<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L89I
Rx PI-naive
IncludeMixtures No
References 51
Patients 77
Isolates 77
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Cornelissen (2000)MC93GH05MC93GH05AF212277None   I13V, G16E, K20R, E35D, M36I, N37D, G40X, R41K, L63V, G68E, H69K, K70R, L89I, T91V, I93LA
Masharsky (2003)A011698UA0116AF413987None   I13V, K14R, E35D, M36I, N37D, R41K, H69K, L89I, I93LA
Non-B Workgroup (2005)PL4985392544 None   L10V, I13V, G16E, E35D, M36I, R41K, K45R, L63Q, H69K, L89IA
Vazquez de Parga (2005)RU99011RU99011EU345784None  V11II13V, K14R, G16E, L24F, E35D, M36I, R41K, I64V, H69K, L89I, I93LA
Saad (2006)MDS_01UAOD10201UAOD102DQ055241None   I13V, K14R, E35D, M36I, R41K, Q61E, C67Y, H69K, L89I, I93LA
 MDS_01UAOD10301UAOD103DQ055242None   I13V, K14R, E35D, M36I, R41K, Q61E, C67Y, H69K, L89I, I93LA
Saad (2006)MDS_01AZ00301AZ003DQ328520None   I13V, K14R, E35D, M36I, P39S, R41K, H69K, L89I, I93LA
Zarandia (2006)MZ_03GEMZ01203GEMZ012DQ205271None   L19I, E35D, M36I, R41K, C67Y, H69K, L89I, I93LA
Nyombi (2008)TMS121TMS121EU251821None   G16E, E35D, M36I, R41K, K45R, L63S, H69K, L89IA
Auwanit (2009)42AE-PR42FJ463518None   K14R, I15IV, L19LQ, E35D, M36I, R41K, I62V, L63ST, H69K, K70R, V82I, L89IA
Eshleman (2009)J12604W208-101518FJ389114None   I13V, E35D, M36I, R41K, H69K, L89IA
Vidal (2009)KMST91KMST91FM877784None  V11II13A, A22V, E35D, M36L, R41K, K45R, R57K, L63P, H69K, L89IA
Balode (2010)S2132S2132GU945139None   E35D, M36I, R41K, H69K, V77I, L89I, I93LA
 S2304S2304GU945174None   I13V, K14R, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
Carr (2010)1445MV01CM.1445MVGU201516None   I13V, G16E, E35D, M36I, R41K, K43R, L63V, G68E, H69K, K70R, L89I, T91V, I93LA
Vinogradova (2010)Dag38Dag38GQ867619None   I13V, E35D, M36I, R41K, H69K, L89I, I93LA
Charpentier (2011)232CP0011420 None   L10M, I13V, M36I, R41K, K43KR, H69K, L89IA
Hamers (2011)CP076301534CP076301534HQ993578None   I15V, G16E, L19X, E35D, M36I, R41K, R57K, L63H, H69K, I72V, L89IA
 CP076301681CP076301681HQ993677None   I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57K, Q61H, L63V, G68E, H69K, K70R, L89I, T91V, I93LA
 CP076301724CP076301724HQ993717None   I13V, K20R, M36I, R41K, R57K, H69K, L89IA
 CP076304140CP076304140HQ993876None   L10I, I13V, G16A, M36I, R41K, K43R, R57K, L63T, H69KN, K70R, V82I, L89IA
 CP076304158CP076304158HQ993883None   K14R, I15V, G16A, R41K, L63V, C67G, G68E, H69K, K70R, V77I, L89I, T91V, I93LA
 CP076304222CP076304222HQ993917None   I13V, G16E, E35ED, M36I, R41K, L63ST, H69K, L89I, T91VA
 CP076300767CP076300767HQ994938None   I13V, I15V, G16E, K20R, M36I, R41K, R57K, L63S, E65ED, H69K, L89IA
 CP076301920CP076301920HQ995392None   I13V, E35D, M36I, R41K, R57K, L63P, I64M, H69K, L89IA
 CP076301950CP076301950HQ995415None   I13V, E35D, M36I, R41K, R57K, L63P, I64M, H69K, L89IA
De Gascun (2012)IRL01320IRL01320JN622284None   I15IL, K20R, E35D, M36I, N37D, R41K, H69K, K70KR, L89I, L97L*A
Dvali (2012)R057R057GQ268461None   I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
 R132R132FJ539180None   L10LI, I13V, K14R, E35D, M36I, R41K, K45KR, Q61QE, H69K, L89I, I93LA
 R086R086GQ268483None   T4TS, I13V, K14R, Q18QH, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
Ndase (2012)5014982250149822KC900548None   I13V, G16E, E35D, M36I, R41RK, R57RK, L63C, H69K, K70KR, L89IA
 5606397256063972KC900796None   T12P, I13V, E35D, M36I, R41Q, R57K, D60E, L63P, H69K, L89IA
Sigaloff (2012)KECGP010KECGP010JN628462None   T12P, I13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89I, F99LA
Ssemwanga (2012)RCC_TDR-482974RCC_TDR-482974JQ266085None   L10I, I13V, M36L, R41K, H69Q, L89IA
Antoniadou (2013)GR137GR137KF671845None   I13V, E35D, M36I, R41K, K45R, R57K, L63F, H69K, I72V, V77VI, L89IA
Avidor (2013)19501950KC184285None   L10LI, I15V, K20R, E35D, M36I, R41K, H69K, L89I, I93LA
 20362036KC184346None   L10LI, I13V, G16GE, L23R, E35D, M36I, R41K, L63T, H69K, L89I, I93LA
 20082008KC184335None   P9PAS, I13IV, G16E, K20KR, E35D, M36I, R41K, L63FV, H69K, K70KR, L89I, I93LA
 15501550KC184195None   E34D, E35D, M36I, N37D, R41K, K45R, H69K, L89I, I93LA
Frentz (2013)EHR-78067EHR-78067JX300886None   I13V, K14R, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
Grgic (2013)cro500cro500HE653307None   I13V, K14R, E35D, M36I, R41K, H69K, L89I, I93LA
Hassan (2013)RS09000939RS09000939HQ441681None   I13V, G16E, E35D, M36I, R41K, Q61K, I62V, L63N, H69K, K70KR, I72E, L89I, T91VA
 RS11000292RS11000292JQ698379None   T12P, I13V, G16E, K20R, E35D, M36I, R41K, Q61H, L63N, C67CY, G68E, H69K, K70R, I72V, L89IA
Kiptoo (2013)KTL207KTL207KC517030None  L33LII13V, K20R, M36I, R41K, I62IV, L63AV, H69K, I72IT, L89I, T91VA
Telan (2013)1111785211117852AB747500None   K20R, M36I, R41K, L63P, H69K, L89I, I93LA
Bartolo (2014)09AOHDP24409AOHDP244KF853820None   I13V, I15V, K20R, M36I, R41K, H69K, K70KR, I72IM, L89IA
 09AOHDP10009AOHDP100KF853752None   L10I, I13V, E35D, M36I, R41K, H69K, L89IA
Hassan (2014)RS11000411RS11_411KC568509None   L10V, I13V, G16E, E35D, M36I, R41K, L63T, H69K, K70R, L89IA
Kolomeets (2014)160160_189KJ870330None   L10V, I13V, K14R, E35D, M36I, R41K, H69K, K70R, T74S, L89IA
 155155_184KJ870325None   I13V, K14R, G16E, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
 428428_582KJ870623None   E35D, M36I, N37D, R41K, H69K, L89IA
Meixenberger (2014)11-0235411-02354KJ771541None  V11VIL10V, T12TA, I13V, K14GR, G16E, K20R, E35D, M36I, R41K, R57K, L63T, H69K, K70R, L89IA
Cheriro (2015)NLHG-72NLHG-72KT370898None   I13V, K20KR, M36I, R41K, H69K, L89IA
Dauwe (2015)A2_04020A2_04020KT863616None  V11VII13V, G16E, E35D, M36I, R41K, L63A, H69K, K70R, L89I, T91VA
Hora (2015)DEMA108RU004DEMA108RU004KF716492None   I13V, M36I, R41K, H69K, L89I, I93LA
Kotaki (2015)UA15UA15KJ865339None  L33FI13V, K20R, M36I, P39S, R41K, I62V, L63P, G68E, H69K, K70R, L89IA
Moskaleychik (2015)MSK_SK_002MSK_SK_002KY238321None   I13V, M36I, R41K, H69K, L89I, I93LA
Billings (2016)KE556528V2KE556528V2KT022389None   E35D, M36I, R41K, R57K, H69K, K70R, L89IA
Castley (2016)P129379046P129379046KT228890None   I13V, K14R, L19I, E35D, M36I, R41K, R57K, H69K, L89I, F99XA
Chow (2016)MYNBB050MYNBB050KU535931None   L10V, T12I, I13V, M36I, R41K, L63P, H69K, K70R, V82I, L89IA
 MYNBB072MYNBB072KU535953None   T12I, I13V, M36I, N37D, R41K, L63P, H69K, K70R, V82I, L89I, I93LA
 MYNBB058MYNBB058KU535939None   T12I, I13V, E35D, M36I, N37D, R41K, L63P, H69K, K70R, V82I, L89I, I93LA
 MYNBB091MYNBB091KU535967None   T12I, I13V, E35D, M36I, N37D, R41K, L63P, H69K, V82I, L89IA
Fokam (2016)CIRCB-60AHCIRCB-60AHKR229802None   I13V, K14KR, K20KR, M36I, N37ND, R41RK, R57K, D60E, I62IV, L63P, H69K, L89IA
Gashnikova (2016)Tyumen09Tyumen09KX640125None   I13V, K14R, G16A, E35D, M36I, N37D, R41K, K45R, H69K, I72M, L89I, I93LA
Hattori (2016)C11_111201C11-51111201-1AB865607None   I13V, K14R, E35D, M36I, N37D, R41K, R57K, H69K, L89IA
Ndahimana (2016)11991199KU922824None   L10I, I13V, G16E, E35D, M36I, R41K, R57K, L63T, H69K, K70R, L89IA
Onsongo (2016)6464KM376182None   L33V, M36I, R41K, K45R, R57K, L63P, G68E, H69K, K70R, L89IA
 5656KM376177None  L33IM36I, R41K, L63A, H69K, L89IA
 5454KM376175None  L33IM36I, R41K, L63A, H69K, L89IA
Otecko (2016)404431404431KX306395None   I13V, K14R, E35D, M36I, R41K, R57RK, L63LP, H69K, L89IA
 402844402844KX306391None   I13V, K14R, G17E, M36I, R41K, K45R, H69K, L89IA
Pouran Yousef (2016)443211-02354KX467040None  V11VIL10V, T12TA, I13V, K14GR, G16E, K20R, E35D, M36I, R41K, R57K, L63T, H69K, K70R, L89IA
Reynolds (2016)J080118R15J080118R15KX944681None   T12A, I13V, E35D, M36I, R41K, K45R, H69K, K70R, L89IA
Zeh (2016)3002620_053002620_05KU248706None   E35D, M36I, R41K, K43R, L63T, H69K, L89I, T91VA
Zhao (2016)LS5566LS5566KT379637None   I13V, G16E, K20R, M36I, I62V, L63S, H69K, K70R, V82I, L89IA
Onywera (2017)05006030500603KX790964None  V11II13V, G16E, E35D, M36I, R41K, R57K, L63H, H69K, K70R, L89IA