<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype B
Gene PR
Mutation L10R
Rx >= 1 PI
IncludeMixtures No
References 19
Patients 45
Isolates 60
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Condra (1996)pt-AptAW12 IDV12M46I L10R, R57K, I64VB
  ptAW24 IDV24M46I, V82T, I84V L10R, T12A, R57K, L63P, I64VB
  ptAW40 IDV40M46I, V82T, I84VL24IL10R, T12I, N37D, L63P, A71VB
  ptAW52 IDV52M46I, I54V, V82TL24I, G73SL10R, K20I, R57K, L63P, A71VB
Gatanaga (1999)Gat-NR1agaNR1AB020916IDV, NFV72V82T L10R, I62V, L63P, A71T, V77I, I93LB
Zolopa (1999)CA632CA3136AF085106IDV60M46L, V82T, L90M I3X, L10R, L63P, A71V, V77I, I93LB
Bacheler (2000)LB3-P69P69-24 IDV22  L10R, E35D, R57K, L63P, K70RB
  P69-32 IDV30  L10R, E35D, R57K, L63P, K70RB
  P69-39 IDV37 L24IL10R, E35D, R57K, L63P, K70RB
 LB4-P145P145-43 IDV24M46L L10R, K14R, R41K, L63P, I64V, K70R, V77IB
  P145-55 IDV36M46L L10R, K14R, R41K, L63P, I64V, K70R, V77IB
 LB3-P20P20-24 IDV24M46L, V82T L10R, R57K, L63P, V77I, I93LB
  P20-27 IDV27M46L, V82T L10R, R57K, L63P, A71V, V77I, I93LB
  P20-58 IDV58M46L, V82T L10R, R57K, L63P, A71V, V77I, I93LB
  P20-70 IDV70M46L, V82T L10R, R57K, L63P, A71V, V77I, I93LB
Baxter (2000)GART-NG131GART-131 Unknown, IDVNAM46L, V82T L10R, N37T, L63P, V77I, I93LB
Falloon (2000)JF10JF10-(-)1wAF227703IDV, SQV68M46I, V82T, L90MG73SL10R, N37D, I62V, L63P, A71V, V77I, I93LB
  JF10-12wAF227704IDV, SQV, APV80M46I, V82T, L90MG73SL10R, N37D, I62V, L63P, A71V, V77I, I93LB
Rousseau (2000)MNR5MNR4062AJ405950IDV, SQV, RTV, NFV122M46I, I84V, L90MG73CL10R, Q18H, N37S, I62V, L63P, I64V, I66V, I72V, V77I, I93L, C95FB
Shulman (2000)CA632CA9441AY798356IDV, SQV, RTV119M46L, G48EV, I54IV, V82T, L90MF53FLL10R, G16A, L63P, A71V, I72IV, T74TS, V77I, I93LB
Gonzales (2001)CA1447CA3864AY030585IDV99M46I, V82T, L90M L10R, I13V, K14KR, L63P, I64V, A71AV, V77I, I93LB
 CA1544CA4416AY030661NFV, SQV, RTV64D30N, I84IV, L90MN88DL10R, T12P, K14R, L63P, A71T, I72T, V77I, I93LB
 CA2076CA7686AY030785IDV, NFV52M46L, L90M L10R, E35G, M36I, R57K, Q61E, I62V, L63P, E65D, A71V, I93LB
 CA5611CA13953AY032078IDV, NFV199  L10R, E35D, N37E, L63P, A71T, V77I, Q92KB
 CA5751CA14289AY032141IDV105M46I L10R, T12A, L63P, I64V, I72IV, I93LB
Kempf (2001)DK-5394DK-5394 IDV, NFV93M46L L10R, L63P, A71T, I72T, V77VI, I93ILB
 DK-5605DK-5605 IDV, NFV104M46MI, L90M L10R, L63P, I64V, V77I, I93LB
Monno (2003)ML_Pat70ML_Pat70 PINAM46L, L90M L10R, L63P, C67Y, H69K, A71V, I93MB
 ML_Pat83ML_Pat83 PINAV82T, I84V L10R, T12I, R41K, K55R, I62V, L63P, H69T, A71T, V77IB
Colonno (2004)RC-009-017-078017-07821 NFV, SQV, ATV28D30N, I54L, L90MN88DL10R, E35D, M36I, N37D, K45R, L63P, H69Q, A71V, I93LB
Gomez-Carrillo (2004)9890598905AY365589PINAM46I, L90MG73CL10R, T12K, I13V, L19I, K20I, E35D, I62V, L63P, I64V, I72V, V77IB
Garcia-Bujalance (2005)GBS_42GBS_42AY872323RTV, NFV, SQV, LPV I47V, G48M, I54L, V82A, I84V, L90ML33F, F53LP9S, L10R, K14N, I15K, E34Q, N37D, L63P, A71V, V77I, I93LB
Rhee (2005)CA632CA1204AY351708IDV, SQV, RTV84M46L, G48V, V82T, L90M L10R, L63P, A71V, T74TS, V77I, I93LB
 CA1543CA7985AY796766Unknown, SQV, NFV, IDV, RTV>90M46I, I84V, L90M L10R, L63P, I64V, V77I, I93LB
 CA2076CA41194AY796864IDV, NFV, SQV, RTV284M46L, I54L, I84V, L90M L10R, I13IV, K14E, L19V, K20T, E35G, M36I, R57K, Q61E, I62V, L63P, I64V, E65N, A71V, P79A, Q92K, I93LB
 CA7126CA17603AY797540IDV82M46I, L90M L10R, K20I, E35D, M36I, N37S, R57K, I62V, L63P, I64V, I72X, I93L, C95FB
  CA24237AY797541IDV112M46I, L90M L10R, I15IV, K20I, E35D, M36X, N37S, R57K, I62V, L63P, I64V, I93L, C95FB
 CA9684CA23695AY797803IDV, SQV, RTV276M46L, I84V, L90M L10R, I13V, N37S, D60DE, I62V, L63P, I64V, V77IB
 SWC-59445944-4336 IDV159M46I, I84V L10R, I13V, Q18QH, K20T, Q61E, I64V, I66F, H69R, V77IB
Baxter (2006)12-14211421-30331DQ876015PINAD30N, M46L, I54L, L90MV32V_W, N88DL10R, I15V, L19Q, K20T, R41K, K55KR, L63P, K70R, A71V, V77IB
 12-20772077-30609DQ876018PINAV32I, M46I, I47V, I54M, V82T, L90MV11IL10R, I13V, K20I, L33V, K55R, I62V, L63P, A71L, I72L, Q92RB
 12-14891489-30320DQ876042PINAM46I, I47V, I54V, V82T, L90M L10R, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I72V, I93LB
 12-40484048-30714DQ876154PINAM46L, L90MG73CL10R, I15V, L19P, K20I, E35G, M36L, N37T, P39S, K55R, Q61D, I62V, L63P, C67L, A71T, I72T, T74S, Q92KB
 12-10801080-30414DQ876420PINAM46LV, L76V, I84VV11VI, L89VL10R, T12P, I13V, L19M, K20I, E34EQ, E35D, M36I, K55R, R57K, D60E, I62V, L63P, A71I, T91A, I93LB
 12-17861786-30506DQ876684PINAV32I, M46I, I47V, I54M, V82T, L90ML89VL10R, I13V, L19T, K20M, E35E_E, M36I, L63P, A71IB
 12-30693069-30417DQ876733PINAM46I, I84V, L90ML33F, Q58EL10R, T12P, I13V, E35D, N37S, K55R, R57K, I62V, L63P, H69R, V82VI, T91S, C95FB
 12-32003200-30716DQ877186PINAM46I, I54V, V82T, L90MK43TL10R, L19I, K20R, E35D, M36I, K55R, R57K, L63P, A71V, V77I, Q92K, I93LB
 48-10831083-30708DQ877340PINAM46I, I54IT, L90MG73CL10R, T12K, L19I, K20I, L24*, E35D, I62V, L63P, I64V, I72V, V77IB
 48-11211121-30728DQ877412PINAM46L, L90M L10R, T12P, K14KR, E35D, M36I, I62IV, L63P, I64V, I72V, V77IB
 48-30873087-30331DQ877996PINAM46L, I54V, V82AL33FL10R, K20R, E35D, M36I, N37D, L63P, A71V, V77VI, T91A, I93LB
 48-32893289-30709DQ878194PINAV32I, M46I, I47V, V82T, L90M L10R, I15V, L19I, K20T, E35D, I62IV, L63P, A71I, I93LB
 48-33743374-30711DQ878232PINAM46I, I54V, V82T L10R, K14R, I15V, K20T, E35D, N37D, I62V, L63P, H69HQ, A71V, T91AS, I93LB
 48-71657165-30611DQ879002PINAM46L, G48A, I54V, V82A L10R, T12TP, K20R, E35D, M36I, N37ND, L63P, I64V, A71V, V77I, T91A, Q92QK, I93LB
 48-92629262-30922DQ877611PINAM46I, I47IV, I54V, L90MG73TL10R, I13M, K14R, L19I, K20I, E35D, M36I, I62V, L63P, I64V, I93L, C95FB
Rosen-Zvi (2008)2500p25-1 NFV, IDV140M46L L10R, D29A, K55R, L63P, I93LB
Rhee (2009)CA23800CA55225FJ983506IDV, NFV, RTV, APV, LPV, ATV262V32I, M46I, I47V, I50L, V82T, L90M L10R, N37H, R41K, L63P, A71I, I72V, V77I, I93LB
  CA84293FJ983508IDV, NFV, RTV, APV, LPV, ATV381V32I, M46I, I47V, I50L, V82T, L90M L10R, N37H, R41K, L63P, A71L, I72V, V75VI, V77I, I93LB
Jones (2012)152995152995JN669792PINAM46I, I54L, L90M L10R, I13V, K20V, E35N, M36I, K55R, D60E, I62V, L63P, I64VB
 156893156893JN669876PINAV32I, M46I, I47V, I54M, L90ML33LF, G73S, L89VL10R, E34EQ, K43R, Q61QH, L63P, A71IV, I72T, V77I, I93LB
 157897157897JN669902PINAM46L, I54V, I84V, L90ML33F, Q58E, T74P, L89VT4TS, L10R, I13V, K14R, K20T, E35D, M36I, I62V, L63P, A71V, I72V, Q92K, I93LB