<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation E35N
Rx PI-naive
IncludeMixtures No
References 48
Patients 73
Isolates 75
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Nkengasong (2000)JN_IC212JN_IC212AF216982None   I13V, K14R, K20R, E35N, M36I, R41K, I64L, H69K, L89MA
Vergne (2000)LV1LV1AJ286134None   L10I, I13V, I15V, E35N, M36I, N37D, R41K, H69Q, L89MA
Carr (2001)CM53122CM53122AY037284None   I13V, E35N, M36I, N37D, R41K, L63P, H69K, V77I, L89MA
Fonjungo (2002)CM225CM225AF406723None   I13V, E35N, M36I, N37D, R41K, H69K, L89M, I93LA
 CM133CM133AF406711None   I13V, E35N, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93LA
Tebit (2002)99CMLB2699CMLB26AF355310None   I13V, E35N, M36I, N37D, R41K, H69K, L89MA
 99CMLB499CMLB4AF355303None   I13V, E35N, M36I, N37D, R41K, H69K, L89MA
Njouom (2003)58pol58polAY204320None   I13V, K20R, E35N, M36I, N37D, R41K, K43R, H69K, L89MA
Kijak (2004)1867LE02CM.1867AY371165None   I13V, E35N, M36I, N37D, R41K, L63T, H69K, L89MA
Konings (2004)KF_Pat2900CM340AY359711None   I13V, E35N, M36I, N37D, R41K, L63P, I64M, H69K, V77I, L89MA
 KF_Pat3000CM3073AY359712None   I13V, E35N, M36I, N37D, R41K, K43R, L63P, H69K, L89MA
 KF_Pat3100CM2445AY359713None   K20R, E35N, M36I, N37D, R41K, H69K, L89MA
 KF_Pat3200CM3330AY359714None   I13V, K14R, E35N, M36I, N37D, R41K, H69K, L89MA
 KF_Pat3500CM2663AY359717None   I13V, K20R, E35N, M36I, N37D, R41K, H69K, L89MA
 KF_Pat10001CM5184AY359782None   I13V, E35N, M36I, N37D, R41K, R57K, L63S, H69K, L89MA
Servais (2004)SJ_Pat31SJKLM041AJ412961None   L10M, I13V, G16E, E35N, M36I, P39S, R41K, H69K, K70R, P81PL, L89MA
Holguin (2005)1068-0000_1068-00AY248326None   I13V, E35N, M36I, N37D, P39S, R41K, L63P, H69K, L89MA
Vazquez de Parga (2005)KS98003KS98003EU345697None   I13V, K14R, E35N, M36I, R41K, H69K, V75G, L89M, I93L, C95WA
 RU98007RU98007EU345780None   I13V, K14R, E35N, M36I, R41K, H69K, L89M, I93LA
Weber (2005)F99921F99921AY714451None   L10I, I13V, K20KR, E35N, M36I, N37D, R41K, L63P, H69K, K70R, L89MA
Jayaraman (2006)2-00-06222-00-0622 None   I13V, G17E, E35N, M36I, N37D, R41K, R57K, H69K, L89MA
Koizumi (2006)YK_04CM007YK_04CM007DQ461826None   I13V, E35N, M36I, N37D, R41K, L63P, H69K, L89MA
 YK_04CM072YK_04CM072DQ461860None   I13V, E35N, M36L, N37D, R41K, H69K, L89MA
Marechal (2006)JF_034JF_034DQ443649None   E35N, M36I, N37D, R41K, L63P, H69K, L89MA
Saad (2006)MDS_01UAPol30401UAPol304DQ055259None   E35N, M36I, N37D, R41K, H69K, L89M, I93LA
Vessiere (2006)AV_M3777NAV_M3777NDQ297262None   I13V, I15V, E35N, M36I, N37D, R41K, K45KR, H69K, L89MA
 AV_M4871NAV_M4871NDQ297203None   E35N, M36I, N37D, R41K, H69K, L89MA
Baker (2007)1354KP02-1354KPAY803460None   L10I, I13V, K20I, E35N, M36I, R41K, H69Q, L89MA
Galluzzo (2007)21870RW_21870JQ220033None   T12P, I13V, E35N, M36I, N37D, R41K, R57K, H69K, L89MA
Holguin (2007)LP581187LP581187DQ009047None   I3V, L10I, I13V, I15V, K20I, E35N, M36I, R41K, R57RK, I64M, H69K, L89MA
McNulty (2007)Cam20Cam20PLDQ869197None   E35N, M36I, N37D, R41K, L63P, H69K, L89MA
  Cam20DBSDQ869196None   E35N, M36I, N37D, R41K, L63P, H69X, L89MA
Vidal (2007)U292902BU.U2929AM260253None   I13V, K14R, G17E, K20I, E35N, M36I, R41K, L63P, H69K, K70R, V77VI, L89MA
 U180302BU.U1803AM260322None   I13V, I15V, E35N, M36I, R41K, R57K, H69K, L89MA
Derache (2008)BKO-1037BKO-1037EU330722None   L10I, I13V, K14R, I15V, K20I, E35N, M36I, R41K, H69K, L89MA
Somi (2008)BG-05-066BG-05-066JQ616944None   E35N, M36I, N37D, R41K, R57K, H69K, L89MA
Aghokeng (2009)CYN851CYN851GU191584None   T12I, I13V, E35N, M36I, N37D, R41K, K45R, H69K, L89MA
 HU_0093HU_0093GU191669None   I13V, L19I, E35N, M36I, N37D, R41K, K43R, K45KR, R57K, H69K, L89MA
Bartolo (2009)HM19101AOHM191EU068328None   L10I, I13V, Q18H, L33V, E34D, E35N, M36I, N37D, R41K, C67E, H69K, K70R, L89MA
Vercauteren (2009)pt10956629065893GQ399929None   I13IV, E35N, M36I, N37D, R41RK, R57K, Q61QE, L63P, H69K, L89MA
Balode (2010)S2280S2280GU945163None   I13V, K14R, E35N, M36I, R41K, H69K, V77I, L89MA
Hattori (2010)C06-2066321C06-2066321AB864049None   L10V, T12I, I13V, I15V, G16E, E35N, M36I, N37D, R41K, R57K, Q61E, H69K, K70R, I72V, L89MA
Soares (2010)CM04_089CM04_089GU366141None   L10V, I13V, K20I, L33V, E35N, M36I, N37D, R41K, L63P, G68E, H69R, V77I, L89MA
 CM04_095CM04_095GU366143None   I13V, G16A, E35N, M36I, N37D, R41K, R57K, D60E, H69K, L89MA
 CM02_019CM02_019GU366149None   L10V, I13V, I15V, L19I, E35N, M36I, N37D, R41K, K43R, H69K, L89MA
Aghokeng (2011)HJ227HJ227JN639447None   T12A, E35N, M36I, N37D, R41K, H69K, L89MA
 HJ1956HJ1956JN639450None   L10I, I13V, I15V, K20I, E35N, M36I, N37D, R41K, L63Q, H69Q, L89MA
 HJ1871HJ1871JN639452None   I13V, L19I, K20I, E35N, M36I, N37DE, R41K, H69K, L89MA
Deshpande (2011)Pat039in1123JF414431None   I13V, K20KR, E35N, M36I, N37D, R41K, R57K, H69K, L89MA
Fokam (2011)CIRCB-10552CIRCB-10552JQ796173None   I13V, E35N, M36I, N37D, R41K, I62IV, L63PS, H69K, K70R, L89MA
Hamers (2011)CP076301567CP076301567HQ993608None   I13V, G16GE, K20R, E35N, M36I, N37D, R41K, K45R, L63V, H69K, L89MA
 CP076302296CP076302296HQ993843None   L10I, I13V, G16E, E35N, M36I, P39T, R41K, R57K, L63V, H69K, L89MA
 CP076300878CP076300878HQ995133None   I13V, G16E, K20IM, E35N, M36I, R41K, L63S, H69K, V77VI, L89MA
 CP076302050CP076302050HQ995202None  V11VIL10LI, I13V, K14KR, G16E, K20R, E35N, M36I, R41K, I62V, L63Q, H69K, L89MA
Ndembi (2011)AICPS336AICPS336HQ702650None   I13V, K20I, E35N, M36I, R41K, H69K, V77I, L89MA
Afonso (2012)ANG78ANG78JN937090None   E35N, M36I, R41K, H69K, V77I, L89MA
Caron (2012)Gab091022Gab091022JN705005None   E35N, M36V, N37D, R41K, L63G, H69K, L89MA
Mollan (2012)MK186MK186w0 None   I13V, I15IV, E35N, M36I, R41K, R57K, H69K, L89MA
Nazziwa (2012)10338021033802JX498988None   L10V, T12P, I13V, K14R, I15V, G16E, K20I, E35N, M36I, R41K, L63T, H69K, L89M, C95GA
Reynolds (2012)J7227J7227-0JN652166None   I13V, I15IV, K20I, E35N, M36I, P39PT, R41K, H69K, V77IM, L89MA
  J7227-1JN652202None   I13V, K20I, E35N, M36I, R41K, H69K, V77I, L89MA
Sigaloff (2012)KELKN250KELKN250JN628513None   K14R, I15V, G16A, L19I, E35N, M36V, R41K, R57K, L63A, H69K, L89MA
Youngpairoj (2012)cm1657cm1657DQ166429None   T12I, I13V, G16E, K20I, E35N, M36I, N37D, R41K, L63H, H69K, I72E, L89IA
 cm1672cm1672DQ166430None   L10I, I13V, E35N, M36I, N37D, R41K, R57K, H69K, L89MA
 cm10bbcm10bbDQ166433None   L10I, I13V, E35N, M36I, N37D, R41K, L63P, H69K, L89MA
Frentz (2013)EHR-01921EHR-01921JX299577None   L10I, I13V, K14R, I15V, G16E, L19P, K20I, E35N, M36I, R41K, K45R, R57K, L63S, H69K, K70R, L89MA
 EHR-13657EHR-13657JX299764None   I13V, K14R, G17E, K20I, L33V, E35N, M36I, R41K, D60E, L63P, H69K, T74S, L89MA
 EHR-55294EHR-55294JX300460None   I13V, K14R, E35N, M36I, R41K, H69K, V77I, L89MA
Hassan (2013)RS11000273RS11000273JQ698364None   T12TP, I13V, G16E, L19I, K20R, E35N, M36I, P39S, R41K, L63X, H69K, K70R, L89MA
Inzaule (2013)105105JQ914061None   I13V, E35N, M36I, N37D, R41K, R57K, D60E, I62V, H69K, K70R, L89MA
 150150JQ914050None   I13V, K14R, L19V, L33V, E35N, M36I, N37D, R41K, K45R, R57K, C67Y, H69K, L89MA
Pircher (2013)B1109B1109JX110296None   T12S, I13V, G17E, L19I, K20I, E35N, M36I, I62V, L63P, H69K, K70N, I72V, V77I, L89MA
Rusine (2013)759H759HKC841770None   L10LM, I13V, K20I, E35N, M36I, P39Q, R41K, K45R, R57K, Y59H, Q61N, L63P, H69KQ, I72IM, V77I, L89MA
 733H733HKC841754None   I13V, K14R, G16E, K20I, E35N, M36I, R41K, I64M, H69Q, I72V, L89MA
Bartolo (2014)09AOHDP29709AOHDP297KF853851None   L10I, I13V, K14R, I15V, G17GE, Q18QR, K20I, E21D, E35N, M36I, N37E, R57K, Q61QE, L63T, H69Q, L89MA