Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	L63P
Rx	>= 1 PI
IncludeMixtures	No

References	16
Patients	29
Isolates	32

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Yahi (2001)	NY_M72	M72	AY010434	IDV		M46MI, I84V		I13V, K20I, E35D, M36I, R41K, L63P, H69K, A71V, L89T	A
Gibb (2002)	DMG102	102_w51		NFV	52		V32L	I13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89M	A
	DMG98	98_w29		NFV	29			I13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89M	A
Vergne (2002)	LV04B	LV04B	AJ313406	IDV	74			I13V, G17E, K20I, M36I, N37D, L63P, H69K, K70R, L89M	A
Vergne (2003)	VL00SN69HPD	00SN69	AJ583752	IDV		I84V	G73S	I13V, E35D, M36I, R41K, K45R, R57K, L63P, H69K, A71V, L89T	A
Montes (2004)	MB_patSAN	01_SANC718	AJ577992	SQV, IDV, RTV	143	M46I, I84V, L90M	G73S, L89V	L10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69K	A
Non-B Workgroup (2005)	UK847b	UK847b	AY900783	NFV, LPV				I13V, K14R, E35D, M36I, R41K, R57K, L63P, H69K, L89M	A
	UK2149	UK2149	AY900859	Unknown, LPV	NA	M46I, L76V, I84V	L33I, N83D	L10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89I	A
	TK2029	TK2029		IDV	39			L10I, I13V, K14R, G16GE, E35D, M36I, R41K, K45R, R57K, L63P, H69K, V77I, L89M	A
	TK4007	TK4007		NFV	178	M46I		I13V, E35D, M36I, R41K, R57K, L63P, H69K, A71AV, L89T	A
	TK5005	TK5005		SQV, IDV, RTV, NFV, LPV	180	G48V, I54T, V82A, L90M		L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71V, L89I	A
		TK5005a		SQV, IDV, RTV, NFV, LPV	196	G48V, I54T, L90M		L10I, I13V, K14R, G17D, K20R, E34N, E35D, M36I, R41K, R57K, D60E, I62V, L63P, H69K, A71IV, L89I, I93IM	A
	PL34031	55128		IDV, NFV	207	M46I, I84V	L89V	L10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71V	A
Weber (2005)	F46097	F46097	AY677388	NFV, SQV, RTV	148			T4TP, I13V, K14R, Q18QH, E35D, M36I, R41K, R57K, L63P, H69K, L89M	A
Baxter (2006)	12-2120	2120-30715	DQ876783	PI	NA	M46I, I47V, L90M	L10F, L33I, F53L, G73GS, N88G, L89V	I13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71I	A
		2120-40510	DQ876754	PI, RTV, TPV	>43	M46I, I47V, L90M	L10F, L33I, F53L, G73S, N88G, L89V	I13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71I	A
	48-3045	3045-30317	DQ877957	PI	NA	G48V, I54S, V82A	L33F, Q58E, N83D	L10V, I13V, K14R, I15V, M36L, R41RK, D60DE, I62IV, L63P, H69K, I85V, L89I, T91TS	A
	48-3316	3316-30818	DQ878217	PI	NA	I54A, V82F		L10I, T12TK, I13V, G16A, L19LV, K20I, E35N, M36I, R41K, D60E, L63P, H69K, T74S, V77I, L89M	A
	48-5005	5005-30422	DQ878538	PI	NA	I54IATV, V82VA, L90LM	L33LF	L10LI, I13V, K14KR, L19LI, K20KR, E35D, M36I, R41K, K45R, R57K, L63P, H69K, L89IM	A
	48-5010	5010-30820	DQ878543	PI	NA	M46MIL, I54V, V82A	Q58E	L10I, I13V, K20KR, E35D, M36I, N37ND, R41K, I62V, L63P, A71T	A
	48-5035	5035-30421	DQ878561	PI	NA			T12P, I13V, K14R, E35D, M36I, R41K, K45R, R57K, L63P, H69K, K70R, L89M	A
	48-8053	8053-30818	DQ879078	PI	NA	M46L, G48V, I54S, V82A	L33I, F53L	L10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89I	A
Laurent (2006)	CK22-35	03CM2-35	AM279456	IDV	74	I54IV, V82A	L33LI	L10I, I13V, E35D, M36I, R41K, K45R, L63P, H69K, L89T	A
Seyler (2007)	547	CS_547		NFV	268		G48GR, V82VD	I13V, K14R, G16GR, K20I, M36IT, R41K, L63P, H69K, L89M	A
Rosen-Zvi (2008)	39	08p39-3		RTV, IDV, LPV, ATV	479			E35D, M36I, R41K, K45R, L63P, H69K, A71T, L89M	A
Koyalta (2009)	17	TCHAD-17	FJ688177	IDV	26	M46I, I84V		L10I, I13V, K14R, I15V, K20I, M36I, R41K, R57K, L63P, I66F, H69N, I72V, L89I	A
Steegen (2009)	BV223	BV223-1	EU872135	LPV	4			I13V, E35D, M36I, P39Q, R41K, L63P, H69K, L89M	A
Dau (2010)	11741A	11741A	GU582052	PI	NA	N88S	L10F, L89V	I13V, K20T, E35D, M36I, R41K, I62V, L63P, H69K, T74S	A
Hamkar (2010)	17	Ir-HIV-DR-17	GU724820	PI	NA		L23I	Q2H, T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93F, T96P	A
	30	Ir-HIV-DR-30	GU724833	PI	NA			T12P, K14R, K20R, E35D, M36I, R41K, L63P, H69K, L89M, I93L	A
Jones (2012)	182090	182090	JN670599	PI	NA	M46I, I54V, L76V	L89V	K20P, E35N, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92K	A
	199883	199883	JN671186	PI	NA	M46I, I54V, V82A, L90M	N88D	L10I, I13V, I15V, L19I, K20I, E35D, M36I, N37K, R41K, K45R, K55R, R57K, Q61N, L63P, C67F, A71T, I72E	A

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