Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	I54V
Rx	>= 1 PI
IncludeMixtures	No

References	8
Patients	21
Isolates	21

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	Wks	PIMajorDRMs	PIMinorDRMs	OtherMut	Subtype
Yahi (2001)	NY_M29	M29	AY010392	IDV		M46I, I54V, V82F		L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89I	A
Gomez-Carrillo (2004)	103396	103396	AY365678	PI	NA	I54V		I13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, I66F, G68E, H69R, L89M, T91V	A
Non-B Workgroup (2005)	PL9728	60099	AY901076	IDV, RTV, ATV		I54V, V82A	L33I, F53L, N83D	L10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91A	A
	TK2012	TK2012		RTV, IDV, SQV	186	I54V, L90M		L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89I	A
	TK4003	TK4003a		NFV	215	I54V	L33I, N83D	L10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89I	A
Weber (2005)	M41971	M41971	AY677401	IDV, NFV, LPV	181	I54V, V82A	L10F, L33I	T4TS, I13V, G16E, L19LI, K20R, E35D, M36I, N37D, R41K, K45V, K55T, R57K, L63H, H69K, K70R, L89M, T91TS	A
	89M2626	89M2626	AY677414	SQV, NFV, RTV	261	I54V, L90M	F53L, L89V	L10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74S	A
Baxter (2006)	12-2024	2024-30709	DQ876698	PI	NA	M46L, I54V	L33F, N83D	L10V, I13V, K14R, E35D, M36IL, N37ND, R41K, R57K, H69Q, L89M	A
	48-1202	1202-30702	DQ877746	PI	NA	I54V, V82A, L90M	L33F, N83D	I13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93L	A
	48-4186	4186-30408	DQ878420	PI	NA	I54V, V82A	L24I, L33I, Q58E, N83D	L10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93L	A
	48-4217	4217-30915	DQ878451	PI	NA	M46L, I54V, I84V, L90M	L33F, K43T, N88G	L10I, I13V, K14R, K20R, E21Q, E35D, M36I, N37D, Q61N, I62V, L63Q, H69K, A71L, T74S, Q92R, I93M	A
	48-5010	5010-30820	DQ878543	PI	NA	M46MIL, I54V, V82A	Q58E	L10I, I13V, K20KR, E35D, M36I, N37ND, R41K, I62V, L63P, A71T	A
	48-5021	5021-30606	DQ878555	PI	NA	I54V, V82F, I84IV, L90M	L33F, F53L	L10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89M	A
	48-5031	5031-30421	DQ878557	PI	NA	M46I, I54V, V82A	G73S	I13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89T	A
	48-5032	5032-30421	DQ878558	PI	NA	I54V, L90M	L10F, L33I, L89V	I13V, E35D, M36I, R41K, R57K, I62IV, L63LP, H69K	A
Tee (2006)	MYKL1855	04MYKL1855	AY960955	LPV		I54V, V82F	L33I, L89V	L10I, I13V, Q18H, A22V, E35D, M36I, N37D, H69K, A71V, I93M	A
Barber (2012)	67784	67784	JQ361691	LPV		I54V		I13V, G17D, K20R, E35D, M36I, R41K, R57K, D60E, I62V, L63I, H69K, L89M	A
Jones (2012)	159797	159797	JN669961	PI	NA	M46I, I54V, L76V, V82A	L33LF	L10I, I13V, I15IV, G16E, K20M, E35D, M36I, R41K, K55R, R57K, Q61N, A71T, I72R, L89I	A
	178278	178278	JN670478	PI	NA	I54V, V82VA, L90LM	L10F, F53L	I13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, H69K, K70R, T74A, L89M, T91V	A
	182090	182090	JN670599	PI	NA	M46I, I54V, L76V	L89V	K20P, E35N, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92K	A
	199883	199883	JN671186	PI	NA	M46I, I54V, V82A, L90M	N88D	L10I, I13V, I15V, L19I, K20I, E35D, M36I, N37K, R41K, K45R, K55R, R57K, Q61N, L63P, C67F, A71T, I72E	A

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