Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	L89I
Rx	>= 1 PI
IncludeMixtures	No

References	9
Patients	24
Isolates	25

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Yahi (2001)	NY_M29	M29	AY010392	IDV		M46I, I54V, V82F		L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89I	A
Grossman (2004)	IL351	IL351	AY529589	NFV	226	M46I	Q58QE	I13V, K14KR, K20KR, E35ED, M36I, N37ND, R41K, H69K, L89I, I93L	A
Montes (2004)	MB_patELA	02_ELA701	AJ577884	SQV, RTV, Unknown	>25			I13V, G16E, E35D, M36I, R41K, L63A, G68E, H69K, K70R, L89I, T91V, I93L	A
	MB_patMUZ	00_MUZ714	AJ577959	NFV	18		L10F	I13V, E35D, M36I, R41K, R57K, H69K, L89I	A
	MB_patROI	00_ROI705	AJ577983	SQV, RTV, IDV	193			I13V, G16E, K20R, M36I, R41K, L63N, H69K, K70R, L89I, T91V, I93L	A
Non-B Workgroup (2005)	UK1436	UK1436	AY900801	SQV, RTV, NFV	123		N83D	I13V, K14R, K20R, A22V, E35D, M36I, R41K, R57K, H69K, L89I, T91A	A
	UK2088	UK2088		RTV		V82F		I13V, K14R, I15V, K20R, E35D, M36I, R41K, I62V, L63LP, H69K, T74TS, L89I, L97LS	A
	UK2149	UK2149	AY900859	Unknown, LPV	NA	M46I, L76V, I84V	L33I, N83D	L10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89I	A
	TK1001	TK1001a		IDV	179	V82A		L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89I	A
	TK2012	TK2012		RTV, IDV, SQV	186	I54V, L90M		L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89I	A
	TK3029	TK3029		SQV, NFV	149	L90M		L10V, I13V, K20T, E35D, M36I, R41K, H69K, T74S, L89I	A
	TK3030	TK3030a		SQV, NFV	312	I54IL, L90LM		I13V, K20RT, E35D, M36I, N37NT, R41K, K45KR, R57K, H69K, A71AV, L89I, I93IM	A
	TK4003	TK4003a		NFV	215	I54V	L33I, N83D	L10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89I	A
	TK4006	TK4006		NFV	83	N88S	L10F	I13V, I15V, K20I, E35N, M36I, R41K, K45R, R57Q, H69K, L89I	A
	TK5002	TK5002		NFV	189	N88S	L10F	I13V, K14R, I15V, K20T, E35D, M36I, R41K, K45R, R57K, H69K, L89I	A
	TK5005	TK5005		SQV, IDV, RTV, NFV, LPV	180	G48V, I54T, V82A, L90M		L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89I	A
		TK5005a		SQV, IDV, RTV, NFV, LPV	196	G48V, I54T, L90M		L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IM	A
Weber (2005)	F73291	F73291	AY677477	NFV	195	M46L	L33I, N83D	L10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93L	A
Baxter (2006)	48-1202	1202-30702	DQ877746	PI	NA	I54V, V82A, L90M	L33F, N83D	I13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93L	A
	48-3045	3045-30317	DQ877957	PI	NA	G48V, I54S, V82A	L33F, Q58E, N83D	L10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TS	A
	48-4153	4153-30326	DQ878387	PI	NA	M46I, I54L, L76V, I84V	L10F	I13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TS	A
	48-8053	8053-30818	DQ879078	PI	NA	M46L, G48V, I54S, V82A	L33I, F53L	L10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89I	A
von Wyl (2007)	70	496347	EF449835	PI	NA		N83D	I13V, M36L, N37T, R41K, H69K, L89I	A
Koyalta (2009)	17	TCHAD-17	FJ688177	IDV	26	M46I, I84V		L10I, I13V, K14R, I15V, K20I, M36I, R41K, R57K, L63P, I66F, H69N, I72V, L89I	A
Jones (2012)	159797	159797	JN669961	PI	NA	M46I, I54V, L76V, V82A	L33LF	L10I, I13V, I15IV, G16E, K20M, E35D, M36I, R41K, K55R, R57K, Q61N, A71T, I72R, L89I	A

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