Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	T74S
Rx	PI-naive
IncludeMixtures	No

References	23
Patients	42
Isolates	42

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	OtherMut	Subtype
Nkengasong (2000)	JN_IC275	JN_IC275	AF216986	None	I13A, K20I, M36I, N37D, R41K, R57K, I64V, H69K, T74S, L89M	A
Vergne (2002)	LV01B	LV01B	AJ313403	None	L10V, I13V, I15V, E35D, M36I, R41K, K45R, H69K, T74S, L89M	A
Eshleman (2004)	SE164	SE164p	AY435390	None	I13V, E35D, M36I, R41K, R57K, L63V, H69K, I72V, T74S, L89M	A
Snoeck (2004)	BE26	BE26	AY900733	None	I13V, K20I, E35D, M36I, N37D, R41K, R57K, H69K, T74S, L89M	A
Holguin (2005)	2764-00	00_2764-00	AY248327	None	L10I, I13V, M36I, R41K, L63V, H69K, T74S, L89M	A
Non-B Workgroup (2005)	IL353	IL353	AY900817	None	I13V, E35D, M36I, R57K, D60AE, I62V, L63P, H69K, T74S, L89M	A
	UK4956	UK4956	AY901211	None	I13V, K14R, G17E, E35D, M36I, R41K, K45R, R57K, I62V, L63P, H69K, K70R, T74S, L89M	A
	TK1023	TK1023		None	L10LI, I13V, K14R, K20R, E21ED, E35D, M36I, N37D, R41K, R57K, I62V, H69K, T74S, L89M	A
Tee (2005)	03MYKLZai	03_Zai	AY904539	None	I13V, E35D, H69K, T74S, L89M	A
Baker (2007)	300NG	01-300NG	AY803462	None	I13V, K14R, K20I, E35D, M36I, R41K, H69K, T74S, L89M	A
Gatanaga (2007)	C04-5555-5799-1	C04-5555-5799-1	AB640397	None	I13V, K20I, E35D, M36I, R41K, I62IV, H69K, T74S, L89M	A
	C04-5555-5800-1	C04-5555-5800-1	AB640398	None	I13V, K20I, E35D, M36I, R41K, H69K, T74S, L89M, I93L	A
Nyombi (2008)	TBK037	TBK037	EU251736	None	I13V, E35D, M36I, R41K, R57K, Q61E, I62V, L63C, I64V, H69K, T74S, L89M	A
	TMS148	TMS148	EU251837	None	I13V, G16E, E35D, M36I, R41K, Q61H, L63H, H69K, I72V, T74S, L89M, I93L	A
Avi (2009)	U37	U37	FJ154010	None	I13V, K14R, E35D, M36I, R41K, I62V, H69K, T74S, L89M	A
Kousiappa (2009)	CY178	CY178	EU673409	None	I13V, K14N, E35D, M36I, R57K, L63T, H69K, I72T, T74S, L89M, I93IL, F99FL	A
Vercauteren (2009)	pt1139	6327463877	GQ399885	None	I13V, E35D, M36I, R57K, I62IV, L63PS, H69K, T74S, L89M, L97L*, N98NI	A
	pt1021	7094410226	GQ400003	None	L10LI, I13V, G16GE, E35D, M36I, R41K, R57K, I62V, L63IT, H69K, T74S, L89M	A
	pt728	8779959813	GQ400296	None	I13V, E35D, M36I, R41K, R57K, I62V, L63T, H69K, T74S, L89M	A
Djoko (2010)	635	CD2047	FR666635	None	E35D, M36I, R41K, Q61E, I62V, L63V, E65D, H69K, I72V, T74S, V77I, L89M	A
Ndembi (2010)	DT2794_05_P1	2794	GQ409609	None	I13V, E35D, M36I, R41K, R57K, I62V, L63V, I64M, H69K, T74S, L89M	A
Charpentier (2011)	179	CP 001 1982		None	G16A, E35D, M36L, R41K, I62V, H69K, T74S, L89M	A
El Annaz (2011)	15737	15737	HQ393321	None	T12S, I13V, K14I, I15V, L19Q, K20R, E34EG, M36I, N37NHRS, L63T, H69K, T74S, L89M, I93L	A
Hamers (2011)	CP076301543	CP076301543	HQ993586	None	I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, T74S, L89M	A
	CP076301595	CP076301595	HQ993633	None	L10I, I13V, E35D, M36I, N37D, R41K, R57K, I62V, C67Y, H69K, K70R, T74S, L89M	A
	CP076301676	CP076301676	HQ993672	None	I13V, K20R, E35D, M36I, N37D, R41K, K45R, R57RK, I62IV, H69K, T74S, L89M	A
	CP076302262	CP076302262	HQ993769	None	L10I, I13V, K20R, E35D, M36I, R41H, R57K, I62V, L63V, I64L, H69K, T74S, L89M	A
	CP076301637	CP076301637	HQ993783	None	I13V, E35D, M36I, R41K, I62V, H69K, T74S, L89M	A
	CP076301868	CP076301868	HQ995003	None	I13V, K14R, I15V, E35D, M36I, R41K, Q61E, I62V, H69K, T74S, L89M	A
	CP076302055	CP076302055	HQ995022	None	I13V, K14R, K20I, E35D, M36I, R41K, L63T, H69K, T74S, L89M	A
	CP076303001	CP076303001	HQ995069	None	I13A, K14E, K20L, M36I, R41K, H69K, T74S, L89M	A
	CP076303065	CP076303065	HQ995245	None	I13V, K20KR, E35D, M36I, R41K, R57RK, I62V, L63T, H69K, T74S, V75I, L89M	A
Ndembi (2011)	NTCPS701	NTCPS701	HQ702669	None	I13V, K14R, E35D, M36I, R41K, R57K, I62V, L63S, H69K, T74S, L89M	A
De Gascun (2012)	IRL10565	IRL10565	JN622281	None	L10I, I13IM, E35D, M36I, R41K, R57K, I62V, L63T, E65D, H69K, T74S, L89M	A
	IRL14463	IRL14463	JN622290	None	I13V, K20KR, E35D, M36I, R41K, R57RK, I62V, L63T, H69K, T74S, R87RI, L89M	A
Karlsson (2012)	SE_185	SE_185	JQ698793	None	I13V, K14S, K20I, E35D, M36I, R57K, L63T, I64L, H69K, I72T, T74S, L89M	A
Sigaloff (2012)	KELKN216	KELKN216	JN628489	None	L10V, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89M	A
	KELKN261	KELKN261	JN628520	None	L10V, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89M	A
Frentz (2013)	EHR-11577	EHR-11577	JX299726	None	I13V, E35D, M36I, R57K, I62V, L63A, H69K, I72V, T74S, L89M	A
	EHR-13657	EHR-13657	JX299764	None	I13V, K14R, G17E, K20I, L33V, E35N, M36I, R41K, D60E, L63P, H69K, T74S, L89M	A
	EHR-18756	EHR-18756	JX299849	None	I13V, E35D, M36I, R57K, I62V, L63P, H69K, T74S, L89M	A
	EHR-51234	EHR-51234	JX300393	None	I13V, K14KR, E35D, M36I, R41K, I62IV, L63T, H69K, T74S, V77I, L89M, I93L	A

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