Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	E35G
Rx	>= 1 PI
IncludeMixtures	No

References	21
Patients	54
Isolates	68

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Winters (1997)	KA0011625	1162528862		NFV	138	D30N	N88D	I3V, L10I, E35G, M36I, R41K, L63P, I93L	B
Winters (1998)	MW-ins14	jci-14	AF096894	PI	NA	I54V, I84V, L90M	G73S	I15V, L19P, K20I, E35G, M36I, I62V, L63P, A71X	B
Baxter (2000)	GART-NG78	GART-78		PI, NFV	NA	D30N		L10V, K14R, E35G, M36I, R41K, L63P	B
Masciotra (2000)	SM5	SM5	AF221030	PI	NA	I54V, V82A, N88S		E35G, L63P, V77I, T96S	B
Rousseau (2000)	MNR11	MNR4555	AJ405956	IDV, SQV, NFV	88	L90M	G73S	K20I, E35G, M36I, I62V, L63P, A71T	B
Fitzgibbon (2001)	JF-7	JF7-M10	AF442182	NFV		D30N		I13V, E35G, M36I, R57K, L63P	B
	JF-9	JF9-M12	AF442186	NFV		D30N	K43T, N88D	K20T, E35G, M36I, N37S, R57K, L63P, A71V, I85V	B
Gonzales (2001)	CA1809	CA4855	AY030724	NFV	85		L23I	I13V, K14R, I15V, K20T, E35G, R41K, I64V, V77I, V82I, I93L	B
	CA2076	CA7686	AY030785	IDV, NFV	52	M46L, L90M		L10R, E35G, M36I, R57K, Q61E, I62V, L63P, E65D, A71V, I93L	B
	CA4766	CA11796	AY031426	IDV, SQV, RTV	184	M46I, L90M	G73S, N83ND	L10I, A22V, E35G, M36I, N37D, R41K, I62V, L63P, C67F, H69R, A71V, I72R, V77I, I93L	B
	CA4773	CA11810	AY031433	IDV, NFV	45	L90M	G73S	L10I, I13V, E35G, M36I, N37D, D60E, Q61E, I62V, L63P, H69Y, A71AV, I72K	B
	CA5239	CA12913	AY031796	IDV, NFV	186	L90M	N83D	W6WL, L19I, E35G, M36I, N37E, D60E, I62V, L63P, I64V, I93L	B
Kempf (2001)	DK-2415	DK-2415		IDV, RTV	134	M46I, I54V, V82A		I13V, Q18H, K20I, E35G, M36I, N37S, R41K, K43R, L63P, H69K, A71T, P79PA, L89X, Q92QK	B
Kantor (2002)	CA1113	CA3756	AY047400	SQV, NFV, RTV	62	I84V, L90M		T12M, K20L, E35G, M36I, R57K, L63P, A71V	B
Romano (2002)	MZ-pt19	pt19-t0	AF493354	SQV, NFV, IDV, RTV		M46I, I84V, L90M	L10F, L33I, G73S, N83D	A22V, E35G, M36I, R41K, I62V, L63P, A71V, I72L, I85V	B
Tural (2002)	881214	881214		SQV, IDV, RTV, NFV	183	L90M	G73T	L10V, T12I, I15V, G16A, K20M, E35G, M36I, R41K, I62V, L63P, H69R, K70T	B
Gonzales (2003)	CA1556	CA11045	AY305991	IDV, NFV, SQV, RTV, APV	160	V32VI, I54V, I84V, L90M	L10FI, V11I, L33LF, G73S, L89V	I13IV, I15V, L19P, K20I, A22AV, E35G, M36I, I62V, L63P, A71I, P79A, I85IV	B
Saah (2003)	AS-33	AS-33		NFV	34			L10I, L19I, K20T, E35G, I64V, T74S, V77I	B
Montes (2004)	MB_patFRE	00_FRE705	AJ577893	SQV, NFV	162	D30N	N88D	I15V, E35G, M36I, N37D, L63P, V75I, I93L	B
	MB_patMOR	99_MOR701	AJ577954	SQV, IDV, NFV, RTV	162	I84V, L90M	G73S	K20I, E35G, M36I, I62V, L63P, A71T	B
		02_MOR735	AJ577955	SQV, IDV, NFV, RTV, LPV, Unknown	>232	I54V, I84V, L90M	L10F, G73S	K20I, E35G, M36I, I62V, L63P, A71T, I85V, I93N	B
Rhee (2005)	CA1556	CA4445	AY796776	IDV, NFV, SQV, RTV	109	I54V, I84V, L90M	G73S	I15V, L19P, K20I, E35G, M36I, I62V, L63P, A71IT	B
		CA20481	AY796777	IDV, NFV, SQV, RTV, APV, LPV	222	V32I, I54V, I84V, L90M	L33F, G73S, L89V	I15V, L19P, K20T, E35G, M36I, K43KQ, I62V, L63P, A71I, P79A	B
		CA20616	AY796778	IDV, NFV, SQV, RTV, APV, LPV	228	V32VI, I54V, I84V, L90M	L10F, V11I, L33LF, G73GS, L89V	T12P, I13V, I15V, L19LP, K20T, E35G, M36I, I62V, L63LP, A71X, P79A	B
		CA37909	AY796779	IDV, NFV, SQV, RTV, APV, LPV	281	V32I, I84V, L90M	L10F, V11I, L33F, G73S, L89V	T12S, I13V, I15V, L19P, K20T, E35G, M36I, I62V, L63P, K70AE, A71I, P79A	B
		CA71564		IDV, NFV, SQV, RTV, APV, LPV, TPV, ATV	467	V32I, I54IV, I84V, L90M	L10F, V11I, L33F, G73S, L89V	T12P, I13V, I15V, L19P, K20T, E35G, M36I, I62V, L63P, K70T, A71I, P79A	B
	CA2076	CA13287	AY796861	IDV, NFV	81	M46L	V11VI	L10CR, K14E, K20T, E35G, M36I, R41RK, R57K, Q61E, I62V, L63P, E65N, A71V, T74TS, Q92QK, I93L	B
		CA20318	AY796862	IDV, NFV, SQV, RTV	126	M46L, I54IL, I84V, L90M		L19LV, K20T, E35G, M36I, R57K, Q61E, I62V, L63P, E65N, A71V, Q92QK, I93L	B
		CA23183	AY796863	IDV, NFV, SQV, RTV	172	M46L, I54IL, I84V, L90M		I13IL, K14E, L19LV, K20MT, E35G, M36I, R57K, Q61E, I62V, L63P, I64IV, E65N, K70KE, A71V, P79PA, Q92K, I93L	B
		CA41194	AY796864	IDV, NFV, SQV, RTV	284	M46L, I54L, I84V, L90M		L10R, I13IV, K14E, L19V, K20T, E35G, M36I, R57K, Q61E, I62V, L63P, I64V, E65N, A71V, P79A, Q92K, I93L	B
	CA4439	CA10857	AY797093	IDV, NFV	116	D30N	L10F, N88D	K20T, E35G, M36I, I62V, L63P, H69HN, A71V	B
	CA4773	CA23187	AY797147	IDV, NFV, RTV, APV	157	V32I, I54L, I84V, L90M	L33F, Q58E, G73S	L10I, I13V, E35G, M36I, N37D, D60E, Q61E, I62V, L63P, I66V, H69Y, A71V, I72K, P79S	B
		CA41230	AY797148	IDV, NFV, RTV, APV	268	V32I, I54L, I84V, L90M	L33F, Q58E, G73S	L10I, I13V, E35G, M36I, N37D, D60E, Q61E, I62V, L63P, I66V, H69Y, A71V, I72K, P79A	B
	CA4791	CA24681	AY797158	NFV, RTV, IDV	145	L90M	G73GC	T4TS, I13V, I15V, L19LI, E35G, M36I, I62V, L63P, K70T, A71AT	B
		CA37922	AY797159	NFV, RTV, IDV, LPV	225	L90M	G73C	I13V, I15V, E35G, M36I, I62V, L63P, K70T	B
	ASRU019	ASRU019		RTV, SQV, IDV, NFV	118	I84V, L90M	G73S	L10I, V11G, E35G, M36I, Q61E, L63P, A71V, I72V, I93L	B
	CA7969	CA33510	AY797618	NFV	91	L90M		K20T, E35G, M36I, R41RK, R57K, I62V, L63P, I64V, T74TS, V82I, I93L	B
	CA8454	CA21439	AY797771	NFV	172	L90M		I13V, E35G, M36I, I62V, L63P, I64L, I72V, T74S, I93L	B
	CA17673	CA41588	AY798277	NFV	277	L90M		K14R, K20I, E35G, M36I, N37E, K45R, I62V, L63P, I72E, I93L	B
	CA18383	CA42913	AY798295	IDV	375	L90M	Q58E	L10I, E35G, M36I, I62V, L63A, I93L, C95F	B
Baxter (2006)	12-1255	1255-30409	DQ876084	PI	NA	I54V, I84V	V11VI	L10I, I13V, K20RT, A22V, E35G, M36I, N37S, R41K, R57K, D60DE, Q61QH, I62IV, L63P, K70R, A71V, I93L	B
	12-4048	4048-30714	DQ876154	PI	NA	M46L, L90M	G73C	L10R, I15V, L19P, K20I, E35G, M36L, N37T, P39S, K55R, Q61D, I62V, L63P, C67L, A71T, I72T, T74S, Q92K	B
	12-1647	1647-30421	DQ876200	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	V11I, L33I, L89V	L10I, I13V, G16A, L19P, K20V, A22V, E35G, N37D, D60E, L63P, K70T, A71I, G73E, V77I, I93L	B
	12-2271	2271-30822	DQ876323	Unknown, PI	NA	G48V, I50IV, I54T, V82A, I84IV	K43T, G73GA, L89V	L10I, I13V, L19P, K20IM, E35G, M36I, I62V, L63P, C67CY, A71V	B
	12-2267	2267-30820	DQ876363	PI	NA	V32I, M46I, I47V, I54M, L90M	F53L, G73A, L89V	L10I, I13V, L19P, K20V, A22AV, E35G, M36I, D60E, I62V, L63P, I64V, A71I, I72T, V77I, V82I, I85V	B
	12-2342	2342-30730	DQ876709	PI	NA	M46I, I54V, V82A, L90LM	L10F, L33F, T74P	I13V, I15V, G16E, L19I, K20T, E35G, M36I, P39T, R41RK, R57K, I62V, L63C, A71V, I72T, I93L	B
	12-3119	3119-40623	DQ879132	PI, RTV, TPV	>62	M46L, I54V, V82T, L90M	V11I, L33I, N88D	I15V, K20V, E35G, M36I, R41K, I62V, L63P, I66L, A71T, I72M, I85V, F99Y	B
	12-1688	1688-30417	DQ876973	PI	NA	M46MI, I54V, V82VA, L90M	G73S	L10V, I15V, K20M, E35G, M36I, N37ND, I62V, L63P, C67F, I72L	B
	48-1042	1042-30617	DQ877366	PI	NA	M46I, I54V, I84V, L90M	L10F, K43KT, Q58QE, G73S	K14R, K20I, E35G, M36I, N37D, R57K, D60E, Q61E, I62V, L63P, I66F, H69Y, A71T, I72T, I93L	B
	48-1054	1054-30701	DQ877420	PI	NA	M46MI, I54V, L76V, L90M	L89V	L10I, I15V, K20T, E35G, M36I, N37D, I62V, L63P, H69K, A71AV, V77I, V82I, I85V	B
	48-4213	4213-30429	DQ878446	PI	NA	I54L, V82A, L90M	L10F, L33F, Q58E, L89V	I13V, K20V, E35G, M36I, N37D, R57K, D60E, I62V, L63P, A71T, Q92K	B
	48-4267	4267-40518	DQ878500	PI, RTV, TPV	>47	M46I, I54T, V82VL, I84V, L90M	L33I	L10I, I13V, K20I, E34Q, E35G, M36I, L63P, I64V, T74S	B
	48-5076	5076-30807	DQ878586	PI	NA	M46I, I54V, V82F, L90M	G73C	L10I, I13M, K20I, E35G, M36I, D60E, I62V, L63P, I64V, I72L, V77VI, I93L	B
	48-9182	9182-30901	DQ877535	PI	NA	M46I, I54A, I84V, L90M	L10F, L33F, Q58E, T74P	T12K, I13V, I15V, K20T, E35G, M36L, R41K, I62V, L63Q, I64V, A71V, L89M, I93L	B
	48-9303	9303-30922	DQ877588	PI	NA	D30N, M46I, I50V	L10F, N88D	K20I, E35G, M36I, Q61E, L63P	B
Mitsuya (2006)	CA3979	CA11780	DQ780904	IDV, SQV, NFV, RTV	149	I54IV, I84IV, L90M	N88ND	K20I, E35G, M36I, I62V, L63P, H69NT, A71X, I72V, T74TS	B
De Meyer (2009)	LPV07	LPV07BL		PI	NA	M46I, I84V	L89V	L10I, K20I, E35G, M36I, H69K, A71T	B
		LPV07-48w		PI, LPV	>48	M46I, L76V, I84V	L89V	L10I, K20I, E35G, M36I, H69K, A71T	B
Dau (2010)	05122A	05122A	GU581657	PI	NA	I84IV	L10F	G17E, K20T, E35G, M36I, Q61N, L63A	B
	06857A	06857A	GU581789	PI	NA	I54A, L90M	L10F, G73S, L89V	I13V, I15V, K20T, E35G, M36I, N37S, R57K, I62V, L63Q, A71V, T74S, V77I, I93L	B
	08882A	08882A	GU581953	PI	NA	G48V, I50IV, I54T, V82A	K43T, G73A, L89V	P9PR, L10I, I13V, L19P, K20M, E35G, M36I, I62V, L63P, C67CY, A71V	B
Rhee (2010)	CA1257	CA123363	GQ213726	SQV, IDV, LPV, Unknown	>543	M46I, I54V, I84V, L90M	L10F, V11I, G73S	T12P, I13V, I15V, L19P, K20I, E35G, M36I, L63P, A71V, I72L, I93L	B
	CA38129	CA84909	GQ213273	PI, Unknown, DRV, RTV	>23	V32I, M46I, I47V, I54M, I84IV, L90M	V11I, L33LF, Q58E, G73S, L89V	L10I, T12K, I13V, K20V, E35G, M36I, N37ND, R57K, L63P, I64V, A71IV	B
Jones (2012)	140306	140306	JN669588	PI	NA	M46I, I54L, L76V, I84V, L90LM		L10I, I15V, K20T, E35G, M36I, N37ND, D60E, I62V, L63P, A71V, I85V, L89I, I93L	B
	158406	158406	JN669917	PI	NA	I84V, L90M	L10F, T74P	I13V, I15V, K20I, E35G, M36I, I62V, L63P, A71V, I72T, I93M	B
	159242	159242	JN669945	PI	NA	M46L, L90M	L10FI, L33F, G73S, L89V	I13V, K20V, E35G, M36I, N37D, R41K, I62V, L63P, I93L	B
	199497	199497	JN671171	PI	NA	D30N	N88D	G16E, K20M, E35G, M36I, N37NH, P39S, I62V, L63P, A71V, T74TS, I93L	B
	201412	201412	JN671222	PI	NA	L90M	L23LI	T4S, L19I, K20KM, E35G, M36I, I62V, L63P, H69Q, K70E, A71AT, Q92QK	B

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