<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L63V
Rx PI-naive
IncludeMixtures No
References 66
Patients 147
Isolates 150
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Pieniazek (1998)LE-5LE5AF025741None   L10I, I13V, G16E, E35D, M36I, R41K, L63V, C67Y, H69K, L89M, T91PA
 LE-4LE4AF025740None   L10I, E35D, M36I, R41K, L63V, H69K, L89M, T91PA
Becker-Pergola (2000)190.574BPG190-574AF177353None   I13V, K14R, E35D, M36I, R41K, R57K, L63V, I64M, H69K, L89MA
Koch (2001)NK-18NK-18AY007747None  L33FL10I, I13V, K14R, K20R, M36I, R41K, R57K, L63V, H69Q, K70R, L89MA
Dowling (2002)KER2012KER2012AF457055None   L10I, I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
Fonjungo (2002)CM133CM133AF406711None   I13V, E35N, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93LA
Gibb (2002)DMG6666_w3 None   I13V, G16E, E35D, M36I, R41K, L63V, G68GE, H69K, L89M, T91V, I93LA
Hierholzer (2002)SU238SU238AY102494None   L10V, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63V, H69K, L89MA
Eshleman (2004)SE164SE164pAY435390None   I13V, E35D, M36I, R41K, R57K, L63V, H69K, I72V, T74S, L89MA
  SE164_7dAY428678None   I13V, E35D, M36I, R41K, R57K, L63V, H69K, I72V, T74TS, L89MA
Eshleman (2004)ESH_Pat16ESH253AY435264None   L10IV, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, K45KR, R57K, L63V, H69K, I85IV, L89MA
Eshleman (2004)225_692225_692AY444195None  V11II13V, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93LA
Kijak (2004)3163MN02CM.3163AY371160None   L10V, I15V, K20R, E35D, M36I, N37H, R41K, I62V, L63V, K70Q, I72T, L89MA
Servais (2004)SJ_Pat14SJKLM051AJ412971None   L10V, I13V, K14KR, G16E, E35D, M36I, R41K, K45R, R57K, L63V, H69K, L89MA
 SJ_Pat28SJKLM024AJ412950None   I13V, K14R, E35D, M36I, R41K, R57K, I62V, L63V, H69K, T74A, L89MA
 SJ_Pat40SJKLM046AJ412966None   L10I, I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
Carr (2005)03UZ06903UZ069AY845774None   K14R, G16E, E35D, M36I, R41K, R57K, L63V, H69K, L89M, I93LA
Grossman (2005)2387523875PR320 None   I13IV, K14KR, I15IV, E35D, M36I, N37ND, R41K, I62IV, L63V, I64IM, H69K, L89M, I93LA
Holguin (2005)2764-0000_2764-00AY248327None   L10I, I13V, M36I, R41K, L63V, H69K, T74S, L89MA
Non-B Workgroup (2005)UK1978UK1978AY900825None   I13V, E35D, M36I, R41K, L63V, H69K, L89MA
Punzi (2005)CAR-30CAR-30AY626953None   E35D, M36I, R41K, I62V, L63V, I64L, H69K, V77I, L89MA
Marechal (2006)JF_079JF_079DQ443679None   G16E, E35D, M36I, R41K, I62V, L63V, G68E, H69K, K70R, L89M, T91V, I93LA
Vessiere (2006)AV_M4415NAV_M4415NDQ297267None   L10I, I13V, G16E, K20V, E35D, M36I, L63V, H69K, L89MA
Zarandia (2006)MZ_03GEMZ03803GEMZ038DQ205292None   L10I, I13V, E35D, M36I, R41K, L63V, C67CY, H69K, V82I, N83X, L89MA
Galluzzo (2007)M22310UG_M22310JQ220071None   G16E, E35D, M36I, R41K, R57K, L63V, E65D, H69K, L89MA
Razafindratsimandresy (2007)4343HIV-SEYEF143534None   I13V, G16A, E35D, M36I, R41K, R57K, L63V, H69K, V82I, L89M, I93LA
Vidal (2007)U312602BU.U3126AM260255None   L10V, I13V, E35D, M36I, R41K, D60E, Q61E, L63V, H69K, L89MA
von Wyl (2007)765808752EF449852None   I13V, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93LA
Chang (2008)TW3452aTW3452a None   L10I, I13V, K14R, G16E, K20R, E35D, M36I, R41K, L63V, H69K, L89MA
Church (2008)349844H349844HEU380725None   L10LV, I13V, G16GE, L19LI, K20KR, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 417659J417659JEU380760None   L10V, I13V, G16E, L19I, E35DY, M36I, R41K, Q61H, L63V, H69K, L89MA
Ibe (2008)169169AB356216None   L10V, I13V, K20R, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
Lall (2008)G3G3-AFMC1EU158864None   L10I, I13V, E35D, M36I, N37D, R41K, K45R, R57K, L63V, H69K, N83H, L89M, N98DA
Nyombi (2008)TMS011TMS011EU251791None   L10M, I13V, E35D, M36I, R41K, K45R, R57K, L63V, H69K, L89MA
Sylla (2008)A1424A1424_C1EF525664None   L10V, T12P, I13V, K14R, G16E, E35D, M36I, R41K, L63V, H69K, K70R, L89MA
  A1424_C2EF525665None   L10V, T12P, I13V, K14R, G16E, E35D, M36I, R41K, L63V, H69K, K70R, L89MA
Aghokeng (2009)HU_0017HU_0017GU191668None   L10I, I13V, L19LI, E35D, M36I, R41K, R57K, L63V, H69K, V77I, L89MA
Avi (2009)U40U40FJ154009None   I13V, K14R, G16E, K20R, E35D, M36I, R41K, K43R, L63V, H69K, L89M, I93LA
Bartolo (2009)CSE11701AOCSE117EU068200None   L10V, I13V, I15V, G16E, M36I, N37D, R41K, L63V, H69K, L89MA
 CSE13601AOCSE136EU068213None   L10V, I13V, I15V, G16E, M36I, R41K, L63V, I64M, H69K, L89MA
 HDP11201AOHDP112EU068236None   L10I, I13V, E35D, M36I, R41K, L63V, C67Y, H69K, L89MA
 LFA1701AOLFA17EU068267None   L10I, I13V, M36I, N37D, R41K, L63V, H69K, L89MA
 LFA1901AOLFA19EU068269None   L10I, I13V, M36I, N37D, R41K, L63V, H69K, L89MA
 HM18501AOHM185EU068324None   L10I, I13V, M36I, N37D, R41K, L63V, H69K, L89MA
Cuevas (2009)P1003P1003.1EU822541None   I13V, G16E, L19Q, K20R, E35D, M36I, R41K, L63V, H69K, L89M, T91V, I93LA
Eshleman (2009)D40933W307-156928FJ389067None   I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 H45372W308-101507FJ389110None   L10I, K14R, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
Kousiappa (2009)CY111CY111EU673394None   L10I, T12P, I13V, G16E, L19V, K20R, E35D, M36I, R41K, L63V, H69Q, L89M, I93MA
 CY112CY112EU673395None   L10I, I13V, K14N, G16E, L19V, K20R, E35D, M36I, R41K, L63V, H69Q, L89M, Q92QH, I93MA
Steegen (2009)BV147BV147-2EU878549None   L10LI, I13V, G16E, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93LA
Tebit (2009)TR185TR185FJ577324None   L10I, I13V, K14R, G16E, E35D, M36I, L63V, H69K, L89MA
Thomson (2009)D9RU_D9FJ009779None   L10I, I13V, K14R, E35D, M36I, R41K, L63V, H69K, L89IM, I93LA
Vercauteren (2009)pt13844961679171GQ399640None   L10I, I13V, Q18H, E35D, M36I, R41K, L63V, H69K, K70KR, L89LM, T96TAA
 pt11706162713890GQ399854None  V11VIL10I, I13V, E35D, M36I, N37E, R41K, R57K, L63V, H69K, L89MA
 pt9597484273043GQ400065None   L10V, I13V, E35D, M36I, R41K, I62IV, L63V, H69R, I72V, L89MA
 pt9337660728886GQ400091None   E35D, M36I, R41K, R57RK, L63V, H69K, L89MA
 pt6748oxBGvibBIGQ400350None   K20R, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 pt5839488058847GQ400441None   L10I, I13V, Q18H, E35D, M36I, R41K, L63V, H69K, K70KR, L89LM, T96TAA
Carr (2010)4038STN01CM.4038STNGU201508None   I13V, K20R, E35G, M36I, R41K, R57K, L63V, I64M, H69K, L89MA
 1445MV01CM.1445MVGU201516None   I13V, G16E, E35D, M36I, R41K, K43R, L63V, G68E, H69K, K70R, L89I, T91V, I93LA
Djoko (2010)635CD2047FR666635None   E35D, M36I, R41K, Q61E, I62V, L63V, E65D, H69K, I72V, T74S, V77I, L89MA
 645CD2084FR666645None   L10I, I13V, L19I, M36I, R41K, L63V, C67HY, H69K, L89MA
 646CD3373FR666646None   L10I, I13V, E35D, M36I, N37D, R41K, L63V, H69K, L89MA
 673CD3191FR666673None   I13V, G16A, E35D, M36I, N37D, R41K, K43R, R57K, L63V, H69K, I72IM, L89MA
Djoko (2010)GQ28108GQ281FN557312None   L10V, I13V, E35D, M36I, R41K, L63V, H69K, V77VI, L89MA
Ndembi (2010)13020D_P113020GQ409546None   L10I, I13V, K14R, I15V, G16E, E35D, M36I, R41K, R57K, L63V, H69K, K70R, L89MA
 16712D_P116712GQ409588None   L10I, I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 DT1515_04_P11515GQ409600None   E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 DT2794_05_P12794GQ409609None   I13V, E35D, M36I, R41K, R57K, I62V, L63V, I64M, H69K, T74S, L89MA
 DT3504_05_P13504GQ409618None   G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93LA
Tovanabutra (2010)KECst_017KECst_017FJ623488None   L10V, I13V, I15V, L19V, E35D, M36L, N37D, R41K, R57K, D60E, Q61E, L63V, E65D, H69K, L89MA
 KECst_027KECst_027FJ623492None   I13V, I15V, G16E, M36I, R41K, Q61E, L63V, G68E, H69K, K70R, L89M, T91VA
Towler (2010)337081-S337081-SHM037852None   L10M, I13V, K14R, M36I, R41K, L63V, H69K, L89MA
Fokam (2011)CIRCB-11689CIRCB-11689JQ796138None   L10I, I13V, G16E, K20I, E35D, M36I, L63V, H69N, L89MA
Hamers (2011)CP076301530CP076301530HQ993575None   L10I, I13V, K14R, I15V, E35D, M36I, N37D, R57K, L63V, H69K, L89MA
 CP076301541CP076301541HQ993584None   I15V, K20R, E35D, M36I, R41K, R57K, I62V, L63V, I64M, H69K, L89MA
 CP076301543CP076301543HQ993586None   I13V, I15V, K20R, E35D, M36I, R41K, I62V, L63V, H69K, T74S, L89MA
 CP076301567CP076301567HQ993608None   I13V, G16GE, K20R, E35N, M36I, N37D, R41K, K45R, L63V, H69K, L89MA
 CP076301588CP076301588HQ993626None   T12TP, I13V, G16A, K20R, E35D, M36I, R41K, L63V, G68E, H69K, L89M, T91V, I93LA
 CP076301611CP076301611HQ993648None   G16E, K20R, E35D, M36I, N37D, R41RK, Q61QH, L63V, G68E, H69K, K70R, L89M, T91V, I93LA
 CP076301681CP076301681HQ993677None   I13V, K14R, G16E, K20R, E35D, M36I, R41K, R57K, Q61H, L63V, G68E, H69K, K70R, L89I, T91V, I93LA
 CP076301699CP076301699HQ993694None   I13V, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, L89M, T91V, I93LA
 CP076301705CP076301705HQ993700None   L10I, I13V, Q18QE, K20R, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 CP076301727CP076301727HQ993720None   I13V, I15V, E35D, M36I, R41K, R57K, I62V, L63V, I64M, H69K, K70KR, L89MA
 CP076301742CP076301742HQ993732None   I15IV, G16E, K20R, E35D, M36I, R41K, R57K, L63V, H69K, L89M, I93LA
 CP076301753CP076301753HQ993742None   L10LI, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 CP076301772CP076301772HQ993758None   L10I, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 CP076302234CP076302234HQ993766None   G16E, E35D, M36I, R41K, L63V, H69K, L89M, T91V, I93ILA
 CP076302253CP076302253HQ993767None   L10V, I13V, G16E, E35D, M36I, R41K, K45R, R57K, L63V, H69K, L89MA
 CP076302262CP076302262HQ993769None   L10I, I13V, K20R, E35D, M36I, R41H, R57K, I62V, L63V, I64L, H69K, T74S, L89MA
 CP076301631CP076301631HQ993780None   L10V, I13V, I15V, K20R, E35D, M36I, N37D, R41K, R57K, I62V, L63V, I64M, E65D, H69K, L89MA
 CP076301646CP076301646HQ993790None   I13IV, K14KR, E35D, M36I, N37D, R41K, R57K, L63V, H69K, L89MA
 CP076301654CP076301654HQ993797None   I13V, I15V, G16E, K20R, E35D, M36I, N37D, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93LA
 CP076302289CP076302289HQ993838None   T12TA, K14KR, I15V, K20R, M36I, R41K, R57K, L63V, H69K, K70R, L89MA
 CP076302296CP076302296HQ993843None   L10I, I13V, G16E, E35N, M36I, P39T, R41K, R57K, L63V, H69K, L89MA
 CP076302305CP076302305HQ993851None   L10I, I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63V, H69Q, I72IV, L89MA
 CP076304205CP076304205HQ993907None   I13V, I15IV, E35D, M36I, R41K, R57K, L63V, I64M, H69K, L89MA
 CP076304221CP076304221HQ993916None   I13V, G16E, K20R, E35D, M36I, R41K, I62V, L63V, I64M, H69K, L89MA
 CP076304240CP076304240HQ993933None   L10V, K20R, E35D, M36I, N37D, R41K, K43R, R57K, L63V, E65D, H69K, L89MA
 CP076304274CP076304274HQ993961None   I13V, K14R, G16E, E35D, M36V, R41K, K45R, R57K, L63V, H69K, L89MA
 CP076301847CP076301847HQ994992None   I13V, G16E, E35D, M36I, R41K, L63V, I64L, H69K, K70R, L89M, T91V, I93LA
 CP076300874CP076300874HQ995131None  V11II13V, G16A, M36I, R41K, R57K, L63V, H69K, L89MA
 CP076302044CP076302044HQ995199None   L10V, I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 CP076302077CP076302077HQ995209None   L10V, I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 CP076303064CP076303064HQ995244None   L10V, I13V, I15V, L19I, E35D, M36I, R41K, R57K, L63V, I64M, H69K, L89MA
 CP076300788CP076300788HQ995352None   I13V, K14R, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 CP076300799CP076300799HQ995360None   I13V, K14R, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 CP076301926CP076301926HQ995397None   Q2L, T12A, I13V, K20R, E35D, M36I, N37D, R41K, R57K, Q61E, L63V, E65D, H69K, L89MA
 CP076302432CP076302432HQ995492None   I15V, L19Q, K20R, M36I, R41K, L63V, H69K, L89M, I93LA
Kasang (2011)2328223282HM572375None  G48GRL10V, E35D, M36I, R41K, R57K, L63V, G68GR, H69K, L89MA
Ndembi (2011)AICPS107AICPS107HQ702634None   L10I, I13V, E35D, M36I, R41K, R57K, L63V, H69Q, L89MA
 AICPS435AICPS435HQ702635None   I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
 AICPS001AICPS001HQ702677None  L33FI13V, K14R, G17D, E35D, M36T, R41K, R57K, L63V, E65D, H69K, V77I, L89MA
Caron (2012)Gab052267Gab052267JN704996None   L10V, I13V, I15V, G16E, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
Dvali (2012)R060R060GQ268463None   I13V, G16E, E35D, M36I, R41K, L63V, H69K, L89M, I93LA
 R050R050GQ268456None   E35D, M36I, R41K, Q61E, L63V, I64M, H69K, L89M, I93LA
 R155R155GQ268529None   L10I, I13V, I15V, E35D, M36I, R41K, R57RK, Q61E, L63V, I64M, H69K, L89M, I93LA
 R146R146FJ456911None   L10LI, I13V, K14R, G16E, E35D, M36I, R41K, L63V, H69K, V77I, L89M, I93LA
 R017R017FJ456897None   L10I, I13V, G16GE, E35ED, M36I, R41RK, L63V, H69K, L89MA
Sigaloff (2012)KECGP053KECGP053JN628468None   L10I, I13V, K14R, E21D, E35D, M36I, N37D, R41K, R57K, L63V, H69K, L89M, L97IA
 KEKSN414KEKSN414JN628478None   L10I, K14N, G16E, E35D, M36I, P39T, R41K, I62V, L63V, H69K, L89MA
 KELKN216KELKN216JN628489None   L10V, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89MA
 KELKN261KELKN261JN628520None   L10V, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, T74S, L89MA
 KELKN262KELKN262JN628521None   I13V, G16E, K20R, E35D, M36I, R41K, L63V, H69K, K70R, L89M, I93LA
 KELKN266KELKN266JN628524None  L33FI13V, K14R, E35D, M36I, R41K, R57K, L63V, H69K, L89M, L97IA
Yang (2012)KN-96KN-96JQ616925None   T12S, I13V, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
Youngpairoj (2012)cm8bbcm8bbDQ166432None   L10I, I13V, G16E, K20I, E35D, M36I, L63V, H69K, L89MA
Avidor (2013)19941994KC184322None   L10V, I15IV, G16E, K20KR, E35D, M36I, R41K, L63V, H69K, L89M, I93LA
 12721272KC184172None   T12TA, I13V, I15V, K20KR, E35ED, M36I, N37E, R41K, K43R, Q61E, L63V, I64M, H69K, L89M, I93LA
 19831983KC184313None   E35D, M36I, R41K, L63V, H69K, L89M, I93ILA
Billong (2013)MR007MR007KF192218None   L10I, I13V, G16E, E35D, M36I, R41K, K45KR, L63V, H69HN, I72IV, L89MA
Frentz (2013)EHR-97837EHR-97837JX301143None   T12P, E35D, M36I, R41K, L63V, H69K, V77I, L89MA
Hassan (2013)RS09000886RS09000886HQ441631None   I13IV, K14KR, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93LA
 RS09000918RS09000918HQ441662None   I13V, E35D, M36I, R41K, R57K, L63V, H69K, K70KR, L89MA
 RS09000967RS09000967HQ441705None   I13V, G16E, E35D, M36I, R41K, L63V, H69K, L89M, T91V, I93LA
 RS09000970RS09000970HQ441708None   I13V, G16E, K20R, E35D, M36I, R41K, Q61H, L63V, G68E, H69K, K70R, V82VI, L89M, T91V, I93LA
 RS09000980RS09000980HQ441715None   I13IV, L19I, K20R, E35D, M36I, N37D, R41K, L63V, H69K, L89M, T91VA
 RS11000293RS11000293JQ698380None   I13V, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70KR, L89M, T91V, I93LA
 RS11000300RS11000300JQ698385None   G16E, K20R, M36I, R41K, L63V, G68E, H69K, L89M, T91V, I93LA
 RS11000320RS11000320JQ698398None   T12P, I13V, G16E, K20R, E35D, M36I, R41K, Q61E, L63V, G68E, H69K, K70R, V82I, L89M, T91V, I93LA
Kiptoo (2013)SNH017SNH017KC516935None  V32MI13V, G16E, K20R, E35D, M36I, R41K, L63V, G68E, H69K, K70R, L89M, T91V, I93LA
Pircher (2013)B1107B1107JX110294None   L10V, I13V, I15V, G16A, M36I, N37D, R41K, L63V, E65D, H69K, L89MA
Rusine (2013)494H494HKC841723None   L10I, I13V, K14R, G16E, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
  494HKC841724None   L10I, I13V, K14R, G16E, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
Sigaloff (2013)MBA046_0MBA046_0JX182017None   I3N, L10I, I13V, I15V, E35D, M36I, R41K, R57K, L63V, H69K, L89MA
Thiam (2013)MH-018MH-018JN673574None   L10I, I13V, K14R, G16E, E35D, M36I, R41K, L63V, H69K, L89MA
Van Zyl (2013)321421KC423138None   I13V, E35D, M36I, R41K, I62V, L63V, I64L, H69K, L89MA
Bartolo (2014)09AOHDP14509AOHDP145KF853769None   L10I, I13V, Q18H, L19V, E35D, M36I, R41K, L63V, H69K, L89MA
 09AOHDP13009AOHDP130KF853766None   L10I, I13V, G16GE, Q18QH, E35D, M36I, R41K, L63V, H69K, L89MA
 09AOHDP27409AOHDP274KF853838None   I13V, G16E, K20R, M36I, R41K, L63V, H69K, L89M, T91V, I93LA