Protease Inhibitors

HOME Genotype-Rx Genotype-Pheno Genotype-Clinical hivdb program

Protease Inhibitors

Subtype	A
Gene	PR
Mutation	L63V
Rx	PI-naive
IncludeMixtures	No

References	56
Patients	129
Isolates	131

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Pieniazek (1998)	LE-5	LE5	AF025741	None		L10I, I13V, G16E, E35D, M36I, R41K, L63V, C67Y, H69K, L89M, T91P	A
	LE-4	LE4	AF025740	None		L10I, E35D, M36I, R41K, L63V, H69K, L89M, T91P	A
Becker-Pergola (2000)	190.574	BPG190-574	AF177353	None		I13V, K14R, E35D, M36I, R41K, R57K, L63V, I64M, H69K, L89M	A
Koch (2001)	NK-18	NK-18	AY007747	None	L33F	L10I, I13V, K14R, K20R, M36I, R41K, R57K, L63V, H69Q, K70R, L89M	A
Dowling (2002)	KER2012	KER2012	AF457055	None		L10I, I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
Fonjungo (2002)	CM133	CM133	AF406711	None		I13V, E35N, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93L	A
Gibb (2002)	DMG66	66_w3		None		I13V, G16E, E35D, M36I, R41K, L63V, G68GE, H69K, L89M, T91V, I93L	A
Hierholzer (2002)	SU238	SU238	AY102494	None		L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63V, H69K, L89M	A
Eshleman (2004)	SE164	SE164p	AY435390	None		I13V, E35D, M36I, R41K, R57K, L63V, H69K, I72V, T74S, L89M	A
		SE164_7d	AY428678	None		I13V, E35D, M36I, R41K, R57K, L63V, H69K, I72V, T74TS, L89M	A
Eshleman (2004)	ESH_Pat16	ESH253	AY435264	None		L10IV, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, K45KR, R57K, L63V, H69K, I85IV, L89M	A
Eshleman (2004)	225_692	225_692	AY444195	None	V11I	I13V, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93L	A
Kijak (2004)	3163MN	02CM.3163	AY371160	None		L10V, I15V, K20R, E35D, M36I, N37H, R41K, I62V, L63V, K70Q, I72T, L89M	A
Servais (2004)	SJ_Pat14	SJKLM051	AJ412971	None		L10V, I13V, K14KR, G16E, E35D, M36I, R41K, K45R, R57K, L63V, H69K, L89M	A
	SJ_Pat28	SJKLM024	AJ412950	None		I13V, K14R, E35D, M36I, R41K, R57K, I62V, L63V, H69K, T74A, L89M	A
	SJ_Pat40	SJKLM046	AJ412966	None		L10I, I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
Carr (2005)	03UZ069	03UZ069	AY845774	None		K14R, G16E, E35D, M36I, R41K, R57K, L63V, H69K, L89M, I93L	A
Grossman (2005)	23875	23875PR320		None		I13IV, K14KR, I15IV, E35D, M36I, N37ND, R41K, I62IV, L63V, I64IM, H69K, L89M, I93L	A
Holguin (2005)	2764-00	00_2764-00	AY248327	None		L10I, I13V, M36I, R41K, L63V, H69K, T74S, L89M	A
Non-B Workgroup (2005)	UK1978	UK1978	AY900825	None		I13V, E35D, M36I, R41K, L63V, H69K, L89M	A
Punzi (2005)	CAR-30	CAR-30	AY626953	None		E35D, M36I, R41K, I62V, L63V, I64L, H69K, V77I, L89M	A
Marechal (2006)	JF_079	JF_079	DQ443679	None		G16E, E35D, M36I, R41K, I62V, L63V, G68E, H69K, K70R, L89M, T91V, I93L	A
Vessiere (2006)	AV_M4415N	AV_M4415N	DQ297267	None		L10I, I13V, G16E, K20V, E35D, M36I, L63V, H69K, L89M	A
Zarandia (2006)	MZ_03GEMZ038	03GEMZ038	DQ205292	None		L10I, I13V, E35D, M36I, R41K, L63V, C67CY, H69K, V82I, N83X, L89M	A
Galluzzo (2007)	M22310	UG_M22310	JQ220071	None		G16E, E35D, M36I, R41K, R57K, L63V, E65D, H69K, L89M	A
Razafindratsimandresy (2007)	43	43HIV-SEY	EF143534	None		I13V, G16A, E35D, M36I, R41K, R57K, L63V, H69K, V82I, L89M, I93L	A
Vidal (2007)	U3126	02BU.U3126	AM260255	None		L10V, I13V, E35D, M36I, R41K, D60E, Q61E, L63V, H69K, L89M	A
von Wyl (2007)	76	5808752	EF449852	None		I13V, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93L	A
Chang (2008)	TW3452a	TW3452a		None		L10I, I13V, K14R, G16E, K20R, E35D, M36I, R41K, L63V, H69K, L89M	A
Church (2008)	349844H	349844H	EU380725	None		L10LV, I13V, G16GE, L19LI, K20KR, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	417659J	417659J	EU380760	None		L10V, I13V, G16E, L19I, E35DY, M36I, R41K, Q61H, L63V, H69K, L89M	A
Ibe (2008)	169	169	AB356216	None		L10V, I13V, K20R, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
Lall (2008)	G3	G3-AFMC1	EU158864	None		L10I, I13V, E35D, M36I, N37D, R41K, K45R, R57K, L63V, H69K, N83H, L89M, N98D	A
Nyombi (2008)	TMS011	TMS011	EU251791	None		L10M, I13V, E35D, M36I, R41K, K45R, R57K, L63V, H69K, L89M	A
Sylla (2008)	A1424	A1424_C1	EF525664	None		L10V, T12P, I13V, K14R, G16E, E35D, M36I, R41K, L63V, H69K, K70R, L89M	A
		A1424_C2	EF525665	None		L10V, T12P, I13V, K14R, G16E, E35D, M36I, R41K, L63V, H69K, K70R, L89M	A
Aghokeng (2009)	HU_0017	HU_0017	GU191668	None		L10I, I13V, L19LI, E35D, M36I, R41K, R57K, L63V, H69K, V77I, L89M	A
Avi (2009)	U40	U40	FJ154009	None		I13V, K14R, G16E, K20R, E35D, M36I, R41K, K43R, L63V, H69K, L89M, I93L	A
Bartolo (2009)	CSE117	01AOCSE117	EU068200	None		L10V, I13V, I15V, G16E, M36I, N37D, R41K, L63V, H69K, L89M	A
	CSE136	01AOCSE136	EU068213	None		L10V, I13V, I15V, G16E, M36I, R41K, L63V, I64M, H69K, L89M	A
	HDP112	01AOHDP112	EU068236	None		L10I, I13V, E35D, M36I, R41K, L63V, C67Y, H69K, L89M	A
	LFA17	01AOLFA17	EU068267	None		L10I, I13V, M36I, N37D, R41K, L63V, H69K, L89M	A
	LFA19	01AOLFA19	EU068269	None		L10I, I13V, M36I, N37D, R41K, L63V, H69K, L89M	A
	HM185	01AOHM185	EU068324	None		L10I, I13V, M36I, N37D, R41K, L63V, H69K, L89M	A
Cuevas (2009)	P1003	P1003.1	EU822541	None		I13V, G16E, L19Q, K20R, E35D, M36I, R41K, L63V, H69K, L89M, T91V, I93L	A
Eshleman (2009)	D40933W3	07-156928	FJ389067	None		I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	H45372W3	08-101507	FJ389110	None		L10I, K14R, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
Kousiappa (2009)	CY111	CY111	EU673394	None		L10I, T12P, I13V, G16E, L19V, K20R, E35D, M36I, R41K, L63V, H69Q, L89M, I93M	A
	CY112	CY112	EU673395	None		L10I, I13V, K14N, G16E, L19V, K20R, E35D, M36I, R41K, L63V, H69Q, L89M, Q92QH, I93M	A
Steegen (2009)	BV147	BV147-2	EU878549	None		L10LI, I13V, G16E, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93L	A
Tebit (2009)	TR185	TR185	FJ577324	None		L10I, I13V, K14R, G16E, E35D, M36I, L63V, H69K, L89M	A
Thomson (2009)	D9	RU_D9	FJ009779	None		L10I, I13V, K14R, E35D, M36I, R41K, L63V, H69K, L89IM, I93L	A
Vercauteren (2009)	pt1384	4961679171	GQ399640	None		L10I, I13V, Q18H, E35D, M36I, R41K, L63V, H69K, K70KR, L89LM, T96TA	A
	pt1170	6162713890	GQ399854	None	V11VI	L10I, I13V, E35D, M36I, N37E, R41K, R57K, L63V, H69K, L89M	A
	pt959	7484273043	GQ400065	None		L10V, I13V, E35D, M36I, R41K, I62IV, L63V, H69R, I72V, L89M	A
	pt933	7660728886	GQ400091	None		E35D, M36I, R41K, R57RK, L63V, H69K, L89M	A
	pt674	8oxBGvibBI	GQ400350	None		K20R, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	pt583	9488058847	GQ400441	None		L10I, I13V, Q18H, E35D, M36I, R41K, L63V, H69K, K70KR, L89LM, T96TA	A
Carr (2010)	4038STN	01CM.4038STN	GU201508	None		I13V, K20R, E35G, M36I, R41K, R57K, L63V, I64M, H69K, L89M	A
	1445MV	01CM.1445MV	GU201516	None		I13V, G16E, E35D, M36I, R41K, K43R, L63V, G68E, H69K, K70R, L89I, T91V, I93L	A
Djoko (2010)	635	CD2047	FR666635	None		E35D, M36I, R41K, Q61E, I62V, L63V, E65D, H69K, I72V, T74S, V77I, L89M	A
	645	CD2084	FR666645	None		L10I, I13V, L19I, M36I, R41K, L63V, C67HY, H69K, L89M	A
	646	CD3373	FR666646	None		L10I, I13V, E35D, M36I, N37D, R41K, L63V, H69K, L89M	A
	673	CD3191	FR666673	None		I13V, G16A, E35D, M36I, N37D, R41K, K43R, R57K, L63V, H69K, I72IM, L89M	A
Djoko (2010)	GQ281	08GQ281	FN557312	None		L10V, I13V, E35D, M36I, R41K, L63V, H69K, V77VI, L89M	A
Ndembi (2010)	13020D_P1	13020	GQ409546	None		L10I, I13V, K14R, I15V, G16E, E35D, M36I, R41K, R57K, L63V, H69K, K70R, L89M	A
	16712D_P1	16712	GQ409588	None		L10I, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	DT1515_04_P1	1515	GQ409600	None		E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	DT2794_05_P1	2794	GQ409609	None		I13V, E35D, M36I, R41K, R57K, I62V, L63V, I64M, H69K, T74S, L89M	A
	DT3504_05_P1	3504	GQ409618	None		G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93L	A
Tovanabutra (2010)	KECst_017	KECst_017	FJ623488	None		L10V, I13V, I15V, L19V, E35D, M36L, N37D, R41K, R57K, D60E, Q61E, L63V, E65D, H69K, L89M	A
	KECst_027	KECst_027	FJ623492	None		I13V, I15V, G16E, M36I, R41K, Q61E, L63V, G68E, H69K, K70R, L89M, T91V	A
Towler (2010)	337081-S	337081-S	HM037852	None		L10M, I13V, K14R, M36I, R41K, L63V, H69K, L89M	A
Fokam (2011)	CIRCB-11689	CIRCB-11689	JQ796138	None		L10I, I13V, G16E, K20I, E35D, M36I, L63V, H69N, L89M	A
Hamers (2011)	CP076301530	CP076301530	HQ993575	None		L10I, I13V, K14R, I15V, E35D, M36I, N37D, R57K, L63V, H69K, L89M	A
	CP076301541	CP076301541	HQ993584	None		I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63V, I64M, H69K, L89M	A
	CP076301543	CP076301543	HQ993586	None		I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, T74S, L89M	A
	CP076301567	CP076301567	HQ993608	None		I13V, G16GE, K20R, E35N, M36I, N37D, R41K, K45R, L63V, H69K, L89M	A
	CP076301588	CP076301588	HQ993626	None		T12TP, I13V, G16A, K20R, E35D, M36I, R41K, L63V, G68E, H69K, L89M, T91V, I93L	A
	CP076301611	CP076301611	HQ993648	None		G16E, K20R, E35D, M36I, N37D, R41RK, Q61QH, L63V, G68E, H69K, K70R, L89M, T91V, I93L	A
	CP076301681	CP076301681	HQ993677	None		I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57K, Q61H, L63V, G68E, H69K, K70R, L89I, T91V, I93L	A
	CP076301699	CP076301699	HQ993694	None		I13V, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, L89M, T91V, I93L	A
	CP076301705	CP076301705	HQ993700	None		L10I, I13V, Q18QE, K20R, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	CP076301727	CP076301727	HQ993720	None		I13V, I15V, E35D, M36I, R41K, R57K, I62V, L63V, I64M, H69K, K70KR, L89M	A
	CP076301742	CP076301742	HQ993732	None		I15IV, G16E, K20R, E35D, M36I, R41K, R57K, L63V, H69K, L89M, I93L	A
	CP076301753	CP076301753	HQ993742	None		L10LI, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	CP076301772	CP076301772	HQ993758	None		L10I, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	CP076302234	CP076302234	HQ993766	None		G16E, E35D, M36I, R41K, L63V, H69K, L89M, T91V, I93IL	A
	CP076302253	CP076302253	HQ993767	None		L10V, I13V, G16E, E35D, M36I, R41K, K45R, R57K, L63V, H69K, L89M	A
	CP076302262	CP076302262	HQ993769	None		L10I, I13V, K20R, E35D, M36I, R41H, R57K, I62V, L63V, I64L, H69K, T74S, L89M	A
	CP076301631	CP076301631	HQ993780	None		L10V, I13V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, I62V, L63V, I64M, E65D, H69K, L89M	A
	CP076301646	CP076301646	HQ993790	None		I13IV, K14KR, E35D, M36I, N37D, R41K, R57K, L63V, H69K, L89M	A
	CP076301654	CP076301654	HQ993797	None		I13V, I15V, G16E, K20R, E35D, M36I, N37D, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93L	A
	CP076302289	CP076302289	HQ993838	None		T12TA, K14KR, I15V, K20R, M36I, R41K, R57K, L63V, H69K, K70R, L89M	A
	CP076302296	CP076302296	HQ993843	None		L10I, I13V, G16E, E35N, M36I, P39T, R41K, R57K, L63V, H69K, L89M	A
	CP076302305	CP076302305	HQ993851	None		L10I, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63V, H69Q, I72IV, L89M	A
	CP076304205	CP076304205	HQ993907	None		I13V, I15IV, E35D, M36I, R41K, R57K, L63V, I64M, H69K, L89M	A
	CP076304221	CP076304221	HQ993916	None		I13V, G16E, K20R, E35D, M36I, R41K, I62V, L63V, I64M, H69K, L89M	A
	CP076304240	CP076304240	HQ993933	None		L10V, K20R, E35D, M36I, N37D, R41K, K43R, R57K, L63V, E65D, H69K, L89M	A
	CP076304274	CP076304274	HQ993961	None		I13V, K14R, G16E, E35D, M36V, R41K, K45R, R57K, L63V, H69K, L89M	A
	CP076301847	CP076301847	HQ994992	None		I13V, G16E, E35D, M36I, R41K, L63V, I64L, H69K, K70R, L89M, T91V, I93L	A
	CP076300874	CP076300874	HQ995131	None	V11I	I13V, G16A, M36I, R41K, R57K, L63V, H69K, L89M	A
	CP076302044	CP076302044	HQ995199	None		L10V, I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	CP076302077	CP076302077	HQ995209	None		L10V, I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	CP076303064	CP076303064	HQ995244	None		L10V, I13V, I15V, L19I, E35D, M36I, R41K, R57K, L63V, I64M, H69K, L89M	A
	CP076300788	CP076300788	HQ995352	None		I13V, K14R, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	CP076300799	CP076300799	HQ995360	None		I13V, K14R, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	CP076301926	CP076301926	HQ995397	None		Q2L, T12A, I13V, K20R, E35D, M36I, N37D, R41K, R57K, Q61E, L63V, E65D, H69K, L89M	A
	CP076302432	CP076302432	HQ995492	None		I15V, L19Q, K20R, M36I, R41K, L63V, H69K, L89M, I93L	A
Kasang (2011)	23282	23282	HM572375	None	G48GR	L10V, E35D, M36I, R41K, R57K, L63V, G68GR, H69K, L89M	A
Ndembi (2011)	AICPS107	AICPS107	HQ702634	None		L10I, I13V, E35D, M36I, R41K, R57K, L63V, H69Q, L89M	A
	AICPS435	AICPS435	HQ702635	None		I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
	AICPS001	AICPS001	HQ702677	None	L33F	I13V, K14R, G17D, E35D, M36T, R41K, R57K, L63V, E65D, H69K, V77I, L89M	A
Caron (2012)	Gab052267	Gab052267	JN704996	None		L10V, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
Hassan (2012)	RS09000886	RS09000886	HQ441631	None		I13IV, K14KR, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93L	A
	RS09000918	RS09000918	HQ441662	None		I13V, E35D, M36I, R41K, R57K, L63V, H69K, K70KR, L89M	A
	RS09000967	RS09000967	HQ441705	None		I13V, G16E, E35D, M36I, R41K, L63V, H69K, L89M, T91V, I93L	A
	RS09000970	RS09000970	HQ441708	None		I13V, G16E, K20R, E35D, M36I, R41K, Q61H, L63V, G68E, H69K, K70R, V82VI, L89M, T91V, I93L	A
	RS09000980	RS09000980	HQ441715	None		I13IV, L19I, K20R, E35D, M36I, N37D, R41K, L63V, H69K, L89M, T91V	A
	RS11000293	RS11000293	JQ698380	None		I13V, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70KR, L89M, T91V, I93L	A
	RS11000300	RS11000300	JQ698385	None		G16E, K20R, M36I, R41K, L63V, G68E, H69K, L89M, T91V, I93L	A
	RS11000320	RS11000320	JQ698398	None		T12P, I13V, G16E, K20R, E35D, M36I, R41K, Q61E, L63V, G68E, H69K, K70R, V82I, L89M, T91V, I93L	A
Sigaloff (2012)	KECGP053	KECGP053	JN628468	None		L10I, I13V, K14R, E21D, E35D, M36I, N37D, R41K, R57K, L63V, H69K, L89M, L97I	A
	KEKSN414	KEKSN414	JN628478	None		L10I, K14N, G16E, E35D, M36I, P39T, R41K, I62V, L63V, H69K, L89M	A
	KELKN216	KELKN216	JN628489	None		L10V, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89M	A
	KELKN261	KELKN261	JN628520	None		L10V, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89M	A
	KELKN262	KELKN262	JN628521	None		I13V, G16E, K20R, E35D, M36I, R41K, L63V, H69K, K70R, L89M, I93L	A
	KELKN266	KELKN266	JN628524	None	L33F	I13V, K14R, E35D, M36I, R41K, R57K, L63V, H69K, L89M, L97I	A
Yang (2012)	KN-96	KN-96	JQ616925	None		T12S, I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89M	A
Youngpairoj (2012)	cm8bb	cm8bb	DQ166432	None		L10I, I13V, G16E, K20I, E35D, M36I, L63V, H69K, L89M	A
Frentz (2013)	EHR-97837	EHR-97837	JX301143	None		T12P, E35D, M36I, R41K, L63V, H69K, V77I, L89M	A

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