<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation L63P
Rx >= 1 PI
IncludeMixtures No
References 27
Patients 62
Isolates 66
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M72M72AY010434IDV M46MI, I84V I13V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89TA
Gibb (2002)DMG102102_w51 NFV52 V32LI13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89MA
 DMG9898_w29 NFV29  I13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89MA
Vergne (2003)VL00SN69HPD00SN69AJ583752IDV I84VG73SI13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, A71V, L89TA
Montes (2004)MB_patSAN01_SANC718AJ577992SQV, IDV, RTV143M46I, I84V, L90MG73S, L89VL10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69KA
 MB_patMAK01_MAK707AJ577938SQV, RTV, NFV182I54V, I84V, L90MV32G, F53LL10I, I13V, K14R, G17E, K20I, E35D, M36I, R41K, L63P, H69K, T74A, L89MA
Chantratita (2005)14-010214-0102DQ130472PINAM46LG48R, N83D, L89VW6R, I13V, L33V, E35D, M36V, N37D, R41K, K55R, I62V, L63P, H69KA
 G563G563DQ130136PINAD30N, M46IN88DW6R, L10V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, I93LA
 G589G589DQ130152PINA  L10V, I13V, G16A, L19M, K20I, E35N, M36I, N37D, R41K, D60E, Q61E, L63P, H69K, L89M, I93LA
 NP304NP304DQ130384PINAG48V, I54T, V82A L10V, T12P, I13V, G16A, K20I, E35N, M36I, R41K, R57K, L63P, H69K, T74S, L89MA
Non-B Workgroup (2005)UK847bUK847bAY900783NFV, LPV   I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
 UK2149UK2149AY900859Unknown, LPVNAM46I, L76V, I84VL33I, N83DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89IA
 TK1014TK1014 RTV, SQV, NFV, IDV246M46I, I84IVL24LIL10LV, I13V, K20I, E35D, M36I, R41K, L63P, H69K, T74S, T80TA, V82X, L89IMA
 TK2029TK2029 IDV39  L10I, I13V, K14R, G16GE, E35D, M36I, R41K, K45R, R57K, L63P, H69K, V77I, L89MA
 TK4007TK4007 NFV178M46I I13V, E35D, M36I, R41K, R57K, L63P, H69K, A71AV, L89TA
 TK4010TK4010 SQV, RTV, NFV54L90M I13V, I15V, K20T, E35D, M36I, R41K, R57K, L63P, H69K, V77I, L89MA
 TK5005TK5005 SQV, IDV, RTV, NFV, LPV180G48V, I54T, V82A, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89IA
  TK5005a SQV, IDV, RTV, NFV, LPV196G48V, I54T, L90M L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IMA
 PL3403155128 IDV, NFV207M46I, I84VL89VL10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71VA
Weber (2005)F46097F46097AY677388NFV, SQV, RTV148  T4TP, I13V, K14R, Q18QH, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
Baxter (2006)12-21202120-30715DQ876783PINAM46I, I47V, L90ML10F, L33I, F53L, G73GS, N88G, L89VI13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71IA
  2120-40510DQ876754PI, RTV, TPV>43M46I, I47V, L90ML10F, L33I, F53L, G73S, N88G, L89VI13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71IA
 48-14321432-30818DQ877822PINAM46I, I54V, L76V, V82TL24IL10I, I13A, K20I, E35D, M36I, R41K, Q61H, L63P, H69K, T74S, L89IA
 48-30453045-30317DQ877957PINAG48V, I54S, V82AL33F, Q58E, N83DL10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TSA
 48-32933293-30722DQ878198PINAM46I, I54V, L76V, V82A, L90MV11IL10I, T12E, I13V, I15V, K20I, E35N, M36I, N37D, R41K, I62V, L63P, H69K, K70KR, A71V, T74S, L89I, T91SA
 48-33163316-30818DQ878217PINAI54A, V82F L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89MA
 48-33333333-30929DQ878227PINAM46I, I47V, I54V, I84VL33F, G73SL10V, I13V, I15V, K20T, E35D, M36I, P39S, R41K, Q61D, I62V, L63P, I66F, H69K, T74S, L89TA
 48-50055005-30422DQ878538PINAI54IATV, V82VA, L90LML33LFL10LI, I13V, K14KR, L19LI, K20KR, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89IMA
 48-50355035-30421DQ878561PINA  T12P, I13V, K14R, E35D, M36I, R41K, K45R, R57K, L63P, H69K, K70R, L89MA
 48-50745074-30807DQ878584PINAG48V, I54S, V82A, L90MK43TL10I, I13V, K20I, E34K, E35D, M36I, N37D, R41K, I62V, L63P, H69K, A71V, T74S, L89IA
 48-50775077-30903DQ878587PINAM46L, I54V, V82AL24I, L33F, F53L, T74PL10I, I13V, L19I, K20R, E35D, M36I, N37D, Q61R, L63P, H69K, L89MA
 48-80538053-30818DQ879078PINAM46L, G48V, I54S, V82AL33I, F53LL10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89IA
Laurent (2006)CK22-3503CM2-35AM279456IDV74I54IV, V82AL33LIL10I, I13V, E35D, M36I, R41K, K45R, L63P, H69K, L89TA
Rosen-Zvi (2008)3908p39-3 RTV, IDV, LPV, ATV479  E35D, M36I, R41K, K45R, L63P, H69K, A71T, L89MA
 4600p46-1 RTV, SQV, NFV, APV141M46MIL, I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89IA
Dau (2010)11741A11741AGU582052PINAN88SL10F, L89VI13V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, T74SA
Knops (2010)ID1585ID1585-GT1GU271168SQV, NFV, RTV, APV I54V, V82M, I84V, L90ML33F, Q58EL10V, T12V, I13IV, K14KR, I15V, K20R, E35D, M36I, N37E, R41K, R57K, L63P, H69K, L89IA
  ID1585-GT2GU271169SQV, NFV, RTV, APV, LPV64I54V, L76V, V82M, L90ML33F, Q58E, G73S, L89VL10V, T12V, I13V, I15V, K20R, E35D, M36I, N37E, R57K, I62IV, L63P, H69KA
Charpentier (2011)4CP001-045 Unknown, IDVNAL90ML33IL10V, I13V, L19F, K20T, E35D, M36I, R41K, R57K, L63P, H69K, T74S, L89IA
Dvali (2012)R005R005FJ456894NFV M46MI, N88NSL23LI, K43KTK14R, I15IV, K20T, E35D, M36I, N37D, R41K, L63P, H69K, A71AV, L89M, I93LA
El Annaz (2012)18771877.PRJN185240PINA  L10V, I13V, I15V, M36I, L63P, H69K, L89MA
Kouri (2012)CU1908-09CU1908-09JQ585320PINAM46I, I54V, V82F, L90ML33F, T74PK20I, E35N, M36I, R41K, K43R, F53Y, R57K, I62V, L63P, H69K, I85V, R87RK, L89MA
Inzaule (2013)410410JQ914067LPV   I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
Agyingi (2014)LB085LB085KF576442PINA  I15V, E35D, M36I, R41K, K45R, R57K, D60E, I62V, L63P, H69K, I72V, L89MA
Grossman (2014)14601460KC184186LPV52  I13IV, E35D, M36I, R41K, Q61E, L63P, H69K, V77I, L89M, I93LA
 20352035KC184345LPV52  L10V, E35D, M36I, R41N, L63P, H69K, K70R, L89M, I93ILA
Kolomeets (2014)162162_192KJ870333LPV   I13V, E35D, M36I, R41K, L63P, H69K, V77I, L89MA
 205205_247KJ870373ATV   I13V, I15V, E35D, M36I, R41K, L63P, H69K, L89M, I93LA
 410410_599KJ870631LPV   K14R, G16E, E35D, M36I, R41K, I62V, L63P, H69K, V77I, L89M, I93LA
 277277_508KJ870572LPV   E35D, M36I, R41K, Q61E, L63P, C67F, H69K, V77I, L89M, I93LA
 4545_625KJ870655NFV   R41K, R57RK, L63P, I64L, H69K, V77I, L89MA
 340340_517KJ870578ATV   I13IV, K14R, G16GA, E35D, M36I, R41K, R57K, L63P, H69K, V77I, L89MA
 294294_558KJ870605SQV   K14KR, M36I, R41K, L63P, H69K, L89M, I93LA
 415415_634KJ870660APV   I13V, E35D, M36I, R41K, L63P, G68E, H69K, L89MA
 262262_233KJ870366LPV   I13V, I15V, M36I, R41K, L63P, H69K, L89IM, I93LA
Nerrienet (2014)R0712188R0712188JN675747LPV M46I, G48V, I54V, L76V, V82TL89VL10R, I13A, K14R, K20I, E35D, M36I, N37D, R41K, K55N, D60E, L63P, H69K, K70R, A71V, T91A, Q92KA
 U0407179U0407179JN675767LPV M46I, I84V, L90ML10F, L33F, F53L, Q58E, G73GS, N88G, L89VI13V, K20T, E35D, M36I, R41K, K55R, R57K, L63P, I66IF, H69K, A71VA
 U0907156U0907156JN675771LPV V32I, M46I, I47V, I54M, L90ML33F, Q58E, N83DL10V, I13V, G16A, M36I, N37D, R41K, K55R, D60N, L63P, I64V, H69K, K70R, A71IV, G73GD, L89IA
Diaz (2015)RenG16380RenG16380KT747408PINAM46I, I54V, L76V, V82A L10I, I13V, I15V, G16A, L19IV, K20I, E21Q, E35D, M36I, N37E, R41K, I62V, L63P, I64V, H69K, A71T, T74TSA
Jenabian (2015)DR09DR09KF735820PINA  I13V, E35N, M36I, N37D, R41K, L63P, H69K, V77I, L89MA
 DR05DR05KF735816PINA  I13V, K20R, E35N, M36I, N37D, R41K, K43R, R57K, L63P, H69K, K70R, L89MA
Laga (2015)AM048AM048KM023157NFV   I13V, K14R, E35D_IN, M36L, R41K, L63P, H69K, V77I, L89M, I93LA
Abdellaziz (2016)1505115051KT339029PINAV32I, M46I, V82AL10F, K43T, L89VI13V, K20M, M36I, L63P, H69K, A71VA
Inzaule (2016)1.04371.0437HM164128NFV   L19I, E35D, M36I, N37D, R41K, R57K, L63P, H69K, L89M, F99FLA
 1.0411.041HM164127NFV   T12TS, I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89MA
Ndahimana Jd Riedel (2016)21652165KT982498LPV M46I, I54V, V82AL10F, L33FI13V, E35D, M36I, N37D, P39Q, R41K, K45I, R57K, D60NS, Q61E, L63P, H69Q, L89I, T91SA