<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L63P
Rx >= 1 PI
IncludeMixtures No
References 21
Patients 41
Isolates 44
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M72M72AY010434IDV M46MI, I84V I13V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89TA
Gibb (2002)DMG102102_w51 NFV52 V32LI13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89MA
 DMG9898_w29 NFV29  I13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89MA
Vergne (2002)LV04BLV04BAJ313406IDV74  I13V, G17E, K20I, M36I, N37D, L63P, H69K, K70R, L89MA
Vergne (2003)VL00SN69HPD00SN69AJ583752IDV I84VG73SI13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, A71V, L89TA
Montes (2004)MB_patSAN01_SANC718AJ577992SQV, IDV, RTV143M46I, I84V, L90MG73S, L89VL10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69KA
Non-B Workgroup (2005)UK847bUK847bAY900783NFV, LPV   I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
 UK2149UK2149AY900859Unknown, LPVNAM46I, L76V, I84VL33I, N83DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89IA
 TK2029TK2029 IDV39  L10I, I13V, K14R, G16GE, E35D, M36I, R41K, K45R, R57K, L63P, H69K, V77I, L89MA
 TK4007TK4007 NFV178M46I I13V, E35D, M36I, R41K, R57K, L63P, H69K, A71AV, L89TA
 TK5005TK5005 SQV, IDV, RTV, NFV, LPV180G48V, I54T, V82A, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89IA
  TK5005a SQV, IDV, RTV, NFV, LPV196G48V, I54T, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IMA
 PL3403155128 IDV, NFV207M46I, I84VL89VL10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71VA
Weber (2005)F46097F46097AY677388NFV, SQV, RTV148  T4TP, I13V, K14R, Q18QH, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
Baxter (2006)12-21202120-30715DQ876783PINAM46I, I47V, L90ML10F, L33I, F53L, G73GS, N88G, L89VI13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71IA
  2120-40510DQ876754PI, RTV, TPV>43M46I, I47V, L90ML10F, L33I, F53L, G73S, N88G, L89VI13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71IA
 48-30453045-30317DQ877957PINAG48V, I54S, V82AL33F, Q58E, N83DL10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TSA
 48-33163316-30818DQ878217PINAI54A, V82F L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89MA
 48-50055005-30422DQ878538PINAI54IATV, V82VA, L90LML33LFL10LI, I13V, K14KR, L19LI, K20KR, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89IMA
 48-50105010-30820DQ878543PINAM46MIL, I54V, V82AQ58EL10I, I13V, K20KR, E35D, M36I, N37ND, R41K, I62V, L63P, A71TA
 48-50355035-30421DQ878561PINA  T12P, I13V, K14R, E35D, M36I, R41K, K45R, R57K, L63P, H69K, K70R, L89MA
 48-80538053-30818DQ879078PINAM46L, G48V, I54S, V82AL33I, F53LL10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89IA
Laurent (2006)CK22-3503CM2-35AM279456IDV74I54IV, V82AL33LIL10I, I13V, E35D, M36I, R41K, K45R, L63P, H69K, L89TA
Seyler (2007)547CS_547 NFV268 G48GR, V82VDI13V, K14R, G16GR, K20I, M36IT, R41K, L63P, H69K, L89MA
Rosen-Zvi (2008)3908p39-3 RTV, IDV, LPV, ATV479  E35D, M36I, R41K, K45R, L63P, H69K, A71T, L89MA
Koyalta (2009)17TCHAD-17FJ688177IDV26M46I, I84V L10I, I13V, K14R, I15V, K20I, M36I, R41K, R57K, L63P, I66F, H69N, I72V, L89IA
Steegen (2009)BV223BV223-1EU872135LPV4  I13V, E35D, M36I, P39Q, R41K, L63P, H69K, L89MA
Dau (2010)11741A11741AGU582052PINAN88SL10F, L89VI13V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, T74SA
Hamkar (2010)17Ir-HIV-DR-17GU724820PINA L23IQ2H, T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93F, T96PA
 30Ir-HIV-DR-30GU724833PINA  T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93LA
Dvali (2012)R005R005FJ456894NFV M46MI, N88NSL23LI, K43KTK14R, I15IV, K20T, E35D, M36I, N37D, R41K, L63P, H69K, A71AV, L89M, I93LA
El Annaz (2012)14291429.PRJN185237PINA  L10V, I13V, K14R, I15V, M36I, L63P, H69K, L89MA
 18771877.PRJN185240PINA  L10V, I13V, I15V, M36I, L63P, H69K, L89MA
Jones (2012)182090182090JN670599PINAM46I, I54V, L76VL89VK20P, E35N, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92KA
 199883199883JN671186PINAM46I, I54V, V82A, L90MN88DL10I, I13V, I15V, L19I, K20I, E35D, M36I, N37K, R41K, K45R, K55R, R57K, Q61N, L63P, C67F, A71T, I72EA
Kouri (2012)CU1315-09CU1315-09JQ585290PINAI54V, L90MF53L, L89VI13V, K14R, K20I, E35D, M36I, N37D, R41K, K45R, L63P, C67CY, H69K, A71IA
 CU1908-09CU1908-09JQ585320PINAM46I, I54V, V82F, L90ML33F, T74PK20I, E35N, M36I, R41K, K43R, F53Y, R57K, I62V, L63P, H69K, I85V, R87RK, L89MA
 CU2007-09CU2007-09JQ585330PINAM46I, I54V, V82A, I84VL24I, L33FL10I, T12S, G16A, L19I, K20V, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74S, L89M, I93LA
 CU1737-09CU1737-09JQ585309PINAM46MI, I54V, L76V, V82AL10F, L24I, L33FI13V, N37S, R41K, Q61QH, L63P, H69K, A71V, L89M, I93LA
 CU1124-09CU1124-09JQ585275PINAM46MI, I54V, L76V, V82AL10F, L24I, L33FI13V, N37S, R41K, L63P, H69K, A71V, L89M, I93LA
Inzaule (2013)410410JQ914067LPV   I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
Grossman (2014)609609 LPV292M46I, I54V, V82A, L90MG73GS, N83D, L89VL10I, V11L, I13AV, K20R, A22V, E35N, M36I, N37D, R41K, K55R, R57RK, I62V, L63P, H69K, A71IV, T91S, I93LA
 14601460KC184186LPV52  I13IV, E35D, M36I, R41K, Q61E, L63P, H69K, V77I, L89M, I93LA
 20352035KC184345LPV52  L10V, E35D, M36I, R41N, L63P, H69K, K70R, L89M, I93ILA