Protease Inhibitors

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Protease Inhibitors

Subtype	A
Gene	PR
Mutation	E35N
Rx	PI-naive
IncludeMixtures	No

References	40
Patients	63
Isolates	64

Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr)	Patient	Isolate	Acc#	PIs	PIMinorDRMs	OtherMut	Subtype
Nkengasong (2000)	JN_IC212	JN_IC212	AF216982	None		I13V, K14R, K20R, E35N, M36I, R41K, I64L, H69K, L89M	A
Vergne (2000)	LV1	LV1	AJ286134	None		L10I, I13V, I15V, E35N, M36I, N37D, R41K, H69Q, L89M	A
Carr (2001)	CM53122	CM53122	AY037284	None		I13V, E35N, M36I, N37D, R41K, L63P, H69K, V77I, L89M	A
Fonjungo (2002)	CM225	CM225	AF406723	None		I13V, E35N, M36I, N37D, R41K, H69K, L89M, I93L	A
	CM133	CM133	AF406711	None		I13V, E35N, M36I, N37D, R41K, L63V, I64M, H69K, L89M, I93L	A
Tebit (2002)	99CMLB26	99CMLB26	AF355310	None		I13V, E35N, M36I, N37D, R41K, H69K, L89M	A
	99CMLB4	99CMLB4	AF355303	None		I13V, E35N, M36I, N37D, R41K, H69K, L89M	A
Njouom (2003)	58pol	58pol	AY204320	None		I13V, K20R, E35N, M36I, N37D, R41K, K43R, H69K, L89M	A
Kijak (2004)	1867LE	02CM.1867	AY371165	None		I13V, E35N, M36I, N37D, R41K, L63T, H69K, L89M	A
Konings (2004)	KF_Pat29	00CM340	AY359711	None		I13V, E35N, M36I, N37D, R41K, L63P, I64M, H69K, V77I, L89M	A
	KF_Pat30	00CM3073	AY359712	None		I13V, E35N, M36I, N37D, R41K, K43R, L63P, H69K, L89M	A
	KF_Pat31	00CM2445	AY359713	None		K20R, E35N, M36I, N37D, R41K, H69K, L89M	A
	KF_Pat32	00CM3330	AY359714	None		I13V, K14R, E35N, M36I, N37D, R41K, H69K, L89M	A
	KF_Pat35	00CM2663	AY359717	None		I13V, K20R, E35N, M36I, N37D, R41K, H69K, L89M	A
	KF_Pat100	01CM5184	AY359782	None		I13V, E35N, M36I, N37D, R41K, R57K, L63S, H69K, L89M	A
Servais (2004)	SJ_Pat31	SJKLM041	AJ412961	None		L10M, I13V, G16E, E35N, M36I, P39S, R41K, H69K, K70R, P81PL, L89M	A
Holguin (2005)	1068-00	00_1068-00	AY248326	None		I13V, E35N, M36I, N37D, P39S, R41K, L63P, H69K, L89M	A
Vazquez de Parga (2005)	KS98003	KS98003	EU345697	None		I13V, K14R, E35N, M36I, R41K, H69K, V75G, L89M, I93L, C95W	A
	RU98007	RU98007	EU345780	None		I13V, K14R, E35N, M36I, R41K, H69K, L89M, I93L	A
Weber (2005)	F99921	F99921	AY714451	None		L10I, I13V, K20KR, E35N, M36I, N37D, R41K, L63P, H69K, K70R, L89M	A
Jayaraman (2006)	2-00-0622	2-00-0622		None		I13V, G17E, E35N, M36I, N37D, R41K, R57K, H69K, L89M	A
Koizumi (2006)	YK_04CM007	YK_04CM007	DQ461826	None		I13V, E35N, M36I, N37D, R41K, L63P, H69K, L89M	A
	YK_04CM072	YK_04CM072	DQ461860	None		I13V, E35N, M36L, N37D, R41K, H69K, L89M	A
Marechal (2006)	JF_034	JF_034	DQ443649	None		E35N, M36I, N37D, R41K, L63P, H69K, L89M	A
Saad (2006)	MDS_01UAPol304	01UAPol304	DQ055259	None		E35N, M36I, N37D, R41K, H69K, L89M, I93L	A
Vessiere (2006)	AV_M3777N	AV_M3777N	DQ297262	None		I13V, I15V, E35N, M36I, N37D, R41K, K45KR, H69K, L89M	A
	AV_M4871N	AV_M4871N	DQ297203	None		E35N, M36I, N37D, R41K, H69K, L89M	A
Baker (2007)	1354KP	02-1354KP	AY803460	None		L10I, I13V, K20I, E35N, M36I, R41K, H69Q, L89M	A
Galluzzo (2007)	21870	RW_21870	JQ220033	None		T12P, I13V, E35N, M36I, N37D, R41K, R57K, H69K, L89M	A
Holguin (2007)	LP581187	LP581187	DQ009047	None		I3V, L10I, I13V, I15V, K20I, E35N, M36I, R41K, R57RK, I64M, H69K, L89M	A
McNulty (2007)	Cam20	Cam20PL	DQ869197	None		E35N, M36I, N37D, R41K, L63P, H69K, L89M	A
		Cam20DBS	DQ869196	None		E35N, M36I, N37D, R41K, L63P, H69X, L89M	A
Vidal (2007)	U2929	02BU.U2929	AM260253	None		I13V, K14R, G17E, K20I, E35N, M36I, R41K, L63P, H69K, K70R, V77VI, L89M	A
	U1803	02BU.U1803	AM260322	None		I13V, I15V, E35N, M36I, R41K, R57K, H69K, L89M	A
Derache (2008)	BKO-1037	BKO-1037	EU330722	None		L10I, I13V, K14R, I15V, K20I, E35N, M36I, R41K, H69K, L89M	A
Somi (2008)	BG-05-066	BG-05-066	JQ616944	None		E35N, M36I, N37D, R41K, R57K, H69K, L89M	A
Aghokeng (2009)	CYN851	CYN851	GU191584	None		T12I, I13V, E35N, M36I, N37D, R41K, K45R, H69K, L89M	A
	HU_0093	HU_0093	GU191669	None		I13V, L19I, E35N, M36I, N37D, R41K, K43R, K45KR, R57K, H69K, L89M	A
Bartolo (2009)	HM191	01AOHM191	EU068328	None		L10I, I13V, Q18H, L33V, E34D, E35N, M36I, N37D, R41K, C67E, H69K, K70R, L89M	A
Vercauteren (2009)	pt1095	6629065893	GQ399929	None		I13IV, E35N, M36I, N37D, R41RK, R57K, Q61QE, L63P, H69K, L89M	A
Balode (2010)	S2280	S2280	GU945163	None		I13V, K14R, E35N, M36I, R41K, H69K, V77I, L89M	A
Soares (2010)	CM04_089	CM04_089	GU366141	None		L10V, I13V, K20I, L33V, E35N, M36I, N37D, R41K, L63P, G68E, H69R, V77I, L89M	A
	CM04_095	CM04_095	GU366143	None		I13V, G16A, E35N, M36I, N37D, R41K, R57K, D60E, H69K, L89M	A
	CM02_019	CM02_019	GU366149	None		L10V, I13V, I15V, L19I, E35N, M36I, N37D, R41K, K43R, H69K, L89M	A
Aghokeng (2011)	HJ227	HJ227	JN639447	None		T12A, E35N, M36I, N37D, R41K, H69K, L89M	A
	HJ1956	HJ1956	JN639450	None		L10I, I13V, I15V, K20I, E35N, M36I, N37D, R41K, L63Q, H69Q, L89M	A
	HJ1871	HJ1871	JN639452	None		I13V, L19I, K20I, E35N, M36I, N37DE, R41K, H69K, L89M	A
Deshpande (2011)	Pat039	in1123	JF414431	None		I13V, K20KR, E35N, M36I, N37D, R41K, R57K, H69K, L89M	A
Fokam (2011)	CIRCB-10552	CIRCB-10552	JQ796173	None		I13V, E35N, M36I, N37D, R41K, I62IV, L63PS, H69K, K70R, L89M	A
Hamers (2011)	CP076301567	CP076301567	HQ993608	None		I13V, G16GE, K20R, E35N, M36I, N37D, R41K, K45R, L63V, H69K, L89M	A
	CP076302296	CP076302296	HQ993843	None		L10I, I13V, G16E, E35N, M36I, P39T, R41K, R57K, L63V, H69K, L89M	A
	CP076300878	CP076300878	HQ995133	None		I13V, G16E, K20IM, E35N, M36I, R41K, L63S, H69K, V77VI, L89M	A
	CP076302050	CP076302050	HQ995202	None	V11VI	L10LI, I13V, K14KR, G16E, K20R, E35N, M36I, R41K, I62V, L63Q, H69K, L89M	A
Ndembi (2011)	AICPS336	AICPS336	HQ702650	None		I13V, K20I, E35N, M36I, R41K, H69K, V77I, L89M	A
Caron (2012)	Gab091022	Gab091022	JN705005	None		E35N, M36V, N37D, R41K, L63G, H69K, L89M	A
Hassan (2012)	RS11000273	RS11000273	JQ698364	None		T12TP, I13V, G16E, L19I, K20R, E35N, M36I, P39S, R41K, L63X, H69K, K70R, L89M	A
Nazziwa (2012)	1033802	1033802	JX498988	None		L10V, T12P, I13V, K14R, I15V, G16E, K20I, E35N, M36I, R41K, L63T, H69K, L89M, C95G	A
Sigaloff (2012)	KELKN250	KELKN250	JN628513	None		K14R, I15V, G16A, L19I, E35N, M36V, R41K, R57K, L63A, H69K, L89M	A
Youngpairoj (2012)	cm1657	cm1657	DQ166429	None		T12I, I13V, G16E, K20I, E35N, M36I, N37D, R41K, L63H, H69K, I72E, L89I	A
	cm1672	cm1672	DQ166430	None		L10I, I13V, E35N, M36I, N37D, R41K, R57K, H69K, L89M	A
	cm10bb	cm10bb	DQ166433	None		L10I, I13V, E35N, M36I, N37D, R41K, L63P, H69K, L89M	A
Frentz (2013)	EHR-01921	EHR-01921	JX299577	None		L10I, I13V, K14R, I15V, G16E, L19P, K20I, E35N, M36I, R41K, K45R, R57K, L63S, H69K, K70R, L89M	A
	EHR-13657	EHR-13657	JX299764	None		I13V, K14R, G17E, K20I, L33V, E35N, M36I, R41K, D60E, L63P, H69K, T74S, L89M	A
	EHR-55294	EHR-55294	JX300460	None		I13V, K14R, E35N, M36I, R41K, H69K, V77I, L89M	A

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