Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	V82A
Rx	>= 1 PI
IncludeMixtures	No

References	6
Patients	15
Isolates	15

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Weidle (2001)	PW_UG4399	PW_UG4399a		RTV	69	V82A	L33F	L10V, I13V, K20R, E35D, M36I, R41K, R57K, C67Y, H69K, L89M	A
Non-B Workgroup (2005)	PL9728	60099	AY901076	IDV, RTV, ATV		I54V, V82A	L33I, F53L, N83D	L10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91A	A
	TK1001	TK1001a		IDV	179	V82A		L10I, I13V, K14R, E35D, M36I, R41K, R57K, H69K, L89I	A
	TK5005	TK5005		SQV, IDV, RTV, NFV, LPV	180	G48V, I54T, V82A, L90M		L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89I	A
Weber (2005)	M41971	M41971	AY677401	IDV, NFV, LPV	181	I54V, V82A	L10F, L33I	T4TS, I13V, G16E, L19LI, K20R, E35D, M36I, N37D, R41K, K45V, K55T, R57K, L63H, H69K, K70R, L89M, T91TS	A
Baxter (2006)	48-1202	1202-30702	DQ877746	PI	NA	I54V, V82A, L90M	L33F, N83D	I13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93L	A
	48-3045	3045-30317	DQ877957	PI	NA	G48V, I54S, V82A	L33F, Q58E, N83D	L10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TS	A
	48-4186	4186-30408	DQ878420	PI	NA	I54V, V82A	L24I, L33I, Q58E, N83D	L10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93L	A
	48-5010	5010-30820	DQ878543	PI	NA	M46MIL, I54V, V82A	Q58E	L10I, I13V, K20KR, E35D, M36I, N37ND, R41K, I62V, L63P, A71T	A
	48-5031	5031-30421	DQ878557	PI	NA	M46I, I54V, V82A	G73S	I13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89T	A
	48-8053	8053-30818	DQ879078	PI	NA	M46L, G48V, I54S, V82A	L33I, F53L	L10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89I	A
Laurent (2006)	CK22-35	03CM2-35	AM279456	IDV	74	I54IV, V82A	L33LI	L10I, I13V, E35D, M36I, R41K, K45R, L63P, H69K, L89T	A
Jones (2012)	159797	159797	JN669961	PI	NA	M46I, I54V, L76V, V82A	L33LF	L10I, I13V, I15IV, G16E, K20M, E35D, M36I, R41K, K55R, R57K, Q61N, A71T, I72R, L89I	A
	184144	184144	JN670673	PI	NA	M46I, I50IL, I54AV, V82A	L24I, L33F, Q58E	L10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89M	A
	199883	199883	JN671186	PI	NA	M46I, I54V, V82A, L90M	N88D	L10I, I13V, I15V, L19I, K20I, E35D, M36I, N37K, R41K, K45R, K55R, R57K, Q61N, L63P, C67F, A71T, I72E	A

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