<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation M46I
Rx >= 1 PI
IncludeMixtures No
References 15
Patients 35
Isolates 36
Show mutation frequency as:
Exclude mutations:

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M29M29AY010392IDV M46I, I54V, V82F L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89IA
 NY_M35M35AY010399NFV M46I, L90M L10I, I13V, K14R, G16E, K20I, E35DN, M36I, I62IV, L63S, C67D, H69R, I72T, L89M, I93IMA
Papa (2002)16GR16AF385360IDV M46I, N88SK43T, L89VI13V, K20I, E35DG, M36I, N37D, R41K, I62IV, H69K, A71TA
Grossman (2004)IL351IL351AY529589NFV226M46IQ58QEI13V, K14KR, K20KR, E35ED, M36I, N37ND, R41K, H69K, L89I, I93LA
Montes (2004)MB_patSAN01_SANC718AJ577992SQV, IDV, RTV143M46I, I84V, L90MG73S, L89VL10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69KA
Non-B Workgroup (2005)UK2149UK2149AY900859Unknown, LPVNAM46I, L76V, I84VL33I, N83DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89IA
 TK4007TK4007 NFV178M46I I13V, E35D, M36I, R41K, R57K, L63P, H69K, A71AV, L89TA
 PL3403155128 IDV, NFV207M46I, I84VL89VL10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71VA
Baxter (2006)12-21202120-30715DQ876783PINAM46I, I47V, L90ML10F, L33I, F53L, G73GS, N88G, L89VI13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71IA
  2120-40510DQ876754PI, RTV, TPV>43M46I, I47V, L90ML10F, L33I, F53L, G73S, N88G, L89VI13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71IA
 48-12041204-30709DQ877748PINAM46I, G48Q, I54T, V82FL33F, Q58E, N83DL10V, I13V, G16E, E35D, M36L, P39S, R57K, I62V, L63V, H69K, T74A, L89MA
 48-40184018-30227DQ878252PINAM46IL10F, V11I, L24I, L33F, Q58E, T74PT12TA, I13V, E35D, M36IV, N37D, I62V, L63T, H69K, K70R, I85V, L89MA
 48-41534153-30326DQ878387PINAM46I, I54L, L76V, I84VL10FI13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TSA
 48-50315031-30421DQ878557PINAM46I, I54V, V82AG73SI13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89TA
Koyalta (2009)17TCHAD-17FJ688177IDV26M46I, I84V L10I, I13V, K14R, I15V, K20I, M36I, R41K, R57K, L63P, I66F, H69N, I72V, L89IA
Charpentier (2011)CR-50CR-50FJ688256PINAM46IL10FK20I, E35D, M36I, N37D, R41K, I62IV, L63T, H69K, T74A, V77VI, I85IV, L89M, I93LA
 CR-13CR-13FJ688219PINAM46IL10F, L89VI13V, K20I, M36I, R41K, L63LP, H69K, I93MA
Barber (2012)5085750857JQ361664LPV M46I, L76V, I84V L10I, I13V, G16E, M36I, R41K, L63T, H69K, L89MA
 4882648826JQ361679LPV V32I, M46I, I47AL10F, L33I, L89VI13V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, K70R, T74SA
Jones (2012)159797159797JN669961PINAM46I, I54V, L76V, V82AL33LFL10I, I13V, I15IV, G16E, K20M, E35D, M36I, R41K, K55R, R57K, Q61N, A71T, I72R, L89IA
 182090182090JN670599PINAM46I, I54V, L76VL89VK20P, E35N, M36I, N37D, R41K, R57K, Q61N, I62V, L63P, A71T, T74S, V82I, Q92KA
 184144184144JN670673PINAM46I, I50IL, I54AV, V82AL24I, L33F, Q58EL10I, T12N, I13V, G16GE, K20I, E35N, M36I, N37E, R41K, R57K, D60E, Q61N, L63T, I72T, L89MA
 199883199883JN671186PINAM46I, I54V, V82A, L90MN88DL10I, I13V, I15V, L19I, K20I, E35D, M36I, N37K, R41K, K45R, K55R, R57K, Q61N, L63P, C67F, A71T, I72EA
Kouri (2012)CU2041-09CU2041-09JQ585335PINAM46I, I54VL33I, G73SI13V, K14R, K20I, E35D, M36I, H69K, A71V, T74S, V75I, L89TA
 CU544-09CU544-09JQ585255PINAM46I, I47V, I54V, I84V, L90ML10F, V11VI, L33I, Q58E, G73S, T74P, N88G, L89VI13AV, K14R, K20IT, E35N, M36I, N37D, R41K, I62V, L63V, H69K, K70RA
 CU737-10CU737-10JQ585413PINAV32I, M46I, I47V, L90ML33F, F53L, L89VR8G, I13V, K20T, E35D, M36I, R41K, H69K, G73D, V82IA
 CU1908-09CU1908-09JQ585320PINAM46I, I54V, V82F, L90ML33F, T74PK20I, E35N, M36I, R41K, K43R, F53Y, R57K, I62V, L63P, H69K, I85V, R87RK, L89MA
 CU2007-09CU2007-09JQ585330PINAM46I, I54V, V82A, I84VL24I, L33FL10I, T12S, G16A, L19I, K20V, E35D, M36I, N37S, R41K, L63P, H69K, A71AV, T74S, L89M, I93LA
Avidor (2013)196196 APV M46I, I84VL10FI, L33FI13V, K20R, L24LV, E35D, M36I, N37D, R41K, K45R, R57K, I62IV, H69K, L89M, I93VA
Rawizza (2013)LM3929LM3929KF241482LPV M46I, I47V, I54V, V82AF53L, Q58EL10I, I13V, K14R, I15V, K20I, L33L_L, E35G, M36I, R41K, K55R, L63T, I64M, L89MA
Thiam (2013)2841-HALD2841-HALDJN673708LPV M46I, L76V, I84VV11I, L89VL10I, I13V, L19P, K20I, E35D, M36I, R41K, I62V, H69K, K70R, A71V, I72IR, P79AS, T91TS, Q92QKA
Steegen (2014)10ZAKS05810ZAKS058KJ176340LPV M46I, I54V, V82A R41K, L63P, H69K, A71AV, I93LA
 09ZAKS00309ZAKS003KJ176287LPV M46I, I54V, L76V, V82AQ58QER41K, D60E, I62V, L63P, H69K, L89IA
 12ZAKS19512ZAKS195KJ176476LPV M46I, I54V, L76V, V82A Q61QH, I62V, L63V, H69K, T74S, L89M, I93LA
 10ZAKS05210ZAKS052KJ176334LPV M46I, I54V, V82A R41K, L63P, H69K, A71AV, L89LM, I93LA
 09ZAKS00109ZAKS001KJ176285LPV M46I, I54V, L76V, V82A R41K, D60E, Q61E, L63P, H69K, L89M, I93LA