Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	B
Gene	PR
Mutation	V11L
Rx	>= 1 PI
IncludeMixtures	No

References	7
Patients	65
Isolates	70

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Rhee (2005)	CA622	CA37880	AY798413	IDV, SQV, RTV, LPV	387	M46I, I54V, V82T, I84V, L90M	L10F, L33F, G73S, L89V	V11L, G16A, L19I, R41K, L63P, A71V, T91S, I93L	B
	CA1341	CA48551	AY796641	IDV, SQV, RTV, NFV, APV, LPV	304	M46L, I54V, V82A, L90M	L33F, Q58E, G73A	L10I, V11L, G16A, L19I, R41K, K55R, D60E, I62V, L63P, I64M, A71I, I72M, V77I, I93L	B
	CA1590	CA42641	AY796792	IDV, SQV, RTV, NFV, APV	413	M46I, I50V, I54V, V82L, L90M	L33F, G73T, L89V	L10I, V11L, T12E, I13V, L19IM, M36I, R41K, L63P, A71V, V77I, I93L	B
	CA4497	CA33389	AY797111	IDV, SQV, NFV, RTV, LPV, APV	310	I54V, V82T, I84V	L89V	L10I, V11L, I13V, I15V, K20I, E35D, M36I, N37D, D60E, L63P, K70E, A71I, Q92K	B
		CA34161	AY797112	IDV, SQV, NFV, RTV, LPV, APV	350	I54V, V82T, I84V	L89V	L10I, V11L, I13V, I15V, K20I, E35D, M36I, N37D, D60E, L63P, K70E, A71I, Q92K	B
		CA42653	AY797113	IDV, SQV, NFV, RTV, LPV, APV	417	I54V, V82T, I84V	L89V	L10I, V11L, I13V, I15V, K20I, E35D, M36I, N37D, D60E, L63P, K70E, A71I, Q92K	B
Baxter (2006)	12-1001	1001-30227	DQ875949	PI	NA	G48GASW, I54T, V82A	L33F	L10I, V11L, G16A, L19V, K20R, E34Q, E35D, M36I, N37E, D60E, L63P, I64IL, A71V, V77I, L89I, I93L	B
	12-1321	1321-30402	DQ875968	PI	NA	I54M, I84V, L90M	L10F, Q58E, G73S, L89V	V11L, T12S, I13V, K14R, I15V, Q18H, L19Q, K20I, E34Q, M36MI, N37S, G51A, D60E, L63P, A71V, P79Q	B
	12-1093	1093-30224	DQ875992	PI	NA	G48V, I50V, I54V, V82S	L89V	L10I, V11L, K14R, I15V, K20I, M36I, R41K, I62V, L63P, A71V, T74S, I85V, T91TS	B
	12-4079	4079-30224	DQ876172	PI	NA	M46I, I84V, L90M	L33I, G73S	L10I, V11L, I13V, K14R, A22V, E35D, M36I, N37D, I62V, L63P, A71V, I72V	B
	12-1479	1479-30731	DQ876190	PI	NA	I54V, V82A, L90M	L10F, K43T, L89LV	V11L, T12K, I15V, Q18H, L19I, K20V, E21ED, E35D, M36I, N37D, R57K, I62V, L63P, A71I, I85V, Q92K, I93L	B
	12-1005	1005-30304	DQ876196	PI	NA	M46I, I54L, V82T, I84V, L90M	L33F, G73S	L10I, V11L, I13V, E34Q, N37S, K55R, R57RK, L63P, A71V, I93L	B
	12-1643	1643-30312	DQ876198	PI	NA	M46I, I54V, L76V, I84V, L90M	L33F, L89V	L10I, V11L, I13V, G16A, N37D, K55R, D60E, L63P, H69Y, A71V, I72FL, V77VI, I93L	B
	12-1322	1322-30423	DQ876328	PI	NA	M46I, I54V, V82C, I84V, L90M	L33F, G73S, L89V	L10I, V11L, G16A, E34Q, K55R, R57K, L63P, H69Q, K70E, A71V, I72L, T91S, I93L	B
	12-2376	2376-30821	DQ876348	PI	NA	M46I, I50L, I54V, V82L, L90M	L33F, G73C, T74P	L10I, V11L, I13V, G16A, K20R, E35D, M36I, N37D, R41K, I62V, L63P, A71V, L89A, I93L	B
	12-1075	1075-30314	DQ876398	PI	NA	V32I, I47V, I54M, L90M	L10F, Q58E, G73GS, L89V	V11L, I13V, K20T, E35D, M36I, N37D, D60E, Q61E, L63P, A71I, V77VI, I93L	B
	12-1082	1082-30328	DQ876422	PI	NA	I54V, V82T, I84V, L90M	G73S, L89V	L10I, V11L, I13V, Q18H, K20V, M36I, N37D, L63P, A71V	B
	12-1340	1340-30421	DQ876444	PI	NA	V32I, M46I, I47V, I54M, L90M	L33F, K43T, G73S, L89V	L10V, V11L, I13V, K14M, Q18H, E34Q, N37S, Q61H, I62V, L63P, A71I, V77I, V82VI, I93L, G94D	B
	12-2257	2257-30818	DQ876574	PI	NA	I54L, I84V, L90M	L33F, T74P	L10I, V11L, I13V, K20R, E34Q, E35D, M36I, N37D, D60E, I62V, L63P, A71V, I93L	B
	12-2161	2161-30708	DQ876586	PI	NA	M46I, I54V, V82CG, I84IV, L90M	F53FL, Q58QE	L10I, V11L, I13V, K20V, K55KR, I62V, L63P, A71V, Q92QKR	B
	12-2297	2297-30812	DQ876657	PI	NA	M46I, I54AV, V82A, I84V	L10F, L89V	V11L, I13V, L19Q, K20I, M36I, L63P, H69K, K70R, A71T, T74S, T91S	B
	12-1598	1598-30711	DQ876702	PI	NA	V32I, M46I, I54V, L90M	L10F, K43T, F53L	V11L, K20V, E35D, M36I, N37K, L63P, A71L	B
	12-1262	1262-30324	DQ876710	PI	NA	V32I, M46I, I47V, I54L, V82C, L90M	K43T, L89V	L10I, V11L, I15V, L19LQ, K20I, E35D, M36I, N37ND, R41K, L63P, A71V, I85V, Q92K	B
	12-3157	3157-30515	DQ876726	PI	NA	M46IL, I54V, I84V, L90M	G73S, L89V	L10I, V11L, K14KR, I15V, K20V, M36MI, R41RK, D60E, I62V, L63P, A71V, I72L, P79A, I85V	B
	12-1402	1402-30702	DQ876770	PI	NA	V32I, M46I, I47V, I54M, L90M	K43T, G73S, L89V	L10I, V11L, I13V, L19I, K20R, E35D, M36I, N37H, L63P, A71I, I72E, V77I, V82I, I93L	B
	12-1435	1435-30728	DQ876834	PI	NA	I54M, I84V, L90M	L33F, G73S, L89V	V11L, I13V, R57K, D60E, I62V, L63P, I66F, A71V, I72M, V77I, R87S	B
	12-1497	1497-30620	DQ876892	PI	NA	I54V, V82F, L90M	F53L	L10I, V11L, I13V, I15V, K20V, E35D, M36I, N37ND, R41K, D60E, I62V, L63P, I64V, A71V	B
	12-1940	1940-30521	DQ877026	PI	NA	M46L, I54V, I84V, L90M	L33F, T74P	L10I, V11L, I13V, R41K, K55KR, D60E, L63P, A71V, V77VI, I93L	B
	12-1736	1736-30418	DQ877138	PI	NA	G48AS, I54V, V82A, L90M	K43T, G73S	L10I, V11L, T12E, I15V, K20I, E35D, M36I, I62V, L63P, A71V, I72R, I85IV	B
	12-2062	2062-30623	DQ877142	PI	NA	M46I, I47V, I54L, L76V, I84V, L90M	G73S, L89V	L10I, V11L, I13V, I15V, Q18H, K20I, E34Q, E35D, M36I, N37ND, D60E, I62V, L63P, A71L, I72L, I93L	B
	12-3094	3094-30509	DQ877195	PI	NA	M46I, I47V, I54V, I84V, L90M	L10F, Q58E, G73S	V11L, I13V, K14R, I15V, K20I, M36I, R41K, D60E, I62V, L63P, A71V, I72L, I85IV	B
	12-3024	3024-30306	DQ877237	PI	NA	M46I, I54V, V82A, I84V, L90M	L33F, T74P	L10I, V11L, I13V, N37D, R41K, I62V, L63P, A71V, I72V, V77VI, I93L	B
	48-2201	2201-30331	DQ877854	PI	NA	I54L, I84V, L90M	L33F, G73A	L10I, V11L, I13V, N37H, R41K, K45R, L63P, A71V, V77I, I93L	B
	48-3019	3019-30812	DQ877929	PI	NA	M46L, I54V, V82A, L90M	L10F, L33I, Q58E, L89V	T4PS, V11L, I13V, L19LV, K20I, E35D, M36I, L63P, A71V, T91TCS, I93L	B
	48-3057	3057-30325	DQ877969	PI	NA	M46I, I54M, L90M	L33F, Q58E, G73C	L10I, V11L, I13V, K14KR, K20T, K55R, R57K, Q61E, I62V, L63E, A71T, I72T, V77I, V82I	B
	48-3074	3074-30411	DQ877983	PI	NA	M46I, I54V, V82T, I84V, L90M	V32I_RR, L33F, G73S, L89V	L10V, V11L, I13V, L19V, K20R, M36L, R57K, L63P, A71V	B
	48-3136	3136-30404	DQ878047	PI	NA	M46L, I54V, V82A, I84V, L90M	L33F, G73S, L89V	L10I, V11L, I13V, K14RT, G16GA, E34EQ, I62V, L63P, A71V, I72E, V77I, P79S	B
	48-3176	3176-30425	DQ878085	PI	NA	I47V, G48V, I54M, L76V, V82C, L90M	F53L, G73A, L89V	L10I, V11L, I13V, G16A, K20V, E34Q, N37D, L63P, H69Y, A71V, V77I, I93L	B
	48-3188	3188-30505	DQ878096	PI	NA	V32I, M46I, I47V, I54M, V82A, L90M	L33F	L10I, V11L, I13V, E34Q, N37D, L63P, I66IV, A71IL, V77I, I93L	B
	48-3199	3199-30507	DQ878109	PI	NA	M46I, I47V, I54L, I84V, L90M	G73T	L10I, V11L, I15V, Q18H, L19P, K20I, A22V, E34Q, M36I, K55R, L63P, I64V, A71V, I72L, I85V	B
	48-3250	3250-30627	DQ878154	PI	NA	I54V, V82A, L90M	L33IV, F53FL, G73S, L89V	L10V, V11L, I13V, K20M, A22V, M36I, R41K, K55KR, D60E, Q61N, I62V, L63P, A71I, I72T, I93L	B
	48-4047	4047-30625	DQ878280	PI	NA	M46I, I54V, V82T, I84V, L90M	Q58E, G73S, L89V	L10I, V11L, I15V, G16A, K20IT, E21Q, M36MI, R41K, D60E, Q61D, L63P, A71V, I72T, I85V, T91CS, I93L	B
	48-4104	4104-30224	DQ878334	PI	NA	M46I, I54V, V82A, I84V, L90M	L33F, F53FL, Q58E	T4S, L10I, V11L, I13V, G16E, L19I, M36I, Q61R, L63T, L89I, T91S	B
	48-4129	4129-30318	DQ878360	PI, RTV, TPV	>1	V32I, M46I, I47V, I54L, I84V, L90M	L33F, F53FL, Q58E, T74P	L10I, V11L, I13V, K20R, E34Q, E35D, M36I, R41Q, K55KR, L63P, A71V, I72V, V77I, I93L	B
	48-4163	4163-30403	DQ878396	PI	NA	M46I, I54V, I84V, L90M	L33I, Q58E, T74P	L10I, V11L, I13V, Q18H, A22V, E35D, M36I, N37D, I62V, L63P, H69R, A71V, Q92K	B
	48-4228	4228-30430	DQ878461	PI	NA	M46I, I54V, V82T, I84V, L90M	K43T	L10I, V11L, I13V, G16A, N37D, F53W, L63P, I64V, A71V, T91S	B
	48-4237	4237-30508	DQ878468	PI	NA	M46I, I54V, I84V, L90M	G73T	L10I, V11L, I15V, K20I, E35D, M36I, I62V, L63P, A71V, I85V	B
	48-4259	4259-30530	DQ878491	PI	NA	V32I, M46I, I47V, I54M, I84V, L90M	L33F	L10I, V11L, N37S, L63P, A71L, I72IV, V77I, I93L	B
	48-6015	6015-30317	DQ878612	PI	NA	M46I, I54V, I84V, L90M	L10F, G73S	V11L, I13V, K14R, I15V, K20I, I62V, L63P, A71V, I72L	B
		6015-30904	DQ878614	PI, RTV, TPV	>24	M46I, I54A, I84V, L90M	L10FI, G73S, L89V	V11L, I13V, K14KR, I15V, K20I, L33V, I62V, L63P, A71V, I72L	B
		6015-40805	DQ878613	PI, RTV, TPV	>72	M46I, I54A, I84V, L90M	K43KT, G73S, L89V	L10IV, V11L, I13V, K14R, I15V, K20I, L33V, D60DE, I62V, L63P, A71V, I72L	B
	48-6062	6062-30728	DQ878660	PI	NA	M46I, I47IV, I54V, V82T, I84V, L90M	G73ST, L89LV	L10I, V11L, I15V, G16A, L19V, K20I, M36I, L63P, A71V, I72L, I85V	B
	48-6176	6176-30710	DQ878748	PI	NA	I54V, V82T, I84V, L90M	L10F, L89V	V11L, T12P, I13V, Q18H, K20I, M36I, N37D, R41K, K55R, I62V, L63P, A71V, T74S, T91S, Q92K	B
	48-7034	7034-30812	DQ878913	PI	NA	M46I, I54V, L76V, I84V, L90M	L33I, G73S, L89V	L10I, V11L, I13V, I15V, K20I, M36I, K55KR, R57RK, I62V, L63P, A71V, I72M	B
	48-9036	9036-30825	DQ877498	PI	NA	M46I, I54V, I84V, L90M	L10F, G73S	V11L, T12P, I15V, G17E, Q18H, K20I, M36MI, L63P, A71V, I72L, I85V, I93L	B
	48-9255	9255-30911	DQ877606	PI	NA	M46I, I47V, I54L, I84V, L90M	L10F, L33F, K43KT, T74P	V11L, I13V, E34Q, I62V, L63P, H69R, A71V, I72V, V77VI, I93L	B
	48-8021	8021-30806	DQ879064	PI	NA	M46I, I47V, I54M, I84V, L90M	L10F, K43T, G73S, L89V	V11L, T12N, I15V, L19LP, K20I, E35N, M36I, N37E, I62V, L63P, A71I, I72KR, V77I, I85V, I93L	B
Cardoso (2009)	3095	BRGO3095	FJ638442	PI	NA	I50V, I54V, V82A, L90M	K43T, F53L, G73A, L89V	L10IV, V11L, I13V, I15V, G16A, L19I, K20I, E35D, M36I, K55R, D60E, I62V, L63P, A71V	B
	3124	BRGO3124	FJ638456	PI	NA	M46I, I54V, L76V, I84V, L90M	L33F	L10I, V11L, K20R, E34N, E35D, M36I, R41K, K55R, R57K, D60E, I62V, L63P, A71V, I72T, I93L	B
Rhee (2009)	CA1524	CA63895	FJ983143	SQV, RTV, APV, LPV	429	G48M, I54V, V82A, I84V	F53L	L10I, V11L, I13V, K14KR, A22V, E35D, M36I, N37D, I62V, L63P, A71V, T74S, T91S, Q92K	B
	CA1590	CA57673	FJ983145	IDV, SQV, RTV, NFV, APV	467	M46I, I50V, I54V, V82L, L90M	L33F, G73T, L89V	L10I, V11L, T12E, I13V, Q18QH, L19M, M36I, R41K, L63P, A71V, V77I, I93L	B
Dau (2010)	06500A	06500A	GU581756	PI	NA	M46I, I54V, L76LV, V82VFI, L90M	L33I, G73C, L89V	L10I, V11L, I13V, K20V, M36I, P39T, I62V, L63P, I64V, T74S, I93IL	B
	06981A	06981A	GU581807	PI	NA	M46I, I54V, V82A	L10F, L89V	V11L, I13V, L19Q, K20I, M36I, L63P, H69K, K70R, A71T, T91S	B
	07893A	07893A	GU581880	PI	NA	I54M, L76V, I84V, L90M	L33I, G73S, L89V	L10I, V11L, I13V, Q18H, K20V, M36IL, I62V, L63P, A71IV	B
	08255A	08255A	GU581902	PI	NA	I54A, V82A, L90M	L33F, K43T	L10I, V11L, I13V, K14KR, I15V, K20R, E34HKNQ, E35D, M36I, N37NI, R41K, D60E, I62V, L63PQ, I64V, H69HY, A71V, Q92K, I93L	B
	09065A	09065A	GU581957	PI	NA	I54A, V82A, L90M	L33F, K43T	L10I, V11L, I13V, K14KR, I15V, K20R, E34N, E35D, M36I, R41K, D60E, I62V, L63PQ, I64V, H69HY, A71V, Q92K, I93L	B
	09756A	09756A	GU581981	PI	NA	I54A, V82A, L90M	L33F, K43T	L10I, V11L, I13V, K14KR, I15V, K20R, E34N, E35D, M36I, P39PS, R41K, D60E, I62V, L63P, I64V, H69Y, A71V, Q92K, I93L	B
	10025A	10025A	GU581992	PI	NA	M46I, I54V, V82A, I84V, L90M	L33F, T74P	L10I, V11L, I13V, N37D, R41K, I62V, L63P, A71V, I72V, V77VI, I93L	B
Knops (2010)	ID1318	ID1318-GT2	GU271163	SQV, NFV, IDV, APV, LPV	42	M46I, I54V, L76V, L90M	G73S, L89V	L10I, V11L, I13V, I15V, L19Q, K20I, E35D, M36I, D60E, I62V, L63P, A71V, I93L	B
Rangel (2010)	HIV249b	HIV249b	GU807507	PI	NA	V32I, I47V, I54L, I84V, L90M	L33F, T74P	L10I, V11L, I13V, G16A, K20R, E35D, M36I, K55N, R57K, I62V, L63P, A71V, I72V, V82I	B

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