<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation L33V
Rx >= 1 PI
IncludeMixtures No
References 50
Patients 116
Isolates 129
 
Show mutation frequency as:
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Condra (1996)pt-HptHW12 IDV12V82T, L90MG73SI13V, L33V, N37C, I62V, L63P, A71V, I72MB
Molla (1996)RTV-203RTV203W32 RTV32  L33V, E35D, N37A, L63P, I64V, I93LB
Schmit (1996)JCSB7B7W78 RTV78I84V R8Q, L33V, E34K, E35D, N37T, R57K, L63P, I64VB
Patick (1998)503-213503-213W35 NFV35L90MG73SK20I, L33V, I62V, L63P, A71V, V77IB
Zolopa (1999)CA630CA3150AF085115SQV, IDV44  L33V, L63P, K70TB
Bacheler (2000)LB3-P25P25-0 IDV2  L33V, R41K, L63Q, I64V, E65DB
  P25-18 IDV20  L33V, R41K, L63Q, I64VB
Balotta (2000)CB-219CB-219AF252073SQV   L33V, L63P, H69Y, T74SB
Baxter (2000)GART-NG4GART-4 PI, NFVNAD30NL10LF, N88DI13V, L33V, E35D, M36I, I62IV, L63PB
 GART-NG70GART-70 PI, IDVNA  L33V, L63S, I64VB
Caride (2001)ERRJ01PROERRJ01AF165567SQV   L33V, N37C, I64V, G78RB
Cinque (2001)Pat1414csf_PostAF266539SQV, RTV8 I47ILL10I, I13V, G16E, L33V, E35D, N37T, R57K, I62V, L63T, I64V, C67QB
Eshleman (2001)A033AF357805AF357805NFV49  R8RP, T12S, I13V, L19I, K20R, L33V, R41I, R57K, D60E, L63P, I64V, V75VLB
 A096AF357778AF357778NFV10  L10V, I13V, K14KM, L19LI, L33V, R41RK, R57K, L63H, I64V, E65DB
  AF357825AF357825NFV50N88NS L10V, I13V, K14R, L19I, K20I, L33V, R57K, I62V, L63Q, I64V, E65D, T74S, I85ILB
Gonzales (2001)CA1457CA3891AY030593IDV, NFV47  L33V, N37S, R41K, I64V, I93LB
 CA3893CA9650AY030898IDV127  L10V, I13V, L33V, N37A, P39S, I64V, K70RB
 CA4097CA9767AY031089NFV85D30N L33V, E34D, M36V, K45Q, I64V, I72IMB
 CA4128CA9834AY031117IDV, NFV114D30NN88DI13V, K20T, L33V, I64V, A71VB
 CA4851CA12031AY031491Unknown, IDV>70  L10I, K14R, L33V, N37S, P39S, I62V, L63P, I64V, I93LB
 CA4900CA12098AY031540IDV56I54V, V82AL10FL33V, L63P, A71VB
Gibb (2002)DMG2222_w32 NFV32  T12N, L33V, N37C, I62V, L63P, I64L, H69QB
 DMG5656_w18 NFV19  L33V, N37C, L63Q, I64VB
 DMG5959_w52 NFV53  L33V, N37C, L63Q, I64VB
 DMG7171_w83 NFV83  L33V, N37C, L63Q, I64VB
Maguire (2002)SW32493SW32493 APV48M46I, I50V L10I, I13V, K14KR, L33V, E35ED, N37X, R41K, L63V, I64V, A71AV, I93LB
Margot (2002)MM-5539366585539366581 PINA  L10V, T12S, I13V, L33V, I64VB
 MM-4337368034337368031 PINA  K14R, L33V, N37T, P39S, R41K, D60E, I62IV, I64VB
 MM-2620366232620366231 PINA  I13V, L33V, I64VB
 MM-3521367593521367591 PINAD30NN88DL33V, E35D, M36I, R41K, L63P, I64V, V75IB
Masquelier (2002)apv4apv4M6AY133496NFV24D30NN88DT12V, L33V, N37A, R41K, R57K, D60E, L63PB
Tural (2002)368685368685 SQV, NFV126D30NN88DI13V, L33V, P39S, L63P, H69Q, A71I, I85VB
 881218881218 NFV102L90MG73SL10I, L33V, R41K, L63P, I93LB
Venturi (2002)GV-45GV-45.1AF517297IDV   L33V, N37C, R57K, I64VB
de Sa Filho (2003)BREPM029BREPM029AY182792IDV   L33V, R57K, L63PB
Monno (2003)ML_Pat27ML_Pat27 PINA  L10V, I13V, L33V, N37T, R41KL, L63Q, I64VB
Saah (2003)AS-43AS-43 NFV75  L33V, R41K, L63Q, I64VB
Shafer (2003)A384_31113111bEF548286NFV26D30N I13V, G17GW, K20T, L33V, L63P, H69KB
 A384_10921092bEF548445NFV, Unknown>31  I15V, G16GE, L19LI, L33V, N37A, R57K, I64VB
  1092c NFV, Unknown>31  I15V, G16E, L33V, N37A, R57K, I64VB
 A384_08420842bEF548466NFV34D30NN88NDL10V, T12I, I13V, L33V, N37S, R57K, L63PB
 A384_14781478bEF548892NFV23  L33V, E35D, N37S, L63P, I64V, V82VI, I93LB
 A384_45834583bEF549337NFV, Unknown>51  L33V, R41K, D60E, L63P, L89LMB
Wu (2003)CA630CA1200AF544412SQV, IDV, RTV84I84V, L90MG73GSL10I, K20KM, L33V, L63P, K70TB
Colonno (2004)RC-008-003-306003-30621 NFV56D30N T12S, I13V, K14T, L19V, L33V, M36I, N37S, K45Q, I64VB
Gomez-Carrillo (2004)9905599055AY365594PINA  L33V, N37S, L63C, I72V, L89MB
 119801119801AY365972PINA  T12K, I13V, G16E, L19I, L33V, N37S, P39S, I62V, L63H, I64V, I72IVB
 125287125287AY366044PINA  L10V, I13V, L33V, K45R, L63T, I64VB
Gulick (2004)RG369RG369w22 NFV3  L19I, L33V, N37T, Y59H, I64VB
 RG65RG65w47 ATV18  L33V, N37S, R41K, I64V, I93LB
Montes (2004)MB_patDAV00_DAVC705AJ577874IDV82  T12S, L33V, N37C, I64VB
 MB_patDAV C01_DAVC719AJ577875IDV, NFV115  T12S, L33V, M36V, N37C, Q61H, I64VB
Garcia-Bujalance (2005)GBS_02GBS_02AY872283RTV D30NN88DI13V, L33V, L63PB
 GBS_34GBS_34AY872315SQV, RTV, LPV I54V, V82CFIS, L90MQ58QE, G73GS, N88NDL10I, I13V, Q18H, K20M, L33V, N37T, I62V, L63P, A71V, C95LB
Kagan (2005)175848175848 PINAV32I, M46I, I47A, L90ML10F, L89VT4A, I13V, K20T, L33V, I62V, L63P, H69Y, A71V, I93LB
Ochoa de Echaguen (2005)B-0325B-0325AY833581IDV   T12S, L33V, L63P, I64V, H69K, I93LB
Rhee (2005)CA630CA3152AY796446SQV, IDV, RTV79I84V, L90MF53FL, G73GSL10I, K20KM, L33V, L63P, K70TB
 CA4097CA33349AY797016NFV233D30N I13V, L33V, E35D, M36V, K45Q, I64VB
 CA9649CA23560AY797782IDV, LPV134  I13V, L33V, N37S, P39S, I64VB
 CA9668CA33507AY797792NFV, Unknown>4  L33V, N37C, R41K, L63P, I93LB
 CA9725CA23833AY797826NFV27  K20KE, L33V, N37T, L63P, I93LB
 SWC-46704670-2338 SQV13  T12S, L33V, N37C, I64V, I93LB
  4670-2557 SQV, Unknown>23  T12S, L33V, N37C, I64V, I93L, C95XB
 CA14156CA33253AY797983NFV92M46MI G16E, L33V, M36I, P39S, I64V, I72VB
 CA14379CA34069AY798063LPV8  L33V, N37A, R57K, L63P, I64VB
  CA41378AY798064LPV43  L33V, N37A, R57K, L63P, I64VB
Baxter (2006)12-20772077-30609DQ876018PINAV32I, M46I, I47V, I54M, V82T, L90MV11IL10R, I13V, K20I, L33V, K55R, I62V, L63P, A71L, I72L, Q92RB
 12-17851785-30502DQ876077PINAM46I, I54M, L76V, I84V, L90ML10F, G73S, L89VI13V, Q18H, K20T, L33V, E35EDG, M36MI, N37NK, R57K, I62V, L63PS, A71V, I72LB
 12-13021302-30711DQ876209PINAM46I, I54V, I84V, L90ML10F, Q58E, G73S, L89VI13V, K20T, L33V, K55R, D60E, Q61DE, I64V, T91TSB
 12-20162016-30701DQ876694PINAD30N T12A, I13V, G16E, K20KT, L33V, E35D, N37Q, I62V, L63H, I64VB
 12-11961196-30912DQ879103PI, RTV, TPV>27M46I, I54A, I84V, L90MV11I, G73TL10I, I13V, Q18H, K20I, L33V, M36I, F53W, K55KR, L63P, I64V, A71V, I72ITB
 12-12451245-30318DQ877085PINAM46I, I47V, I54M, L76V, I84V, L90ML10F, V11VI, L89VI13V, G16A, K20M, L33V, K55R, I62V, L63P, A71VB
 12-12691269-30318DQ877136PINAM46I, I47V, I54M, L76V, I84V, L90ML10F, L89VI13V, G16A, K20M, L33V, K55R, I62V, L63P, A71VB
 48-18071807-30923DQ877437PINAI54M, I84V, L90MV11I, F53L, Q58QET12S, L19I, K20I, L33V, L63P, A71IB
 48-30483048-30319DQ877959PINAL90LIM T12TPS, I13IV, K14KR, L19LI, L33V, M36MI, N37ND, I62IV, L63P, A71AT, I72VB
 48-30553055-40212DQ877967PI, RTV, TPV>43V32I, M46I, I47V, L90ML89VR8Q, L10I, T12A, I13V, K20T, L33V, M36I, R41K, L63P, A71TB
 48-41704170-30407DQ878404PINA  L33V, N37S, R41K, I64V, I93LB
 48-42354235-30819DQ878467PINAL90LM L33V, N37C, Q61E, L63PB
 48-42414241-40707DQ878473PI, RTV, TPV>59M46I, I47V, I54AN88D, L89VL10I, I13V, Q18H, K20M, L33V, N37D, K55R, L63P, I66V, A71I, I72V, V77VI, Q92KB
 48-50225022-30606DQ878556PINAM46I, I54V, L76V, I84V, L90ML10F, V11I, Q58E, G73A, L89VI13V, K20I, L33V, E35K, M36I, K55R, D60E, I62V, L63P, I64V, A71V, T91S, I93LB
 48-60156015-30904DQ878614PI, RTV, TPV>24M46I, I54A, I84V, L90ML10FI, G73S, L89VV11L, I13V, K14KR, I15V, K20I, L33V, I62V, L63P, A71V, I72LB
  6015-40805DQ878613PI, RTV, TPV>72M46I, I54A, I84V, L90MK43KT, G73S, L89VL10IV, V11L, I13V, K14R, I15V, K20I, L33V, D60DE, I62V, L63P, A71V, I72LB
 48-61066106-30618DQ878698PINAV32I, M46I, I47V, I84V, L90MG73GA, T74TPL10V, I13V, K20M, L33V, N37D, L63P, H69KB
 48-70507050-30429DQ878921PINA  I13IV, L33V, P39S, L63PB
 48-71027102-30728DQ878955PINAM46MI, I47A, I84V I13V, K20KT, L33V, N37C, R57K, L63P, I64VB
  7102-40225DQ878956PI, RTV, TPV>30M46I, I47A, I84V L10V, I13V, K20T, L33V, M36I, N37C, R57K, L63P, I64VB
 48-71617161-30609DQ878999PINA  L10V, T12V, K14R, L33V, N37D, L63P, Q92QKB
 48-92049204-30916DQ877581PINA  L33V, L63P, I64V, V77IB
 48-91029102-30908DQ877691PINAM46I, I54V, I84V, L90MG73SL10I, Q18H, L19P, K20I, L24F, L33V, M36I, N37S, I62V, L63P, H69L, A71T, I72R, I93MB
 48-80188018-30729DQ879063PINAM46L, I54V, V82AL24I, F53LL10I, I13V, K20T, L33V, L63P, I64VB
Mitsuya (2006)CA4128CA33490DQ780906IDV, NFV, SQV, RTV266D30N, I54IL, I84V, L90LML10F, N88DI13V, K20T, L33V, I64V, A71VB
Rhee (2006)CA4900CA37763 IDV, APV229I54M, V82AL10FL33V, R41RK, L63PB
Santos (2006)PA342PA342DQ344012IDV, RTV, LPV156  L33V, N37S, R41K, I64V, I93LB
McGrath (2007)10DMG_10a ATV48  L10LI, I13IV, L33V, N37X, R41RK, I62V, L63APS, I64V, C67CY, H69HQB
von Wyl (2007)2697745EF449969PINAD30N T12S, I13V, K14T, L19V, L33V, M36I, N37S, K45Q, I64VB
Riddler (2008)RG11340RG11340w131 LPV131  T12P, I13V, L33V, I62V, L63S, I64V, Q92EB
 RG13005RG13005w118 LPV118  L33V, W42Y, L63P, I64V, H69Y, I72VB
 RG31923RG31923w67 LPV67 K43TT12P, I13V, L33V, L63S, I64V, C67YB
 RG83358RG83358w32 LPV26  L33V, L63P, A71T, I72EB
 RG86088RG86088w73 LPV48  L33V, N37C, R41K, L63Q, I64V, E65EDB
 RG90663RG90663w99 LPV94  L10I, T12S, I13V, L19I, L33V, I62V, L63LS, I64V, C67YB
Cardoso (2009)3145BRGO3145FJ638465PINA  L33V, N37S, R41K, L63P, I64V, H69K, I93LB
Dumans (2009)RENA573RENA573FJ405090IDV66  I13V, K14R, L33V, N37E, R57K, L63LP, I64V, K70R, I72T, I93ILB
Rhee (2009)CA14311CA64023FJ983359APV, RTV, ATV, LPV369V32I, M46IV, I47V, I54M, I84V, L90ML10F, V11I, G73T, L89VI13V, L19Q, K20M, L33V, E35A, M36I, R57K, I62V, L63P, I64V, T74AB
 CA21076CA48465FJ983484NFV338D30N L33V, K45I, A71VB
Thomson (2009)SP_B_053RU_SP_B_053FJ009810LPV24  L33V, N37Y, I62V, L63P, I64L, H69QB
Dau (2010)06164A06164AGU581711PINA  I13V, L33V, N37D, R41K, L63P, I66V, A71T, I93LB
 08059A08059AGU581891PINAL90LM L10V, I13V, K20KT, L33V, K43KR, I62IV, I64V, T74TSB
 08588A08588AGU581927PINAV32I, I47V, I54LL10FI13V, K20T, L33V, L63P, I64VB
 09540A09540AGU581974PINA  L33V, L63S, I64VB
 10775A10775AGU582018PINAM46IN88TL10I, I13V, L33V, N37D, I62VB
Rangel (2010)HIV270bHIV270bGU807524PINAI84IV, L90ML10LF, V32VL, L89VI13V, K20KT, L33V, E34EQ, N37C, R41RK, Q61QH, I62IV, L63P, I66IV, A71AT, I93IL, C95CF, F99FCB
Rhee (2010)CA3972CA68568GQ212298IDV, SQV, NFV, RTV, APV, ATV, TPV599M46I, I54V, V82L, L90MQ58QE, T74PL10I, I13V, K20I, L33V, E35D, M36I, N37T, I62V, L63P, I64IV, A71V, I93LB
 CA4900CA57629GQ210592IDV, APV340I54M, V82AL10FL33V, R41K, Q61QH, L63PB
 CA9432CA87353 SQV, NFV, RTV, IDV, LPV, TPV504M46IL, I54V, V82VL, I84V, L90MV11I, G73TT4S, I13V, L19V, K20IV, L33V, E35D, M36I, N37NS, K55R, R57K, L63P, I64V, C67F, H69R, A71I, I72F, P79A, I93L, T96SB
Barber (2012)7614276142JQ361676LPV  Q58ET12A, I13V, K14R, L33V, N37T, R41K, I62V, L63P, I64V, Q92EB
Jones (2012)132913132913JN669518PINA  L33V, R41K, K45R, R57K, L63P, I64V, I93LB
 141848141848JN669606PINA  L33V, P39S, R41K, D60E, L63P, L89LMB
 150413150413JN669749PINAL90M T12S, I13V, K14R, K20I, L33V, E35D, M36I, N37S, R41K, D60E, I62V, L63Q, I64V, V82I, I93LB
 162262162262JN670033PINA  T12P, K14R, L33V, N37S, L63Q, I64VB
 172414172414JN670287PINA  L19T, L33V, N37C, I64VB
 176192176192JN670388PINA  T12N, L33V, R41K, L63T, I64V, I93LB
 177680177680JN670457PINA  L10V, G17E, K20KR, L33V, K45R, L63P, I64V, I93LB
 177876177876JN670467PINA  T12S, K14KR, L19LI, L33V, N37C, I64V, I72VB
 193932193932JN670917PINA  K14KR, L33V, N37C, R41K, I64VB
Mollan (2012)MK59MK59w23 RTV, ATV23  I13V, L33V, E35ED, N37X, R57K, L63P, C67E, I72VB
Reynolds (2012)E0716E0716-2JN652207LPV   T12A, I13V, L33V, R41K, I64VB
Grossman (2014)10911091KF134940NFV, LPV52  L33V, N37Y, I62V, L63P, I64L, H69QB
 779779KC213703LPV52  K14R, L33V, N37Y, I62V, L63P, I64L, H69QB