<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L63S
Rx >= 1 PI
IncludeMixtures No
References 7
Patients 9
Isolates 10
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M35M35AY010399NFV M46I, L90M L10I, I13V, K14R, G16E, K20I, E35DN, M36I, I62IV, L63S, C67D, H69R, I72T, L89M, I93IMA
Non-B Workgroup (2005)TK1030TK1030 SQV, RTV, IDV146  L10I, I13V, G16E, E35D, M36I, R41K, R57K, L63S, H69K, L89MA
Weber (2005)F78596F78596AY677480IDV18  L10I, I13V, I15L, K20I, E35D, M36I, L63S, H69K, L89MA
Baxter (2006)48-12541254-30617DQ877779PINAG48VL33F, N83DL10LI, I13V, E35D, M36V, N37NS, P39T, R41K, R57K, L63S, H69K, L89MA
  1254-40601DQ877780PI, RTV, TPV>50 L33FT12A, I13V, E35D, M36IV, P39AT, R41K, R57K, L63S, H69K, L89MA
Van Zyl (2013)O7211935KC423520LPV52  T12P, I13V, I15V, G16E, E35D, M36I, R41RK, D60DE, L63S, H69K, K70R, L89IM, T91V, I93LA
Kolomeets (2014)423423_577KJ870619ATV   E35D, M36I, R41K, L63S, H69K, V77I, L89MA
 323323_458KJ870537ATV M46MIG48R, I54IFE35D, M36I, R41K, L63S, H69K, L89M, I93LA
Diaz (2015)RenG16869RenG16869KT747897PINAM46L, I54V, V82A, L90ML33IL10V, T12K, I13V, K20R, E35D, M36I, R41K, F53I, K55N, R57K, D60E, Q61N, I62V, L63S, A71T, L89I, Q92KA
 RenG15172RenG15172KT746200PINAV32I, M46I, I47V, I54M, V82A, L90ML33F, F53L, T74PL10I, I13V, G16GDE, K20R, E34A, E35D, M36I, R41K, K45KR, K55R, R57K, Q61N, L63S, C67E, I72V, V77IA