<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation M46I
Rx >= 1 PI
IncludeMixtures No
References 19
Patients 43
Isolates 47
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Yahi (2001)NY_M29M29AY010392IDV M46I, I54V, V82F L10I, I13V, I15V, K20KI, E35D, M36I, R41K, D60E, I62IV, H69Q, L89IA
Papa (2002)16GR16AF385360IDV M46I, N88SK43T, L89VI13V, K20I, E35DG, M36I, N37D, R41K, I62IV, H69K, A71TA
Grossman (2004)IL351IL351AY529589NFV226M46IQ58QEI13V, K14KR, K20KR, E35ED, M36I, N37ND, R41K, H69K, L89I, I93LA
Montes (2004)MB_patSAN01_SANC718AJ577992SQV, IDV, RTV143M46I, I84V, L90MG73S, L89VL10V, I13V, G16A, K20R, E35D, M36I, N37E, R41K, D60E, I62V, L63P, H69KA
 MB_patMAK01_MAK719AJ577939SQV, RTV, NFV, LPV203M46I, I54V, I84VF53LL10V, I13V, K14R, G17E, K20I, E35D, M36I, R41K, H69K, T74A, L89MA
  02_MAK737AJ577940SQV, RTV, NFV, LPV225M46I, I47V, I54V, I84VF53LL10I, I13V, K14R, G17E, K20I, E35D, M36I, N37E, R41K, H69K, T74A, L89MA
Chantratita (2005)G563G563DQ130136PINAD30N, M46IN88DW6R, L10V, K20R, E35D, M36I, R41K, L63P, H69K, V77I, I93LA
 NP294NP294DQ130374PINAM46II50NL10N, I13V, G16E, G17E, E35D, M36I, R41K, K43R, I62V, L63S, H69K, L89MA
Non-B Workgroup (2005)UK2149UK2149AY900859Unknown, LPVNAM46I, L76V, I84VL33I, N83DL10I, I13V, A22V, E35D, M36I, N37D, R41K, K45R, R57K, L63P, A71V, L89IA
 TK1014TK1014 RTV, SQV, NFV, IDV246M46I, I84IVL24LIL10LV, I13V, K20I, E35D, M36I, R41K, L63P, H69K, T74S, T80TA, V82X, L89IMA
 TK4007TK4007 NFV178M46I I13V, E35D, M36I, R41K, R57K, L63P, H69K, A71AV, L89TA
 PL3403155128 IDV, NFV207M46I, I84VL89VL10I, T12S, I13V, L19V, K20I, E35D, N37D, L63P, I66F, H69K, K70R, A71VA
Baxter (2006)12-21202120-30715DQ876783PINAM46I, I47V, L90ML10F, L33I, F53L, G73GS, N88G, L89VI13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71IA
  2120-40510DQ876754PI, RTV, TPV>43M46I, I47V, L90ML10F, L33I, F53L, G73S, N88G, L89VI13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71IA
 48-12041204-30709DQ877748PINAM46I, G48Q, I54T, V82FL33F, Q58E, N83DL10V, I13V, G16E, E35D, M36L, P39S, R57K, I62V, L63V, H69K, T74A, L89MA
 48-14321432-30818DQ877822PINAM46I, I54V, L76V, V82TL24IL10I, I13A, K20I, E35D, M36I, R41K, Q61H, L63P, H69K, T74S, L89IA
 48-32643264-30703DQ878168PINAM46I, I54V, I84V, L90ML10F, L89VI13V, K14KR, G16E, K20L, M36I, D60E, Q61H, L63R, I66V, H69K, K70R, A71T, P79A, I93L, C95FA
  3264-40322DQ878169PI, RTV, TPV>38M46I, I54V, I84V, L90ML10F, L89VI13V, G16E, K20L, L23M, M36I, D60E, Q61H, L63R, I66V, H69K, K70R, A71T, P79A, I93L, C95VA
 48-32933293-30722DQ878198PINAM46I, I54V, L76V, V82A, L90MV11IL10I, T12E, I13V, I15V, K20I, E35N, M36I, N37D, R41K, I62V, L63P, H69K, K70KR, A71V, T74S, L89I, T91SA
 48-33333333-30929DQ878227PINAM46I, I47V, I54V, I84VL33F, G73SL10V, I13V, I15V, K20T, E35D, M36I, P39S, R41K, Q61D, I62V, L63P, I66F, H69K, T74S, L89TA
 48-41534153-30326DQ878387PINAM46I, I54L, L76V, I84VL10FI13V, G16E, K20I, L33L_L, E35D, M36I, R57K, Q61R, L63T, H69K, L89I, T91TSA
 48-50315031-30421DQ878557PINAM46I, I54V, V82AG73SI13V, I15V, K20I, E35D, M36I, Q61H, L63D, H69K, A71V, L89TA
Charpentier (2011)CR-43CR-43FJ688249PINAM46I, V82FL10FI13V, K14R, I15V, K20I, E35D, M36I, N37D, R41K, L63T, H69K, T74TA, L89M, I93MA
 CR-13CR-13FJ688219PINAM46IL10F, L89VI13V, K20I, M36I, R41K, L63LP, H69K, I93MA
Barber (2012)5085750857JQ361664LPV M46I, L76V, I84V L10I, I13V, G16E, M36I, R41K, L63T, H69K, L89MA
 4882648826JQ361679LPV V32I, M46I, I47AL10F, L33I, L89VI13V, K20R, E35D, M36I, R41K, R57K, I62V, H69K, K70R, T74SA
Kouri (2012)CU544-09CU544-09JQ585255PINAM46I, I47V, I54V, I84V, L90ML10F, V11VI, L33I, Q58E, G73S, T74P, N88G, L89VI13AV, K14R, K20IT, E35N, M36I, N37D, R41K, I62V, L63V, H69K, K70RA
 CU1908-09CU1908-09JQ585320PINAM46I, I54V, V82F, L90ML33F, T74PK20I, E35N, M36I, R41K, K43R, F53Y, R57K, I62V, L63P, H69K, I85V, R87RK, L89MA
Avidor (2013)196196 APV M46I, I84VL10FI, L33FI13V, K20R, L24LV, E35D, M36I, N37D, R41K, K45R, R57K, I62IV, H69K, L89M, I93VA
Kim (2013)Tx22307KC120891IDV, ATV V32I, M46I, I47V, I84VL33LF, F53L, L89VL10Y, T12V, I13V, G16E, K20M, E35D, M36I, N37ND, R41K, R57K, H69K, A71I, I72RA
Rawizza (2013)LM3929LM3929KF241482LPV M46I, I47V, I54V, V82AF53L, Q58EL10I, I13V, K14R, I15V, K20I, L33L_L, E35G, M36I, R41K, K55R, L63T, I64M, L89MA
Acharya (2014)DGP185DGP185KJ185355RTV, ATV M46I, I54V, V82A, N88SL24I, L33F, Q58EL5I, L10V, I13V, I15V, E35D, M36I, N37E, R41K, R57K, D60E, H69K, A71V, L89MA
Kolomeets (2014)1717_275KJ870396LPV M46I, I54IV E35D, M36I, R41K, L63I, H69K, V77I, L89M, I93LA
  17_134KJ870283LPV M46I E35D, M36I, R41K, L63I, H69K, V77I, L89M, I93LA
Nerrienet (2014)R0712188R0712188JN675747LPV M46I, G48V, I54V, L76V, V82TL89VL10R, I13A, K14R, K20I, E35D, M36I, N37D, R41K, K55N, D60E, L63P, H69K, K70R, A71V, T91A, Q92KA
 T0630085T0630085JN675756LPV M46I, I50V, I54V, V82AL33F, T74PL10I, I13V, G16A, M36I, R41K, L63V, H69K, K70R, L89MA
 U0407179U0407179JN675767LPV M46I, I84V, L90ML10F, L33F, F53L, Q58E, G73GS, N88G, L89VI13V, K20T, E35D, M36I, R41K, K55R, R57K, L63P, I66IF, H69K, A71VA
 R1113090R1113090JN675748LPV M46I, I47V, L76V, I84VL10FI13V, G16Q, L19V, K20I, E35D, M36I, P39S, R41K, K55R, D60E, I66F, H69K, A71AV, L89MA
 T0807129T0807129JN675757LPV M46I, I47V, L76V, V82FQ58EL10I, I13V, G16E, K20I, E35DN, M36I, N37ND, K55R, L63T, I64V, H69K, I72T, L89MA
 U0907156U0907156JN675771LPV V32I, M46I, I47V, I54M, L90ML33F, Q58E, N83DL10V, I13V, G16A, M36I, N37D, R41K, K55R, D60N, L63P, I64V, H69K, K70R, A71IV, G73GD, L89IA
Diaz (2015)RenG16380RenG16380KT747408PINAM46I, I54V, L76V, V82A L10I, I13V, I15V, G16A, L19IV, K20I, E21Q, E35D, M36I, N37E, R41K, I62V, L63P, I64V, H69K, A71T, T74TSA
 RenG10743RenG10743KT741771PINAM46I, I54IV, V82VA, L90ML23LI, F53FLL10IV, T12K, I13V, K14W, G16E, L19P, K20V, E35G, M36I, N37D, R41K, I62V, L63H, I64V, H69K, A71I, T74S, V77I, L89M, I93MA
Abdellaziz (2016)1505115051KT339029PINAV32I, M46I, V82AL10F, K43T, L89VI13V, K20M, M36I, L63P, H69K, A71VA
Ndahimana Jd Riedel (2016)21412141KT982484LPV M46I, I54V, L76V, I84V L10I, I13A, K14R, I15V, K20I, E35N, M36I, R41K, K45R, K55R, R57K, I66F, H69K, L89I, I93VA
 21402140KT982495LPV M46I, I54V, L76V, V82A L10V, I13V, G16E, K20R, E35D, M36I, R41KT, R57K, L63R, H69K, L89I, T91SA
 21332133KT982485LPV M46I, I54V, V82A, I84VL10FI13V, G16E, K20R, E35D, M36I, N37E, R41K, K45I, R57K, Q61N, L63H, H69K, K70R, I72IT, L89MA
 21652165KT982498LPV M46I, I54V, V82AL10F, L33FI13V, E35D, M36I, N37D, P39Q, R41K, K45I, R57K, D60NS, Q61E, L63P, H69Q, L89I, T91SA