<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation L23I
Rx >= 1 PI
IncludeMixtures No
References 19
Patients 96
Isolates 109
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Balotta (2000)CB-131CB-131AF252001PINAM46L, I54V, V82A, I84V, L90ML23I, Q58EQ2K, L10I, E35D, M36I, L63P, A71V, I93LB
Shulman (2000)CA1158CA11021AY798381IDV, SQV, NFV, RTV127I54V, V82A, L90ML23I, F53LL10I, E35D, M36V, R57K, D60E, I62V, L63P, A71V, I93LB
 CA1277CA4390AY798386IDV, NFV64 L23IK20KR, N37T, L63P, T74S, V77VI, V82I, I93LB
Gonzales (2001)CA1435CA3837AY030573IDV, SQV, RTV, NFV103V32I, M46I, V82A, L90ML23I, F53LL10V, T12S, L19Q, M36L, N37S, I62V, L63P, A71VB
 CA1800CA4836AY030718RTV, SQV120M46ML, I54V, V82A, I84IV, L90ML23IL10I, R41RK, R57K, L63P, A71VB
 CA1809CA4855AY030724NFV85 L23II13V, K14R, I15V, K20T, E35G, R41K, I64V, V77I, V82I, I93LB
 CA3910CA9686AY030913SQV, NFV, RTV162M46L, I54V, V82A, I84V, L90ML23IL10I, P39A, L63P, A71V, V77IB
 CA5750CA14288AY032140IDV, SQV, RTV157M46I, L76V, I84V, L90ML23I, F53LL10I, E35D, N37D, D60E, L63P, I64V, A71V, I93LB
Tural (2002)880418880418 RTV, IDV, SQV, NFV143I54V, V82A, L90ML23I, F53LL10V, I15V, K20R, M36I, N37D, R41K, I62V, L63P, I93LB
 880423880423 IDV, NFV, SQV120M46I, I54V, V82F, L90ML23IL10I, E35D, N37D, R41K, F53Y, L63P, A71T, I72V, V77I, Q92R, I93LB
 880814880814 SQV, NFV85M46I, L90ML23I, F53L, G73SL10I, K20I, N37H, R41K, L63P, A71V, V77IB
 881505881505 IDV, SQV, RTV138M46I, L76V, I84VL23I, F53LL10I, I13V, I15V, L19V, K20R, M36I, I62V, L63P, I64VB
Wu (2003)CA1277CA10012AF544453IDV, NFV70 L23IN37T, L63P, T74S, V77I, V82I, I93LB
 CA3910CA20414AF544536SQV, NFV, RTV219M46L, I54V, V82A, I84V, L90ML23IL10I, P39A, D60DE, I62IV, L63P, A71V, V77IB
 CA8022CA20534AF544609SQV310I54V, L90ML23I, N88DL10I, I13V, M36MI, N37ND, L63P, A71V, I72V, T74SB
 CA8355CA21281AF544615RTV, IDV, SQV, APV316V32I, M46I, I47V, I54V, L90ML23I, L33I, F53L, G73CL10I, E35D, M36I, I62V, L63P, I64V, I66L, A71X, I72MV, I93LB
 CA9429CA23150AF544618NFV202M46I, L90ML23ID60E, I62V, L63N, I64V, I72T, V77I, V82I, I93LB
Colonno (2004)RC-009-014-023014-02321 NFV, SQV, ATV68M46I, I84V, N88SL23IL10I, I13V, E35D, N37Y, R41K, L63X, A71T, V77I, L89MB
 RC-810024D24D11 NFV D30NL10F, L23I, N88DI13V, N37S, R41K, I62V, L63P, K70R, A71T, I93LB
 RC-009-007-064007-06421 NFV, SQV, ATV60M46I, I84V, L90ML23I, F53L, G73TL10X, I13V, K14R, I15V, G16A, L24F, E35D, N37X, I62V, L63P, I64V, I72X, V77I, I93L, C95FB
Rhee (2004)CA9752CA41282AY798494NFV111 L23I, Q58QEE35D, R41K, L63P, V77I, V82I, I93LB
Garcia-Bujalance (2005)GBS_45GBS_45AY872326SQV, RTV, LPV M46L, I54V, V82A, I84V, L90ML10FI, L23I, L33F, Q58EI13IV, E34EQ, I62V, L63P, A71V, I72VB
 GBS_04GBS_04AY872285RTV, NFV135M46LL23II13V, I15V, K20T, M36I, L63P, H69K, A71T, L89I, Q92RB
Non-B Workgroup (2005)TK2028TK2028 IDV, SQV, RTV207M46MI, I54V, L90LML23I, F53L, N88NDK14KR, E35ED, N37P, L63P, A71AVB
Rhee (2005)CA628CA17003AY796444SQV, IDV, RTV, Unknown, APV>152M46L, V82A, I84V, L90ML23I, Q58EL10I, D60E, Q61EK, L63P, A71T, I72TB
 CA1158CA33933AY796531IDV, SQV, NFV, RTV, APV, LPV214I54V, V82A, L90ML23I, L33F, F53LL10I, E35D, M36V, R57K, D60E, I62V, L63P, A71V, I93LB
 CA1263CA41214AY796570IDV, SQV, RTV427L90ML23I, F53L, G73SL10I, I62V, L63P, H69HY, A71T, V77I, I85VB
 CA1800CA13472AY796814RTV, SQV, Unknown>120M46L, I54V, V82A, I84V, L90ML23IL10I, R57K, L63P, A71V, Q92KB
 CA2251CA33641AY796909IDV, NFV238M46IL23I, L76EL10I, I13V, E35D, N37D, Q61N, I62IV, L63P, I64V, V77IB
  CA37811AY796910IDV, NFV288M46IL23I, L76EL10I, I13V, E35D, N37D, Q61N, I62V, L63P, I64V, V77IB
 CA5175CA37858AY797256IDV, SQV, RTV319V32I, M46L, I54V, V82A, L90ML23I, L33F, F53LI13V, K14R, K20R, M36I, L63P, I64V, A71VB
 CA5204CA33687AY797264NFV, SQV, RTV184I84V, L90ML23I, N88DG16A, K20R, M36I, R57K, Q61H, L63P, H69Q, A71I, I93MB
 CA8022CA24065AY797651SQV325I54V, L90ML23I, N88DL10I, I13V, M36I, N37D, L63P, A71V, I72V, T74SB
 CA8355CA33974AY797717RTV, IDV, SQV, APV, LPV398V32I, M46I, I47V, I50V, I54V, L90ML23I, L33I, F53L, G73CL10I, K20R, E35D, M36I, I62V, L63P, I64V, I66L, A71I, I72V, I93LB
 SWC-3636P3636-2284 NFV, SQV, RTV65M46L, L90ML23I, G73TL10I, T12E, L19I, M36I, I62V, L63P, R87K, I93LB
 CA9429CA33310AY797775NFV, Unknown>202M46I, L90ML23IL10LI, D60E, I62V, L63N, I64V, I72T, T74TS, V77I, V82I, I93LB
 CA17599CA41438AY798266RTV, IDV, LPV330M46L, I54V, L76V, V82AL23IL10I, I15V, I62V, L63V, H69R, A71V, I72K, L89M, I93LB
Baxter (2006)12-16261626-30328DQ875995PINAM46L, I54V, V82A, L90ML23IL10I, T12TS, K20R, M36MI, N37D, I62V, L63P, A71V, Q92R, I93LB
 12-19151915-30714DQ876008PINAM46I, I54V, L90ML10F, L23I, L33F, F53L, G73ST12E, R41K, Q61R, I62V, L63P, C67Y, A71V, I72L, V77VI, I93LB
 12-11721172-30415DQ876058PINAM46L, I54V, V82A, L90ML23I, L33F, Q58E, G73SL10I, N37T, D60E, I62V, L63P, A71V, I72K, I93LB
 12-40044004-30128DQ876161PINAM46I, I54V, L76V, V82AL23I, F53LL10I, R41K, D60E, I62V, L63P, A71V, I93LB
 12-20072007-30604DQ876238PINAV32I, I54V, L90ML23I, L33LI, M46V, F53L, Q58E, G73SL10I, I13IV, K20R, E35D, M36I, N37S, R57K, I62IV, L63P, I64V, A71V, V82IB
 12-22372237-30715DQ876249PINAM46I, I54V, L76V, V82F, L90ML23I, L33F, K43TL10I, I13V, E35D, M36I, N37NS, I62V, L63P, I64V, A71AV, I93LB
 12-23192319-30819DQ876417PINAI54V, V82A, I84V, L90ML23I, L33F, G73SL10I, I15V, N37Y, I62V, L63P, A71V, I72LB
 12-10831083-30429DQ876423PINAM46L, I54V, V82T, L90ML10F, L23I, L33F, K43T, F53LK20R, E35D, M36I, K55R, I62V, L63P, A71V, I93LB
 12-22172217-30730DQ876459PINAM46L, I54V, V82A, L90ML10F, L23I, K43T, Q58EI15V, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I93LB
 12-19201920-30529DQ876481PINAV32I, I47V, I54M, V82A, L90ML23I, L33F, K43T, G73S, L89VL10I, K14R, G16R, E34Q, E35D, M36L, N37D, I62V, L63P, A71L, I72L, V77I, I93LB
 12-13531353-30711DQ876492PINAM46L, I54V, V82A, L90ML23I, L33F, Q58EL10I, I13V, L19I, L24M, M36ML, N37D, K55R, I62V, L63P, H69Y, A71T, I72T, V75IB
 12-23592359-30814DQ876599PINAL90ML23I, G73SL10I, K45R, R57K, L63P, A71V, V77VI, I93LB
 12-14071407-30507DQ876789PINAM46L, I54V, L76V, V82A, I84IV, L90ML23I, L33FL10I, I13V, G16GA, L63P, H69Y, A71V, I72V, V77I, I93LB
 12-11521152-30701DQ876894PINAM46I, I50VL10F, L23I, L33F, F53L, G73GSI13V, G16GA, N37ND, L63P, V77I, I93LB
 12-11701170-30305DQ876942PINAI54V, V82A, L90ML23I, K43T, F53L, N88DL10I, K20R, E35D, M36I, R57K, I62V, L63P, A71VB
 12-19581958-30606DQ876990PINAI54V, L76V, V82FL23I, L33I, Q58EL10I, Q18E, K20KR, E34D, E35D, M36I, N37C, I62V, L63P, H69R, L89MB
 12-12601260-30318DQ877128PINAM46L, I54V, L76V, V82AL23I, Q58EL10IV, I15V, G16GA, L63A, A71V, I93LB
 12-30673067-30402DQ877206PINAM46I, L76V, V82F, L90ML23I, L33F, Q58EI13V, E35D, M36I, N37D, I62V, L63Q, I64VB
 12-30353035-30310DQ877215PINAI54V, V82A, L90ML23I, F53FLL10I, N37NS, R41RK, D60E, I62V, L63P, I64L, A71T, I72IV, V77I, I93LB
 48-11621162-30814DQ877267PINAM46L, I54V, L76V, V82AL23IL10I, I15V, K20R, E35D, M36I, N37D, R57K, Q61N, L63C, L89MB
 48-10441044-30617DQ877367PINAM46I, L76V, V82T, L90ML23I, F53L, Q58EL10I, I15V, K20R, E35D, M36I, N37D, K55R, R57K, D60E, I62V, L63P, A71V, I93LB
 48-11151115-30716DQ877380PINAM46I, I50IV, I54IM, V82A, L90ML23I, L33F, K43T, F53FLT4S, L10I, L63P, H69Q, A71V, I85IV, I93LB
 48-12471247-30610DQ877770PINAM46I, I54V, L76VL23I, L24I, F53L, Q58EL10I, T12P, L19LI, N37S, I62V, L63Q, I64V, H69R, A71V, V77I, L89M, I93LB
 48-26172617-30630DQ877907PINAI54V, V82A, I84V, L90ML23I, K43TL10I, T12E, L19V, K20R, E35D, M36IV, I62V, L63P, H69Q, A71I, Q92K, I93MB
 48-30033003-30225DQ877913PINAM46MI, I54V, V82A, I84VL23I, L24LI, F53FLL10I, I15V, G16GE, L19V, K20M, E35D, M36I, R41RK, K45N, K55KR, Q61QH, I62V, L63T, I64V, E65D, I72V, I85IV, T91SB
 48-30203020-30303DQ877930PINAM46I, I54L, L76V, L90ML10F, L23I, L33F, Q58E, G73S, L89VI13V, K20A, E34Q, E35D, M36I, K55R, R57K, I62V, L63P, A71V, I72LB
 48-30443044-30306DQ877956PINAM46L, I54V, V82A, I84V, L90ML23I, L33F, Q58E, T74PL10I, I13V, K14KR, G49GE, L63P, A71V, I93LB
 48-30723072-30326DQ877981PINAG48V, I54V, V82S, L90ML23I, Q58EL10I, I15V, K20R, M36I, N37D, G52GV, I62V, L63PB
 48-31163116-30321DQ878024PINAM46I, I50V, I54V, V82A, L90ML23IL10I, E35ED, M36V, N37D, R41K, L63P, A71V, I93LB
 48-31263126-30409DQ878034PINAM46L, I54V, V82A, L90ML23I, K43TL10I, T12P, I15V, D60E, I62V, L63P, L89LM, T91TS, Q92RB
 48-31283128-31125DQ878038PI, RTV, TPV>32M46MIL, I47IV, I54V, V82L, L90ML23I, F53LL10V, I13V, K20R, E35D, M36V, N37E, R57K, D60DE, I62V, L63P, A71IV, V77I, I93LB
  3128-40708DQ878037PI, RTV, TPV>64M46IL, I47IV, I54V, V82L, L90ML23I, F53FL, Q58QEL10V, I13V, K20R, E35D, M36V, N37E, R57K, D60DE, I62V, L63P, A71IV, V77I, L89LM, I93LB
 48-31753175-30422DQ878084PINAM46L, I54V, V82F, L90MV11I, L23I, L33F, F53LL10I, I13V, K43S, I62V, L63P, A71V, I72V, T74A, V77I, I93LB
 48-32253225-30521DQ878132PINAM46L, I54V, V82A, L90ML23I, L33F, K43T, F53L, T74PL10I, I13V, L19I, K20R, E35D, M36I, N37T, K55R, I62V, L63T, C67E, I72T, L89MB
 48-32543254-30610DQ878158PINAV32I, M46I, I47A, L90ML23I, F53FLL10I, I15V, K20T, E35N, M36I, N37D, I62V, L63P, I66IV, A71L, I72V, V77I, I93LB
 48-32733273-30701DQ878178PINAM46I, I54V, L76V, V82AL23I, Q58EL10I, I15V, K20R, M36I, R41K, G51A, L63P, H69R, A71V, I93LB
 48-32863286-30707DQ878192PINAM46I, I54V, L76V, V82F, L90ML23I, F53L, Q58EL10I, K14R, I15V, I62V, L63P, A71V, I93LB
 48-32943294-30729DQ878199PINAM46L, I54V, L76V, V82F, L90ML23I, L33F, Q58EL10I, I13V, K14KR, D60DN, Q61QH, L63P, C67DE, A71AV, V77I, L89M, I93LB
 48-40784078-30225DQ878307PINAM46L, I54L, V82F, I84V, L90ML23I, L33FL10V, I13V, L19V, E35D, M36L, N37D, F53FY, Q61QE, I62V, T74E, L89MB
 48-41554155-30327DQ878389PINAM46I, I47V, I54V, V82AL10F, L23I, F53LR41K, I64V, A71V, I93LB
 48-41964196-30519DQ878429PINAM46L, I54V, V82A, L90ML23I, K43T, F53FL, Q58EL10I, L63P, A71V, I93ILB
 48-42144214-30507DQ878447PINAM46L, I54V, V82A, L90ML23I, L33F, Q58E, G73GS, T74TPL10I, I13V, L24F, I62V, L63P, A71V, I93LB
 48-42484248-30617DQ878481PINAV32I, M46I, I47V, I54L, L90ML23I, L33F, F53L, G73CI13V, E35D, M36L, L63P, A71AT, I72IT, V82I, I93LB
 48-42564256-30715DQ878488PINAM46I, I54V, V82F, L90ML23I, F53FL, Q58EL10I, K20R, E35D, M36I, K55R, R57RK, I62V, L63P, I64IL, I66V, H69HR, A71T, I72V, V77I, I93L, C95FB
 48-60716071-30604DQ878669PINAM46I, L76V, V82F, L90ML23I, L33FL10I, T12K, I13V, K14KR, I62V, L63P, T74A, V77I, L89MB
 48-60886088-30603DQ878683PINAM46I, I54V, L76V, V82F, I84V, L90ML23I, L33F, G48E, Q58EL10I, I13V, E34K, N37T, I62V, L63P, V77I, L89MB
 48-61086108-30930DQ878700PINAM46L, G48A, I54V, V82AL23I, F53L, Q58EL10I, I15V, K20R, E21K, E35D, M36I, N37D, K55R, R57K, I62V, L63V, G68E, H69K, A71V, I93MB
 48-61186118-30923DQ878704PINAM46I, I50V, I54V, V82A, L90ML23I, L33F, K43KT, N88DL10I, I13V, E34Q, M36MI, I62V, L63P, A71V, I72M, C95FB
 48-61216121-30807DQ878707PINAM46I, I54V, L76V, V82A, L90ML23IL10I, T12P, K55R, R57K, D60E, Q61E, I62V, L63P, A71V, I93LB
 48-62266226-30730DQ878793PINAM46L, I54V, L76V, V82F, L90ML23IL10I, I15V, D60E, I62V, L63P, A71V, I93LB
 48-70047004-30805DQ878892PINAM46L, I54V, V82AL23I, L24I, F53LL10I, I15L, L19V, R41K, K55R, L63P, A71I, T74S, V77IB
 48-70647064-30729DQ878932PINAM46I, I50V, I54V, L90ML10F, L23I, G73S, L89VI15V, K20V, E35D, M36I, N37D, D60E, Q61H, L63P, A71V, I72M, I85V, Q92K, I93LB
 48-93149314-30922DQ877646PINAM46L, I54V, V82A, L90ML23I, Q58ER8Q, L10V, L19I, E35D, M36I, N37S, R41K, I62V, L63P, A71V, I72IV, I93LB
 48-93189318-30923DQ877647PINAM46I, I54V, L76V, V82F, L90ML23I, Q58EL10I, K14R, K20R, E35D, M36I, N37D, I62V, L63P, I64V, A71V, I93LB
Rhee (2006)CA1834CA63811 RTV, NFV, IDV, APV, LPV, ATV450I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, R57K, D60E, L63P, A71V, I93LB
Rosen-Zvi (2008)1700p17-1 SQV, IDV, NFV, RTV199M46I, L90ML23I, F53L, G73SL10I, I13V, I15IV, K20KR, I62IV, L63P, H69R, A71V, V77IB
  01p17-3 SQV, IDV, NFV, RTV, APV257M46I, I54M, L90ML23I, L33F, F53L, G73SL10I, I13V, I15V, K20R, L63P, H69R, A71V, V77IB
Rhee (2009)CA1290CA48089FJ983142SQV, IDV, NFV, RTV, APV394M46I, I54M, V82A, L90ML23I, L33F, K43T, F53L, G73TL10I, I15V, Q18H, K20R, E35D, M36I, N37D, K55R, D60E, L63P, I64V, C67F, H69K, I72IV, I93LB
 CA5204CA50796FJ983179NFV, SQV, RTV, LPV304I84V, L90ML10LF, L23I, N88DI13IV, G16A, K20R, M36I, R57K, Q61H, L63P, H69Q, A71I, I93MB
Dau (2010)06497A06497AGU581753PINAM46I, I50V, L76V, L90ML23IK14R, I15V, K20R, E35D, M36I, N37E, R41K, I62V, L63P, I64V, A71V, V82I, I93LB
 06725B06725BGU581775PINAI54V, V82A, L90LML23IL10I, T12P, K14KR, L19V, K20R, M36MI, R41K, L63P, A71T, V77I, I93LB
 06883A06883AGU581794PINAM46L, I54V, L76V, V82FL23I, L33FL10I, I13V, E35D, N37S, I62V, L63P, I64V, A71T, T74S, V77I, I93LB
 07763A07763AGU581867PINAM46L, I54V, V82A, L90ML10FI, L23IR57K, I62IV, L63P, I64IV, H69HY, A71V, I72IV, I93LB
 10962A10962AGU582026PINAM46MI, N88SL23IL10I, I13V, L63P, I64IM, V77I, I93LB
Knops (2010)ID0237ID0237-GT2GU271155Unknown, LPV>72M46L, L76V, V82F, L90ML23I, L33F, Q58EL10I, I13V, M36L, K55KR, I62V, I64VB
Rhee (2010)CA1834CA59294GQ211180RTV, NFV, IDV, APV, LPV, ATV446I54V, L76V, V82AL10F, L23I, L33F, Q58EI13V, R57K, D60E, L63P, A71V, I93LB
 CA14383CA63831 RTV, IDV, SQV, ATV518M46I, I54IV, I84V, L90ML23I, G73SL10LI, I13L, N37D, L63P, I66IV, C67CF, A71V, I72V, V77I, I93LB
 CA17599CA64053GQ211895RTV, IDV, LPV, APV, Unknown>415M46L, I54V, L76V, V82AL23I, F53LL10I, I15V, I62V, L63V, H69R, A71V, I72K, L89M, I93LB
Jones (2012)131910131910JN669506PINAL90ML23I, G73CL10I, N37D, R41RK, I62V, L63P, C67Y, Q92KB
 176684176684JN670408PINAM46L, I54V, V82A, L90ML23I, F53L, Q58QEL10V, N37D, K55R, D60E, L63P, A71V, V77VI, I85V, I93LB
 192523192523JN670855PINAM46L, I54V, V82AL23I, L24I, L33F, F53L, Q58EL10I, K20R, M36I, N37S, I62V, L63P, A71VB
Mollan (2012)MK85MK85w163 RTV, ATV163M46I, I47V, I54V, L76V, V82AL23I, Q58EL10V, R41K, K55R, D60E, I62V, L63P, A71V, V77I, I93LB