<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation E35N
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 53
Isolates 58
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gonzales (2001)CA4159CA9986AY031136IDV, NFV111D30NN88DQ2QH, I13V, L19I, K20I, E35N, M36I, N37D, D60E, Q61E, L63P, A71V, I72TB
Tural (2002)880801880801 Unknown, IDV, NFV>94  E35N, N37D, R41K, L63P, I93LB
Gonzales (2003)CA1317CA1317-5/3AY798450IDV, SQV, RTV, LPV, Unknown>235M46I, I54V, L90ML10F, N88GI13L, I15V, K20T, E35N, M36I, R41K, R57K, I62V, L63P, C67Y, A71I, I93LB
Shafer (2003)A384_09010901d NFV, RTV, APV160I54L, I84V, L90ML33F, N83DL10I, K20R, E35N, M36L, N37D, I62V, L63P, A71V, L89IB
Wu (2003)CA6800CA21370AF544598SQV, RTV, APV, IDV, LPV221M46L, I84VL33F, N83DT4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89IB
Gomez-Carrillo (2004)105783105783AY365736PINAM46ML, I54V, V82F, L90M L10I, K20I, E35N, M36I, N37D, R41K, D60E, L63P, A71V, I85V, I93LB
 109115109115AY365806PINAD30NN88DT12N, L19I, K20T, E35N, M36I, R57K, D60DE, Q61DG, A71VB
 110666110666AY365840PINAM46I, I54A, V82A, L90ML10FI, K43T, L89VI13V, I15V, K20I, E35N, M36I, N37E, K55R, R57K, Q61N, I62V, L63P, A71V, T74S, Q92KB
Rhee (2005)CA4159CA33556AY797026IDV, NFV, SQV, RTV265D30N, I54V, L90ML10LF, V11I, F53L, Q58E, N88DI13V, L19I, K20I, E35N, M36I, N37DE, D60E, Q61E, L63P, A71V, I72TB
 CA6800CA17091AY797445SQV, RTV, APV, IDV183I84VL33FL10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, C67CW, V77I, I85XB
  CA21302AY797446SQV, RTV, APV, IDV, LPV217M46L, I84VL33F, N83DT4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89IB
Baxter (2006)12-20052005-30630DQ875999PINAM46I, I54V, I84V, L90ML10F, V11I, G73TK14R, I15V, K20I, L24M, E35N, M36I, R41K, I62V, L63P, A71V, I85V, I93LB
 12-40254025-30616DQ876139PINAM46I, I47V, I54V, I84V, L90ML10F, V11I, Q58E, G73SI13V, I15V, K20I, E35N, M36I, N37D, K55R, D60E, Q61E, I62V, L63P, A71IT, I72T, I93LB
 12-17051705-30409DQ876291PINAM46I, I54M, I84V, L90ML10F, L33F, G73S, L89VI13V, I15V, L19I, K20V, E35N, M36I, N37T, R41K, I62V, L63P, I66F, A71V, P79AB
 12-17081708-30513DQ876294PINAM46L, I54M, V82A, L90ML10FV, L33F, K43T, G73SI13V, I15V, K20T, E35N, M36I, N37D, K55R, D60E, I62V, L63E, A71V, V77IB
 12-20282028-30723DQ876339PINAM46I, I54V, V82A, L90ML24I, L33I, Q58EL10I, I13V, K20M, E35N, M36I, R41RK, K55R, R57RK, D60E, I62IV, L63E, I64V, A71T, V75I, T91AB
 12-10741074-30313DQ876397PINAI84V, L90MG73GSL10I, T12K, I13V, I15V, K20I, E35N, M36I, N37E, R57K, D60E, I62V, L63P, A71T, I72V, P79AB
 12-22112211-30819DQ876440PINAM46I, I50V, I54V, L90MG73T, L89VT4S, L10I, K20I, E35N, M36I, P44PL, D60E, I62V, L63P, K70T, A71V, I72LB
 12-19131913-30515DQ876762PINAD30N, I54LV, V82A, L90ML10F, L33F, N88DI15V, K20V, E35N, M36I, R41K, I62V, L63P, K70N, A71V, I72VB
 12-14691469-30422DQ876874PINAI54IV, V82A, L90MV11IL, L33F, F53LL10I, I15V, K20V, L24F, E35N, M36I, R41K, K45KR, K55KR, D60E, I62V, L63P, A71I, I85IV, L89LIMB
 12-19501950-30602DQ876915PINAI84V, L90MG73SL10I, I15V, K20I, E35N, M36I, N37H, R41K, I62V, L63P, A71V, P79HNB
 12-15551555-30625DQ877058PINAV32I, M46I, I47V, I54L, L90ML10FK20I, E35N, M36I, N37D, K55R, R57RK, I62V, L63P, I66F, C67Y, A71T, I72LB
 12-12561256-30520DQ877121PINAM46L, I54V, V82AL10F, L24I, L33F, K43T, G73CI15V, K20MT, E35N, M36I, N37D, K55R, R57K, D60E, Q61R, I62V, L63P, A71V, I72EB
 12-30603060-30415DQ877165PINAM46I, I84V, L90ML10F, L33F, N83D, N88DT4S, I13V, G16A, L19I, L24L*, E35N, M36I, P39S, I62V, L63P, A71V, I72VB
 12-31003100-30521DQ877248PINAM46I, V82AL10F, L24I, K43T, I54CL19I, K20M, E35N, M36L, N37D, L38W, K55R, R57K, D60E, I62V, L63P, I64V, A71V, I93LB
 48-10101010-30611DQ877318PINAV32I, I47V, I54M, L90ML10F, L33F, L89VK14R, I15V, K20T, E35N, M36I, R41Q, A71V, I72T, G73D, I85V, I93LB
 48-30933093-30401DQ878000PINAM46I, I54M, L90ML10F, L33F, Q58E, G73S, L89VK20V, E35N, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, A71V, I72T, I85V, I93LB
 48-31403140-30414DQ878051PINAD30N, I54L, L90ML33I, N88DL10I, K20R, E35N, M36I, I62V, L63P, A71T, I85V, I93LB
 48-31593159-30402DQ878068PINAI50V, I54V, V82AL10F, F53LK14R, I15V, L19P, K20I, E35N, M36I, N37D, R41T, K45V, I62V, I64V, A71V, I85V, L89IB
 48-31663166-30424DQ878075PINAM46I, I54V, L76VL24I, Q58EL10V, I15V, K20V, E35N, M36I, K55KR, R57K, D60E, I62V, L63P, I64V, I72V, V82IB
 48-32543254-30610DQ878158PINAV32I, M46I, I47A, L90ML23I, F53FLL10I, I15V, K20T, E35N, M36I, N37D, I62V, L63P, I66IV, A71L, I72V, V77I, I93LB
 48-32613261-30728DQ878165PINAI54V, V82FK43T, T74PL10I, I13V, I15V, L19I, K20T, E35N, M36I, N37S, I62V, L63V, I64VB
 48-32743274-30729DQ878179PINAM46I, I47V, I54V, V82F, L90MF53LL10I, I13V, K20I, E35N, M36I, N37S, R41E, D60E, L63P, I64V, A71V, V77I, I93LB
 48-42954295-30722DQ878517PINAM46L, I54V, I84V, L90ML10F, V11I, L33F, T74PI13V, K20T, E35N, M36I, N37D, K55R, I62V, L63P, A71V, T91S, C95C*B
 48-43034303-30815DQ878521PINAM46I, I54V, I84V, L90ML10FI, Q58QE, G73TV11VL, I13V, K20I, E35N, M36I, N37D, K55R, D60E, I62IV, L63P, I64V, A71AITV, I72KB
 48-50725072-30807DQ878582PINAM46I, I47V, I54V, V82A, L90ML10F, L33I, Q58E, L89VI13V, K20M, E35N, M36I, N37D, K55R, D60E, Q61E, I62V, L63P, A71T, I72T, Q92QRB
 48-50805080-30903DQ878590PINAG48V, I54V, V82SL24I, Q58EL10I, K20M, E35N, M36V, N37D, D60E, Q61QE, I62V, L63P, I64V, I85VB
 48-60256025-30407DQ878624PINAM46L, I54L, V82A, L90ML33F, T74PSL10I, I13V, K20X, E35N, M36I, I62V, L63P, A71V, I85IV, I93LB
 48-60446044-30507DQ878643PINAM46I, I47V, I54V, V82A, L90ML33I, L89VL10I, I13A, K20M, A22V, E35N, M36I, R41K, R57K, D60E, I62V, L63P, A71T, I72M, T74E, Q92KB
 48-60506050-30529DQ878649PINAM46I, I50V, I54V, V82A, L90MV11I, Q58E, G73S, L89VL10I, I15V, L19Q, K20I, E35N, M36I, K55R, I62V, L63P, A71V, I72V, I85VB
 48-63446344-30918DQ878867PINAM46I, I47IV, I54IL, L76LV, I84V, L90ML10FI, L33I, N83D, L89VI13V, Q18H, A22V, E35N, M36I, N37D, R41RK, K55KR, I62V, L63P, A71VB
 48-90289028-30825DQ877497PINAM46I, I47V, I54V, V82FQ58EL10I, K20I, E35N, M36I, N37D, I62V, L63T, I72T, V77I, I85V, L89MB
 48-90439043-30925DQ877736PINAM46I, I50V, I54V, V82A, L90MK43TL10I, T12N, I15V, L19Q, K20M, E35N, M36I, R41K, K55R, I62V, L63P, A71V, T74SB
 48-80218021-30806DQ879064PINAM46I, I47V, I54M, I84V, L90ML10F, K43T, G73S, L89VV11L, T12N, I15V, L19LP, K20I, E35N, M36I, N37E, I62V, L63P, A71I, I72KR, V77I, I85V, I93LB
Rhee (2006)CA17654CA63815 Unknown, NFV, IDV, LPV>142I54V, V82A, L90MV11I, Q58E, G73SL10I, K14R, I15V, L19LP, K20I, E35N, M36I, R57K, I62V, L63P, A71V, I72ILB
Cardoso (2009)3006BRGO3006FJ618910PINAD30N, I54LL10F, L33I, N88DT12S, K14R, L19V, K20T, E35N, M36I, N37S, R41K, L63P, A71T, I85V, I93LB
Dau (2010)06566A06566AGU581761PINAM46I, I54V, V82F, I84V, L90MF53LL10I, I13V, K20I, E35N, M36I, N37S, D60E, L63P, A71V, I93MB
Rhee (2010)CA1317CA71566 IDV, SQV, RTV, LPV, Unknown>235M46I, I54V, L90ML10F, V11I, L33LI, N88GI13L, I15V, K20T, E35N, M36I, N37D, R41K, V56A, R57K, Y59YH, I62V, L63P, C67Y, A71L, I93LB
 CA4159CA87351 IDV, NFV, SQV, RTV, APV, LPV522D30N, I54IV, L90MV11VI, F53FL, Q58QE, N83ND, N88DT12TA, I13IV, L19I, K20I, E35N, M36I, N37DE, D60E, Q61E, L63P, A71V, I72TB
Jones (2012)129964129964JN669478PINAD30NL10F, N88DG17E, K20T, E35N, M36I, D60E, Q61D, L63P, I72VB
 152142152142JN669774PINAM46I, I47V, I54V, I84V, L90MV11I, L33I, G73S, L89VL10Y, I13V, I15V, G17D, Q18H, K20V, E35N, M36I, N37E, K55R, R57RK, D60E, I62V, L63P, A71V, I72T, I85V, R87RG, I93LB
 152995152995JN669792PINAM46I, I54L, L90M L10R, I13V, K20V, E35N, M36I, K55R, D60E, I62V, L63P, I64VB
 157470157470JN669886PINAM46I, I47V, I54V, I84V, L90MV11I, L33I, G73S, L89VL10Y, I13V, I15V, G17D, Q18H, K20V, E35N, M36I, N37E, K55R, R57K, D60E, I62V, L63P, A71V, I72T, I85V, I93LB
 157481157481JN669887PINA  I15V, G16E, K20M, E35N, M36I, R41K, R57RK, Q61N, I72T, I93LB
 161316161316JN670001PINAM46I, L90MN88DL10V, I13V, I15V, Q18LM, L19I, K20T, E35N, M36I, R41K, K55R, R57K, Q61D, L63PB
 188852188852JN670760PINAD30N, I54V, L90ML10F, V11VI, L33I, Q58E, N88DT12N, I13V, L19M, K20T, E35N, M36I, N37S, P39Q, R57K, D60DN, Q61QHKN, I62IV, L63P, A71T, I72IMB
 193453193453JN670899PINAM46I, I47V, I54V, V82AL10F, K43T, N88DI15V, L19IT, K20I, E35N, M36I, R41RK, R57K, D60E, Q61N, I62IV, L63P, A71V, I85IVB
 195200195200JN670969PINAM46I, I54A, V82F, L90M L10V, T12P, I13V, I15V, Q18H, K20T, E35N, M36I, N37S, L63P, I64V, A71V, T74S, V77I, L89I, I93LB