<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L89I
Rx PI-naive
IncludeMixtures No
References 32
Patients 47
Isolates 47
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Eshleman (2002)123793k123793kAF410210None   I13V, G16E, E35D, M36I, R41K, R57K, L63H, H69K, I72V, L89IA
Masharsky (2003)A011698UA0116AF413987None   I13V, K14R, E35D, M36I, N37D, R41K, H69K, L89I, I93LA
Zhong (2003)ZP_Pat300CM1423AY371705None   L10I, T12A, I13V, I15V, Q18K, L19I, M36I, N37D, R41K, C67Y, H69K, I72M, L89IA
Non-B Workgroup (2005)PL4985392544 None   L10V, I13V, G16E, E35D, M36I, R41K, K45R, L63Q, H69K, L89IA
Vazquez de Parga (2005)RU99011RU99011EU345784None  V11II13V, K14R, G16E, L24F, E35D, M36I, R41K, I64V, H69K, L89I, I93LA
Saad (2006)MDS_01UAOD10201UAOD102DQ055241None   I13V, K14R, E35D, M36I, R41K, Q61E, C67Y, H69K, L89I, I93LA
 MDS_01UAOD10301UAOD103DQ055242None   I13V, K14R, E35D, M36I, R41K, Q61E, C67Y, H69K, L89I, I93LA
Saad (2006)MDS_01AZ00301AZ003DQ328520None   I13V, K14R, E35D, M36I, P39S, R41K, H69K, L89I, I93LA
Zarandia (2006)MZ_03GEMZ01203GEMZ012DQ205271None   L19I, E35D, M36I, R41K, C67Y, H69K, L89I, I93LA
von Wyl (2007)70492471EF450026None   I13V, M36L, N37S, R41K, I64IV, H69K, L89IA
Nyombi (2008)TMS121TMS121EU251821None   G16E, E35D, M36I, R41K, K45R, L63S, H69K, L89IA
Bartolo (2009)SNS3901AOSNS39EU068300None  V11IL10I, T12R, I13V, I15V, L19I, M36I, N37D, R41K, H69Q, V82I, L89IA
Eshleman (2009)J12604W208-101518FJ389114None   I13V, E35D, M36I, R41K, H69K, L89IA
Balode (2010)S2132S2132GU945139None   E35D, M36I, R41K, H69K, V77I, L89I, I93LA
 S2304S2304GU945174None   I13V, K14R, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
Carr (2010)1445MV01CM.1445MVGU201516None   I13V, G16E, E35D, M36I, R41K, K43R, L63V, G68E, H69K, K70R, L89I, T91V, I93LA
Vinogradova (2010)Dag38Dag38GQ867619None   I13V, E35D, M36I, R41K, H69K, L89I, I93LA
Yang (2010)20106934412010693441JQ616881None   I13V, G16E, L19V, K20I, E35D, M36I, R41K, H69K, K70R, V77I, L89IA
Charpentier (2011)232CP 001 1420 None   L10M, I13V, M36I, R41K, K43KR, H69K, L89IA
Hamers (2011)CP076301534CP076301534HQ993578None   I15V, G16E, L19X, E35D, M36I, R41K, R57K, L63H, H69K, I72V, L89IA
 CP076301681CP076301681HQ993677None   I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57K, Q61H, L63V, G68E, H69K, K70R, L89I, T91V, I93LA
 CP076301724CP076301724HQ993717None   I13V, K20R, M36I, R41K, R57K, H69K, L89IA
 CP076304140CP076304140HQ993876None   L10I, I13V, G16A, M36I, R41K, K43R, R57K, L63T, H69KN, K70R, V82I, L89IA
 CP076304222CP076304222HQ993917None   I13V, G16E, E35ED, M36I, R41K, L63ST, H69K, L89I, T91VA
 CP076300767CP076300767HQ994938None   I13V, I15V, G16E, K20R, M36I, R41K, R57K, L63S, E65ED, H69K, L89IA
 CP076301950CP076301950HQ995415None   I13V, E35D, M36I, R41K, R57K, L63P, I64M, H69K, L89IA
Kasang (2011)3265732657HM572367None   T12P, I13V, K14R, G16E, E35D, M36I, R41K, W42W*, L63S, H69K, G86GE, L89IA
De Gascun (2012)IRL01320IRL01320JN622284None   I15IL, K20R, E35D, M36I, N37D, R41K, H69K, K70KR, L89I, L97L*A
Dvali (2012)R057R057GQ268461None   I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
 R132R132FJ539180None   L10LI, I13V, K14R, E35D, M36I, R41K, K45KR, Q61QE, H69K, L89I, I93LA
 R086R086GQ268483None   T4TS, I13V, K14R, Q18QH, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
Sigaloff (2012)KECGP010KECGP010JN628462None   T12P, I13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89IA
 KELKN241KELKN241JN628507None   I13V, R41K, L63A, H69K, V82I, L89IA
Ssemwanga (2012)RCC_TDR-482974RCC_TDR-482974JQ266085None   L10I, I13V, M36L, R41K, H69Q, L89IA
Youngpairoj (2012)cm1657cm1657DQ166429None   T12I, I13V, G16E, K20I, E35N, M36I, N37D, R41K, L63H, H69K, I72E, L89IA
Antoniadou (2013)GR137GR137KF671845None   I13V, E35D, M36I, R41K, K45R, R57K, L63F, H69K, I72V, V77VI, L89IA
Avidor (2013)19501950KC184285None   L10LI, I15V, K20R, E35D, M36I, R41K, H69K, L89I, I93LA
 20362036KC184346None   L10LI, I13V, G16GE, L23R, E35D, M36I, R41K, L63T, H69K, L89I, I93LA
 20082008KC184335None   P9PAS, I13IV, G16E, K20KR, E35D, M36I, R41K, L63FV, H69K, K70KR, L89I, I93LA
 15501550KC184195None   E34D, E35D, M36I, N37D, R41K, K45R, H69K, L89I, I93LA
Frentz (2013)EHR-78067EHR-78067JX300886None   I13V, K14R, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
Hassan (2013)RS09000939RS09000939HQ441681None   I13V, G16E, E35D, M36I, R41K, Q61K, I62V, L63N, H69K, K70KR, I72E, L89I, T91VA
 RS11000292RS11000292JQ698379None   T12P, I13V, G16E, K20R, E35D, M36I, R41K, Q61H, L63N, C67CY, G68E, H69K, K70R, I72V, L89IA
Kiertiburanakul (2013)R74184R74184KC791403None   L10I, I13V, I15V, K20I, E35ED, M36I, R41K, C67S, H69K, K70R, V82I, L89IA
Kiptoo (2013)KTL207KTL207KC517030None  L33LII13V, K20R, M36I, R41K, I62IV, L63AV, H69K, I72IT, L89I, T91VA
Pircher (2013)A1018A1018JX110267None  V11II3V, L10M, T12S, I13V, L19I, E21EK, M36I, R41K, H69K, L89IA
Bartolo (2014)09AOHDP24409AOHDP244KF853820None   I13V, I15V, K20R, M36I, R41K, H69K, K70KR, I72IM, L89IA