<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation I93L
Rx >= 1 PI
IncludeMixtures No
References 18
Patients 68
Isolates 70
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG7070_w27 NFV27  I13V, G16E, E35D, M36I, R41K, L63V, G68GE, H69K, L89M, T91V, I93LA
Grossman (2004)IL88IL88AY529535NFV65  A22R, E35D, M36I, R41K, H69K, L89M, I93LA
 IL351IL351AY529589NFV226M46IQ58QEI13V, K14KR, K20KR, E35ED, M36I, N37ND, R41K, H69K, L89I, I93LA
Montes (2004)MB_patELA02_ELA701AJ577884SQV, RTV, Unknown>25  I13V, G16E, E35D, M36I, R41K, L63A, G68E, H69K, K70R, L89I, T91V, I93LA
 MB_patROI00_ROI705AJ577983SQV, RTV, IDV193  I13V, G16E, K20R, M36I, R41K, L63N, H69K, K70R, L89I, T91V, I93LA
Non-B Workgroup (2005)IL276IL276 IDV81  L10I, E35D, M36I, R41K, R57K, L63T, H69R, L89M, I93LA
 TK4003TK4003 NFV116 N83DL10V, I13V, K14R, G16E, E35D, M36I, R41K, K45R, R57K, L63T, H69K, K70R, L89M, I93LA
 TK4009TK4009 IDV336  I13V, K14R, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93LA
Weber (2005)F73291F73291AY677477NFV195M46LL33I, N83DL10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93LA
Baxter (2006)48-12021202-30702DQ877746PINAI54V, V82A, L90ML33F, N83DI13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93LA
 48-41864186-30408DQ878420PINAI54V, V82AL24I, L33I, Q58E, N83DL10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93LA
Saad (2006)MDS_02UAKV12502UAKV125DQ055293SQV   I13IV, G16GA, E35D, M36I, R41K, H69K, L89M, I93LA
Steegen (2009)BV114BV114-1EU872122LPV4  I13V, G16E, K20R, E35D, M36I, R41K, Q61H, L63T, G68E, H69K, K70R, V82I, L89M, T91V, I93LA
Thomson (2009)SP_B_029RU_SP_B_029FJ009794LPV, NFV25  K14R, E35D, M36I, R41K, H69K, L89M, I93LA
 SP_B_051RU_SP_B_051FJ009809DRV4  I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89M, I93LA
Hamkar (2010)30Ir-HIV-DR-30GU724833PINA  T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LA
Charpentier (2011)CR-50CR-50FJ688256PINAM46IL10FK20I, E35D, M36I, N37D, R41K, I62IV, L63T, H69K, T74A, V77VI, I85IV, L89M, I93LA
Dvali (2012)R126R126GQ268514NFV M46MI L10LI, I15IV, E35D, M36I, R41K, H69K, L89M, I93LA
 R005R005FJ456894NFV M46MI, N88NSL23LI, K43KTK14R, I15IV, K20T, E35D, M36I, N37D, R41K, L63P, H69K, A71AV, L89M, I93LA
Kouri (2012)CU2007-09CU2007-09JQ585330PINAM46I, I54V, V82A, I84VL24I, L33FL10I, T12S, G16A, L19I, K20V, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74S, L89M, I93LA
 CU1737-09CU1737-09JQ585309PINAM46MI, I54V, L76V, V82AL10F, L24I, L33FI13V, N37S, R41K, Q61QH, L63P, H69K, A71V, L89M, I93LA
 CU1124-09CU1124-09JQ585275PINAM46MI, I54V, L76V, V82AL10F, L24I, L33FI13V, N37S, R41K, L63P, H69K, A71V, L89M, I93LA
Avidor (2013)989_MT989_MTKC184397NFV L90ML10LFI13V, K20T, E35D, M36I, R41K, H69K, A71AV, T74S, L89I, I93LA
Van Zyl (2013)11791314KC423050LPV26  T12S, I13V, I15V, G16E, K20R, E35D, M36I, L63S, I64L, H69K, L89M, I93LA
 7211935KC423520LPV52  T12P, I13V, I15V, G16E, E35D, M36I, R41RK, D60DE, L63S, H69K, K70R, L89IM, T91V, I93LA
Grossman (2014)20882088KC184354LPV52  L10V, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93LA
 14601460KC184186LPV52  I13IV, E35D, M36I, R41K, Q61E, L63P, H69K, V77I, L89M, I93LA
 711711KF135126LPV52  I13IV, I15IV, G16GE, E35D, M36I, R41K, L63LP, H69K, I72V, L89M, I93LA
 5959KC213684NFV, LPV52 V11CFISW6RS, Q7D, R8T, L10LH, I13V, K20I, E35D, M36I, R41K, H69K, L89M, Q92L, I93L, T96HA
 288288KF135041NFV, LPV104  I13IV, E35D, M36I, R41K, L63LP, H69K, L89M, I93LA
 792792KC184392LPV52  I13V, E35D, M36I, R41K, H69K, T74S, L89M, I93LA
 14391439KC184185NFV, LPV52  K20KR, M36I, R41K, Q61QE, H69K, L89M, I93LA
 18631863 LPV52  L10I, I13V, K14R, E35D, M36I, N37D, R41K, D60E, Q61E, L63V, H69K, L89M, I93LA
 948948 LPV52  I13V, E35D, M36I, R41K, L63T, H69K, V77I, L89M, I93LA
 11291129 LPV52  I13V, I15V, K20R, M36I, N37ND, R41KN, L63LP, H69K, L89M, I93LA
Kolomeets (2014)331331_470KJ870546APV   E35D, M36I, R41K, H69K, V77VI, L89M, I93LA
 195195_344KJ870452LPV   L10I, K14R, G16E, E35D, M36I, R41K, Q61QE, L63LI, H69KQ, L89M, I93LA
 7676_88KJ870262LPV   L10LI, I13V, E35D, M36I, R41K, Q61E, L63T, E65D, H69K, T74S, L89M, I93LA
 312312_413KJ870505LPV   R8G, P9PL, K14R, G16A, E35D, M36I, N37D, R41K, H69K, V77VI, L89M, I93LA
 1111_139KJ870288LPV   I3V, G16E, E35D, H69K, K70R, V77I, L89M, I93LA
 297297_395KJ870495LPV   L10I, I13IV, K14R, G16E, E35D, M36I, R41K, L63LV, H69K, L89M, I93LA
 204204_246KJ870372LPV   I13IV, K14R, G16E, E35D, M36I, R41K, H69K, L89M, I93LA
 309309_408KJ870502LPV   L10V, E35D, M36I, R41K, H69K, L89M, I93LA
 205205_247KJ870373ATV   I13V, I15V, E35D, M36I, R41K, L63P, H69K, L89M, I93LA
 307307_405KJ870500APV  L33F, F53FLL10LI, K14R, G16E, K20R, E35D, M36I, R41K, H69K, L89M, I93LA
 1717_275KJ870396LPV M46I, I54IV E35D, M36I, R41K, L63I, H69K, V77I, L89M, I93LA
 111111_357KJ870464LPV   I13V, K14KR, I15V, G16GAV, T31TA, E35D, M36I, R41K, H69K, V77I, L89M, I93LA
 276276_507KJ870571APV   K14R, K20R, E35D, M36I, N37D, R41K, H69K, L89M, I93LA
 143143_311KJ870425LPV   I13V, K14R, G16GE, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
 150150_135KJ870284LPV   I13V, K14R, E35D, M36I, R41K, H69K, L89M, I93LA
 418418_662KJ870680LPV   I13IV, I15IV, K20KR, E35D, M36I, R41K, Q61QE, L63PS, H69K, V77VI, L89M, I93LA
 441441_636KJ870661LPV   I13V, K14R, E35D, M36I, R41K, H69K, L89M, I93LA
 410410_599KJ870631LPV   K14R, G16E, E35D, M36I, R41K, I62V, L63P, H69K, V77I, L89M, I93LA
 277277_508KJ870572LPV   E35D, M36I, R41K, Q61E, L63P, C67F, H69K, V77I, L89M, I93LA
 316316_419KJ870510APV  L33F, T74PI13V, K14R, E34EG, E35D, M36I, R41K, R57RK, D60DE, I62IT, L63LI, H69K, V77I, L89M, I93LA
 294294_558KJ870605SQV   K14KR, M36I, R41K, L63P, H69K, L89M, I93LA
 2323_268KJ870389LPV   K14R, G16E, E35D, M36I, R41K, H69K, L89M, I93LA
 1111_417KJ870509LPV   G16E, E35D, M36I, R41K, H69K, K70R, V77I, L89M, I93LA
 323323_458KJ870537ATV M46MIG48R, I54IFE35D, M36I, R41K, L63S, H69K, L89M, I93LA
 183183_329KJ870440LPV   G16E, E35D, M36I, R41K, D60E, Q61E, I62V, H69K, V77I, L89M, I93LA
 177177_276KJ870397LPV   I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89M, I93LA
 3333_461KJ870540APV I54IL L10I, I13V, K14R, G16E, E35D, M36MI, R41K, H69K, V77I, L89I, I93LA
 262262_233KJ870366LPV   I13V, I15V, M36I, R41K, L63P, H69K, L89IM, I93LA
 1717_134KJ870283LPV M46I E35D, M36I, R41K, L63I, H69K, V77I, L89M, I93LA
 280280_552KJ870603LPV   G16E, E35D, M36I, R41K, H69K, L89M, I93LA
 474474_650KJ870672LPV   I13V, E35D, M36I, R41K, L63LIPT, H69K, T74S, L89M, I93LA
Steegen (2014)10ZAKS05810ZAKS058KJ176340LPV M46I, I54V, V82A R41K, L63P, H69K, A71AV, I93LA
 12ZAKS19512ZAKS195KJ176476LPV M46I, I54V, L76V, V82A Q61QH, I62V, L63V, H69K, T74S, L89M, I93LA
 10ZAKS05210ZAKS052KJ176334LPV M46I, I54V, V82A R41K, L63P, H69K, A71AV, L89LM, I93LA
 09ZAKS00109ZAKS001KJ176285LPV M46I, I54V, L76V, V82A R41K, D60E, Q61E, L63P, H69K, L89M, I93LA