Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	E35N
Rx	>= 1 PI
IncludeMixtures	No

References	13
Patients	53
Isolates	58

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Gonzales (2001)	CA4159	CA9986	AY031136	IDV, NFV	111	D30N	N88D	Q2QH, I13V, L19I, K20I, E35N, M36I, N37D, D60E, Q61E, L63P, A71V, I72T	B
Tural (2002)	880801	880801		Unknown, IDV, NFV	>94			E35N, N37D, R41K, L63P, I93L	B
Gonzales (2003)	CA1317	CA1317-5/3	AY798450	IDV, SQV, RTV, LPV, Unknown	>235	M46I, I54V, L90M	L10F, N88G	I13L, I15V, K20T, E35N, M36I, R41K, R57K, I62V, L63P, C67Y, A71I, I93L	B
Shafer (2003)	A384_0901	0901d		NFV, RTV, APV	160	I54L, I84V, L90M	L33F, N83D	L10I, K20R, E35N, M36L, N37D, I62V, L63P, A71V, L89I	B
Wu (2003)	CA6800	CA21370	AF544598	SQV, RTV, APV, IDV, LPV	221	M46L, I84V	L33F, N83D	T4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89I	B
Gomez-Carrillo (2004)	105783	105783	AY365736	PI	NA	M46ML, I54V, V82F, L90M		L10I, K20I, E35N, M36I, N37D, R41K, D60E, L63P, A71V, I85V, I93L	B
	109115	109115	AY365806	PI	NA	D30N	N88D	T12N, L19I, K20T, E35N, M36I, R57K, D60DE, Q61DG, A71V	B
	110666	110666	AY365840	PI	NA	M46I, I54A, V82A, L90M	L10FI, K43T, L89V	I13V, I15V, K20I, E35N, M36I, N37E, K55R, R57K, Q61N, I62V, L63P, A71V, T74S, Q92K	B
Rhee (2005)	CA4159	CA33556	AY797026	IDV, NFV, SQV, RTV	265	D30N, I54V, L90M	L10LF, V11I, F53L, Q58E, N88D	I13V, L19I, K20I, E35N, M36I, N37DE, D60E, Q61E, L63P, A71V, I72T	B
	CA6800	CA17091	AY797445	SQV, RTV, APV, IDV	183	I84V	L33F	L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, C67CW, V77I, I85X	B
		CA21302	AY797446	SQV, RTV, APV, IDV, LPV	217	M46L, I84V	L33F, N83D	T4P, L10V, K20R, E35N, M36I, N37T, F53I, R57K, I62V, L63P, T74A, I85V, L89I	B
Baxter (2006)	12-2005	2005-30630	DQ875999	PI	NA	M46I, I54V, I84V, L90M	L10F, V11I, G73T	K14R, I15V, K20I, L24M, E35N, M36I, R41K, I62V, L63P, A71V, I85V, I93L	B
	12-4025	4025-30616	DQ876139	PI	NA	M46I, I47V, I54V, I84V, L90M	L10F, V11I, Q58E, G73S	I13V, I15V, K20I, E35N, M36I, N37D, K55R, D60E, Q61E, I62V, L63P, A71IT, I72T, I93L	B
	12-1705	1705-30409	DQ876291	PI	NA	M46I, I54M, I84V, L90M	L10F, L33F, G73S, L89V	I13V, I15V, L19I, K20V, E35N, M36I, N37T, R41K, I62V, L63P, I66F, A71V, P79A	B
	12-1708	1708-30513	DQ876294	PI	NA	M46L, I54M, V82A, L90M	L10FV, L33F, K43T, G73S	I13V, I15V, K20T, E35N, M36I, N37D, K55R, D60E, I62V, L63E, A71V, V77I	B
	12-2028	2028-30723	DQ876339	PI	NA	M46I, I54V, V82A, L90M	L24I, L33I, Q58E	L10I, I13V, K20M, E35N, M36I, R41RK, K55R, R57RK, D60E, I62IV, L63E, I64V, A71T, V75I, T91A	B
	12-1074	1074-30313	DQ876397	PI	NA	I84V, L90M	G73GS	L10I, T12K, I13V, I15V, K20I, E35N, M36I, N37E, R57K, D60E, I62V, L63P, A71T, I72V, P79A	B
	12-2211	2211-30819	DQ876440	PI	NA	M46I, I50V, I54V, L90M	G73T, L89V	T4S, L10I, K20I, E35N, M36I, P44PL, D60E, I62V, L63P, K70T, A71V, I72L	B
	12-1913	1913-30515	DQ876762	PI	NA	D30N, I54LV, V82A, L90M	L10F, L33F, N88D	I15V, K20V, E35N, M36I, R41K, I62V, L63P, K70N, A71V, I72V	B
	12-1469	1469-30422	DQ876874	PI	NA	I54IV, V82A, L90M	V11IL, L33F, F53L	L10I, I15V, K20V, L24F, E35N, M36I, R41K, K45KR, K55KR, D60E, I62V, L63P, A71I, I85IV, L89LIM	B
	12-1950	1950-30602	DQ876915	PI	NA	I84V, L90M	G73S	L10I, I15V, K20I, E35N, M36I, N37H, R41K, I62V, L63P, A71V, P79HN	B
	12-1555	1555-30625	DQ877058	PI	NA	V32I, M46I, I47V, I54L, L90M	L10F	K20I, E35N, M36I, N37D, K55R, R57RK, I62V, L63P, I66F, C67Y, A71T, I72L	B
	12-1256	1256-30520	DQ877121	PI	NA	M46L, I54V, V82A	L10F, L24I, L33F, K43T, G73C	I15V, K20MT, E35N, M36I, N37D, K55R, R57K, D60E, Q61R, I62V, L63P, A71V, I72E	B
	12-3060	3060-30415	DQ877165	PI	NA	M46I, I84V, L90M	L10F, L33F, N83D, N88D	T4S, I13V, G16A, L19I, L24L*, E35N, M36I, P39S, I62V, L63P, A71V, I72V	B
	12-3100	3100-30521	DQ877248	PI	NA	M46I, V82A	L10F, L24I, K43T, I54C	L19I, K20M, E35N, M36L, N37D, L38W, K55R, R57K, D60E, I62V, L63P, I64V, A71V, I93L	B
	48-1010	1010-30611	DQ877318	PI	NA	V32I, I47V, I54M, L90M	L10F, L33F, L89V	K14R, I15V, K20T, E35N, M36I, R41Q, A71V, I72T, G73D, I85V, I93L	B
	48-3093	3093-30401	DQ878000	PI	NA	M46I, I54M, L90M	L10F, L33F, Q58E, G73S, L89V	K20V, E35N, M36I, R41K, K55R, D60E, Q61E, I62V, L63P, A71V, I72T, I85V, I93L	B
	48-3140	3140-30414	DQ878051	PI	NA	D30N, I54L, L90M	L33I, N88D	L10I, K20R, E35N, M36I, I62V, L63P, A71T, I85V, I93L	B
	48-3159	3159-30402	DQ878068	PI	NA	I50V, I54V, V82A	L10F, F53L	K14R, I15V, L19P, K20I, E35N, M36I, N37D, R41T, K45V, I62V, I64V, A71V, I85V, L89I	B
	48-3166	3166-30424	DQ878075	PI	NA	M46I, I54V, L76V	L24I, Q58E	L10V, I15V, K20V, E35N, M36I, K55KR, R57K, D60E, I62V, L63P, I64V, I72V, V82I	B
	48-3254	3254-30610	DQ878158	PI	NA	V32I, M46I, I47A, L90M	L23I, F53FL	L10I, I15V, K20T, E35N, M36I, N37D, I62V, L63P, I66IV, A71L, I72V, V77I, I93L	B
	48-3261	3261-30728	DQ878165	PI	NA	I54V, V82F	K43T, T74P	L10I, I13V, I15V, L19I, K20T, E35N, M36I, N37S, I62V, L63V, I64V	B
	48-3274	3274-30729	DQ878179	PI	NA	M46I, I47V, I54V, V82F, L90M	F53L	L10I, I13V, K20I, E35N, M36I, N37S, R41E, D60E, L63P, I64V, A71V, V77I, I93L	B
	48-4295	4295-30722	DQ878517	PI	NA	M46L, I54V, I84V, L90M	L10F, V11I, L33F, T74P	I13V, K20T, E35N, M36I, N37D, K55R, I62V, L63P, A71V, T91S, C95C*	B
	48-4303	4303-30815	DQ878521	PI	NA	M46I, I54V, I84V, L90M	L10FI, Q58QE, G73T	V11VL, I13V, K20I, E35N, M36I, N37D, K55R, D60E, I62IV, L63P, I64V, A71AITV, I72K	B
	48-5072	5072-30807	DQ878582	PI	NA	M46I, I47V, I54V, V82A, L90M	L10F, L33I, Q58E, L89V	I13V, K20M, E35N, M36I, N37D, K55R, D60E, Q61E, I62V, L63P, A71T, I72T, Q92QR	B
	48-5080	5080-30903	DQ878590	PI	NA	G48V, I54V, V82S	L24I, Q58E	L10I, K20M, E35N, M36V, N37D, D60E, Q61QE, I62V, L63P, I64V, I85V	B
	48-6025	6025-30407	DQ878624	PI	NA	M46L, I54L, V82A, L90M	L33F, T74PS	L10I, I13V, K20X, E35N, M36I, I62V, L63P, A71V, I85IV, I93L	B
	48-6044	6044-30507	DQ878643	PI	NA	M46I, I47V, I54V, V82A, L90M	L33I, L89V	L10I, I13A, K20M, A22V, E35N, M36I, R41K, R57K, D60E, I62V, L63P, A71T, I72M, T74E, Q92K	B
	48-6050	6050-30529	DQ878649	PI	NA	M46I, I50V, I54V, V82A, L90M	V11I, Q58E, G73S, L89V	L10I, I15V, L19Q, K20I, E35N, M36I, K55R, I62V, L63P, A71V, I72V, I85V	B
	48-6344	6344-30918	DQ878867	PI	NA	M46I, I47IV, I54IL, L76LV, I84V, L90M	L10FI, L33I, N83D, L89V	I13V, Q18H, A22V, E35N, M36I, N37D, R41RK, K55KR, I62V, L63P, A71V	B
	48-9028	9028-30825	DQ877497	PI	NA	M46I, I47V, I54V, V82F	Q58E	L10I, K20I, E35N, M36I, N37D, I62V, L63T, I72T, V77I, I85V, L89M	B
	48-9043	9043-30925	DQ877736	PI	NA	M46I, I50V, I54V, V82A, L90M	K43T	L10I, T12N, I15V, L19Q, K20M, E35N, M36I, R41K, K55R, I62V, L63P, A71V, T74S	B
	48-8021	8021-30806	DQ879064	PI	NA	M46I, I47V, I54M, I84V, L90M	L10F, K43T, G73S, L89V	V11L, T12N, I15V, L19LP, K20I, E35N, M36I, N37E, I62V, L63P, A71I, I72KR, V77I, I85V, I93L	B
Rhee (2006)	CA17654	CA63815		Unknown, NFV, IDV, LPV	>142	I54V, V82A, L90M	V11I, Q58E, G73S	L10I, K14R, I15V, L19LP, K20I, E35N, M36I, R57K, I62V, L63P, A71V, I72IL	B
Cardoso (2009)	3006	BRGO3006	FJ618910	PI	NA	D30N, I54L	L10F, L33I, N88D	T12S, K14R, L19V, K20T, E35N, M36I, N37S, R41K, L63P, A71T, I85V, I93L	B
Dau (2010)	06566A	06566A	GU581761	PI	NA	M46I, I54V, V82F, I84V, L90M	F53L	L10I, I13V, K20I, E35N, M36I, N37S, D60E, L63P, A71V, I93M	B
Rhee (2010)	CA1317	CA71566		IDV, SQV, RTV, LPV, Unknown	>235	M46I, I54V, L90M	L10F, V11I, L33LI, N88G	I13L, I15V, K20T, E35N, M36I, N37D, R41K, V56A, R57K, Y59YH, I62V, L63P, C67Y, A71L, I93L	B
	CA4159	CA87351		IDV, NFV, SQV, RTV, APV, LPV, FPV	522	D30N, I54IV, L90M	V11VI, F53FL, Q58QE, N83ND, N88D	T12TA, I13IV, L19I, K20I, E35N, M36I, N37DE, D60E, Q61E, L63P, A71V, I72T	B
Jones (2012)	129964	129964	JN669478	PI	NA	D30N	L10F, N88D	G17E, K20T, E35N, M36I, D60E, Q61D, L63P, I72V	B
	152142	152142	JN669774	PI	NA	M46I, I47V, I54V, I84V, L90M	V11I, L33I, G73S, L89V	L10Y, I13V, I15V, G17D, Q18H, K20V, E35N, M36I, N37E, K55R, R57RK, D60E, I62V, L63P, A71V, I72T, I85V, R87RG, I93L	B
	152995	152995	JN669792	PI	NA	M46I, I54L, L90M		L10R, I13V, K20V, E35N, M36I, K55R, D60E, I62V, L63P, I64V	B
	157470	157470	JN669886	PI	NA	M46I, I47V, I54V, I84V, L90M	V11I, L33I, G73S, L89V	L10Y, I13V, I15V, G17D, Q18H, K20V, E35N, M36I, N37E, K55R, R57K, D60E, I62V, L63P, A71V, I72T, I85V, I93L	B
	157481	157481	JN669887	PI	NA			I15V, G16E, K20M, E35N, M36I, R41K, R57RK, Q61N, I72T, I93L	B
	161316	161316	JN670001	PI	NA	M46I, L90M	N88D	L10V, I13V, I15V, Q18LM, L19I, K20T, E35N, M36I, R41K, K55R, R57K, Q61D, L63P	B
	188852	188852	JN670760	PI	NA	D30N, I54V, L90M	L10F, V11VI, L33I, Q58E, N88D	T12N, I13V, L19M, K20T, E35N, M36I, N37S, P39Q, R57K, D60DN, Q61QHKN, I62IV, L63P, A71T, I72IM	B
	193453	193453	JN670899	PI	NA	M46I, I47V, I54V, V82A	L10F, K43T, N88D	I15V, L19IT, K20I, E35N, M36I, R41RK, R57K, D60E, Q61N, I62IV, L63P, A71V, I85IV	B
	195200	195200	JN670969	PI	NA	M46I, I54A, V82F, L90M		L10V, T12P, I13V, I15V, Q18H, K20T, E35N, M36I, N37S, L63P, I64V, A71V, T74S, V77I, L89I, I93L	B

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