Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	L33V
Rx	>= 1 PI
IncludeMixtures	No

References	48
Patients	113
Isolates	126

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Condra (1996)	pt-H	ptHW12		IDV	12	V82T, L90M	G73S	I13V, L33V, N37C, I62V, L63P, A71V, I72M	B
Molla (1996)	RTV-203	RTV203W32		RTV	32			L33V, E35D, N37A, L63P, I64V, I93L	B
Schmit (1996)	JCSB7	B7W78		RTV	78	I84V		R8Q, L33V, E34K, E35D, N37T, R57K, L63P, I64V	B
Patick (1998)	503-213	503-213W35		NFV	35	L90M	G73S	K20I, L33V, I62V, L63P, A71V, V77I	B
Zolopa (1999)	CA630	CA3150	AF085115	SQV, IDV	44			L33V, L63P, K70T	B
Bacheler (2000)	LB3-P25	P25-0		IDV	2			L33V, R41K, L63Q, I64V, E65D	B
		P25-18		IDV	20			L33V, R41K, L63Q, I64V	B
Balotta (2000)	CB-219	CB-219	AF252073	SQV				L33V, L63P, H69Y, T74S	B
Baxter (2000)	GART-NG4	GART-4		PI, NFV	NA	D30N	L10LF, N88D	I13V, L33V, E35D, M36I, I62IV, L63P	B
	GART-NG70	GART-70		PI, IDV	NA			L33V, L63S, I64V	B
Caride (2001)	ERRJ01	PROERRJ01	AF165567	SQV				L33V, N37C, I64V, G78R	B
Cinque (2001)	Pat14	14csf_Post	AF266539	SQV, RTV	8		I47IL	L10I, I13V, G16E, L33V, E35D, N37T, R57K, I62V, L63T, I64V, C67Q	B
Eshleman (2001)	A033	AF357805	AF357805	NFV	49			R8RP, T12S, I13V, L19I, K20R, L33V, R41I, R57K, D60E, L63P, I64V, V75VL	B
	A096	AF357778	AF357778	NFV	10			L10V, I13V, K14KM, L19LI, L33V, R41RK, R57K, L63H, I64V, E65D	B
		AF357825	AF357825	NFV	50	N88NS		L10V, I13V, K14R, L19I, K20I, L33V, R57K, I62V, L63Q, I64V, E65D, T74S, I85IL	B
Gonzales (2001)	CA1457	CA3891	AY030593	IDV, NFV	47			L33V, N37S, R41K, I64V, I93L	B
	CA3893	CA9650	AY030898	IDV	127			L10V, I13V, L33V, N37A, P39S, I64V, K70R	B
	CA4097	CA9767	AY031089	NFV	85	D30N		L33V, E34D, M36V, K45Q, I64V, I72IM	B
	CA4128	CA9834	AY031117	IDV, NFV	114	D30N	N88D	I13V, K20T, L33V, I64V, A71V	B
	CA4851	CA12031	AY031491	Unknown, IDV	>70			L10I, K14R, L33V, N37S, P39S, I62V, L63P, I64V, I93L	B
	CA4900	CA12098	AY031540	IDV	56	I54V, V82A	L10F	L33V, L63P, A71V	B
Gibb (2002)	DMG22	22_w32		NFV	32			T12N, L33V, N37C, I62V, L63P, I64L, H69Q	B
	DMG56	56_w18		NFV	19			L33V, N37C, L63Q, I64V	B
	DMG59	59_w52		NFV	53			L33V, N37C, L63Q, I64V	B
	DMG71	71_w83		NFV	83			L33V, N37C, L63Q, I64V	B
Maguire (2002)	SW32493	SW32493		APV	48	M46I, I50V		L10I, I13V, K14KR, L33V, E35ED, N37X, R41K, L63V, I64V, A71AV, I93L	B
Margot (2002)	MM-553936658	5539366581		PI	NA			L10V, T12S, I13V, L33V, I64V	B
	MM-433736803	4337368031		PI	NA			K14R, L33V, N37T, P39S, R41K, D60E, I62IV, I64V	B
	MM-262036623	2620366231		PI	NA			I13V, L33V, I64V	B
	MM-352136759	3521367591		PI	NA	D30N	N88D	L33V, E35D, M36I, R41K, L63P, I64V, V75I	B
Masquelier (2002)	apv4	apv4M6	AY133496	NFV	24	D30N	N88D	T12V, L33V, N37A, R41K, R57K, D60E, L63P	B
Tural (2002)	368685	368685		SQV, NFV	126	D30N	N88D	I13V, L33V, P39S, L63P, H69Q, A71I, I85V	B
	881218	881218		NFV	102	L90M	G73S	L10I, L33V, R41K, L63P, I93L	B
Venturi (2002)	GV-45	GV-45.1	AF517297	IDV				L33V, N37C, R57K, I64V	B
de Sa Filho (2003)	BREPM029	BREPM029	AY182792	IDV				L33V, R57K, L63P	B
Monno (2003)	ML_Pat27	ML_Pat27		PI	NA			L10V, I13V, L33V, N37T, R41KL, L63Q, I64V	B
Saah (2003)	AS-43	AS-43		NFV	75			L33V, R41K, L63Q, I64V	B
Shafer (2003)	A384_3111	3111b	EF548286	NFV	26	D30N		I13V, G17GW, K20T, L33V, L63P, H69K	B
	A384_1092	1092b	EF548445	NFV, Unknown	>31			I15V, G16GE, L19LI, L33V, N37A, R57K, I64V	B
		1092c		NFV, Unknown	>31			I15V, G16E, L33V, N37A, R57K, I64V	B
	A384_0842	0842b	EF548466	NFV	34	D30N	N88ND	L10V, T12I, I13V, L33V, N37S, R57K, L63P	B
	A384_1478	1478b	EF548892	NFV	23			L33V, E35D, N37S, L63P, I64V, V82VI, I93L	B
	A384_4583	4583b	EF549337	NFV, Unknown	>51			L33V, R41K, D60E, L63P, L89LM	B
Wu (2003)	CA630	CA1200	AF544412	SQV, IDV, RTV	84	I84V, L90M	G73GS	L10I, K20KM, L33V, L63P, K70T	B
Colonno (2004)	RC-008-003-306	003-30621		NFV	56	D30N		T12S, I13V, K14T, L19V, L33V, M36I, N37S, K45Q, I64V	B
Gomez-Carrillo (2004)	99055	99055	AY365594	PI	NA			L33V, N37S, L63C, I72V, L89M	B
	119801	119801	AY365972	PI	NA			T12K, I13V, G16E, L19I, L33V, N37S, P39S, I62V, L63H, I64V, I72IV	B
	125287	125287	AY366044	PI	NA			L10V, I13V, L33V, K45R, L63T, I64V	B
Gulick (2004)	RG369	RG369w22		NFV	3			L19I, L33V, N37T, Y59H, I64V	B
	RG65	RG65w47		ATV	18			L33V, N37S, R41K, I64V, I93L	B
Montes (2004)	MB_patDAV	00_DAVC705	AJ577874	IDV	82			T12S, L33V, N37C, I64V	B
	MB_patDAV C	01_DAVC719	AJ577875	IDV, NFV	115			T12S, L33V, M36V, N37C, Q61H, I64V	B
Garcia-Bujalance (2005)	GBS_02	GBS_02	AY872283	RTV		D30N	N88D	I13V, L33V, L63P	B
	GBS_34	GBS_34	AY872315	SQV, RTV, LPV		I54V, V82CFIS, L90M	Q58QE, G73GS, N88ND	L10I, I13V, Q18H, K20M, L33V, N37T, I62V, L63P, A71V, C95L	B
Kagan (2005)	175848	175848		PI	NA	V32I, M46I, I47A, L90M	L10F, L89V	T4A, I13V, K20T, L33V, I62V, L63P, H69Y, A71V, I93L	B
Ochoa de Echaguen (2005)	B-0325	B-0325	AY833581	IDV				T12S, L33V, L63P, I64V, H69K, I93L	B
Rhee (2005)	CA630	CA3152	AY796446	SQV, IDV, RTV	79	I84V, L90M	F53FL, G73GS	L10I, K20KM, L33V, L63P, K70T	B
	CA4097	CA33349	AY797016	NFV	233	D30N		I13V, L33V, E35D, M36V, K45Q, I64V	B
	CA9649	CA23560	AY797782	IDV, LPV	134			I13V, L33V, N37S, P39S, I64V	B
	CA9668	CA33507	AY797792	NFV, Unknown	>4			L33V, N37C, R41K, L63P, I93L	B
	CA9725	CA23833	AY797826	NFV	27			K20KE, L33V, N37T, L63P, I93L	B
	SWC-4670	4670-2338		SQV	13			T12S, L33V, N37C, I64V, I93L	B
		4670-2557		SQV, Unknown	>23			T12S, L33V, N37C, I64V, I93L, C95X	B
	CA14156	CA33253	AY797983	NFV	92	M46MI		G16E, L33V, M36I, P39S, I64V, I72V	B
	CA14379	CA34069	AY798063	LPV	8			L33V, N37A, R57K, L63P, I64V	B
		CA41378	AY798064	LPV	43			L33V, N37A, R57K, L63P, I64V	B
Baxter (2006)	12-2077	2077-30609	DQ876018	PI	NA	V32I, M46I, I47V, I54M, V82T, L90M	V11I	L10R, I13V, K20I, L33V, K55R, I62V, L63P, A71L, I72L, Q92R	B
	12-1785	1785-30502	DQ876077	PI	NA	M46I, I54M, L76V, I84V, L90M	L10F, G73S, L89V	I13V, Q18H, K20T, L33V, E35EDG, M36MI, N37NK, R57K, I62V, L63PS, A71V, I72L	B
	12-1302	1302-30711	DQ876209	PI	NA	M46I, I54V, I84V, L90M	L10F, Q58E, G73S, L89V	I13V, K20T, L33V, K55R, D60E, Q61DE, I64V, T91TS	B
	12-2016	2016-30701	DQ876694	PI	NA	D30N		T12A, I13V, G16E, K20KT, L33V, E35D, N37Q, I62V, L63H, I64V	B
	12-1196	1196-30912	DQ879103	PI, RTV, TPV	>27	M46I, I54A, I84V, L90M	V11I, G73T	L10I, I13V, Q18H, K20I, L33V, M36I, F53W, K55KR, L63P, I64V, A71V, I72IT	B
	12-1245	1245-30318	DQ877085	PI	NA	M46I, I47V, I54M, L76V, I84V, L90M	L10F, V11VI, L89V	I13V, G16A, K20M, L33V, K55R, I62V, L63P, A71V	B
	12-1269	1269-30318	DQ877136	PI	NA	M46I, I47V, I54M, L76V, I84V, L90M	L10F, L89V	I13V, G16A, K20M, L33V, K55R, I62V, L63P, A71V	B
	48-1807	1807-30923	DQ877437	PI	NA	I54M, I84V, L90M	V11I, F53L, Q58QE	T12S, L19I, K20I, L33V, L63P, A71I	B
	48-3048	3048-30319	DQ877959	PI	NA	L90LIM		T12TPS, I13IV, K14KR, L19LI, L33V, M36MI, N37ND, I62IV, L63P, A71AT, I72V	B
	48-3055	3055-40212	DQ877967	PI, RTV, TPV	>43	V32I, M46I, I47V, L90M	L89V	R8Q, L10I, T12A, I13V, K20T, L33V, M36I, R41K, L63P, A71T	B
	48-4170	4170-30407	DQ878404	PI	NA			L33V, N37S, R41K, I64V, I93L	B
	48-4235	4235-30819	DQ878467	PI	NA	L90LM		L33V, N37C, Q61E, L63P	B
	48-4241	4241-40707	DQ878473	PI, RTV, TPV	>59	M46I, I47V, I54A	N88D, L89V	L10I, I13V, Q18H, K20M, L33V, N37D, K55R, L63P, I66V, A71I, I72V, V77VI, Q92K	B
	48-5022	5022-30606	DQ878556	PI	NA	M46I, I54V, L76V, I84V, L90M	L10F, V11I, Q58E, G73A, L89V	I13V, K20I, L33V, E35K, M36I, K55R, D60E, I62V, L63P, I64V, A71V, T91S, I93L	B
	48-6015	6015-30904	DQ878614	PI, RTV, TPV	>24	M46I, I54A, I84V, L90M	L10FI, G73S, L89V	V11L, I13V, K14KR, I15V, K20I, L33V, I62V, L63P, A71V, I72L	B
		6015-40805	DQ878613	PI, RTV, TPV	>72	M46I, I54A, I84V, L90M	K43KT, G73S, L89V	L10IV, V11L, I13V, K14R, I15V, K20I, L33V, D60DE, I62V, L63P, A71V, I72L	B
	48-6106	6106-30618	DQ878698	PI	NA	V32I, M46I, I47V, I84V, L90M	G73GA, T74TP	L10V, I13V, K20M, L33V, N37D, L63P, H69K	B
	48-7050	7050-30429	DQ878921	PI	NA			I13IV, L33V, P39S, L63P	B
	48-7102	7102-30728	DQ878955	PI	NA	M46MI, I47A, I84V		I13V, K20KT, L33V, N37C, R57K, L63P, I64V	B
		7102-40225	DQ878956	PI, RTV, TPV	>30	M46I, I47A, I84V		L10V, I13V, K20T, L33V, M36I, N37C, R57K, L63P, I64V	B
	48-7161	7161-30609	DQ878999	PI	NA			L10V, T12V, K14R, L33V, N37D, L63P, Q92QK	B
	48-9204	9204-30916	DQ877581	PI	NA			L33V, L63P, I64V, V77I	B
	48-9102	9102-30908	DQ877691	PI	NA	M46I, I54V, I84V, L90M	G73S	L10I, Q18H, L19P, K20I, L24F, L33V, M36I, N37S, I62V, L63P, H69L, A71T, I72R, I93M	B
	48-8018	8018-30729	DQ879063	PI	NA	M46L, I54V, V82A	L24I, F53L	L10I, I13V, K20T, L33V, L63P, I64V	B
Mitsuya (2006)	CA4128	CA33490	DQ780906	IDV, NFV, SQV, RTV	266	D30N, I54IL, I84V, L90LM	L10F, N88D	I13V, K20T, L33V, I64V, A71V	B
Rhee (2006)	CA4900	CA37763		IDV, APV	229	I54M, V82A	L10F	L33V, R41RK, L63P	B
Santos (2006)	PA342	PA342	DQ344012	IDV, RTV, LPV	156			L33V, N37S, R41K, I64V, I93L	B
McGrath (2007)	10	DMG_10a		ATV	48			L10LI, I13IV, L33V, N37X, R41RK, I62V, L63APS, I64V, C67CY, H69HQ	B
von Wyl (2007)	2	697745	EF449969	PI	NA	D30N		T12S, I13V, K14T, L19V, L33V, M36I, N37S, K45Q, I64V	B
Riddler (2008)	RG11340	RG11340w131		LPV	131			T12P, I13V, L33V, I62V, L63S, I64V, Q92E	B
	RG13005	RG13005w118		LPV	118			L33V, W42Y, L63P, I64V, H69Y, I72V	B
	RG31923	RG31923w67		LPV	67		K43T	T12P, I13V, L33V, L63S, I64V, C67Y	B
	RG83358	RG83358w32		LPV	26			L33V, L63P, A71T, I72E	B
	RG86088	RG86088w73		LPV	48			L33V, N37C, R41K, L63Q, I64V, E65ED	B
	RG90663	RG90663w99		LPV	94			L10I, T12S, I13V, L19I, L33V, I62V, L63LS, I64V, C67Y	B
Cardoso (2009)	3145	BRGO3145	FJ638465	PI	NA			L33V, N37S, R41K, L63P, I64V, H69K, I93L	B
Dumans (2009)	RENA573	RENA573	FJ405090	IDV	66			I13V, K14R, L33V, N37E, R57K, L63LP, I64V, K70R, I72T, I93IL	B
Rhee (2009)	CA14311	CA64023	FJ983359	APV, RTV, ATV, LPV, FPV	369	V32I, M46IV, I47V, I54M, I84V, L90M	L10F, V11I, G73T, L89V	I13V, L19Q, K20M, L33V, E35A, M36I, R57K, I62V, L63P, I64V, T74A	B
	CA21076	CA48465	FJ983484	NFV	338	D30N		L33V, K45I, A71V	B
Thomson (2009)	SP_B_053	RU_SP_B_053	FJ009810	LPV	24			L33V, N37Y, I62V, L63P, I64L, H69Q	B
Dau (2010)	06164A	06164A	GU581711	PI	NA			I13V, L33V, N37D, R41K, L63P, I66V, A71T, I93L	B
	08059A	08059A	GU581891	PI	NA	L90LM		L10V, I13V, K20KT, L33V, K43KR, I62IV, I64V, T74TS	B
	08588A	08588A	GU581927	PI	NA	V32I, I47V, I54L	L10F	I13V, K20T, L33V, L63P, I64V	B
	09540A	09540A	GU581974	PI	NA			L33V, L63S, I64V	B
	10775A	10775A	GU582018	PI	NA	M46I	N88T	L10I, I13V, L33V, N37D, I62V	B
Rangel (2010)	HIV270b	HIV270b	GU807524	PI	NA	I84IV, L90M	L10LF, V32VL, L89V	I13V, K20KT, L33V, E34EQ, N37C, R41RK, Q61QH, I62IV, L63P, I66IV, A71AT, I93IL, C95CF, F99FC	B
Rhee (2010)	CA3972	CA68568	GQ212298	IDV, SQV, NFV, RTV, APV, ATV, TPV	599	M46I, I54V, V82L, L90M	Q58QE, T74P	L10I, I13V, K20I, L33V, E35D, M36I, N37T, I62V, L63P, I64IV, A71V, I93L	B
	CA4900	CA57629	GQ210592	IDV, APV	340	I54M, V82A	L10F	L33V, R41K, Q61QH, L63P	B
	CA9432	CA87353		SQV, NFV, RTV, IDV, LPV, TPV	504	M46IL, I54V, V82VL, I84V, L90M	V11I, G73T	T4S, I13V, L19V, K20IV, L33V, E35D, M36I, N37NS, K55R, R57K, L63P, I64V, C67F, H69R, A71I, I72F, P79A, I93L, T96S	B
Barber (2012)	76142	76142	JQ361676	LPV			Q58E	T12A, I13V, K14R, L33V, N37T, R41K, I62V, L63P, I64V, Q92E	B
Jones (2012)	132913	132913	JN669518	PI	NA			L33V, R41K, K45R, R57K, L63P, I64V, I93L	B
	141848	141848	JN669606	PI	NA			L33V, P39S, R41K, D60E, L63P, L89LM	B
	150413	150413	JN669749	PI	NA	L90M		T12S, I13V, K14R, K20I, L33V, E35D, M36I, N37S, R41K, D60E, I62V, L63Q, I64V, V82I, I93L	B
	162262	162262	JN670033	PI	NA			T12P, K14R, L33V, N37S, L63Q, I64V	B
	172414	172414	JN670287	PI	NA			L19T, L33V, N37C, I64V	B
	176192	176192	JN670388	PI	NA			T12N, L33V, R41K, L63T, I64V, I93L	B
	177680	177680	JN670457	PI	NA			L10V, G17E, K20KR, L33V, K45R, L63P, I64V, I93L	B
	177876	177876	JN670467	PI	NA			T12S, K14KR, L19LI, L33V, N37C, I64V, I72V	B
	193932	193932	JN670917	PI	NA			K14KR, L33V, N37C, R41K, I64V	B
Reynolds (2012)	E0716	E0716-2	JN652207	RTV, LPV				T12A, I13V, L33V, R41K, I64V	B

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