Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	B
Gene	PR
Mutation	L33I
Rx	PI-naive
IncludeMixtures	No

References	64
Patients	172
Isolates	183

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Hammer (1997)	ACTG320_1000	1000		None	L33I	E35D, N37S, L63P, V77I	B
	ACTG320_354	354		None	L33I	N37AS, L63P	B
	ACTG320_531	531		None	L33I	T12*AES, R41K, L63HN, A71V, I72M, I93L	B
	ACTG320_627	627		None	L33I	N37S, I62V, L63P, H69Q	B
	ACTG320_92	92		None	L33I	K43R, L63P, I93L	B
Zhang (1997)	7DiBV	7DiBV0		None	L33I	K14R, I62V, L63P, A71T, I93L	B
Murphy (1999)	ACTG347_0039	039_PR_w0		None	L33I	T12P, L19I, N37S, L63P, I64IL, H69N, A71V, P79S, R87RS, I93L	B
Bacheler (2000)	LB3-P9	P9-0		None	L33I	L10I, L19I, N37S, R41K, I62V, L63P, H69Y, I93L	B
	LB4-P133	P133-0		None	L33I	N37S, L63P, H69Y	B
		P133-40		None	L33I	N37S, L63P, H69Y	B
	LB4-P134	P134-0		None	L33I	L10P, P39Q, L63P, H69Y, R87G	B
		P134-12		None	L33I	P39Q, L63P, H69Y	B
	LB5-P165	P165-0		None	L33I	N37E, I62V, L63P, A71T	B
Albrecht (2001)	ACTG364_308	308		None	L33I	Q18L, L19I, N37S, L38F, R41K, L63P, H69HY, Q92K	B
Gonzales (2001)	CA1801	CA4839	AY030719	None	L33I	L10LI, I13V, N37S, L38LF, I62IV, L63P, I64V	B
	CA3990	CA9591	AY030989	None	L33I	M36I	B
Kijak (2001)	ARG-64	ARG-64	AF329606	None	L33I	E35D, N37H, R41K, K43R, L63P, I64V, I93L	B
Perno (2001)	PCF_Pat105	PCF420	AF376538	None	L33I	K14R, M36L, Q61E, L63P, I64V, I93L	B
Cuevas (2002)	CU27	CU27	AF425408	None	L33I	N37S, R41K, A71V, I93L	B
Hanna (2003)	HG048	HG048	AY049633	None	L33I	Q18L, N37C, R41RK, R57RK, I62V, L63AP, A71AT, I72IV, V77I, I93L	B
	HG083	HG083	AY049563	None	L33I	R41K, L63Q, K70Q, A71T, I72IM, V77I, I93L	B
Shafer (2003)	A384_0242	0242a	EF548203	None	L33I	N37S, L63P, L89M, I93L	B
	A384_0910	0910a	EF548335	None	L33I	T12TI, R41K, A71AT, V77VI, I93L	B
	A384_3179	3179a	EF548362	None	L33I	I13V, I15L, L63P	B
	A384_0555	0555a	EF548808	None	L33I	Q18QE, L19I, E35ED, N37AGST, R41RK, K45KR, L63P, V77I, I93L	B
	A384_0569	0569a	EF548838	None	L33I	N37D, R41K, R57RK, L63S, I64L, A71V, I72AT, V77VI, I93L	B
	A384_1499	1499a	EF548885	None	L33I	L63P, C67S, H69Y	B
	A384_0798	0798a	EF549059	None	L33I	L10V, T12TA, I13V, N37S, P39Q, R57RK, L63P, I64V	B
Vaughan (2003)	VHE_Pat4	VHE101prrt	AY267297	None	L33I	I15L, L19I, L63P, I93L	B
Gulick (2004)	RG511	RG511w0		None	L33I	I13IV, K14KR, Q18QL, M36MIT, R41K, D60E, L63P, I64IV, H69KQ	B
	RG83	RG83w0		None	L33I	L10V, T12TA, I13V, N37CS, P39Q, R57RK, L63P, I64V, V77VI	B
		RG83w145		None	L33I	L10V, T12S, I13V, N37S, P39Q, L63P, I64V, V77I	B
		RG83w157		None	L33I	L10V, T12S, I13V, N37S, P39Q, L63P, I64V, V77I	B
Kuritzkes (2004)	KDR_pat36	A0036	AY527853	None	L33I	E21EG, I62IV, L63ST, A71T, V77I, V82I	B
		A0037	AY527854	None	L33I	E21EG, I62IV, L63ST, A71T, V77I, V82I	B
	KDR_pat242	A0323	AY528140	None	L33I	G16E, K20KR, M36MI, I62IV, L63AP, I93IL	B
		A0324	AY528141	None	L33I	G16E, K20KR, M36MI, I62IV, L63AP, I93IL	B
		A0325	AY528142	None	L33I	G16E, K20KR, M36MI, I62IV, L63AP, I93IL	B
		A0327	AY528144	None	L33I	G16E, I62IV, L63AP, I93IL	B
		A0326	AY528143	None	L33I	I13IT, K14KHNQ, G16E, I62IV, L63AP, I93IL	B
Machado (2004)	N29	N29	AY569865	None	L33I	I13V, G17E, R41K, D60E, I62V, L63P, H69Y, I72R	B
Pariente (2004)	pt7	7	AY315956	None	L33I	Q2*, L5LF, I15L, T31TP, Y59YF, L63P, I93L	B
Rhee (2005)	CA16493	CA39173	AY798260	None	L33I	L63P, A71T, I72E, V77I	B
Vazquez de Parga (2005)	RU01068	RU01068	EU345769	None	L33I	M36I, R41RK, D60E, L63S, I72V, I93L	B
	RU01077	RU01077	EU345774	None	L33I	N37S, L63S, H69Y	B
	RU99028	RU99028	EU345790	None	L33I	V11L, D25Y, I62V, L63P, H69Y	B
Jayaraman (2006)	1-00-0002	1-00-0002		None	L33I	L10I, L63P, I93L	B
	1-00-0077	1-00-0077		None	L33I	N37T, L63P, I93L	B
	2-00-0499	2-00-0499		None	L33I	N37S, P39S, L63P, H69Y, A71T, V77I, I93L	B
	2-00-0544	2-00-0544		None	L33I	I13V, N37S, L63P, E65D, V77I	B
	2-00-0548	2-00-0548		None	L33I	N37S, P39S, R41K, D60E, L63P, A71T, I93L	B
	2-01-0026	2-01-0026		None	L33I	N37C, P39S, R41K, L63P, A71T, I93L	B
Lama (2006)	Pt6128	6128		None	L33I	L10I, V11T, N37D, R57K, Q61E, I62V, L63P, I64L, A71V, V77T, I93L	B
Petroni (2006)	AP_ARRP047	AP_ARRP047	DQ345511	None	L33I	T12S, L19Q, N37R, P39E, R41K, D60E, Q61E, I62V, L63P, A71T, V77I, P79D, I93L	B
Tsuiji (2006)	KT_OK1160	KT_OK1160	AY917160	None	L33I	N37T, L63S, I64V	B
Brumme (2007)	1448	PRRT_1448	EF368758	None	L33I	I13V, N37S, L63P, V77I	B
	1488	PRRT_1488	EF368798	None	L33I	I13V, R41K, D60E, Q61E, L63P, A71T, I93L	B
	1513	PRRT_1513	EF368823	None	L33I	I13V, K14KR, G16GE, P39S, R41K, D60E, L63P, I64V	B
	1577	PRRT_1577	EF368887	None	L33I	M36MI, K43KR, L63PT, E65EA, A71AV, I93L	B
	1578	PRRT_1578	EF368888	None	L33I	M36I, N37D, I64V, E65D	B
	1619	PRRT_1619	EF368929	None	L33I	T12A, I13V, G16E, N37S, P39S, R41K, D60E, L63P, I64V	B
	1727	PRRT_1727	EF369037	None	L33I	G17E, Q18QH, N37S, L63P, A71T, V77I, I93L	B
	1822	PRRT_1822	EF369132	None	L33I	E35ED, N37S, P39S, R41RK, R57K, L63P, A71AT	B
Dilernia (2007)	N48	N48	EF120305	None	L33I	K14R, L19LI, P39Q, R41K, L63P, A71AITV, I93L	B
Gatanaga (2007)	B04-511003-1	B04-511003-1	AB640087	None	L33I	L10I, K14R, N37A, R41K, D60E, L63C, H69Y, I93L	B
	F04-5110-4	F04-5110-4	AB640603	None	L33I	T12A, R57K, L63P, A71T, I93L	B
Holguin (2007)	588503	588503	EF583201	None	L33I	K14R, I62V, L63P, G68E, A71V, V77I, I93L	B
	591871	591871	EF583213	None	L33I	T12P, K14R, N37T, P39S, L63P, C67D, A71V, V77I, I93L	B
Sanchez Onoro (2007)	588503	588503		None	L33I	K14R, I62V, L63P, G68E, A71V, V77I, I93L	B
	591871	591871		None	L33I	T12P, K14R, N37T, P39S, L63P, C67D, A71V, V77I, I93L	B
	112102	112102		None	L33I	R57RK, D60DE, Q61QE, L63P, I64L, A71T, I72V	B
	637706	637706		None	L33I	T12P, K14R, N37T, P39S, L63P, C67D, A71V, V77I, I93L	B
Vicenti (2007)	LR_102	36382	EF376461	None	L33I	N37S, R41K, D60E, Q61E, L63P, V77VI, I93L	B
	3334	41008R	EF376577	None	L33I	T12P, K14R, N37S, R41K, D60E, Q61E, L63P, I72IV, V77VI, I93L	B
Bang (2008)	079	BJH_079	EF157935	None	L33I	I3V, L10I, N37S, L63P, I64*, C67DE, A71AT, I72V, I93L	B
Chang (2008)	TW5833a	TW5833a		None	L33I	I13V, E35D, M36I, P39S, R41K, I62V, L63P, A71V, I72IV, V77I, I93L	B
Holguin (2008)	SP39-328862	SP39-328862	EU255412	None	L33I	R41K, L63P, A71T, V77I, I93L	B
	SP57-289976	SP57-289976	EU255430	None	L33I	T12X, N37T, P39S, L63P, A71V, I72IT, V77I, I93L	B
	SP21-349998	SP21-349998	EU255506	None	L33I	G16GE, E35D, N37NS, L63Q, I64V, V77I	B
Jacobs (2008)	1607	1607	EF602179	None	L33I	I13V, K14R, N37S, R41K, L63S, I64V, V77I, I93V	B
Lloyd (2008)	TX115	03HN_TX115	EU312846	None	L33I	N37C, L63P, I64V, V82I, I93L	B
	TX175	03HN_TX175	EU312913	None	L33I	T12I, G16E, A22V, M36MIT, P39S, I62V, L63Q, I64V, I72IV	B
McConnell (2008)	NV61	NV61	EU288146	None	L33I	L5V, E35D, N37S, L63Q, I64V, V77I	B
Miura (2008)	BEC117	BEC117	EU517902	None	L33I	E35D, N37E, L63P, A71T, V77I, I93L	B
Palacios (2008)	12452	12452		None	L33I	E35ED, N37CS, I62V, L63A, A71T, V77I, I93L	B
Brown (2009)	CAS_164_1_8084	CAS_164_1_8084	FJ030709	None	L33I	I15V, N37D, P39PS, L63P, A71T, I72M	B
Brumme (2009)	K1573	K1573	GQ371958	None	L33I	N37T, I62V, L63P, I64V, V77I, I93L	B
	K6570	K6570	GQ371967	None	L33I	N37S, P39S, R41K, L63Q, A71T, I93L	B
	PRRT_4118	PRRT_4118	GQ303807	None	L33I	M36MI, N37S, R41K, L63P, I93L	B
Cardoso (2009)	BRGO3002	BRGO3002	FJ548787	None	L33I	L19LI, N37AGST, L63P, C67S, H69HY	B
	BRGO3094	BRGO3094	FJ594153	None	L33I	G17D, P39Q, R41K, R57K, D60E, Q61K, I62V, L63P, I64V, A71T, I93L	B
	BRGO3143	BRGO3143	FJ594177	None	L33I	G17DE, N37S, R41K, D60E, L63P, A71T, I93L	B
Cuevas (2009)	P1091	P1091.1	EU822568	None	L33I	K14R, N37D, L63P, I93L	B
	P1152	P1152.1	EU822586	None	L33I	T12A, I13IV, E34Q, N37S, P39Q, R57K, I62V, L63A, I64V	B
	P1213	P1213.1	EU822601	None	L33I	T12P, N37T, P39S, L63P, C67Y, A71V, V77I, I93L	B
	P1530	P1530.1	EU822693	None	L33I	I13V, P39S, I62IV, L63LP, A71V, V77I, I93L	B
	P1565	P1565.1	EU822701	None	L33I	T12TI, I15L, L19I, E35D, N37D, L63P, I64V, H69Y, P79S	B
De Meyer (2009)	LPV55	LPV55BL		None	L33I	I62V, L63P, A71T, V77I, I93L	B
de Sa-Filho (2009)	55687	55687Cub	GQ294598	None	L33I	L10I, M36I, R41K, L63P	B
Smith (2009)	PI4	US2003PI4		None	L33I	L63P, I64IL, V77VI, I93L	B
	PI182	US2003PI182		None	L33I	I13V, N37T, L63S, I64V, E65D, V77I	B
	CR231	US2007CR231		None	L33I	K14R, N37S, R41K, K45KR, L63P, V77VI, I93L	B
Vercauteren (2009)	pt2178	162007932	GQ398846	None	L33I	L10I, N37S, P39PS, R41K, I62V, L63P, I64IV, C67S, G68GV, I93L	B
	pt1872	2030788126	GQ399152	None	L33I	N37Y, I62V, L63A, H69Q, K70E, A71T, V77I, I93L	B
	pt1844	2233747325	GQ399180	None	L33I	N37T, R41K, L63P, I93L	B
	pt1689	3207458117	GQ399335	None	L33I	I13V, M36T, N37Q, P39S, I62IV, L63P	B
	pt1542	3YT1dhFIbx	GQ399482	None	L33I	I13V, L63P, A71T, I93L	B
	pt1525	4109419986	GQ399499	None	L33I	W6L, N37NT, P39S, L63P, A71V, V77I, I93L	B
	pt1072	6795753306	GQ399952	None	L33I	N37E, P39S, R57K, D60E, A71T, V77I, I93L	B
	pt986	7344543899	GQ400038	None	L33I	K14KR, N37S, P39P*QS, R41K, I62V, L63P, A71T, V77I, I93L	B
	pt664	9029928761	GQ400360	None	L33I	N37NT, P39S, L63P, A71V, V77I, I93L	B
Wang (2009)	F762P	F762P	FJ469735	None	L33I	N37S, R41K, D60E, I64V, I93L	B
	PRLS19	PRLS19	FJ469763	None	L33I	N37S, R41K, D60E, L63P, C67S	B
Yu (2009)	056	07CNGD056	FJ387080	None	L33I	E35D, R41K, D60E, L63P, I93L	B
Bonura (2010)	1162_26	1162_26	GU969531	None	L33I	N37CS, P39PQ, R41RK, L63P, A71T, V77I	B
Ragonnet-Cronin (2010)	PHAC_101	PHAC_101	HM468599	None	L33I	L63P, V82I, I93L	B
	PHAC_108	PHAC_108	HM468606	None	L33I	M36MI, R57RK, I62V, L63P, I93L	B
	PHAC_301	PHAC_301	HM468799	None	L33I	N37C, R41K, R57RK, L63P, A71T, V77VI, I93L	B
	PHAC_313	PHAC_313	HM468811	None	L33I	I13V, K14R, G16E, P39S, R41K, D60E, Q61E, L63P, I64V	B
	PHAC_379	PHAC_379	HM468877	None	L33I	Q2K, G16GE, N37C, P39S, R41K, K45R, L63P, A71T, I93L	B
	PHAC_796	PHAC_796	HM469294	None	L33I	K20R, L63P, I93L	B
Yebra (2010)	249432	05SP0249432	FJ481764	None	L33I	T12P, K14R, N37T, P39S, L63P, C67D, A71V, V77I, I93L	B
	256086	05SP0256086	FJ481778	None	L33I	N37T, P39S, L63P, C67Y, A71V, V77I, I93L	B
	29659	06SP029659	FJ481815	None	L33I	N37S, R41K, L63T, A71T, I93L	B
	321473	06SP0321473	FJ481861	None	L33I	L10LI, N37T, P39S, R41K, L63P, C67D, A71V, V77I, I93L	B
Chibo (2011)	S20	S20	JF895207	None	L33I	R41K, L63P, A71T, V77I, I93L	B
	S22	S22	JF895209	None	L33I	N37C, Q61E, L63P, I64L, I93L	B
	S64	S64	JF895251	None	L33I	L19LI, M36MI, N37S, P39S, R41K, Q61H, L63P, V77I, I93L	B
	S97	S97	JF895284	None	L33I	N37C, Q61E, L63P, I93L	B
	S134	S134	JF895321	None	L33I	L10I, K20R, M36I, N37S, L63P, I93L	B
	S152	S152	JF895339	None	L33I	R41RG, K43KN, L63Q, I64V, E65D	B
	S181	S181	JF895368	None	L33I	E35D, M36I, L63P	B
	S190	S190	JF895377	None	L33I	R57K, L63Q, I64V, I93L	B
	S193	S193	JF895380	None	L33I	L10I, K20R, M36I, N37S, Q61E, L63P, I93L	B
Kao (2011)	Pat061	36558	HQ657979	None	L33I	I13V, E35D, M36I, P39S, L63P, A71V, V77I, I93L	B
Sanabani (2011)	BR2033	BR2033	JN692440	None	L33I	E35D, M36I, N37A, R41K, L63P, I64L, I93L	B
Avila-Rios (2012)	JS00M91PTR	JS00M91PTR	KC169137	None	L33I	K14KR, I15V, L19T, K20R, M36I, R41K, I62V, L63P, I93L	B
	Y000MCJHSY	Y000MCJHSY	KC169753	None	L33I	E35D, R41I, Q61QR, L63P, A71T, I72E, V77I, I93L	B
	D200FF6CUV	D200FF6CUV	KC168388	None	L33I	N37S, R41K, I62V, L63H, A71V, T74A, I93L	B
	J100M66HTA	J100M66HTA	KC169012	None	L33I	I15V, L19T, K20R, M36I, N37NHRS, P39PS, R41K, I62V, L63P, A71AT, I93L	B
De Gascun (2012)	IRL04486	IRL04486	JN622425	None	L33I	W6WC, M36MI, N37S, P39S, R41RK, L63P, A71AT, V77VI	B
	IRL20062	IRL20062	JN622545	None	L33I	I13V, M36T, N37S, L38LR, P39S, I62V, I64V	B
	IRL14538	IRL14538	JN622731	None	L33I	E35D, N37HY, I62V, L63P, I64L, H69Q, K70E, A71T, V77VI, I93L	B
	IRL61052	IRL61052	JN622805	None	L33I	I13V, N37C, R41K, L63S, I64V, H69Y, V77I	B
Delwart (2012)	479-9180-8	479-9180-8	JN215067	None	L33I	L19Q, R41K, L63A, A71T	B
	476-9723-2	476-9723-2	JN215126	None	L33I	E35D, R41K, L63P, A71T, I93L	B
Escobar (2012)	ES78	ES78	JX466954	None	L33I	E35K, M36I, N37S, R41K, L63P, E65D, H69Y, K70R, I72V	B
	ES138	ES138	JX467004	None	L23I, L33I	L19I, E35K, M36I, N37S, R41K, L63P, E65D, H69Y, K70R, I72V	B
	ES141	ES141	JX467005	None	L33I	E35K, M36I, N37S, R41K, L63P, E65D, H69Y, K70R, I72V	B
Machado (2012)	CUPL1033	CUPL1033	JN000005	None	L33I, Q58E	M36T, P39S, R57K, I62V, L63P, I64V	B
	CUPL1035	CUPL1035	JN000007	None	L33I	R41K, L89M	B
	CUPL1036	CUPL1036	JN000008	None	L33I	I3F, I13V, P39S, I62V, L89M	B
	CUPL1044	CUPL1044	JN000016	None	L33I, Q58E	I13V, M36T, P39S, R57K, I62V, L63P, I64V	B
	CUPL1076	CUPL1076	JN000048	None	L33I, Q58E	I13V, M36T, P39S, I62V, L63F, I64V	B
	CUPL1102	CUPL1102	JX194181	None	L33I	V11F, D25E, P39S, I62IV, L89M	B
	CUPL1119	CUPL1119	JX194198	None	L33I	K43I, L63A, E65D, A71T, I72V, R87P, T91N	B
	CUPL1137	CUPL1137	JX194216	None	L33I, Q58E	I13V, M36T, P39S, R57K, I62V, L63P, I64V	B
Murillo (2012)	31164	31164	KC412822	None	L33I	L63C, V77I, P79PS, I93L	B
Ragonnet-Cronin (2012)	A10_096	A10_096	JX014718	None	L33I	T12S, I13V, L19I, N37H, L63S, I64V	B
	B07_192	B07_192	JX014924	None	L33I	T12TA, I13V, K14R, E35ED, N37S, R57K, L63P, I64V	B
	C07_060	C07_060	JX015012	None	L33I	I13V, R41K, D60E, Q61E, L63PS, A71T, I72T, I93L	B
	F06_054	F06_054	JX015079	None	L33I	M36I, N37S, R41K, L63C, A71V, I93L	B
	F06_111	F06_111	JX015092	None	L33I	T12TP, I13V, K14R, R41K, D60E, Q61E, L63P, A71T, I93L	B
	F09_210	F09_210	JX015103	None	L33I	M36I, N37NS, R41K, L63C, A71V, I93L	B
Ragonnet-Cronin (2012)	PHAC08_215	PHAC08_215	JQ674857	None	L33I	L19V, N37C, R41K, D60E, L63S, I64V	B
	PHAC07_327	PHAC07_327	JQ674999	None	L33I	M36IT, L63P, I93L	B
	PHAC08_173	PHAC08_173	JQ675117	None	L33I	M36I, N37S, R41K	B
	PHAC09_125	PHAC09_125	JQ675248	None	L33I	I13V, K20KQ, M36I, N37G, P39S, R41K, D60E, I62V, I64V	B
Yang (2012)	GZ079	GZ079	JN848940	None	L33I	R41K, D60E, L63P, I72V, I93L	B
Alencar (2013)	RJ2-0017	RJ2-0017	JQ238050	None	L33I	L19I, N37NS, R41K, L63P, A71V, V77I, Q92QE, I93L	B
Ferreira (2013)	BR09SP374	BR09SP374	HM534037	None	L33I	I13V, K14KR, N37C, R41RK, L63Q, I64V, A71V, I72E, V77I, I93L	B
Frentz (2013)	EHR-07973	EHR-07973	JX299671	None	L33I	N37S, R41K, L63A, A71T, I93L	B
	EHR-12881	EHR-12881	JX299746	None	L33I	N37S, L63LP, I64L, I93L	B
	EHR-27005	EHR-27005	JX300007	None	L33I	I13V, N37C, R41K, L63S, I64V, H69Y, V77I	B
	EHR-34890	EHR-34890	JX300128	None	L33I	N37NSTY, P39PS, R41K, L63P, A71T, V82VI, I93L	B
	EHR-52450	EHR-52450	JX300410	None	L33I	N37T, R41K, L63P, V82VI, I93L	B
	EHR-546616	EHR-546616	JX300449	None	L33I	N37T, R41K, L63P, I93L	B
	EHR-58182	EHR-58182	JX300511	None	L33I	R41K, I62V, L63PS, I64IV, I72M, V77I, I85V	B
	EHR-721219	EHR-721219	JX300762	None	L33I	I13V, K20R, N37T, L63P, I64V	B
	EHR-79741	EHR-79741	JX300901	None	L33I	K20R, M36I, N37T, R41K, L63P, I93L	B
	EHR-91496	EHR-91496	JX301071	None	L33I	E35D, N37D, R41K, Q58K, L63P, I93L	B
	EHR-96012	EHR-96012	JX301123	None	L33I	N37T, R41K, L63P, H69NY, V82VI, I93L	B
	EHR-96732	EHR-96732	JX301131	None	L33I	N37T, R41K, L63P, V82VI, I93L	B

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