Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	L63I
Rx	PI-naive
IncludeMixtures	No

References	20
Patients	22
Isolates	22

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	OtherMut	Subtype
Becker-Pergola (2000)	194.793	BPG194-793	AF177354	None	I13V, K14KR, E35D, M36I, R41K, R57K, L63I, H69K, L89M	A
Eshleman (2001)	SE440	SE440	AF388079	None	L10I, I13V, E35D, M36I, R41K, R57K, L63I, H69K, L89M	A
Shafer (2003)	A384_2774	2774a	EF548532	None	P9X, E35D, M36I, R41K, R57K, I62V, L63I, H69K, L89IM, F99X	A
Eshleman (2004)	ESH_Pat141	ESH445	AY435289	None	L10I, I13V, K14R, G16GA, E35D, M36I, R41K, R57K, L63I, C67CG, H69K, L89M	A
Eshleman (2004)	194_793	194_793	AY444183	None	I13V, K14KR, E35D, M36I, R41K, R57K, L63I, H69K, L89M	A
Carr (2005)	03UZ030	03UZ030	AY845759	None	I13V, E35D, M36I, R41K, L63I, H69K, L89M, I93L	A
Marechal (2006)	JF_071	JF_071	DQ443675	None	L10I, L19I, E35D, M36I, R41K, K45KR, G51GV, R57K, L63I, I66IM, H69K, I72IM, L89M	A
Baker (2007)	P0079	P0079-160305	EF186140	None	L10V, I13V, K14R, I15V, G16E, E35D, M36I, R41K, R57K, L63I, H69K, L89M	A
Church (2008)	335346R	335346R	EU380722	None	L10I, I13V, E35D, M36I, R41K, R57K, L63I, H69K, L89M	A
Ndembi (2008)	IAEM022	IAEM022	EU306759	None	I13V, K14KR, E35D, M36I, N37D, R41K, R57K, L63I, H69K, L89M	A
Somi (2008)	BG-05-438	BG-05-438	JQ616946	None	I13V, I15V, E35D, M36I, L38C, R41K, R57K, L63I, H69K, L89M	A
Thomson (2009)	SP_B_033	RU_SP_B_033	FJ009798	None	L10I, K14R, E35D, M36I, N37D, R41K, L63I, H69K, L89M, I93L	A
Ndembi (2010)	13354D_P1	13354	GQ409556	None	I13V, I15V, L19I, E35D, M36I, R41K, R57K, I62V, L63I, I64M, H69K, K70R, L89M	A
Sanders-Buell (2010)	051H	051H	GQ477444	None	I13V, L19Q, K20R, E35D, M36I, R41K, R57K, L63I, H69K, L89M	A
	046H	046H	GQ477447	None	I13V, L19Q, K20R, E35D, M36I, R41K, R57K, I62V, L63I, H69K, L89M	A
	027H	027H	GQ477451	None	I13V, L19Q, K20R, E35D, M36I, R41K, R57K, I62V, L63I, H69K, L89M	A
Towler (2010)	439552-J	439552-J	HM037829	None	L10I, I13V, E35D, M36I, R41K, R57K, L63I, H69K, L89M	A
Hamers (2011)	CP076303121	CP076303121	HQ995296	None	L10V, I13V, I15V, E35D, M36I, N37D, R41K, R57K, D60E, L63I, H69K, L89M	A
Manasa (2011)	1005066	1005066	JN665013	None	I13V, I15V, E35D, M36I, R41K, K45R, L63I, H69K, L89M	A
Ndembi (2011)	AICPS035	AICPS035	HQ702682	None	L10M, I13V, K14R, I15V, G16E, E35D, M36I, R41K, R57K, L63I, H69K, L89M	A
Hassan (2012)	RS09000913	RS09000913	HQ441658	None	I13V, K14R, E35D, M36I, R41K, R57K, I62V, L63I, I64M, H69K, L89M	A
Sigaloff (2012)	KELKN265	KELKN265	JN628523	None	I13V, K20R, E35D, M36I, N37D, R41K, K45R, R57K, L63I, H69K, L89M	A

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