<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation I84V
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 20
Isolates 23
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M72M72AY010434IDV M46MI, I84V I13V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89TA
Vergne (2003)VL00SN69HPD00SN69AJ583752IDV I84VG73SI13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, A71V, L89TA
Montes (2004)MB_patSAN01_SANC718AJ577992SQV, IDV, RTV143M46I, I84V, L90MG73S, L89VL10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69KA
 MB_patMAK01_MAK707AJ577938SQV, RTV, NFV182I54V, I84V, L90MV32G, F53LL10I, I13V, K14R, G17E, K20I, E35D, M36I, R41K, L63P, H69K, T74A, L89MA
  01_MAK719AJ577939SQV, RTV, NFV, LPV203M46I, I54V, I84VF53LL10V, I13V, K14R, G17E, K20I, E35D, M36I, R41K, H69K, T74A, L89MA
  02_MAK737AJ577940SQV, RTV, NFV, LPV225M46I, I47V, I54V, I84VF53LL10I, I13V, K14R, G17E, K20I, E35D, M36I, N37E, R41K, H69K, T74A, L89MA
Non-B Workgroup (2005)UK2149UK2149AY900859Unknown, LPVNAM46I, L76V, I84VL33I, N83DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89IA
 PL3403155128 IDV, NFV207M46I, I84VL89VL10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71VA
Baxter (2006)48-32643264-30703DQ878168PINAM46I, I54V, I84V, L90ML10F, L89VI13V, K14KR, G16E, K20L, M36I, D60E, Q61H, L63R, I66V, H69K, K70R, A71T, P79A, I93L, C95FA
  3264-40322DQ878169PI, RTV, TPV>38M46I, I54V, I84V, L90ML10F, L89VI13V, G16E, K20L, L23M, M36I, D60E, Q61H, L63R, I66V, H69K, K70R, A71T, P79A, I93L, C95VA
 48-33333333-30929DQ878227PINAM46I, I47V, I54V, I84VL33F, G73SL10V, I13V, I15V, K20T, E35D, M36I, P39S, R41K, Q61D, I62V, L63P, I66F, H69K, T74S, L89TA
 48-41534153-30326DQ878387PINAM46I, I54L, L76V, I84VL10FI13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TSA
Rosen-Zvi (2008)4600p46-1 RTV, SQV, NFV, APV141M46MIL, I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89IA
Knops (2010)ID1585ID1585-GT1GU271168SQV, NFV, RTV, APV I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89IA
Barber (2012)5085750857JQ361664LPV M46I, L76V, I84V L10I, I13V, G16E, M36I, R41K, L63T, H69K, L89MA
Kouri (2012)CU108-10CU108-10JQ585364PINAV32I, I54L, I84VL33F, K43T, F53LL10I, I13V, I15S, L19LI, K20R, E35D, M36I, R41K, D60E, Q61E, I62V, L63T, I64IV, H69K, A71AV, T74A, P79A, L89MA
 CU544-09CU544-09JQ585255PINAM46I, I47V, I54V, I84V, L90ML10F, V11VI, L33I, Q58E, G73S, T74P, N88G, L89VI13AV, K14R, K20IT, E35N, M36I, N37D, R41K, I62V, L63V, H69K, K70RA
Avidor (2013)196196 APV M46I, I84VL10FI, L33FI13V, K20R, L24LV, E35D, M36I, N37D, R41K, K45R, R57K, I62IV, H69K, L89M, I93VA
Kim (2013)Tx22307KC120891IDV, ATV V32I, M46I, I47V, I84VL33LF, F53L, L89VL10Y, T12V, I13V, G16E, K20M, E35D, M36I, N37ND, R41K, R57K, H69K, A71I, I72RA
Nerrienet (2014)U0407179U0407179JN675767LPV M46I, I84V, L90ML10F, L33F, F53L, Q58E, G73GS, N88G, L89VI13V, K20T, E35D, M36I, R41K, K55R, R57K, L63P, I66IF, H69K, A71VA
 R1113090R1113090JN675748LPV M46I, I47V, L76V, I84VL10FI13V, G16Q, L19V, K20I, E35D, M36I, P39S, R41K, K55R, D60E, I66F, H69K, A71AV, L89MA
Ndahimana Jd Riedel (2016)21412141KT982484LPV M46I, I54V, L76V, I84V L10I, I13A, K14R, I15V, K20I, E35N, M36I, R41K, K45R, K55R, R57K, I66F, H69K, L89I, I93VA
 21332133KT982485LPV M46I, I54V, V82A, I84VL10FI13V, G16E, K20R, E35D, M36I, N37E, R41K, K45I, R57K, Q61N, L63H, H69K, K70R, I72IT, L89MA