Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	L63A
Rx	PI-naive
IncludeMixtures	No

References	37
Patients	76
Isolates	77

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Holguin (2000)	AHHC17	HolgHC17	AF188349	None		L10I, E35D, M36I, R41K, L63A, C67D, H69K, L89M	A
Si-Mohamed (2000)	AS_FOG	AS_FOG	AF199299	None		I13V, G16E, E35D, M36I, R41K, L63A, H69K, V77I, L89M	A
Gibb (2002)	DMG5	5_w0		None		I13V, E35D, M36I, R41K, R57K, L63A, I64M, H69K, L89M	A
Servais (2004)	SJ_Pat8	SJKLM015	AJ412942	None		K14R, E35D, M36I, R41K, R57K, L63A, H69K, L89M	A
Vessiere (2006)	AV_M4606N	AV_M4606N	DQ297201	None		I13V, G16E, G17DE, K20KR, E35D, M36L, R41K, L63A, H69K, K70R, L89M, T91V, I93L	A
Vidal (2006)	NV_KSFE110	02.KSFE110	AM041005	None		I13V, G16E, K20R, E35D, M36I, P39S, R41K, D60E, I62V, L63A, H69K, L89M	A
	NV_KSS004	02.KSS004	AM041045	None		I13V, G16E, K20R, E35D, M36I, R41K, L63A, I64V, H69K, T91V, I93L	A
Visawapoka (2006)	KNH1239	KNH1239	AY945739	None		I13V, G16E, E35D, M36I, R41K, L63A, H69K, K70R, L89M, T91V	A
Dilernia (2007)	F038	F038	EF120099	None		I13V, G16E, K20R, E35D, M36I, N37D, R41K, L63A, G68GE, H69KR, L89M, T91V, I93L	A
Galluzzo (2007)	24080	RW_24080	JQ220007	None		I13V, E35D, M36I, R41K, R57K, L63A, H69K, L89M	A
Vidal (2007)	U1524	02BU.U1524	AM260313	None		I13V, E35D, M36I, R41K, R57K, L63A, H69K, K70R, V77I, L89M	A
Holguin (2008)	SP1B-118006	SP1B-118006	EU362920	None		L10I, I13V, G16E, E35D, M36I, R41K, L63A, H69K, L89M, T91V	A
Ndembi (2008)	IAEM067	IAEM067	EU306786	None		I13V, E35D, M36I, N37I, R41K, R57K, L63A, H69K, L89M	A
Nyombi (2008)	TBK030	TBK030	EU251733	None	V11VI	L10I, I13V, K14R, E35D, M36I, R41K, R57K, I62V, L63A, H69K, L89M	A
	TMS002	TMS002	EU251783	None		I13V, K14R, E35D, M36I, R41K, R57K, L63A, H69K, K70R, L89M	A
	TMS016	TMS016	EU251795	None		I13V, E35D, M36I, R41K, R57K, I62V, L63A, I64L, H69K, L89M	A
	TMS108	TMS108	EU251810	None		I13V, K14R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	TMS115	TMS115	EU251815	None		I13V, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	TMS127	TMS127	EU251825	None		I13V, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	TMS343	TMS343	EU251877	None		L10V, I13V, K14R, G16E, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
Somi (2008)	KW-05-010	KW-05-010	JQ616960	None		I13V, K14R, E35D, M36I, R41K, M46X, R57K, L63A, I64M, H69K, L89M	A
Aghokeng (2009)	AV_0274	AV_0274	GU191655	None		I15V, G16E, E35D, M36I, R41K, R57K, Q61QH, L63A, E65ED	A
Bartolo (2009)	HAB87	01AOHAB87	EU068220	None		L10V, I13V, G16E, E35D, M36I, R41K, I62V, L63A, H69K, L89M	A
Cuevas (2009)	X2711_1	X2711_1	GU326181	None		K14R, G16E, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M, I93L	A
Vercauteren (2009)	pt2176	190217330	GQ398848	None		T12I, I13V, K14R, G16GE, E35D, M36I, R41K, R57K, L63A, H69K, L89M	A
	pt1759	2825916426	GQ399265	None		Q7QE, I13V, K14R, I15V, K20R, E35D, M36I, N37D, R57K, L63A, H69K, K70R, L89M	A
	pt1688	3214946766	GQ399336	None		I13V, K14KR, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	pt1445	4576341374	GQ399579	None		I13V, K14R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	pt1440	4619944919	GQ399584	None		I13V, L19I, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	pt1412	4784320538	GQ399612	None		L10LM, I13V, I15IL, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	pt1354	5089956118	GQ399670	None		I13V, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M, L97*	A
	pt1332	5234413600	GQ399692	None		I13V, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M, I93L	A
	pt1106	6564519905	GQ399918	None		L10I, I13V, K14R, G16E, K20R, E35D, M36I, N37D, R41K, K45R, R57K, L63A, H69K, K70R, L89M	A
	pt877	7940838415	GQ400147	None		I13V, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M, N98NI	A
	pt759	8595222384	GQ400265	None		I13V, L19I, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	pt575	9510400631	GQ400449	None		L10I, T12A, I13V, I15K, G16E, K20R, E21D, E35D, M36I, L63A, C67CY, H69K, K70R, V82I, L89M	A
Yebra (2009)	SP11-322971	SP11-322971	EU255384	None		I13V, E35D, M36I, R41K, K45KR, L63A, H69K, L89M	A
Djoko (2010)	677	CD2038	FR666677	None		I13V, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	678	CD2656	FR666678	None		I13V, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
Mosha (2010)	S47Pol	S47Pol	JQ071479	None		I13V, K14QR, I15V, E35D, M36I, R41K, R57K, L63A, H69K, K70KR, L89M	A
Ndembi (2010)	16079D_P1	16079	GQ409581	None		I13V, K14R, E35D, M36I, R41K, R57K, L63A, H69K, L89M	A
Soares (2010)	CM04_094	CM04_094	GU366134	None		L10V, I13V, K14R, G16E, K20R, E35D, M36I, R41K, K45R, L63A, H69K, L89M	A
Towler (2010)	1	320024-A	HM037810	None		T12S, I13V, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
		393250-S	HM037884	None		L10V, I13V, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	337314-Y	337314-Y	HM037815	None		I13V, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
Yang (2010)	2010693452	2010693452	JQ616891	None	V11I	L10I, T12K, I13V, L19V, M36I, N37D, R41K, I62V, L63A, H69Q, V82I, L89M	A
Charpentier (2011)	121	CP 001 724		None		I15IV, K20R, E35D, M36I, N37D, R41K, R57K, Y59YH, L63A, H69K, K70R, L89M	A
Hamers (2011)	CP076301700	CP076301700	HQ993695	None		L10I, I13V, K14R, G16E, E35D, M36I, N37D, R57K, L63A, H69K, L89M	A
	CP076301735	CP076301735	HQ993725	None		E35D, M36I, R41K, R57K, L63A, H69K, L89M	A
	CP076302168	CP076302168	HQ994520	None		K14R, E35D, M36I, R41K, I62IV, L63A, E65D, H69K, L89M	A
	CP076300836	CP076300836	HQ994955	None		I13V, E35D, M36I, R57K, L63A, H69K, L89M	A
	CP076300859	CP076300859	HQ995122	None		I13V, E35D, M36I, R41K, R57K, L63A, H69K, L89M	A
	CP076301992	CP076301992	HQ995178	None		I13V, E35D, M36I, R41K, K45R, R57K, L63A, H69K, I72V, L89M	A
	CP076302069	CP076302069	HQ995208	None		L10I, I13V, E35D, M36I, R41K, K45KR, R57K, L63A, H69K, L89M	A
	CP076303090	CP076303090	HQ995267	None		L10V, I13V, E35D, M36I, R41K, K43R, R57K, L63A, H69K, L89M	A
	CP076301890	CP076301890	HQ995369	None		L10I, I13V, G16E, E35D, M36I, R41K, R57K, L63A, H69K, K70R, L89M	A
	CP076301930	CP076301930	HQ995398	None		I13V, K14R, I15V, K20I, E35D, M36I, R41K, L63A, H69K, V82VI, L89M	A
	CP076301955	CP076301955	HQ995420	None		I13V, K14R, K20R, E35D, M36I, N37E, R41K, K45R, R57K, L63A, H69K, L89M	A
Kasang (2011)	32639	32639	HM572369	None		I13V, K14R, E35D, M36I, R41K, R57K, L63A, H69K, L89M	A
	14496	14496	HM572374	None		L10I, I13V, L19LQ, E35D, M36I, R41K, K45R, R57K, L63A, H69Q, N83NS, L89IM	A
Ndembi (2011)	NTCPS716	NTCPS716	HQ702631	None		I13V, K14R, K20I, E35D, M36I, N37S, R41K, L63A, H69K, K70Q, L89M	A
	AICPS005	AICPS005	HQ702676	None		I13V, I15V, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
	UGNTC737	UGNTC737	HQ702685	None		I13V, E35D, M36I, R41K, R57K, L63A, H69K, K70R, L89M	A
Caron (2012)	Gab014268	Gab014268	HQ541900	None		I13V, E35D, M36I, R41K, K45R, L63A, H69K, L89M	A
De Gascun (2012)	IRL41912	IRL41912	JN622360	None		I13V, K14R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
Hassan (2012)	RS11000252	RS11000252	JQ698352	None		L10I, I13V, K20R, E35D, M36I, N37D, R41K, D60E, L63A, C67Y, H69K, L89M	A
	RS11000290	RS11000290	JQ698377	None		I13V, G16E, E35D, M36I, R41K, L63A, H69K, K70R, L89M, T91V	A
	RS11000349	RS11000349	JQ698420	None		I13V, K14KR, G16E, K20R, E35D, M36I, R41K, I62V, L63A, G68E, H69K, K70R, L89M, T91V, I93L	A
Sigaloff (2012)	KEKSN410	KEKSN410	JN628475	None		I13V, I15V, G16E, K20R, M36I, R41K, L63A, G68E, H69K, K70R, L89M, T91V, I93L	A
	KEKSN413	KEKSN413	JN628477	None		I13V, K14R, I15V, K20R, E35D, M36I, R41K, K45Q, R57K, I62V, L63A, E65D, H69K, L89M, L97V	A
	KELKN241	KELKN241	JN628507	None		I13V, R41K, L63A, H69K, V82I, L89I	A
	KELKN250	KELKN250	JN628513	None		K14R, I15V, G16A, L19I, E35N, M36V, R41K, R57K, L63A, H69K, L89M	A
Ssemwanga (2012)	8627HR	8627HR	JF800230	None		I13V, G16E, K20R, E35D, M36I, R41K, K45R, R57K, L63A, H69K, L89M	A
Alencar (2013)	SP2-0011	SP2-0011	JQ237966	None		L10I, I13V, E35D, M36I, R41K, K45R, L63A, H69Q, L89M	A
Frentz (2013)	EHR-11577	EHR-11577	JX299726	None		I13V, E35D, M36I, R57K, I62V, L63A, H69K, I72V, T74S, L89M	A
	EHR-50613	EHR-50613	JX300382	None		I13V, E35D, M36I, N37D, R41K, R57K, L63A, H69K, L89M	A
Hawke (2013)	2618286 H	2618286 H	KC238092	None		L10V, I13V, E35D, M36I, N37D, R41K, R57K, D60E, L63A, C67Y, H69K, L89M	A

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