<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation M46L
Rx >= 1 PI
IncludeMixtures No
References 6
Patients 12
Isolates 12
 
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Gibb (2002)DMG106106_w41 NFV41M46LN83DI13V, G16A, K20R, A22V, E35D, M36I, R41K, R57K, I64IV, H69K, L89MA
Maguire (2002)SW32381SW32381AY900671APV48M46L, I54L L10I, I13V, K20R, M36I, N37D, R41K, L63V, H69KA
Weber (2005)F73291F73291AY677477NFV195M46LL33I, N83DL10V, I13V, A22V, E35D, M36I, R41K, I62V, L63PS, H69K, T74S, L89I, I93LA
Baxter (2006)12-20242024-30709DQ876698PINAM46L, I54VL33F, N83DL10V, I13V, K14R, E35D, M36IL, N37ND, R41K, R57K, H69Q, L89MA
 48-42174217-30915DQ878451PINAM46L, I54V, I84V, L90ML33F, K43T, N88GL10I, I13V, K14R, K20R, E21Q, E35D, M36I, N37D, Q61N, I62V, L63Q, H69K, A71L, T74S, Q92R, I93MA
 48-80538053-30818DQ879078PINAM46L, G48V, I54S, V82AL33I, F53LL10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89IA
Kolomeets (2014)175175_272KJ870393PINAM46LL10FI13V, M36I, R41K, H69K, T74S, V77I, L89MA
Diaz (2015)RenG16869RenG16869KT747897PINAM46L, I54V, V82A, L90ML33IL10V, T12K, I13V, K20R, E35D, M36I, R41K, F53I, K55N, R57K, D60E, Q61N, I62V, L63S, A71T, L89I, Q92KA
 RenG15062RenG15062KT746090PINAM46L, I54V, I84V, L90MT74PL10I, V11L, I13V, I15V, L19LP, K20V, E35N, M36I, N37D, K55R, I62V, L63P, I64V, K70T, A71I, I72V, T91S, I93LA
 RenG14313RenG14313KT745341PINAM46L, I54V, V82AL10F, L33F, T74PI13V, K20I, E35D, M36I, R41K, K55R, R57K, Q61N, E65D, L89MA
 RenG12430RenG12430KT743458PINAD30N, M46L, I50L, V82AN88DL10V, T12A, I13V, I15S, G16R, K20R, E21Q, E35D, M36I, N37T, R41K, K45R, R57K, Q61N, I62V, L63AD, A71V, I72IV, T74TS, I85IV, Q92QRA
 RenG12114RenG12114KT743142PINAM46L, I54V, V82A, L90ML33I, Q58E, N83DL10IV, I13V, K14R, K20R, E35D, M36I, N37X, R41K, K55R, R57K, D60E, I62V, L63P, A71T, L89I, T91SA