<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation E35G
Rx >= 1 PI
IncludeMixtures No
References 21
Patients 54
Isolates 68
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Winters (1997)KA00116251162528862 NFV138D30NN88DI3V, L10I, E35G, M36I, R41K, L63P, I93LB
Winters (1998)MW-ins14jci-14AF096894PINAI54V, I84V, L90MG73SI15V, L19P, K20I, E35G, M36I, I62V, L63P, A71XB
Baxter (2000)GART-NG78GART-78 PI, NFVNAD30N L10V, K14R, E35G, M36I, R41K, L63PB
Masciotra (2000)SM5SM5AF221030PINAI54V, V82A, N88S E35G, L63P, V77I, T96SB
Rousseau (2000)MNR11MNR4555AJ405956IDV, SQV, NFV88L90MG73SK20I, E35G, M36I, I62V, L63P, A71TB
Fitzgibbon (2001)JF-7JF7-M10AF442182NFV D30N I13V, E35G, M36I, R57K, L63PB
 JF-9JF9-M12AF442186NFV D30NK43T, N88DK20T, E35G, M36I, N37S, R57K, L63P, A71V, I85VB
Gonzales (2001)CA1809CA4855AY030724NFV85 L23II13V, K14R, I15V, K20T, E35G, R41K, I64V, V77I, V82I, I93LB
 CA2076CA7686AY030785IDV, NFV52M46L, L90M L10R, E35G, M36I, R57K, Q61E, I62V, L63P, E65D, A71V, I93LB
 CA4766CA11796AY031426IDV, SQV, RTV184M46I, L90MG73S, N83NDL10I, A22V, E35G, M36I, N37D, R41K, I62V, L63P, C67F, H69R, A71V, I72R, V77I, I93LB
 CA4773CA11810AY031433IDV, NFV45L90MG73SL10I, I13V, E35G, M36I, N37D, D60E, Q61E, I62V, L63P, H69Y, A71AV, I72KB
 CA5239CA12913AY031796IDV, NFV186L90MN83DW6WL, L19I, E35G, M36I, N37E, D60E, I62V, L63P, I64V, I93LB
Kempf (2001)DK-2415DK-2415 IDV, RTV134M46I, I54V, V82A I13V, Q18H, K20I, E35G, M36I, N37S, R41K, K43R, L63P, H69K, A71T, P79PA, L89X, Q92QKB
Kantor (2002)CA1113CA3756AY047400SQV, NFV, RTV62I84V, L90M T12M, K20L, E35G, M36I, R57K, L63P, A71VB
Romano (2002)MZ-pt19pt19-t0AF493354SQV, NFV, IDV, RTV M46I, I84V, L90ML10F, L33I, G73S, N83DA22V, E35G, M36I, R41K, I62V, L63P, A71V, I72L, I85VB
Tural (2002)881214881214 SQV, IDV, RTV, NFV183L90MG73TL10V, T12I, I15V, G16A, K20M, E35G, M36I, R41K, I62V, L63P, H69R, K70TB
Gonzales (2003)CA1556CA11045AY305991IDV, NFV, SQV, RTV, APV160V32VI, I54V, I84V, L90ML10FI, V11I, L33LF, G73S, L89VI13IV, I15V, L19P, K20I, A22AV, E35G, M36I, I62V, L63P, A71I, P79A, I85IVB
Saah (2003)AS-33AS-33 NFV34  L10I, L19I, K20T, E35G, I64V, T74S, V77IB
Montes (2004)MB_patFRE00_FRE705AJ577893SQV, NFV162D30NN88DI15V, E35G, M36I, N37D, L63P, V75I, I93LB
 MB_patMOR99_MOR701AJ577954SQV, IDV, NFV, RTV162I84V, L90MG73SK20I, E35G, M36I, I62V, L63P, A71TB
  02_MOR735AJ577955SQV, IDV, NFV, RTV, LPV, Unknown>232I54V, I84V, L90ML10F, G73SK20I, E35G, M36I, I62V, L63P, A71T, I85V, I93NB
Rhee (2005)CA1556CA4445AY796776IDV, NFV, SQV, RTV109I54V, I84V, L90MG73SI15V, L19P, K20I, E35G, M36I, I62V, L63P, A71ITB
  CA20481AY796777IDV, NFV, SQV, RTV, APV, LPV222V32I, I54V, I84V, L90ML33F, G73S, L89VI15V, L19P, K20T, E35G, M36I, K43KQ, I62V, L63P, A71I, P79AB
  CA20616AY796778IDV, NFV, SQV, RTV, APV, LPV228V32VI, I54V, I84V, L90ML10F, V11I, L33LF, G73GS, L89VT12P, I13V, I15V, L19LP, K20T, E35G, M36I, I62V, L63LP, A71X, P79AB
  CA37909AY796779IDV, NFV, SQV, RTV, APV, LPV281V32I, I84V, L90ML10F, V11I, L33F, G73S, L89VT12S, I13V, I15V, L19P, K20T, E35G, M36I, I62V, L63P, K70AE, A71I, P79AB
  CA71564 IDV, NFV, SQV, RTV, APV, LPV, TPV, ATV467V32I, I54IV, I84V, L90ML10F, V11I, L33F, G73S, L89VT12P, I13V, I15V, L19P, K20T, E35G, M36I, I62V, L63P, K70T, A71I, P79AB
 CA2076CA13287AY796861IDV, NFV81M46LV11VIL10CR, K14E, K20T, E35G, M36I, R41RK, R57K, Q61E, I62V, L63P, E65N, A71V, T74TS, Q92QK, I93LB
  CA20318AY796862IDV, NFV, SQV, RTV126M46L, I54IL, I84V, L90M L19LV, K20T, E35G, M36I, R57K, Q61E, I62V, L63P, E65N, A71V, Q92QK, I93LB
  CA23183AY796863IDV, NFV, SQV, RTV172M46L, I54IL, I84V, L90M I13IL, K14E, L19LV, K20MT, E35G, M36I, R57K, Q61E, I62V, L63P, I64IV, E65N, K70KE, A71V, P79PA, Q92K, I93LB
  CA41194AY796864IDV, NFV, SQV, RTV284M46L, I54L, I84V, L90M L10R, I13IV, K14E, L19V, K20T, E35G, M36I, R57K, Q61E, I62V, L63P, I64V, E65N, A71V, P79A, Q92K, I93LB
 CA4439CA10857AY797093IDV, NFV116D30NL10F, N88DK20T, E35G, M36I, I62V, L63P, H69HN, A71VB
 CA4773CA23187AY797147IDV, NFV, RTV, APV157V32I, I54L, I84V, L90ML33F, Q58E, G73SL10I, I13V, E35G, M36I, N37D, D60E, Q61E, I62V, L63P, I66V, H69Y, A71V, I72K, P79SB
  CA41230AY797148IDV, NFV, RTV, APV268V32I, I54L, I84V, L90ML33F, Q58E, G73SL10I, I13V, E35G, M36I, N37D, D60E, Q61E, I62V, L63P, I66V, H69Y, A71V, I72K, P79AB
 CA4791CA24681AY797158NFV, RTV, IDV145L90MG73GCT4TS, I13V, I15V, L19LI, E35G, M36I, I62V, L63P, K70T, A71ATB
  CA37922AY797159NFV, RTV, IDV, LPV225L90MG73CI13V, I15V, E35G, M36I, I62V, L63P, K70TB
 ASRU019ASRU019 RTV, SQV, IDV, NFV118I84V, L90MG73SL10I, V11G, E35G, M36I, Q61E, L63P, A71V, I72V, I93LB
 CA7969CA33510AY797618NFV91L90M K20T, E35G, M36I, R41RK, R57K, I62V, L63P, I64V, T74TS, V82I, I93LB
 CA8454CA21439AY797771NFV172L90M I13V, E35G, M36I, I62V, L63P, I64L, I72V, T74S, I93LB
 CA17673CA41588AY798277NFV277L90M K14R, K20I, E35G, M36I, N37E, K45R, I62V, L63P, I72E, I93LB
 CA18383CA42913AY798295IDV375L90MQ58EL10I, E35G, M36I, I62V, L63A, I93L, C95FB
Baxter (2006)12-12551255-30409DQ876084PINAI54V, I84VV11VIL10I, I13V, K20RT, A22V, E35G, M36I, N37S, R41K, R57K, D60DE, Q61QH, I62IV, L63P, K70R, A71V, I93LB
 12-40484048-30714DQ876154PINAM46L, L90MG73CL10R, I15V, L19P, K20I, E35G, M36L, N37T, P39S, K55R, Q61D, I62V, L63P, C67L, A71T, I72T, T74S, Q92KB
 12-16471647-30421DQ876200PINAV32I, M46I, I47V, I54M, I84V, L90MV11I, L33I, L89VL10I, I13V, G16A, L19P, K20V, A22V, E35G, N37D, D60E, L63P, K70T, A71I, G73E, V77I, I93LB
 12-22712271-30822DQ876323Unknown, PINAG48V, I50IV, I54T, V82A, I84IVK43T, G73GA, L89VL10I, I13V, L19P, K20IM, E35G, M36I, I62V, L63P, C67CY, A71VB
 12-22672267-30820DQ876363PINAV32I, M46I, I47V, I54M, L90MF53L, G73A, L89VL10I, I13V, L19P, K20V, A22AV, E35G, M36I, D60E, I62V, L63P, I64V, A71I, I72T, V77I, V82I, I85VB
 12-23422342-30730DQ876709PINAM46I, I54V, V82A, L90LML10F, L33F, T74PI13V, I15V, G16E, L19I, K20T, E35G, M36I, P39T, R41RK, R57K, I62V, L63C, A71V, I72T, I93LB
 12-31193119-40623DQ879132PI, RTV, TPV>62M46L, I54V, V82T, L90MV11I, L33I, N88DI15V, K20V, E35G, M36I, R41K, I62V, L63P, I66L, A71T, I72M, I85V, F99YB
 12-16881688-30417DQ876973PINAM46MI, I54V, V82VA, L90MG73SL10V, I15V, K20M, E35G, M36I, N37ND, I62V, L63P, C67F, I72LB
 48-10421042-30617DQ877366PINAM46I, I54V, I84V, L90ML10F, K43KT, Q58QE, G73SK14R, K20I, E35G, M36I, N37D, R57K, D60E, Q61E, I62V, L63P, I66F, H69Y, A71T, I72T, I93LB
 48-10541054-30701DQ877420PINAM46MI, I54V, L76V, L90ML89VL10I, I15V, K20T, E35G, M36I, N37D, I62V, L63P, H69K, A71AV, V77I, V82I, I85VB
 48-42134213-30429DQ878446PINAI54L, V82A, L90ML10F, L33F, Q58E, L89VI13V, K20V, E35G, M36I, N37D, R57K, D60E, I62V, L63P, A71T, Q92KB
 48-42674267-40518DQ878500PI, RTV, TPV>47M46I, I54T, V82VL, I84V, L90ML33IL10I, I13V, K20I, E34Q, E35G, M36I, L63P, I64V, T74SB
 48-50765076-30807DQ878586PINAM46I, I54V, V82F, L90MG73CL10I, I13M, K20I, E35G, M36I, D60E, I62V, L63P, I64V, I72L, V77VI, I93LB
 48-91829182-30901DQ877535PINAM46I, I54A, I84V, L90ML10F, L33F, Q58E, T74PT12K, I13V, I15V, K20T, E35G, M36L, R41K, I62V, L63Q, I64V, A71V, L89M, I93LB
 48-93039303-30922DQ877588PINAD30N, M46I, I50VL10F, N88DK20I, E35G, M36I, Q61E, L63PB
Mitsuya (2006)CA3979CA11780DQ780904IDV, SQV, NFV, RTV149I54IV, I84IV, L90MN88NDK20I, E35G, M36I, I62V, L63P, H69NT, A71X, I72V, T74TSB
De Meyer (2009)LPV07LPV07BL PINAM46I, I84VL89VL10I, K20I, E35G, M36I, H69K, A71TB
  LPV07-48w PI, LPV>48M46I, L76V, I84VL89VL10I, K20I, E35G, M36I, H69K, A71TB
Dau (2010)05122A05122AGU581657PINAI84IVL10FG17E, K20T, E35G, M36I, Q61N, L63AB
 06857A06857AGU581789PINAI54A, L90ML10F, G73S, L89VI13V, I15V, K20T, E35G, M36I, N37S, R57K, I62V, L63Q, A71V, T74S, V77I, I93LB
 08882A08882AGU581953PINAG48V, I50IV, I54T, V82AK43T, G73A, L89VP9PR, L10I, I13V, L19P, K20M, E35G, M36I, I62V, L63P, C67CY, A71VB
Rhee (2010)CA1257CA123363GQ213726SQV, IDV, LPV, Unknown>543M46I, I54V, I84V, L90ML10F, V11I, G73ST12P, I13V, I15V, L19P, K20I, E35G, M36I, L63P, A71V, I72L, I93LB
 CA38129CA84909GQ213273PI, Unknown, DRV, RTV>23V32I, M46I, I47V, I54M, I84IV, L90MV11I, L33LF, Q58E, G73S, L89VL10I, T12K, I13V, K20V, E35G, M36I, N37ND, R57K, L63P, I64V, A71IVB
Jones (2012)140306140306JN669588PINAM46I, I54L, L76V, I84V, L90LM L10I, I15V, K20T, E35G, M36I, N37ND, D60E, I62V, L63P, A71V, I85V, L89I, I93LB
 158406158406JN669917PINAI84V, L90ML10F, T74PI13V, I15V, K20I, E35G, M36I, I62V, L63P, A71V, I72T, I93MB
 159242159242JN669945PINAM46L, L90ML10FI, L33F, G73S, L89VI13V, K20V, E35G, M36I, N37D, R41K, I62V, L63P, I93LB
 199497199497JN671171PINAD30NN88DG16E, K20M, E35G, M36I, N37NH, P39S, I62V, L63P, A71V, T74TS, I93LB
 201412201412JN671222PINAL90ML23LIT4S, L19I, K20KM, E35G, M36I, I62V, L63P, H69Q, K70E, A71AT, Q92QKB