<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation T74S
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 33
Isolates 33
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)UK1516UK1516 PI, LPVNAI54L L10I, I13V, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, T74S, V82VI, I85V, L89MA
 PL972860099AY901076IDV, RTV, ATV I54V, V82AL33I, F53L, N83DL10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91AA
 TK2012TK2012 RTV, IDV, SQV186I54V, L90M L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89IA
 TK3029TK3029 SQV, NFV149L90M L10V, I13V, K20T, E35D, M36I, R41K, H69K, T74S, L89IA
Weber (2005)F73291F73291AY677477NFV195M46LL33I, N83DL10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93LA
 89M262689M2626AY677414SQV, NFV, RTV261I54V, L90MF53L, L89VL10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74SA
Baxter (2006)48-33163316-30818DQ878217PINAI54A, V82F L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89MA
 48-42174217-30915DQ878451PINAM46L, I54V, I84V, L90ML33F, K43T, N88GL10I, I13V, K14R, K20R, E21Q, E35D, M36I, N37D, Q61N, I62V, L63Q, H69K, A71L, T74S, Q92R, I93MA
 48-80538053-30818DQ879078PINAM46L, G48V, I54S, V82AL33I, F53LL10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89IA
von Wyl (2007)13662529EF449971PINA  I13V, I15V, E35D, M36I, R41K, R57K, H69K, T74S, L89MA
Dau (2010)11741A11741AGU582052PINAN88SL10F, L89VI13V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, T74SA
Barber (2012)4882648826JQ361679LPV V32I, M46I, I47AL10F, L33I, L89VI13V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, K70R, T74SA
Jones (2012)182090182090JN670599PINAM46I, I54V, L76VL89VK20P, E35N, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92KA
Kouri (2012)CU2041-09CU2041-09JQ585335PINAM46I, I54VL33I, G73SI13V, K14R, K20I, E35D, M36I, H69K, A71V, T74S, V75I, L89TA
 CU727-09CU727-09JQ585262PINAG48V, I54V, V82AF53LL10I, I13V, I15V, K20I, E35D, M36I, R41K, I64M, H69K, T74S, L89MA
 CU376-10CU376-10JQ585390PINAG48V, I54V, V82A L10V, T12I, I13V, K20I, E35D, M36I, N37DE, R41K, H69K, T74S, L89IA
 CU2007-09CU2007-09JQ585330PINAM46I, I54V, V82A, I84VL24I, L33FL10I, T12S, G16A, L19I, K20V, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74S, L89M, I93LA
Avidor (2013)989_MT989_MTKC184397NFV L90ML10LFI13V, K20T, E35D, M36I, R41K, H69K, A71AV, T74S, L89I, I93LA
Grossman (2014)792792KC184392LPV52  I13V, E35D, M36I, R41K, H69K, T74S, L89M, I93LA
Kolomeets (2014)7676_88KJ870262LPV   L10LI, I13V, E35D, M36I, R41K, Q61E, L63T, E65D, H69K, T74S, L89M, I93LA
 175175_272KJ870393PINAM46LL10FI13V, M36I, R41K, H69K, T74S, V77I, L89MA
 273273_442KJ870527LPV   L10I, I13V, K14KR, G16E, E35EDKN, M36I, R41K, I62V, H69K, T74S, V77I, L89MA
 474474_650KJ870672LPV   I13V, E35D, M36I, R41K, L63LIPT, H69K, T74S, L89M, I93LA
Steegen (2014)12ZAKS19512ZAKS195KJ176476LPV M46I, I54V, L76V, V82A Q61QH, I62V, L63V, H69K, T74S, L89M, I93LA
Diaz (2015)RenG16257RenG16257KT747285PINAM46I, I54V, L76V, V82AL24IL10I, I13V, K20M, E35D, M36I, N37D, R41K, K55R, R57K, Q61N, I62V, L63P, A71T, I72T, T74S, L89IA
 RenG14395RenG14395KT745423PINAN88S I15V, K20T, E35H, M36I, P39S, R41K, R57K, Q61N, L63C, E65D, T74S, L89MA
 RenG13633RenG13633KT744661PINAM46I, I47A, I84V, L90ML10F, V11I, F53L, G73S, L89VI13V, I15V, K20T, E35N, M36I, R41K, K55R, R57K, Q61N, L63P, A71V, T74S, T91S, I93LA
 RenG15167RenG15167KT746195PINAG48M, I54V, V82A, L90MK43T, F53LL10IV, V11L, T12P, I13V, K20I, E35D, M36I, N37K, R41K, R57K, Q61N, L63P, T74S, L89I, Q92KA
 RenG15076RenG15076KT746104PINAM46I, V82FF53L, N83DW6V, L10V, I13A, A22V, E35D, M36I, R41K, K43R, R57K, Q61N, I62V, L63P, H69R, T74S, L89I, I93LA
 RenG13889RenG13889KT744917PINAG48V, I54T, V82AK43KTL10I, T12S, I13V, K20M, E35D, M36I, R41K, R57K, Q61N, T74S, L89I, N98K, F99FLA
 RenG11829RenG11829KT742857PINAM46I, I47A, I84V, L90MF53LL10Y, I13V, I15V, K20IT, E35DG, M36I, R41K, R57K, Q61N, L63P, A71V, T74S, L89I, I93LA
 RenG12636RenG12636KT743664PINAD30N, V32VI, M46I, I47V, I54LVF53FL, L76LM, N88DL10V, T12IM, I13A, K20T, A22AV, E35N, M36I, N37ND, R41K, K45R, R57K, Q61N, L63C, A71V, T74S, L89T, Q92RA
 RenG10743RenG10743KT741771PINAM46I, I54IV, V82VA, L90ML23LI, F53FLL10IV, T12K, I13V, K14W, G16E, L19P, K20V, E35G, M36I, N37D, R41K, I62V, L63H, I64V, H69K, A71I, T74S, V77I, L89M, I93MA