Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	N83D
Rx	>= 1 PI
IncludeMixtures	No

References	5
Patients	14
Isolates	15

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Gibb (2002)	DMG106	106_w41		NFV	41	M46L	N83D	I13V, G16A, K20R, A22V, E35D, M36I, R41K, R57K, I64IV, H69K, L89M	A
Non-B Workgroup (2005)	UK1436	UK1436	AY900801	SQV, RTV, NFV	123		N83D	I13V, K14R, K20R, A22V, E35D, M36I, R41K, R57K, H69K, L89I, T91A	A
	UK2149	UK2149	AY900859	Unknown, LPV	NA	M46I, L76V, I84V	L33I, N83D	L10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89I	A
	PL9728	60099	AY901076	IDV, RTV, ATV		I54V, V82A	L33I, F53L, N83D	L10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91A	A
	TK2002	TK2002		IDV, RTV	273	M46MI, V82AT	L33I, N83D	L10LI, I13V, K14R, A22AV, E35D, M36I, R41K, R57K, H69K, L89IM	A
	TK4003	TK4003		NFV	116		N83D	L10V, I13V, K14R, G16E, E35D, M36I, R41K, K45R, R57K, L63T, H69K, K70R, L89M, I93L	A
		TK4003a		NFV	215	I54V	L33I, N83D	L10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89I	A
Weber (2005)	F73291	F73291	AY677477	NFV	195	M46L	L33I, N83D	L10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93L	A
Baxter (2006)	12-2024	2024-30709	DQ876698	PI	NA	M46L, I54V	L33F, N83D	L10V, I13V, K14R, E35D, M36IL, N37ND, R41K, R57K, H69Q, L89M	A
	48-1202	1202-30702	DQ877746	PI	NA	I54V, V82A, L90M	L33F, N83D	I13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93L	A
	48-1204	1204-30709	DQ877748	PI	NA	M46I, G48Q, I54T, V82F	L33F, Q58E, N83D	L10V, I13V, G16E, E35D, M36L, P39S, R57K, I62V, L63V, H69K, T74A, L89M	A
	48-1254	1254-30617	DQ877779	PI	NA	G48V	L33F, N83D	L10LI, I13V, E35D, M36V, N37NS, P39T, R41K, R57K, L63S, H69K, L89M	A
	48-3045	3045-30317	DQ877957	PI	NA	G48V, I54S, V82A	L33F, Q58E, N83D	L10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TS	A
	48-4186	4186-30408	DQ878420	PI	NA	I54V, V82A	L24I, L33I, Q58E, N83D	L10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93L	A
von Wyl (2007)	70	496347	EF449835	PI	NA		N83D	I13V, M36L, N37T, R41K, H69K, L89I	A

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