<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation V77I
Rx >= 1 PI
IncludeMixtures No
References 8
Patients 43
Isolates 48
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Weber (2003)SIIRIS6I-48AY140815SQV, RTV52  I13V, E35D, M36I, R41K, R57K, H69K, V77I, L89MA
Non-B Workgroup (2005)TK2017TK2017 NFV35  I13V, E35D, M36I, R41K, R57K, H69K, V77I, L89MA
 TK2029TK2029 IDV39  L10I, I13V, K14R, G16GE, E35D, M36I, R41K, K45R, R57K, L63P, H69K, V77I, L89MA
Baxter (2006)48-33163316-30818DQ878217PINAI54A, V82F L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89MA
Thomson (2009)SP_B_005RU_SP_B_005FJ009783RTV, IDV, APV, LPV   K14R, G16GE, E35D, M36I, R41K, H69K, V77I, L89M, I93ILA
 SP_B_051RU_SP_B_051FJ009809DRV4  I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89M, I93LA
Reynolds (2012)J7227J0722-2JN652210LPV   I13V, K20I, A22AV, E35N, M36I, R41K, H69K, V77I, L89MA
Avidor (2013)1756_FN1756_FNKC184227LPV   I13IV, E35D, M36I, N37ND, R41K, H69K, V77I, L89MA
Grossman (2014)14601460KC184186LPV52  I13IV, E35D, M36I, R41K, Q61E, L63P, H69K, V77I, L89M, I93LA
 948948 LPV52  I13V, E35D, M36I, R41K, L63T, H69K, V77I, L89M, I93LA
Kolomeets (2014)430430_630KJ870658LPV   I13V, K14R, E21EK, E35D, M36I, R41K, H69K, V77I, R87RK, L89MA
 1111_139KJ870288LPV   I3V, G16E, E35D, H69K, K70R, V77I, L89M, I93LA
 162162_192KJ870333LPV   I13V, E35D, M36I, R41K, L63P, H69K, V77I, L89MA
 442442_639KJ870664LPV   L10I, I13V, K14R, G16E, E35D, M36I, N37D, R41K, H69K, V77I, L89MA
 3737_591KJ870627LPV   L10IV, I13V, I15V, K20KI, E34EK, E35DN, M36I, N37D, R41K, K55KR, H69K, V77I, L89MA
 175175_272KJ870393PINAM46LL10FI13V, M36I, R41K, H69K, T74S, V77I, L89MA
 313313_414KJ870506LPV   L10I, I13V, K14R, G16E, E35D, M36I, R41K, H69K, V77I, L89MA
 423423_577KJ870619ATV   E35D, M36I, R41K, L63S, H69K, V77I, L89MA
 273273_442KJ870527LPV   L10I, I13V, K14KR, G16E, E35EDKN, M36I, R41K, I62V, H69K, T74S, V77I, L89MA
 1717_275KJ870396LPV M46I, I54IV E35D, M36I, R41K, L63I, H69K, V77I, L89M, I93LA
 2727_332KJ870443ATV M46MI I15IV, G16GA, E35D, M36I, R41K, Q58P, D60DE, Q61QE, H69K, V77I, L89MA
 104104_288KJ870406LPV   I13IV, K14KR, G16GE, E35D, M36I, R41K, L63LP, H69K, V77I, L89MA
 111111_357KJ870464LPV   I13V, K14KR, I15V, G16GAV, T31TA, E35D, M36I, R41K, H69K, V77I, L89M, I93LA
 143143_311KJ870425LPV   I13V, K14R, G16GE, E35D, M36I, R41K, H69K, V77I, L89I, I93LA
 196196_346KJ870454LPV   I13V, E35D, M36I, R41K, R57RK, I66N, H69K, V77I, L89MA
 265265_230KJ870364PINA  I13V, E35D, M36I, R41K, H69K, V77I, L89MA
 343343_521KJ870581LPV   I13V, K14R, G16E, K20I, E35DN, M36I, N37NDY, R41K, H69K, K70KR, V77I, L89MA
 399399_565KJ870611PINA  I13V, K14KR, E35D, M36I, R41K, H69K, V77I, L89MA
 3333_328KJ870439APV   L10LI, I13V, K14KR, G16E, E35D, M36MI, R41K, H69K, V77I, L89IA
 410410_599KJ870631LPV   K14R, G16E, E35D, M36I, R41K, I62V, L63P, H69K, V77I, L89M, I93LA
 3737_529KJ870586LPV   L10I, I13V, I15IV, E35D, M36I, N37D, R41K, H69K, V77I, L89MA
 298298_396KJ870496LPV   I13IV, E35D, M36I, R41K, H69K, V77I, L89MA
 277277_508KJ870572LPV   E35D, M36I, R41K, Q61E, L63P, C67F, H69K, V77I, L89M, I93LA
 2525_415KJ870507LPV   I13V, K14KR, G16GE, L19I, K20I, E35D, M36I, R41K, H69K, V77I, L89MA
 4545_625KJ870655NFV   R41K, R57RK, L63P, I64L, H69K, V77I, L89MA
 2525_137KJ870286LPV   I13V, K14KR, L19LI, K20KI, E35D, M36I, R41K, H69K, V77I, L89MA
 189189_338KJ870448LPV   I3V, L10LI, I13V, I15IV, E35D, M36I, R41K, I62IV, H69K, V77I, L89MA
 340340_517KJ870578ATV   I13IV, K14R, G16GA, E35D, M36I, R41K, R57K, L63P, H69K, V77I, L89MA
 316316_419KJ870510APV  L33F, T74PI13V, K14R, E34EG, E35D, M36I, R41K, R57RK, D60DE, I62IT, L63LI, H69K, V77I, L89M, I93LA
 191191_340KJ870450LPV   I13V, E35D, M36I, R41K, H69K, V77I, L89MA
 283283_436KJ870523LPV   E35ED, M36IK, R41K, H69K, V77I, L89MA
 1111_417KJ870509LPV   G16E, E35D, M36I, R41K, H69K, K70R, V77I, L89M, I93LA
 183183_329KJ870440LPV   G16E, E35D, M36I, R41K, D60E, Q61E, I62V, H69K, V77I, L89M, I93LA
 177177_276KJ870397LPV   I13V, I15V, E35D, M36I, R41K, H69K, V77I, L89M, I93LA
 3333_461KJ870540APV I54IL L10I, I13V, K14R, G16E, E35D, M36MI, R41K, H69K, V77I, L89I, I93LA
 1717_134KJ870283LPV M46I E35D, M36I, R41K, L63I, H69K, V77I, L89M, I93LA
 193193_342KJ870451APV I47IVL33F, F53LI13V, I15V, K20T, E35D, M36I, R41K, H69K, V77I, L89MA
 314314_416KJ870508LPV   L10LI, T12S, I13V, K14KR, E35D, M36I, R41K, H69K, V77I, L89MA