<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Protease Inhibitors

Subtype A
Gene PR
Mutation E35N
Rx PI-naive
IncludeMixtures No
References 39
Patients 55
Isolates 56
 
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Sequences matching input query are shown below. Original reference, patient identifier, isolate name, partial treatment histories and accession number are indicated. Complete treatment histories, when available, can be accessed by clicking the isolate name. Sequences may additionally be downloaded in the fasta format, or viewed as individual or composite alignments using the options above. If the user wishes to view individual alignments of isolates for which there are multiple clones, the user can choose to view either an alignment of consensus sequences derived from the clones or an alignment of each clone as well as a consensus sequence.

Author (yr) Patient Isolate Acc# PIs WksPIMajorDRMs PIMinorDRMs OtherMutSubtype
Konings (2004)KF_Pat2900CM340AY359711None   I13V, E35N, M36I, N37D, R41K, L63P, I64M, H69K, V77I, L89MA
 KF_Pat10001CM5184AY359782None   I13V, E35N, M36I, N37D, R41K, R57K, L63S, H69K, L89MA
Servais (2004)SJ_Pat31SJKLM041AJ412961None   L10M, I13V, G16E, E35N, M36I, P39S, R41K, H69K, K70R, P81PL, L89MA
Vazquez de Parga (2005)KS98003KS98003EU345697None   I13V, K14R, E35N, M36I, R41K, H69K, V75G, L89M, I93L, C95WA
 RU98007RU98007EU345780None   I13V, K14R, E35N, M36I, R41K, H69K, L89M, I93LA
Jayaraman (2006)2-00-06222-00-0622 None   I13V, G17E, E35N, M36I, N37D, R41K, R57K, H69K, L89MA
Marechal (2006)JF_099JF_099DQ443691None   L10I, T12A, I13V, K14R, I15IV, G16E, K20I, E35N, M36I, P39S, R41K, R57K, L63S, E65D, I72V, P79PH, L89MA
Saad (2006)MDS_01UAPol30401UAPol304DQ055259None   E35N, M36I, N37D, R41K, H69K, L89M, I93LA
Baker (2007)1354KP02-1354KPAY803460None   L10I, I13V, K20I, E35N, M36I, R41K, H69Q, L89MA
Galluzzo (2007)21870RW_21870JQ220033None   T12P, I13V, E35N, M36I, N37D, R41K, R57K, H69K, L89MA
Vidal (2007)U180302BU.U1803AM260322None   I13V, I15V, E35N, M36I, R41K, R57K, H69K, L89MA
Somi (2008)BG-05-066BG-05-066JQ616944None   E35N, M36I, N37D, R41K, R57K, H69K, L89MA
Bartolo (2009)HM19101AOHM191EU068328None   L10I, I13V, Q18H, L33V, E34D, E35N, M36I, N37D, R41K, C67E, H69K, K70R, L89MA
Balode (2010)S2280S2280GU945163None   I13V, K14R, E35N, M36I, R41K, H69K, V77I, L89MA
Deshpande (2011)Pat039in1123JF414431None   I13V, K20KR, E35N, M36I, N37D, R41K, R57K, H69K, L89MA
Hamers (2011)CP076301567CP076301567HQ993608None   I13V, G16GE, K20R, E35N, M36I, N37D, R41K, K45R, L63V, H69K, L89MA
 CP076302296CP076302296HQ993843None   L10I, I13V, G16E, E35N, M36I, P39T, R41K, R57K, L63V, H69K, L89MA
 CP076300878CP076300878HQ995133None   I13V, G16E, K20IM, E35N, M36I, R41K, L63S, H69K, V77VI, L89MA
 CP076302050CP076302050HQ995202None  V11VIL10LI, I13V, K14KR, G16E, K20R, E35N, M36I, R41K, I62V, L63Q, H69K, L89MA
Ndembi (2011)AICPS336AICPS336HQ702650None   I13V, K20I, E35N, M36I, R41K, H69K, V77I, L89MA
Afonso (2012)ANG78ANG78JN937090None   E35N, M36I, R41K, H69K, V77I, L89MA
Mollan (2012)MK186MK186w0 None   I13V, I15IV, E35N, M36I, R41K, R57K, H69K, L89MA
Ndase (2012)5309137253091372KC900587None   G17D, E35N, M36I, N37D, R41K, R57K, G68GE, H69K, I72V, L89MA
 5306645253066452KC900563None   K14R, G17D, E35N, M36I, N37D, R41K, R57K, H69K, L89MA
Reynolds (2012)J7227J7227-0JN652166None   I13V, I15IV, K20I, E35N, M36I, P39PT, R41K, H69K, V77IM, L89MA
  J7227-1JN652202None   I13V, K20I, E35N, M36I, R41K, H69K, V77I, L89MA
Sigaloff (2012)KELKN250KELKN250JN628513None   K14R, I15V, G16A, L19I, E35N, M36V, R41K, R57K, L63A, H69K, L89MA
Ssemwanga (2012)RCC_TDR_828529RCC_TDR_828529JQ266054None   L10I, I13V, K14R, G16E, E35N, M36I, P39S, R41K, R57K, H69K, K70E, L89MA
Zhao (2012)LB005LB005JN864050None   L10I, I13V, G16E, E35N, M36I, N37D, L63T, H69N, L89MA
Frentz (2013)EHR-01921EHR-01921JX299577None   L10I, I13V, K14R, I15V, G16E, L19P, K20I, E35N, M36I, R41K, K45R, R57K, L63S, H69K, K70R, L89MA
 EHR-13657EHR-13657JX299764None   I13V, K14R, G17E, K20I, L33V, E35N, M36I, R41K, D60E, L63P, H69K, T74S, L89MA
 EHR-55294EHR-55294JX300460None   I13V, K14R, E35N, M36I, R41K, H69K, V77I, L89MA
Hassan (2013)RS11000273RS11000273JQ698364None   T12TP, I13V, G16E, L19I, K20R, E35N, M36I, P39S, R41K, L63X, H69K, K70R, L89MA
Inzaule (2013)105105JQ914061None   I13V, E35N, M36I, N37D, R41K, R57K, D60E, I62V, H69K, K70R, L89MA
 150150JQ914050None   I13V, K14R, L19V, L33V, E35N, M36I, N37D, R41K, K45R, R57K, C67Y, H69K, L89MA
Nzeyimana (2013)201_1807201_1807HG780724None   I13V, I15V, Q18QE, E35N, M36I, R41K, H69K, L89MA
Pircher (2013)B1109B1109JX110296None   T12S, I13V, G17E, L19I, K20I, E35N, M36I, I62V, L63P, H69K, K70N, I72V, V77I, L89MA
Rusine (2013)759H759HKC841770None   L10LM, I13V, K20I, E35N, M36I, P39Q, R41K, K45R, R57K, Y59H, Q61N, L63P, H69KQ, I72IM, V77I, L89MA
 733H733HKC841754None   I13V, K14R, G16E, K20I, E35N, M36I, R41K, I64M, H69Q, I72V, L89MA
Acharya (2014)DGP035DGP035KJ185205None   I13V, G16E, Q18H, E35N, M36I, N37D, R41K, R57K, H69KA
Aghokeng (2014)CM-3-097CM-3-097KC350341None   L10I, I13V, E35N, M36I, N37D, L63P, H69K, I72IM, L89MA
Kolomeets (2014)411411_600KJ870632None   L10M, I13V, K14R, E35N, M36I, R41K, Q61E, I62V, C67S, H69K, V77I, L89MA
Lee (2014)MBA1418MBA1418KJ907103None   I13V, K14KR, L19IM, K20I, E35N, M36I, R41K, H69K, L89MA
 MBA1473MBA1473KJ907151None   I13V, K14R, G16E, K20I, E35N, M36I, R41K, L63LI, H69K, V77VIM, L89MA
Hora (2015)DEMA111RW002DEMA111RW002KF716472None   I13V, G16E, K20R, E35N, M36I, P39T, R41K, R57K, H69K, L89MA
 DE02210CM010DE02210CM010KF716460None   L10I, I13V, G16E, E35N, M36I, N37D, L63T, H69N, L89MA
Sutherland (2015)44_PREKT351837None   I13V, K14KR, K20I, E35N, M36I, R41K, H69K, V77VI, L89MA
Billings (2016)KE851891V4KE851891V4KT022376None   I13V, K20R, E35N, M36I, N37D, R41K, K45R, R57K, H69K, V77I, L89MA
 KE795643V7KE795643V7KT022384None   I13V, K20R, E35N, M36I, N37D, R41K, K45R, R57K, H69K, V77I, L89MA
 KE888800V3KE888800V3KT022397None   T12Q, G16E, E35N, M36I, N37D, R57K, H69K, L89MA
 KE376579V4KE376579V4KT022372None   T12I, I13V, E35N, M36I, N37E, R41K, R57K, H69K, V77I, L89MA
Ndahimana (2016)823823KU922832None   L10LIM, I13V, K20I, E35N, M36I, R41K, H69K, L89MA
Otecko (2016)408206408206KX306417None   T12I, K14R, I15V, G16E, K20I, E35N, M36I, R41K, K45R, R57K, L63S, I64M, H69K, L89MA
Pandey (2016)NARI-FLS_VB11VB11KT152841None   E35N, M36I, N37D, R41K, R57K, Q61E, H69K, L89MA
Zeh (2016)3003780_053003780_05KU248718None   E35N, M36I, N37D, R41K, H69K, L89MA
 0504720_040504720_04KU248537None   E35N, M36I, N37D, R41K, K45R, R57K, L63T, L89MA