Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	L33I
Rx	>= 1 PI
IncludeMixtures	No

References	39
Patients	180
Isolates	213

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Condra (1996)	pt-P	ptPW48		IDV	48	M46I, V82F, I84V	L33I	L10I, T12S, I13V, M36I, I64V, L89M	B
	pt-J	ptJW24		IDV	24	I54V, V82F	L33I	L10I, Q18E, K20R, E35D, M36I, N37S, L63P, L89M, I93L	B
		ptJW32		IDV	32	I54V, V82F	L33I	L10I, Q18E, K20R, E35D, M36I, N37S, D60E, L63P, L89M, I93L	B
		ptJW36		IDV	36	I54V, V82F, L90M	L33I	L10I, Q18E, K20R, E35D, M36I, N37S, L63P, L89M, I93L	B
Zhang (1997)	7DiBV	7DiBV2		IDV	2		L33I	K14R, I62V, L63P, E65R, A71T, I93L	B
		7DiBV6		IDV	6		L33I	K14R, I62V, L63P, A71T, I93L	B
		7DiBV9		IDV	9	L90M	L33I, G73S	K14R, I62V, L63P, A71T, I93L	B
		7DiBV19		IDV	19	M46I, L90M	L33I, G73S	I13V, K14R, M36I, I62V, L63P, A71T, I93L	B
		7DiBV30		IDV	30	V82A, L90M	L33I, G73S	L10I, I62V, L63P, A71V, I93L	B
		7DiBV41		IDV	41	V82A, L90M	L33I, G73S	L10I, I62V, L63P, A71V, I93L	B
		7DiBV49		IDV	49	V82A, L90M	L33I, G73S	L10I, I62V, L63P, A71V, V77I, I93L	B
		7DiBV60		IDV	60	V82A, L90M	L33I, G73S	K14R, I62V, L63P, A71V, I93L	B
Zolopa (1999)	CA1251	CA23169	AY798348	SQV, RTV, IDV, Unknown	>164	V32I, M46I, I47V, I84V, L90M	L10F, L33I, N88D	I13V, E35D, M36I, R41K, L63P, I66V, A71V	B
		CA23171	AY798349	SQV, RTV, IDV, Unknown	>164	V32I, M46I, I47V, I84V, L90M	L10F, L33I, N88D	I13V, E35D, M36I, R41K, L63P, I66V, A71V	B
Bacheler (2000)	LB4-P134	P134-65		IDV	12	M46I	L33I, N88D	P39Q, L63P, H69Y, A71T	B
Baxter (2000)	GART-NG81	GART-81		PI, IDV	NA	V82VF, L90LM	L33I, Q58QE	I3IV, L10I, I13V, E35ED, L63V, A71T, I93L	B
	GART-NG109	GART-109		PI, IDV	NA	I54V, V82A	L33I	K20R, M36I, R41K, I62V, L63T, I64V, I85V	B
Belec (2000)	r58	r58_m12	AF204375	IDV	58	M46I	L33I	L10V, I13V, M36I, R57K, L63P, I64V, I93L	B
Falloon (2000)	JF02	JF02-0w	AF227689	IDV, RTV, SQV	124	M46I, I54V, V82A, L90M	L33I, G73S	L10I, K14R, E35D, M36I, I62V, L63P, A71V, I93L	B
		JF02-8w	AF227690	IDV, RTV, SQV, APV	132	M46MI, V82A, L90M	L33I, G73S	L10I, K14KR, L24LF, M36I, I62V, L63P, A71V, I93L	B
Rousseau (2000)	MNR1	MNR1	AJ405947	IDV, SQV, RTV, NFV	97	I84V, L90M	L33I, G73S	L10I, I13V, E35D, M36I, N37D, L63P, A71V, I72L, V77I	B
	MNR13	MNR4705	AJ405958	IDV, SQV, RTV, NFV	94	M46I, N88S, L90M	L33I, Q58E	L10V, T12P, I13V, K14R, K20T, M36I, I62V, L63P, H69H_NGQCV, A71T, I72T, I93L	B
Eshleman (2001)	A088	AF357774	AF357774	NFV	12		L33I	Q7D, I13V, I15IL, L63P, I64V, I72M	B
Gonzales (2001)	CA1294	CA3223	AY030512	NFV	67	D30DN	L33I	I13V, K20KT, E35ED, M36I, N37D, L63P	B
	CA1454	CA3882	AY030590	IDV, NFV	117		L33I	L63P, A71AV, I72E, I93L	B
	CA3914	CA9457	AY030917	NFV	77	M46I	L33I, T74P	L10LI, R41K, I62V, L63P, A71T, I72V, V77I, I93L	B
	CA3958	CA9508	AY030956	IDV, SQV, NFV	55	I54V, V82A, L90M	L33I, Q58E	L10I, E35D, M36I, I62V, L63P, A71V, T74K	B
	CA3970	CA9732	AY030968	IDV, NFV	140	D30N	L33I	R41K, L63P, I93L	B
	CA4034	CA9684	AY031029	SQV, IDV, RTV, NFV	139	I84IV, L90M	L10F, L33I, G73S	E35D, M36I, P39Q, I62V, L63P, A71V, V82I	B
	CA4299	CA10690	AY031165	IDV, NFV	182	M46I, I84V, L90M	L33I, G73S	L10I, K14R, L19I, K20I, M36I, R41RK, L63P, I64V, A71V, I93L	B
	CA4328	CA10728	AY031192	IDV, SQV, RTV	90	I84V, L90M	L10F, L33I, G73S	T4A, L19I, E35D, M36I, R57K, L63P, A71V, I72F, I85V	B
	CA4566	CA11217	AY031363	IDV	168	M46I, I54V, V82A	L10F, L33I	N37C, K43KN, K55R, R57K, L63Q, I64V, K70R, I85V, L89M	B
	CA6007	CA64625	FJ983194	NFV, IDV, RTV, ATV	466	M46L, I84V, L90M	L10F, L33I, N88D	I13V, Q18H, K20KR, M36MI, N37D, K55R, D60E, I62V, L63P, I66F, A71V, I72T, T91TS	B
	CA6348	CA16095	AY032307	SQV, RTV, NFV	190	N88NS, L90M	L23LI, L33I, Q58E, G73GS	I13V, E35ED, M36IL, R57K, I62V, L63P, H69Y, A71V, I72T, V75VI, V82I, I93IL	B
	CA6404	CA16167	AY032359	IDV	82	M46I, L76V	L10LF, L33I	R8R*, I13V, K14KT, I15IL, L19P, K20I, M36I, I62V, I64V	B
	CA6589	CA16528	AY032495	NFV, IDV, SQV, RTV	120	D30N, I54V, L90M	L10F, L33I, N88D	K20R, E35D, M36I, R57K, L63P, C67CY, A71AT, I93L	B
Kempf (2001)	DK-3143	DK-3143		NFV	68	D30N, L90M	L33I, N88D	I13V, L19V, E35D, M36I, P39Q, I62IV, L63P, I64V, A71T	B
	DK-4784	DK-4784		IDV, SQV, RTV	193	M46L, G48S, I54V, V82A	L10IF, L24I, L33I, F53L	K20R, E35D, M36I, N37D, R41K, K55R, R57K, L63P, I64V	B
		6329_d153		IDV, SQV, RTV, LPV	214	M46L, G48S, I54V, V82A	L24I, L33I, F53L	L10I, K20R, E35D, M36I, N37D, R41K, K55R, R57K, L63P, I64V	B
	DK-8923	DK-8923		IDV	198	I54V, V82A, L90M	L33I	T12S, L19I, M36MI, N37A, R57K, L63P, I64V, A71V, I93L	B
Kantor (2002)	CA1549	CA12713	AY047439	IDV, SQV, NFV, APV	159	M46L, I54V, V82A	L24I, L33I, K43T, G73S	L10I, I15V, K20R, M36I, Q61N, L63P, A71V	B
	CA3914	CA20474	AY047453	NFV, APV	185	M46I, L90M	L33I, T74P	L10LI, R41RK, I62V, L63P, H69HY, A71T, I72V, V77I, I93L	B
Maguire (2002)	SW31914	SW31914		APV	48	I54M	L33I	L19V, N37Q, P39S, R41K, L63P, V82I, I93L	B
Margot (2002)	MM-405036789	4050367891		PI	NA	D30N, I54V, L90M	L10F, L33I, N88D	I13V, E35D, M36I, I62IV, L63P, A71T, I72IT, I93L	B
	MM-348036654	3480366541		PI	NA		L33I	R41K, L63P, K70R, I93L	B
Romano (2002)	MZ-pt8	pt8-t0	AF493343	SQV, IDV, NFV, APV		I54V, V82A, L90M	L33I, Q58E, G73S	L10I, E35D, M36I, R41K, K55R, I62V, L63P, A71V	B
		pt8-t1	AF493384	SQV, IDV, NFV, APV, LPV		I54V, V82A, L90M	L33I, Q58E, G73S	L10I, K20R, E35D, M36I, R41K, K55R, I62V, L63P, A71V	B
	MZ-pt33	pt33-t0	AF493368	SQV, IDV, RTV		I54V, V82A, L90M	L33I, G73S	L10I, E35D, M36I, N37D, K45R, I62IV, L63P, A71V, I72IL	B
		pt33-t1	AF493407	SQV, IDV, RTV, LPV		I54V, V82A, L90M	L33I, G73S	L10I, K20KR, E34EK, E35D, M36I, N37D, K45R, I62V, L63P, A71V, I72IL	B
	MZ-pt19	pt19-t0	AF493354	SQV, NFV, IDV, RTV		M46I, I84V, L90M	L10F, L33I, G73S, N83D	A22V, E35G, M36I, R41K, I62V, L63P, A71V, I72L, I85V	B
Tural (2002)	110634	110634		IDV	80	M46I, N88S	L33I	N37S, R41K, L63P, V77I, I93L	B
	880920	880920		RTV, IDV, NFV	126	I54V, V82A	L33I	L10I, I13V, G27R, M36I, L63P, I64V	B
Gonzales (2003)	CA1251	CA11879	AY305979	SQV, RTV, IDV	164	I84V, L90M	L33I, N88D	L10I, I13V, E35D, M36I, R41K, L63P, I66IF, A71V	B
	CA1446	CA24293	AY305971	IDV, SQV, NFV, RTV	206	M46I, I54V, V82T, I84V	L24I, L33I, L89V	L10I, I13V, K20R, E35D, M36I, N37D, R57KN, L63P, A71V, I93L	B
Shafer (2003)	A384_1768	1768b	EF548788	NFV	55	L90M	L33I	L19Q, M36I, I62V, L63P, K70R, A71T, I72T	B
Wu (2003)	CA1446	CA12736	AF544479	IDV, SQV, NFV, RTV	112	M46I, I54V, V82T, I84V	L24I, L33I, L89V	L10I, I13V, E35D, M36I, N37D, R57K, L63P, A71V, I93L	B
	CA8355	CA21281	AF544615	RTV, IDV, SQV, APV	316	V32I, M46I, I47V, I54V, L90M	L23I, L33I, F53L, G73C	L10I, E35D, M36I, I62V, L63P, I64V, I66L, A71X, I72MV, I93L	B
Colonno (2004)	RC-009-012-015	012-01511		NFV		D30N	L10F, L33I, N88D	I13V, E35D, M36I, N37D, L63P, I64V, H69Y, A71V, V77I	B
	RC-009-008-089	008-08921		NFV, SQV, ATV	29	D30N, I54L, I84V	L10F, L33I, F53L, N88D	T12A, I13V, E35D, M36I, D60E, I62V, L63P, I66V, A71T, I85V, I93L	B
	RC-009-017-005	017-00511		NFV		D30N	L10F, L33I, N88D	I13V, I15R, E35D, M36I, R41K, L63P, I64V	B
		017-00521		NFV, SQV, ATV	28	D30N	L10F, L33I, N88D	I13V, K14R, E35D, M36I, R41K, I64V	B
Gomez-Carrillo (2004)	125346	125346	AY366045	PI	NA		L33I	N37S, P39Q, L63P, A71V, I93L	B
Montes (2004)	MB_patSAR	02_SAR732	AJ577994	NFV	52	D30N	L33I, N88D	L10I, I15L, Q61E, L63P	B
	MB_patGIR	02_GIR722	AJ577899	SQV, IDV, NFV, RTV	328	I84V, L90M	L33I, G73S	L10I, K20I, E35D, M36I, I62V, L63P, H69N, A71V	B
Rhee (2004)	CA14470	CA34189	AY798496	Unknown, IDV, RTV	>47	M46I, I54V, V82A	L33I, K43T, T74TP	Q7R, L10I, K20R, M36I, K55R, I62V, L63X, I64V, I85V, L89M	B
Rhee (2005)	CA1446	CA9992	AY796687	IDV, SQV, NFV, RTV	88	M46I, I54V, V82T, I84V	L24I, L33I, L89V	L10I, I13V, E35D, M36I, N37D, R57K, L63P, A71V, I85V, I93L	B
		CA38106	AY796688	IDV, SQV, NFV, RTV, LPV	304	M46I, I54V, V82T, I84V	V11VI, L24I, L33I, L89V	L10I, I13V, Q18QH, K20R, E35D, M36I, N37D, R57K, L63P, A71V, I72IV, I93L	B
	CA3894	CA23686	AY796938	PI, RTV, IDV, APV, LPV, SQV	>118	I54V, I84V, L90M	L10F, L33I, Q58QE, G73S	K20R, E35D, M36I, I62V, L63P, I66V, A71V, V82I, Q92K, I93L, C95F	B
	CA3914	CA17503	AY796945	NFV	168	M46I, L90M	L33I, T74P	R41K, I62V, L63P, H69HY, A71T, I72V, V77I, I93L	B
		CA34152	AY796946	NFV, APV, LPV	260		L33I, T74TP	L10I, R41K, I62IV, L63P, A71T, I72V, V77I, L89LM, I93L	B
	SWC-4651	P4651-319		IDV	11		L33I	N37S, I62V, L63S, I64L, A71V, V77I	B
	CA5173	CA24309	AY797255	NFV, SQV, RTV, IDV, APV	214	D30N, M46L, I54V, L90M	L33I, N88D	I13V, E35D, M36I, R57K, L63P, I93L	B
	CA5544	CA41232	AY797345	IDV	113		L33I	N37S, P39S, L63P, H69Y, A71V, V77I, I93L	B
	CA6404	CA33633	AY797394	IDV	82	M46I, L76V	L33I	I13V, L19P, K20I, M36I, I64V	B
	CA7950	CA37708	AY797610	NFV, RTV, IDV	330	D30N, I54A	L10F, V11VI, L33I, N88D	I13V, K20KR, E35D, M36I, N37C, I62V, L63P, A71T, I93L	B
	CA8049	CA48095	AY797673	IDV, NFV, SQV, RTV, ATV	284	D30N, I54V, L90M	L33I, N88D	I13V, E35D, M36I, N37T, I62V, L63P, A71T	B
	CA8355	CA33974	AY797717	RTV, IDV, SQV, APV, LPV	398	V32I, M46I, I47V, I50V, I54V, L90M	L23I, L33I, F53L, G73C	L10I, K20R, E35D, M36I, I62V, L63P, I64V, I66L, A71I, I72V, I93L	B
	CA9668	CA23620	AY797790	NFV	4		L33I	N37S, P39Q, R41K, L63P, A71V, I93L	B
		CA23622	AY797791	NFV	4		L33I	N37S, P39Q, R41K, L63P, A71V, I93L	B
		CA33965	AY797793	NFV, Unknown	>4		L33I	N37S, P39S, R41K, L63P, A71V, I93L	B
	CA14470	CA33761	AY798088	Unknown, IDV	>22	M46I, I54V, V82A	L33I, K43T	Q7R, L10I, K20KR, M36I, K55KR, D60DE, I62V, L63LV, I64V, I85V, L89M	B
Baxter (2006)	12-4072	4072-30305	DQ876125	PI	NA	I54L, I84V, L90M	L33I, G73S	L10I, I13V, E34Q, M36MIL, I62V, L63P, A71T, I72V, Q92K	B
	12-4059	4059-30716	DQ876141	PI	NA	M46MI, G48V, I50V, I54T, V82A	L33I, Q58E	L10I, I13V, K20R, E34Q, E35D, M36I, L63P, A71I, I72V, I93L	B
	12-4051	4051-30822	DQ876157	PI	NA	M46I, I54V, V82A, L90M	L10F, V11VI, L33I	T12K, I13V, L19LP, K20M, E35D, M36I, N37D, I62V, L63P, I66F, A71T, I93L, C95F	B
	12-4079	4079-30224	DQ876172	PI	NA	M46I, I84V, L90M	L33I, G73S	L10I, V11L, I13V, K14R, A22V, E35D, M36I, N37D, I62V, L63P, A71V, I72V	B
	12-1647	1647-30421	DQ876200	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	V11I, L33I, L89V	L10I, I13V, G16A, L19P, K20V, A22V, E35G, N37D, D60E, L63P, K70T, A71I, G73E, V77I, I93L	B
	12-2028	2028-30723	DQ876339	PI	NA	M46I, I54V, V82A, L90M	L24I, L33I, Q58E	L10I, I13V, K20M, E35N, M36I, R41RK, K55R, R57RK, D60E, I62IV, L63E, I64V, A71T, V75I, T91A	B
	12-2167	2167-30702	DQ876486	PI	NA	D30N, I50L	L10LF, V11VI, L33I, N88D	I13V, E35D, M36I, K45KI, R57K, L63P, A71T	B
	12-1390	1390-30813	DQ876568	PI	NA	M46I, I54M, I84V, L90M	L33I	L10I, G16E, N37Q, P39S, R41RK, L63H, A71V, I72T, V77I, I85V, I93L	B
	12-1418	1418-30820	DQ876584	PI	NA	V32I, M46I, I47V, I54IV, V82AT, L90M	V11I, L33I, K43IMT, F53L, L89V	L10V, I13V, K14T, L19T, K20T, E35D, M36I, N37D, K55R, R57K, D60N, I62V, L63P, I66IL, C67L, H69Q, A71I	B
	12-1208	1208-30507	DQ876652	PI	NA	M46L, I54V, V82A, L90M	L33I, K43T, F53L	L10I, G16E, K20R, E35D, M36I, N37NI, K55R, R57K, D60E, I62IV, L63T, I64V, A71V, I85V, Q92K, I93L	B
	12-1216	1216-30822	DQ876653	PI	NA	D30N, I54V, L90M	L10F, L33I, N88D	T12S, I13V, K20T, M36I, L63P, I64V, A71T, I72IT, V75VI, I93L	B
	12-2473	2473-30821	DQ876670	PI	NA	M46I, I84V, L90M	V11I, L33I, G73GA, L89V	L10I, I13V, K20I, M36I, I62V, L63P, G68GE, H69HR, A71T, I72IT, V82I, I93L	B
	12-1572	1572-30508	DQ876680	PI	NA	M46L, I47V, I54M, I84V, L90M	L33I	L10I, I13V, E35D, M36L, N37D, K55R, R57K, I62V, L63P, I66F, A71V	B
	12-3119	3119-30710	DQ879133	PI, RTV, TPV	>12	M46L, I54V, V82A, L90M	L33I, N88D	L10I, I15V, L19LV, K20IM, E35EG, M36I, R41K, K45KR, I62V, L63P, A71T, I72IM, I85V	B
		3119-40623	DQ879132	PI, RTV, TPV	>62	M46L, I54V, V82T, L90M	V11I, L33I, N88D	I15V, K20V, E35G, M36I, R41K, I62V, L63P, I66L, A71T, I72M, I85V, F99Y	B
	12-1399	1399-30625	DQ876767	PI	NA	G48V, I50V, I54V, V82A	L33I, K43T	L10I, T12P, I13V, K20R, E35D, M36L, Q61E, I62V, L63P, I64V, A71T, V77I	B
	12-1413	1413-30821	DQ876797	PI	NA	I54IV, I84V, L90M	L10FI, V11I, L33I, G73GS, N88ND	I13V, L19V, E35D, M36I, I62IV, L63P, A71AV	B
	12-1287	1287-30407	DQ876867	PI	NA	M46I, I54V, I84V	L24I, L33I	L10I, I13V, L19Q, K20M, M36I, D60E, L63P	B
	12-1197	1197-30303	DQ876955	PI	NA	I54V, V82A, L90M	L10F, L33I, K43T	L19I, K20R, E35D, M36I, R41K, R57RK, D60DE, I62V, L63P, I64IV, L89LM, I93L	B
	12-1958	1958-30606	DQ876990	PI	NA	I54V, L76V, V82F	L23I, L33I, Q58E	L10I, Q18E, K20KR, E34D, E35D, M36I, N37C, I62V, L63P, H69R, L89M	B
	12-2148	2148-30723	DQ877080	PI	NA	M46L, G48S, I54V, V82A	L24I, L33I, F53L	L10I, K20R, E35D, M36I, N37D, R41K, K55R, R57K, L63P, I64V	B
	12-3148	3148-30506	DQ877158	PI	NA	V32I, M46I, I54V, V82A	L33I, F53L, N83D	L10I, I13V, K14M, K20R, M36I, N37D, L63P, I64V, A71V, T91S	B
	12-3063	3063-30325	DQ877224	PI	NA	M46I, I47A, I84V, L90M	L33I, G73GS	L10I, L24F, N37D, K45R, I62V, L63P, A71V, I72L, V77I, I93L	B
	48-1001	1001-30609	DQ877310	PI	NA	M46L, I84V	L10F, L33I, L89V	I13V, M36ML, N37C, K55R, R57RK, L63P, H69Q, A71T, Q92R	B
	48-1066	1066-30617	DQ877320	PI	NA	I54V, V82A, L90M	L33I, F53L, G73GS, L89LV	L10I, I13V, K20R, E35D, M36I, R41RK, K43E, K55R, R57K, D60K, Q61N, I62V, L63P, A71I, I72E, C95L	B
	48-1201	1201-30623	DQ877745	PI	NA	M46L, I54V, V82A, L90M	L10F, L33I, K43T, N88D	T4P, K20R, E35D, M36I, N37D, I62V, L63P, C67L, A71V, I72L	B
	48-1248	1248-30623	DQ877771	PI	NA	M46I, I54V, V82T, L90M	L33I, K43T, G73S, N88G	L10I, L19LV, K20R, E35D, M36I, N37DE, K55R, I62V, L63P, A71V, I72V, V75I, I85V	B
	48-2004	2004-30424	DQ877839	PI	NA	M46I, I54T, V82A	L10F, L33I, K43T	I13V, K20T, M36I, K55R, R57K, D60E, Q61DE, L63P, I64V, A71V	B
	48-2605	2605-30317	DQ877897	PI	NA	M46L, G48V, I50V, I54T, V82A	L33I	L10IV, K20R, M36I, N37S, I62V, L63P, I64V, H69R, A71V, I85V	B
	48-2611	2611-30513	DQ877902	PI	NA	M46I, I54A, V82F, L90M	L33I	L10I, K14R, E35D, M36I, N37D, R41K, L63P, H69HY, A71V, I93L	B
	48-3005	3005-30226	DQ877915	PI	NA	M46I, I54V, I84V, L90M	L10F, V11I, L33I, G73S	A22V, E35D, M36I, I62V, L63P, A71V, I72L, N83S, I85V	B
	48-3019	3019-30812	DQ877929	PI	NA	M46L, I54V, V82A, L90M	L10F, L33I, Q58E, L89V	T4PS, V11L, I13V, L19LV, K20I, E35D, M36I, L63P, A71V, T91TCS, I93L	B
	48-3038	3038-30304	DQ877949	PI	NA	V32VI, M46MI, I47V, I54M, I84IV, L90M	L10F, L33I, K43KT, N88ND	K20I, E35D, M36I, N37D, L63P, A71T, I85V	B
	48-3106	3106-30425	DQ878012	PI	NA	M46L, I54V, V82C, L90M	L10F, L33I, Q58E	K20R, L24F, E35D, M36I, N37DE, K55R, R57K, I62IV, L63P, A71V, I93L	B
	48-3122	3122-30526	DQ878030	PI	NA	M46I, I54V, V82A, L90LM	L10F, L33I, K43T, N88D, L89V	I13V, E35D, M36I, R41K, K55R, R57RK, D60E, I62V, L63P, A71T	B
	48-3140	3140-30414	DQ878051	PI	NA	D30N, I54L, L90M	L33I, N88D	L10I, K20R, E35N, M36I, I62V, L63P, A71T, I85V, I93L	B
	48-3190	3190-30604	DQ878100	PI	NA	M46L, I54V, V82A, L90M	L33I, K43T, F53L, L89V	L10I, I13V, L19I, K20R, A22V, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71V, I72T, Q92K	B
	48-3307	3307-30826	DQ878211	PI	NA	I54V, V82A, L90M	V11I, L33I, K43T, G73S	L10I, T12P, L19P, K20M, A22V, E35D, M36I, I62V, L63P, A71V, I72L, I85V	B
	48-3308	3308-30821	DQ878212	PI	NA	M46I, I54V, V82A, L90M	L33I	L10V, I13V, L19V, K20T, E35D, M36I, R41RK, L63P, A71T, T74S, I93IL	B
	48-3320	3320-30829	DQ878219	PI	NA	M46I, I54V, L76V, V82M, L90M	L33I, Q58E	L10V, K20R, E35D, M36I, N37D, K55R, R57K, Q61QE, I62V, L63P, K70T, A71V, L89M, I93L	B
		3320-30917	DQ878220	PI, RTV, TPV	>3	M46I, I54V, L76V, V82M, L90M	L33I, Q58E	L10V, K20R, E35D, M36I, N37D, K55R, R57K, Q61QE, I62V, L63P, K70T, A71V, L89M, I93L	B
	48-4032	4032-30414	DQ878266	PI	NA	M46I, I54V, I84V, L90M	L33I	L10I, I13V, K20T, M36L, R41K, I62IV, L63P, I64V, T74E, L89LM, Q92K	B
	48-4054	4054-30430	DQ878286	PI	NA	M46I, I54V, V82S	L24I, L33I, F53FL, Q58E	L10I, I13V, L19V, K20M, E35D, M36I, N37S, R41K, K55R, I62V, L63P, I64V, A71V, T74S, I93L	B
	48-4057	4057-30310	DQ878289	PI	NA	L90LM	L33I	E35D, N37D, L63ST, A71V, I72T, I93L	B
	48-4072	4072-30218	DQ878301	PI	NA	D30N, M46I, I54L, V82F, L90M	L33I, Q58E, N88D	L10IV, I13A, K20R, A22V, E35D, M36I, N37E, R57K, D60N, Q61E, L63P, I64V, A71V, I72M, V75I, I93L	B
	48-4147	4147-30325	DQ878379	PI	NA	V32I, M46I, I47V, I50V, I54L, L90M	L33I, K43T, L89V	T12S, I13V, K20T, E35D, M36I, N37DE, L63P, A71IV, V77L, P79S, V82I, I93L	B
	48-4163	4163-30403	DQ878396	PI	NA	M46I, I54V, I84V, L90M	L33I, Q58E, T74P	L10I, V11L, I13V, Q18H, A22V, E35D, M36I, N37D, I62V, L63P, H69R, A71V, Q92K	B
	48-4231	4231-30618	DQ878463	PI	NA	M46I, I54V, V82S	L24I, L33I, F53FL, Q58E	L10I, I13V, L19V, K20M, E35D, M36I, N37S, R41K, K55R, I62V, L63P, I64V, A71V, T74S, I93L	B
	48-4261	4261-30530	DQ878493	PI	NA	M46I, L76V, I84V, L90M	L10F, V11VI, L33I, Q58E, L89V	I13V, Q18QH, K20M, M36I, I62V, L63P, A71T, P79A, T91S, Q92K	B
	48-4267	4267-40518	DQ878500	PI, RTV, TPV	>47	M46I, I54T, V82VL, I84V, L90M	L33I	L10I, I13V, K20I, E34Q, E35G, M36I, L63P, I64V, T74S	B
	48-5004	5004-30421	DQ878537	PI	NA	V32I, M46I, I47V, I54V, I84V	V11I, L33I, K43T	L10I, I13V, A22V, E35D, N37T, R41K, D60E, Q61E, I62V, L63P, I64V, V77VI	B
	48-5007	5007-30626	DQ878540	PI	NA	M46I, G48V, I54T, V82A	L33I	L10I, I13V, L19I, K20M, E35DN, M36I, N37D, I62V, L63P, I64V, T74S, N83S, T91TS	B
	48-5056	5056-30903	DQ878575	PI	NA	M46I, I54V, L76V, V82A, L90M	L33I, Q58E	L10I, I13V, L19Q, K20R, E35D, M36I, N37D, K55KR, R57K, D60EQ, Q61D, I62V, L63P, I64V, A71V, I93L	B
	48-5062	5062-30603	DQ878579	PI	NA	M46I, I54V, I84V, L90M	L33I, G73C	L10I, I13V, Q18H, K20T, E34EQ, E35D, M36I, K55R, D60E, Q61D, I62V, L63P, I64V, I66L, I72K, P79A, I93L	B
	48-5072	5072-30807	DQ878582	PI	NA	M46I, I47V, I54V, V82A, L90M	L10F, L33I, Q58E, L89V	I13V, K20M, E35N, M36I, N37D, K55R, D60E, Q61E, I62V, L63P, A71T, I72T, Q92QR	B
	48-6009	6009-30303	DQ878605	PI	NA	I54V, L76V, V82A, L90M	L10F, L33I, Q58E, G73S, L89V	I13V, L19LV, K20M, M36L, L38W, I62V, L63P, A71V	B
	48-6036	6036-30428	DQ878635	PI	NA	M46I, I54V, V82A, L90M	L33I, N88D	L10V, I13V, G16A, K20R, E35D, M36I, R57K, L63P, A71T	B
	48-6044	6044-30507	DQ878643	PI	NA	M46I, I47V, I54V, V82A, L90M	L33I, L89V	L10I, I13A, K20M, A22V, E35N, M36I, R41K, R57K, D60E, I62V, L63P, A71T, I72M, T74E, Q92K	B
	48-6047	6047-30515	DQ878646	PI	NA	M46L, I54V, V82F, L90M	L33I, Q58E, G73S, L89V	L10I, I13V, E35D, M36I, Q61QE, I62V, L63PT, C67Y, A71AT, I72IT	B
	48-6063	6063-30728	DQ878661	PI	NA	G48V, I54V, V82A	L33I, K43T	L10I, I13V, K20M, E35D, M36I, R41RK, R57K, I62V, L63LP, I64V, A71AT, T74TA, N83S, T91S	B
	48-6066	6066-30829	DQ878664	PI	NA	M46L, I54V, V82A	L10F, L33I, Q58E	I13V, K20R, M36I, N37T, R41K, I62V, L63T, I64V, T74S	B
	48-6099	6099-30618	DQ878694	PI	NA	M46L, I54L, V82A, L90M	L33I, Q58E, G73S	L10I, K20V, E35D, M36I, N37D, Q61D, I62V, L63P, I66F, C67Y, A71T, I72R	B
	48-6165	6165-30903	DQ878741	PI	NA	I54V, V82A	L10F, L24I, L33I	I13IV, K20KR, E35D, M36I, R41RK, L63P, I64V	B
	48-6166	6166-30729	DQ878742	PI	NA	I54V, I84V, L90M	V11VI, L33I, G73GS, N83D, L89V	L10I, I13V, L19LV, K20R, A22V, E35D, M36I, N37E, I62IV, L63P, A71AITV, Q92QK	B
	48-6182	6182-30721	DQ878754	PI	NA	M46I, I47V, I54L, V82A, L90M	V11I, L33I, F53L, Q58E, G73S	L10I, I13V, L19I, K20R, E34Q, E35D, M36I, R41K, K55R, R57K, I62V, L63P, A71V, I72L	B
	48-6211	6211-30821	DQ878784	PI	NA	M46L, I54IMV, I84V, L90M	V11I, L33I	L10I, I13V, A22V, E35D, M36I, N37D, D60DE, I62V, L63P, A71V, I72IT	B
	48-6219	6219-30730	DQ878786	PI	NA	M46L, I54V, V82A, L90M	L33I	K20R, E35D, M36I, L63P, A71I, I93L	B
	48-6286	6286-30820	DQ878834	PI	NA	G48V, I54S, V82A, I84V	L33I, Q58E	L10I, I13V, Q18H, K20M, M36I, I62V, L63P, I64V, T74S	B
	48-6306	6306-30918	DQ878845	PI	NA	I54V, V82A	L33I	L10V, I13V, K20I, M36I, P39S, D60E, I64V, A71V, V75I, I93L	B
	48-6315	6315-30923	DQ878852	PI	NA	M46MI, I54IV, V82VA, L90LM	L33I	D60E, L63P, I64IV, H69N, A71AV, I93L	B
	48-6318	6318-30925	DQ878855	PI	NA	M46L, I84V, L90M	L10F, L33I, Q58E	T12AE, I13V, L19P, K20I, E35D, M36I, L63P, I64V, A71V, P79R, L89I, T91S, I93L	B
	48-6319	6319-30925	DQ878856	PI	NA	G48V, I54V, V82S, L90M	L33I, Q58QE	L10I, I13V, K20M, M36I, I62IV, L63P, C67C*WY, L89I	B
	48-6329	6329-30924	DQ878862	PI	NA	I54IL, I84V	L33I, N83D	L10IV, T12IV, I13AV, A22V, E35D, M36I, Q61HN, I62V, L63Q, I64V, A71AT, I72IT, T74S, V75VI, T91TS	B
	48-6344	6344-30918	DQ878867	PI	NA	M46I, I47IV, I54IL, L76LV, I84V, L90M	L10FI, L33I, N83D, L89V	I13V, Q18H, A22V, E35N, M36I, N37D, R41RK, K55KR, I62V, L63P, A71V	B
	48-7034	7034-30812	DQ878913	PI	NA	M46I, I54V, L76V, I84V, L90M	L33I, G73S, L89V	L10I, V11L, I13V, I15V, K20I, M36I, K55KR, R57RK, I62V, L63P, A71V, I72M	B
	48-7100	7100-30721	DQ878953	PI	NA	M46MI, I50V, I54V, V82A, L90M	L10F, L33I, G73S, L89V	I13V, L19I, K20M, E35D, M36I, R41K, I62V, L63P, A71V, I72IM	B
	48-7141	7141-30731	DQ878979	PI	NA	D30N, V82A	L10F, L33I, N88D	I13V, K20T, M36I, L63P, I64V, V75I	B
	48-7148	7148-30630	DQ878986	PI	NA	I50V, I54V, L90M	L33I, G73S	I13V, E35D, M36I, I62V, L63P, H69R, A71V	B
	48-9212	9212-30929	DQ877492	PI	NA	M46I, I54V, L76V, V82F, L90M	L33I, Q58E	L10I, E35D, M36I, N37D, I62V, L63V, I64V, A71V, I93L	B
	48-9254	9254-30909	DQ877605	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	L33I, Q58E, G73S, L89V	L10I, V11VL, I13V, K20KI, E35DN, M36I, N37E, K55R, R57K, Q61QH, L63P, H69HR, A71V, I72M, V77VI, I85V	B
	48-9159	9159-30924	DQ877674	PI	NA	M46L, I54V, I84V, L90M	L33I, L89V	L10I, I15V, L19P, K20I, M36I, I62V, L63P, H69HY, A71V, T74A, I85V, I93L	B
	48-9166	9166-30925	DQ877678	PI	NA	D30N, L90LM	L10F, L33I, N88D	E35D, M36I, R41K, I62IMV, L63P, L89F, I93L	B
	48-9146	9146-30825	DQ877712	PI	NA	L90M	L33I, N88D	I15V, E35D, M36I, N37S, R41K, I62V, L63P, A71T, I85V	B
	48-9147	9147-30825	DQ877713	PI	NA	D30N, M46L, L90M	L10F, L33I, N88D	I13V, K14R, I15V, Q18QK, L19V, K20T, M36I, R41K, I62V, L63P, I64IV, K70E, A71AV, I93L	B
	48-7210	7210-30923	DQ879035	PI	NA	M46I, I54A, V82A, L90M	L33I	L10I, K20R, E35D, M36I, N37E, R57RK, I62IV, L63P, A71V, I93L	B
	48-7211	7211-30930	DQ879036	PI	NA	M46I, I54V, V82A	L24I, L33I, K43T, G73T	L10I, Q18H, K20R, E35D, M36I, L63P, I64V, A71V, I72M	B
Mitsuya (2006)	CA8049	CA59208	DQ780923	IDV, NFV, SQV, RTV, ATV	354	D30N, I54V, L90M	L33I, N88D	I13V, E35D, M36I, N37T, I62V, L63P, A71T, T74S	B
Rhee (2006)	CA14395	CA63817		Unknown, RTV, IDV	>212	M46I, I54A, V82A, L90M	L33I, L89V	L10I, I13V, L19LV, K20I, E35D, M36I, N37ND, L63P, C67L, H69K, A71IV, I72IM	B
	CA16503	CA39193		PI, Unknown	NA	M46I, V82A	L24I, L33I, Q58E	K20I, E35D, M36I, N37S, L63P, I64V, H69Q, I72IV	B
Eyer-Silva (2007)	BRSQ70	05BRSQ70	EF042668	LPV	52		L33I	N37T, K45R, L63P, I64V, I93L	B
Zolopa (2007)	7	AZ_7		RTV, ATV	24	V32I, I54V, L90M	L23LI, L33I, G73S	L10I, I15IV, K20R, E35D, M36I, N37S, R41K, Q61H, L63P, A71V, I72V, I85V	B
Riddler (2008)	RG52107	RG52107w84		LPV	84		L33I	T12A, E35D, R41K, L63P, A71T, I93L	B
Cardoso (2009)	3006	BRGO3006	FJ618910	PI	NA	D30N, I54L	L10F, L33I, N88D	T12S, K14R, L19V, K20T, E35N, M36I, N37S, R41K, L63P, A71T, I85V, I93L	B
	3039	BRGO3039	FJ638428	PI	NA	V32I, M46I, I47V, V82A, L90M	L33I, K43T	L10I, L19I, K20R, E35D, N37S, R41K, K55R, R57K, L63P, A71V, V77I, I85V, I93L	B
	3102	BRGO3102	FJ638446	PI	NA	M46MI, I54V, V82S	L10F, L24I, L33I	I13V, L19I, K20M, M36I, N37D, I62V, L63P, I64V, T74S, V75I	B
De Meyer (2009)	LPV28	LPV28BL		PI	NA	M46I, I54V, L76V, I84V	L24I, L33I, F53L	K20R, M36I, D60E, I62V, L63P, I64V, A71ITV	B
		LPV28-48w		PI, LPV	>48	M46I, I54V, L76V, I84V	L24I, L33I, F53L	K20R, M36I, D60E, I62V, L63P, I64V, A71ITV	B
	LPV55	LPV55-48w		LPV	48		L33I	I62V, L63P, A71T, V77I, I93L	B
Dumans (2009)	PA305	PA305	DQ659461	NFV	161	M46I, L76V, L90M	L10F, L33I, Q58E, L89V	I13V, Q18H, E35D, M36I, N37D, I62V, L63P, A71T, I85V, I93L	B
Dau (2010)	05601A	05601A	GU581674	PI	NA	M46I, I54V, V82A	L24I, L33I, F53L, Q58E	L10I, E35D, M36MI, N37S, I62V, L63Q, I64V, K70V, A71AV, T74K	B
	06344A	06344A	GU581736	PI	NA	M46L, I54V, V82A, L90M	L33I	L10I, I13V, K20R, E35D, M36I, N37D, D60E, I62V, L63P, A71V, I93L	B
	06415A	06415A	GU581743	PI	NA	V32I, M46I, I47V, I54V, V82A	L33I, F53L	L10I, I13V, K14MV, K20R, M36I, N37D, L63P, I64V, A71V, T91TAS	B
	06500A	06500A	GU581756	PI	NA	M46I, I54V, L76LV, V82VFI, L90M	L33I, G73C, L89V	L10I, V11L, I13V, K20V, M36I, P39T, I62V, L63P, I64V, T74S, I93IL	B
	07106A	07106A	GU581818	PI	NA	M46I, I47V, I54V, V82A, L90M	L33I, K43T, F53L, L89V	L10I, I13V, L19V, K20V, E35D, M36I, I62IV, L63P, A71T	B
	07893A	07893A	GU581880	PI	NA	I54M, L76V, I84V, L90M	L33I, G73S, L89V	L10I, V11L, I13V, Q18H, K20V, M36IL, I62V, L63P, A71IV	B
	08401A	08401A	GU581910	PI	NA	D30N, M46I	L33I, N88D	T12P, I13V, M36I, N37ND, P39Q, K55R, R57K, L63P, I64V, H69Y, A71T, I72T	B
	08699A	08699A	GU581935	PI	NA	D30N, M46MI, I54V, L90M	L10F, L33I, N88D	T12S, I13V, K20T, M36I, L63P, I64V, A71AT, I72IT, V75VI, I93L	B
	10075A	10075A	GU581993	PI	NA	D30N, I54V, L90M	L33I, N88D	L10V, I13V, K20R, E35D, M36I, L63P, A71T, T74S	B
	11484A	11484A	GU582043	PI	NA	M46L, I54V, V82A	L24I, L33I, G48E, F53L	L10I, I13V, K20T, E35D, N37D, R41K, Q61H, L63P, I64V, A71V, I72V, T74S, V77I, T91TCS, I93L	B
Hamkar (2010)	23	Ir-HIV-DR-23	GU724826	PI	NA	M46I, L76V, I84V, L90M	L10F, L33I, Q58E, L89V	I13V, K20M, M36I, I62V, L63P, A71T, P79A, Q92K	B
Knops (2010)	ID1561	ID1561-GT1	GU271166	SQV, NFV, IDV		I84V, L90M	L10F, L33I, L89V	I13V, K20T, M36I, I62V, L63P, A71T, P79A, Q92K	B
		ID1561-GT2	GU271167	SQV, NFV, IDV, APV, LPV	101	M46I, L76V, I84V, L90M	L10F, L33I, Q58E, L89V	I13V, K20M, M36I, I62V, L63P, A71T, P79A, Q92K	B
Rhee (2010)	CA1446	CA87357		IDV, SQV, NFV, RTV, LPV, APV	426	M46I, I54V, V82T, I84V	V11VI, L24I, L33I, L89V	L10I, I13V, Q18QH, K20R, E35D, M36I, N37D, R57K, L63P, A71V, I72IV, I93L	B
Jones (2012)	133405	133405	JN669522	PI	NA		L33I	I13V, K14KN, I15IV, L19V, M36I, N37D, D60E, L63P, L89M, Q92K	B
	137172	137172	JN669560	PI	NA	N88S	L10F, L33I	I13V, M36L, I62V, L63P	B
	142779	142779	JN669628	PI	NA	I54V, V82L	L10F, L24I, L33I, K43T	T12E, I13V, G16A, L19I, K20R, E35D, M36I, D60E, I62V, I64V	B
	151877	151877	JN669769	PI	NA	I54A, V82F, L90M	L33I	L10I, T12THNP, I13IV, G16E, L19IV, K20R, E34EK, E35D, M36I, D60E, I62V, L63T, A71V, I72T, I93L	B
	152142	152142	JN669774	PI	NA	M46I, I47V, I54V, I84V, L90M	V11I, L33I, G73S, L89V	L10Y, I13V, I15V, G17D, Q18H, K20V, E35N, M36I, N37E, K55R, R57RK, D60E, I62V, L63P, A71V, I72T, I85V, R87RG, I93L	B
	157470	157470	JN669886	PI	NA	M46I, I47V, I54V, I84V, L90M	V11I, L33I, G73S, L89V	L10Y, I13V, I15V, G17D, Q18H, K20V, E35N, M36I, N37E, K55R, R57K, D60E, I62V, L63P, A71V, I72T, I85V, I93L	B
	167925	167925	JN670167	PI	NA	L90M	L33I, N88D	L10I, I15V, L19I, E35D, M36I, D60E, I62IV, L63P, A71T, I85V, Q92R, I93L	B
	169707	169707	JN670206	PI	NA	L90M	L33I, G73S	L10V, I13V, N37C, K45R, I62V, L63P, A71T, I72T, I93L	B
	171622	171622	JN670262	PI	NA	L90LM	L33I	M36T, R41RK, L63P, G68D, H69K, A71V, I72IT, I93L	B
	177458	177458	JN670441	PI	NA	M46I, I54V, I84V, L90M	L10F, V11I, L33I, G73S	I13V, L19P, K20I, A22V, E35EDG, M36I, K55R, I62V, L63P, A71V, I72M	B
	185865	185865	JN670708	PI	NA		L33I	T12R, E35D, N37D, R41K, A71V, I72T, I93L	B
	186276	186276	JN670713	PI	NA	M46L, N88GS	L33I	K45R, I62V, L63P, A71T, I93L	B
	188852	188852	JN670760	PI	NA	D30N, I54V, L90M	L10F, V11VI, L33I, Q58E, N88D	T12N, I13V, L19M, K20T, E35N, M36I, N37S, P39Q, R57K, D60DN, Q61QHKN, I62IV, L63P, A71T, I72IM	B
	193164	193164	JN670884	PI	NA	D30N, I84V, L90M	L33I, Q58E, N88D	W6S, I13V, K20R, E35D, M36I, N37D, R57K, I62V, L63P, A71T, I72E	B
	197703	197703	JN671078	PI	NA	L90M	L33I, G73S	L10V, I13V, E35D, M36I, N37D, K45R, I62V, L63P, A71T, I72T, I93L	B
	201169	201169	JN671215	PI	NA		L33I	T12TA, L19T, N37AS, L63HP, I64IV, I72V, V77I, I93L	B
	203884	203884	JN671320	PI	NA	V32I, M46I, I47V, V82A, L90M	L33I, K43T, G73S	L10I, T12E, L19LI, K20I, E35Q, M36I, I62V, L63P, A71V	B
Mollan (2012)	MK237	MK237w38		RTV, ATV	38		L33I	N37E, K43KR, R57K, I62IV, L63S, A71T	B
	MK259	MK259w60		RTV, ATV	59		L33I	M36V, N37S, P39Q, R41K, D60E, L63P, C67S, A71V, I93L	B

Protease Inhibitors

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