<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation I54V
Rx >= 1 PI
IncludeMixtures No
References 12
Patients 37
Isolates 37
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M29M29AY010392IDV M46I, I54V, V82F L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89IA
Gomez-Carrillo (2004)103396103396AY365678PINAI54V I13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, I66F, G68E, H69R, L89M, T91VA
Non-B Workgroup (2005)PL972860099AY901076IDV, RTV, ATV I54V, V82AL33I, F53L, N83DL10Y, I13V, G16E, K20R, A22AV, E35DN, M36I, N37ND, R41RK, L63T, H69K, T74S, L89M, T91AA
 TK2012TK2012 RTV, IDV, SQV186I54V, L90M L10V, I13V, K14R, I15V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, T74S, L89IA
 TK4003TK4003a NFV215I54VL33I, N83DL10V, I13V, K14R, G16E, A22V, E35D, M36I, R41K, K45R, L63T, H69R, K70R, L89IA
Weber (2005)M41971M41971AY677401IDV, NFV, LPV181I54V, V82AL10F, L33IT4TS, I13V, G16E, L19LI, K20R, E35D, M36I, N37D, R41K, K45V, K55T, R57K, L63H, H69K, K70R, L89M, T91TSA
 89M262689M2626AY677414SQV, NFV, RTV261I54V, L90MF53L, L89VL10I, I13V, K14R, K20I, E35D, M36I, N37E, R41K, R57K, H69K, A71V, T74SA
Baxter (2006)12-20242024-30709DQ876698PINAM46L, I54VL33F, N83DL10V, I13V, K14R, E35D, M36IL, N37ND, R41K, R57K, H69Q, L89MA
 48-12021202-30702DQ877746PINAI54V, V82A, L90ML33F, N83DI13V, G16E, K20R, E35D, M36I, N37D, R41K, R57RK, L63N, H69K, K70R, L89I, T91V, I93LA
 48-41864186-30408DQ878420PINAI54V, V82AL24I, L33I, Q58E, N83DL10I, I13V, G16E, K20R, A22V, E35D, M36I, N37D, R41K, L63T, H69K, I72V, T74A, L89M, T91V, I93LA
 48-42174217-30915DQ878451PINAM46L, I54V, I84V, L90ML33F, K43T, N88GL10I, I13V, K14R, K20R, E21Q, E35D, M36I, N37D, Q61N, I62V, L63Q, H69K, A71L, T74S, Q92R, I93MA
 48-50105010-30820DQ878543PINAM46MIL, I54V, V82AQ58EL10I, I13V, K20KR, E35D, M36I, N37ND, R41K, I62V, L63P, A71TA
 48-50215021-30606DQ878555PINAI54V, V82F, I84IV, L90ML33F, F53LL10I, V11L, I13V, I15V, G16E, L19P, K20I, E35N, M36I, K45V, L63T, H69K, L89MA
 48-50315031-30421DQ878557PINAM46I, I54V, V82AG73SI13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89TA
 48-50325032-30421DQ878558PINAI54V, L90ML10F, L33I, L89VI13V, E35D, M36I, R41K, R57K, I62IV, L63LP, H69KA
Tee (2006)MYKL185504MYKL1855AY960955LPV I54V, V82FL33I, L89VL10I, I13V, Q18H, A22V, E35D, M36I, N37D, H69K, A71V, I93MA
Barber (2012)6778467784JQ361691LPV I54V I13V, G17D, K20R, E35D, M36I, R41K, R57K, D60E, I62V, L63I, H69K, L89MA
Jones (2012)159797159797JN669961PINAM46I, I54V, L76V, V82AL33LFL10I, I13V, I15IV, G16E, K20M, E35D, M36I, R41K, K55R, R57K, Q61N, A71T, I72R, L89IA
 178278178278JN670478PINAI54V, V82VA, L90LML10F, F53LI13V, K20I, E35D, M36I, N37D, R41K, I62V, L63V, H69K, K70R, T74A, L89M, T91VA
 182090182090JN670599PINAM46I, I54V, L76VL89VK20P, E35N, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92KA
 199883199883JN671186PINAM46I, I54V, V82A, L90MN88DL10I, I13V, I15V, L19I, K20I, E35D, M36I, N37K, R41K, K45R, K55R, R57K, Q61N, L63P, C67F, A71T, I72EA
Kouri (2012)CU2041-09CU2041-09JQ585335PINAM46I, I54VL33I, G73SI13V, K14R, K20I, E35D, M36I, H69K, A71V, T74S, V75I, L89TA
 CU1315-09CU1315-09JQ585290PINAI54V, L90MF53L, L89VI13V, K14R, K20I, E35D, M36I, N37D, R41K, K45R, L63P, C67CY, H69K, A71IA
 CU727-09CU727-09JQ585262PINAG48V, I54V, V82AF53LL10I, I13V, I15V, K20I, E35D, M36I, R41K, I64M, H69K, T74S, L89MA
 CU544-09CU544-09JQ585255PINAM46I, I47V, I54V, I84V, L90ML10F, V11VI, L33I, Q58E, G73S, T74P, N88G, L89VI13AV, K14R, K20IT, E35N, M36I, N37D, R41K, I62V, L63V, H69K, K70RA
 CU376-10CU376-10JQ585390PINAG48V, I54V, V82A L10V, T12I, I13V, K20I, E35D, M36I, N37DE, R41K, H69K, T74S, L89IA
 CU1908-09CU1908-09JQ585320PINAM46I, I54V, V82F, L90ML33F, T74PK20I, E35N, M36I, R41K, K43R, F53Y, R57K, I62V, L63P, H69K, I85V, R87RK, L89MA
 CU2007-09CU2007-09JQ585330PINAM46I, I54V, V82A, I84VL24I, L33FL10I, T12S, G16A, L19I, K20V, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74S, L89M, I93LA
 CU1737-09CU1737-09JQ585309PINAM46MI, I54V, L76V, V82AL10F, L24I, L33FI13V, N37S, R41K, Q61QH, L63P, H69K, A71V, L89M, I93LA
 CU1124-09CU1124-09JQ585275PINAM46MI, I54V, L76V, V82AL10F, L24I, L33FI13V, N37S, R41K, L63P, H69K, A71V, L89M, I93LA
Rawizza (2013)LM3929LM3929KF241482LPV M46I, I47V, I54V, V82AF53L, Q58EL10I, I13V, K14R, I15V, K20I, L33L_L, E35G, M36I, R41K, K55R, L63T, I64M, L89MA
Grossman (2014)2727KF135039LPV119G48M, I54V, V82AL24I, L33LF, F53FLL10I, K20R, E35D, M36I, R41K, R57K, D60E, Q61D, I62V, L63P, V77VIA
Steegen (2014)10ZAKS05810ZAKS058KJ176340LPV M46I, I54V, V82A R41K, L63P, H69K, A71AV, I93LA
 09ZAKS00309ZAKS003KJ176287LPV M46I, I54V, L76V, V82AQ58QER41K, D60E, I62V, L63P, H69K, L89IA
 12ZAKS19512ZAKS195KJ176476LPV M46I, I54V, L76V, V82A Q61QH, I62V, L63V, H69K, T74S, L89M, I93LA
 10ZAKS05210ZAKS052KJ176334LPV M46I, I54V, V82A R41K, L63P, H69K, A71AV, L89LM, I93LA
 09ZAKS00109ZAKS001KJ176285LPV M46I, I54V, L76V, V82A R41K, D60E, Q61E, L63P, H69K, L89M, I93LA