Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	L63T
Rx	>= 1 PI
IncludeMixtures	No

References	8
Patients	20
Isolates	26

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Non-B Workgroup (2005)	UK1516	UK1516		PI, LPV	NA	I54L		L10I, I13V, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, T74S, V82VI, I85V, L89M	A
	IL276	IL276		IDV	81			L10I, E35D, M36I, R41K, R57K, L63T, H69R, L89M, I93L	A
	PL9728	60099	AY901076	IDV, RTV, ATV		I54V, V82A	L33I, F53L, N83D	L10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91A	A
	TK3017	TK3017		RTV	174	L90M		L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89M	A
		TK3017a		RTV	222	L90M		L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89M	A
		TK3017b		RTV	230	L90M		L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89M	A
		TK3017c		RTV	249	L90M		L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89M	A
	TK4003	TK4003		NFV	116		N83D	L10V, I13V, K14R, G16E, E35D, M36I, R41K, K45R, R57K, L63T, H69K, K70R, L89M, I93L	A
		TK4003a		NFV	215	I54V	L33I, N83D	L10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89I	A
	TK5012	TK5012		IDV	54			L10I, I13V, K14R, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89M	A
		TK5012a		IDV, LPV	152			L10I, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89M	A
		TK5012b		IDV, LPV	191			L10IV, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89M	A
	PL43110	75401		IDV	208			K20R, E35D, M36I, N37D, R41K, I62V, L63T, H69K, L89M	A
Weber (2005)	F51354	F51354	AY677444	SQV, NFV	115			L10V, I13V, K14R, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, I72T, T74TA, L89M	A
	M47502	M47502	AY677409	NFV	51	N88NS		L10I, I13V, K20KT, E35ED, M36I, R41K, L63T, I64IV, H69K, L89M	A
Baxter (2006)	48-4018	4018-30227	DQ878252	PI	NA	M46I	L10F, V11I, L24I, L33F, Q58E, T74P	T12TA, I13V, E35D, M36IV, N37D, I62V, L63T, H69K, K70R, I85V, L89M	A
	48-4153	4153-30326	DQ878387	PI	NA	M46I, I54L, L76V, I84V	L10F	I13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TS	A
	48-4186	4186-30408	DQ878420	PI	NA	I54V, V82A	L24I, L33I, Q58E, N83D	L10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93L	A
	48-4202	4202-30804	DQ878434	PI	NA			L10V, I13V, K14KR, I15V, G16E, E35D, M36I, R41K, K45R, L63T, H69K	A
	48-5021	5021-30606	DQ878555	PI	NA	I54V, V82F, I84IV, L90M	L33F, F53L	L10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89M	A
von Wyl (2007)	27	10528715	EF449796	PI	NA			I13IV, K14KR, I15IV, E35D, M36I, R41K, L63T, H69K, L89M	A
Steegen (2009)	BV114	BV114-1	EU872122	LPV	4			I13V, G16E, K20R, E35D, M36I, R41K, Q61H, L63T, G68E, H69K, K70R, V82I, L89M, T91V, I93L	A
Charpentier (2011)	32	CP 001-144		Unknown, LPV	NA			I13V, K14R, G17E, K20I, E34K, M36I, N37D, P39M, L63T, I64M, H69K, K70KR, I72T, L89M	A
	51	CP 001 2273		Unknown, LPV	NA			T12P, I13V, G16E, K20R, E35D, M36I, R41K, K55K*, L63T, E65EG, G68GE, H69KR, L89M	A
Barber (2012)	50857	50857	JQ361664	LPV		M46I, L76V, I84V		L10I, I13V, G16E, M36I, R41K, L63T, H69K, L89M	A
Jones (2012)	184144	184144	JN670673	PI	NA	M46I, I50IL, I54AV, V82A	L24I, L33F, Q58E	L10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89M	A

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