Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	T74S
Rx	>= 1 PI
IncludeMixtures	No

References	7
Patients	13
Isolates	13

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Non-B Workgroup (2005)	UK1516	UK1516		PI, LPV	NA	I54L		L10I, I13V, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, T74S, V82VI, I85V, L89M	A
	PL9728	60099	AY901076	IDV, RTV, ATV		I54V, V82A	L33I, F53L, N83D	L10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91A	A
	TK2012	TK2012		RTV, IDV, SQV	186	I54V, L90M		L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89I	A
	TK3029	TK3029		SQV, NFV	149	L90M		L10V, I13V, K20T, E35D, M36I, R41K, H69K, T74S, L89I	A
Weber (2005)	F73291	F73291	AY677477	NFV	195	M46L	L33I, N83D	L10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93L	A
	89M2626	89M2626	AY677414	SQV, NFV, RTV	261	I54V, L90M	F53L, L89V	L10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74S	A
Baxter (2006)	48-3316	3316-30818	DQ878217	PI	NA	I54A, V82F		L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89M	A
	48-4217	4217-30915	DQ878451	PI	NA	M46L, I54V, I84V, L90M	L33F, K43T, N88G	L10I, I13V, K14R, K20R, E21Q, E35D, M36I, N37D, Q61N, I62V, L63Q, H69K, A71L, T74S, Q92R, I93M	A
	48-8053	8053-30818	DQ879078	PI	NA	M46L, G48V, I54S, V82A	L33I, F53L	L10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89I	A
von Wyl (2007)	13	662529	EF449971	PI	NA			I13V, I15V, E35D, M36I, R41K, R57K, H69K, T74S, L89M	A
Dau (2010)	11741A	11741A	GU582052	PI	NA	N88S	L10F, L89V	I13V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, T74S	A
Barber (2012)	48826	48826	JQ361679	LPV		V32I, M46I, I47A	L10F, L33I, L89V	I13V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, K70R, T74S	A
Jones (2012)	182090	182090	JN670599	PI	NA	M46I, I54V, L76V	L89V	K20P, E35N, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92K	A

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