<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L63T
Rx >= 1 PI
IncludeMixtures No
References 12
Patients 25
Isolates 33
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Non-B Workgroup (2005)UK1516UK1516 PI, LPVNAI54L L10I, I13V, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, T74S, V82VI, I85V, L89MA
 IL276IL276 IDV81  L10I, E35D, M36I, R41K, R57K, L63T, H69R, L89M, I93LA
 PL972860099AY901076IDV, RTV, ATV I54V, V82AL33I, F53L, N83DL10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91AA
 TK3017TK3017 RTV174L90M L10V, I13V, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK3017a RTV222L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017b RTV230L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
  TK3017c RTV249L90M L10V, I13V, G16E, K20R, E35D, M36I, P39PS, R41K, L63T, H69K, L89MA
 TK4003TK4003 NFV116 N83DL10V, I13V, K14R, G16E, E35D, M36I, R41K, K45R, R57K, L63T, H69K, K70R, L89M, I93LA
  TK4003a NFV215I54VL33I, N83DL10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89IA
 TK5012TK5012 IDV54  L10I, I13V, K14R, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012a IDV, LPV152  L10I, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
  TK5012b IDV, LPV191  L10IV, I13V, K14KR, G16E, K20R, E35D, M36I, R41K, L63T, H69K, L89MA
 PL4311075401 IDV208  K20R, E35D, M36I, N37D, R41K, I62V, L63T, H69K, L89MA
Weber (2005)F51354F51354AY677444SQV, NFV115  L10V, I13V, K14R, G16E, K20T, E35D, M36I, R41K, R57K, L63T, H69K, I72T, T74TA, L89MA
 M47502M47502AY677409NFV51N88NS L10I, I13V, K20KT, E35ED, M36I, R41K, L63T, I64IV, H69K, L89MA
Baxter (2006)48-40184018-30227DQ878252PINAM46IL10F, V11I, L24I, L33F, Q58E, T74PT12TA, I13V, E35D, M36IV, N37D, I62V, L63T, H69K, K70R, I85V, L89MA
 48-41534153-30326DQ878387PINAM46I, I54L, L76V, I84VL10FI13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TSA
 48-41864186-30408DQ878420PINAI54V, V82AL24I, L33I, Q58E, N83DL10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93LA
 48-42024202-30804DQ878434PINA  L10V, I13V, K14KR, I15V, G16E, E35D, M36I, R41K, K45R, L63T, H69KA
 48-50215021-30606DQ878555PINAI54V, V82F, I84IV, L90ML33F, F53LL10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89MA
von Wyl (2007)2710528715EF449796PINA  I13IV, K14KR, I15IV, E35D, M36I, R41K, L63T, H69K, L89MA
Steegen (2009)BV114BV114-1EU872122LPV4  I13V, G16E, K20R, E35D, M36I, R41K, Q61H, L63T, G68E, H69K, K70R, V82I, L89M, T91V, I93LA
Charpentier (2011)32CP 001-144 Unknown, LPVNA  I13V, K14R, G17E, K20I, E34K, M36I, N37D, P39M, L63T, I64M, H69K, K70KR, I72T, L89MA
 51CP 001 2273 Unknown, LPVNA  T12P, I13V, G16E, K20R, E35D, M36I, R41K, K55K*, L63T, E65EG, G68GE, H69KR, L89MA
Charpentier (2011)CR-50CR-50FJ688256PINAM46IL10FK20I, E35D, M36I, N37D, R41K, I62IV, L63T, H69K, T74A, V77VI, I85IV, L89M, I93LA
Barber (2012)5085750857JQ361664LPV M46I, L76V, I84V L10I, I13V, G16E, M36I, R41K, L63T, H69K, L89MA
Jones (2012)184144184144JN670673PINAM46I, I50IL, I54AV, V82AL24I, L33F, Q58EL10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89MA
Inzaule (2013)472472JQ914071LPV   I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, H69K, L89MA
  472JQ914073LPV   I13V, G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, H69K, L89MA
  472JQ914066LPV, NFV   G16E, K20R, E35D, M36I, R41K, R57K, L63T, E65D, H69K, L89MA
Rawizza (2013)LM3929LM3929KF241482LPV M46I, I47V, I54V, V82AF53L, Q58EL10I, I13V, K14R, I15V, K20I, L33L_L, E35G, M36I, R41K, K55R, L63T, I64M, L89MA
 LN5329LN5329KF241490LPV   I13IMV, G17E, K20I, M36I_V, P39AS, L63T, I64L, H69K, L89MA
Grossman (2014)948948 LPV52  I13V, E35D, M36I, R41K, L63T, H69K, V77I, L89M, I93LA