<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation T74S
Rx PI-naive
IncludeMixtures No
References 28
Patients 50
Isolates 50
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Nkengasong (2000)JN_IC275JN_IC275AF216986None   I13A, K20I, M36I, N37D, R41K, R57K, I64V, H69K, T74S, L89MA
Vergne (2002)LV01BLV01BAJ313403None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, H69K, T74S, L89MA
Eshleman (2004)SE164SE164pAY435390None   I13V, E35D, M36I, R41K, R57K, L63V, H69K, I72V, T74S, L89MA
Snoeck (2004)BE26BE26AY900733None   I13V, K20I, E35D, M36I, N37D, R41K, R57K, H69K, T74S, L89MA
Holguin (2005)2764-0000_2764-00AY248327None   L10I, I13V, M36I, R41K, L63V, H69K, T74S, L89MA
Non-B Workgroup (2005)IL353IL353AY900817None   I13V, E35D, M36I, R57K, D60AE, I62V, L63P, H69K, T74S, L89MA
 UK4956UK4956AY901211None   I13V, K14R, G17E, E35D, M36I, R41K, K45R, R57K, I62V, L63P, H69K, K70R, T74S, L89MA
 TK1023TK1023 None   L10LI, I13V, K14R, K20R, E21ED, E35D, M36I, N37D, R41K, R57K, I62V, H69K, T74S, L89MA
Tee (2005)03MYKLZai03_ZaiAY904539None   I13V, E35D, H69K, T74S, L89MA
Baker (2007)300NG01-300NGAY803462None   I13V, K14R, K20I, E35D, M36I, R41K, H69K, T74S, L89MA
Gatanaga (2007)C04-5555-5799-1C04-5555-5799-1AB640397None   I13V, K20I, E35D, M36I, R41K, I62IV, H69K, T74S, L89MA
 C04-5555-5800-1C04-5555-5800-1AB640398None   I13V, K20I, E35D, M36I, R41K, H69K, T74S, L89M, I93LA
Nyombi (2008)TBK037TBK037EU251736None   I13V, E35D, M36I, R41K, R57K, Q61E, I62V, L63C, I64V, H69K, T74S, L89MA
 TMS148TMS148EU251837None   I13V, G16E, E35D, M36I, R41K, Q61H, L63H, H69K, I72V, T74S, L89M, I93LA
Avi (2009)U37U37FJ154010None   I13V, K14R, E35D, M36I, R41K, I62V, H69K, T74S, L89MA
Kousiappa (2009)CY178CY178EU673409None   I13V, K14N, E35D, M36I, R57K, L63T, H69K, I72T, T74S, L89M, I93IL, F99FLA
Vercauteren (2009)pt11396327463877GQ399885None   I13V, E35D, M36I, R57K, I62IV, L63PS, H69K, T74S, L89M, L97L*, N98NIA
 pt10217094410226GQ400003None   L10LI, I13V, G16GE, E35D, M36I, R41K, R57K, I62V, L63IT, H69K, T74S, L89MA
 pt7288779959813GQ400296None   I13V, E35D, M36I, R41K, R57K, I62V, L63T, H69K, T74S, L89MA
Djoko (2010)635CD2047FR666635None   E35D, M36I, R41K, Q61E, I62V, L63V, E65D, H69K, I72V, T74S, V77I, L89MA
Ndembi (2010)DT2794_05_P12794GQ409609None   I13V, E35D, M36I, R41K, R57K, I62V, L63V, I64M, H69K, T74S, L89MA
Charpentier (2011)179CP 001 1982 None   G16A, E35D, M36L, R41K, I62V, H69K, T74S, L89MA
El Annaz (2011)1573715737HQ393321None   T12S, I13V, K14I, I15V, L19Q, K20R, E34EG, M36I, N37NHRS, L63T, H69K, T74S, L89M, I93LA
Hamers (2011)CP076301543CP076301543HQ993586None   I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, T74S, L89MA
 CP076301595CP076301595HQ993633None   L10I, I13V, E35D, M36I, N37D, R41K, R57K, I62V, C67Y, H69K, K70R, T74S, L89MA
 CP076301676CP076301676HQ993672None   I13V, K20R, E35D, M36I, N37D, R41K, K45R, R57RK, I62IV, H69K, T74S, L89MA
 CP076302262CP076302262HQ993769None   L10I, I13V, K20R, E35D, M36I, R41H, R57K, I62V, L63V, I64L, H69K, T74S, L89MA
 CP076301637CP076301637HQ993783None   I13V, E35D, M36I, R41K, I62V, H69K, T74S, L89MA
 CP076301868CP076301868HQ995003None   I13V, K14R, I15V, E35D, M36I, R41K, Q61E, I62V, H69K, T74S, L89MA
 CP076302055CP076302055HQ995022None   I13V, K14R, K20I, E35D, M36I, R41K, L63T, H69K, T74S, L89MA
 CP076303001CP076303001HQ995069None   I13A, K14E, K20L, M36I, R41K, H69K, T74S, L89MA
 CP076303065CP076303065HQ995245None   I13V, K20KR, E35D, M36I, R41K, R57RK, I62V, L63T, H69K, T74S, V75I, L89MA
Ndembi (2011)NTCPS701NTCPS701HQ702669None   I13V, K14R, E35D, M36I, R41K, R57K, I62V, L63S, H69K, T74S, L89MA
De Gascun (2012)IRL10565IRL10565JN622281None   L10I, I13IM, E35D, M36I, R41K, R57K, I62V, L63T, E65D, H69K, T74S, L89MA
 IRL14463IRL14463JN622290None   I13V, K20KR, E35D, M36I, R41K, R57RK, I62V, L63T, H69K, T74S, R87RI, L89MA
Dvali (2012)R088R088GQ268485None   I13V, K14R, E35D, M36I, R41K, H69K, T74S, V77I, L89M, I93LA
 R016R016GQ268427None   L10V, I13V, K14R, G16E, E35D, M36I, R41K, H69K, T74S, L89M, I93LA
Karlsson (2012)SE_185SE_185JQ698793None   I13V, K14S, K20I, E35D, M36I, R57K, L63T, I64L, H69K, I72T, T74S, L89MA
Sigaloff (2012)KELKN216KELKN216JN628489None   L10V, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89MA
 KELKN261KELKN261JN628520None   L10V, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89MA
Antoniadou (2013)GR083GR083KF671797None   L10I, I13V, I15V, G16E, L19V, K20I, E35D, M36I, P39PLS, R57K, L63AT, E65ED, H69K, T74S, L89M, T91TIA
Frentz (2013)EHR-11577EHR-11577JX299726None   I13V, E35D, M36I, R57K, I62V, L63A, H69K, I72V, T74S, L89MA
 EHR-13657EHR-13657JX299764None   I13V, K14R, G17E, K20I, L33V, E35N, M36I, R41K, D60E, L63P, H69K, T74S, L89MA
 EHR-18756EHR-18756JX299849None   I13V, E35D, M36I, R57K, I62V, L63P, H69K, T74S, L89MA
 EHR-51234EHR-51234JX300393None   I13V, K14KR, E35D, M36I, R41K, I62IV, L63T, H69K, T74S, V77I, L89M, I93LA
Kiptoo (2013)KTL217KTL217KC517033None   I13V, K20R, E35D, M36I, N37D, R41K, R57K, D60DE, I62IV, H69K, I72V, T74S, L89MA
 SNH021SNH021KC516938None   I13V, K14R, E35D, M36I, R41K, R57K, L63T, H69K, T74S, L89MA
 KTL125KTL125KC517035None   I13V, K14RT, L19Q, K20R, M36I, R41K, R57K, I62IV, L63LI, I64IV, H69KR, T74S, L89MA
Pircher (2013)A1020A1020JX110268None   K14R, L19I, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89MA
Van Zyl (2013)14541849KC423457None   T12P, I13V, L19I, E35D, M36I, R41K, K45R, I62V, L63G, H69K, T74S, L89MA