<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation L24F
Rx >= 1 PI
IncludeMixtures No
References 14
Patients 94
Isolates 100
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Balotta (2000)CB-151CB-151AF252015SQV, RTV, IDV M46L, I84V, L90M L10I, L24F, E35D, M36I, I62V, L63P, I64V, A71V, V77I, N88NY, I93LB
Gonzales (2001)CA6437CA16211AY032390SQV, NFV164M46I, L90MG73STL10I, L24F, N37C, K45R, K55R, R57K, L63P, A71V, V77I, I93LB
Margot (2002)MM-3571368123571368121 PINAM46I, I84V, L90M L24F, M36I, N37D, I62V, L63P, A71V, I72V, T80TA, I93LB
Romano (2002)MZ-pt41pt41-t1AF493415IDV, RTV, LPV M46I, I54V, V82A, L90MG73SL10I, I15V, L19V, K20I, L24F, M36I, L63P, H69K, A71V, I93LB
Wu (2003)CA4914CA12111AF544578NFV, SQV, RTV, IDV68M46I, I54V, V82T, L90M L10I, L24F, N37D, L63P, A71V, V77I, I93LB
Colonno (2004)RC-009-007-064007-06421 NFV, SQV, ATV60M46I, I84V, L90ML23I, F53L, G73TL10X, I13V, K14R, I15V, G16A, L24F, E35D, N37X, I62V, L63P, I64V, I72X, V77I, I93L, C95FB
Gomez-Carrillo (2004)103277103277AY365674PINAM46I, I54V, V82A, L90ML33F, F53FL, G73SL10V, G16A, L24F, E34EQ, K45KR, K55H, Q61E, L63P, A71V, I72K, I93LB
 121150121150AY365998PINAI54V, L90ML33F, F53L, G73SI13V, L24F, L63P, A71V, V77IB
Rhee (2005)CA799CA21348AY796485RTV, IDV, SQV, NFV, Unknown, LPV, APV>210I54V, V82A, L90ML33F, G73S, L89LVL10I, I15V, K20V, L24F, E35DN, M36I, R57K, I62V, L63P, A71V, I72MB
 CA1502CA37835AY796742RTV, NFV, Unknown>222M46L, I54V, V82A, L90M L10I, I15V, L19I, K20R, L24F, M36I, R41K, L63P, A71V, I93LB
 CA5126CA23963AY797239IDV, APV242M46L, L90ML33F, G73S, L89VL10I, I13V, L24F, I62V, L63P, V77I, V82I, I93LB
 CA6437CA24640AY797405SQV, NFV, RTV, IDV230M46I, L90MG73TL10I, L24F, N37C, K45R, K55R, R57K, L63P, A71V, I72IT, V77I, I93LB
  CA37913AY797406SQV, NFV, RTV, IDV290M46I, L90MG73TL10I, L24F, N37C, K45R, K55R, R57K, L63P, A71V, I72T, V77I, I93LB
 CA8097CA20645AY797700RTV, NFV185M46L, I54V, V82A, L90ML33FI13V, L24F, I62IV, L63P, A71V, V77I, I93LB
  CA42697AY797701RTV, NFV343M46L, I54V, V82A, L90ML33F, K43KTI13V, L24F, I62IV, L63P, A71IV, V77I, I93LB
 CA14690CA34128AY798151Unknown, SQV, RTV>32M46I, I84V, L90M L10I, L19V, L24F, F53Y, L63P, A71V, I72V, V77I, Q92R, I93LB
Baxter (2006)12-16961696-30429DQ875996PINAM46I, I54V, V82A, L90ML33F, F53LL10I, L24F, E35ED, N37E, I62V, L63P, A71I, I93LB
 12-11201120-30319DQ876011PINAM46I, L90MG73CL10I, K14KR, K20I, L24F, I62V, L63P, A71V, I72V, T74S, V77I, I93LB
 12-12491249-30304DQ876080PINAM46L, I54L, V82A, L90ML10F, L33F, K43TI13V, L24F, K55R, I62V, L63P, A71V, V77I, L89I, I93LB
 12-40504050-30820DQ876156PINAI54V, I84V, L90ML10F, G73SI15V, L19P, K20V, L24F, E34Q, M36I, N37D, I62V, L63P, A71V, I72L, P79D, I93LB
 12-16461646-30403DQ876199PINAM46I, I54V, V82A, L90ML33F, G73TL10I, I13V, L19LV, K20R, L24F, E35D, M36I, K55N, I62V, L63P, A71V, I72K, V77I, I93LB
 12-10531053-30402DQ876310PINAM46L, I54V, I84V, L90ML33F, G73TL10I, K20R, L24F, E35D, M36I, N37D, K43Q, I62V, L63P, I64V, A71V, I72R, P79AB
 12-10781078-30409DQ876401PINAV32I, M46L, I54V, V82A, L90ML33F, T74PL10I, I13V, G16A, K20R, L24F, M36I, K55R, I62V, L63P, I66V, G73V, I85LB
 12-16281628-30416DQ876523PINAM46L, I54V, V82A, L90ML33F, F53LL10V, G16A, L24F, R41K, L63P, I64L, A71V, I72V, V77I, T91S, I93LB
 12-24942494-30821DQ876595PINAM46L, I54V, V82A, L90MV11VI, L33F, F53L, G73TL10I, I13V, G16A, K20R, L24F, M36MIL, R41K, K55R, I62V, L63P, A71V, I72TB
 12-14691469-30422DQ876874PINAI54IV, V82A, L90MV11IL, L33F, F53LL10I, I15V, K20V, L24F, E35N, M36I, R41K, K45KR, K55KR, D60E, I62V, L63P, A71I, I85IV, L89LIMB
 12-19491949-30528DQ876913PINAM46I, V82T, I84V, L90ML10F, L33F, G73SI13V, L24F, I62V, L63P, A71V, I72VB
 12-30963096-30513DQ877196PINAI54V, V82C, L90ML10F, G73SI13M, I15V, G17E, K20V, L24F, M36I, N37D, K43KR, R57K, D60E, I62V, L63P, A71V, I72RB
 12-30633063-30325DQ877224PINAM46I, I47A, I84V, L90ML33I, G73GSL10I, L24F, N37D, K45R, I62V, L63P, A71V, I72L, V77I, I93LB
 12-32133213-30818DQ877252PINAM46I, I54V, I84V, L90ML33F, G73TL10IT, G16A, L24F, Q61H, I62V, L63P, I66IV, A71V, I72IL, V77I, I93LB
 48-10111011-30610DQ877314PINAM46L, I54L, V82A, L90ML33F, Q58EL10I, I13IV, K20R, L24F, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93LB
 48-10641064-30611DQ877315PINAM46IL, I54V, V82A, L90MV11VI, L33F, K43T, G73SL10I, I13V, L24F, E34Q, K55R, D60E, I62V, L63P, A71V, I72K, V77I, I93LB
 48-12561256-30515DQ877782PINAM46L, I54V, V82A, L90ML10F, L33F, K43T, F53LT4P, I13V, I15V, L19LI, K20R, L24F, E35D, M36I, R41K, L63P, A71I, Q92K, I93LB
 48-14351435-30318DQ877824PINAM46L, I54V, V82A, L90MG73SL10I, I15V, G16A, L19I, K20R, L24F, E35ED, M36I, R41K, I62V, L63P, A71V, I93LB
 48-26222622-30908DQ877910PINAV32I, M46I, I47V, I54M, V82A, L90MV11I, L33F, G73S, L89VL10V, I13V, L24F, N37D, K45R, L63P, A71I, V77I, I93LB
 48-31063106-30425DQ878012PINAM46L, I54V, V82C, L90ML10F, L33I, Q58EK20R, L24F, E35D, M36I, N37DE, K55R, R57K, I62IV, L63P, A71V, I93LB
 48-31843184-30429DQ878092PINAM46L, I54V, V82A, L90ML33F, Q58E, G73STL10I, I13V, K20R, L24F, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, A71V, I72ITB
 48-32053205-30612DQ878115PINAM46L, I54V, V82A, L90MQ58EL10I, L19Q, K20R, L24F, E35D, M36I, R41K, R57RK, D60X, I62V, L63P, A71V, I93LB
 48-32373237-30521DQ878144PINAM46I, I54L, V82A, L90ML33F, G73TL10I, I13V, L24F, R41K, K55R, I62V, L63P, A71I, I72V, V77I, I93LB
 48-32783278-30910DQ878185PINAM46I, I54V, V82A, L90ML33F, F53L, G73SL10I, I13V, G16A, L24F, N37D, Q61H, L63P, I64IM, A71V, I72L, I93LB
 48-40024002-30311DQ878235PINAM46L, I54V, V82A, L90ML33F, G73SL10I, I13V, L24F, I62V, L63P, A71V, I72T, V77IB
 48-41204120-30403DQ878351PINAM46L, I54V, V82A, L90ML33F, K43T, F53L, T74PL10I, I13V, L24F, I62V, L63P, A71V, V77I, I93LB
 48-41324132-30320DQ878363PINAM46I, I54V, V82A, L90ML33F, G73SL10I, I13V, K14KR, L19I, K20R, L24F, E35D, M36I, N37D, I62V, L63P, A71V, I93LB
 48-41744174-30502DQ878408PINAM46L, I54V, V82A, L90ML33F, G73SL10I, I13V, L24F, I62V, L63P, A71V, I72T, V77IB
 48-41974197-30522DQ878430PINAM46L, I54V, V82A, L90ML33F, Q58E, G73SL10I, I13V, G16A, L24F, K55R, I62V, L63P, A71V, I72MB
 48-42004200-30515DQ878432PINAM46L, I54L, V82A, L90ML10F, L33F, K43T, F53L, G73AG16A, L19I, L24F, E34Q, K55R, D60E, I62V, L63P, I64M, A71I, I72L, I93LB
 48-42144214-30507DQ878447PINAM46L, I54V, V82A, L90ML23I, L33F, Q58E, G73GS, T74TPL10I, I13V, L24F, I62V, L63P, A71V, I93LB
 48-50135013-30513DQ878548PINAM46I, I54V, V82A, L90MQ58E, G73SL10I, I15V, G16A, L19P, K20M, L24F, M36V, K55KR, R57K, D60E, I62V, L63P, A71V, I72LB
 48-60076007-30226DQ878603PINAM46L, I54V, V82A, I84V, L90ML33F, K43TL10I, I13V, I15V, K20R, L24F, E35D, M36I, N37D, R57K, Q61N, I62V, L63A, A71V, Q92KB
 48-60246024-30407DQ878623PINAM46L, I54V, V82A, L90ML33F, Q58E, G73GSL10V, T12I, I13V, L24F, N37D, K55R, D60E, L63P, A71V, V77I, I93LB
 48-72027202-30808DQ879027PINAI54V, V82A, L90MV11VI, F53LL10I, I15V, K20I, L24F, E35D, M36I, R41K, D60E, I62V, L63P, A71I, I72LB
 48-93109310-30923DQ877295PINAM46I, L90ML33F, Q58QE, G73SL24F, N37D, L63P, A71V, I72R, V77I, I93LB
 48-90389038-30901DQ877505PINAM46L, I54V, V82A, L90ML33F, G73SL10I, G16A, L24F, K55R, R57K, D60E, I62V, L63P, A71V, I72LB
 48-91999199-30910DQ877575PINAM46L, I54V, V82A, L90MG73SL10I, I15V, G16A, K20M, L24F, E35D, M36I, R41K, K55R, I62V, L63P, A71V, I72LB
 48-90169016-30908DQ877628PINAI54V, V82A, L90ML33F, K43KPQT, G73TL10I, I13V, G16A, L24F, E34Q, R57K, Q61E, I62V, L63P, A71T, I72T, I93LB
 48-90919091-30827DQ877652PINAM46L, I54V, V82A, L90MV11I, L33F, Q58E, G73S, L89VL10I, I13V, L24F, N37D, K55R, D60DN, I62V, L63P, K70KN, A71I, I72M, V77I, C95LB
 48-91029102-30908DQ877691PINAM46I, I54V, I84V, L90MG73SL10I, Q18H, L19P, K20I, L24F, L33V, M36I, N37S, I62V, L63P, H69L, A71T, I72R, I93MB
 48-91229122-30930DQ877710PINAI54V, V82A, L90ML33F, K43KT, F53L, G73SL10I, I13V, I15V, K20R, L24F, E35D, M36I, K55R, I62V, L63P, A71V, I72VB
 48-80068006-30527DQ879051PINAM46L, V82A, L90ML10F, Q58E, G73S, L89VI15V, Q18H, K20I, L24F, R41K, L63P, A71V, I72ILM, I93LB
Rosen-Zvi (2008)7703p77-2 SQV, IDV, NFV, RTV, APV, LPV252M46I, I84V, L90ML33F, G73SL5F, L10I, L24F, E34Q, R41K, F53Y, I62V, L63P, A71V, I72K, V77I, I93LB
  05p77-3 SQV, IDV, NFV, RTV, APV, LPV368M46I, I54IL, I84V, L90ML10F, L33F, G73SL5F, I13IM, G16A, L24F, E34Q, R41K, F53Y, I62V, L63P, I64IM, A71L, I72K, V77I, I93LB
  06p77-4 SQV, IDV, NFV, RTV, APV, LPV429M46I, I54L, I84V, L90ML10F, L33F, G73SL5F, I13V, G16A, L24F, E34Q, R41K, F53Y, I62IV, L63P, I64IM, A71L, I72K, I93LB
  07p77-5 SQV, IDV, NFV, RTV, APV, LPV475M46I, I54L, I84V, L90ML10F, L33F, G73SL5F, I13V, G16A, L24F, E34Q, R41K, F53Y, I62IV, L63P, I64IM, A71L, I72K, I93LB
Dau (2010)09214A09214AGU581958PINAM46L, I54V, V82A, I84V, L90ML33F, Q58E, G73SP9PL, L10I, I13V, K20R, L24F, T31TI, E35DN, M36I, N37EQ, K55R, R57K, D60E, I62V, L63P, A71V, I72TB
 10017A10017AGU581991PINAM46I, I54L, V82A, L90ML33F, K43T, G73ST4S, L10V, I13IV, I15V, G16A, L24F, I62V, L63P, A71I, I72R, V77VI, I93LB
Jones (2012)129273129273JN669462PINAM46I, I54V, I84V, L90ML10F, G73TI13V, I15V, Q18H, K20V, L24F, L33LM, M36L, N37P, Q61H, I62V, L63P, I66V, A71T, I72T, V77I, I93LB
 140263140263JN669586PINAM46I, I54V, I84V, L90ML33LI, G73TL10I, T12TP, G16GA, L24F, E35D, M36ML, N37D, K55KR, I62V, L63P, H69HR, A71IT, I72K, V77I, I93LB
 172184172184JN670281PINAM46I, I54V, V82A, L90ML33F, G73STL10I, I13V, L24F, E35ED, M36MV, N37NT, R41K, K55R, R57RK, I62V, L63P, A71V, I93LB
 178086178086JN670469PINAM46L, I54V, V82A, L90ML33F, K43T, G73SL10I, I13V, I15IV, L19LS, K20R, L24F, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, L63P, I66V, K70KT, A71V, I72IT, I85L, I93LB
 196990196990JN671051PINAM46I, I54V, V82A, L90ML33F, G73SL10I, I15V, K20R, L24F, E35D, M36L, N37D, K55R, R57K, I62V, L63P, H69K, A71V, I72FL, V77IB
Diaz (2015)RenG16468RenG16468KT747496PINAM46I, I54V, V82A, L90ML33F, Q58E, G73SL10I, I13V, Q18IV, L24F, R41K, K55R, R57K, D60E, I62V, L63P, A71V, I72RB
 RenG15997RenG15997KT747025PINAM46I, I54V, V82A, L90ML10F, L33F, G73TT12K, I13V, L19I, L24F, E34K, K43KQ, I62V, L63P, H69Q, A71V, V77VI, I93MB
 RenG16918RenG16918KT747946PINAM46I, I54V, V82A, L90MV11I, G73S, L89VL10I, T12Q, I15V, L19T, K20I, L24F, E35D, M36I, N37E, K55R, R57K, I62V, L63P, A71V, I93LB
 RenG15958RenG15958KT746986PINAM46I, I54V, V82A, L90MQ58E, G73SL10I, I15V, K20R, L24F, E35D, M36I, N37E, K55R, R57K, D60E, I62V, L63P, A71V, I72LB
 RenG16335RenG16335KT747363PINAM46I, I54L, V82A, L90ML33F, G73TL10I, I13V, K20R, L24F, E35D, M36I, R41K, K45R, K55R, R57K, L63P, A71V, I72L, I93LB
 RenG16779RenG16779KT747807PINAM46I, I54V, V82A, L90MV11I, L33F, Q58E, G73SL10I, I13V, G16A, L24F, E34Q, N37D, K55R, I62V, L63P, A71V, I72R, V77I, I93LB
 RenG16501RenG16501KT747529PINAM46I, I54V, V82A, L90ML33F, T74PL10IV, I13V, L24F, N37D, K55KR, I62V, L63P, A71V, V77I, L89M, I93LB
 RenG17111RenG17111KT748139PINAV32I, M46I, I47V, I54M, V82A, L90ML33F, Q58E, G73SL10LI, I13V, G16A, L19Q, L24F, K55R, L63P, A71V, I72V, V77IB
 RenG16970RenG16970KT747998PINAM46L, I54V, V82S, L90ML33F, K43TL10R, I13V, G16A, L24F, K55R, R57K, D60E, Q61D, L63P, A71I, I72R, V77VI, I93LB
 RenG15232RenG15232KT746260PINAM46MI, I54V, V82A, L90MK43T, G73SL10I, T12N, I15V, L19V, K20V, L24F, E35N, M36I, D60E, I62V, L63P, A71V, I72LB
 RenG14885RenG14885KT745913PINAI54V, V82A, L90ML33IL10I, L24F, E35D, M36I, R41K, D60E, I62V, L63P, A71V, I93LB
 RenG14099RenG14099KT745127PINAM46L, I54V, V82A, L90ML33F, T74PL10IV, I13V, K20R, L24F, E35D, M36I, N37E, K55R, R57K, I62V, L63P, A71V, I93LB
 RenG14035RenG14035KT745063PINAM46I, I54V, V82A, L90MG73SL10I, I15V, G16GA, L24F, Q61H, I62V, L63P, H69K, A71V, I72LB
 RenG15294RenG15294KT746322PINAM46L, I54V, V82A, L90ML33F, F53L, Q58E, G73SQ7H, L10V, I13V, G16A, L19I, L24F, E34Q, N37Y, K55R, R57K, L63P, A71V, I72LB
 RenG14638RenG14638KT745666PINAM46I, I54V, V82A, L90MF53FL, G73GSW6L, L10V, T12TM, I13M, I15V, K20I, L24F, E34Q, K55R, L63P, H69K, A71V, T74S, V77I, I93LB
 RenG14083RenG14083KT745111PINAM46I, G48GV, I54V, V82A, L90MF53L, G73GS, L89LVL10I, T12P, I13V, K14R, G16E, K20I, L24F, L33L_L, E35G, M36I, P39S, K55R, I62V, L63H, K70E, A71I, I72V, T91TA, I93LB
 RenG14625RenG14625KT745653PINAM46L, I54V, V82A, L90ML10F, L33F, G73TI13V, L24F, R41K, L63P, H69R, A71I, I85L, I93LB
 RenG14795RenG14795KT745823PINAM46L, I54V, V82A, L90MF53L, Q58E, G73SL10I, T12I, I15V, Q18E, L24F, L33M, E34Q, M36L, L38W, K55R, R57K, D60E, Q61N, I62V, L63P, A71V, I72TB
 RenG14955RenG14955KT745983PINAI54V, V82A, L90LML10LFI15V, G16E, L19P, K20I, L24F, E34EQ, E35D, M36I, R41K, Q61QHKN, I62IV, L63A, H69HR, A71I, T74S, T91TA, I93LB
 RenG14498RenG14498KT745526PINAV32I, I47V, I54V, V82A, L90ML33F, K43T, F53L, G73S, L89VL10IV, I13V, I15V, K20R, L24F, M36L, N37D, K55R, R57RK, L63P, A71VB
 RenG14823RenG14823KT745851PINAM46I, I54V, V82A, L90MG73ST4TS, L10I, I13M, I15V, L19V, K20I, L24F, M36I, K45R, I62V, L63P, H69HQ, A71V, Q92K, I93LB
 RenG14324RenG14324KT745352PINAM46I, I54V, V82A, L90MF53FL, G73SL10IV, T12HN, I15V, L19P, K20M, L24F, E34EQ, E35G, M36I, N37E, K45R, K55KR, I62V, L63P, A71V, I93LB
 RenG12757RenG12757KT743785PINAM46ML, I54V, V82A, L90ML33F, G73SL10IV, I13V, K20R, L24F, E35D, M36I, K43Q, K45R, K55R, R57K, Q61N, I62V, L63P, A71I, I85L, I93LB
 RenG12438RenG12438KT743466PINAI54V, N88S, L90ML33F, M46V, F53LL10V, I13V, L24F, L63P, H69Y, A71V, V77I, L89T, I93LB
 RenG13240RenG13240KT744268PINAM46L, I54V, V82A, L90MQ58E, G73SL10I, I15V, G16A, L19P, K20I, L24F, E35N, M36I, K55R, R57K, I62V, L63P, A71V, I72LB
 RenG13200RenG13200KT744228PINAV32I, I47V, I54V, V82VA, L90ML33F, K43T, F53L, Q58QE, G73SL10V, I15V, K20R, L24F, E34N, E35D, M36I, N37D, D60E, L63P, A71T, V77IB
 RenG10771RenG10771KT741799PINAM46I, I54V, V82A, L90MV11VI, G73SL10I, I15V, G16A, L19E, K20I, L24F, E35N, M36I, K55KR, R57RK, I62V, L63P, A71I, I72T, I93LB
 RenG11734RenG11734KT742762PINAM46MIL, I54V, V82A, L90MF53L, L89LVL10I, I13IMV, I15V, K20I, L24F, L33L_L, M36I, K55R, R57RK, D60E, I62V, L63P, A71I, I93LB
 RenG10672RenG10672KT741700PINAM46I, I54S, V82M, L90ML33F, K43TT4TA, L10IV, T12R, G16A, L19V, L24F, E34Q, F53Y, D60E, I62V, L63P, A71L, I72V, V77I, I93LB
Abdellaziz (2016)1430214302KT339045PINAM46L, I54V, L90ML10F, K43T, V82ET12N, L19IT, K20I, L24F, E34K, E35D, M36I, N37S, K55R, R57K, I62V, L63A, I64V, A71V, I93LB