<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation K43R
Rx PI-naive
IncludeMixtures No
References 38
Patients 60
Isolates 60
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Carr (1999)SE8891SE8891AF069673None   I13V, I15V, E35D, M36I, R41K, K43R, R57K, L63S, H69K, L89MA
 SE8538SE8538AF069669None   I13V, I15V, E35D, M36I, R41K, K43R, R57K, L63S, H69K, L89MA
Arroyo (2004)01TZA30601TZA306AY253318None   I13V, K14R, I15V, G16E, E35D, M36I, R41K, K43R, K45R, R57K, L63S, H69K, L89MA
Eshleman (2004)ESH_Pat73ESH635AY435317None   I13V, E35D, M36I, R41K, K43R, R57K, H69K, L89MA
Weber (2005)M92872M92872AY677420None   I13V, K20R, E35D, M36I, R41K, K43R, R57K, L63P, H69K, L89MA
Visawapoka (2006)KNH1271KNH1271AY945736None   L10V, I13V, K14R, G16E, E35D, M36I, P39S, R41K, K43R, L63T, G68E, H69K, K70R, L89M, T91VA
Liu (2007)fj53fj53EF432686None   L10I, I13V, E35D, M36I, R41K, K43R, L63P, H69K, V82I, L89M, I93V, F99LA
von Wyl (2007)1234924217EF449976None  V11VIL10I, I13V, K14KR, I15V, G16E, K20I, E35D, M36I, R41K, K43R, R57RK, L63LH, H69Q, K70KR, I72V, L89MA
Church (2008)366975Y366975YEU380734None   I13V, E35D, M36I, R41K, K43R, R57K, H69K, L89MA
Land (2008)ML752ML752EU110085None   I13V, E35D, M36I, R41K, K43R, R57K, L63S, H69K, L89MA
Nyombi (2008)TBK011TBK011EU251722None   I13V, K14R, I15V, K20R, E35D, M36I, N37D, R41K, K43R, R57K, L63P, H69K, L89MA
Avi (2009)U40U40FJ154009None   I13V, K14R, G16E, K20R, E35D, M36I, R41K, K43R, L63V, H69K, L89M, I93LA
Eshleman (2009)J30993R907-156967FJ389080None   I13V, G16E, K20R, E35D, M36I, P39S, R41K, K43R, K45R, R57K, L63S, H69K, L89MA
Steegen (2009)BV106BV106-1EU872121None   I13V, E35D, M36I, R41K, K43R, R57K, L63P, H69K, K70R, L89MA
Carr (2010)1445MV01CM.1445MVGU201516None   I13V, G16E, E35D, M36I, R41K, K43R, L63V, G68E, H69K, K70R, L89I, T91V, I93LA
Djoko (2010)618CD3355FR666618None   L10V, T12S, I15V, G16E, K20R, E35D, M36I, P39S, R41K, K43R, L63T, H69K, L89MA
 673CD3191FR666673None   I13V, G16A, E35D, M36I, N37D, R41K, K43R, R57K, L63V, H69K, I72IM, L89MA
Moussa (2010)1062-BAW1HM117934None   L10I, I13V, G16E, E35D, M36I, R41K, K43R, L63H, H69K, I72M, L89MA
Hamers (2011)CP076301738CP076301738HQ993728None   I13V, E35D, M36I, N37D, R41K, K43R, I62IV, L63LFPS, H69K, L89MA
 CP076302272CP076302272HQ993772None   I13V, K14R, I15V, K20R, E35D, M36I, N37D, R41K, K43R, R57RK, L63AT, H69K, L89MA
 CP076302286CP076302286HQ993836None   L10I, I13V, E35D, M36I, R41K, K43R, R57K, L63P, H69K, K70R, L89MA
 CP076304140CP076304140HQ993876None   L10I, I13V, G16A, M36I, R41K, K43R, R57K, L63T, H69KN, K70R, V82I, L89IA
 CP076304240CP076304240HQ993933None   L10V, K20R, E35D, M36I, N37D, R41K, K43R, R57K, L63V, E65D, H69K, L89MA
 CP076304335CP076304335HQ993968None   I13V, I15V, K20R, E35D, M36I, N37D, R41K, K43R, R57K, H69K, L89MA
 CP076300897CP076300897HQ994970None   I13V, E35D, M36I, N37D, R41K, K43R, R57K, D60E, L63P, I64L, H69K, L89MA
 CP076300808CP076300808HQ995102None   I13V, I15V, E35D, M36I, R41K, K43R, R57K, L63P, H69K, K70R, L89MA
 CP076303090CP076303090HQ995267None   L10V, I13V, E35D, M36I, R41K, K43R, R57K, L63A, H69K, L89MA
 CP076303114CP076303114HQ995290None   L10V, I13V, G16E, E35D, M36I, R41K, K43R, R57K, L63H, H69K, L89MA
Ndembi (2011)AICPS438AICPS438HQ702638None   I13V, L19I, K20R, E35D, M36I, N37D, R41K, K43R, R57K, L63P, H69K, L89MA
 AICPS165AICPS165HQ702670None   T12S, I13V, K14R, K20R, E35D, M36I, N37D, R41K, K43R, R57K, L63T, H69K, I72M, L89MA
Ndase (2012)5502122255021222KC900807None   I13V, K14R, K20R, E35D, M36I, R41K, K43R, R57K, H69K, L89MA
 5707240257072402KC900567None   I13V, K14R, E35D, M36I, N37E, R41K, K43R, R57K, L63P, H69K, V77I, L89MA
Sigaloff (2012)KELKN212KELKN212JN628486None  L33II13V, E35D, M36I, R41K, K43R, R57K, H69K, L89MA
Aghokeng (2013)HJ3169HJ3169JX983028None   I13V, E35D, M36I, N37D, R41K, K43R, R57K, L63P, H69K, I72V, L89MA
Avidor (2013)12721272KC184172None   T12TA, I13V, I15V, K20KR, E35ED, M36I, N37E, R41K, K43R, Q61E, L63V, I64M, H69K, L89M, I93LA
Frentz (2013)EHR-13208EHR-13208JX299753None   I13V, E35D, M36I, R41K, K43R, R57K, L63S, H69K, I72M, L89MA
Hassan (2013)RS09000914RS09000914HQ441659None   I13V, E35D, M36I, N37ND, R41K, K43R, G49GR, R57K, L63P, H69K, K70KR, L89MA
Kemal (2013)73487348JQ364517None   I13V, E35D, M36I, N37D, R41K, K43R, R57K, D60E, L63P, H69K, L89MA
Chung (2014)KAX_37_KA301eKAX_37_KA301eKF544242None   E35D, M36I, N37D, R41K, K43R, R57K, L63C, E65D, H69K, L89MA
Hassan (2014)RS09000800RS09_800KC568488None   I13V, K20R, E35D, M36I, N37D, R41K, K43R, R57K, L63P, H69K, L89MA
 RS11000495RS11_495KC568525None  L33II13V, G16E, E35D, M36I, R41K, K43R, R57K, H69K, L89MA
Lee (2014)MBA1444MBA1444KJ907126None   I13V, E35D, M36I, N37D, K43R, R57K, L63P, H69K, L89MA
 MBA1419MBA1419KJ907104None   I13V, E35D, M36I, N37D, K43R, R57K, L63PS, H69K, L89MA
 MBA1196MBA1196KJ906893None   L10I, I13V, K14R, E35D, M36I, R41K, K43R, R57K, L63P, H69K, K70KR, L89MA
Loubet (2014)LILX011453LILX011453KJ467941None   L10V, I13V, G16E, E35D, M36I, R41K, K43R, H69K, L89MA
Dauwe (2015)NA_09099NA_09099KT863934None  L33IL10V, I13V, G16GE, E35D, M36I, R41K, K43R, R57K, H69K, L89MA
Hora (2015)DEURF09UG015DEURF09UG015KP109492None   L10I, I13V, G16E, K20R, E35D, M36I, R41K, K43R, R57K, Q61H, L63S, H69K, K70R, L89MA
Meini (2015)109276109276KM438252None   I13V, I15L, L19KT, K20R, E35D, M36I, R41K, K43R, R57K, I62V, L63A, H69KA
 111121111121KM438254None   I13V, K14R, E35D, M36I, N37E, R41K, K43R, R57K, L63A, H69K, L89MA
 111125111125KM438258None   Q7E, L10I, I13V, K14R, E35D, M36I, R41K, K43R, R57K, L63S, H69K, I72T, L89MA
Sutherland (2015)33_PREKT351835None   I13V, K14R, I15V, E35D, M36I, N37D, R41K, K43R, R57K, H69K, L89MA
Heipertz (2016)NG010499NG010499KX389622None   L10V, I13V, G16E, K20R, E35D, M36I, R41K, K43R, L63T, H69K, L89MA
Ndahimana (2016)14451445KU922806None   L10I, I13V, G16GE, L19I, K20R, E35D, M36I, R41K, K43R, R57K, H69K, L89MA
Onsongo (2016)8181KM376192None   E35D, M36I, N37E, R41K, K43R, R57K, L63T, H69K, K70R, I72T, L89MA
 8585KM376194None   E35D, M36I, R41K, K43R, R57K, L63T, H69K, L89M, I93VA
Van Tran (2016)VI-275VI-275LC101126None   I13V, G16A, M36L, N37D, R41K, K43R, L63P, H69K, K70R, L89M, I93LA
 VI-208VI-208LC101068None  L33LFI15V, G16E, E35D, M36I, R41K, K43R, R57K, L63C, H69K, L89MA
Zeh (2016)3002620_053002620_05KU248706None   E35D, M36I, R41K, K43R, L63T, H69K, L89I, T91VA
 2005470_052005470_05KU248659None   E35D, M36I, R41K, K43R, R57RK, L63LFPS, H69K, L89MA
 3000210_053000210_05KU248665None   E35D, M36I, N37K, R41N, K43R, R57K, L63P, H69KA