<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation T74S
Rx PI-naive
IncludeMixtures No
References 37
Patients 82
Isolates 82
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Eshleman (2004)SE164SE164pAY435390None   I13V, E35D, M36I, R41K, R57K, L63V, H69K, I72V, T74S, L89MA
Holguin (2005)2764-0000_2764-00AY248327None   L10I, I13V, M36I, R41K, L63V, H69K, T74S, L89MA
Non-B Workgroup (2005)IL353IL353AY900817None   I13V, E35D, M36I, R57K, D60AE, I62V, L63P, H69K, T74S, L89MA
 UK4956UK4956AY901211None   I13V, K14R, G17E, E35D, M36I, R41K, K45R, R57K, I62V, L63P, H69K, K70R, T74S, L89MA
 TK1023TK1023 None   L10LI, I13V, K14R, K20R, E21ED, E35D, M36I, N37D, R41K, R57K, I62V, H69K, T74S, L89MA
Baker (2007)300NG01-300NGAY803462None   I13V, K14R, K20I, E35D, M36I, R41K, H69K, T74S, L89MA
Galluzzo (2007)M22260UG_M22260JQ220067None   I15V, E35D, M36I, R41K, L63V, H69K, T74SA
Gatanaga (2007)C04-5555-5799-1C04-5555-5799-1AB640397None   I13V, K20I, E35D, M36I, R41K, I62IV, H69K, T74S, L89MA
 C04-5555-5800-1C04-5555-5800-1AB640398None   I13V, K20I, E35D, M36I, R41K, H69K, T74S, L89M, I93LA
Nyombi (2008)TBK037TBK037EU251736None   I13V, E35D, M36I, R41K, R57K, Q61E, I62V, L63C, I64V, H69K, T74S, L89MA
 TMS148TMS148EU251837None   I13V, G16E, E35D, M36I, R41K, Q61H, L63H, H69K, I72V, T74S, L89M, I93LA
Avi (2009)U37U37FJ154010None   I13V, K14R, E35D, M36I, R41K, I62V, H69K, T74S, L89MA
Kousiappa (2009)CY178CY178EU673409None   I13V, K14N, E35D, M36I, R57K, L63T, H69K, I72T, T74S, L89M, I93IL, F99FLA
Vercauteren (2009)pt11396327463877GQ399885None   I13V, E35D, M36I, R57K, I62IV, L63PS, H69K, T74S, L89M, L97L*, N98NIA
 pt10217094410226GQ400003None   L10LI, I13V, G16GE, E35D, M36I, R41K, R57K, I62V, L63IT, H69K, T74S, L89MA
 pt7288779959813GQ400296None   I13V, E35D, M36I, R41K, R57K, I62V, L63T, H69K, T74S, L89MA
Djoko (2010)635CD2047FR666635None   E35D, M36I, R41K, Q61E, I62V, L63V, E65D, H69K, I72V, T74S, V77I, L89MA
Ndembi (2010)DT2794_05_P12794GQ409609None   I13V, E35D, M36I, R41K, R57K, I62V, L63V, I64M, H69K, T74S, L89MA
Charpentier (2011)179CP0011982 None   G16A, E35D, M36L, R41K, I62V, H69K, T74S, L89MA
Hamers (2011)CP076301543CP076301543HQ993586None   I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, T74S, L89MA
 CP076301595CP076301595HQ993633None   L10I, I13V, E35D, M36I, N37D, R41K, R57K, I62V, C67Y, H69K, K70R, T74S, L89MA
 CP076301676CP076301676HQ993672None   I13V, K20R, E35D, M36I, N37D, R41K, K45R, R57RK, I62IV, H69K, T74S, L89MA
 CP076302262CP076302262HQ993769None   L10I, I13V, K20R, E35D, M36I, R41H, R57K, I62V, L63V, I64L, H69K, T74S, L89MA
 CP076301637CP076301637HQ993783None   I13V, E35D, M36I, R41K, I62V, H69K, T74S, L89MA
 CP076301868CP076301868HQ995003None   I13V, K14R, I15V, E35D, M36I, R41K, Q61E, I62V, H69K, T74S, L89MA
 CP076302055CP076302055HQ995022None   I13V, K14R, K20I, E35D, M36I, R41K, L63T, H69K, T74S, L89MA
 CP076303001CP076303001HQ995069None   I13A, K14E, K20L, M36I, R41K, H69K, T74S, L89MA
 CP076303065CP076303065HQ995245None   I13V, K20KR, E35D, M36I, R41K, R57RK, I62V, L63T, H69K, T74S, V75I, L89MA
Ndembi (2011)NTCPS701NTCPS701HQ702669None   I13V, K14R, E35D, M36I, R41K, R57K, I62V, L63S, H69K, T74S, L89MA
Sigaloff (2011)HIV100871HIV100871JN132252None   I13V, L19I, E35D, M36I, R41K, R57K, I62V, L63V, I64M, H69K, T74S, L89MA
De Gascun (2012)IRL10565IRL10565JN622281None   L10I, I13IM, E35D, M36I, R41K, R57K, I62V, L63T, E65D, H69K, T74S, L89MA
Dvali (2012)R152R152GQ268526None   I13V, E35D, M36I, R41K, Q61E, H69K, T74S, L89M, I93LA
 R088R088GQ268485None   I13V, K14R, E35D, M36I, R41K, H69K, T74S, V77I, L89M, I93LA
 R016R016GQ268427None   L10V, I13V, K14R, G16E, E35D, M36I, R41K, H69K, T74S, L89M, I93LA
Karlsson (2012)SE_185SE_185JQ698793None   I13V, K14S, K20I, E35D, M36I, R57K, L63T, I64L, H69K, I72T, T74S, L89MA
Nazziwa (2012)51376305137630JX499010None   I13V, K20I, E35D, M36I, N37S, R41K, R57K, H69K, T74S, L89MA
Sigaloff (2012)KECGP051KECGP051JN628467None  L33IL10I, I13V, K20R, M36I, R41K, R57K, I62V, L63C, I66L, H69K, T74S, L89MA
 KELKN216KELKN216JN628489None   L10V, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89MA
 KELKN225KELKN225JN628497None   G16E, K20R, E35D, M36I, P39S, R41K, R57K, I62V, H69K, T74S, L89MA
 KELKN261KELKN261JN628520None   L10V, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89MA
Antoniadou (2013)GR083GR083KF671797None   L10I, I13V, I15V, G16E, L19V, K20I, E35D, M36I, P39PLS, R57K, L63AT, E65ED, H69K, T74S, L89M, T91TIA
Avidor (2013)1612_MN1612_MNKC184212None   T12P, I13V, E35D, M36I, R57K, I62V, L63P, H69K, T74S, L89MA
 1913_MT1913_MTKC184253None   I13V, E35D, M36I, R57K, I62V, L63AT, E65D, H69K, T74S, L89MA
 20062006KC184333None  M46MTE35D, M36I, R57K, I62V, L63AT, E65D, H69K, T74S, L89MA
 19121912KC184252None   T12TA, I13V, K14KR, I15IV, E35D, M36I, R57K, I62V, L63ST, H69K, I72V, T74S, L89MA
 16031603KC184208None   L10I, I13V, L19I, K20KI, E35D, M36I, R57K, D60E, I62V, L63P, H69K, T74S, L89MA
 20912091KC184357None   I13V, E35D, M36I, R57K, I62V, E65D, H69K, T74S, L89MA
 19701970KC184303None   I13V, E35D, M36I, R57K, I62V, L63S, H69K, I72V, T74S, L89MA
 20092009KC184336None   I13V, I15IV, E35D, M36I, R41K, H69K, T74S, L89M, I93LA
 353353KC184368None   I13V, E35D, M36I, R57K, D60AE, I62V, L63P, H69K, T74S, L89MA
 20262026KC184344None   I13V, E35D, M36I, R57K, D60E, I62V, L63P, H69K, T74S, L89MA
Frentz (2013)EHR-11577EHR-11577JX299726None   I13V, E35D, M36I, R57K, I62V, L63A, H69K, I72V, T74S, L89MA
 EHR-13657EHR-13657JX299764None   I13V, K14R, G17E, K20I, L33V, E35N, M36I, R41K, D60E, L63P, H69K, T74S, L89MA
 EHR-18756EHR-18756JX299849None   I13V, E35D, M36I, R57K, I62V, L63P, H69K, T74S, L89MA
 EHR-51234EHR-51234JX300393None   I13V, K14KR, E35D, M36I, R41K, I62IV, L63T, H69K, T74S, V77I, L89M, I93LA
Kiptoo (2013)KTL217KTL217KC517033None   I13V, K20R, E35D, M36I, N37D, R41K, R57K, D60DE, I62IV, H69K, I72V, T74S, L89MA
Pircher (2013)A1020A1020JX110268None   K14R, L19I, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89MA
Aghokeng (2014)TG-1-035TG-1-035KC350294None   I3L, L10I, I13V, E35D, R41K, L63P, H69K, T74S, V77I, L89MA
Chung (2014)KEW32_RT_160eKEW32_RT_160eKF544228None   E35D, M36I, R41K, I62V, H69K, T74S, V77VI, L89MA
 KTF_34_KA249eKTF_34_KA249eKF544249None   E35D, M36I, R41K, R57K, I62V, L63T, H69K, T74S, L89MA
Kolomeets (2014)250250_316KJ870429None   I13V, M36I, R41K, H69K, T74S, L89M, I93LA
 345345_524KJ870583None   L10I, I13V, K14R, E35D, M36I, N37D, R41K, H69K, T74S, L89MA
 160160_189KJ870330None   L10V, I13V, K14R, E35D, M36I, R41K, H69K, K70R, T74S, L89IA
 254254_162KJ870306None   I13V, E35D, M36I, R41K, L63T, H69K, T74S, V77I, L89M, I93LA
 286286_532KJ870588None   L10V, I13V, I15V, L19I, M36I, L63P, H69K, T74S, V77I, L89MA
Lee (2014)AMU080AMU080KJ906696None   T12TA, I13V, I15IV, G16GE, L19LI, E35D, M36I, R41K, R57K, L63IMV, H69K, K70KR, I72IV, T74S, L89MA
Budambula (2015)MK106MK106KP792100None   L10V, I13V, K14R, K20R, E35D, M36I, R41K, R57K, I62V, L63T, I64M, H69K, T74S, L89MA
 MK80MK80KP792074None   L10V, I13V, K14R, E35D, M36I, R57K, I62V, L63T, H69K, T74S, L89MA
 MK110MK110KP792104None   L10V, I13V, K14R, K20R, E35D, M36I, R41K, R57K, I62V, L63T, I64M, H69K, T74S, L89MA
Billings (2016)KE484390V7KE484390V7KT022414None   I13V, E35D, M36I, N37D, R57K, L63T, H69K, T74S, V77I, L89MA
Castley (2016)R030136222R030136222KT229184None   I13V, G16E, E35D, M36I, R41K, R57RK, L63E, H69K, K70R, T74S, L89M, T91VA
Gashnikova (2016)Tyumen05Tyumen05KX640121None   I13V, M36I, R41K, H69K, T74S, L89M, I93LA
 Tyumen39Tyumen39KX640150None   I13V, K14R, E35D, M36I, R41K, H69K, T74S, V77I, L89M, I93LA
 Tyumen23Tyumen23KX640135None   I13V, K20KI, E35D, M36I, R41K, H69K, T74S, V77I, L89M, I93LA
 Tyumen06Tyumen06KX640122None   T12A, I13V, I15V, L19I, E35D, M36I, R41K, I62V, H69K, T74S, V77I, L89MA
 Tyumen74Tyumen74KX640179None   I13V, E35D, M36I, R41K, H69K, T74S, V77I, R87RK, L89M, I93LA
 Tyumen01Tyumen01KX640117None   I13V, E35D, M36I, R41K, I62V, L63V, C67F, H69K, T74S, V77I, L89IM, I93LA
 Tyumen40Tyumen40KX640151None   I13V, E35D, M36I, R41K, H69K, K70R, T74S, L89M, I93LA
Hoenigl (2016)V0861855V0861855KU574453None   L10LI, I13V, K14KR, G16GE, M36I, N37E, R41K, R57K, H69K, T74S, L89MA
 V0874882V0874882KU574462None   I13V, K14R, M36I, N37E, R41K, R57K, H69K, T74S, L89MA
Onsongo (2016)1717KM376158None   E35D, M36I, R41K, R57K, I62V, L63V, H69K, T74S, V77I, L89MA
Otecko (2016)423541423541KX306472None   I13V, G16E, K20KR, E35D, M36I, R41K, L63V, H69K, T74S, L89M, T91V, I93LA