Protease Inhibitors

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Protease Inhibitors

Subtype	B
Gene	PR
Mutation	L10R
Rx	>= 1 PI
IncludeMixtures	No

References	19
Patients	45
Isolates	60

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Condra (1996)	pt-A	ptAW12		IDV	12	M46I		L10R, R57K, I64V	B
		ptAW24		IDV	24	M46I, V82T, I84V		L10R, T12A, R57K, L63P, I64V	B
		ptAW40		IDV	40	M46I, V82T, I84V	L24I	L10R, T12I, N37D, L63P, A71V	B
		ptAW52		IDV	52	M46I, I54V, V82T	L24I, G73S	L10R, K20I, R57K, L63P, A71V	B
Gatanaga (1999)	Gat-NR1	agaNR1	AB020916	IDV, NFV	72	V82T		L10R, I62V, L63P, A71T, V77I, I93L	B
Zolopa (1999)	CA632	CA3136	AF085106	IDV	60	M46L, V82T, L90M		I3X, L10R, L63P, A71V, V77I, I93L	B
Bacheler (2000)	LB3-P69	P69-24		IDV	22			L10R, E35D, R57K, L63P, K70R	B
		P69-32		IDV	30			L10R, E35D, R57K, L63P, K70R	B
		P69-39		IDV	37		L24I	L10R, E35D, R57K, L63P, K70R	B
	LB4-P145	P145-43		IDV	24	M46L		L10R, K14R, R41K, L63P, I64V, K70R, V77I	B
		P145-55		IDV	36	M46L		L10R, K14R, R41K, L63P, I64V, K70R, V77I	B
	LB3-P20	P20-24		IDV	24	M46L, V82T		L10R, R57K, L63P, V77I, I93L	B
		P20-27		IDV	27	M46L, V82T		L10R, R57K, L63P, A71V, V77I, I93L	B
		P20-58		IDV	58	M46L, V82T		L10R, R57K, L63P, A71V, V77I, I93L	B
		P20-70		IDV	70	M46L, V82T		L10R, R57K, L63P, A71V, V77I, I93L	B
Baxter (2000)	GART-NG131	GART-131		Unknown, IDV	NA	M46L, V82T		L10R, N37T, L63P, V77I, I93L	B
Falloon (2000)	JF10	JF10-(-)1w	AF227703	IDV, SQV	68	M46I, V82T, L90M	G73S	L10R, N37D, I62V, L63P, A71V, V77I, I93L	B
		JF10-12w	AF227704	IDV, SQV, APV	80	M46I, V82T, L90M	G73S	L10R, N37D, I62V, L63P, A71V, V77I, I93L	B
Rousseau (2000)	MNR5	MNR4062	AJ405950	IDV, SQV, RTV, NFV	122	M46I, I84V, L90M	G73C	L10R, Q18H, N37S, I62V, L63P, I64V, I66V, I72V, V77I, I93L, C95F	B
Shulman (2000)	CA632	CA9441	AY798356	IDV, SQV, RTV	119	M46L, G48EV, I54IV, V82T, L90M	F53FL	L10R, G16A, L63P, A71V, I72IV, T74TS, V77I, I93L	B
Gonzales (2001)	CA1447	CA3864	AY030585	IDV	99	M46I, V82T, L90M		L10R, I13V, K14KR, L63P, I64V, A71AV, V77I, I93L	B
	CA1544	CA4416	AY030661	NFV, SQV, RTV	64	D30N, I84IV, L90M	N88D	L10R, T12P, K14R, L63P, A71T, I72T, V77I, I93L	B
	CA2076	CA7686	AY030785	IDV, NFV	52	M46L, L90M		L10R, E35G, M36I, R57K, Q61E, I62V, L63P, E65D, A71V, I93L	B
	CA5611	CA13953	AY032078	IDV, NFV	199			L10R, E35D, N37E, L63P, A71T, V77I, Q92K	B
	CA5751	CA14289	AY032141	IDV	105	M46I		L10R, T12A, L63P, I64V, I72IV, I93L	B
Kempf (2001)	DK-5394	DK-5394		IDV, NFV	93	M46L		L10R, L63P, A71T, I72T, V77VI, I93IL	B
	DK-5605	DK-5605		IDV, NFV	104	M46MI, L90M		L10R, L63P, I64V, V77I, I93L	B
Monno (2003)	ML_Pat70	ML_Pat70		PI	NA	M46L, L90M		L10R, L63P, C67Y, H69K, A71V, I93M	B
	ML_Pat83	ML_Pat83		PI	NA	V82T, I84V		L10R, T12I, R41K, K55R, I62V, L63P, H69T, A71T, V77I	B
Colonno (2004)	RC-009-017-078	017-07821		NFV, SQV, ATV	28	D30N, I54L, L90M	N88D	L10R, E35D, M36I, N37D, K45R, L63P, H69Q, A71V, I93L	B
Gomez-Carrillo (2004)	98905	98905	AY365589	PI	NA	M46I, L90M	G73C	L10R, T12K, I13V, L19I, K20I, E35D, I62V, L63P, I64V, I72V, V77I	B
Garcia-Bujalance (2005)	GBS_42	GBS_42	AY872323	RTV, NFV, SQV, LPV		I47V, G48M, I54L, V82A, I84V, L90M	L33F, F53L	P9S, L10R, K14N, I15K, E34Q, N37D, L63P, A71V, V77I, I93L	B
Rhee (2005)	CA632	CA1204	AY351708	IDV, SQV, RTV	84	M46L, G48V, V82T, L90M		L10R, L63P, A71V, T74TS, V77I, I93L	B
	CA1543	CA7985	AY796766	Unknown, SQV, NFV, IDV, RTV	>90	M46I, I84V, L90M		L10R, L63P, I64V, V77I, I93L	B
	CA2076	CA41194	AY796864	IDV, NFV, SQV, RTV	284	M46L, I54L, I84V, L90M		L10R, I13IV, K14E, L19V, K20T, E35G, M36I, R57K, Q61E, I62V, L63P, I64V, E65N, A71V, P79A, Q92K, I93L	B
	CA7126	CA17603	AY797540	IDV	82	M46I, L90M		L10R, K20I, E35D, M36I, N37S, R57K, I62V, L63P, I64V, I72X, I93L, C95F	B
		CA24237	AY797541	IDV	112	M46I, L90M		L10R, I15IV, K20I, E35D, M36X, N37S, R57K, I62V, L63P, I64V, I93L, C95F	B
	CA9684	CA23695	AY797803	IDV, SQV, RTV	276	M46L, I84V, L90M		L10R, I13V, N37S, D60DE, I62V, L63P, I64V, V77I	B
	SWC-5944	5944-4336		IDV	159	M46I, I84V		L10R, I13V, Q18QH, K20T, Q61E, I64V, I66F, H69R, V77I	B
Baxter (2006)	12-1421	1421-30331	DQ876015	PI	NA	D30N, M46L, I54L, L90M	V32V_W, N88D	L10R, I15V, L19Q, K20T, R41K, K55KR, L63P, K70R, A71V, V77I	B
	12-2077	2077-30609	DQ876018	PI	NA	V32I, M46I, I47V, I54M, V82T, L90M	V11I	L10R, I13V, K20I, L33V, K55R, I62V, L63P, A71L, I72L, Q92R	B
	12-1489	1489-30320	DQ876042	PI	NA	M46I, I47V, I54V, V82T, L90M		L10R, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I72V, I93L	B
	12-4048	4048-30714	DQ876154	PI	NA	M46L, L90M	G73C	L10R, I15V, L19P, K20I, E35G, M36L, N37T, P39S, K55R, Q61D, I62V, L63P, C67L, A71T, I72T, T74S, Q92K	B
	12-1080	1080-30414	DQ876420	PI	NA	M46LV, L76V, I84V	V11VI, L89V	L10R, T12P, I13V, L19M, K20I, E34EQ, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71I, T91A, I93L	B
	12-1786	1786-30506	DQ876684	PI	NA	V32I, M46I, I47V, I54M, V82T, L90M	L89V	L10R, I13V, L19T, K20M, E35E_E, M36I, L63P, A71I	B
	12-3069	3069-30417	DQ876733	PI	NA	M46I, I84V, L90M	L33F, Q58E	L10R, T12P, I13V, E35D, N37S, K55R, R57K, I62V, L63P, H69R, V82VI, T91S, C95F	B
	12-3200	3200-30716	DQ877186	PI	NA	M46I, I54V, V82T, L90M	K43T	L10R, L19I, K20R, E35D, M36I, K55R, R57K, L63P, A71V, V77I, Q92K, I93L	B
	48-1083	1083-30708	DQ877340	PI	NA	M46I, I54IT, L90M	G73C	L10R, T12K, L19I, K20I, L24*, E35D, I62V, L63P, I64V, I72V, V77I	B
	48-1121	1121-30728	DQ877412	PI	NA	M46L, L90M		L10R, T12P, K14KR, E35D, M36I, I62IV, L63P, I64V, I72V, V77I	B
	48-3087	3087-30331	DQ877996	PI	NA	M46L, I54V, V82A	L33F	L10R, K20R, E35D, M36I, N37D, L63P, A71V, V77VI, T91A, I93L	B
	48-3289	3289-30709	DQ878194	PI	NA	V32I, M46I, I47V, V82T, L90M		L10R, I15V, L19I, K20T, E35D, I62IV, L63P, A71I, I93L	B
	48-3374	3374-30711	DQ878232	PI	NA	M46I, I54V, V82T		L10R, K14R, I15V, K20T, E35D, N37D, I62V, L63P, H69HQ, A71V, T91AS, I93L	B
	48-7165	7165-30611	DQ879002	PI	NA	M46L, G48A, I54V, V82A		L10R, T12TP, K20R, E35D, M36I, N37ND, L63P, I64V, A71V, V77I, T91A, Q92QK, I93L	B
	48-9262	9262-30922	DQ877611	PI	NA	M46I, I47IV, I54V, L90M	G73T	L10R, I13M, K14R, L19I, K20I, E35D, M36I, I62V, L63P, I64V, I93L, C95F	B
Rosen-Zvi (2008)	25	00p25-1		NFV, IDV	140	M46L		L10R, D29A, K55R, L63P, I93L	B
Rhee (2009)	CA23800	CA55225	FJ983506	IDV, NFV, RTV, APV, LPV, ATV	262	V32I, M46I, I47V, I50L, V82T, L90M		L10R, N37H, R41K, L63P, A71I, I72V, V77I, I93L	B
		CA84293	FJ983508	IDV, NFV, RTV, APV, LPV, ATV	381	V32I, M46I, I47V, I50L, V82T, L90M		L10R, N37H, R41K, L63P, A71L, I72V, V75VI, V77I, I93L	B
Jones (2012)	152995	152995	JN669792	PI	NA	M46I, I54L, L90M		L10R, I13V, K20V, E35N, M36I, K55R, D60E, I62V, L63P, I64V	B
	156893	156893	JN669876	PI	NA	V32I, M46I, I47V, I54M, L90M	L33LF, G73S, L89V	L10R, E34EQ, K43R, Q61QH, L63P, A71IV, I72T, V77I, I93L	B
	157897	157897	JN669902	PI	NA	M46L, I54V, I84V, L90M	L33F, Q58E, T74P, L89V	T4TS, L10R, I13V, K14R, K20T, E35D, M36I, I62V, L63P, A71V, I72V, Q92K, I93L	B

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