<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation I54V
Rx >= 1 PI
IncludeMixtures No
References 13
Patients 29
Isolates 29
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M29M29AY010392IDV M46I, I54V, V82F L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89IA
Ariyoshi (2003)JPN41JPN41A IDV, SQV, NFV125G48ST, I54V, V82F, L90M L10I, I13V, G16E, K20I, E35D, M36I, P39Q, R41K, K45V, I62V, L63P, H69K, L89MA
Gomez-Carrillo (2004)103396103396AY365678PINAI54V I13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, I66F, G68E, H69R, L89M, T91VA
Montes (2004)MB_patMAK01_MAK719AJ577939SQV, RTV, NFV, LPV203M46I, I54V, I84VF53LL10V, I13V, K14R, G17E, K20I, E35D, M36I, R41K, H69K, T74A, L89MA
Non-B Workgroup (2005)TK2012TK2012 RTV, IDV, SQV186I54V, L90M L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89IA
 TK4003TK4003a NFV215I54VL33I, N83DL10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89IA
Weber (2005)89M262689M2626AY677414SQV, NFV, RTV261I54V, L90MF53L, L89VL10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74SA
Baxter (2006)12-20242024-30709DQ876698PINAM46L, I54VL33F, N83DL10V, I13V, K14R, E35D, M36IL, N37ND, R41K, R57K, H69Q, L89MA
 48-12021202-30702DQ877746PINAI54V, V82A, L90ML33F, N83DI13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93LA
 48-14321432-30818DQ877822PINAM46I, I54V, L76V, V82TL24IL10I, I13A, K20I, E35D, M36I, R41K, Q61H, L63P, H69K, T74S, L89IA
 48-41864186-30408DQ878420PINAI54V, V82AL24I, L33I, Q58E, N83DL10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93LA
 48-50215021-30606DQ878555PINAI54V, V82F, I84IV, L90ML33F, F53LL10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89MA
 48-50315031-30421DQ878557PINAM46I, I54V, V82AG73SI13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89TA
 48-50325032-30421DQ878558PINAI54V, L90ML10F, L33I, L89VI13V, E35D, M36I, R41K, R57K, I62IV, L63LP, H69KA
 48-50735073-30807DQ878583PINAI54V, V82A, L90ML33F, T74TPT4TS, I13V, K20R, E35D, M36I, N37D, R41K, F53I, I62IV, I66IF, H69R, L89IA
 48-50775077-30903DQ878587PINAM46L, I54V, V82AL24I, L33F, F53L, T74PL10I, I13V, L19I, K20R, E35D, M36I, N37D, Q61R, L63P, H69K, L89MA
Jones (2012)178278178278JN670478PINAI54V, V82VA, L90LML10F, F53LI13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, H69K, K70R, T74A, L89M, T91VA
Kouri (2012)CU544-09CU544-09JQ585255PINAM46I, I47V, I54V, I84V, L90ML10F, V11VI, L33I, Q58E, G73S, T74P, N88G, L89VI13AV, K14R, K20IT, E35N, M36I, N37D, R41K, I62V, L63V, H69K, K70RA
 CU1908-09CU1908-09JQ585320PINAM46I, I54V, V82F, L90ML33F, T74PK20I, E35N, M36I, R41K, K43R, F53Y, R57K, I62V, L63P, H69K, I85V, R87RK, L89MA
Acharya (2014)DGP185DGP185KJ185355RTV, ATV M46I, I54V, V82A, N88SL24I, L33F, Q58EL5I, L10V, I13V, I15V, E35D, M36I, N37E, R41K, R57K, D60E, H69K, A71V, L89MA
Nerrienet (2014)R0712188R0712188JN675747LPV M46I, G48V, I54V, L76V, V82TL89VL10R, I13A, K14R, K20I, E35D, M36I, N37D, R41K, K55N, D60E, L63P, H69K, K70R, A71V, T91A, Q92KA
 U0223070U0223070JN675763LPV I54V, V82A, L90ML10F, K43KT, L89VI13V, G16E, K20I, E35D, M36I, N37D, R41K, Q61H, L63R, H69K, A71T, T91SA
Sutherland (2015)66_POSTKT351840LPV I54V I13V, E35D, M36I, R41K, R57K, H69K, L89MA
 88_POSTKT351844LPV I54V I13V, E35D, M36I, R41K, R57K, H69K, L89MA
Ndahimana Jd Riedel (2016)21412141KT982484LPV M46I, I54V, L76V, I84V L10I, I13A, K14R, I15V, K20I, E35N, M36I, R41K, K45R, K55R, R57K, I66F, H69K, L89I, I93VA
 21402140KT982495LPV M46I, I54V, L76V, V82A L10V, I13V, G16E, K20R, E35D, M36I, R41KT, R57K, L63R, H69K, L89I, T91SA
 21332133KT982485LPV M46I, I54V, V82A, I84VL10FI13V, G16E, K20R, E35D, M36I, N37E, R41K, K45I, R57K, Q61N, L63H, H69K, K70R, I72IT, L89MA
 20292029KT982523LPV I54V, V82VAL33F, T74PL10I, I13V, E35D, M36I, R41K, R57K, L63T, H69K, V77I, L89MA
 21652165KT982498LPV M46I, I54V, V82AL10F, L33FI13V, E35D, M36I, N37D, P39Q, R41K, K45I, R57K, D60NS, Q61E, L63P, H69Q, L89I, T91SA