Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	L24F
Rx	>= 1 PI
IncludeMixtures	No

References	12
Patients	64
Isolates	70

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Balotta (2000)	CB-151	CB-151	AF252015	SQV, RTV, IDV		M46L, I84V, L90M		L10I, L24F, E35D, M36I, I62V, L63P, I64V, A71V, V77I, N88NY, I93L	B
Gonzales (2001)	CA6437	CA16211	AY032390	SQV, NFV	164	M46I, L90M	G73ST	L10I, L24F, N37C, K45R, K55R, R57K, L63P, A71V, V77I, I93L	B
Margot (2002)	MM-357136812	3571368121		PI	NA	M46I, I84V, L90M		L24F, M36I, N37D, I62V, L63P, A71V, I72V, T80TA, I93L	B
Romano (2002)	MZ-pt41	pt41-t1	AF493415	IDV, RTV, LPV		M46I, I54V, V82A, L90M	G73S	L10I, I15V, L19V, K20I, L24F, M36I, L63P, H69K, A71V, I93L	B
Wu (2003)	CA4914	CA12111	AF544578	NFV, SQV, RTV, IDV	68	M46I, I54V, V82T, L90M		L10I, L24F, N37D, L63P, A71V, V77I, I93L	B
Colonno (2004)	RC-009-007-064	007-06421		NFV, SQV, ATV	60	M46I, I84V, L90M	L23I, F53L, G73T	L10X, I13V, K14R, I15V, G16A, L24F, E35D, N37X, I62V, L63P, I64V, I72X, V77I, I93L, C95F	B
Gomez-Carrillo (2004)	103277	103277	AY365674	PI	NA	M46I, I54V, V82A, L90M	L33F, F53FL, G73S	L10V, G16A, L24F, E34EQ, K45KR, K55H, Q61E, L63P, A71V, I72K, I93L	B
	121150	121150	AY365998	PI	NA	I54V, L90M	L33F, F53L, G73S	I13V, L24F, L63P, A71V, V77I	B
Rhee (2005)	CA799	CA21348	AY796485	RTV, IDV, SQV, NFV, Unknown, LPV, APV	>210	I54V, V82A, L90M	L33F, G73S, L89LV	L10I, I15V, K20V, L24F, E35DN, M36I, R57K, I62V, L63P, A71V, I72M	B
	CA1502	CA37835	AY796742	RTV, NFV, Unknown	>222	M46L, I54V, V82A, L90M		L10I, I15V, L19I, K20R, L24F, M36I, R41K, L63P, A71V, I93L	B
	CA5126	CA23963	AY797239	IDV, APV	242	M46L, L90M	L33F, G73S, L89V	L10I, I13V, L24F, I62V, L63P, V77I, V82I, I93L	B
	CA6437	CA24640	AY797405	SQV, NFV, RTV, IDV	230	M46I, L90M	G73T	L10I, L24F, N37C, K45R, K55R, R57K, L63P, A71V, I72IT, V77I, I93L	B
		CA37913	AY797406	SQV, NFV, RTV, IDV	290	M46I, L90M	G73T	L10I, L24F, N37C, K45R, K55R, R57K, L63P, A71V, I72T, V77I, I93L	B
	CA8097	CA20645	AY797700	RTV, NFV	185	M46L, I54V, V82A, L90M	L33F	I13V, L24F, I62IV, L63P, A71V, V77I, I93L	B
		CA42697	AY797701	RTV, NFV	343	M46L, I54V, V82A, L90M	L33F, K43KT	I13V, L24F, I62IV, L63P, A71IV, V77I, I93L	B
	CA14690	CA34128	AY798151	Unknown, SQV, RTV	>32	M46I, I84V, L90M		L10I, L19V, L24F, F53Y, L63P, A71V, I72V, V77I, Q92R, I93L	B
Baxter (2006)	12-1696	1696-30429	DQ875996	PI	NA	M46I, I54V, V82A, L90M	L33F, F53L	L10I, L24F, E35ED, N37E, I62V, L63P, A71I, I93L	B
	12-1120	1120-30319	DQ876011	PI	NA	M46I, L90M	G73C	L10I, K14KR, K20I, L24F, I62V, L63P, A71V, I72V, T74S, V77I, I93L	B
	12-1249	1249-30304	DQ876080	PI	NA	M46L, I54L, V82A, L90M	L10F, L33F, K43T	I13V, L24F, K55R, I62V, L63P, A71V, V77I, L89I, I93L	B
	12-4050	4050-30820	DQ876156	PI	NA	I54V, I84V, L90M	L10F, G73S	I15V, L19P, K20V, L24F, E34Q, M36I, N37D, I62V, L63P, A71V, I72L, P79D, I93L	B
	12-1646	1646-30403	DQ876199	PI	NA	M46I, I54V, V82A, L90M	L33F, G73T	L10I, I13V, L19LV, K20R, L24F, E35D, M36I, K55N, I62V, L63P, A71V, I72K, V77I, I93L	B
	12-1053	1053-30402	DQ876310	PI	NA	M46L, I54V, I84V, L90M	L33F, G73T	L10I, K20R, L24F, E35D, M36I, N37D, K43Q, I62V, L63P, I64V, A71V, I72R, P79A	B
	12-1078	1078-30409	DQ876401	PI	NA	V32I, M46L, I54V, V82A, L90M	L33F, T74P	L10I, I13V, G16A, K20R, L24F, M36I, K55R, I62V, L63P, I66V, G73V, I85L	B
	12-1628	1628-30416	DQ876523	PI	NA	M46L, I54V, V82A, L90M	L33F, F53L	L10V, G16A, L24F, R41K, L63P, I64L, A71V, I72V, V77I, T91S, I93L	B
	12-2494	2494-30821	DQ876595	PI	NA	M46L, I54V, V82A, L90M	V11VI, L33F, F53L, G73T	L10I, I13V, G16A, K20R, L24F, M36MIL, R41K, K55R, I62V, L63P, A71V, I72T	B
	12-1469	1469-30422	DQ876874	PI	NA	I54IV, V82A, L90M	V11IL, L33F, F53L	L10I, I15V, K20V, L24F, E35N, M36I, R41K, K45KR, K55KR, D60E, I62V, L63P, A71I, I85IV, L89LIM	B
	12-1949	1949-30528	DQ876913	PI	NA	M46I, V82T, I84V, L90M	L10F, L33F, G73S	I13V, L24F, I62V, L63P, A71V, I72V	B
	12-3096	3096-30513	DQ877196	PI	NA	I54V, V82C, L90M	L10F, G73S	I13M, I15V, G17E, K20V, L24F, M36I, N37D, K43KR, R57K, D60E, I62V, L63P, A71V, I72R	B
	12-3063	3063-30325	DQ877224	PI	NA	M46I, I47A, I84V, L90M	L33I, G73GS	L10I, L24F, N37D, K45R, I62V, L63P, A71V, I72L, V77I, I93L	B
	12-3213	3213-30818	DQ877252	PI	NA	M46I, I54V, I84V, L90M	L33F, G73T	L10IT, G16A, L24F, Q61H, I62V, L63P, I66IV, A71V, I72IL, V77I, I93L	B
	48-1011	1011-30610	DQ877314	PI	NA	M46L, I54L, V82A, L90M	L33F, Q58E	L10I, I13IV, K20R, L24F, E35D, M36I, N37D, R41K, D60E, I62V, L63P, A71V, I93L	B
	48-1064	1064-30611	DQ877315	PI	NA	M46IL, I54V, V82A, L90M	V11VI, L33F, K43T, G73S	L10I, I13V, L24F, E34Q, K55R, D60E, I62V, L63P, A71V, I72K, V77I, I93L	B
	48-1256	1256-30515	DQ877782	PI	NA	M46L, I54V, V82A, L90M	L10F, L33F, K43T, F53L	T4P, I13V, I15V, L19LI, K20R, L24F, E35D, M36I, R41K, L63P, A71I, Q92K, I93L	B
	48-1435	1435-30318	DQ877824	PI	NA	M46L, I54V, V82A, L90M	G73S	L10I, I15V, G16A, L19I, K20R, L24F, E35ED, M36I, R41K, I62V, L63P, A71V, I93L	B
	48-2622	2622-30908	DQ877910	PI	NA	V32I, M46I, I47V, I54M, V82A, L90M	V11I, L33F, G73S, L89V	L10V, I13V, L24F, N37D, K45R, L63P, A71I, V77I, I93L	B
	48-3106	3106-30425	DQ878012	PI	NA	M46L, I54V, V82C, L90M	L10F, L33I, Q58E	K20R, L24F, E35D, M36I, N37DE, K55R, R57K, I62IV, L63P, A71V, I93L	B
	48-3184	3184-30429	DQ878092	PI	NA	M46L, I54V, V82A, L90M	L33F, Q58E, G73ST	L10I, I13V, K20R, L24F, E35D, M36I, N37D, K55R, R57RK, I62V, L63P, A71V, I72IT	B
	48-3205	3205-30612	DQ878115	PI	NA	M46L, I54V, V82A, L90M	Q58E	L10I, L19Q, K20R, L24F, E35D, M36I, R41K, R57RK, D60X, I62V, L63P, A71V, I93L	B
	48-3237	3237-30521	DQ878144	PI	NA	M46I, I54L, V82A, L90M	L33F, G73T	L10I, I13V, L24F, R41K, K55R, I62V, L63P, A71I, I72V, V77I, I93L	B
	48-3278	3278-30910	DQ878185	PI	NA	M46I, I54V, V82A, L90M	L33F, F53L, G73S	L10I, I13V, G16A, L24F, N37D, Q61H, L63P, I64IM, A71V, I72L, I93L	B
	48-4002	4002-30311	DQ878235	PI	NA	M46L, I54V, V82A, L90M	L33F, G73S	L10I, I13V, L24F, I62V, L63P, A71V, I72T, V77I	B
	48-4120	4120-30403	DQ878351	PI	NA	M46L, I54V, V82A, L90M	L33F, K43T, F53L, T74P	L10I, I13V, L24F, I62V, L63P, A71V, V77I, I93L	B
	48-4132	4132-30320	DQ878363	PI	NA	M46I, I54V, V82A, L90M	L33F, G73S	L10I, I13V, K14KR, L19I, K20R, L24F, E35D, M36I, N37D, I62V, L63P, A71V, I93L	B
	48-4174	4174-30502	DQ878408	PI	NA	M46L, I54V, V82A, L90M	L33F, G73S	L10I, I13V, L24F, I62V, L63P, A71V, I72T, V77I	B
	48-4197	4197-30522	DQ878430	PI	NA	M46L, I54V, V82A, L90M	L33F, Q58E, G73S	L10I, I13V, G16A, L24F, K55R, I62V, L63P, A71V, I72M	B
	48-4200	4200-30515	DQ878432	PI	NA	M46L, I54L, V82A, L90M	L10F, L33F, K43T, F53L, G73A	G16A, L19I, L24F, E34Q, K55R, D60E, I62V, L63P, I64M, A71I, I72L, I93L	B
	48-4214	4214-30507	DQ878447	PI	NA	M46L, I54V, V82A, L90M	L23I, L33F, Q58E, G73GS, T74TP	L10I, I13V, L24F, I62V, L63P, A71V, I93L	B
	48-5013	5013-30513	DQ878548	PI	NA	M46I, I54V, V82A, L90M	Q58E, G73S	L10I, I15V, G16A, L19P, K20M, L24F, M36V, K55KR, R57K, D60E, I62V, L63P, A71V, I72L	B
	48-6007	6007-30226	DQ878603	PI	NA	M46L, I54V, V82A, I84V, L90M	L33F, K43T	L10I, I13V, I15V, K20R, L24F, E35D, M36I, N37D, R57K, Q61N, I62V, L63A, A71V, Q92K	B
	48-6024	6024-30407	DQ878623	PI	NA	M46L, I54V, V82A, L90M	L33F, Q58E, G73GS	L10V, T12I, I13V, L24F, N37D, K55R, D60E, L63P, A71V, V77I, I93L	B
	48-7202	7202-30808	DQ879027	PI	NA	I54V, V82A, L90M	V11VI, F53L	L10I, I15V, K20I, L24F, E35D, M36I, R41K, D60E, I62V, L63P, A71I, I72L	B
	48-9310	9310-30923	DQ877295	PI	NA	M46I, L90M	L33F, Q58QE, G73S	L24F, N37D, L63P, A71V, I72R, V77I, I93L	B
	48-9038	9038-30901	DQ877505	PI	NA	M46L, I54V, V82A, L90M	L33F, G73S	L10I, G16A, L24F, K55R, R57K, D60E, I62V, L63P, A71V, I72L	B
	48-9199	9199-30910	DQ877575	PI	NA	M46L, I54V, V82A, L90M	G73S	L10I, I15V, G16A, K20M, L24F, E35D, M36I, R41K, K55R, I62V, L63P, A71V, I72L	B
	48-9016	9016-30908	DQ877628	PI	NA	I54V, V82A, L90M	L33F, K43KPQT, G73T	L10I, I13V, G16A, L24F, E34Q, R57K, Q61E, I62V, L63P, A71T, I72T, I93L	B
	48-9091	9091-30827	DQ877652	PI	NA	M46L, I54V, V82A, L90M	V11I, L33F, Q58E, G73S, L89V	L10I, I13V, L24F, N37D, K55R, D60DN, I62V, L63P, K70KN, A71I, I72M, V77I, C95L	B
	48-9102	9102-30908	DQ877691	PI	NA	M46I, I54V, I84V, L90M	G73S	L10I, Q18H, L19P, K20I, L24F, L33V, M36I, N37S, I62V, L63P, H69L, A71T, I72R, I93M	B
	48-9122	9122-30930	DQ877710	PI	NA	I54V, V82A, L90M	L33F, K43KT, F53L, G73S	L10I, I13V, I15V, K20R, L24F, E35D, M36I, K55R, I62V, L63P, A71V, I72V	B
	48-8006	8006-30527	DQ879051	PI	NA	M46L, V82A, L90M	L10F, Q58E, G73S, L89V	I15V, Q18H, K20I, L24F, R41K, L63P, A71V, I72ILM, I93L	B
Rosen-Zvi (2008)	77	03p77-2		SQV, IDV, NFV, RTV, APV, LPV	252	M46I, I84V, L90M	L33F, G73S	L5F, L10I, L24F, E34Q, R41K, F53Y, I62V, L63P, A71V, I72K, V77I, I93L	B
		05p77-3		SQV, IDV, NFV, RTV, APV, LPV, FPV	368	M46I, I54IL, I84V, L90M	L10F, L33F, G73S	L5F, I13IM, G16A, L24F, E34Q, R41K, F53Y, I62V, L63P, I64IM, A71L, I72K, V77I, I93L	B
		06p77-4		SQV, IDV, NFV, RTV, APV, LPV, FPV	429	M46I, I54L, I84V, L90M	L10F, L33F, G73S	L5F, I13V, G16A, L24F, E34Q, R41K, F53Y, I62IV, L63P, I64IM, A71L, I72K, I93L	B
		07p77-5		SQV, IDV, NFV, RTV, APV, LPV, FPV	475	M46I, I54L, I84V, L90M	L10F, L33F, G73S	L5F, I13V, G16A, L24F, E34Q, R41K, F53Y, I62IV, L63P, I64IM, A71L, I72K, I93L	B
Dau (2010)	09214A	09214A	GU581958	PI	NA	M46L, I54V, V82A, I84V, L90M	L33F, Q58E, G73S	P9PL, L10I, I13V, K20R, L24F, T31TI, E35DN, M36I, N37EQ, K55R, R57K, D60E, I62V, L63P, A71V, I72T	B
	10017A	10017A	GU581991	PI	NA	M46I, I54L, V82A, L90M	L33F, K43T, G73S	T4S, L10V, I13IV, I15V, G16A, L24F, I62V, L63P, A71I, I72R, V77VI, I93L	B
Jones (2012)	129273	129273	JN669462	PI	NA	M46I, I54V, I84V, L90M	L10F, G73T	I13V, I15V, Q18H, K20V, L24F, L33LM, M36L, N37P, Q61H, I62V, L63P, I66V, A71T, I72T, V77I, I93L	B
	140263	140263	JN669586	PI	NA	M46I, I54V, I84V, L90M	L33LI, G73T	L10I, T12TP, G16GA, L24F, E35D, M36ML, N37D, K55KR, I62V, L63P, H69HR, A71IT, I72K, V77I, I93L	B
	172184	172184	JN670281	PI	NA	M46I, I54V, V82A, L90M	L33F, G73ST	L10I, I13V, L24F, E35ED, M36MV, N37NT, R41K, K55R, R57RK, I62V, L63P, A71V, I93L	B
	178086	178086	JN670469	PI	NA	M46L, I54V, V82A, L90M	L33F, K43T, G73S	L10I, I13V, I15IV, L19LS, K20R, L24F, E35D, M36I, R41K, K55R, R57K, Q61N, I62IV, L63P, I66V, K70KT, A71V, I72IT, I85L, I93L	B
	196990	196990	JN671051	PI	NA	M46I, I54V, V82A, L90M	L33F, G73S	L10I, I15V, K20R, L24F, E35D, M36L, N37D, K55R, R57K, I62V, L63P, H69K, A71V, I72FL, V77I	B

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