<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L89I
Rx >= 1 PI
IncludeMixtures No
References 14
Patients 40
Isolates 42
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M29M29AY010392IDV M46I, I54V, V82F L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89IA
Grossman (2004)IL351IL351AY529589NFV226M46IQ58QEI13V, K14KR, K20KR, E35ED, M36I, N37ND, R41K, H69K, L89I, I93LA
Montes (2004)MB_patELA02_ELA701AJ577884SQV, RTV, Unknown>25  I13V, G16E, E35D, M36I, R41K, L63A, G68E, H69K, K70R, L89I, T91V, I93LA
 MB_patMUZ00_MUZ714AJ577959NFV18 L10FI13V, E35D, M36I, R41K, R57K, H69K, L89IA
 MB_patROI00_ROI705AJ577983SQV, RTV, IDV193  I13V, G16E, K20R, M36I, R41K, L63N, H69K, K70R, L89I, T91V, I93LA
Non-B Workgroup (2005)UK1436UK1436AY900801SQV, RTV, NFV123 N83DI13V, K14R, K20R, A22V, E35D, M36I, R41K, R57K, H69K, L89I, T91AA
 UK2088UK2088 RTV V82F I13V, K14R, I15V, K20R, E35D, M36I, R41K, I62V, L63LP, H69K, T74TS, L89I, L97LSA
 UK2149UK2149AY900859Unknown, LPVNAM46I, L76V, I84VL33I, N83DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89IA
 TK1001TK1001a IDV179V82A L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89IA
 TK2012TK2012 RTV, IDV, SQV186I54V, L90M L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89IA
 TK3029TK3029 SQV, NFV149L90M L10V, I13V, K20T, E35D, M36I, R41K, H69K, T74S, L89IA
 TK3030TK3030a SQV, NFV312I54IL, L90LM I13V, K20RT, E35D, M36I, N37NT, R41K, K45KR, R57K, H69K, A71AV, L89I, I93IMA
 TK4003TK4003a NFV215I54VL33I, N83DL10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89IA
 TK4006TK4006 NFV83N88SL10FI13V, I15V, K20I, E35N, M36I, R41K, K45R, R57Q, H69K, L89IA
 TK5002TK5002 NFV189N88SL10FI13V, K14R, I15V, K20T, E35D, M36I, R41K, K45R, R57K, H69K, L89IA
 TK5005TK5005 SQV, IDV, RTV, NFV, LPV180G48V, I54T, V82A, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89IA
  TK5005a SQV, IDV, RTV, NFV, LPV196G48V, I54T, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IMA
Weber (2005)F73291F73291AY677477NFV195M46LL33I, N83DL10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93LA
Baxter (2006)48-12021202-30702DQ877746PINAI54V, V82A, L90ML33F, N83DI13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93LA
 48-30453045-30317DQ877957PINAG48V, I54S, V82AL33F, Q58E, N83DL10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TSA
 48-41534153-30326DQ878387PINAM46I, I54L, L76V, I84VL10FI13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TSA
 48-80538053-30818DQ879078PINAM46L, G48V, I54S, V82AL33I, F53LL10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89IA
von Wyl (2007)70496347EF449835PINA N83DI13V, M36L, N37T, R41K, H69K, L89IA
Koyalta (2009)17TCHAD-17FJ688177IDV26M46I, I84V L10I, I13V, K14R, I15V, K20I, M36I, R41K, R57K, L63P, I66F, H69N, I72V, L89IA
Jones (2012)159797159797JN669961PINAM46I, I54V, L76V, V82AL33LFL10I, I13V, I15IV, G16E, K20M, E35D, M36I, R41K, K55R, R57K, Q61N, A71T, I72R, L89IA
Kouri (2012)CU376-10CU376-10JQ585390PINAG48V, I54V, V82A L10V, T12I, I13V, K20I, E35D, M36I, N37DE, R41K, H69K, T74S, L89IA
Avidor (2013)989_MT989_MTKC184397NFV L90ML10LFI13V, K20T, E35D, M36I, R41K, H69K, A71AV, T74S, L89I, I93LA
Kolomeets (2014)143143_311KJ870425LPV   I13V, K14R, G16GE, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
 3333_328KJ870439APV   L10LI, I13V, K14KR, G16E, E35D, M36MI, R41K, H69K, V77I, L89IA
  33_461KJ870540APV I54IL L10I, I13V, K14R, G16E, E35D, M36MI, R41K, H69K, V77I, L89I, I93LA
Steegen (2014)09ZAKS00309ZAKS003KJ176287LPV M46I, I54V, L76V, V82AQ58QER41K, D60E, I62V, L63P, H69K, L89IA
Diaz (2015)RenG16883RenG16883KT747911PINAM46IV32A, L33F, F53L, T74TPL10V, I13V, I15V, K20R, E35D, M36I, R41K, R57K, Y59YH, Q61DN, I66F, L89IA
 RenG16869RenG16869KT747897PINAM46L, I54V, V82A, L90ML33IL10V, T12K, I13V, K20R, E35D, M36I, R41K, F53I, K55N, R57K, D60E, Q61N, I62V, L63S, A71T, L89I, Q92KA
 RenG16257RenG16257KT747285PINAM46I, I54V, L76V, V82AL24IL10I, I13V, K20M, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63P, A71T, I72T, T74S, L89IA
 RenG15167RenG15167KT746195PINAG48M, I54V, V82A, L90MK43T, F53LL10IV, V11L, T12P, I13V, K20I, E35D, M36I, N37K, R41K, R57K, Q61N, L63P, T74S, L89I, Q92KA
 RenG14159RenG14159KT745187PINAI54L, V82AL33F, K43KPQT, N83DL10V, I13V, K14R, G16A, K20R, E35D, M36I, N37NDGS, R41K, L63V, H69K, K70R, L89IA
 RenG15076RenG15076KT746104PINAM46I, V82FF53L, N83DW6V, L10V, I13A, A22V, E35D, M36I, R41K, K43R, R57K, Q61N, I62V, L63P, H69R, T74S, L89I, I93LA
 RenG13889RenG13889KT744917PINAG48V, I54T, V82AK43KTL10I, T12S, I13V, K20M, E35D, M36I, R41K, R57K, Q61N, T74S, L89I, N98K, F99FLA
 RenG11829RenG11829KT742857PINAM46I, I47A, I84V, L90MF53LL10Y, I13V, I15V, K20IT, E35DG, M36I, R41K, R57K, Q61N, L63P, A71V, T74S, L89I, I93LA
 RenG12114RenG12114KT743142PINAM46L, I54V, V82A, L90ML33I, Q58E, N83DL10IV, I13V, K14R, K20R, E35D, M36I, N37X, R41K, K55R, R57K, D60E, I62V, L63P, A71T, L89I, T91SA
 RenG11397RenG11397KT742425PINAM46I, I47V, I54L, V82AL33I, K43T, N83DK20KR, A22V, E35D, M36I, N37D, R57K, D60E, Q61E, I72T, L89IA
 RenG10032RenG10032KT741060PINAM46I, I54V, V82A, N88S, L90ML10F, L33F, Q58EI13V, G16E, K20T, E35D, M36I, P39PQ, R41K, R57K, Q61N, I62V, L63H, A71T, I72V, V77I, L89IA