M36L, N37T, R41K, D60E, I62V, L63PB
Holguin (2001)SP_M2067SP_M2067AF247017None   K14R, M36L, I62V, L63PB
Perno (2001)PCF_Pat20PCF1881AF376597None   L10I, I13V, L19I, M36L, N37T, I62V, L63P, L89M, C95FB
 PCF_Pat23PCF3776AF376699None   I15V, M36L, N37CS, I62V, I64VB
 PCF_Pat105PCF420AF376538None  L33IK14R, M36L, Q61E, L63P, I64V, I93LB
 PCF_Pat185PCF2302AF376627None   M36L, N37S, L38X, L63P, I64IVB
Servais (2001)JS97252JS97252AJ010717None   I3X, M36L, N37X, R41K, R57K, L63P, A71T, V77I, I93LB
 JS97251JS97251AJ279672None   M36L, R41K, R57K, L63P, A71T, V77I, I93LB
Cuevas (2002)CU53CU53AF425434None  L10LFM36L, N37S, I64VB
Brindeiro (2003)BRNE265BRNE265AY213333None   L10V, T12S, I15V, M36L, R41K, I62V, L63C, A71T, C95SB
Hanna (2003)HG010HG010AY049687None   M36L, N37S, R41K, L63PB
 HG044HG044AY049641None   M36L, N37E, I62V, L63PB
Jorgensen (2003)JLB_Pat57HIM419483AJ419483None   M36L, N37NS, I62V, L63LP, I64VB
Shafer (2003)A384_13831383aEF548229None   M36L, N37K, R41K, I64VB
 A384_10221022aEF548559None   Q18K, M36L, N37S, R57K, I62V, L63P, H69N, F99XB
 A384_05650565aEF548842None   M36L, N37S, I62V, L63P, I64VB
 A384_56115611aEF549132None   I15IV, M36L, N37D, R57K, I62V, L63HQ, A71V, I93L, F99XB
 A384_01980198aEF549307None   W6WL, L10I, G16E, M36L, I62V, L63S, I64VB
Soares (2003)BRBS465BRBS465AF527179None   K14KR, G16E, E35D, M36L, I62V, L63H, I64VB
Vaughan (2003)VHE_Pat31VHE031prrtAY267280None   I15V, L19Q, E35D, M36L, D60E, Q61E, L63P, A71TB
Gulick (2004)RG287RG287w0 None   T12P, K14KR, G16GE, M36L, R41RK, I62V, L63S, I64VB
  RG287w18 None   T12P, K14KR, G16GE, M36L, I62V, L63S, I64VB
 RG433RG433w-2 None   L10I, I13V, G16E, M36L, N37S, L63TB
  RG433w64 None   L10I, I13V, G16E, M36L, N37S, L63TB
  RG433w88 None   L10I, I13V, G16E, M36L, N37S, L63TB
 RG461RG461w0 None   L10I, K14R, I15V, M36L, N37D, R57K, I62V, L63H, A71T, I93LB
  RG461w24 None   L10I, I15V, M36L, N37D, R57K, I62V, L63H, A71T, I93LB
Kuritzkes (2004)KDR_pat136A0159AY527976None   M36L, N37S, I62V, L63P, I93LB
  A0160AY527977None   M36L, N37S, I62V, L63P, I93LB
  A0161AY527978None   M36L, N37S, I62V, L63P, I93LB
  A0162AY527979None   M36L, N37S, I62V, L63P, I93LB
  A0163AY527980None   M36L, N37S, I62V, L63P, I93LB
 KDR_pat137A0164AY527981None   I15IV, M36L, N37S, I62V, L63P, I93LB
  A0165AY527982None   M36L, N37S, I62V, L63P, I93LB
  A0166AY527983None   M36L, N37S, I62V, L63P, I93LB
Machado (2004)cs276cs276AY569836None   L10I, I13V, M36L, R57K, L63S, I64VB
Grossman (2005)2430724307PR349 None   W6L, T12S, M36L, D60DE, I62V, L63P, H69Y, I72EB
Holguin (2005)0002592402_25924AY248411None   M36L, N37S, R41K, I62V, L63P, I93LB
Rhee (2005)CA2205CA9809AY796897None   M36L, N37A, I62V, L63P, I64V, I72VB
 CA8453CA21438AY797767None   E35D, M36L, L63PB
 CA16097CA38320AY798170None   I15V, L19I, M36L, N37S, R57K, L63A, I72VB
Vazquez de Parga (2005)RU01035RU01035EU345742None   T12P, L19I, M36L, I62V, L63P, G68D, H69I, L89M, I93LB
Chin (2006)KRC43254325_0408DQ660447None   I15V, M36L, N37S, L63T, I64VB
 KRC43604360_0407DQ660452None   T12A, I15V, M36L, N37S, L63T, I64VB
 KRC23492349_0211DQ660484None   I15V, M36L, N37S, L63T, I64VB
 KRC22002200_0209DQ660488None   G16E, M36L, N37S, I62V, L63AB
 KRC50205020_0501DQ660491None   I15V, M36L, N37S, I62V, L63T, I64VB
Jayaraman (2006)2-00-06262-00-0626 None   K14R, L19I, M36L, I62V, L63CB
Lama (2006)Pt50055005 None   L10V, E35E_TN, M36L, L63A, L89MB
Andresen (2007)PMVL 027PMVL 027EF514698None   M36L, N37T, R57K, L63PB
Brumme (2007)1221PR_1221EF368531None   I15V, E35D, M36L, N37D, P39Q, R41K, D60E, I62V, L63PB
 1704PRRT_1704EF369014None   L10I, M36L, I62V, L63AS, I64IV, I72V, I93LB
 1798PRRT_1798EF369108None   L10I, K20R, E35D, M36L, N37D, L63P, I93LB
Dilernia (2007)N84N84EF120335None   I15V, G16E, K20R, M36L, N37S, V75I, I93LB
 N05N05EF120354None   T12S, I15V, L19I, M36L, N37S, I62V, L63PB
Gonsalez (2007)09HIV_09GU288739None   I15V, E35D, M36L, R41K, R57K, L63P, I93LB
 35HIV_35GU288779None   E35D, M36L, Q61H, I62V, L63P, H69Q, I72TB
 87HIV_87GU288751None   I13V, I15V, M36L, N37A, R57K, I62V, L63P, H69KB
Lin (2007)4V764V76EF078237None   Q7R, I13V, M36L, P39S, R41K, P44S, K45T, R57K, I62V, L63P, C67F, H69Y, K70N, T74A, N83I, Q92H, F99YB
Vicenti (2007)LR_9735052REF376607None   L19T, M36L, N37ST, I62V, L63LP, H69Y, I72MB
von Wyl (2007)1337207282EF449931None   I15V, M36L, N37T, I62V, I64VB
  1475858EF449885None   I15V, M36L, N37AT, R41RG, Q58QR, I62V, L63PQ, I64VB
Bang (2008)078BJH_078EF157934None   I15V, M36L, N37S, L63T, I72TB
 080BJH_080EF157936None   I3V, I15V, M36L, L63P, I64VB
Chang (2008)TW8477aTW8477a None   Q7X, I13V, E35E_E, M36L, R41K, R57K, I62V, L63PB
Ibe (2008)362362AB356353None   L10I, I15V, M36L, N37S, I62V, L63A, I93LB
 454454AB356419None   T12S, I15IV, L19LI, M36L, N37NSB
 531531AB356466None   L10I, I15V, M36L, N37S, I62V, L63A, I93LB
 567567AB356491None   Q7QH, L10I, I15V, M36L, N37NS, I62V, L63A, I93LB
McConnell (2008)NV55NV55EU288140None   V11M, T12S, L19I, M36L, N37S, L63C, I64VB
Miura (2008)BEC53BEC53EU517916None   L19LI, M36L, R41K, D60E, I62IV, L63P, Q92TB
Brown (2009)CAS_11_1_5767CAS_11_1_5767FJ030653None   G16E, M36L, G40GR, R41K, R57K, I62V, A71T, I93LB
Brumme (2009)F8505F8505GQ371880None   T12A, I15V, G16E, M36L, R41K, I62V, L63HB
 P5594P5594GQ372088None   M36L, I62V, L63P, I64LB
 W1506W1506GQ372222None   M36L, N37S, R41RK, I62V, L63LHQ, I64VB
Cardoso (2009)BRGO3050BRGO3050FJ594127None   I15V, M36L, I62V, L63Q, I64V, C67SB
Cuevas (2009)P1328P1328.1EU822631None   I13V, M36L, I62V, L63P, I72M, V75IB
 P1714P1714.1EU822755None   L10I, I13V, G16E, M36L, I72RB
Dumans (2009)13_0513_05FJ405053None   I15V, E35D, M36L, R41K, K45R, L63P, K70R, I93LB
 451_05451_05FJ405054None   I15V, E35D, M36L, R41K, K45R, L63P, K70R, I93LB
Fujisaki (2009)457457AB442253None   L10I, I15V, M36L, N37S, I62V, L63A, I93LB
 587587AB442258None   L10I, I15V, M36L, N37S, I62V, L63A, H69HY, I93LB
 608608AB442274None   L10I, T12P, I15V, M36L, N37S, R41RK, I62V, L63V, I64V, I93LB
 657657AB442318None   L10V, I15V, L19I, M36L, N37S, I62V, L63A, I93LB
Rhee (2009)CA8363CA24546FJ983277None   I15V, K20KM, M36L, N37S, I62V, I64VB
Smith (2009)PI56US1997PI56 None   M36L, R57K, L63PB
 PI149US2004PI149 None   I15IV, M36L, N37T, P39PS, R57K, I62IMV, L63P, I72IVB
 PI170US2004PI170 None   I15V, M36L, N37T, R57K, L63PB
 PI180US2003PI180 None   M36L, N37S, R41K, D60E, I62V, L63PB
 PI196US2005PI196 None   I15V, M36L, N37IT, R57K, L63P, I72VB
 PI227US2005PI227 None   I15V, M36L, N37T, R57K, L63P, I72VB
 PI286US2005PI286 None   M36L, N37T, R57K, I62V, L63PB
 PI344US2005PI344 None   Q2QR, I15V, M36L, N37T, R57K, L63P, I72V, I93LB
 CR80US2006CR80 None   M36L, N37T, R57K, L63PB
 CR128US2006CR128 None   T12TK, I15V, L19I, E35ED, M36L, N37NS, R41K, I62V, L63P, T74AB
 CR129US2006CR129 None   K20R, E35D, M36L, N37D, I62V, L63S, I64V, I72VB
 CR144US2006CR144 None   M36L, I62V, L63PB
 CR147US2006CR147 None   M36L, I62V, L63P, C67CYB
 CR172US2006CR172 None   T12TA, I15V, M36L, N37T, P39PS, R57K, I62IMV, L63P, I72IVB
 CR233US2007CR233 None   I13V, M36L, N37S, R57K, L63PB
 CR251US2006CR251 None   T4TP, I15IV, K20KE, M36L, N37T, R57K, L63P, I72IV, V77VIB
 CR262US2006CR262 None   M36L, N37T, R57K, L63P, R87RKB
 CR267US2006CR267 None   K14R, M36L, N37T, R41RK, R57K, L63PB
Vercauteren (2009)pt2097738438876GQ398927None   T12TA, M36L, R41K, R57K, L63P, I93LB
 pt20361089109740GQ398988None   I15V, K20R, M36L, R41K, R57K, I62IV, L63LP, V77I, I93LB
 pt19631507603441GQ399061None   I13V, I15V, L19V, M36L, R57K, D60E, I62V, L63PB
 pt18841987543711GQ399140None   I15V, M36L, R41K, R57K, L63P, V77I, I93LB
 pt18362279348359GQ399188None   I13V, K14R, M36L, N37D, R41K, I62IV, L63P, I72IT, V82IB
 pt14204750105544GQ399604None   K20R, M36L, I62V, L63P, A71TB
 pt14044823298120GQ399620None   I13IV, K14KR, M36L, R41K, R57K, L63P, A71AV, V77I, I93LB
 pt13924899209107GQ399632None   K20R, M36L, I62V, L63P, A71TB
 pt12675604452481GQ399757None   M36L, R41K, R57K, L63P, V77I, I93LB
 pt12655612058831GQ399759None   L10I, I13V, M36L, N37NS, R57RK, I62IV, L63LP, I64V, A71AV, I93LB
 pt11576246480820GQ399867None   M36L, N37S, R41K, R57K, L63P, A71V, V77I, I93LB
 pt10876678219891GQ399937None   K20R, M36L, I62V, L63P, A71TB
 pt6139329543392GQ400411None   I15IV, M36L, N37D, I62V, L63P, I93LB
 pt412f06HkNauLAGQ400612None   M36L, N37S, I62V, L63LFPS, I64IVB
Wang (2009)SH8183SH8183FJ469768None   T12P, L19I, M36L, N37S, L63P, A71V, V77I, I93LB
Arruda (2010)106716CE091067JQ230660None   L19V, M36L, N37S, K43R, R57K, I62V, L63P, I72LB
 110816CE091108RJQ230686None   L19V, M36L, N37S, K43R, R57K, I62V, L63P, I72LB
Brennan (2010)Pat102ARC-A131JN697277None   G17GE, M36L, N37S, G40GE, R41K, I62V, L63H, I64VB
 Pat052ARC-A185JN697327None   L33V, M36L, N37A, L63P, I64VB
Ragonnet-Cronin (2010)PHAC_347PHAC_347HM468845None   E35D, M36L, N37D, Q61Q*, L63PB
 PHAC_404PHAC_404HM468902None   T12S, L19I, L33V, M36L, N37S, I64VB
 PHAC_535PHAC_535HM469033None   K14R, L19I, M36L, I62V, L63CB
 PHAC_556PHAC_556HM469054None   K14R, L19I, M36L, I62V, L63CB
 PHAC_597PHAC_597HM469095None   M36L, N37S, I62IV, L63C, L89MB
 PHAC_777PHAC_777HM469275None   K14R, L19I, M36L, I62V, L63CB
Yebra (2010)22414705SP0224147FJ481785None   T12P, L19I, E35D, M36L, N37D, R57K, I62V, L63I, E65D, A71V, I72T, I93LB
 32146906SP0321469FJ481848None   M36L, N37AGST, L63P, I64VB
Chibo (2011)S79S79JF895266None   T12A, L19I, M36L, N37S, I62V, L63Q, I64VB
de Medeiros (2011)Pat029RS101JF487858None  V32E, I84LQ7E, E21G, E35N, M36L, N37S, R41K, L89MB
Ferreira (2011)BRMT2864BRMT2864HQ638733None   I13V, M36L, N37S, Q61H, L63P, H69Q, K70E, A71V, T91A, Q92KB
 BRMT3056BRMT3056HQ638740None   M36L, N37S, K45R, I62V, L63S, I64V, H69Q, K70E, A71V, T91A, Q92KB
 BRMT521BRMT521HQ638762None   M36L, N37S, K45R, I62V, L63P, I64M, H69Q, K70E, A71V, T91A, Q92KB
 BRMT522BRMT522HQ638763None   I15V, K20KR, M36L, R41K, R57K, I62IV, L63P, I93LB
 BRMT1238BRMT1238HQ638780None   I13V, K20R, M36L, D60E, Q61E, I62V, L63LP, I64VB
Truong (2011)0500310105003101 None   I13V, M36L, N37D, L63P, I72IVB
 0700003907000039 None   M36L, N37C, R57K, L63P, I64VB
 0600148406001484 None   I15V, M36L, I62V, I64L, H69Y, A71V, I72T, I93LB
 0500148105001481 None   I15V, M36L, I62V, H69Y, A71V, I72T, I93LB
 0500184105001841 None   I15V, M36L, I62V, H69Y, A71V, I72T, I93LB
Avila-Rios (2012)JC00MC6GRUJC00MC6GRUKC169104None   T4P, K14R, E35D, M36L, N37D, R41K, L63P, I72IVB
 JV00MEEOR0JV00MEEOR0KC169146None   G16A, M36L, N37S, I62V, L63S, I64V, V77I, I93LB
 M000M95GTDM000M95GTDKC169195None   I15V, M36L, N37S, V56LB
 J000MG1TQLJ000MG1TQLKC168987None   M36L, N37S, I62V, L63P, L89MB
da Silveira (2012)BRMS03_10BRMS03_10JF342314None   T12K, I15IV, L19IV, M36L, N37S, P39PS, R57K, L63P, I64VB
De Gascun (2012)IRL41729IRL41729JN622591None   I15V, L19I, K20R, E35D, M36L, N37D, L63S, Q92KB
 IRL23656IRL23656JN622642None   T12TP, E35D, M36L, N37E, I62V, L63IT, H69K, A71T, I93LB
 IRL42604IRL42604JN622684None   I15V, G16A, M36L, N37T, I62VB
Delwart (2012)477-3983-6477-3983-6JN214988None   I13V, I15V, L19I, M36L, I62V, L63T, I64L, K70R, I72TB
 478-4822-3478-4822-3JN215022None   I13V, L19I, M36L, N37H, L63PB
 479-9378-9479-9378-9JN215069None   M36L, L63S, E65D, I72V, V77IB
Gaspareto (2012)LBS41LBS41PTHM752172None   T4S, T12K, I15V, M36L, R41K, Q61N, I62V, L63V, I64M, E65DB
Mollan (2012)MK140MK140w66 None   I15V, M36L, N37S, I62V, L63A, K70RB
 MK95MK95w0 None   L10V, T12P, G16E, M36L, N37S, L63AT, I93LB
Ragonnet-Cronin (2012)A10_030A10_030JX014692None   L10V, I15V, M36L, N37S, R41RK, L63T, I72TB
 A10_175A10_175JX014749None   L10V, I15V, G16E, M36L, L63T, I72TB
 A10_187A10_187JX014756None   L10I, I15V, M36L, N37S, L63T, I72T, L89M, I93LB
 A10_254A10_254JX014782None   L10V, I15V, M36L, N37S, L63T, I72TB
 A10_370A10_370JX014826None   L10I, I15V, M36L, N37S, R41K, D60E, L63T, I72T, I93LB
 B07_388B07_388JX014945None   E35D, M36L, N37D, R57RK, I62V, L63S, I64ILM, A71V, I93LB
Ragonnet-Cronin (2012)PHAC08_084PHAC08_084JQ674820None   L10I, T12K, M36L, N37D, R41RK, L63P, I93LB
 PHAC08_089PHAC08_089JQ674822None   I15V, E35EG, M36L, N37X, I62V, L63P, A71T, I72E, V77I, I93LB
 PHAC08_149PHAC08_149JQ674837None   K14R, L19I, M36L, I62V, L63C, I72ITB
 PHAC09_099PHAC09_099JQ674916None   M36L, N37T, D60E, Q61E, I62V, I64V, I72VB
 PHAC09_104PHAC09_104JQ674918None   L10I, K20R, E35DN, M36L, N37D, L63P, A71T, I93LB
 PHAC08_114PHAC08_114JQ675086None   I15IV, M36L, N37T, R41RK, D60E, Q61E, I62V, I64V, I72VB
 PHAC08_136PHAC08_136JQ675098None   I15V, M36L, N37A, D60E, Q61E, I62V, L63PB
 PHAC08_151PHAC08_151JQ675103None   L10I, M36L, N37D, L63PS, I93LB
 PHAC08_254PHAC08_254JQ675159None   L10I, I15V, M36L, N37S, L63T, I72T, I93LB
 PHAC08_280PHAC08_280JQ675177None   L10I, T12K, M36L, N37D, R57RK, L63P, I93LB
 PHAC08_287PHAC08_287JQ675182None   L10I, T12P, I15V, G16GE, E35D, M36L, N37D, P39Q, Q61DN, I62V, L63AT, I93LB
 PHAC08_302PHAC08_302JQ675189None   I15V, M36L, R41K, I62V, I64IV, A71T, I72V, V77VI, I93LB
 PHAC08_310PHAC08_310JQ675191None   L10I, I15V, M36L, N37S, R41RK, L63T, I72T, I93LB
 PHAC09_161PHAC09_161JQ675260None   M36L, N37E, R57K, I62V, L63P, A71V, I93LB
Zeng (2012)CN0955CN0955JQ028277None   L33V, E35D, M36L, R41K, D60E, L63P, L89P, I93LB
Alencar (2013)RJ2-0024RJ2-0024JQ237946None   I15V, M36L, N37T, I62V, L63P, I72TB
 MG2-0018MG2-0018JQ238018None   T12P, K14R, L19I, M36L, L63P, C67Y, A71V, I72V, V77I, I93LB
 PE2-0039PE2-0039JQ238030None   I15V, M36L, N37S, I62V, L63P, H69HQ, I72ITB
 PE2-0040PE2-0040JQ238054None   I15V, M36L, N37S, I62V, L63P, I72TB
 PE2-0091PE2-0091JQ238158None   L10V, I13V, M36L, R41K, D60E, L63P, I64VB
 RJ2-0105RJ2-0105JQ238217None   K14R, I15V, L19T, M36L, N37SB
Brooks (2013)CAN2013-225CAN13-225KF727923None   I15V, E34ED, E35ED, M36L, N37NT, R41K, I62V, L63C, I93LB
 CAN2013-025CAN13-025KF727830None  L33IL10I, I15L, L19I, M36L, N37E, R41K, K45R, D60E, I62V, L63S, I64V, A71T, I93LB
Ferreira (2013)BR09SP205BR09SP205HM534120None   Q2QP, T12P, L19LI, M36L, N37E, D60E, I62V, L63P, I64V, I93LB
Frentz (2013)EHR-11420EHR-11420JX299721None   I13V, I15V, L19I, K20R, M36L, N37S, R57K, L63S, I64V, V75VIB
 EHR-149859EHR-149859JX299788None   M36L, N37S, L63S, A71V, I72T, V77I, I93LB
 EHR-16230EHR-16230JX299811None   M36L, N37S, L63S, A71V, I72T, V77I, I93LB
 EHR-33768EHR-33768JX300112None   L10I, M36L, N37S, I62V, L63S, I64V, I93LB
 EHR-38665EHR-38665JX300189None   L10I, M36L, N37S, I62V, L63S, I64V, I93LB
 EHR-48968EHR-48968JX300353None   T12P, L19I, M36L, N37S, R41RK, Q61QHKN, L63S, I64V, E65D, I93ILB
 EHR-59489EHR-59489JX300532None   M36L, N37T, I62V, L63S, I64VB
Han (2013)LC013ILC013IJX070480None   M36L, N37S, R41K, L63P, H69KB
Kiertiburanakul (2013)R71103R71103KC921824None   M36L, N37S, R57K, Q61E, L63P, A71V, I93LB
 R72244R72244KC857065None   T12R, L19I, M36L, I62V, L63P, K70Q, V77IB
Smolen-Dzirba (2013)MB6533MB6533JN811587None   T12P, L19I, M36L, N37S, R41K, Q61N, L63S, I64V, E65DB
 MRS7272MRS7272JN811617None   T12P, L19T, M36L, N37S, R41K, Q61N, L63S, I64V, E65DB
Wu (2013)HFP102HFP102KC203237None   L19LFI, E35D, M36L, N37D, R41K, D60E, L63P, I93LB